GO:0005544

From wiki-pain
Jump to: navigation, search
Name calcium-dependent phospholipid binding
Categary Function
Go Slim No
Go Link GO:0005544
Unique Molecular Interactions 105
Total Molecular Interactions 121
Total Single Events 1391
Pain Genes Associated 17

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for calcium-dependent phospholipid binding. They are ordered first by their pain relevance and then by number of times they were reported for calcium-dependent phospholipid binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT91350 Binding of Pla2g4a and RYBP 1 0.00 1.15 2.65
2 INT287746 Anxa1 Positive_regulation of Gene_expression of Lpar1 1 0.07 1.72 2.46
3 INT166842 Binding of ANXA1 and Nfkb1 1 0.37 1.64 0.95
4 INT317559 Binding of Hint1 and Pla2g4a 1 0.01 0.06 0.94
5 INT270218 P2rx3 Positive_regulation of Pla2g4a 1 0.34 0.63 0.85
6 INT231390 Pla2g4a Regulation of Pla2g2a 1 0.08 0.92 0.77
7 INT231388 Pla2g4a Regulation of Pla2g6 1 0.08 0.92 0.77
8 INT308484 Car2 Positive_regulation of Pla2g4a 1 0.03 1.23 0.65
9 INT172144 IL4 Negative_regulation of Transcription of PLA2G4A 1 0.02 0.82 0.58
10 INT166840 Binding of Anxa1 and Nfkb1 1 0.26 0.82 0.56
11 INT296237 Anxa1 Regulation of Gene_expression of Trpm8 1 0.03 0.57 0.43
12 INT296231 Anxa1 Regulation of Gene_expression of Trpa1 1 0.03 0.57 0.43
13 INT296235 Trpm8 Regulation of Positive_regulation of Anxa1 1 0.03 0.62 0.41
14 INT248146 PLA2G6 Negative_regulation of Phosphorylation of PLA2G4A 1 0.07 0.72 0.4
15 INT270220 Negative_regulation of Ephb1 Negative_regulation of Positive_regulation of Pla2g4a 1 0.13 1 0.36
16 INT287747 Anxa1 Positive_regulation of Lpar1 1 0.04 0 0.29
17 INT287748 Positive_regulation of Anxa1 Positive_regulation of Lpar1 1 0.04 0 0.29
18 INT194977 Binding of Alox5 and Syt1 1 0.04 0.65 0.27
19 INT121249 Binding of ANXA5 and CASP3 1 0.36 0.67 0.25
20 INT121250 MEFV Positive_regulation of Binding of ANXA5 1 0.41 0.67 0.25
21 INT332481 ANXA1 Regulation of SGPP2 1 0.45 1.01 0.22
22 INT293056 Binding of ANXA5 and GOPC 1 0.06 0.51 0.19
23 INT303058 Akt1 Negative_regulation of Gene_expression of Syt1 1 0.21 0.43 0.18
24 INT146744 Binding of NR3C1 and PLA2G4A 1 0.26 0.25 0.15
25 INT334770 Ednra Positive_regulation of Pla2g4a 1 0.00 0.24 0.14
26 INT296233 Binding of Anxa1 and Trpa1 1 0.03 0.78 0.14
27 INT332485 SGPP2 Regulation of ANXA1 1 0.27 0.69 0.13
28 INT214953 Syt1 Regulation of Rims1 1 0.25 0 0.12
29 INT146743 Positive_regulation of Binding of GSR and PLA2G4A 1 0.40 0.14 0.11
30 INT146742 Binding of GSR and PLA2G4A 1 0.28 0.14 0.11
31 INT214955 Binding of Syt1 and Vamp2 1 0.22 0 0.1
32 INT214014 Binding of Dysf and Nav1 1 0.00 0.5 0.1
33 INT327557 Pla2g4a Positive_regulation of Phosphorylation of Ptgs2 1 0.14 1.03 0.1
34 INT214951 Binding of Syt1 and Vamp1 1 0.22 0 0.1
35 INT311738 Binding of Anxa1 and Plat 1 0.19 0.63 0.1
36 INT327559 Pla2g4a Positive_regulation of Gene_expression of Ptgs2 1 0.14 1 0.09
37 INT197776 Pla2g10 Regulation of Pla2g4a 1 0.18 0.61 0.08
38 INT303055 Akt1 Negative_regulation of Syt1 1 0.21 0 0.07
