GO:0005496

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Name steroid binding
Categary Function
Go Slim No
Go Link GO:0005496
Unique Molecular Interactions 864
Total Molecular Interactions 1094
Total Single Events 11279
Pain Genes Associated 54

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for steroid binding. They are ordered first by their pain relevance and then by number of times they were reported for steroid binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT142177 Calca Positive_regulation of Gene_expression of Igf1 8 0.78 3.57 5.71
2 INT108810 Esr1 Positive_regulation of Binding of Oprm1 1 0.51 1.79 3.22
3 INT145826 Calca Positive_regulation of Gene_expression of Igf1 3 0.75 3.05 1.66
4 INT32937 Binding of Pgrmc1 and Dtnb 1 0.20 0 1.61
5 INT212660 Nr3c1 Regulation of KCNA1 1 0.00 1.25 1.57
6 INT100784 RYBP Positive_regulation of CYP3A4 1 0.44 0 1.54
7 INT123899 Binding of CYP3A4 and UGT2B7 1 0.52 0 1.46
8 INT29599 Binding of Cyp21a1 and Adarb1 1 0.01 0 1.38
9 INT158079 Binding of Esr1 and Gper 1 0.31 0.97 1.35
10 INT222182 Binding of ESR1 and HLA-DRB2 1 0.00 3.1 1.35
11 INT150890 Binding of Esr1 and Esr2 2 0.52 2.06 1.31
12 INT150835 Gper Positive_regulation of Localization of Prkce 1 0.15 0.62 1.18
13 INT131887 Nr3c1 Regulation of Gene_expression of Prkcg 1 0.01 0 1.17
14 INT264988 Binding of CYP2C19 and CYP3A4 1 0.18 0.72 1.09
15 INT264987 Binding of CYP2C9 and CYP3A4 1 0.19 0.71 1.08
16 INT106345 Igf1 Regulation of Localization of Acot1 1 0.06 0 1.02
17 INT12141 Igf1 Negative_regulation of Chat 1 0.32 0.63 1
18 INT278292 Binding of CRP and ESR1 6 0.09 10.92 0.96
19 INT279166 Binding of Cyp3a23/3a1 and Nr3c2 1 0.00 0.61 0.9
20 INT128859 Positive_regulation of RXRA Regulation of Gene_expression of OPRM1 1 0.05 0.26 0.9
21 INT122350 Ngf Regulation of Hsd3b1 1 0.34 0 0.87
22 INT65807 Nr3c1 Positive_regulation of Cyp3a23/3a1 1 0.14 0 0.82
23 INT108811 Esr2 Positive_regulation of Binding of Oprm1 1 0.46 0.44 0.79
24 INT108812 Esr1 Positive_regulation of Positive_regulation of Oprm1 1 0.42 0.38 0.78
25 INT258798 Binding of NR3C1 and HSP90AA1 1 0.01 1.09 0.78
26 INT100783 Binding of CYP2B6 and CYP3A4 2 0.17 2 0.77
27 INT104749 Ugt1a1 Regulation of Positive_regulation of G2e3 1 0.00 0.07 0.77
28 INT110130 NR3C1 Regulation of ADORA1 1 0.04 0.73 0.77
29 INT104748 Ugt1a1 Regulation of Positive_regulation of LOC100359830 1 0.01 0.07 0.77
30 INT137699 AR Regulation of PDYN 1 0.46 0.93 0.75
31 INT291548 Binding of Gper and Sec22b 1 0.02 0.94 0.67
32 INT38057 Binding of Crp and Esr1 2 0.04 1.21 0.65
33 INT114947 YY1 Positive_regulation of Gene_expression of RXRA 1 0.33 0.25 0.65
34 INT114951 PPARA Positive_regulation of Gene_expression of RXRA 1 0.34 0.25 0.64
35 INT231027 LOC100366054 Negative_regulation of Gene_expression of Pgr 1 0.02 0 0.62
36 INT114949 NCOA1 Positive_regulation of Gene_expression of RXRA 1 0.13 0.24 0.61
37 INT309158 Binding of Esr1 and Dlat 1 0.04 1.39 0.61
38 INT52820 Oprd1 Regulation of NR3C1 1 0.02 0.17 0.61
39 INT315334 Binding of CYP3A4 and CDIPT 3 0.04 0.85 0.59
40 INT109802 Binding of Esr2 and Oprl1 1 0.22 0.1 0.59
41 INT261828 Igf1 Regulation of Localization of Trpv2 1 0.02 1.04 0.58
42 INT156668 Gh Positive_regulation of Igf1 5 0.22 2.07 0.57
