GO:0005506

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Name iron ion binding
Categary Function
Go Slim No
Go Link GO:0005506
Unique Molecular Interactions 741
Total Molecular Interactions 984
Total Single Events 10230
Pain Genes Associated 72

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for iron ion binding. They are ordered first by their pain relevance and then by number of times they were reported for iron ion binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT317517 Binding of Nos1 and Oprm1 1 0.17 0.22 3.85
2 INT317522 Akt1 Positive_regulation of Phosphorylation of Nos1 1 0.43 0.4 3.13
3 INT251150 Binding of Nos1 and Dlg2 1 0.30 1.98 2.62
4 INT104219 SCD Positive_regulation of Cnr1 1 0.00 2.67 2.54
5 INT104218 SCD Positive_regulation of CNR2 1 0.01 2.67 2.54
6 INT155984 Il1a Negative_regulation of Gene_expression of Cyp3a11 1 0.24 0.92 2.2
7 INT53751 Positive_regulation of Cyp2e1 Positive_regulation of RYBP 1 0.14 0.89 1.98
8 INT129903 Nr1i2 Regulation of Cyp3a11 1 0.64 1.26 1.9
9 INT349658 Nos2 Regulation of Gene_expression of Nos1 1 0.63 2.86 1.84
10 INT37840 Binding of Cyp27b1 and Oprd1 1 0.01 0 1.73
11 INT168612 Negative_regulation of Nos1 Negative_regulation of Positive_regulation of Mmp9 1 0.23 0.45 1.62
12 INT168607 Negative_regulation of Nos1 Negative_regulation of Mmp9 1 0.23 0.45 1.61
13 INT168611 Binding of Mmp9 and Ndor1 1 0.29 0.41 1.57
14 INT100784 RYBP Positive_regulation of CYP3A4 1 0.44 0 1.54
15 INT123899 Binding of CYP3A4 and UGT2B7 1 0.52 0 1.46
16 INT126639 KNG1 Positive_regulation of Alox15 1 0.17 0.62 1.36
17 INT106070 Positive_regulation of Oprl1 Positive_regulation of TH 1 0.13 0.15 1.36
18 INT126640 Negative_regulation of KNG1 Positive_regulation of Alox15 1 0.14 0.62 1.36
19 INT135830 Gch1 Regulation of Nos2 1 0.65 0 1.29
20 INT132465 Ltf Positive_regulation of Nos1 1 0.35 0.05 1.24
21 INT283426 Binding of Lcn2 and Nt5e 1 0.08 5.8 1.24
22 INT90644 Slc6a3 Positive_regulation of Th 1 0.51 0 1.2
23 INT25026 PLOD1 Regulation of FSHR 4 0.19 0.38 1.15
24 INT35399 Binding of Alox5 and Mthfs 1 0.01 0 1.14
25 INT106069 TH Positive_regulation of Th 1 0.07 0.16 1.14
26 INT68160 Alox5 Positive_regulation of Positive_regulation of Pla2g1b 1 0.03 0.64 1.13
27 INT110671 Binding of Cnr1 and Alox5 1 0.07 0.2 1.13
28 INT68164 Mthfs Positive_regulation of Positive_regulation of Alox5 1 0.00 0.64 1.13
29 INT68167 Alox5 Positive_regulation of Positive_regulation of Mthfs 1 0.00 0.64 1.13
30 INT110669 Binding of Alox5 and Trpv1 1 0.07 0.2 1.13
31 INT68157 Alox5 Positive_regulation of Positive_regulation of Pdpk1 1 0.01 0.64 1.13
32 INT68156 Pla2g1b Positive_regulation of Positive_regulation of Alox5 1 0.03 0.64 1.13
33 INT68165 Alox5 Positive_regulation of Pdpk1 1 0.01 0.63 1.12
34 INT142572 D5Pas1 Negative_regulation of Nos1 2 0.02 0.14 1.11
35 INT317527 Binding of Hint1 and Nos1 1 0.27 0.1 1.11
36 INT264988 Binding of CYP2C19 and CYP3A4 1 0.18 0.72 1.09
37 INT61687 Binding of Pah and Slc3a1 1 0.00 0.11 1.09
38 INT44838 Pitpnm1 Negative_regulation of Th 1 0.02 0 1.09
39 INT264987 Binding of CYP2C9 and CYP3A4 1 0.19 0.71 1.08
40 INT77083 Das Negative_regulation of Cyp2e1 1 0.20 0.59 1.06
41 INT312097 ELANE Regulation of ALOX5 1 0.08 1.75 1.05
42 INT221 Chd7 Negative_regulation of Th 1 0.02 0 1.04
43 INT132464 Ltf Negative_regulation of Positive_regulation of Nos1 1 0.33 0 1.03
