GO:0005579

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Name membrane attack complex
Categary Component
Go Slim No
Go Link GO:0005579
Unique Molecular Interactions 48
Total Molecular Interactions 56
Total Single Events 369
Pain Genes Associated 11

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for membrane attack complex. They are ordered first by their pain relevance and then by number of times they were reported for membrane attack complex. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT329962 Binding of C5 and HEPACAM 1 0.03 2.25 1.06
2 INT252858 C5 Negative_regulation of Positive_regulation of Trpa1 1 0.02 0.78 0.74
3 INT251171 Clu Positive_regulation of C6 1 0.05 0.75 0.67
4 INT313650 Binding of C8A and TRGC1 1 0.01 0.49 0.5
5 INT329960 Binding of C5 and TRAF1 1 0.32 1.04 0.42
6 INT329958 Binding of C5 and STAT4 1 0.33 0.93 0.41
7 INT203140 Binding of C5ar1 and C5 1 0.39 0.81 0.38
8 INT320694 C5 Regulation of Gene_expression of Il2 1 0.03 2.15 0.34
9 INT320692 C5 Regulation of Gene_expression of Il12a 1 0.03 2.15 0.34
10 INT320693 C5 Regulation of Gene_expression of Il6 1 0.04 2.15 0.34
11 INT320696 C5 Regulation of Gene_expression of TNF 1 0.34 2.15 0.34
12 INT320691 C5 Regulation of Gene_expression of Il1 1 0.06 2.15 0.34
13 INT332013 Hc Regulation of Binding of C3ar1 1 0.12 1.11 0.21
14 INT332016 C3ar1 Regulation of Binding of Hc 1 0.12 1.11 0.21
15 INT309661 C5 Positive_regulation of Phosphorylation of Akt1 1 0.51 0.45 0.21
16 INT183443 C7 Positive_regulation of POSTN 1 0.00 0 0.19
17 INT244840 Lbx1 Negative_regulation of C9 1 0.13 0.09 0.16
18 INT238258 C7 Negative_regulation of C6 1 0.09 0.24 0.13
19 INT238259 Regulation of C7 Negative_regulation of C6 1 0.06 0.24 0.13
20 INT289404 Mthfd1 Positive_regulation of Hc 1 0.04 0.58 0.12
21 INT309662 C5 Positive_regulation of Akt1 1 0.30 0.43 0.11
22 INT41832 Binding of ALB and C5 1 0.41 0.07 0.08
23 INT279502 Binding of C2 and Hc 1 0.01 0.2 0.07
24 INT313649 C8A Regulation of ISYNA1 1 0.00 0.12 0.06
25 INT218511 Cfb Positive_regulation of C5 1 0.01 0.29 0.06
26 INT313652 C8A Regulation of CPOX 1 0.00 0.11 0.06
27 INT299703 ECB2 Negative_regulation of Binding of C5 1 0.00 0.39 0.06
28 INT320991 C5AR1 Regulation of C5 1 0.05 0 0.03
29 INT313656 C8A Regulation of Gene_expression of ISYNA1 1 0.00 0.06 0.03
30 INT279698 Hc Regulation of Trpv1 1 0.01 0 0
31 INT229923 Binding of ABCA1 and C9 1 0.00 0.74 0
32 INT299705 C5 Positive_regulation of Positive_regulation of C5AR1 1 0.03 0.1 0
33 INT218505 Binding of C5 and Cfb 1 0.01 0.29 0
34 INT239913 Binding of C7 and C8B 1 0.18 0.06 0
35 INT279695 Hc Negative_regulation of Car2 1 0.02 0 0
36 INT218531 Binding of C6 and TCN2 1 0.00 0 0
37 INT279696 Hc Negative_regulation of Trpv1 1 0.01 0 0
38 INT313654 C8A Negative_regulation of PLA2G2D 1 0.02 0 0
39 INT229922 Binding of C9 and CD59 1 0.08 0.72 0
