GO:0005528

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Name FK506 binding
Categary Function
Go Slim No
Go Link GO:0005528
Unique Molecular Interactions 72
Total Molecular Interactions 84
Total Single Events 219
Pain Genes Associated 10

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for FK506 binding. They are ordered first by their pain relevance and then by number of times they were reported for FK506 binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT228680 Fkbp1a Negative_regulation of Trib3 1 0.01 0.56 1.18
2 INT151807 Binding of NFATC1 and OPRM1 1 0.19 0 0.79
3 INT151808 NFATC1 Positive_regulation of Positive_regulation of OPRM1 1 0.20 0 0.76
4 INT335291 SLC15A4 Negative_regulation of NFATC1 1 0.01 0.45 0.51
5 INT326303 Binding of CRP and FKBP4 1 0.15 1.22 0.41
6 INT304340 FKBP5 Regulation of NR3C1 1 0.05 0.71 0.37
7 INT141046 Binding of NFATC1 and ZNF404 1 0.01 0 0.24
8 INT141045 ZNF404 Negative_regulation of Transcription of NFATC1 1 0.01 0 0.24
9 INT141048 ZNF404 Negative_regulation of Binding of NFATC1 1 0.01 0 0.24
10 INT141041 ZNF404 Negative_regulation of NFATC1 1 0.01 0 0.23
11 INT56010 Binding of FN1 and FKBPL 1 0.00 0.54 0.15
12 INT207776 Binding of FKBP1A and RYR1 1 0.05 0.59 0.12
13 INT293360 Binding of CSH1 and FKBP1A 1 0.00 0.14 0.05
14 INT207760 Fkbp1a Regulation of MSMB 1 0.12 0.69 0.04
15 INT226530 Binding of NFATC1 and Nfatc1 1 0.06 0.08 0.03
16 INT293358 Binding of FKBP1A and CABIN1 1 0.00 0.07 0.03
17 INT340214 BGLAP Regulation of Gene_expression of NFATC1 1 0.02 0.76 0
18 INT265231 Binding of FKBP1A and TGFBR1 1 0.11 0.35 0
19 INT293355 Binding of Fkbp1a and CABIN1 1 0.00 0.12 0
20 INT292147 Binding of HIVEP1 and NFATC1 1 0.00 0.31 0
21 INT273116 Binding of Fkbp1a and Mtor 1 0.37 0 0
22 INT340275 NFATC1 Positive_regulation of Binding of Ahr 1 0.10 0.51 0
23 INT292151 NFATC1 Positive_regulation of HIVEP1 1 0.00 0.31 0
24 INT340914 Binding of Hsp90aa1 and Fkbp6 1 0.12 0.26 0
25 INT292140 NFATC1 Regulation of FOSB 1 0.02 0.23 0
26 INT292144 Positive_regulation of NFATC1 Positive_regulation of HIVEP1 1 0.00 0.31 0
27 INT293354 Binding of CSH1 and Fkbp1a 1 0.00 0.12 0
28 INT265233 Binding of APC and FKBP1A 1 0.08 0.41 0
29 INT340919 Binding of Fkbp8 and Ptplad1 1 0.14 0.17 0
30 INT340913 Fkbp6 Negative_regulation of Binding of Hsp90aa1 1 0.14 0.26 0
31 INT292153 Positive_regulation of Binding of HIVEP1 and NFATC1 1 0.01 0.31 0
32 INT265234 Binding of FKBP1A and SGCG 1 0.03 0.35 0
33 INT293366 Binding of CABIN1 and Fkbp1a 1 0.00 0.05 0
34 INT265232 Regulation of Binding of APC and FKBP1A 1 0.08 0.41 0
35 INT271999 Binding of Fkbp1a and Positive_regulation of Negative_regulation of Mtor 1 0.00 0.18 0
36 INT190681 Binding of Bcl2 and Fkbp1a 1 0.01 0.46 0
37 INT271994 Binding of Fkbp1a and Mtor 1 0.00 0.22 0
38 INT294314 Binding of IL11 and NFATC1 1 0.06 0 0
39 INT340272 Tnfsf11 Positive_regulation of Gene_expression of NFATC1 1 0.09 0.56 0
40 INT351095 Binding of FKBP1A and RPS6KB1 1 0.24 0.36 0
41 INT351101 Negative_regulation of Binding of FKBP1A and RPS6KB1 1 0.27 0.36 0
42 INT260264 Binding of MTOR and FKBP7 1 0.26 0.87 0
43 INT351096 Binding of FKBP1A and MTOR 1 0.28 1.35 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for FK506 binding. They are ordered first by their pain relevance and then by number of times they were reported in FK506 binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT60575 Binding of Fkbp1a 9 0.26 2.09 4.46
2 INT112418 Gene_expression of FKBP5 3 0.43 1.97 1.62
3 INT112420 Negative_regulation of Gene_expression of FKBP5 1 0.16 0.85 1.42
4 INT141054 Binding of NFATC1 14 0.40 3.65 1.22
5 INT230251 Binding of FKBP1A 6 0.28 2.24 0.94
6 INT141058 Gene_expression of NFATC1 8 0.56 8.21 0.89
7 INT141057 Positive_regulation of NFATC1 5 0.57 1.95 0.74
8 INT157849 Negative_regulation of FKBP5 1 0.32 1.72 0.69
9 INT304344 Positive_regulation of FKBP5 1 0.41 1.36 0.64
10 INT157848 Regulation of FKBP5 1 0.34 1.74 0.53
11 INT141052 Transcription of NFATC1 5 0.44 1.34 0.49
12 INT279363 Binding of FKBP4 1 0.05 0.22 0.49
13 INT226449 Negative_regulation of NFATC1 4 0.25 1.28 0.41
14 INT141051 Phosphorylation of NFATC1 4 0.52 0.25 0.36
15 INT207064 Gene_expression of Fkbp1a 2 0.32 1.52 0.34
16 INT157850 Positive_regulation of Negative_regulation of FKBP5 1 0.37 0.87 0.34
17 INT304343 Positive_regulation of Positive_regulation of FKBP5 1 0.41 0.68 0.33
18 INT207065 Localization of Fkbp1a 1 0.36 0.82 0.33
19 INT141056 Negative_regulation of Binding of NFATC1 2 0.35 0 0.31
20 INT190676 Binding of Fkbp1a 15 0.36 3.11 0.28
21 INT202802 Regulation of Fkbp1a 4 0.26 0.96 0.28
22 INT164519 Gene_expression of FKBP1A 2 0.39 0.22 0.19
23 INT141055 Regulation of NFATC1 2 0.20 0.65 0.19
24 INT141050 Regulation of Positive_regulation of NFATC1 1 0.51 0 0.19
25 INT292224 Localization of NFATC1 3 0.15 0.45 0.13
26 INT293345 Negative_regulation of Binding of FKBP1A 1 0.02 0.19 0.13
27 INT56013 Binding of FKBPL 1 0.00 0.54 0.12
28 INT299319 Localization of FKBP1A 1 0.44 0 0.09
29 INT294324 Positive_regulation of Transcription of NFATC1 1 0.09 0 0.08
30 INT294351 Regulation of Transcription of NFATC1 1 0.08 0 0.08
31 INT294337 Positive_regulation of Localization of NFATC1 1 0.13 0 0.08
32 INT299313 Positive_regulation of Gene_expression of FKBP1A 1 0.29 0 0.05
33 INT226451 Positive_regulation of Gene_expression of NFATC1 1 0.37 2.45 0.04
34 INT294339 Negative_regulation of Gene_expression of NFATC1 3 0.25 1.49 0.03
35 INT294345 Negative_regulation of Positive_regulation of NFATC1 1 0.08 0 0.03
36 INT340871 Binding of Fkbp6 1 0.21 0.13 0
37 INT260277 Gene_expression of FKBP7 1 0.55 0.14 0
38 INT260283 Binding of FKBP7 1 0.34 0 0
39 INT340903 Gene_expression of Fkbp6 1 0.43 0.13 0
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