GO:0005372

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Name water transmembrane transporter activity
Categary Function
Go Slim No
Go Link GO:0005372
Unique Molecular Interactions 75
Total Molecular Interactions 118
Total Single Events 1142
Pain Genes Associated 9

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for water transmembrane transporter activity. They are ordered first by their pain relevance and then by number of times they were reported for water transmembrane transporter activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT206764 Binding of AQP4 and Nqo1 8 0.05 13.45 2.84
2 INT342165 Binding of Aqp1 and Nav1 1 0.25 0.57 1.25
3 INT52955 Binding of Slc6a3 and Pdpn 1 0.17 1.11 1.22
4 INT250253 Binding of AQP4 and SLC1A2 1 0.30 2.95 1.09
5 INT73311 Binding of Oprm1 and Pdpn 1 0.08 0.71 1.06
6 INT250248 Binding of AQP4 and SLC1A3 1 0.11 1.55 0.77
7 INT334153 Binding of AQP4 and CSF2 1 0.16 3 0.75
8 INT250247 FCGR3A Negative_regulation of AQP4 1 0.01 0.87 0.62
9 INT84603 Adrb1 Regulation of Gene_expression of Aqp2 1 0.00 0 0.56
10 INT169648 IGHG3 Regulation of AQP4 3 0.02 4.63 0.55
11 INT235975 Binding of AQP4 and IgG 2 0.04 4.11 0.53
12 INT157343 Binding of AQP4 and HLA-DPB1 1 0.30 0.89 0.43
13 INT309157 Aqp1 Positive_regulation of Bdnf 1 0.00 0.74 0.42
14 INT52954 Binding of Pdpn and Flvcr2 1 0.05 0.42 0.41
15 INT250250 Gene_expression of AQP4 Positive_regulation of Gene_expression of SLC1A2 1 0.37 1.1 0.39
16 INT250242 Binding of AQP4 and GOPC 1 0.06 0.39 0.35
17 INT84600 Binding of Avp and Aqp2 1 0.17 0 0.35
18 INT308701 Binding of AQP4 and DDX41 1 0.15 3.53 0.32
19 INT139778 Binding of AQP1 and GBE1 1 0.00 0.22 0.3
20 INT235977 Binding of AQP4 and Ighg1 1 0.03 1.31 0.3
21 INT293118 Avp Regulation of Aqp2 1 0.04 0.7 0.27
22 INT308708 DDX41 Regulation of AQP4 1 0.10 2.79 0.26
23 INT58305 AQP1 Regulation of Localization of TNF 1 0.10 0.16 0.22
24 INT58303 AQP1 Regulation of Gene_expression of IL1B 1 0.10 0.16 0.22
25 INT342163 Nkx2-1 Regulation of Gene_expression of Aqp1 1 0.06 0.51 0.2
26 INT327791 Binding of AQP4 and Alms1 1 0.03 1.1 0.17
27 INT250241 SLC1A3 Positive_regulation of AQP4 1 0.13 0.21 0.16
28 INT250246 SLC1A2 Positive_regulation of AQP4 1 0.13 0.22 0.16
29 INT85333 Aqp1 Positive_regulation of Negative_regulation of Tgfb1 1 0.25 0.67 0.15
30 INT293124 Agtr1a Regulation of Gene_expression of Aqp2 1 0.17 0.36 0.14
31 INT327829 Aqp1 Regulation of Binding of Csf2 1 0.11 1 0.14
32 INT293117 Agt Regulation of Gene_expression of Aqp2 1 0.23 0.36 0.14
33 INT308709 Positive_regulation of Binding of AQP4 and DDX41 1 0.18 1.19 0.14
34 INT344314 PDPN Positive_regulation of Phosphorylation of MAPK8 1 0.35 0.67 0.13
35 INT250244 Binding of AQP4 and Positive_regulation of SLC1A3 1 0.14 0.69 0.08
36 INT234802 Binding of AQP2 and AVPR2 2 0.15 0.84 0.07
