GO:0005540

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Name hyaluronic acid binding
Categary Function
Go Slim No
Go Link GO:0005540
Unique Molecular Interactions 111
Total Molecular Interactions 192
Total Single Events 1286
Pain Genes Associated 16

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for hyaluronic acid binding. They are ordered first by their pain relevance and then by number of times they were reported for hyaluronic acid binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT205152 Binding of CD44 and MMP9 23 0.35 17.13 1.85
2 INT179444 Hmmr Negative_regulation of Gpr156 1 0.03 0 1.79
3 INT33757 Hmmr Positive_regulation of Npr1 1 0.01 0 1.59
4 INT33759 Hmmr Positive_regulation of Akr1d1 1 0.00 0 1.58
5 INT24796 ACE Positive_regulation of Localization of HMMR 1 0.00 0.58 1.16
6 INT203103 ACAN Negative_regulation of Gene_expression of IL10 1 0.02 1.31 1.12
7 INT296298 Grin2b Regulation of Negative_regulation of Hmmr 1 0.03 0.29 0.71
8 INT296288 Grin2a Regulation of Negative_regulation of Hmmr 1 0.03 0.29 0.71
9 INT60051 Ptger1 Positive_regulation of STAB2 1 0.00 0.77 0.68
10 INT114505 Negative_regulation of Hmmr Positive_regulation of Casp3 1 0.01 0.72 0.6
11 INT114506 Hmmr Positive_regulation of Casp3 1 0.01 0.72 0.6
12 INT281087 Binding of Gria1 and Hmmr 1 0.04 0 0.55
13 INT91428 CD44 Positive_regulation of Binding of MMRN1 1 0.24 0.85 0.55
14 INT187100 Binding of Cd4 and Cd44 1 0.02 1.09 0.47
15 INT335594 Myo5a Regulation of Hmmr 1 0.00 0.39 0.45
16 INT317636 Creb1 Positive_regulation of Phosphorylation of Hmmr 1 0.04 0.55 0.45
17 INT215564 Hmmr Negative_regulation of P2ry2 1 0.00 0 0.44
18 INT148548 Cd44 Positive_regulation of Regulation of NPEPPS 1 0.00 0.29 0.42
19 INT148547 Cd44 Positive_regulation of NPEPPS 1 0.00 0.29 0.41
20 INT166792 Binding of CD44 and HRAS 3 0.12 1.49 0.37
21 INT77521 Hmmr Positive_regulation of Nfkbiz 1 0.04 0 0.37
22 INT133307 Binding of CD44 and SPP1 5 0.26 2.6 0.35
23 INT343931 Hapln1 Negative_regulation of Tlr4 1 0.12 0.42 0.25
24 INT123221 Binding of ADRA1D and TNFAIP6 1 0.03 0.76 0.25
25 INT205155 Negative_regulation of Binding of CD44 and MMP9 1 0.32 1.98 0.23
26 INT166791 CD44 Positive_regulation of Gene_expression of PTGER1 1 0.05 0.15 0.2
27 INT166787 CD44 Negative_regulation of Gene_expression of PTGER1 1 0.04 0.15 0.2
28 INT305001 Binding of ACAN and TNFAIP6 1 0.28 1.22 0.14
29 INT256320 Binding of CYP26A1 and Hapln1 1 0.01 1.27 0.14
30 INT208459 Galns Negative_regulation of Negative_regulation of BCAN 1 0.01 0.44 0.13
31 INT204899 Tlr4 Positive_regulation of Cd44 1 0.23 0.09 0.09
32 INT204885 Tlr4 Negative_regulation of Positive_regulation of Cd44 1 0.21 0.09 0.09
33 INT185980 Eclb Positive_regulation of Gene_expression of Bcan 1 0.01 0.17 0.09