44 INT70105 SCD Positive_regulation of Oprm1 1 0.01 0 1
45 INT317555 Nos1 Regulation of Negative_regulation of Oprm1 1 0.21 0.07 1
46 INT53750 Cyp2e1 Positive_regulation of RYBP 1 0.14 0.44 0.99
47 INT317567 Binding of Akt1 and Nos1 1 0.22 0 0.96
48 INT155985 Nfkb1 Negative_regulation of Gene_expression of Cyp11a1 1 0.10 0.53 0.95
49 INT146579 Hba Negative_regulation of Gene_expression of Nos2 1 0.44 1.01 0.95
50 INT165280 Tnf Positive_regulation of Gene_expression of Nos2 1 0.24 1.02 0.91
51 INT185417 Binding of ALOX5 and PLA2G2A 4 0.16 3.13 0.9
52 INT317530 Negative_regulation of Binding of Nos1 and Oprm1 1 0.21 0.06 0.9
53 INT56274 RYBP Negative_regulation of Cyp2e1 1 0.01 0.17 0.9
54 INT56273 RYBP Negative_regulation of Cyp1a2 1 0.01 0.17 0.9
55 INT101259 Gata6 Negative_regulation of Gene_expression of ALOX15 1 0.42 0.67 0.89
56 INT48455 Scd1 Regulation of Penk 1 0.06 0 0.88
57 INT184916 Binding of da and Th 1 0.09 1.22 0.87
58 INT101258 Gene_expression of Gata6 Negative_regulation of Positive_regulation of ALOX15 1 0.42 0.65 0.87
59 INT44442 GNRH1 Positive_regulation of Localization of PLOD1 3 0.50 0.78 0.86
60 INT160412 Tat Positive_regulation of Transcription of Nos2 1 0.37 0.98 0.86
61 INT37839 Positive_regulation of Binding of Cyp27b1 and Oprd1 1 0.01 0 0.86
62 INT70670 Scd1 Positive_regulation of Gene_expression of Penk 1 0.11 0.1 0.86
63 INT188318 MCPH1 Positive_regulation of Pah 3 0.02 3 0.85
64 INT120825 Adcyap1 Positive_regulation of Localization of Nos1 1 0.26 0.62 0.85
65 INT110315 Negative_regulation of ALOX5 Negative_regulation of Gene_expression of TNF 1 0.47 0.74 0.85
66 INT129881 Binding of Calr and Cbll1 1 0.00 0.58 0.84
67 INT34740 BID Regulation of Gene_expression of PLOD1 1 0.01 0 0.83
68 INT122687 Binding of Galr2 and Th 1 0.13 0.07 0.83
69 INT122688 Binding of Galr1 and Th 1 0.14 0.07 0.83
70 INT122686 Binding of Galr3 and Th 1 0.14 0.07 0.83
71 INT152236 Tlr4 Regulation of Gene_expression of Nos2 3 0.19 0.64 0.82
72 INT56275 RYBP Positive_regulation of Negative_regulation of Cyp1a2 1 0.01 0.17 0.81
73 INT352201 Negative_regulation of ALOX5 Negative_regulation of Cpox 1 0.02 0.89 0.81
74 INT349657 Nos2 Regulation of Regulation of Nos1 1 0.24 0.9 0.8
75 INT168455 Sult1a1 Negative_regulation of Nos2 1 0.08 1.99 0.79
76 INT168456 Arr3 Positive_regulation of Nos2 1 0.21 1.98 0.79
77 INT132889 Nfkb1 Regulation of Gene_expression of Nos2 1 0.16 0.21 0.79
78 INT132894 CHUK Regulation of Gene_expression of Nos2 1 0.00 0.21 0.79
79 INT203164 PTGER2 Regulation of ALOX5 1 0.00 0.9 0.78
80 INT100783 Binding of CYP2B6 and CYP3A4 2 0.17 2 0.77
81 INT203171 PTGER2 Negative_regulation of ALOX5 1 0.01 0.89 0.77
82 INT184918 da Positive_regulation of Negative_regulation of Th 1 0.14 0.14 0.77
83 INT56272 Cyp2e1 Positive_regulation of Cyp1a2 1 0.52 0.17 0.77
84 INT147278 Negative_regulation of Calca Positive_regulation of Th 1 0.41 0.76 0.74
85 INT159593 Regulation of Nfkb1 Positive_regulation of Gene_expression of Nos2 1 0.38 0.46 0.74
86 INT316673 Binding of CALR and LRP1 1 0.39 1.89 0.74
87 INT147277 Calca Positive_regulation of Th 1 0.48 0.76 0.74
88 INT213026 Hdl1 Positive_regulation of Nos3 5 0.16 7.92 0.73
89 INT45822 Pah Positive_regulation of Localization of Ins1 1 0.01 0.3 0.73
90 INT189303 Atp6v1e1 Positive_regulation of Gene_expression of TPH1 1 0.01 0.16 0.73
91 INT314203 Nos2 Positive_regulation of Gli3 1 0.19 1.27 0.73
