GO:0005507

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Name copper ion binding
Categary Function
Go Slim No
Go Link GO:0005507
Unique Molecular Interactions 1113
Total Molecular Interactions 1413
Total Single Events 15640
Pain Genes Associated 67

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for copper ion binding. They are ordered first by their pain relevance and then by number of times they were reported for copper ion binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT206768 TP53 Positive_regulation of Ltp 2 0.01 5.83 10.21
2 INT95730 Binding of CP and SPINK1 2 0.19 5.65 4.02
3 INT275850 Binding of NDUFAB1 and SNCA 1 0.00 3.78 3.16
4 INT150889 Il1a Regulation of Il10 1 0.22 3.49 2.95
5 INT150886 Il1a Regulation of Il1b 1 0.02 3.46 2.93
6 INT150888 Il1a Regulation of Il6 1 0.10 3.47 2.93
7 INT222522 Il1a Positive_regulation of Gene_expression of Il6 2 0.06 1.79 2.79
8 INT312690 CP Positive_regulation of CCL20 1 0.11 8.23 2.2
9 INT155984 Il1a Negative_regulation of Gene_expression of Cyp3a11 1 0.24 0.92 2.2
10 INT66157 Binding of ALB and BDP1 1 0.11 0 2.13
11 INT163266 Crh Negative_regulation of Tyr 1 0.01 0.45 1.98
12 INT275851 PES1 Negative_regulation of CP 1 0.01 1.96 1.83
13 INT165183 Ifnb1 Positive_regulation of P2rx4 1 0.04 1.73 1.73
14 INT149743 Ean5 Positive_regulation of Gene_expression of P2rx2 1 0.10 1.54 1.5
15 INT44504 Mt1a Positive_regulation of Prl 1 0.37 0 1.48
16 INT61443 Binding of KNG1 and Tyr 1 0.00 0 1.46
17 INT104972 MITF Regulation of Transcription of TYR 1 0.20 0.35 1.45
18 INT39950 Binding of ALB and PDYN 1 0.31 0 1.32
19 INT42579 SOD1 Negative_regulation of POMC 1 0.16 0.43 1.27
20 INT8409 IL1A Positive_regulation of Positive_regulation of Vip 1 0.01 0.63 1.27
21 INT142431 Cp Positive_regulation of Crh 1 0.31 1.49 1.26
22 INT155663 Positive_regulation of P2rx4 Positive_regulation of Localization of Bdnf 1 0.42 0.84 1.25
23 INT98832 Th Regulation of Dbh 1 0.32 0.53 1.2
24 INT147446 ADCYAP1 Regulation of Localization of CP 1 0.02 1.12 1.16
25 INT19535 Binding of ADRA1D and ALB 3 0.42 0.8 1.15
26 INT31549 Binding of Dbh and Vip 1 0.32 0 1.08
27 INT172757 Rnpep Positive_regulation of Hps4 1 0.00 0 1.08
28 INT69874 POMC Negative_regulation of TYRP1 1 0.13 0 1.07
29 INT69871 ASIP Negative_regulation of TYRP1 1 0.36 0 1.07
30 INT266742 GOPC Regulation of Positive_regulation of ACR 1 0.02 0.36 1.05
31 INT8410 IL1A Positive_regulation of Vip 1 0.02 0.68 1.05
32 INT175553 Binding of CASR and CP 1 0.11 1.65 1.03
33 INT73681 Regulation of KNG1 Positive_regulation of ALB 1 0.30 0.38 0.99
34 INT130232 Binding of Cat and Sod1 1 0.35 0.3 0.98
35 INT31548 Binding of Th and Dbh 1 0.35 0 0.98
36 INT73680 KNG1 Positive_regulation of ALB 1 0.51 0.38 0.98
37 INT130231 Positive_regulation of Binding of Cat and Sod1 1 0.46 0.3 0.98
38 INT292530 Il10 Negative_regulation of Localization of Il1a 1 0.06 1.09 0.97
39 INT159111 Il1a Regulation of Gene_expression of Il1b 1 0.49 0.38 0.97
40 INT73461 PTPLA Positive_regulation of Transcription of TP53 1 0.06 0.99 0.96
41 INT274899 Positive_regulation of P2rx4 Positive_regulation of Localization of Gtf3a 1 0.02 1.67 0.95
42 INT163265 Sst Negative_regulation of Tyr 1 0.00 0.22 0.95