43 INT317639 Igf1 Regulation of Creb1 1 0.23 0.16 0.57
44 INT30989 Pgrmc1 Positive_regulation of Penk 1 0.00 0 0.57
45 INT341594 Binding of ESR1 and HLA-B 1 0.01 0.72 0.57
46 INT156667 Gh Positive_regulation of Gene_expression of Igf1 6 0.28 0.88 0.56
47 INT150291 Grk1 Positive_regulation of Gene_expression of Igf1 1 0.16 0.98 0.55
48 INT106347 Igf1 Regulation of Chat 1 0.44 0 0.55
49 INT60481 Binding of Ugt1a1 and UGT1A6 1 0.23 0 0.55
50 INT129869 SERPINA6 Regulation of AVP 1 0.25 2.33 0.54
51 INT310701 RPLP0 Regulation of Positive_regulation of PGR 1 0.01 0.49 0.53
52 INT185490 Atp5o Negative_regulation of Gene_expression of P2rx7 1 0.01 0.87 0.53
53 INT231034 Sec22b Positive_regulation of Gene_expression of Pgr 1 0.04 0.09 0.53
54 INT30987 Pgrmc1 Positive_regulation of Pdyn 1 0.01 0 0.52
55 INT150833 Esr1 Positive_regulation of Localization of Prkce 1 0.08 0.29 0.51
56 INT291556 Binding of ESR1 and Sec22b 2 0.00 0.86 0.5
57 INT27730 Binding of ALB and Shbg 2 0.01 0.44 0.5
58 INT130335 Binding of Mc4r and Nr3c2 1 0.06 1.87 0.5
59 INT154014 Binding of Esr1 and Gabrg1 1 0.07 0.07 0.5
60 INT55553 Avp Regulation of Serpina6 1 0.02 0 0.49
61 INT132242 NR3C1 Regulation of Gene_expression of Slc1a1 1 0.09 0.62 0.49
62 INT179237 Binding of SERPINA6 and POMC 1 0.03 1.15 0.49
63 INT352031 Binding of NR3C1 and JUND 1 0.10 2.87 0.48
64 INT108568 Calca Positive_regulation of Igf1 1 0.51 0.08 0.48
65 INT141729 NR3C1 Regulation of Positive_regulation of Cnr1 1 0.06 0.7 0.47
66 INT136141 Hsd11b1 Positive_regulation of Gene_expression of Agrp 1 0.64 0.2 0.47
67 INT185917 Binding of AR and MAPK1 1 0.07 0.5 0.47
68 INT147179 Esr1 Regulation of Gene_expression of Penk 1 0.01 0.68 0.46
69 INT123897 Binding of CYP3A4 and SLC35A2 1 0.39 0 0.45
70 INT252425 Positive_regulation of AR Positive_regulation of Gene_expression of CXCL10 1 0.00 0.9 0.44
71 INT151637 Binding of Cyp21a1 and Ear11 1 0.01 0 0.44
72 INT323840 Binding of Esr1 and Il1 1 0.04 0.9 0.42
73 INT261374 Nsdhl Regulation of Esr2 1 0.05 0.76 0.41
74 INT261370 Nsdhl Regulation of Esr1 1 0.01 0.75 0.41
75 INT346151 Binding of ADM and GPER 1 0.01 0.99 0.41
76 INT123898 CYP3A4 Regulation of UGT2B7 1 0.22 0 0.41
77 INT49716 PCA Negative_regulation of Nr3c2 1 0.02 0 0.41
78 INT264522 Binding of GPER and PTGDS 1 0.03 1.22 0.4
79 INT61660 Binding of CHAT and CYP21A2 1 0.00 0 0.4
80 INT227566 NR3C1 Positive_regulation of RS1 1 0.01 0 0.4
81 INT139047 Negative_regulation of AR Negative_regulation of Positive_regulation of CPOX 1 0.07 0.76 0.4
82 INT227568 NR3C1 Positive_regulation of HTR1A 1 0.00 0 0.4
83 INT99304 Igf1 Positive_regulation of Gh1 1 0.44 0.39 0.39
84 INT117361 Binding of Esr1 and sea 1 0.02 1.38 0.38
85 INT199974 ESR1 Negative_regulation of Gene_expression of ITGB3BP 1 0.05 0.47 0.38
86 INT197591 Esr1 Regulation of Pgr 1 0.04 0 0.38
87 INT73772 NR3C1 Regulation of Regulation of Crh 1 0.02 0.68 0.38
88 INT117359 Binding of Esr1 and Wbc1 1 0.00 1.38 0.37
89 INT265015 Pgr Positive_regulation of Sds 1 0.04 0.49 0.37
90 INT304340 FKBP5 Regulation of NR3C1 1 0.05 0.71 0.37
91 INT245328 Binding of Esr2 and Pgr 1 0.03 0.41 0.37
92 INT272951 Binding of TNF and Igf1 1 0.14 1.48 0.36
93 INT272953 Negative_regulation of Binding of TNF and Igf1 1 0.16 1.48 0.36