92 INT144367 Gdnf Negative_regulation of Positive_regulation of Th 1 0.11 0.77 0.7
93 INT159569 Negative_regulation of Alox5 Negative_regulation of Gene_expression of Fos 1 0.37 0.4 0.7
94 INT149983 Binding of Cpox and Nos2 1 0.30 0.54 0.69
95 INT154766 Nox1 Positive_regulation of Localization of Prkce 1 0.47 0.45 0.66
96 INT308668 Akt1 Positive_regulation of Nos3 3 0.05 4.61 0.65
97 INT135829 Cat2 Regulation of Nos2 1 0.47 0 0.65
98 INT313435 Syp Regulation of Th 1 0.43 1.6 0.64
99 INT318981 Binding of CALR and GOPC 1 0.03 0.77 0.64
100 INT76026 Binding of Cyp2e1 and Cyp3a11 1 0.28 0.42 0.64
101 INT45780 GNRH1 Positive_regulation of PLOD1 3 0.07 1.02 0.63
102 INT158362 Tnf Positive_regulation of Steap4 1 0.55 1.6 0.61
103 INT230734 Negative_regulation of Binding of EDNRA and Pah 1 0.02 3.26 0.61
104 INT37555 FDX1 Positive_regulation of Regulation of Avp 1 0.04 0 0.61
105 INT85489 IRF6 Negative_regulation of PLOD1 1 0.01 0.16 0.61
106 INT85488 Negative_regulation of IRF6 Negative_regulation of PLOD1 1 0.01 0.16 0.61
107 INT45781 Regulation of GNRH1 Positive_regulation of PLOD1 1 0.06 0.16 0.61
108 INT35154 PLOD1 Regulation of PRL 2 0.17 0 0.6
109 INT230735 Binding of EDNRA and Pah 1 0.02 3.22 0.6
110 INT315334 Binding of CYP3A4 and CDIPT 3 0.04 0.85 0.59
111 INT270100 Negative_regulation of Binding of ALOX5 and PLA2G2A 1 0.01 0.51 0.59
112 INT35398 Fnd3c2 Negative_regulation of Binding of Alox5 1 0.00 0 0.58
113 INT212813 Tlr4 Positive_regulation of Nos2 3 0.34 0.89 0.57
114 INT75490 LEPRE1 Positive_regulation of Gene_expression of COL7A1 1 0.03 0.52 0.57
115 INT270102 ALOX5 Negative_regulation of PLA2G2A 1 0.01 0.49 0.57
116 INT142571 Pnoc Positive_regulation of Nos1 1 0.52 0.06 0.57
117 INT160156 Tph2 Regulation of Htr1a 1 0.30 0.75 0.56
118 INT23485 HBE1 Positive_regulation of Localization of PLOD1 1 0.04 0 0.54
119 INT23482 HBE1 Positive_regulation of PLOD1 1 0.04 0 0.53
120 INT228852 Th Positive_regulation of Vta1 1 0.04 0 0.53
121 INT70244 POMC Positive_regulation of Localization of PLOD1 1 0.21 0 0.53
122 INT23484 Positive_regulation of HBE1 Positive_regulation of PLOD1 1 0.04 0 0.53
123 INT228851 Th Positive_regulation of Mtf2 1 0.02 0 0.52
124 INT184922 Negative_regulation of Th Negative_regulation of da 1 0.12 0.18 0.52
125 INT283434 Lcn2 Positive_regulation of Localization of IL8 1 0.07 1.33 0.51
126 INT308656 Pik3r1 Positive_regulation of Nos3 1 0.02 1.8 0.5
127 INT317537 Oprm1 Positive_regulation of Phosphorylation of Nos1 1 0.16 0 0.5
128 INT39248 NPL Regulation of PLOD1 1 0.14 0.16 0.49
129 INT330107 Racgap1 Regulation of Positive_regulation of Nox3 1 0.01 0.87 0.49
130 INT121944 Nr1i2 Positive_regulation of Gene_expression of Cyp3a11 1 0.78 0.43 0.49
131 INT212806 Rngtt Negative_regulation of Gene_expression of Nos2 1 0.03 0.9 0.49
132 INT116337 Binding of GRIN1 and NDOR1 1 0.03 0 0.48
133 INT251163 Gene_expression of Alox5 Positive_regulation of Trpv1 1 0.02 0.11 0.48
134 INT257220 Binding of Nos1 and Flvcr2 1 0.00 0.17 0.47
135 INT312112 ELANE Regulation of Transcription of ALOX5 1 0.09 0.82 0.47
136 INT149652 Zfp36 Regulation of Nos2 1 0.09 0.42 0.47
137 INT314200 Positive_regulation of Binding of Nos2 and Tnf 1 0.42 0.34 0.46
138 INT314201 Binding of Nos2 and Tnf 1 0.31 0.33 0.46
139 INT334180 Tdo2 Negative_regulation of Tbpl1 1 0.10 0.16 0.45
140 INT123897 Binding of CYP3A4 and SLC35A2 1 0.39 0 0.45