39 INT234606 Tlr4 Positive_regulation of Transcription of PLA2G4A 1 0.57 0 0.06
40 INT242475 Ciapin1 Positive_regulation of Gene_expression of Anxa2 1 0.01 1.13 0.06
41 INT303086 Binding of Mafk and Syt1 1 0.23 0.18 0.05
42 INT303057 Binding of Syn1 and Syt1 1 0.07 0.19 0.05
43 INT296236 Anxa1 Positive_regulation of Trpm8 1 0.04 0.09 0.05
44 INT303059 Binding of Syt1 and Sdcbp 1 0.04 0.19 0.05
45 INT332484 ANXA1 Positive_regulation of HSH2D 1 0.18 0.19 0.05
46 INT206845 ANXA1 Regulation of Gene_expression of ESR1 1 0.07 0.9 0.04
47 INT296232 Anxa1 Regulation of Trpm8 1 0.03 0.54 0.04
48 INT255659 Binding of Anxa5 and Ca2 1 0.02 1.23 0.04
49 INT249199 CA2 Positive_regulation of PLA2G4A 1 0.15 0 0.04
50 INT303557 Binding of Dysf and Fgf22 1 0.01 0.45 0.03
51 INT195837 Tlr4 Positive_regulation of Pla2g4a 1 0.01 0.44 0.03
52 INT303054 Rorb Positive_regulation of Gene_expression of Syt1 1 0.01 0 0.03
53 INT222532 Anxa1 Negative_regulation of Localization of Gh1 1 0.01 0.14 0.03
54 INT303558 Binding of Fgfr2 and Dysf 1 0.01 0.44 0.03
55 INT222538 Anxa1 Negative_regulation of Localization of Prl 1 0.04 0.14 0.03
56 INT348362 Binding of C2 and Positive_regulation of Localization of PLA2G4A 1 0.02 0.37 0.03
57 INT303563 Binding of Fgf10 and Dysf 1 0.00 0.44 0.03
58 INT303559 Binding of Fgf7 and Dysf 1 0.01 0.44 0.03
59 INT222475 Anxa1 Negative_regulation of Localization of LH 1 0.01 0.14 0.03
60 INT260318 Binding of PROC and Anxa5 1 0.00 0 0
61 INT180862 Binding of ANXA2 and S100A10 1 0.17 0.82 0
62 INT254745 Binding of Anxa3 and Skil 1 0.00 0 0
63 INT293055 Binding of ANXA5 and PRSS1 1 0.00 0.59 0
64 INT65036 Fgf1 Regulation of Anxa5 1 0.01 0.35 0
65 INT206844 ESR1 Positive_regulation of Gene_expression of ANXA1 1 0.08 0.1 0
66 INT249179 PLA2G4A Regulation of CYBB 1 0.18 0 0
67 INT332487 ANXA1 Regulation of Gene_expression of SGPP2 1 0.45 0.08 0
68 INT249191 CYBB Positive_regulation of PLA2G4A 1 0.20 0 0
69 INT249187 Binding of CYBB and PLA2G4A 1 0.14 0 0
70 INT283343 Binding of Srr and Pclo 1 0.05 0 0
71 INT272197 Binding of CAPN3 and DYSF 1 0.42 0.38 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for calcium-dependent phospholipid binding. They are ordered first by their pain relevance and then by number of times they were reported in calcium-dependent phospholipid binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT113399 Positive_regulation of Pla2g4a 36 0.67 33.83 18.78
2 INT187513 Positive_regulation of Pla2g4a 5 0.62 34.09 18.22
3 INT195831 Phosphorylation of Pla2g4a 15 0.74 34.43 17.14
4 INT270238 Localization of Pla2g4a 1 0.72 17.99 11.35
5 INT86813 Gene_expression of Pla2g4a 26 0.75 42.31 10.07
6 INT62544 Gene_expression of Anxa1 21 0.47 13.56 9.71
7 INT141751 Localization of Syt1 21 0.78 11.19 5.98
8 INT141750 Positive_regulation of Localization of Syt1 10 0.67 5.53 5.28
9 INT106274 Positive_regulation of Syt1 16 0.67 9.76 4.1
10 INT64864 Gene_expression of PLA2G4A 18 0.77 10.45 4.09
11 INT162125 Gene_expression of Pla2g4a 4 0.54 7.69 3.75
12 INT85497 Gene_expression of Anxa1 6 0.77 4.7 3.68
13 INT22578 Gene_expression of Syt1 43 0.77 11.02 3.66