94 INT63278 Gpm6a Regulation of Igf1 1 0.01 0 0.36
95 INT272952 Igf1 Positive_regulation of Localization of TNF 1 0.19 1.53 0.35
96 INT252453 Binding of AR and Adora2b 1 0.05 0 0.35
97 INT291555 Binding of ESR1 and Dlat 1 0.01 0.6 0.35
98 INT277656 Igf1 Positive_regulation of Igfbp3 1 0.01 0.4 0.34
99 INT291554 Binding of ESR1 and St8sia2 1 0.01 0.49 0.33
100 INT291543 Binding of Dlat and Gper 1 0.15 0.37 0.33
101 INT75641 AR Positive_regulation of Positive_regulation of EIF2B3 1 0.02 0 0.33
102 INT95552 Binding of Dbp and Shbg 3 0.01 2.09 0.32
103 INT350214 Binding of GPER and HSPG2 1 0.00 0.12 0.32
104 INT349664 PYCARD Negative_regulation of Localization of AR 1 0.05 0 0.32
105 INT349662 Binding of PYCARD and Negative_regulation of Localization of AR 1 0.05 0 0.32
106 INT128756 Binding of Esr1 and Foxc1 1 0.01 0.43 0.32
107 INT235884 Htr3a Regulation of Nr3c1 1 0.00 0.63 0.32
108 INT336936 Binding of GSR and Nr3c2 1 0.06 2.29 0.31
109 INT194358 Binding of Ddt and Scgb1d2 1 0.01 0 0.31
110 INT333453 Binding of PPARA and RXRA 1 0.02 0 0.31
111 INT336933 Binding of Nr3c2 and Ugcg 1 0.07 2.3 0.31
112 INT65268 Igf1 Positive_regulation of Col7a1 1 0.48 0 0.3
113 INT309156 Esr1 Regulation of Gene_expression of Dlat 1 0.05 1.06 0.3
114 INT132984 CYP3A4 Positive_regulation of Gene_expression of PPP4C 1 0.44 0 0.3
115 INT136143 Positive_regulation of Binding of Agrp and Hsd11b1 1 0.43 0.56 0.3
116 INT136142 Binding of Agrp and Hsd11b1 1 0.33 0.56 0.3
117 INT222301 Binding of ERBB2 and ESR1 5 0.36 5.07 0.29
118 INT158734 Esr1 Regulation of Esrrb 1 0.00 0.28 0.29
119 INT323653 Binding of Igf1 and Igfbp1 1 0.20 1.14 0.29
120 INT158733 Esr1 Regulation of Plxna3 1 0.03 0.27 0.29
121 INT266766 Binding of PGR and GOPC 1 0.00 1.08 0.29
122 INT177476 Gnrhr Positive_regulation of Localization of Igf1 1 0.05 1.01 0.28
123 INT185092 CRP Positive_regulation of ESR1 1 0.06 2.83 0.28
124 INT291641 Binding of DST and ESRRG 1 0.16 1.8 0.28
125 INT199978 ESR1 Regulation of ITGB3BP 1 0.03 0.39 0.28
126 INT71904 Binding of ESR1 and PGR 6 0.34 3.79 0.27
127 INT323152 Binding of DBT and ESR1 2 0.02 1.29 0.27
128 INT50303 Igf1 Regulation of Localization of Gnrhr 1 0.05 0.09 0.27
129 INT49717 PCA Regulation of Nr3c2 1 0.01 0 0.27
130 INT103279 PGR Negative_regulation of Gene_expression of CCL5 1 0.32 0.31 0.27
131 INT346195 AMELX Negative_regulation of ESR1 1 0.02 0.36 0.26
132 INT103280 PGR Negative_regulation of Positive_regulation of ATF4 1 0.02 0.31 0.26
133 INT121830 Binding of Scgb1d2 and Lnp 1 0.02 0.33 0.26
134 INT245640 Nr3c2 Regulation of Positive_regulation of Hpse 1 0.08 0.66 0.26
135 INT262227 Nr1h4 Regulation of Transcription of CYP3A4 1 0.08 0.12 0.26
136 INT263587 Pdia3 Negative_regulation of Binding of Esr1 1 0.07 1.86 0.26
137 INT272997 Binding of CYP3A4 and IL33 1 0.03 0 0.25
138 INT310700 PGR Regulation of Gene_expression of RPLP0 1 0.01 0.37 0.25
139 INT223042 AR Positive_regulation of ADCY1 1 0.01 0.41 0.25
140 INT186783 Binding of ESR1 and NRIP1 1 0.31 0.79 0.25
141 INT199970 CYP19A1 Positive_regulation of Gene_expression of ESR1 1 0.06 0.72 0.25
142 INT182346 Binding of Cd3e and Esr1 1 0.06 1.26 0.25
143 INT97188 Gh Positive_regulation of Localization of Igf1 1 0.02 0.54 0.25
