GO:0005542

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Name folic acid binding
Categary Function
Go Slim No
Go Link GO:0005542
Unique Molecular Interactions 39
Total Molecular Interactions 52
Total Single Events 408
Pain Genes Associated 11

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for folic acid binding. They are ordered first by their pain relevance and then by number of times they were reported for folic acid binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT91271 Mtr Regulation of Gene_expression of Il6 1 0.20 0 3.17
2 INT73116 TYMS Negative_regulation of DNMT3B 1 0.24 0 1.6
3 INT73115 TYMS Negative_regulation of Positive_regulation of DNMT3B 1 0.24 0 1.6
4 INT27425 Mtr Positive_regulation of Gene_expression of Il1f5 1 0.06 0 1.3
5 INT45891 Tyms Positive_regulation of Localization of Acot1 1 0.02 0 1.23
6 INT35399 Binding of Alox5 and Mthfs 1 0.01 0 1.14
7 INT107561 Mtr Positive_regulation of Localization of Il1b 1 0.04 0.09 1.09
8 INT107563 Penk Regulation of Mtr 1 0.00 0.1 1.04
9 INT107565 Hps4 Regulation of Mtr 1 0.00 0.1 1.04
10 INT25110 RYBP Negative_regulation of MTHFS 1 0.02 0 0.92
11 INT91273 Mtr Positive_regulation of Localization of Il6 1 0.17 0 0.88
12 INT84414 Folr2 Regulation of Binding of Oprd1 1 0.03 0.18 0.84
13 INT54669 Mtr Regulation of Gene_expression of Il1 1 0.02 0.2 0.77
14 INT54668 Mtr Regulation of Gene_expression of Il1f5 1 0.00 0.2 0.76
15 INT46657 Mtr Regulation of Gnrh1 1 0.01 0 0.71
16 INT46656 Mtr Regulation of Prl 1 0.05 0 0.7
17 INT38820 Binding of MTR and PDYN 1 0.03 0.19 0.65
18 INT27426 Mtr Positive_regulation of Localization of Il1f5 1 0.06 0 0.63
19 INT35397 Fnd3c2 Negative_regulation of Binding of Mthfs 1 0.00 0 0.58
20 INT50935 Mtr Regulation of Gene_expression of Il6 1 0.00 0 0.53
21 INT292631 FOLR1 Positive_regulation of Gene_expression of IL9 1 0.00 0.46 0.51
22 INT28863 Mtr Negative_regulation of Dhfr 1 0.04 0.87 0.45
23 INT13715 PDYN Positive_regulation of TYMS 1 0.27 0 0.39
24 INT16382 Binding of Grin1 and Gnmt 1 0.04 0.17 0.32
25 INT143628 MTHFS Positive_regulation of Gene_expression of MRXS5 1 0.01 0.55 0.23
26 INT50934 Mtr Positive_regulation of Gene_expression of Il6 1 0.00 0 0.2
27 INT66035 FOLR2 Negative_regulation of Il1a 1 0.00 0.56 0.18
28 INT66036 FOLR2 Negative_regulation of Tnf 1 0.00 0.56 0.18
29 INT66030 FOLR2 Negative_regulation of IL1B 1 0.00 0.56 0.18
30 INT66033 FOLR2 Negative_regulation of Tnf 1 0.00 0.56 0.18
31 INT292626 Gene_expression of IL9 Positive_regulation of FOLR1 1 0.00 0.25 0.11
32 INT245985 Binding of MTR and Mtrr 1 0.06 0.8 0.07
33 INT245986 MTR Regulation of Mthfr 1 0.07 0.18 0.05
34 INT245966 TCN1 Regulation of MTR 1 0.02 0.18 0.05
35 INT245967 Negative_regulation of TCN1 Regulation of MTR 1 0.02 0.18 0.05
36 INT245987 Binding of MTR and Mthfr 1 0.11 0.48 0.03