37 INT293122 Avp Regulation of Gene_expression of Aqp2 1 0.04 0.81 0.05
38 INT344312 PDPN Positive_regulation of ITK 1 0.05 0.26 0.04
39 INT344317 PDPN Negative_regulation of VEGFA 1 0.08 0.67 0.03
40 INT344308 Positive_regulation of PDPN Negative_regulation of VEGFA 1 0.09 0.24 0.03
41 INT241775 AVP Positive_regulation of Gene_expression of AQP2 1 0.08 0.17 0
42 INT297693 Binding of Aqp2 and Fut1 1 0.03 0 0
43 INT344315 MAPK8 Positive_regulation of Negative_regulation of PDPN 1 0.35 0.56 0
44 INT308706 Binding of AQP4 and M1 1 0.06 0.86 0
45 INT308702 Binding of AQP4 and CD40LG 1 0.10 0 0
46 INT308703 Positive_regulation of Binding of AQP4 and M1 1 0.08 0.61 0
47 INT344313 PDPN Positive_regulation of VEGFA 1 0.09 0.8 0
48 INT79900 NFE2L2 Positive_regulation of Gene_expression of AQP1 1 0.03 0 0
49 INT308707 Binding of AQP4 and IGHG3 1 0.01 0.88 0
50 INT344319 MAPK8 Positive_regulation of PDPN 1 0.35 0.5 0
51 INT262498 Binding of Aqp1 and Cav1 1 0.03 0.56 0
52 INT354080 Avpr2 Positive_regulation of Localization of Aqp2 1 0.02 0.07 0
53 INT293114 Fig4 Regulation of Gene_expression of Aqp2 1 0.08 1.53 0
54 INT234803 AVP Regulation of AQP2 1 0.11 1.3 0
55 INT344307 PDPN Negative_regulation of Gene_expression of VEGFA 1 0.08 0.36 0
56 INT344318 PDPN Positive_regulation of Positive_regulation of RHOA 1 0.11 0.92 0
57 INT98626 Aqp1 Positive_regulation of Aqp4 1 0.52 0 0
58 INT234796 Binding of AQP2 and AVP 1 0.15 1.1 0
59 INT344316 VEGFA Positive_regulation of PDPN 1 0.09 0.4 0
60 INT344311 PDPN Positive_regulation of Negative_regulation of VEGFA 1 0.09 0.81 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for water transmembrane transporter activity. They are ordered first by their pain relevance and then by number of times they were reported in water transmembrane transporter activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT104567 Gene_expression of Aqp1 47 0.78 44.84 28.68
2 INT140413 Gene_expression of AQP4 113 0.78 139.25 25.53
3 INT104569 Gene_expression of Aqp2 23 0.60 16.56 12.23
4 INT250282 Negative_regulation of AQP4 32 0.54 32.96 9.07
5 INT157959 Binding of AQP4 32 0.48 43.44 7.44
6 INT327801 Positive_regulation of Gene_expression of Aqp2 6 0.44 7.67 7.24
7 INT156134 Regulation of Gene_expression of Aqp1 5 0.59 7.2 5.3
8 INT85328 Negative_regulation of Aqp1 5 0.54 6.02 4.94
9 INT52952 Binding of Pdpn 8 0.13 3.57 4.79
10 INT79902 Gene_expression of AQP1 33 0.78 24.72 4.55
11 INT85326 Positive_regulation of Aqp1 7 0.65 5.9 3.71
12 INT104570 Localization of Aqp1 8 0.77 5.83 3.51
13 INT157960 Regulation of AQP4 11 0.48 21.36 3.06
14 INT169747 Localization of AQP4 17 0.75 16.64 2.79
15 INT84599 Gene_expression of Aqp2 31 0.77 22.58 2.54
16 INT140414 Positive_regulation of AQP4 25 0.64 23.43 2.47
17 INT2611 Negative_regulation of AQP1 17 0.39 10.04 2.15