144 INT182349 Binding of Ms4a1 and Esr1 1 0.04 1.26 0.25
145 INT199971 IL6 Positive_regulation of ESR1 1 0.08 0.84 0.24
146 INT257776 Phosphorylation of AR Positive_regulation of Localization of TAB2 1 0.26 0.38 0.24
147 INT262229 Binding of CYP3A4 and Casr 1 0.03 0.37 0.24
148 INT185489 Atp5o Negative_regulation of P2rx7 1 0.01 0.29 0.24
149 INT108841 RXRG Positive_regulation of GDF15 1 0.41 0.58 0.24
150 INT252427 IGKV2D-29 Regulation of Gene_expression of AR 1 0.02 0 0.24
151 INT309160 Binding of Esr1 and Edc4 1 0.03 0.34 0.24
152 INT210803 Igh-Dex Regulation of Nr3c1 1 0.05 0 0.24
153 INT197590 Esr2 Positive_regulation of Negative_regulation of Pgr 1 0.16 0 0.24
154 INT139046 Negative_regulation of AR Negative_regulation of Phosphorylation of DYT10 1 0.33 0.34 0.23
155 INT159163 Binding of Esr2 and Regulation of Gper 1 0.41 0.27 0.23
156 INT139050 Negative_regulation of AR Negative_regulation of Phosphorylation of PRKCB 1 0.02 0.34 0.23
157 INT63203 INS Positive_regulation of ESR1 1 0.09 0.3 0.23
158 INT139045 Negative_regulation of AR Negative_regulation of CPOX 1 0.07 0.34 0.23
159 INT139048 Negative_regulation of AR Negative_regulation of Positive_regulation of TRAF3IP2 1 0.02 0.34 0.23
160 INT63193 POMC Positive_regulation of PGR 1 0.17 0.3 0.23
161 INT63199 INS Positive_regulation of PGR 1 0.11 0.3 0.23
162 INT261389 Nsdhl Positive_regulation of Esr2 1 0.06 1.04 0.23
163 INT139049 Negative_regulation of AR Negative_regulation of Positive_regulation of DYT10 1 0.33 0.34 0.23
164 INT179229 Binding of GSR and NR3C2 1 0.03 0.37 0.23
165 INT245590 Ghr Positive_regulation of Gene_expression of Igf1 1 0.34 0.61 0.23
166 INT63198 POMC Positive_regulation of ESR1 1 0.14 0.3 0.23
167 INT115729 Binding of CYP3A7 and CYP3A4 1 0.44 0.05 0.23
168 INT220383 Binding of Igf1 and Cotl1 1 0.03 0.37 0.22
169 INT270135 Binding of ESR1 and RALA 1 0.11 0.37 0.22
170 INT63192 PTH Positive_regulation of ESR1 1 0.20 0.29 0.22
171 INT63194 PTH Positive_regulation of PGR 1 0.25 0.29 0.22
172 INT107219 Binding of P2rx7 and Atp5o 1 0.03 0.07 0.21
173 INT173946 Igf1 Regulation of Gene_expression of IGF1 1 0.08 0.68 0.21
174 INT173944 IGF1 Regulation of Gene_expression of Igf1 1 0.08 0.68 0.21
175 INT35151 PLOD1 Regulation of PGR 1 0.09 0 0.21
176 INT35152 GH1 Regulation of PGR 1 0.08 0 0.21
177 INT35156 FSHR Regulation of PGR 1 0.18 0 0.21
178 INT286070 Igf1 Regulation of Regulation of Ins1 1 0.10 1.7 0.2
179 INT342057 Binding of gr and Esrrb 1 0.00 0 0.2
180 INT318039 CDIPT Positive_regulation of CYP3A4 1 0.06 0.06 0.2
181 INT106825 Ednra Negative_regulation of Igf1 1 0.07 0.07 0.2
182 INT286071 Igf1 Regulation of Ins1 1 0.10 1.69 0.2
183 INT250537 Ptpn6 Negative_regulation of Igf1 1 0.08 0 0.2
184 INT308645 Binding of Esr1 and Itpr3 1 0.00 0 0.2
185 INT262224 Sfn Negative_regulation of Transcription of CYP3A4 1 0.06 0.58 0.2
186 INT351086 Negative_regulation of ERBB2 Positive_regulation of Gene_expression of ESR1 1 0.10 0.75 0.19
187 INT351089 FOXO3 Positive_regulation of Gene_expression of ESR1 1 0.04 0.74 0.19
188 INT79651 PTGS2 Positive_regulation of Phosphorylation of NR3C1 1 0.07 0.1 0.19
189 INT192219 CASP3 Regulation of ESR1 1 0.03 1.19 0.19
190 INT197618 Binding of Esr1 and Ppt1 1 0.01 0 0.18
