GO:0005546

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Name phosphatidylinositol-4,5-bisphosphate binding
Categary Function
Go Slim No
Go Link GO:0005546
Unique Molecular Interactions 37
Total Molecular Interactions 58
Total Single Events 138
Pain Genes Associated 13

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for phosphatidylinositol-4,5-bisphosphate binding. They are ordered first by their pain relevance and then by number of times they were reported for phosphatidylinositol-4,5-bisphosphate binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT147652 PLCB1 Negative_regulation of Positive_regulation of TRPV1 1 0.27 0.92 1.62
2 INT106992 F2 Positive_regulation of PARD3 3 0.05 1.83 0.72
3 INT8980 Gal Regulation of PLCB1 1 0.18 0.13 0.68
4 INT338044 F2 Positive_regulation of Pard3 1 0.08 0.38 0.4
5 INT157957 Ppyr1 Negative_regulation of Phosphorylation of PLCB1 1 0.00 0.24 0.24
6 INT118857 PLCB1 Regulation of Phosphorylation of SRC 1 0.01 0.15 0.24
7 INT339516 Binding of Eif2ak2 and TIRAP 1 0.25 0.19 0.23
8 INT343854 TIRAP Positive_regulation of IRF3 1 0.06 0.19 0.19
9 INT254214 Binding of Myd88 and Tirap 1 0.15 0.55 0.17
10 INT106994 PARD3 Positive_regulation of PAR4 1 0.21 0.28 0.14
11 INT107006 PARD3 Positive_regulation of SPG21 1 0.24 0.29 0.14
12 INT59808 Binding of AGT and PLCB1 1 0.02 0 0.13
13 INT106997 PARD3 Positive_regulation of NR1I2 1 0.19 0.28 0.13
14 INT59809 AGT Positive_regulation of PLCB1 1 0.03 0 0.13
15 INT59807 ADRA1D Positive_regulation of PLCB1 1 0.33 0 0.13
16 INT338041 F2r Positive_regulation of Pard3 1 0.15 0.05 0.11
17 INT338048 F2rl3 Positive_regulation of Pard3 1 0.11 0.05 0.11
18 INT343845 TICAM1 Positive_regulation of TIRAP 1 0.05 0.25 0.09
19 INT356112 Binding of App and Apba1 1 0.24 0.29 0.09
20 INT257665 Binding of Nphs1 and Pard3 1 0.39 0.67 0.09
21 INT214752 EDNRA Positive_regulation of PLCB1 1 0.02 0 0.08
22 INT337888 Ins1 Positive_regulation of Gene_expression of Ldlrap1 1 0.06 0 0.08
23 INT115933 U Regulation of PLCB1 1 0.00 0.3 0.08
24 INT337889 Binding of Ins1 and Ldlrap1 1 0.06 0.27 0.08
25 INT343865 IRF6 Positive_regulation of TIRAP 1 0.03 0.28 0.08
26 INT242475 Ciapin1 Positive_regulation of Gene_expression of Anxa2 1 0.01 1.13 0.06
27 INT350482 Tirap Regulation of TICAM2 1 0.05 0.06 0.06
28 INT350478 Tirap Regulation of Ticam1 1 0.07 0.06 0.05
29 INT238619 Binding of Apba1 and Regulation of Localization of Grin2d 1 0.01 0 0.05
30 INT180862 Binding of ANXA2 and S100A10 1 0.17 0.82 0
31 INT321772 Binding of Myo7a and Twf2 1 0.00 0 0
32 INT215246 Binding of Rab27a and Rph3a 1 0.07 0.26 0
33 INT257666 Binding of Mgst1 and Pard3 1 0.05 0 0
34 INT338047 Binding of F2r and Pard3 1 0.11 0 0
35 INT215241 Binding of Rab3a and Rph3a 1 0.00 0.26 0
36 INT263584 Hspa5 Positive_regulation of Myo1b 1 0.00 1.02 0
37 INT257664 Regulation of Binding of Nphs1 and Pard3 1 0.36 0 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for phosphatidylinositol-4,5-bisphosphate binding. They are ordered first by their pain relevance and then by number of times they were reported in phosphatidylinositol-4,5-bisphosphate binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT59818 Negative_regulation of PLCB1 7 0.57 2.24 2.28