18 INT141721 Binding of Aqp1 5 0.37 1.77 2.15
19 INT203308 Regulation of Aqp1 4 0.48 2.59 2.13
20 INT250272 Positive_regulation of Gene_expression of AQP4 11 0.54 9.79 1.85
21 INT84595 Negative_regulation of Aqp2 11 0.58 4.88 1.78
22 INT23176 Gene_expression of Pdpn 6 0.75 4.06 1.65
23 INT156133 Regulation of Gene_expression of Aqp2 4 0.39 1.43 1.53
24 INT211054 Positive_regulation of AQP1 3 0.33 4.53 1.41
25 INT327824 Positive_regulation of Gene_expression of Aqp1 4 0.67 5.4 1.37
26 INT73553 Gene_expression of Aqp1 23 0.67 4.65 1.34
27 INT100328 Gene_expression of AQP2 6 0.75 2.41 1.21
28 INT79557 Localization of Aqp2 5 0.73 2 1.13
29 INT166889 Positive_regulation of Gene_expression of AQP1 10 0.70 6.43 0.99
30 INT84597 Transcription of Aqp2 3 0.55 2.11 0.98
31 INT183362 Regulation of AQP1 3 0.23 1.49 0.92
32 INT84598 Regulation of Aqp2 13 0.45 4.28 0.86
33 INT108348 Positive_regulation of Aqp2 10 0.68 4.94 0.82
34 INT251679 Negative_regulation of Gene_expression of AQP4 2 0.38 10.37 0.77
35 INT67252 Regulation of Pdpn 1 0.00 0.9 0.74
36 INT149238 Positive_regulation of Gene_expression of Aqp2 5 0.66 3.07 0.73
37 INT327798 Transcription of Aqp2 1 0.34 1.02 0.72
38 INT241788 Positive_regulation of Gene_expression of AQP2 3 0.67 1.26 0.7
39 INT112326 Binding of Aqp2 3 0.11 1.01 0.69
40 INT52951 Negative_regulation of Binding of Pdpn 1 0.16 0.63 0.66
41 INT327779 Regulation of Gene_expression of AQP4 5 0.48 4.5 0.6
42 INT84596 Negative_regulation of Gene_expression of Aqp2 3 0.58 8.49 0.6
43 INT84594 Negative_regulation of Transcription of Aqp2 1 0.43 0 0.59
44 INT100322 Localization of AQP2 5 0.80 0.56 0.56
45 INT139780 Binding of AQP1 7 0.32 4.62 0.54
46 INT19592 Localization of AQP1 4 0.81 1.09 0.44
47 INT327786 Negative_regulation of Gene_expression of AQP1 3 0.29 4.21 0.44
48 INT149235 Positive_regulation of Transcription of Aqp2 1 0.45 0.72 0.4
49 INT149244 Positive_regulation of Localization of Aqp2 1 0.49 0.72 0.4
50 INT100324 Regulation of Localization of AQP2 1 0.27 0.19 0.38
51 INT157836 Regulation of Gene_expression of Aqp2 9 0.57 8.37 0.37
52 INT203374 Positive_regulation of Regulation of Aqp1 2 0.36 0.91 0.37
53 INT100323 Regulation of Gene_expression of AQP2 1 0.45 0.18 0.36
54 INT79558 Binding of Aqp2 2 0.31 0.25 0.33
55 INT293551 Regulation of Positive_regulation of Aqp1 1 0.13 0 0.31
56 INT318437 Negative_regulation of Pdpn 1 0.47 0.87 0.25
57 INT327785 Transcription of AQP4 3 0.56 2.19 0.23
58 INT250270 Regulation of Localization of AQP4 1 0.41 0.22 0.2
59 INT104568 Negative_regulation of Localization of Aqp1 1 0.36 2.47 0.2
60 INT152681 Gene_expression of PDPN 29 0.65 23.06 0.18
61 INT327780 Negative_regulation of Negative_regulation of AQP4 1 0.33 1.12 0.18
62 INT215814 Negative_regulation of Gene_expression of Aqp1 2 0.31 0.25 0.17
63 INT250280 Positive_regulation of Negative_regulation of AQP4 1 0.37 0.58 0.17