141 INT262155 Nr5a2 Positive_regulation of Cyp7a1 1 0.07 0.24 0.45
142 INT208910 Ubl4 Regulation of Regulation of FDX1 1 0.01 0.85 0.45
143 INT354981 Cacna1a Negative_regulation of Gene_expression of Nos2 1 0.01 0.99 0.45
144 INT249021 Gabrg1 Negative_regulation of Th 1 0.08 0.06 0.44
145 INT116610 Positive_regulation of Lnpep Regulation of Nos2 1 0.16 0.62 0.44
146 INT116608 Lnpep Regulation of Nos2 1 0.14 0.62 0.44
147 INT43365 Scd1 Negative_regulation of Gnrh1 1 0.13 0.1 0.44
148 INT158267 Olr1745 Negative_regulation of Alox5 1 0.05 0.94 0.43
149 INT212809 Il6 Positive_regulation of Gene_expression of Nos2 1 0.08 0.75 0.43
150 INT212810 Tlr4 Positive_regulation of Gene_expression of Nos2 1 0.03 0.74 0.43
151 INT159349 Zfp956 Negative_regulation of Nos1 1 0.03 0.61 0.43
152 INT43587 Binding of OPRD1 and Pah 1 0.00 0.08 0.43
153 INT23481 POMC Regulation of Localization of PLOD1 1 0.20 0 0.42
154 INT76154 Binding of NCOR2 and Negative_regulation of Localization of PLOD1 1 0.02 0 0.42
155 INT116611 Lnpep Positive_regulation of Binding of Nos2 1 0.16 0.62 0.42
156 INT111410 Nos1 Regulation of Vip 1 0.00 0 0.41
157 INT135972 Nfkb1 Positive_regulation of Gene_expression of Nos2 1 0.04 0.54 0.41
158 INT147280 Binding of Pecam1 and Th 1 0.29 0.41 0.41
159 INT203163 LTB4R Regulation of Gene_expression of ALOX5 1 0.00 0.98 0.41
160 INT111409 Nos1 Regulation of Gene_expression of Vip 1 0.01 0 0.41
161 INT123898 CYP3A4 Regulation of UGT2B7 1 0.22 0 0.41
162 INT156438 Cpox Positive_regulation of Nos2 3 0.14 1.24 0.4
163 INT159571 Trpv1 Positive_regulation of Gene_expression of Alox5 1 0.37 0.58 0.4
164 INT77924 Binding of SCD and Oprd1 1 0.00 0.25 0.4
165 INT139683 Binding of Cldn11 and 2410016O06Rik 1 0.02 1.06 0.4
166 INT139684 Binding of Cd4 and 2410016O06Rik 1 0.02 1.05 0.4
167 INT77923 Negative_regulation of Binding of SCD and Oprd1 1 0.00 0.25 0.4
168 INT262186 Nr0b2 Positive_regulation of Negative_regulation of Cyp7a1 1 0.12 0.28 0.4
169 INT302871 Negative_regulation of Adora2a Positive_regulation of Phosphorylation of Th 1 0.26 0.12 0.4
170 INT312123 ELANE Positive_regulation of ALOX5 1 0.09 0.74 0.4
171 INT43366 Scd1 Regulation of Gene_expression of Gnrh1 1 0.08 0.07 0.39
172 INT43367 Scd1 Regulation of Gnrh1 1 0.08 0.07 0.39
173 INT43363 Scd1 Regulation of Barhl1 1 0.03 0.07 0.39
174 INT201274 Car2 Regulation of Gene_expression of Nos1 1 0.05 1.15 0.38
175 INT273617 Gene_expression of Slc6a4 Positive_regulation of Pah 1 0.02 0.93 0.38
176 INT262205 Positive_regulation of Nr1i2 Positive_regulation of Gene_expression of Cyp3a11 1 0.33 0.11 0.38
177 INT158355 Cacna1a Regulation of Alox5 1 0.01 0.7 0.37
178 INT316675 Binding of CALR and SFTPD 1 0.35 0.96 0.37
179 INT168426 RYBP Regulation of Nos2 1 0.01 0.4 0.36
180 INT352821 Tph2 Regulation of Tst 1 0.31 0.46 0.36
181 INT262182 Positive_regulation of Nr1i2 Negative_regulation of Gene_expression of Cyp7a1 1 0.23 0.36 0.36
182 INT168424 Ptger2 Regulation of Binding of Nos2 1 0.22 0.52 0.36
183 INT152240 Nfasc Regulation of Gene_expression of Nos2 1 0.06 0.19 0.36
184 INT168423 Ptger2 Regulation of Nos2 1 0.13 0.52 0.36
185 INT312102 Binding of ALOX5 and ALOX5AP 1 0.10 0.65 0.36
186 INT261597 Binding of PAH and COPD 1 0.00 1.08 0.34
187 INT175319 Negative_regulation of Nos2 Negative_regulation of Positive_regulation of Pnlip 1 0.01 0.83 0.34