43 INT330629 TP53 Negative_regulation of Gene_expression of Fos 1 0.30 1.76 0.94
44 INT66536 Il1a Regulation of Gene_expression of Fos 1 0.59 0 0.91
45 INT78062 Il1a Positive_regulation of Localization of Il6 3 0.24 0.48 0.9
46 INT21944 Il1a Negative_regulation of Gnrh1 1 0.34 0 0.89
47 INT151779 Calca Positive_regulation of Transcription of P2rx7 1 0.02 0.54 0.87
48 INT330630 Binding of TP53 and Car1 1 0.23 1.56 0.86
49 INT215646 Binding of Adora1 and P2rx2 1 0.13 0.51 0.85
50 INT215598 Positive_regulation of P2rx7 Positive_regulation of Localization of TNF 1 0.22 1.44 0.85
51 INT222985 CP Positive_regulation of Positive_regulation of TGFB1 1 0.00 1.57 0.85
52 INT151409 Binding of Cp and Cd8b 1 0.16 0 0.84
53 INT97057 Bcl2l1 Regulation of Gene_expression of Trp53 1 0.36 0.51 0.83
54 INT97058 Cpz Regulation of Gene_expression of Trp53 1 0.27 0.57 0.83
55 INT19299 ANG Regulation of AVP 1 0.25 0 0.82
56 INT218037 Binding of ALB and Penk 1 0.13 0 0.81
57 INT110726 Binding of ALB and LTF 1 0.01 0 0.81
58 INT306271 IL1A Positive_regulation of Gene_expression of IL6 1 0.30 0.85 0.8
59 INT245350 Abat Regulation of Dbh 1 0.00 0.37 0.8
60 INT196575 Negative_regulation of Mapk14 Negative_regulation of Gene_expression of Il1a 1 0.04 0.44 0.77
61 INT200097 Negative_regulation of Binding of Il1a and Jun 1 0.00 2.76 0.77
62 INT200093 Binding of Il1a and Jun 1 0.00 2.64 0.76
63 INT37439 Binding of Shbdp1 and Tyr 1 0.01 0 0.76
64 INT250959 Binding of HLA-B and SOD1 1 0.05 0.75 0.75
65 INT44502 Regulation of Mt1a Positive_regulation of Prl 1 0.14 0 0.74
66 INT46917 Binding of Tyr and Positive_regulation of Penk 1 0.02 0 0.73
67 INT46919 Binding of Tyr and Positive_regulation of Vom1r1 1 0.00 0 0.73
68 INT296097 Acsm3 Negative_regulation of SOD1 1 0.01 1.3 0.72
69 INT5971 Il1a Positive_regulation of Crh 2 0.51 0.57 0.71
70 INT12052 Xcl1 Negative_regulation of Rnpep 1 0.01 0 0.71
71 INT205706 P2rx7 Regulation of Gene_expression of Il18 1 0.21 1.35 0.7
72 INT99172 Pomc Positive_regulation of Tyr 1 0.35 0.17 0.69
73 INT126779 Binding of Serpinc1 and F8 1 0.00 1.52 0.69
74 INT102762 Binding of POMC and TYR 1 0.12 0.35 0.69
75 INT250871 Il1a Positive_regulation of Protein_catabolism of Ecm1 1 0.01 1.44 0.68
76 INT246335 Fig4 Regulation of Localization of P2rx7 1 0.01 0 0.67
77 INT205702 P2rx7 Regulation of Gene_expression of Il1 1 0.04 1.38 0.67
78 INT94241 Binding of Cp and Slc2a2 1 0.13 0.81 0.67
79 INT101986 TP53 Positive_regulation of Gene_expression of GDF15 1 0.52 2.45 0.67
80 INT28975 Ins1 Positive_regulation of Positive_regulation of Dbh 1 0.21 0 0.66
81 INT312694 PCA Regulation of Localization of CP 1 0.05 2.65 0.66
82 INT344387 Efnb2 Positive_regulation of Phosphorylation of Tyr 1 0.01 1.05 0.66
83 INT92045 Binding of ALB and SERPINA1 1 0.30 1.37 0.64
84 INT99170 Binding of Mc1r and Tyr 1 0.11 0.2 0.64
85 INT30130 Binding of TYRP1 and Gast 1 0.06 0.09 0.63
86 INT255994 Binding of Ang and Il1rn 1 0.09 1.21 0.63
87 INT142432 Regulation of Cp Positive_regulation of Crh 1 0.18 0.75 0.63
88 INT142430 Cp Positive_regulation of Gal 1 0.30 0.74 0.62
89 INT95431 Il1a Regulation of Mmp2 1 0.48 0.25 0.61
90 INT166402 CDKN1A Regulation of Gene_expression of TP53 1 0.27 0.83 0.61
91 INT306264 Binding of IL1A and MTX1 1 0.09 0.74 0.61