191 INT287145 Binding of PNN and Shbg 1 0.07 0.14 0.18
192 INT52306 Nr3c1 Negative_regulation of Transcription of Penk 1 0.26 0 0.18
193 INT330986 CYP2C9 Positive_regulation of Gene_expression of CYP3A4 1 0.39 0 0.18
194 INT173932 Binding of Esr1 and Il6 1 0.03 0.11 0.18
195 INT151895 Binding of CYP3A4 and GBE1 1 0.01 0.24 0.18
196 INT222300 Binding of ERBB2 and PGR 2 0.34 1.89 0.17
197 INT198382 Binding of AR and SRD5A1 2 0.06 0.84 0.17
198 INT231033 Igf1 Positive_regulation of Sec22b 1 0.06 0 0.17
199 INT175991 Binding of VEGFA and Igf1 1 0.04 0.57 0.17
200 INT201865 Binding of PGR and NCOA1 1 0.03 0 0.17

Single Events

The table below shows the top 100 pain related interactions that have been reported for steroid binding. They are ordered first by their pain relevance and then by number of times they were reported in steroid binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT5374 Gene_expression of Esr1 412 0.77 263.89 67.34
2 INT822 Gene_expression of ESR1 529 0.78 302.16 63.64
3 INT50405 Negative_regulation of CYP3A4 238 0.59 53.65 51.51
4 INT3361 Positive_regulation of Esr1 273 0.69 208.53 44.81
5 INT9082 Positive_regulation of ESR1 238 0.69 148.51 36.69
6 INT14559 Gene_expression of Igf1 254 0.78 112 34.17
7 INT8915 Gene_expression of Igf1 199 0.78 78.58 32.51
8 INT22211 Positive_regulation of CYP3A4 110 0.70 22 28.27
9 INT12129 Gene_expression of CYP3A4 107 0.78 23.11 27.6
10 INT37296 Binding of Esr1 117 0.43 62.51 27.33
11 INT5206 Gene_expression of AR 316 0.78 113.83 27.29
12 INT20462 Binding of ESR1 210 0.44 102.7 26.34
13 INT14556 Positive_regulation of Igf1 105 0.69 52.21 24.04
14 INT823 Negative_regulation of ESR1 144 0.58 63.72 22.52
15 INT2386 Gene_expression of Pgr 112 0.78 45.46 22.19
16 INT7573 Positive_regulation of Nr3c2 38 0.67 20 21.84
17 INT85952 Positive_regulation of AR 168 0.67 64.36 20.66
18 INT4067 Negative_regulation of Esr1 97 0.50 43.45 17.52
19 INT50579 Binding of CYP3A4 84 0.48 17.52 17.45
20 INT17237 Regulation of Esr1 74 0.43 49.09 17.25
21 INT92354 Localization of ESR1 77 0.75 33.04 15.51
22 INT2630 Positive_regulation of Shbg 134 0.70 65.26 15.19
23 INT73916 Gene_expression of Esr1 58 0.77 26.59 15.15
24 INT65263 Positive_regulation of Gene_expression of Igf1 61 0.69 25.69 14.49
25 INT12321 Binding of Nr3c2 19 0.46 5.44 13.46
26 INT64563 Gene_expression of UGT1A1 27 0.75 3.31 13.43
27 INT2038 Localization of Esr1 104 0.79 40.12 13.27
28 INT17539 Positive_regulation of Igf1 68 0.69 28.47 13.02
29 INT27242 Gene_expression of PGR 153 0.75 98.77 12.79
30 INT9832 Gene_expression of Shbg 96 0.75 56.71 12.19
31 INT79545 Positive_regulation of Gene_expression of ESR1 82 0.64 39.42 12.18
32 INT12315 Gene_expression of Nr3c2 37 0.75 19.28 11.97
33 INT3602 Negative_regulation of Shbg 148 0.53 69.05 11.65
34 INT79656 Positive_regulation of NR3C1 14 0.68 6.38 10.83
35 INT91774 Gene_expression of Nr3c1 27 0.78 16.14 10.7
36 INT7577 Regulation of Nr3c2 16 0.56 7.7 10.1
37 INT35366 Binding of AR 87 0.47 30.52 8.9
38 INT22798 Regulation of Shbg 64 0.60 26.71 8.76
39 INT26751 Regulation of Nr3c1 13 0.61 6.58 8.65
40 INT10065 Positive_regulation of Serpina6 12 0.70 1.48 8.22
41 INT44816 Regulation of Serpina6 16 0.62 3.63 8.02
42 INT3803 Negative_regulation of Igf1 45 0.58 15.95 7.98