37 INT66034 FOLR2 Negative_regulation of Gene_expression of Il1a 1 0.00 0.18 0
38 INT147144 E2F1 Positive_regulation of Transcription of TYMS 1 0.26 0 0
39 INT234144 Fig4 Negative_regulation of Transcription of Tyms 1 0.05 0.18 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for folic acid binding. They are ordered first by their pain relevance and then by number of times they were reported in folic acid binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT5298 Negative_regulation of MTHFS 70 0.57 27.07 28.11
2 INT1672 Gene_expression of Mtr 18 0.67 3.39 13.32
3 INT20131 Negative_regulation of Mthfs 18 0.57 7.93 10.54
4 INT9802 Positive_regulation of Mtr 9 0.60 3.69 7.43
5 INT46518 Localization of Mtr 12 0.65 1.31 6.55
6 INT10006 Regulation of Mtr 9 0.23 3.56 5.42
7 INT12250 Negative_regulation of Mtr 19 0.50 6.9 5.35
8 INT9803 Positive_regulation of Gene_expression of Mtr 3 0.60 1.45 4.36
9 INT17444 Gene_expression of MTHFS 14 0.66 5.17 3.85
10 INT24751 Gene_expression of Mtr 8 0.36 1.34 3.34
11 INT52911 Gene_expression of Tyms 10 0.42 2.24 2.66
12 INT3123 Localization of Tyms 6 0.78 0.85 2.6
13 INT213681 Gene_expression of TYMS 9 0.33 8.96 2.45
14 INT213676 Negative_regulation of Gene_expression of TYMS 2 0.08 1.95 1.83
15 INT174240 Negative_regulation of TYMS 12 0.57 6.35 1.82
16 INT25582 Regulation of Mtr 2 0.03 0.4 1.76
17 INT29836 Regulation of MTHFS 6 0.33 1.43 1.67
18 INT47446 Regulation of Localization of Mtr 1 0.05 0.07 1.42
19 INT10032 Localization of MTHFS 4 0.17 3.11 1.37
20 INT9217 Negative_regulation of MTR 17 0.58 1.13 1.32
21 INT2595 Binding of Mtr 1 0.29 0 1.24
22 INT52912 Binding of Tyms 5 0.46 0.78 1.16
23 INT47131 Negative_regulation of Localization of Mtr 1 0.41 0 1.06
24 INT157361 Localization of MTR 2 0.31 1.4 1.05
25 INT24750 Negative_regulation of Mtr 1 0.22 0.06 1.04
26 INT35396 Binding of Mthfs 3 0.07 1.1 1.02
27 INT45917 Regulation of Negative_regulation of MTHFS 1 0.44 0 1.02
28 INT103240 Negative_regulation of Tyms 4 0.57 1.7 0.99
29 INT34923 Positive_regulation of MTHFS 2 0.49 1.4 0.9
30 INT34863 Positive_regulation of Negative_regulation of MTHFS 1 0.49 1.02 0.86
31 INT292650 Positive_regulation of FOLR1 1 0.01 0.95 0.82
32 INT275575 Gene_expression of FOLR1 12 0.66 2.81 0.8
33 INT22378 Negative_regulation of Negative_regulation of MTHFS 3 0.57 0.18 0.74
34 INT24584 Positive_regulation of MTR 4 0.44 0.07 0.7
35 INT10007 Regulation of Gene_expression of Mtr 2 0.23 1.17 0.61
36 INT14109 Positive_regulation of Mtr 1 0.03 0.49 0.6
37 INT13717 Positive_regulation of TYMS 3 0.40 1.64 0.49
38 INT97316 Positive_regulation of Gene_expression of Mthfs 1 0.04 0 0.43
39 INT97317 Gene_expression of Mthfs 1 0.06 0 0.42
40 INT24583 Protein_catabolism of MTR 1 0.57 0 0.42
41 INT44273 Binding of MTHFS 3 0.29 0.81 0.41
42 INT54952 Binding of Mtr 1 0.03 0.58 0.37
43 INT26194 Regulation of MTR 1 0.19 1.1 0.33