40 INT313657 C8A Negative_regulation of TRGC1 1 0.01 0 0
41 INT218532 Binding of C5 and LCN1 1 0.06 0.49 0
42 INT279694 Hc Negative_regulation of Catsper1 1 0.05 0 0
43 INT289411 Binding of C9 and Ivns1abp 1 0.01 0.54 0
44 INT234306 Binding of Gria4 and Hc 1 0.01 0 0
45 INT265546 Gla Regulation of C6 1 0.01 0.98 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for membrane attack complex. They are ordered first by their pain relevance and then by number of times they were reported in membrane attack complex. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT6507 Binding of C5 23 0.48 15.35 3.91
2 INT69904 Binding of Hc 11 0.35 7.79 3.69
3 INT107074 Gene_expression of C5 14 0.75 9.87 3.64
4 INT135963 Negative_regulation of Hc 19 0.42 12.36 3.63
5 INT145774 Positive_regulation of C5 7 0.67 4.88 2.79
6 INT64147 Gene_expression of C5 15 0.60 16.8 2.78
7 INT160093 Gene_expression of C7 12 0.67 5.44 2.73
8 INT121683 Gene_expression of Hc 23 0.75 7.15 2.7
9 INT33848 Binding of C6 6 0.36 0.88 2.04
10 INT135961 Positive_regulation of Hc 8 0.67 3.67 1.87
11 INT53493 Negative_regulation of C6 3 0.53 2.68 1.77
12 INT157719 Gene_expression of C6 8 0.67 3.41 1.74
13 INT26426 Localization of C5 5 0.78 3.87 1.61
14 INT212790 Regulation of C5 6 0.24 6.04 1.59
15 INT118265 Positive_regulation of C7 4 0.23 0.92 1.52
16 INT107942 Positive_regulation of C5 9 0.50 6.86 1.19
17 INT185943 Gene_expression of C8A 3 0.06 3.14 1.16
18 INT145773 Positive_regulation of Localization of C5 1 0.49 1.15 1.06
19 INT110076 Regulation of C6 2 0.22 1.14 0.96
20 INT35292 Negative_regulation of C5 7 0.43 5.3 0.86
21 INT131066 Binding of C6 4 0.31 1.81 0.86
22 INT184351 Localization of Hc 2 0.20 2.33 0.83
23 INT269693 Regulation of Negative_regulation of Hc 1 0.00 0.09 0.83
24 INT313673 Negative_regulation of C8A 1 0.04 0.85 0.82
25 INT329967 Positive_regulation of Gene_expression of C5 1 0.42 1.63 0.81
26 INT41656 Regulation of C7 1 0.23 0 0.8
27 INT121684 Positive_regulation of Gene_expression of Hc 3 0.67 1.56 0.69
28 INT161201 Localization of C5 2 0.75 0.93 0.69
29 INT252856 Positive_regulation of Positive_regulation of C5 1 0.02 0.95 0.67
30 INT157225 Negative_regulation of Gene_expression of Hc 2 0.12 1.12 0.66
31 INT148686 Localization of C6 5 0.31 4.27 0.64
32 INT203146 Protein_catabolism of C5 1 0.64 1.62 0.64
33 INT166437 Binding of C5 4 0.36 3.28 0.63
34 INT184367 Protein_catabolism of Hc 4 0.26 2.66 0.6
35 INT107652 Gene_expression of C7 4 0.60 2.06 0.56
36 INT22509 Positive_regulation of C6 3 0.43 0.48 0.51
37 INT85081 Protein_catabolism of C5 5 0.19 1.34 0.5
38 INT185946 Positive_regulation of C9 6 0.23 6.51 0.46
39 INT570 Negative_regulation of C6 2 0.06 0.31 0.46
40 INT185951 Gene_expression of C9 7 0.65 5.84 0.45
41 INT238257 Localization of C7 1 0.38 1.45 0.43
42 INT140435 Binding of C7 3 0.32 1.13 0.36
43 INT27059 Negative_regulation of C5 2 0.42 1.87 0.35
44 INT183446 Positive_regulation of C6 4 0.30 0.77 0.33
45 INT207775 Negative_regulation of Gene_expression of C5 4 0.42 2.08 0.33
46 INT157615 Regulation of C9 1 0.00 0 0.33
47 INT313683 Binding of C8A 1 0.03 0.07 0.26
48 INT198564 Regulation of C9 1 0.14 1.67 0.22
49 INT238249 Positive_regulation of Localization of C6 1 0.20 1.2 0.22
50 INT198562 Positive_regulation of Regulation of C9 1 0.23 1.68 0.22
51 INT313679 Regulation of C8A 1 0.04 0.46 0.22
52 INT135960 Regulation of Hc 2 0.44 1.28 0.21
53 INT325473 Regulation of C6 1 0.01 0.91 0.2
54 INT238246 Regulation of Gene_expression of C5 1 0.12 0 0.19
55 INT212788 Regulation of Regulation of C5 1 0.24 0.48 0.18
56 INT212789 Negative_regulation of Gene_expression of C5 2 0.38 1.04 0.17
57 INT230874 Gene_expression of C9 4 0.23 1.88 0.16
58 INT185947 Positive_regulation of Gene_expression of C9 2 0.23 1.43 0.16
59 INT244744 Positive_regulation of C9 1 0.13 0.09 0.16
60 INT198561 Regulation of Gene_expression of C9 1 0.23 1 0.16
61 INT43385 Gene_expression of C6 5 0.58 2.49 0.15
62 INT125712 Regulation of C5 1 0.07 0.07 0.15
63 INT309647 Regulation of Positive_regulation of C5 1 0.44 0.46 0.15
64 INT2805 Negative_regulation of C7 1 0.26 0.73 0.11
65 INT196112 Transcription of Hc 1 0.17 0.08 0.11
66 INT41757 Localization of C6 1 0.69 0 0.1
67 INT313672 Positive_regulation of Binding of C8A 1 0.04 0 0.09
68 INT230875 Binding of C9 2 0.11 1.2 0.06
69 INT310104 Positive_regulation of Protein_catabolism of C6 1 0.16 0.93 0.03
70 INT229966 Binding of C9 3 0.47 2.22 0
71 INT185944 Positive_regulation of C7 2 0.33 0.48 0
72 INT185949 Positive_regulation of Gene_expression of C6 2 0.19 0.43 0
73 INT230876 Localization of C9 2 0.22 0.43 0
74 INT135962 Regulation of Gene_expression of Hc 2 0.60 0.71 0
75 INT310105 Protein_catabolism of C6 1 0.29 1.14 0
76 INT239943 Binding of C8B 1 0.26 0.11 0
77 INT313681 Positive_regulation of C8A 1 0.03 0 0
78 INT299681 Negative_regulation of Positive_regulation of C5 1 0.12 0.17 0
79 INT313674 Positive_regulation of Gene_expression of C8A 1 0.04 0 0
80 INT279442 Negative_regulation of Protein_catabolism of Hc 1 0.04 0 0
81 INT299674 Regulation of Gene_expression of C5 1 0.13 0.18 0
82 INT239931 Positive_regulation of C8B 1 0.16 0.06 0
83 INT239936 Positive_regulation of Binding of C8B 1 0.36 0.06 0
84 INT218474 Negative_regulation of Binding of C5 1 0.06 0.53 0
85 INT185950 Positive_regulation of Gene_expression of C7 1 0.21 0.43 0
86 INT218534 Negative_regulation of Binding of C5 1 0.41 0.23 0
87 INT166335 Positive_regulation of Gene_expression of C7 1 0.43 0.65 0
88 INT239932 Positive_regulation of Binding of C7 1 0.33 0.06 0
89 INT255262 Transcription of C5 1 0.42 3 0
90 INT239937 Binding of C7 1 0.25 0.11 0
91 INT279469 Negative_regulation of Binding of Hc 1 0.05 0 0
92 INT239928 Gene_expression of C8B 1 0.48 0.06 0
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