43 INT15687 Regulation of ESR1 91 0.60 40.42 7.95
44 INT66318 Gene_expression of NR3C1 26 0.76 20 7.55
45 INT49749 Negative_regulation of Nr3c1 13 0.43 6.25 7.36
46 INT22834 Negative_regulation of CYP21A2 28 0.58 23.07 7.13
47 INT63057 Regulation of CYP3A4 31 0.61 5.75 6.92
48 INT31333 Gene_expression of Esr2 19 0.69 8.78 6.83
49 INT142344 Transcription of Igf1 22 0.69 7.55 6.77
50 INT110987 Transcription of ESR1 45 0.71 24.16 6.72
51 INT12314 Negative_regulation of Nr3c2 16 0.56 14.82 6.72
52 INT50387 Negative_regulation of AR 67 0.45 26.31 6.61
53 INT96218 Positive_regulation of Pgr 17 0.68 5.23 6.57
54 INT14560 Regulation of Igf1 41 0.59 19.59 6.3
55 INT22901 Negative_regulation of Gene_expression of Esr1 30 0.42 20.92 6.29
56 INT9494 Positive_regulation of Gene_expression of Igf1 34 0.67 17.77 6.26
57 INT7564 Positive_regulation of Nr3c1 16 0.68 4.98 6.25
58 INT9495 Negative_regulation of Gene_expression of Igf1 31 0.59 11.87 6.1
59 INT9321 Transcription of Igf1 25 0.69 10.2 6.08
60 INT38686 Binding of NR3C1 20 0.48 9.25 5.99
61 INT52819 Negative_regulation of NR3C1 14 0.50 7.22 5.84
62 INT8916 Regulation of Igf1 45 0.60 13.06 5.81
63 INT151032 Localization of Igf1 49 0.76 26.32 5.71
64 INT20280 Positive_regulation of Esr1 32 0.69 18.37 5.69
65 INT60475 Gene_expression of Ugt1a1 17 0.77 4.26 5.62
66 INT43997 Positive_regulation of Gene_expression of Esr1 57 0.51 36.66 5.51
67 INT52814 Negative_regulation of Nr3c1 9 0.57 5.69 5.41
68 INT77252 Gene_expression of Nr3c1 17 0.67 9.71 5.38
69 INT99091 Regulation of AR 70 0.45 31.68 5.05
70 INT16621 Negative_regulation of Esr1 20 0.54 8.2 4.84
71 INT114718 Positive_regulation of Gene_expression of CYP3A4 17 0.49 4.69 4.69
72 INT37652 Positive_regulation of Pgr 29 0.59 9.09 4.67
73 INT5205 Localization of AR 43 0.80 12.87 4.63
74 INT84727 Negative_regulation of Gene_expression of AR 38 0.58 12.46 4.63
75 INT133630 Negative_regulation of Gene_expression of ESR1 42 0.52 23.89 4.57
76 INT52818 Localization of NR3C1 13 0.69 7.65 4.57
77 INT55552 Regulation of Gene_expression of Nr3c2 5 0.59 5.93 4.53
78 INT14557 Negative_regulation of Igf1 96 0.59 54.83 4.45
79 INT88947 Positive_regulation of Gene_expression of Pgr 22 0.64 7 4.39
80 INT125282 Negative_regulation of Positive_regulation of NR3C1 3 0.57 0.54 4.31
81 INT20052 Negative_regulation of UGT1A1 12 0.58 4.51 4.29
82 INT49360 Localization of Igf1 22 0.76 6.96 4.26
83 INT117205 Transcription of Esr1 23 0.65 9.4 4.14
84 INT49712 Regulation of Nr3c1 10 0.28 5.65 4.06
85 INT158593 Negative_regulation of Negative_regulation of CYP3A4 5 0.43 1.16 4.01
86 INT77385 Gene_expression of Esr2 18 0.75 4.69 3.92
87 INT179261 Gene_expression of SERPINA6 12 0.14 3.53 3.82
88 INT142174 Regulation of Gene_expression of Igf1 28 0.60 11.86 3.77
89 INT218955 Protein_catabolism of ESR1 9 0.92 3.95 3.74
90 INT39199 Positive_regulation of Ugt1a1 9 0.45 1.78 3.69
91 INT25200 Positive_regulation of GPER 13 0.05 1.75 3.67
92 INT20461 Binding of Esr1 34 0.48 9.58 3.66
93 INT5204 Positive_regulation of Gene_expression of AR 60 0.67 23.54 3.53
94 INT76399 Binding of Serpina6 4 0.34 3.81 3.46
95 INT131165 Positive_regulation of Gene_expression of Nr3c1 8 0.70 7.18 3.44
96 INT178631 Phosphorylation of ESR1 21 0.75 9.16 3.36