64 INT98625 Regulation of Aqp1 1 0.27 0.1 0.17
65 INT160121 Localization of PDPN 1 0.73 1.07 0.16
66 INT250279 Positive_regulation of Localization of AQP4 1 0.46 0.69 0.13
67 INT104566 Negative_regulation of Aqp2 3 0.44 1.23 0.11
68 INT215820 Negative_regulation of Aqp1 3 0.23 0.83 0.1
69 INT159343 Positive_regulation of Localization of AQP1 1 0.11 0 0.1
70 INT111047 Negative_regulation of Gene_expression of Aqp2 3 0.34 3.56 0.09
71 INT157832 Phosphorylation of Aqp2 2 0.77 2.04 0.08
72 INT327827 Negative_regulation of Gene_expression of Aqp1 1 0.45 0.8 0.08
73 INT262510 Regulation of Gene_expression of Aqp1 1 0.33 1.18 0.07
74 INT327778 Positive_regulation of Regulation of AQP4 1 0.37 2.84 0.07
75 INT293110 Positive_regulation of Phosphorylation of Aqp2 1 0.47 1.39 0.05
76 INT344332 Positive_regulation of Gene_expression of PDPN 1 0.58 0.72 0.04
77 INT344330 Phosphorylation of PDPN 1 0.53 0.15 0.04
78 INT293105 Positive_regulation of Positive_regulation of Aqp2 1 0.47 0.72 0.03
79 INT241787 Negative_regulation of AQP2 1 0.57 1.38 0.03
80 INT280794 Localization of Aqp2 2 0.36 0.07 0
81 INT262504 Positive_regulation of Aqp1 1 0.25 0.43 0
82 INT344342 Binding of PDPN 1 0.31 0.74 0
83 INT157833 Negative_regulation of Negative_regulation of Aqp2 1 0.36 0 0
84 INT286264 Positive_regulation of Negative_regulation of AQP1 1 0.01 0.79 0
85 INT280786 Phosphorylation of Aqp2 1 0.32 0.24 0
86 INT327783 Regulation of Transcription of AQP4 1 0.35 1.03 0
87 INT262513 Negative_regulation of Binding of Aqp1 1 0.23 0.64 0
88 INT297668 Positive_regulation of Aqp2 1 0.45 0 0
89 INT108349 Regulation of AQP2 1 0.44 0 0
90 INT100325 Positive_regulation of AQP2 1 0.69 0 0
91 INT341042 Positive_regulation of Protein_catabolism of Aqp2 1 0.34 0.07 0
92 INT262514 Binding of Aqp1 1 0.20 0.64 0
93 INT344340 Negative_regulation of Gene_expression of PDPN 1 0.36 1.53 0
94 INT344339 Positive_regulation of PDPN 1 0.39 0.98 0
95 INT327788 Regulation of Regulation of AQP4 1 0.21 0.75 0
96 INT100326 Positive_regulation of Localization of AQP2 1 0.69 0 0
97 INT341039 Protein_catabolism of Aqp2 1 0.47 0.06 0
98 INT299193 Transcription of Aqp1 1 0.56 0.62 0
99 INT262511 Positive_regulation of Gene_expression of Aqp1 1 0.37 1.78 0
100 INT344335 Regulation of PDPN 1 0.38 0.41 0
101 INT344343 Transcription of PDPN 1 0.60 0.54 0
102 INT327782 Regulation of Gene_expression of AQP1 1 0.36 1.63 0
103 INT344337 Regulation of Negative_regulation of PDPN 1 0.23 0.05 0
104 INT100327 Regulation of Positive_regulation of AQP2 1 0.39 0 0
105 INT344334 Negative_regulation of PDPN 1 0.36 2.76 0
106 INT344333 Negative_regulation of Binding of PDPN 1 0.36 0.74 0
107 INT202389 Phosphorylation of Pdpn 1 0.61 0 0
108 INT262512 Localization of Aqp1 1 0.40 0.7 0
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