92 INT95435 Il1a Positive_regulation of Positive_regulation of Mmp3 1 0.59 0.25 0.61
93 INT95436 Il1a Positive_regulation of Mmp3 1 0.59 0.25 0.61
94 INT95434 Mmp9 Positive_regulation of Positive_regulation of Il1a 1 0.42 0.23 0.61
95 INT95432 Il1a Positive_regulation of Positive_regulation of Mmp9 1 0.37 0.25 0.6
96 INT70811 Penk Negative_regulation of Binding of Tyr 1 0.01 0 0.6
97 INT222554 Il1a Positive_regulation of Localization of Ngf 1 0.02 0.07 0.6
98 INT87683 Binding of HLA-B and Prnd 1 0.00 0.59 0.59
99 INT205705 Positive_regulation of P2rx7 Positive_regulation of Gene_expression of Il6 1 0.07 1.42 0.58
100 INT94240 Binding of Cp and Ins1 1 0.02 0.7 0.58
101 INT50883 Binding of AGTR2 and ALB 1 0.37 0.19 0.56
102 INT73368 Ang1 Negative_regulation of Fabp6 1 0.00 0.44 0.56
103 INT8401 Il1a Regulation of Gene_expression of Nts 1 0.00 0.38 0.56
104 INT308174 Binding of TNF and P2rx7 1 0.02 0.84 0.56
105 INT8395 Il1a Regulation of Gene_expression of Vip 1 0.01 0.38 0.56
106 INT544 Binding of ALB and GC 1 0.13 0 0.55
107 INT114029 Binding of ALB and Mmp3 1 0.01 0.31 0.55
108 INT351581 Binding of ALB and GOPC 1 0.11 0 0.55
109 INT114028 Negative_regulation of Binding of ALB and Mmp3 1 0.01 0.31 0.55
110 INT255999 Binding of Ang and H7 1 0.00 0.38 0.54
111 INT10079 Cp Regulation of Trh 1 0.01 0.59 0.53
112 INT8396 Il1a Regulation of Nts 1 0.00 0.38 0.53
113 INT8399 Il1a Regulation of Vip 1 0.00 0.38 0.53
114 INT185490 Atp5o Negative_regulation of Gene_expression of P2rx7 1 0.01 0.87 0.53
115 INT160829 Tyr Regulation of RYBP 1 0.04 0.75 0.53
116 INT254200 Mif Regulation of Trp53 1 0.02 0.96 0.52
117 INT139750 Ubqln1 Regulation of Dbh 1 0.00 0 0.52
118 INT216941 P2rx7 Regulation of Ryr1 1 0.01 0.55 0.52
119 INT139751 Dbh Regulation of Localization of Prl 1 0.02 0 0.52
120 INT278122 Negative_regulation of P2rx7 Negative_regulation of Binding of P2RX7 1 0.03 0 0.51
121 INT27730 Binding of ALB and Shbg 2 0.01 0.44 0.5
122 INT352521 Cnn1 Positive_regulation of Cp 1 0.00 1.45 0.5
123 INT274625 OPN1MW Positive_regulation of SOD1 1 0.19 0.29 0.5
124 INT31531 Mif-ps1 Regulation of TYR 1 0.11 0 0.49
125 INT129911 Skiv2l Negative_regulation of Localization of IL1A 1 0.01 0.74 0.48
126 INT229128 Binding of CP and PRSS1 1 0.14 0.77 0.47
127 INT168110 Binding of Cnr1 and Dbh 1 0.04 0.64 0.47
128 INT130723 Binding of IL1A and Il1rn 1 0.01 0.59 0.47
129 INT130724 Negative_regulation of Binding of IL1A and Il1rn 1 0.01 0.59 0.47
130 INT168111 Dbh Positive_regulation of Cnr1 1 0.05 0.64 0.47
131 INT19297 ANG Positive_regulation of AVP 1 0.28 0 0.46
132 INT310769 Pam Regulation of Tlr4 1 0.01 0.69 0.46
133 INT168699 Binding of Nedd4 and Tyr 1 0.02 0.45 0.46
134 INT222283 Negative_regulation of Casp1 Negative_regulation of Il1a 1 0.00 0.78 0.46
135 INT239474 Binding of ACR and Ifx 1 0.02 0.36 0.45
136 INT241914 SOD1 Positive_regulation of Ros1 1 0.00 0.76 0.44
137 INT157451 Binding of Slc6a3 and Dbh 1 0.04 0.48 0.44
138 INT148378 CP Positive_regulation of NOTCH1 1 0.11 0.64 0.44
139 INT148380 PDP1 Positive_regulation of Positive_regulation of CP 1 0.12 0.64 0.44
140 INT104447 Ido1 Negative_regulation of Binding of Atp7b 1 0.00 0.68 0.43
141 INT264473 Il1a Positive_regulation of Mapk1 1 0.00 0 0.43
142 INT146276 Binding of P2RX4 and P2RX7 1 0.38 0.38 0.43
143 INT264476 Il1a Positive_regulation of Gene_expression of Mapk8 1 0.04 0 0.43
144 INT56577 Mt1a Positive_regulation of Localization of Gnrh1 1 0.04 0 0.43
145 INT302829 Mapkapk5 Positive_regulation of Trp53 1 0.07 0.81 0.43
146 INT264471 Il1a Positive_regulation of Gene_expression of Mapk1 1 0.01 0 0.43
147 INT264475 Il1a Positive_regulation of Mapk8 1 0.04 0 0.43
148 INT169859 P2rx7 Regulation of Gene_expression of Grin1 1 0.17 0 0.43
149 INT264479 Il1a Positive_regulation of Gene_expression of Mapk14 1 0.02 0 0.43
150 INT198536 Cox11 Negative_regulation of HK1 1 0.22 0.08 0.41
151 INT159438 seb Positive_regulation of Gene_expression of Il1a 1 0.02 0 0.41
152 INT231303 Binding of Prnp and Helt 1 0.02 3.23 0.41
153 INT159439 sea Positive_regulation of Gene_expression of Il1a 1 0.07 0 0.41
154 INT19298 ANG Regulation of OXT 1 0.07 0 0.41
155 INT231304 Prnp Negative_regulation of Grin2d 2 0.38 0.5 0.4
156 INT100598 PRNP Positive_regulation of Gene_expression of IL6 1 0.40 0.23 0.4
157 INT46225 Binding of ALB and POMC 1 0.36 0 0.4
158 INT158104 Binding of Trpv1 and P2rx2 1 0.03 0.27 0.4
159 INT222418 Tlr4 Positive_regulation of Gene_expression of Il1a 1 0.00 0.31 0.39
160 INT288700 Binding of Cp and Tfrc 1 0.40 0 0.39
161 INT34856 Hpd Negative_regulation of Dbh 1 0.00 0 0.39
162 INT200096 Negative_regulation of Il1a Negative_regulation of Gene_expression of Ptgs2 1 0.00 1.45 0.39
163 INT10825 Binding of PDYN and Tyr 1 0.01 0 0.39
164 INT43956 GCG Regulation of ALB 1 0.16 0.15 0.38
165 INT250956 Positive_regulation of Binding of HLA-B and SOD1 1 0.07 0.38 0.38
166 INT264482 Il1a Positive_regulation of Phosphorylation of Mapk14 1 0.02 0 0.37
167 INT264481 Il1a Positive_regulation of Mapk14 1 0.02 0 0.37
168 INT264480 Il1a Positive_regulation of Phosphorylation of Mapk8 1 0.04 0 0.37
169 INT35685 TYR Regulation of Oxt 1 0.14 0.32 0.36
170 INT21945 Negative_regulation of Il1a Negative_regulation of LH 1 0.18 0 0.36
171 INT137625 Ntf3 Positive_regulation of Atp7b 1 0.04 0 0.36
172 INT19476 Binding of IL1A and Il6 1 0.00 2.19 0.36
173 INT19477 Binding of IL1A and Csf2 1 0.00 2.19 0.36
174 INT99171 Negative_regulation of Pomc Positive_regulation of Tyr 1 0.22 0.08 0.35
175 INT21946 Il1a Negative_regulation of LH 1 0.18 0 0.35
176 INT242363 Binding of Il1a and Il1rn 1 0.05 0.19 0.35
177 INT205704 P2rx7 Regulation of Localization of Il18 1 0.09 0.67 0.35
178 INT239398 Atp7b Regulation of OAP 1 0.03 1.1 0.35
179 INT164904 Binding of IL1A and IL33 1 0.39 0.19 0.35
180 INT310765 Binding of Pam and Tlr2 1 0.01 0.57 0.35
181 INT258762 Binding of Dbh and ADHD1 1 0.08 1.61 0.34
182 INT113476 IL1A Positive_regulation of Localization of MMP14 1 0.10 0.22 0.34
183 INT97357 IL1A Positive_regulation of Transcription of Timp1 1 0.06 0.47 0.34
184 INT323352 Binding of F8 and VWF 5 0.08 2.22 0.33
185 INT205713 Positive_regulation of P2rx7 Positive_regulation of Gene_expression of IL8 1 0.03 0.77 0.33
186 INT217025 P2rx7 Regulation of Gene_expression of Ik 1 0.00 0.25 0.33
187 INT285566 F8 Negative_regulation of IL2 1 0.00 0.62 0.33
188 INT14062 Binding of POMC and RNPEP 1 0.01 0 0.33
189 INT217024 Regulation of P2rx7 Regulation of Gene_expression of Ik 1 0.00 0.25 0.33
190 INT205703 P2rx7 Regulation of Positive_regulation of Casp1 1 0.11 0.66 0.33
191 INT205711 P2rx7 Regulation of Localization of IL8 1 0.02 0.92 0.33
192 INT92870 SON Regulation of IL1A 1 0.01 0.31 0.32
193 INT78063 Il1a Positive_regulation of Il1b 1 0.02 0.07 0.32
194 INT203089 Binding of Il1a and Traf6 1 0.04 0.66 0.32
195 INT91814 Binding of TNF and TP53 1 0.14 2.2 0.32
196 INT195665 APC Negative_regulation of F8 1 0.04 1.53 0.32
197 INT203085 Positive_regulation of Binding of Il1a and Myd88 1 0.07 0.65 0.32
198 INT203086 Positive_regulation of Binding of Il1a and Traf6 1 0.06 0.67 0.32
199 INT190806 Ubd Regulation of Abp1 1 0.20 0.82 0.32
200 INT21947 Il1a Positive_regulation of Localization of Pomc 1 0.48 0 0.32

Single Events

The table below shows the top 100 pain related interactions that have been reported for copper ion binding. They are ordered first by their pain relevance and then by number of times they were reported in copper ion binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT5969 Gene_expression of Il1a 221 0.75 96.31 71.38
2 INT546 Binding of ALB 311 0.48 85.98 60.14
3 INT62960 Gene_expression of P2rx2 149 0.77 58.31 59.16
4 INT117598 Regulation of ACR 118 0.26 41.25 48.01
5 INT3758 Gene_expression of ALB 326 0.78 184.65 38.75
6 INT163134 Gene_expression of ACR 78 0.65 30.39 38.48
7 INT49519 Gene_expression of P2rx7 84 0.76 36.88 34.69
8 INT12161 Positive_regulation of P2rx2 70 0.69 34.22 34.4
9 INT28361 Gene_expression of TP53 443 0.78 384.86 28.8
10 INT1166 Negative_regulation of Dbh 56 0.59 12.54 28.26
11 INT3760 Positive_regulation of ALB 142 0.70 87.46 26.7
12 INT5966 Localization of Il1a 50 0.78 22.91 26.54
13 INT86789 Gene_expression of P2rx4 46 0.77 30.66 25.68
14 INT11746 Positive_regulation of Il1a 65 0.63 42.94 23.54
15 INT102112 Gene_expression of Prnp 440 0.78 209.32 22.5
16 INT88327 Gene_expression of P2rx7 109 0.77 48.86 22.41
17 INT3382 Positive_regulation of Dbh 33 0.70 11.64 21.67
18 INT112427 Positive_regulation of P2rx4 27 0.68 26.29 21.31
19 INT14436 Gene_expression of Dbh 42 0.72 9.9 19.85
20 INT23787 Positive_regulation of P2rx7 36 0.68 23.54 19.45
21 INT16445 Gene_expression of IL1A 60 0.78 44.46 19.19
22 INT2960 Regulation of Dbh 32 0.47 10.32 18.94
23 INT3952 Negative_regulation of ALB 116 0.59 72.18 18.35
24 INT5967 Negative_regulation of Il1a 51 0.57 27.09 18.24
25 INT65856 Positive_regulation of TP53 138 0.67 112.65 16.71
26 INT2432 Positive_regulation of Cp 41 0.67 31.1 16.68
27 INT93361 Gene_expression of Trp53 208 0.78 175.35 16.65
28 INT32648 Gene_expression of Tyrp1 80 0.66 17.9 16.59
29 INT4073 Localization of Dbh 28 0.81 6.06 16.37
30 INT80972 Gene_expression of Tp53 104 0.78 102.74 16.02
31 INT91285 Negative_regulation of P2rx2 29 0.57 12.74 15.48
32 INT92839 Regulation of P2rx2 36 0.45 13.19 15.38
33 INT2383 Positive_regulation of CP 33 0.67 25.41 15.38
34 INT18773 Localization of ALB 117 0.80 69.18 13.8
35 INT121241 Positive_regulation of P2rx7 65 0.69 40.94 13.59
36 INT69569 Positive_regulation of Prnp 175 0.70 96.31 13.34
37 INT78234 Positive_regulation of Gene_expression of P2rx2 18 0.69 12.86 12.75
38 INT195226 Positive_regulation of ACR 23 0.26 7.85 12.62
39 INT31990 Positive_regulation of SOD1 124 0.69 67.79 12.52
40 INT11897 Gene_expression of Atp7b 25 0.13 7.85 12.5
41 INT14510 Gene_expression of SOD1 208 0.76 88.56 12.4
42 INT60461 Positive_regulation of Gene_expression of Il1a 40 0.61 17.23 12.35
43 INT222660 Phosphorylation of Tyr 2 0.06 5.31 12.33
44 INT90673 Gene_expression of LOX 66 0.65 69.71 12.18
45 INT122053 Positive_regulation of P2rx4 16 0.69 13.02 11.98
46 INT39587 Gene_expression of CP 42 0.65 31.48 11.87
47 INT19527 Negative_regulation of Gene_expression of Il1a 26 0.51 15.4 11.58
48 INT2260 Gene_expression of Tyr 30 0.49 7.05 11.31
49 INT85631 Positive_regulation of Tyrp1 40 0.64 18.73 10.84
50 INT27687 Regulation of Cp 20 0.53 9.75 10.8
51 INT94004 Negative_regulation of Lox 31 0.59 13.76 10.45
52 INT98329 Gene_expression of P2RX4 23 0.75 13.13 10.25
53 INT73427 Localization of P2rx7 24 0.79 8.65 9.87
54 INT29740 Gene_expression of ANG 55 0.78 24.53 9.86
55 INT169997 Positive_regulation of Gene_expression of Tp53 37 0.70 47.3 9.85
56 INT112428 Positive_regulation of Gene_expression of P2rx4 12 0.68 12.67 9.57
57 INT105304 Negative_regulation of Gene_expression of P2rx2 11 0.28 11.07 9.53
58 INT116705 Positive_regulation of Positive_regulation of P2rx2 13 0.49 9.44 9.47
59 INT168991 Negative_regulation of P2rx4 9 0.43 12.77 9.39
60 INT46273 Gene_expression of PRNP 103 0.78 110.34 9.25
61 INT860 Regulation of ALB 48 0.60 25.11 8.95
62 INT38173 Gene_expression of Ang 40 0.75 32.63 8.86
63 INT43811 Positive_regulation of Tyr 14 0.45 2.52 8.86
64 INT13010 Gene_expression of TYR 38 0.65 14.81 8.84
65 INT15768 Gene_expression of Il1a 20 0.71 9.31 8.78
66 INT90674 Negative_regulation of LOX 56 0.57 38.01 8.58
67 INT2921 Positive_regulation of F8 53 0.59 41.56 8.56
68 INT48257 Negative_regulation of P2rx7 18 0.41 7.82 8.42
69 INT2512 Negative_regulation of Cp 27 0.51 10.15 8.37
70 INT18185 Gene_expression of Tyr 32 0.76 12.52 8.17
71 INT136177 Gene_expression of P2rx4 8 0.75 6.74 8.05
72 INT5401 Gene_expression of DBH 17 0.78 1.92 8.01
73 INT67037 Gene_expression of Sod1 121 0.78 59.32 7.99
74 INT5481 Binding of TYR 26 0.47 1.3 7.95
75 INT12010 Gene_expression of Cp 38 0.65 20.55 7.84
76 INT47546 Binding of Dbh 11 0.44 5.69 7.84
77 INT19475 Positive_regulation of IL1A 20 0.67 17.99 7.57
78 INT57748 Positive_regulation of Gene_expression of TP53 85 0.69 79.55 7.49
79 INT5308 Regulation of Il1a 17 0.44 10.8 7.31
80 INT97055 Positive_regulation of Gene_expression of Trp53 51 0.70 45.7 7.25
81 INT55957 Positive_regulation of PRNP 57 0.67 37.87 7.11
82 INT21938 Positive_regulation of Atp7b 26 0.10 11.33 7.1
83 INT27916 Gene_expression of Mt1a 6 0.47 4.4 7.04
84 INT47540 Binding of Cp 20 0.41 15.54 7.01
85 INT14903 Negative_regulation of SOD1 81 0.57 42.02 6.91
86 INT3757 Positive_regulation of Gene_expression of ALB 45 0.69 23.73 6.85
87 INT120261 Binding of P2rx2 19 0.28 5.8 6.72
88 INT72532 Regulation of Gene_expression of Il1a 13 0.54 4.91 6.71
89 INT112430 Negative_regulation of P2rx4 9 0.57 8.4 6.63
90 INT3309 Binding of CP 25 0.47 17.87 6.62
91 INT23034 Positive_regulation of Il1a 15 0.70 8.75 6.29
92 INT88326 Negative_regulation of P2rx7 16 0.58 8.77 6.25
93 INT93359 Positive_regulation of Trp53 90 0.70 69.77 6.24
94 INT94608 Regulation of P2rx7 19 0.23 8.06 6.19
95 INT68882 Binding of P2rx7 16 0.23 4.33 6.17
96 INT11896 Negative_regulation of Atp7b 15 0.11 6.01 6.09
97 INT35780 Positive_regulation of Mt1a 9 0.55 4.9 6.08
98 INT49027 Gene_expression of TYRP1 35 0.75 9.81 6.06
99 INT103918 Phosphorylation of Tyr 12 0.47 10.12 5.96
100 INT112545 Phosphorylation of TP53 28 0.80 14.13 5.93
101 INT8157 Binding of Tyr 14 0.09 0.64 5.89
102 INT49025 Positive_regulation of TYR 14 0.69 7.15 5.84
103 INT65262 Gene_expression of Lox 47 0.74 36.59 5.65
104 INT58468 Negative_regulation of Gene_expression of IL1A 10 0.58 9.39 5.57
105 INT81326 Positive_regulation of Gene_expression of Ang 17 0.67 18.5 5.46
106 INT133638 Gene_expression of Dbh 9 0.78 1.23 5.46
107 INT69572 Localization of Prnp 96 0.81 38.11 5.45
108 INT145680 Regulation of P2rx7 22 0.61 11.92 5.42
109 INT91754 Gene_expression of Cp 42 0.77 21.97 5.38
110 INT266746 Binding of ACR 8 0.23 3.44 5.26
111 INT215594 Negative_regulation of Gene_expression of P2rx4 7 0.48 6.46 5.22
112 INT105306 Regulation of Gene_expression of P2rx2 7 0.21 6.92 5.22
113 INT60585 Regulation of TP53 59 0.59 54.55 5.21
114 INT89142 Gene_expression of Lox 28 0.67 15.36 5.2
115 INT58338 Negative_regulation of Localization of Il1a 8 0.25 3.13 5.18
116 INT2919 Negative_regulation of F8 47 0.59 23.48 5.1
117 INT145681 Regulation of P2rx4 4 0.61 3.41 5.09
118 INT10889 Gene_expression of F8 60 0.78 41.36 5.06
119 INT68591 Regulation of TYRP1 14 0.44 3.93 5.05
120 INT69310 Negative_regulation of IL1A 10 0.43 7.83 5.05
121 INT30738 Negative_regulation of Gene_expression of ALB 32 0.59 19.01 5.04
122 INT131152 Gene_expression of Cr1l 17 0.75 10.83 4.88
123 INT28176 Localization of Cp 17 0.73 14.3 4.86
124 INT104760 Localization of MT1A 13 0.44 1.5 4.85
125 INT102254 Positive_regulation of Gene_expression of Prnp 72 0.70 38.11 4.81
126 INT148649 Transcription of P2rx2 8 0.43 8.11 4.79
127 INT137332 Positive_regulation of Gene_expression of Sod1 41 0.70 19.8 4.69
128 INT109972 Phosphorylation of Trp53 13 0.80 6.15 4.68
129 INT20196 Negative_regulation of Gene_expression of Atp7b 8 0.07 2.49 4.63
130 INT62684 Negative_regulation of TP53 66 0.58 66.09 4.62
131 INT76884 Positive_regulation of Cp 22 0.69 12.84 4.6
132 INT158603 Positive_regulation of Gene_expression of P2RX4 7 0.55 5.85 4.56
133 INT36767 Localization of Atp7b 11 0.20 4.13 4.5
134 INT50309 Binding of Il1a 22 0.40 5.4 4.49
135 INT59083 Positive_regulation of Gene_expression of IL1A 11 0.70 9.09 4.48
136 INT57749 Negative_regulation of Gene_expression of TP53 39 0.56 36.79 4.45
137 INT69570 Binding of Prnp 75 0.48 44.26 4.37
138 INT185484 Positive_regulation of Gene_expression of P2rx7 8 0.31 7.44 4.28
139 INT136179 Positive_regulation of P2RX4 9 0.67 7.06 4.27
140 INT32446 Localization of Tyr 11 0.68 1.31 4.25
141 INT23035 Regulation of Il1a 6 0.60 5.69 4.25
142 INT15462 Negative_regulation of Il1a 4 0.59 4.68 4.17
143 INT11872 Protein_catabolism of Rnpep 6 0.87 0 4
144 INT144830 Positive_regulation of Gene_expression of P2rx7 22 0.68 9.78 3.92
145 INT44323 Positive_regulation of F8 32 0.60 24.88 3.89
146 INT19189 Localization of IL1A 14 0.78 9.02 3.78
147 INT75661 Regulation of CP 12 0.39 5.17 3.75
148 INT142501 Transcription of Tyrp1 4 0.18 2.09 3.71
149 INT71602 Negative_regulation of Trp53 84 0.59 67.77 3.68
150 INT31528 Regulation of TYR 6 0.44 0.83 3.63
151 INT215163 Phosphorylation of P2rx2 19 0.60 1.43 3.62
152 INT817 Negative_regulation of Abp1 15 0.49 4.25 3.56
153 INT119412 Gene_expression of Snca 15 0.66 11.27 3.39
154 INT28390 Negative_regulation of Mt1a 4 0.36 1.13 3.39
155 INT5400 Positive_regulation of DBH 6 0.70 2.02 3.38
156 INT18073 Positive_regulation of TYRP1 11 0.67 1.98 3.36
157 INT110245 Gene_expression of SNCA 11 0.77 8.29 3.36
158 INT111369 Transcription of Mt1a 4 0.68 1.01 3.35
159 INT59447 Negative_regulation of Tyr 12 0.56 4.57 3.32
160 INT129441 Regulation of Gene_expression of P2rx7 8 0.24 4.29 3.32
161 INT102255 Regulation of Prnp 35 0.62 18.97 3.25
162 INT28583 Positive_regulation of Gene_expression of Atp7b 4 0.06 0.34 3.24
163 INT20006 Gene_expression of MT1F 27 0.68 19.55 3.18
164 INT154233 Negative_regulation of Lox 32 0.56 38.89 3.17
165 INT15253 Binding of DBH 7 0.36 3.21 3.17
166 INT144828 Binding of P2rx7 19 0.47 7.84 3.16
167 INT81830 Localization of P2rx2 14 0.73 5.42 3.16
168 INT54619 Negative_regulation of Positive_regulation of Il1a 6 0.42 5.68 3.12
169 INT46291 Negative_regulation of Dbh 6 0.56 0.91 3.06
170 INT211192 Localization of ACR 8 0.73 3.04 3.03
171 INT8103 Binding of TP53 46 0.44 40.2 2.96
172 INT37435 Negative_regulation of Tyr 6 0.14 0.96 2.94
173 INT112429 Negative_regulation of Positive_regulation of P2rx4 4 0.57 4.03 2.94
174 INT37734 Positive_regulation of Ang 18 0.46 9.17 2.87
175 INT266745 Regulation of Gene_expression of ACR 6 0.10 1.53 2.87
176 INT28376 Regulation of Localization of Dbh 1 0.31 0 2.87
177 INT112431 Positive_regulation of Positive_regulation of P2rx4 2 0.49 3.52 2.81
178 INT16447 Binding of IL1A 10 0.45 4.01 2.78
179 INT14106 Positive_regulation of Abp1 4 0.51 3.85 2.78
180 INT32787 Positive_regulation of Gene_expression of Tyr 5 0.38 0.37 2.77
181 INT49020 Negative_regulation of TYR 11 0.58 1.97 2.68
182 INT109969 Positive_regulation of Phosphorylation of Trp53 1 0.45 2.18 2.66
183 INT83073 Negative_regulation of Tyrp1 10 0.23 4.4 2.65
184 INT5432 Regulation of Atp7b 7 0.36 0.87 2.65
185 INT122054 Positive_regulation of Positive_regulation of P2rx4 3 0.49 2.85 2.65
186 INT136176 Positive_regulation of Gene_expression of P2rx4 5 0.60 3.18 2.64
187 INT2958 Transcription of Dbh 4 0.71 2.57 2.64
188 INT91899 Binding of Sod1 17 0.47 11.56 2.63
189 INT102253 Negative_regulation of Prnp 75 0.59 24.23 2.62
190 INT107216 Negative_regulation of Gene_expression of P2rx7 10 0.56 3.39 2.61
191 INT12051 Negative_regulation of Rnpep 7 0.36 0.42 2.59
192 INT31989 Binding of SOD1 43 0.47 19.38 2.55
193 INT30040 Negative_regulation of TYRP1 11 0.51 2.72 2.54
194 INT63238 Gene_expression of Mt1 27 0.65 10.86 2.53
195 INT109968 Positive_regulation of Positive_regulation of Trp53 6 0.47 3.57 2.51
196 INT2695 Regulation of DBH 5 0.45 1.09 2.48
197 INT9455 Negative_regulation of Rnpep 5 0.31 0.52 2.47
198 INT135040 Regulation of Gene_expression of Prnp 30 0.62 10.52 2.45
199 INT49984 Localization of Il1a 5 0.77 3.61 2.42
200 INT37341 Regulation of Tyrp1 4 0.29 4.53 2.42
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