14 INT46725 Localization of Anxa3 4 0.48 4.53 3.43
15 INT62547 Positive_regulation of Gene_expression of Anxa1 5 0.42 4.52 3.27
16 INT270224 Positive_regulation of Positive_regulation of Pla2g4a 1 0.62 6.63 3.22
17 INT48042 Positive_regulation of Anxa1 5 0.50 3.64 3.19
18 INT134798 Gene_expression of ANXA1 15 0.75 13.94 2.99
19 INT151268 Phosphorylation of Syt1 4 0.61 1.65 2.95
20 INT126172 Negative_regulation of Pla2g4a 7 0.39 9.01 2.89
21 INT141752 Negative_regulation of Localization of Syt1 5 0.42 4.96 2.68
22 INT96092 Binding of ANXA5 24 0.36 14.51 2.6
23 INT122376 Localization of Pla2g4a 12 0.73 7.18 2.58
24 INT165726 Positive_regulation of Anxa1 7 0.29 3.16 2.57
25 INT132419 Positive_regulation of ANXA5 9 0.59 5.22 2.38
26 INT270235 Negative_regulation of Phosphorylation of Pla2g4a 1 0.39 3.4 2.34
27 INT17961 Regulation of Pla2g4a 9 0.25 4.86 2.3
28 INT152076 Negative_regulation of Pla2g4a 3 0.55 3.22 2.21
29 INT166838 Positive_regulation of ANXA1 4 0.64 4.88 2.16
30 INT86814 Transcription of Pla2g4a 4 0.49 2.35 2.14
31 INT70066 Positive_regulation of Localization of Anxa3 1 0.01 2.34 2.14
32 INT195828 Positive_regulation of Phosphorylation of Pla2g4a 3 0.45 5.05 2.12
33 INT64676 Gene_expression of ANXA5 11 0.75 13.48 2.11
34 INT151272 Positive_regulation of Phosphorylation of Syt1 2 0.45 0.32 1.93
35 INT129168 Binding of Anxa5 8 0.41 9.53 1.91
36 INT85498 Positive_regulation of Gene_expression of Anxa1 3 0.50 2.12 1.7
37 INT91773 Positive_regulation of PLA2G4A 10 0.50 4.4 1.54
38 INT91764 Positive_regulation of Gene_expression of PLA2G4A 8 0.69 5.43 1.52
39 INT85499 Regulation of Anxa1 1 0.27 1.88 1.52
40 INT270223 Negative_regulation of Localization of Pla2g4a 1 0.39 1.83 1.5
41 INT106273 Positive_regulation of Positive_regulation of Syt1 2 0.29 1.22 1.42
42 INT171147 Binding of Syt1 7 0.35 6.11 1.36
43 INT268619 Phosphorylation of Pla2g4a 5 0.69 2.14 1.36
44 INT133255 Gene_expression of Anxa2 8 0.41 8.52 1.3
45 INT86812 Negative_regulation of Transcription of Pla2g4a 1 0.13 0.49 1.18
46 INT64863 Localization of PLA2G4A 9 0.44 3.33 1.07
47 INT71233 Negative_regulation of Anxa1 1 0.07 0.15 1.05
48 INT195832 Regulation of Phosphorylation of Pla2g4a 3 0.34 2.91 1.02
49 INT162126 Positive_regulation of Gene_expression of Pla2g4a 4 0.42 2.52 1.01
50 INT228871 Negative_regulation of Gene_expression of Anxa1 2 0.03 1.92 1.01
51 INT122151 Localization of Anxa1 1 0.75 0.53 1
52 INT65166 Negative_regulation of PLA2G4A 7 0.57 1.55 0.96
53 INT132417 Transcription of ANXA5 2 0.59 1.82 0.95
54 INT86816 Negative_regulation of Gene_expression of Pla2g4a 3 0.50 2.27 0.93
55 INT270236 Regulation of Localization of Pla2g4a 1 0.24 1.68 0.93
56 INT270231 Regulation of Positive_regulation of Pla2g4a 1 0.24 1.92 0.92
57 INT205888 Positive_regulation of Gene_expression of Pla2g4a 7 0.67 8 0.9
58 INT48811 Regulation of Anxa5 2 0.13 0.26 0.9
59 INT57954 Negative_regulation of Anxa3 4 0.11 4.51 0.89
60 INT168990 Positive_regulation of Positive_regulation of Pla2g4a 2 0.43 2.14 0.86
61 INT77928 Binding of Pla2g4a 3 0.10 2.5 0.84
62 INT270226 Negative_regulation of Positive_regulation of Pla2g4a 1 0.38 2.34 0.84