34 INT204889 Tlr4 Negative_regulation of Cd44 1 0.10 0.09 0.09
35 INT25269 Hmmr Negative_regulation of Npr1 1 0.01 0.63 0.08
36 INT340424 Hmmr Regulation of Cxcl2 1 0.01 1.12 0.08
37 INT340425 Hmmr Regulation of Ccl2 1 0.01 1.12 0.08
38 INT27290 Cytl1 Positive_regulation of CD44 1 0.00 0.99 0.08
39 INT340420 Hmmr Regulation of P2rx7 1 0.01 1.12 0.08
40 INT133306 Positive_regulation of Binding of CD44 and SPP1 1 0.16 0.83 0.07
41 INT205160 Binding of CD44 and MMP2 1 0.09 0.61 0.07
42 INT204998 Hmmr Positive_regulation of Eri1 1 0.00 0.58 0.06
43 INT204999 Hmmr Positive_regulation of Pink1 1 0.01 0.58 0.06
44 INT204992 Hmmr Positive_regulation of Hras1 1 0.00 0.58 0.06
45 INT220458 Binding of VCAN and SELP 1 0.01 1.15 0.05
46 INT352612 Trp53 Negative_regulation of Cd44 1 0.24 1.01 0.04
47 INT220457 Binding of VCAN and FN1 1 0.02 0.93 0.04
48 INT276381 Timp1 Positive_regulation of CD44 1 0.07 0.72 0.04
49 INT276376 Gtf3a Regulation of CD44 1 0.00 0.86 0.04
50 INT276385 Timp1 Regulation of CD44 1 0.04 0.87 0.04
51 INT267136 Binding of CD44 and FN1 2 0.04 0.56 0
52 INT176543 Binding of Cd44 and Spp1 2 0.31 0.57 0
53 INT325945 Binding of Cd44 and Ezr 1 0.25 0.39 0
54 INT170121 ITGAL Regulation of CD44 1 0.07 1.07 0
55 INT271646 VCAN Regulation of Gene_expression of FN1 1 0.06 0.15 0
56 INT220456 Binding of VCAN and BAG6 1 0.01 3.46 0
57 INT323806 NFAT5 Regulation of Transcription of ACAN 1 0.40 0.07 0
58 INT312225 Positive_regulation of INPP5K Positive_regulation of CD44 1 0.15 0.1 0
59 INT170118 PECAM1 Regulation of CD44 1 0.01 1.07 0
60 INT180857 TGFB1 Regulation of VCAN 1 0.04 0.69 0
61 INT199360 Igf2 Regulation of Gene_expression of Lyve1 1 0.30 1.13 0
62 INT271650 GFAP Regulation of Gene_expression of VCAN 1 0.23 0.15 0
63 INT170116 ITGAM Regulation of CD44 1 0.07 1.07 0
64 INT271644 VCAN Regulation of Gene_expression of CSPG4 1 0.38 0.15 0
65 INT312229 INPP5K Positive_regulation of CD44 1 0.15 0.1 0
66 INT271645 VCAN Regulation of CSPG4 1 0.38 0.15 0
67 INT220461 Binding of VCAN and EGFR 1 0.00 0.86 0
68 INT271649 VCAN Regulation of Gene_expression of GFAP 1 0.23 0.15 0
69 INT180844 TGFB1 Regulation of Gene_expression of VCAN 1 0.16 0.7 0
70 INT205156 CD44 Positive_regulation of MMP9 1 0.51 0.24 0
71 INT328775 Binding of Cd44 and Epcam 1 0.08 1.34 0
72 INT130851 Acan Positive_regulation of Gene_expression of Bgn 1 0.02 0.07 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for hyaluronic acid binding. They are ordered first by their pain relevance and then by number of times they were reported in hyaluronic acid binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT63361 Gene_expression of CD44 126 0.77 71.58 12.96
2 INT25057 Positive_regulation of Hmmr 14 0.28 5.09 9.63
3 INT25056 Regulation of Hmmr 6 0.37 2.19 4.54
4 INT67144 Gene_expression of Cd44 17 0.76 8.94 4.48