97 INT57252 Negative_regulation of PGR 22 0.43 12.95 3.33
98 INT19211 Binding of Shbg 35 0.48 16.29 3.31
99 INT65120 Regulation of Ugt1a1 3 0.45 1.07 3.29
100 INT10353 Positive_regulation of PGR 34 0.70 21.84 3.28
101 INT105537 Regulation of Gene_expression of Igf1 15 0.58 6.97 3.23
102 INT2629 Localization of Shbg 27 0.72 15.12 3.2
103 INT73918 Transcription of Esr1 21 0.66 8.74 3.12
104 INT7571 Transcription of Nr3c2 6 0.58 2.15 3.03
105 INT10553 Regulation of GPER 13 0.15 2.12 3.02
106 INT100785 Protein_catabolism of CYP3A4 7 1.00 0.76 3.01
107 INT45673 Gene_expression of Serpina6 10 0.53 3.47 3
108 INT28893 Positive_regulation of Atp5o 3 0.43 0.27 2.9
109 INT132760 Gene_expression of Pgr 47 0.66 28.17 2.85
110 INT32935 Binding of Pgrmc1 4 0.21 1.14 2.84
111 INT31541 Regulation of Esr1 15 0.54 4.12 2.82
112 INT60339 Gene_expression of CYP21A2 8 0.66 4.04 2.77
113 INT155216 Negative_regulation of Gene_expression of CYP3A4 9 0.56 3.81 2.71
114 INT174727 Positive_regulation of Positive_regulation of ESR1 14 0.44 6.3 2.7
115 INT77250 Positive_regulation of Gene_expression of Nr3c1 4 0.44 3.32 2.64
116 INT136105 Regulation of Pgr 4 0.45 1.93 2.62
117 INT7574 Positive_regulation of Transcription of Nr3c2 4 0.54 1.26 2.52
118 INT185927 Positive_regulation of Positive_regulation of AR 12 0.34 6.35 2.5
119 INT139735 Positive_regulation of Transcription of Igf1 4 0.53 1.93 2.49
120 INT110284 Negative_regulation of Positive_regulation of Nr3c2 4 0.53 2.08 2.48
121 INT66544 Binding of Igf1 23 0.46 8.33 2.44
122 INT88225 Transcription of Ugt1a1 5 0.61 1.51 2.4
123 INT43880 Binding of Scgb1d2 10 0.48 0.33 2.39
124 INT122709 Localization of CYP3A4 16 0.75 5.41 2.38
125 INT108796 Binding of ESR2 5 0.46 6.84 2.36
126 INT34830 Regulation of PGR 14 0.45 6.99 2.32
127 INT8484 Localization of Nr3c1 8 0.53 3.12 2.32
128 INT102234 Gene_expression of ESR2 17 0.65 9.29 2.3
129 INT54615 Gene_expression of GPER 25 0.75 8.23 2.27
130 INT71490 Positive_regulation of Positive_regulation of Serpina6 3 0.70 0.16 2.27
131 INT22605 Regulation of Pgr 22 0.62 7.1 2.26
132 INT178632 Regulation of Gene_expression of Pgr 11 0.35 1.56 2.26
133 INT83236 Localization of PGR 14 0.73 8.26 2.23
134 INT13267 Binding of Pgr 15 0.40 3.5 2.22
135 INT55365 Regulation of Binding of Nr3c2 2 0.56 0.85 2.2
136 INT55364 Negative_regulation of Binding of Nr3c2 2 0.39 0.87 2.17
137 INT125281 Positive_regulation of Positive_regulation of NR3C1 1 0.49 0 2.11
138 INT68496 Binding of PGR 26 0.48 16.36 2.09
139 INT51316 Regulation of NR3C1 7 0.51 4.23 2.09
140 INT45672 Negative_regulation of Serpina6 5 0.43 1.66 2.08
141 INT99039 Negative_regulation of Gene_expression of Nr3c1 2 0.37 1.96 2.08
142 INT117898 Positive_regulation of Protein_catabolism of CYP3A4 1 0.67 0 2.08
143 INT99410 Positive_regulation of UGT1A1 10 0.45 2.2 2.07
144 INT83744 Gene_expression of SULT1E1 9 0.75 3.12 2.07
145 INT149263 Regulation of Negative_regulation of CYP3A4 4 0.44 1 2.03
146 INT135692 Localization of Nr3c2 7 0.77 4.14 1.98
147 INT156666 Positive_regulation of Localization of Igf1 11 0.62 6.94 1.95
148 INT142341 Positive_regulation of Transcription of Igf1 8 0.49 2.44 1.95
149 INT135313 Regulation of Gene_expression of Nr3c1 3 0.39 3.44 1.94
150 INT109800 Binding of Esr2 8 0.42 1.79 1.93
151 INT73913 Regulation of Gene_expression of Esr1 2 0.41 2.24 1.92
152 INT34812 Localization of Pgrmc1 4 0.41 1.67 1.91
153 INT52305 Binding of Nr3c1 7 0.15 3.95 1.9
154 INT218959 Negative_regulation of Protein_catabolism of ESR1 3 0.37 0.97 1.9
155 INT93886 Positive_regulation of Gene_expression of PGR 19 0.52 15.78 1.89
156 INT167456 Regulation of Gene_expression of Nr3c1 2 0.14 0.76 1.87
157 INT16202 Negative_regulation of Positive_regulation of Shbg 8 0.58 5.24 1.86
158 INT148944 Transcription of UGT1A1 3 0.59 0.07 1.84
159 INT90315 Positive_regulation of Gene_expression of Nr3c2 4 0.55 2 1.83
160 INT33845 Binding of GPER 20 0.36 5.61 1.81
161 INT95397 Gene_expression of Pgrmc1 6 0.35 2.98 1.81
162 INT122346 Gene_expression of Hsd3b1 1 0.75 0 1.78
163 INT26750 Positive_regulation of Nr3c1 6 0.46 5.46 1.75
164 INT96216 Negative_regulation of Positive_regulation of Pgr 2 0.37 0.74 1.72
165 INT29598 Binding of Cyp21a1 5 0.31 0.09 1.71
166 INT153918 Binding of Esr2 3 0.33 2.56 1.7
167 INT84722 Regulation of Gene_expression of AR 20 0.61 7.73 1.69
168 INT96971 Positive_regulation of Gene_expression of Esr1 6 0.46 2.27 1.67
169 INT30076 Negative_regulation of Esr2 1 0.01 0 1.63
170 INT32688 Positive_regulation of Gene_expression of Shbg 14 0.45 7.01 1.6
171 INT222089 Positive_regulation of Localization of Esr1 19 0.49 8.73 1.58
172 INT132761 Negative_regulation of Pgr 6 0.50 3.07 1.58
173 INT45711 Localization of Pgr 7 0.61 1.27 1.56
174 INT49448 Positive_regulation of Positive_regulation of Nr3c1 1 0.38 0 1.55
175 INT49361 Regulation of Positive_regulation of Igf1 2 0.45 2.15 1.49
176 INT44288 Binding of Ugt1a1 7 0.45 0.54 1.48
177 INT128865 Regulation of Positive_regulation of RXRA 1 0.08 0.64 1.48
178 INT88224 Positive_regulation of Transcription of Ugt1a1 1 0.29 0.54 1.48
179 INT78889 Binding of UGT1A1 10 0.47 3.41 1.47
180 INT7578 Transcription of Nr3c1 5 0.32 0.43 1.47
181 INT128863 Positive_regulation of RXRA 1 0.12 0.63 1.47
182 INT96324 Negative_regulation of Gene_expression of Nr3c2 3 0.56 1.01 1.43
183 INT135959 Negative_regulation of Gene_expression of Igf1 37 0.56 21.16 1.41
184 INT187617 Binding of Rxrb 7 0.06 4.86 1.37
185 INT90491 Binding of Igf1 25 0.44 9.75 1.36
186 INT82932 Transcription of AR 14 0.67 5.75 1.34
187 INT122345 Positive_regulation of Gene_expression of Hsd3b1 1 0.49 0 1.34
188 INT10576 Gene_expression of Cyp21a1 7 0.44 1.62 1.32
189 INT117897 Negative_regulation of Protein_catabolism of CYP3A4 1 0.55 0 1.28
190 INT158078 Gene_expression of Gper 7 0.67 1.13 1.26
191 INT8511 Localization of Esr1 6 0.80 3.27 1.26
192 INT132577 Binding of RXRB 12 0.30 6.58 1.25
193 INT245636 Regulation of Positive_regulation of Nr3c2 2 0.59 1.55 1.25
194 INT179257 Binding of SERPINA6 5 0.10 2.09 1.24
195 INT128752 Negative_regulation of Localization of Esr1 11 0.43 4.8 1.23
196 INT177629 Negative_regulation of SERPINA6 5 0.57 2.1 1.22
197 INT213379 Phosphorylation of AR 6 0.63 2.03 1.21
198 INT824 Negative_regulation of Negative_regulation of ESR1 3 0.42 1.53 1.18
199 INT92826 Gene_expression of Esrrb 3 0.75 1.58 1.18
200 INT142616 Negative_regulation of Positive_regulation of Igf1 5 0.43 1.56 1.16
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