188 INT105768 Binding of Nos1 and Nqo1 1 0.00 0.26 0.34
189 INT354985 Cacna1a Regulation of Nos2 1 0.01 0.73 0.34
190 INT43388 OPRM1 Positive_regulation of Localization of PLOD1 1 0.27 0 0.34
191 INT110758 Tnfaip8 Positive_regulation of Positive_regulation of Nos2 1 0.14 0.88 0.34
192 INT144448 Nqo1 Regulation of Nos1 1 0.11 0.09 0.34
193 INT303126 Nos2 Positive_regulation of Gene_expression of Il6 1 0.13 4.38 0.34
194 INT144450 Regulation of Nqo1 Regulation of Nos1 1 0.11 0.1 0.34
195 INT39208 ALOX5 Regulation of Gene_expression of IL2 1 0.04 0.06 0.34
196 INT37554 Avp Regulation of FDX1 1 0.01 0 0.34
197 INT37553 Crh Regulation of FDX1 1 0.03 0 0.34
198 INT110761 Tnfaip8 Positive_regulation of Nos2 1 0.13 0.88 0.34
199 INT128677 Positive_regulation of Binding of TET1 and Tet2 1 0.26 0.8 0.33
200 INT128678 Binding of TET1 and Tet2 1 0.19 0.8 0.33

Single Events

The table below shows the top 100 pain related interactions that have been reported for iron ion binding. They are ordered first by their pain relevance and then by number of times they were reported in iron ion binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT66280 Gene_expression of Nos2 534 0.78 330.78 157.07
2 INT49171 Gene_expression of Nos1 241 0.78 140.7 104.76
3 INT77435 Positive_regulation of Nos2 343 0.70 208.49 91.43
4 INT920 Localization of PLOD1 223 0.81 42.25 78.7
5 INT79093 Positive_regulation of Nos1 101 0.70 46.89 59.61
6 INT49170 Negative_regulation of Nos1 116 0.59 60.66 58.87
7 INT64110 Positive_regulation of Gene_expression of Nos1 68 0.70 58.11 51.64
8 INT50405 Negative_regulation of CYP3A4 238 0.59 53.65 51.51
9 INT85943 Negative_regulation of Nos2 161 0.59 108.56 42.65
10 INT3933 Positive_regulation of PLOD1 128 0.70 30.76 42.03
11 INT65245 Gene_expression of Nos3 121 0.78 98.14 41.56
12 INT77434 Positive_regulation of Gene_expression of Nos2 151 0.69 96.76 38.94
13 INT30817 Gene_expression of Th 142 0.76 33.56 38.12
14 INT913 Regulation of Localization of PLOD1 71 0.62 8.64 32.72
15 INT92837 Negative_regulation of Gene_expression of Nos2 116 0.59 59.67 31.82
16 INT5418 Negative_regulation of Alox5 108 0.57 42.09 31.17
17 INT7975 Regulation of PLOD1 97 0.62 20.9 30.51
18 INT9053 Negative_regulation of ALOX5 97 0.58 40.34 29.94
19 INT22211 Positive_regulation of CYP3A4 110 0.70 22 28.27
20 INT12129 Gene_expression of CYP3A4 107 0.78 23.11 27.6
21 INT1638 Negative_regulation of PLOD1 92 0.59 21.69 26.61
22 INT89854 Regulation of Nos2 49 0.61 42.58 24.1
23 INT4781 Gene_expression of TH 68 0.73 26.92 24.01
24 INT49172 Regulation of Nos1 43 0.52 27.53 23.66
25 INT917 Positive_regulation of Localization of PLOD1 51 0.69 8.53 22.87
26 INT47859 Negative_regulation of Cyp2e1 41 0.59 16.92 21.72
27 INT66281 Transcription of Nos2 81 0.71 39.49 20.37
28 INT24240 Positive_regulation of Th 60 0.70 9.92 20.18
29 INT17442 Gene_expression of ALOX5 110 0.75 51.55 18.29
30 INT1642 Negative_regulation of Localization of PLOD1 40 0.58 10.67 17.95
31 INT50579 Binding of CYP3A4 84 0.48 17.52 17.45
32 INT219 Negative_regulation of Th 55 0.59 20.88 17.09
33 INT77433 Regulation of Gene_expression of Nos2 49 0.62 35.07 16.33
34 INT24241 Phosphorylation of Th 35 0.81 8.69 16.06
35 INT13716 Positive_regulation of TH 33 0.68 19.11 16
36 INT114025 Transcription of Nos1 20 0.70 16.48 15.63
37 INT7970 Gene_expression of PLOD1 120 0.71 44.42 15.54