2 INT118511 Gene_expression of Pard3 5 0.57 0.76 1.86
3 INT133255 Gene_expression of Anxa2 8 0.41 8.52 1.3
4 INT59815 Positive_regulation of PLCB1 9 0.67 1.12 1.22
5 INT124092 Gene_expression of Myo1b 3 0.41 1.22 0.82
6 INT124091 Negative_regulation of Gene_expression of Myo1b 1 0.04 1.08 0.8
7 INT150608 Regulation of Apba1 1 0.00 1.27 0.69
8 INT59817 Gene_expression of PLCB1 4 0.75 0.73 0.65
9 INT327674 Regulation of Apba1 1 0.22 0 0.56
10 INT284454 Binding of Tirap 4 0.26 2.07 0.49
11 INT157955 Phosphorylation of PLCB1 1 0.01 0.46 0.46
12 INT243089 Gene_expression of Ldlrap1 2 0.65 0.14 0.35
13 INT203309 Regulation of Anxa2 1 0.42 1.03 0.35
14 INT74604 Negative_regulation of Gene_expression of PLCB1 1 0.41 0.25 0.35
15 INT59816 Positive_regulation of Gene_expression of PLCB1 2 0.49 0.22 0.31
16 INT235857 Binding of PLCB1 1 0.36 0.35 0.29
17 INT139808 Gene_expression of Apba1 2 0.29 0.92 0.27
18 INT208930 Positive_regulation of Pard3 2 0.33 0.49 0.27
19 INT324677 Gene_expression of Tirap 3 0.47 0.21 0.26
20 INT139810 Gene_expression of Apba1 1 0.00 0.87 0.24
21 INT157956 Regulation of Phosphorylation of PLCB1 1 0.00 0.22 0.22
22 INT101226 Binding of Anxa2 3 0.05 0 0.2
23 INT74602 Negative_regulation of Positive_regulation of PLCB1 1 0.41 0.25 0.19
24 INT112614 Positive_regulation of ANXA2 1 0.59 0.09 0.14
25 INT243075 Regulation of Gene_expression of Ldlrap1 2 0.44 0.15 0.13
26 INT337866 Binding of Ldlrap1 1 0.18 0.56 0.12
27 INT229402 Positive_regulation of PARD3 1 0.11 0.8 0.11
28 INT343883 Gene_expression of TIRAP 2 0.65 0.28 0.09
29 INT343902 Positive_regulation of Gene_expression of TIRAP 1 0.22 0.28 0.09
30 INT59820 Regulation of Gene_expression of PLCB1 1 0.44 0 0.09
31 INT115930 Regulation of PLCB1 1 0.02 0.29 0.08
32 INT238599 Binding of Apba1 1 0.08 0 0.07
33 INT74606 Regulation of Negative_regulation of PLCB1 1 0.44 0.19 0.07
34 INT133256 Transcription of Anxa2 1 0.04 1.5 0.07
35 INT343889 Positive_regulation of TIRAP 1 0.20 0.11 0.06
36 INT267753 Negative_regulation of Apba1 1 0.01 0.43 0.05
37 INT275845 Binding of Apba1 1 0.04 0.5 0.05
38 INT257639 Binding of Pard3 1 0.35 0.4 0.04
39 INT59814 Positive_regulation of Negative_regulation of PLCB1 1 0.45 0 0.04
40 INT339489 Binding of TIRAP 1 0.36 0.05 0.03
41 INT345270 Negative_regulation of Tirap 1 0.02 0.15 0
42 INT263567 Positive_regulation of Myo1b 1 0.01 1.01 0
43 INT254185 Positive_regulation of Tirap 1 0.32 0 0
44 INT254183 Regulation of Positive_regulation of Tirap 1 0.29 0 0
45 INT321731 Positive_regulation of Gene_expression of Twf2 1 0.15 0 0
46 INT321750 Localization of Twf2 1 0.17 0 0
47 INT254176 Positive_regulation of Positive_regulation of Tirap 1 0.32 0 0
48 INT330707 Localization of Anxa2 1 0.02 1.13 0
49 INT321740 Gene_expression of Twf2 1 0.17 0 0
50 INT257646 Positive_regulation of Gene_expression of Pard3 1 0.51 0 0
51 INT321754 Binding of Twf2 1 0.08 0 0
52 INT353775 Negative_regulation of Ldlrap1 1 0.02 1 0
53 INT276546 Regulation of Myo1b 1 0.16 0 0
54 INT243095 Positive_regulation of Ldlrap1 1 0.49 0.18 0
55 INT257653 Negative_regulation of Binding of Pard3 1 0.32 0.07 0
56 INT243072 Transcription of Ldlrap1 1 0.67 0 0
57 INT321746 Regulation of Gene_expression of Twf2 1 0.10 0 0
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