5 INT48411 Gene_expression of Cd44 35 0.77 27.05 4.29
6 INT26337 Negative_regulation of Hmmr 6 0.30 1.11 4.01
7 INT56893 Localization of Hmmr 3 0.13 0.24 3.69
8 INT88292 Positive_regulation of Transcription of Hmmr 6 0.06 1.87 3.66
9 INT88288 Transcription of Hmmr 6 0.09 1.86 3.65
10 INT173878 Gene_expression of ACAN 32 0.75 9.35 3.55
11 INT88289 Gene_expression of Hmmr 11 0.08 1.84 3.24
12 INT24797 Localization of HMMR 5 0.45 1.4 3.03
13 INT88287 Phosphorylation of Hmmr 6 0.10 0.99 2.9
14 INT88284 Positive_regulation of Phosphorylation of Hmmr 1 0.04 0.34 2.72
15 INT91429 Binding of CD44 34 0.41 17.67 2.51
16 INT185961 Gene_expression of Bcan 1 0.18 1.97 2.46
17 INT69945 Regulation of Hmmr 5 0.07 2.42 2.32
18 INT32046 Gene_expression of Hmmr 5 0.28 1.83 1.97
19 INT218826 Positive_regulation of Hmmr 4 0.06 3.87 1.9
20 INT91430 Positive_regulation of CD44 25 0.69 15.43 1.76
21 INT123223 Binding of TNFAIP6 5 0.35 3.36 1.65
22 INT126010 Positive_regulation of Positive_regulation of Hmmr 1 0.00 1.47 1.57
23 INT203116 Positive_regulation of ACAN 6 0.67 3.98 1.56
24 INT173716 Positive_regulation of Cd44 7 0.44 4.65 1.45
25 INT25544 Positive_regulation of Hapln1 3 0.12 8.58 1.44
26 INT123924 Positive_regulation of Gene_expression of Cd44 2 0.46 1.11 1.25
27 INT123224 Gene_expression of TNFAIP6 12 0.70 7.13 1.21
28 INT288313 Negative_regulation of Hmmr 3 0.04 0.43 1.14
29 INT41540 Negative_regulation of Localization of HMMR 3 0.27 0.47 1.14
30 INT91431 Positive_regulation of Gene_expression of CD44 18 0.69 9.25 1.12
31 INT135390 Binding of Cd44 3 0.45 1.91 1.09
32 INT63354 Negative_regulation of Gene_expression of CD44 4 0.50 4.76 1.01
33 INT173852 Protein_catabolism of ACAN 3 0.64 1.65 1.01
34 INT25546 Gene_expression of Hapln1 8 0.14 5.58 0.99
35 INT106386 Regulation of Gene_expression of CD44 8 0.27 3.66 0.96
36 INT135392 Localization of Cd44 1 0.75 1.74 0.93
37 INT199345 Gene_expression of Lyve1 11 0.50 8.44 0.89
38 INT77326 Regulation of Localization of Hmmr 1 0.05 0 0.89
39 INT109133 Gene_expression of VCAN 52 0.75 53.11 0.84
40 INT88283 Positive_regulation of Gene_expression of Hmmr 2 0.06 0.78 0.81
41 INT204842 Positive_regulation of Cd44 9 0.49 6.6 0.77
42 INT149048 Localization of Hmmr 3 0.13 3.2 0.77
43 INT107508 Phosphorylation of HMMR 1 0.03 0.09 0.76
44 INT168152 Binding of ACAN 3 0.36 0.88 0.73
45 INT240464 Regulation of Gene_expression of Hmmr 1 0.05 0.51 0.71
46 INT240465 Positive_regulation of Gene_expression of Hmmr 1 0.05 0.51 0.71
47 INT187096 Negative_regulation of Cd44 6 0.30 5.92 0.7
48 INT203115 Regulation of ACAN 2 0.60 1.07 0.69
49 INT187087 Binding of Cd44 5 0.47 2.79 0.66
50 INT280964 Transcription of ACAN 7 0.64 1.87 0.65
51 INT46198 Binding of Hapln1 5 0.31 2.14 0.63
52 INT63356 Regulation of CD44 6 0.23 6.29 0.61
53 INT203118 Positive_regulation of Gene_expression of ACAN 5 0.49 1.7 0.61
54 INT223857 Regulation of Gene_expression of Hmmr 1 0.03 0 0.61
55 INT288158 Negative_regulation of Gene_expression of Cd44 5 0.30 5.73 0.59
56 INT127888 Negative_regulation of HMMR 3 0.11 3.89 0.55
57 INT185963 Protein_catabolism of Bcan 1 0.15 0.19 0.52
58 INT71274 Gene_expression of Acan 3 0.12 0.99 0.5
59 INT106384 Negative_regulation of CD44 7 0.42 2.14 0.47
60 INT86727 Positive_regulation of Negative_regulation of Hmmr 1 0.00 0 0.47
61 INT317621 Phosphorylation of Hmmr 1 0.06 0.54 0.44
62 INT205169 Localization of CD44 7 0.64 2.3 0.41
63 INT185966 Localization of Bcan 1 0.16 0.51 0.41
64 INT224444 Positive_regulation of Lyve1 1 0.36 0.63 0.4
65 INT275316 Localization of ACAN 1 0.73 0.22 0.39
66 INT185962 Negative_regulation of Bcan 1 0.10 0.39 0.36
67 INT185977 Regulation of Gene_expression of Bcan 1 0.14 0.09 0.33
68 INT205172 Negative_regulation of Binding of CD44 1 0.36 1.97 0.31
69 INT189250 Positive_regulation of BCAN 1 0.29 1.66 0.31
70 INT185965 Regulation of Bcan 1 0.10 0.27 0.29
71 INT103070 Negative_regulation of Gene_expression of Cd44 1 0.38 0.43 0.29
72 INT71271 Positive_regulation of Acan 2 0.09 0.55 0.27
73 INT71275 Positive_regulation of Localization of Acan 1 0.05 0.48 0.27
74 INT272137 Positive_regulation of Hapln1 2 0.10 0.78 0.26
75 INT71272 Localization of Acan 1 0.08 0.48 0.26
76 INT281074 Negative_regulation of Gene_expression of Hmmr 1 0.04 0.06 0.26
77 INT46197 Gene_expression of Hapln1 2 0.53 0.54 0.25
78 INT185824 Negative_regulation of Negative_regulation of CD44 1 0.28 0.42 0.24
79 INT203080 Negative_regulation of Cd44 1 0.14 0.3 0.24
80 INT223562 Localization of Lyve1 1 0.60 1.63 0.23
81 INT185967 Positive_regulation of Bcan 1 0.11 0 0.22
82 INT149047 Regulation of Localization of Hmmr 1 0.05 0.68 0.22
83 INT48656 Positive_regulation of Gene_expression of Cd44 7 0.69 5.93 0.21
84 INT323808 Negative_regulation of Transcription of ACAN 1 0.38 0.42 0.21
85 INT323813 Negative_regulation of ACAN 1 0.38 0.42 0.21
86 INT323809 Positive_regulation of Transcription of ACAN 2 0.45 1 0.19
87 INT130849 Transcription of Acan 1 0.10 0.46 0.19
88 INT27355 Localization of STAB2 1 0.00 0.93 0.19
89 INT180885 Positive_regulation of Gene_expression of VCAN 10 0.35 12.52 0.18
90 INT246630 Positive_regulation of Positive_regulation of CD44 1 0.51 0.34 0.18
91 INT214464 Regulation of Gene_expression of Cd44 3 0.34 2.95 0.17
92 INT343929 Positive_regulation of Gene_expression of Hapln1 1 0.10 0.28 0.16
93 INT305013 Positive_regulation of Gene_expression of TNFAIP6 1 0.62 1.24 0.15
94 INT74687 Negative_regulation of STAB2 1 0.00 0.29 0.15
95 INT180894 Regulation of VCAN 4 0.37 4 0.14
96 INT220469 Binding of VCAN 1 0.06 6.24 0.13
97 INT180896 Regulation of Gene_expression of VCAN 1 0.16 1.73 0.12
98 INT305021 Positive_regulation of TNFAIP6 1 0.45 1.13 0.12
99 INT208450 Negative_regulation of BCAN 1 0.03 0.43 0.12
100 INT305012 Transcription of TNFAIP6 1 0.48 1.13 0.12
101 INT137676 Regulation of Phosphorylation of Hmmr 1 0.03 0 0.11
102 INT180895 Positive_regulation of VCAN 5 0.28 5.45 0.1
103 INT288160 Regulation of Cd44 1 0.42 0.67 0.1
104 INT25545 Localization of Hapln1 1 0.02 0.68 0.09
105 INT203611 Positive_regulation of Negative_regulation of CD44 1 0.24 0.31 0.09
106 INT256314 Regulation of Hapln1 1 0.05 0.45 0.08
107 INT245318 Regulation of Gene_expression of ACAN 2 0.55 0.31 0.07
108 INT272139 Regulation of Hapln1 1 0.02 0.54 0.07
109 INT67143 Binding of Acan 1 0.36 0 0.07
110 INT185976 Positive_regulation of Gene_expression of Bcan 1 0.11 0.17 0.06
111 INT117324 Localization of Hapln1 1 0.07 0 0.05
112 INT220470 Localization of VCAN 1 0.10 3.84 0.05
113 INT200859 Transcription of Cd44 2 0.41 0.71 0.04
114 INT272141 Negative_regulation of Hapln1 1 0.04 0.37 0.04
115 INT189246 Gene_expression of BCAN 1 0.32 1.05 0.03
116 INT204861 Localization of Cd44 1 0.46 0.06 0.03
117 INT213134 Negative_regulation of Hapln1 1 0.04 0.88 0.03
118 INT205162 Regulation of Binding of CD44 1 0.38 0.26 0.03
119 INT133317 Positive_regulation of Binding of CD44 6 0.55 6.28 0
120 INT220471 Negative_regulation of Gene_expression of VCAN 5 0.41 3.44 0
121 INT323818 Regulation of Transcription of ACAN 1 0.24 0.07 0
122 INT299521 Regulation of Cd44 1 0.12 0.36 0
123 INT205180 Regulation of Localization of CD44 1 0.38 0.22 0
124 INT319046 Gene_expression of HMMR 1 0.41 0.88 0
125 INT185975 Regulation of Transcription of Bcan 1 0.10 0 0
126 INT235270 Positive_regulation of Binding of Cd44 1 0.26 1.11 0
127 INT319047 Positive_regulation of Gene_expression of HMMR 1 0.31 0.88 0
128 INT118667 Transcription of VCAN 1 0.52 0.08 0
129 INT185960 Transcription of Bcan 1 0.16 0 0
130 INT271680 Negative_regulation of VCAN 1 0.41 0.42 0
131 INT298953 Positive_regulation of Gene_expression of Lyve1 1 0.03 0.77 0
132 INT205164 Negative_regulation of Localization of CD44 1 0.36 0.12 0
133 INT130844 Positive_regulation of Gene_expression of Acan 1 0.09 0 0
134 INT185958 Positive_regulation of Transcription of Bcan 1 0.11 0 0
135 INT323819 Regulation of Protein_catabolism of ACAN 1 0.24 0.23 0
136 INT187639 Localization of TNFAIP6 1 0.11 0.72 0
137 INT301984 Negative_regulation of Positive_regulation of Cd44 1 0.17 1.28 0
138 INT118665 Negative_regulation of Transcription of VCAN 1 0.42 0.08 0
139 INT130848 Positive_regulation of Transcription of Acan 1 0.09 0 0
140 INT220473 Positive_regulation of Binding of VCAN 1 0.07 1.28 0
141 INT345366 Binding of Lyve1 1 0.21 0.99 0
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