38 INT64112 Regulation of Gene_expression of Nos1 22 0.62 21.45 14.76
39 INT109264 Positive_regulation of Transcription of Th 17 0.50 4.73 14.33
40 INT23344 Gene_expression of Alox5 60 0.75 28.2 13.82
41 INT53747 Positive_regulation of Cyp2e1 34 0.70 29.03 13.39
42 INT121242 Positive_regulation of Gene_expression of Nos3 37 0.69 31.96 12.71
43 INT73431 Positive_regulation of Nos3 82 0.65 53.22 11.61
44 INT97381 Negative_regulation of Positive_regulation of Nos2 34 0.59 16.66 11.6
45 INT80251 Binding of Nos1 21 0.30 8.24 11.31
46 INT71189 Gene_expression of Cyp1a2 24 0.78 11.39 11.12
47 INT62580 Gene_expression of Cyp2e1 31 0.78 15.4 11.08
48 INT95341 Gene_expression of NDOR1 17 0.75 4.27 10.98
49 INT78567 Positive_regulation of Gene_expression of Th 25 0.68 5.32 10.75
50 INT149015 Gene_expression of Tph2 20 0.78 9.45 10.4
51 INT110017 Phosphorylation of Nos1 12 0.60 1.64 10.3
52 INT115296 Gene_expression of TPH1 18 0.77 7.46 10.18
53 INT17421 Negative_regulation of Alox5 41 0.57 15.23 10.05
54 INT47860 Negative_regulation of Cyp1a2 20 0.57 6.06 10
55 INT53746 Regulation of Cyp2e1 11 0.62 3.82 9.52
56 INT9889 Gene_expression of Alox5 34 0.63 20.83 8.85
57 INT22965 Positive_regulation of Pah 42 0.61 41.41 8.84
58 INT109265 Transcription of Th 18 0.68 4.5 8.21
59 INT116605 Binding of Nos2 28 0.37 16.88 8.18
60 INT5114 Gene_expression of Ptgis 41 0.50 21.43 8.1
61 INT114023 Positive_regulation of Transcription of Nos1 7 0.60 5.35 8.06
62 INT71381 Localization of Nos1 33 0.79 11.46 8.05
63 INT18025 Binding of Pah 32 0.45 30.72 7.93
64 INT172789 Regulation of Gene_expression of Nos3 15 0.53 16.23 7.86
65 INT96724 Gene_expression of Cyp3a11 10 0.77 4.82 7.76
66 INT112191 Positive_regulation of Transcription of Nos2 22 0.66 12.4 7.74
67 INT85751 Positive_regulation of Positive_regulation of Nos2 40 0.60 23.53 7.72
68 INT65246 Negative_regulation of Nos3 36 0.50 25.65 7.62
69 INT248206 Gene_expression of Tdo2 15 0.78 9.17 7.16
70 INT116428 Gene_expression of Cybb 68 0.76 35.81 7.07
71 INT63057 Regulation of CYP3A4 31 0.61 5.75 6.92
72 INT76025 Positive_regulation of Cyp3a11 20 0.69 5.88 6.91
73 INT122896 Negative_regulation of TH 23 0.57 9.27 6.88
74 INT32783 Gene_expression of Pah 33 0.60 30.55 6.86
75 INT109266 Negative_regulation of Transcription of Th 9 0.42 2.5 6.85
76 INT66987 Regulation of Th 23 0.61 7.86 6.8
77 INT16720 Negative_regulation of Xdh 35 0.59 14 6.67
78 INT3506 Localization of TH 12 0.81 0.78 6.66
79 INT92741 Positive_regulation of Positive_regulation of Nos1 8 0.47 1.44 6.58
80 INT71002 Gene_expression of ALOX15 21 0.78 21.16 6.37
81 INT49468 Negative_regulation of Pah 28 0.55 24.95 6.29
82 INT93079 Positive_regulation of ALOX15 8 0.70 12.46 6.22
83 INT64111 Negative_regulation of Gene_expression of Nos1 22 0.57 8.96 6.02
84 INT3915 Gene_expression of SCD 25 0.57 13.94 6
85 INT18523 Negative_regulation of ALOX15 15 0.59 14.2 5.92
86 INT167457 Negative_regulation of Gene_expression of Tph2 5 0.57 2.27 5.9
87 INT257199 Positive_regulation of Phosphorylation of Nos1 2 0.45 0.68 5.78
88 INT62579 Negative_regulation of Gene_expression of Cyp2e1 8 0.59 2.95 5.48
89 INT28164 Regulation of ALOX5 25 0.60 12.76 5.47
90 INT30317 Regulation of TH 14 0.43 7.27 5.38
91 INT28165 Positive_regulation of ALOX5 38 0.47 10.8 5.37
92 INT112190 Regulation of Negative_regulation of Nos2 8 0.62 5.83 5.09
93 INT6577 Regulation of Alox5 18 0.47 9.19 5.06
94 INT19934 Negative_regulation of Ptgis 18 0.32 6.18 5.03
95 INT91475 Binding of NDOR1 3 0.27 0.61 4.97
96 INT49292 Positive_regulation of Cyp1a2 17 0.69 6.16 4.96
97 INT24236 Positive_regulation of Phosphorylation of Th 12 0.61 3.68 4.87
98 INT37151 Localization of Th 13 0.57 3.11 4.82
99 INT114718 Positive_regulation of Gene_expression of CYP3A4 17 0.49 4.69 4.69
100 INT30355 Positive_regulation of Gene_expression of Alox5 10 0.67 14.61 4.69
101 INT15995 Positive_regulation of Alox5 18 0.49 3.94 4.63
102 INT52088 Binding of Cyp2e1 8 0.48 2.5 4.43
103 INT126659 Gene_expression of Tph1 22 0.78 2.04 4.04
104 INT74365 Positive_regulation of Alox5 19 0.47 11.03 4.04
105 INT158593 Negative_regulation of Negative_regulation of CYP3A4 5 0.43 1.16 4.01
106 INT19158 Gene_expression of PAH 35 0.65 35.81 3.88
107 INT116349 Positive_regulation of Gene_expression of NDOR1 3 0.47 2.56 3.86
108 INT22223 Positive_regulation of Xdh 18 0.67 5.87 3.84
109 INT89606 Positive_regulation of Gene_expression of ALOX15 9 0.70 8.34 3.76
110 INT73611 Negative_regulation of SCD 15 0.37 26.67 3.71
111 INT3854 Binding of SCD 16 0.41 11.14 3.7
112 INT44254 Regulation of Gene_expression of ALOX5 12 0.43 7.06 3.65
113 INT142753 Gene_expression of Lcn2 28 0.76 10.03 3.62
114 INT4545 Negative_regulation of Nox1 15 0.53 10.08 3.4
115 INT155983 Gene_expression of Cyp11a1 7 0.58 2.6 3.38
116 INT71199 Positive_regulation of Gene_expression of Cyp1a2 4 0.69 1.41 3.36
117 INT142568 Negative_regulation of Positive_regulation of Nos1 2 0.37 0.25 3.3
118 INT4596 Positive_regulation of SCD 18 0.42 22.59 3.26
119 INT71195 Transcription of Cyp1a2 6 0.53 2.41 3.24
120 INT102901 Regulation of Gene_expression of Th 12 0.60 2.42 3.22
121 INT10476 Binding of ALOX5 26 0.36 7.69 3.2
122 INT76024 Negative_regulation of Cyp3a11 7 0.53 2.96 3.16
123 INT116235 Negative_regulation of Transcription of Nos2 23 0.58 7.91 3.14
124 INT9110 Binding of PAH 32 0.41 42.1 3.1
125 INT35448 Negative_regulation of Gene_expression of ALOX5 11 0.57 5.28 3.03
126 INT42485 Binding of Pah 9 0.35 3.42 3.03
127 INT162835 Positive_regulation of Cybb 38 0.68 16.09 3.02
128 INT100785 Protein_catabolism of CYP3A4 7 1.00 0.76 3.01
129 INT137301 Negative_regulation of Gene_expression of TPH1 5 0.12 1.49 2.98
130 INT146758 Gene_expression of LCN2 45 0.78 38.29 2.97
131 INT168604 Phosphorylation of Ndor1 1 0.68 0.75 2.97
132 INT4782 Positive_regulation of Gene_expression of TH 12 0.47 7.36 2.95
133 INT25031 Negative_regulation of Gene_expression of PLOD1 14 0.54 3.86 2.89
134 INT76342 Positive_regulation of Gene_expression of Alox5 9 0.56 5.29 2.87
135 INT14902 Negative_regulation of XDH 38 0.55 24.19 2.86
136 INT22194 Gene_expression of Xdh 20 0.75 10.03 2.83
137 INT39908 Gene_expression of Cyp27b1 16 0.69 4.8 2.83
138 INT85750 Regulation of Positive_regulation of Nos2 10 0.54 7.78 2.83
139 INT29651 Regulation of Pah 11 0.37 9.95 2.79
140 INT52084 Localization of Cyp2e1 6 0.71 1.99 2.79
141 INT155216 Negative_regulation of Gene_expression of CYP3A4 9 0.56 3.81 2.71
142 INT49169 Regulation of Negative_regulation of Nos1 3 0.45 4.67 2.7
143 INT151029 Positive_regulation of Gene_expression of Lcn2 8 0.68 4.04 2.65
144 INT106066 Negative_regulation of Positive_regulation of TH 1 0.18 0.22 2.6
145 INT248419 Negative_regulation of Tph2 11 0.59 6.32 2.59
146 INT106068 Positive_regulation of Positive_regulation of TH 1 0.21 0.22 2.59
147 INT89852 Localization of Nos2 22 0.78 14.89 2.56
148 INT127458 Positive_regulation of PAH 24 0.58 27.25 2.53
149 INT145101 Transcription of Nos3 8 0.70 6.04 2.47
150 INT34905 Positive_regulation of Gene_expression of ALOX5 18 0.50 7.46 2.46
151 INT184914 Negative_regulation of Gene_expression of Th 15 0.43 9.17 2.46
152 INT200217 Localization of PAH 10 0.36 15.51 2.46
153 INT176205 Gene_expression of Cyp7a1 8 0.69 2.5 2.45
154 INT138785 Gene_expression of Lcn2 9 0.56 9.88 2.41
155 INT54555 Negative_regulation of CALR 10 0.41 4.41 2.4
156 INT38384 Regulation of Por 5 0.47 0.58 2.4
157 INT208898 Gene_expression of FDX1 8 0.10 5.58 2.39
158 INT122709 Localization of CYP3A4 16 0.75 5.41 2.38
159 INT115298 Regulation of Gene_expression of TPH1 1 0.22 2.36 2.33
160 INT12033 Binding of PLOD1 15 0.48 8.04 2.3
161 INT73809 Regulation of Nos3 18 0.45 10.05 2.27
162 INT144792 Negative_regulation of Transcription of Nos1 2 0.43 1.74 2.27
163 INT61225 Positive_regulation of Cyp27b1 8 0.31 2.32 2.24
164 INT12131 Gene_expression of POR 17 0.77 9.42 2.17
165 INT141299 Negative_regulation of Gene_expression of Nos3 9 0.55 5.38 2.17
166 INT110016 Negative_regulation of Phosphorylation of Nos1 3 0.28 0.47 2.16
167 INT121884 Regulation of Binding of Nos1 2 0.33 1.63 2.15
168 INT169533 Positive_regulation of Gene_expression of Cybb 16 0.68 8.62 2.14
169 INT36534 Negative_regulation of Positive_regulation of PLOD1 5 0.56 1.39 2.14
170 INT120234 Positive_regulation of Gene_expression of Cyp3a11 4 0.46 2.21 2.13
171 INT75493 Gene_expression of LEPRE1 1 0.32 1.62 2.12
172 INT26736 Localization of Alox5 7 0.49 3.72 2.09
173 INT61011 Regulation of TPH1 4 0.22 1.17 2.09
174 INT117898 Positive_regulation of Protein_catabolism of CYP3A4 1 0.67 0 2.08
175 INT149263 Regulation of Negative_regulation of CYP3A4 4 0.44 1 2.03
176 INT90688 Negative_regulation of Tdo2 12 0.59 5.82 2.02
177 INT82722 Negative_regulation of Positive_regulation of Cyp2e1 6 0.59 3.74 2.02
178 INT151036 Positive_regulation of Lcn2 13 0.49 8.57 2
179 INT7974 Regulation of Gene_expression of PLOD1 6 0.42 0.41 1.99
180 INT7973 Positive_regulation of Regulation of PLOD1 5 0.42 0.42 1.99
181 INT82441 Binding of Cyp4f18 4 0.23 1.07 1.99
182 INT70526 Binding of CALR 11 0.35 7.09 1.97
183 INT7972 Positive_regulation of Gene_expression of PLOD1 15 0.42 5.73 1.96
184 INT21941 Regulation of CALR 7 0.53 3.88 1.96
185 INT59302 Positive_regulation of POR 19 0.49 15.18 1.95
186 INT20251 Binding of Alox5 7 0.32 5.33 1.93
187 INT168605 Positive_regulation of Ndor1 2 0.57 0.43 1.89
188 INT49377 Negative_regulation of Scd1 11 0.49 9.84 1.88
189 INT29577 Negative_regulation of Cyp27b1 5 0.37 2.41 1.88
190 INT76532 Binding of Nos3 13 0.37 9.32 1.87
191 INT314510 Protein_catabolism of TH 1 0.10 3.28 1.86
192 INT40215 Negative_regulation of Fech 9 0.57 8.39 1.85
193 INT96723 Regulation of Cyp3a11 5 0.44 2 1.83
194 INT3505 Binding of TH 5 0.39 2.6 1.8
195 INT61685 Positive_regulation of Gene_expression of Pah 6 0.43 4.05 1.79
196 INT19831 Binding of Ptgis 3 0.08 3.33 1.77
197 INT34552 Regulation of Gene_expression of Alox5 3 0.50 5.06 1.75
198 INT15916 Positive_regulation of Ptgis 11 0.39 6.6 1.74
199 INT39229 Regulation of Alox5 6 0.57 3.2 1.72
200 INT101257 Negative_regulation of Positive_regulation of ALOX15 1 0.41 1.47 1.71
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