63 INT88425 Negative_regulation of DYSF 4 0.57 4.68 0.83
64 INT93576 Negative_regulation of Dysf 3 0.54 1.79 0.82
65 INT295239 Negative_regulation of Anxa1 2 0.02 1.6 0.81
66 INT146746 Transcription of PLA2G4A 3 0.69 1.03 0.8
67 INT132418 Positive_regulation of Transcription of ANXA5 1 0.43 0.1 0.78
68 INT93577 Positive_regulation of Dysf 2 0.46 0.75 0.77
69 INT113400 Positive_regulation of Transcription of Pla2g4a 1 0.08 0.96 0.7
70 INT308475 Regulation of Positive_regulation of Pla2g4a 1 0.09 1.14 0.67
71 INT22577 Positive_regulation of Gene_expression of Syt1 6 0.50 1.49 0.65
72 INT166836 Negative_regulation of Positive_regulation of ANXA1 2 0.39 1.15 0.57
73 INT122149 Binding of Anxa1 1 0.36 0.22 0.57
74 INT208285 Gene_expression of Anxa5 10 0.64 7.02 0.56
75 INT37750 Localization of ANXA1 2 0.74 1.72 0.56
76 INT327659 Regulation of Syt1 1 0.20 0 0.56
77 INT270227 Positive_regulation of Localization of Pla2g4a 1 0.45 1.31 0.56
78 INT78775 Regulation of PLA2G4A 4 0.25 1.45 0.55
79 INT37749 Positive_regulation of Localization of ANXA1 1 0.01 0.67 0.53
80 INT76858 Binding of PLA2G4A 4 0.30 1.22 0.52
81 INT206876 Positive_regulation of Gene_expression of ANXA1 3 0.39 1.68 0.51
82 INT166837 Binding of ANXA1 2 0.34 0.85 0.51
83 INT254731 Gene_expression of Anxa3 2 0.20 0.98 0.49
84 INT206858 Regulation of ANXA1 3 0.56 2.4 0.45
85 INT270229 Binding of Pla2g4a 1 0.29 1.23 0.45
86 INT122150 Positive_regulation of Localization of Anxa1 1 0.47 0.28 0.44
87 INT166839 Negative_regulation of ANXA1 1 0.37 0.88 0.43
88 INT94347 Gene_expression of DYSF 4 0.75 3.25 0.41
89 INT146045 Regulation of Gene_expression of Syt1 4 0.21 0.84 0.4
90 INT36781 Binding of Pclo 1 0.23 0 0.39
91 INT248153 Phosphorylation of PLA2G4A 1 0.20 0.65 0.38
92 INT126173 Negative_regulation of Regulation of Pla2g4a 1 0.40 1.01 0.37
93 INT203309 Regulation of Anxa2 1 0.42 1.03 0.35
94 INT168569 Binding of Anxa3 1 0.36 0.53 0.34
95 INT126174 Positive_regulation of Regulation of Pla2g4a 1 0.37 1.03 0.34
96 INT205894 Regulation of Gene_expression of Pla2g4a 3 0.52 1.9 0.33
97 INT146747 Negative_regulation of Gene_expression of PLA2G4A 1 0.43 0.66 0.33
98 INT117968 Regulation of Anxa1 1 0.39 1.36 0.31
99 INT106271 Negative_regulation of Positive_regulation of Syt1 1 0.25 0.34 0.3
100 INT354299 Positive_regulation of Syt1 1 0.67 0.1 0.27
101 INT126171 Negative_regulation of Positive_regulation of Pla2g4a 1 0.39 0.91 0.27
102 INT160928 Negative_regulation of Syt1 4 0.57 1.9 0.25
103 INT293061 Regulation of Binding of ANXA5 1 0.12 0.58 0.25
104 INT15591 Positive_regulation of Anxa5 4 0.41 5.66 0.23
105 INT308821 Localization of Anxa5 2 0.62 1.27 0.23
106 INT312523 Negative_regulation of Phosphorylation of Pla2g4a 1 0.16 0.68 0.22
107 INT312522 Positive_regulation of Phosphorylation of Pla2g4a 1 0.14 0.68 0.21
108 INT101226 Binding of Anxa2 3 0.05 0 0.2
109 INT221896 Protein_catabolism of Syt1 2 0.22 0.36 0.2
110 INT293062 Negative_regulation of Binding of ANXA5 2 0.11 1.11 0.18
111 INT320010 Positive_regulation of Gene_expression of Anxa3 1 0.11 0.26 0.18