44 INT16380 Positive_regulation of Gnmt 1 0.05 0.25 0.33
45 INT166893 Negative_regulation of Gene_expression of Mtr 1 0.03 0.57 0.33
46 INT105447 Positive_regulation of Gene_expression of MTHFS 2 0.32 0.78 0.31
47 INT282213 Negative_regulation of Regulation of Mtr 1 0.01 0.82 0.27
48 INT44275 Negative_regulation of Positive_regulation of MTHFS 1 0.25 0.15 0.25
49 INT67859 Negative_regulation of Gene_expression of MTHFS 1 0.07 0.33 0.24
50 INT237464 Positive_regulation of Negative_regulation of TYMS 2 0.20 0.53 0.23
51 INT66031 Regulation of FOLR2 1 0.00 0.37 0.23
52 INT70913 Gene_expression of MTR 2 0.12 0.44 0.21
53 INT66032 Negative_regulation of FOLR2 1 0.00 0.55 0.18
54 INT44276 Negative_regulation of Regulation of MTHFS 1 0.16 0.08 0.18
55 INT106988 Negative_regulation of Binding of Mthfs 1 0.04 0.25 0.17
56 INT223333 Negative_regulation of Gene_expression of MTR 1 0.07 0.16 0.16
57 INT292659 Positive_regulation of Gene_expression of FOLR1 2 0.47 1.59 0.14
58 INT55773 Binding of MTR 2 0.30 0.74 0.14
59 INT103257 Regulation of Folr2 1 0.09 0.17 0.13
60 INT279806 Regulation of TYMS 2 0.05 1 0.12
61 INT113808 Positive_regulation of Mthfs 1 0.01 0.81 0.12
62 INT292651 Localization of FOLR1 1 0.01 0.18 0.09
63 INT12251 Regulation of Negative_regulation of Mtr 1 0.19 0 0.09
64 INT106363 Positive_regulation of Tyms 2 0.02 0.66 0.08
65 INT162255 Positive_regulation of Binding of Tyms 2 0.45 0.64 0.07
66 INT55772 Negative_regulation of Negative_regulation of MTR 1 0.41 0 0.07
67 INT147148 Transcription of TYMS 2 0.30 0.5 0.06
68 INT237463 Regulation of Gene_expression of TYMS 1 0.12 0.51 0.06
69 INT234136 Transcription of Tyms 1 0.48 0.77 0.06
70 INT237466 Regulation of Transcription of TYMS 1 0.26 0.5 0.06
71 INT234129 Positive_regulation of Transcription of Tyms 1 0.35 0.12 0.06
72 INT288754 Negative_regulation of Positive_regulation of Mtr 1 0.11 0.1 0.05
73 INT77507 Regulation of Mthfs 1 0.03 0.71 0.05
74 INT288233 Localization of TYMS 2 0.22 2.17 0.04
75 INT288232 Binding of TYMS 2 0.11 2.77 0.04
76 INT288765 Positive_regulation of Negative_regulation of Mtr 1 0.12 0.09 0.04
77 INT106364 Positive_regulation of Gene_expression of Tyms 2 0.01 0.65 0
78 INT326142 Positive_regulation of Gene_expression of TYMS 1 0.16 2.47 0
79 INT147145 Negative_regulation of Transcription of TYMS 1 0.15 0 0
80 INT234130 Negative_regulation of Transcription of Tyms 1 0.30 0.13 0
81 INT47058 Positive_regulation of Negative_regulation of MTR 1 0.41 0 0
82 INT47059 Positive_regulation of Positive_regulation of MTR 1 0.44 0 0
83 INT292657 Phosphorylation of FOLR1 1 0.00 0 0
84 INT292658 Negative_regulation of FOLR1 1 0.01 0 0
85 INT234132 Regulation of Transcription of Tyms 1 0.19 0.16 0
86 INT234137 Regulation of Gene_expression of Tyms 1 0.19 0.16 0
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