112 INT146748 Positive_regulation of Transcription of PLA2G4A 1 0.50 0.22 0.17
113 INT258270 Binding of Anxa5 6 0.16 3.74 0.16
114 INT119605 Positive_regulation of Anxa5 2 0.67 2.3 0.16
115 INT182457 Gene_expression of Anxa5 9 0.65 3.67 0.15
116 INT140233 Positive_regulation of DYSF 1 0.41 0.74 0.15
117 INT195826 Negative_regulation of Gene_expression of Pla2g4a 1 0.28 1.38 0.15
118 INT195829 Regulation of Pla2g4a 1 0.20 2.54 0.15
119 INT112614 Positive_regulation of ANXA2 1 0.59 0.09 0.14
120 INT287734 Binding of Anxa1 1 0.03 0.18 0.14
121 INT169728 Negative_regulation of Anxa5 2 0.31 0.33 0.13
122 INT84395 Protein_catabolism of Pla2g4a 1 0.02 0.41 0.12
123 INT296223 Regulation of Localization of Anxa1 1 0.03 0.35 0.11
124 INT331972 Positive_regulation of Gene_expression of DYSF 1 0.28 0.48 0.11
125 INT296227 Localization of Anxa1 1 0.05 0.34 0.11
126 INT228594 Regulation of Gene_expression of ANXA5 1 0.04 0.36 0.11
127 INT351388 Positive_regulation of Binding of Syt1 1 0.11 0.33 0.1
128 INT303069 Transcription of Syt1 1 0.41 0 0.09
129 INT290117 Negative_regulation of Gene_expression of ANXA1 1 0.57 1.15 0.08
130 INT190861 Binding of Syt1 1 0.03 0.55 0.08
131 INT155707 Localization of DYSF 1 0.73 0.17 0.08
132 INT32433 Regulation of Anxa3 2 0.04 1.21 0.07
133 INT133256 Transcription of Anxa2 1 0.04 1.5 0.07
134 INT253445 Positive_regulation of Binding of Pla2g4a 1 0.12 0.91 0.06
135 INT351387 Regulation of Syt1 1 0.11 0.32 0.05
136 INT206862 Regulation of Gene_expression of ANXA1 2 0.18 1.76 0.04
137 INT332510 Protein_catabolism of ANXA1 1 0.60 0.08 0.04
138 INT250020 Negative_regulation of Anxa5 1 0.25 1.15 0.04
139 INT53928 Positive_regulation of Anxa3 1 0.00 0.07 0.04
140 INT249275 Positive_regulation of Localization of PLA2G4A 1 0.25 0 0.04
141 INT250019 Positive_regulation of Gene_expression of Anxa5 1 0.23 1.3 0.03
142 INT283320 Localization of Pclo 1 0.14 0 0.03
143 INT296228 Positive_regulation of Positive_regulation of Anxa1 1 0.03 0.34 0.03
144 INT217377 Gene_expression of Dysf 6 0.71 2.28 0
145 INT143410 Regulation of Localization of PLA2G4A 2 0.34 0 0
146 INT171149 Negative_regulation of Gene_expression of Syt1 2 0.45 0.22 0
147 INT195830 Regulation of Regulation of Pla2g4a 1 0.20 0.62 0
148 INT202685 Positive_regulation of Gene_expression of ANXA5 1 0.08 0.85 0
149 INT355390 Transcription of Anxa5 1 0.44 0.39 0
150 INT191180 Negative_regulation of ANXA5 1 0.04 0.62 0
151 INT283321 Gene_expression of Pclo 1 0.12 0 0
152 INT294612 Positive_regulation of Positive_regulation of Dysf 1 0.46 0.19 0
153 INT337080 Positive_regulation of Localization of Pla2g4a 1 0.18 1 0
154 INT301391 Protein_catabolism of Anxa1 1 0.01 1.03 0
155 INT330707 Localization of Anxa2 1 0.02 1.13 0
156 INT260313 Positive_regulation of Gene_expression of Anxa5 1 0.10 0 0
157 INT322342 Negative_regulation of Gene_expression of Anxa5 1 0.07 0.36 0
158 INT272207 Binding of DYSF 1 0.36 0.56 0
159 INT294613 Binding of Dysf 1 0.34 0.56 0
160 INT259024 Regulation of Anxa5 1 0.44 1.25 0
161 INT294615 Localization of Dysf 1 0.69 0.35 0
Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox