GO:0005614

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Name interstitial matrix
Categary Component
Go Slim No
Go Link GO:0005614
Unique Molecular Interactions 143
Total Molecular Interactions 191
Total Single Events 1767
Pain Genes Associated 7

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for interstitial matrix. They are ordered first by their pain relevance and then by number of times they were reported for interstitial matrix. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT142177 Calca Positive_regulation of Gene_expression of Igf1 8 0.78 3.57 5.71
2 INT145826 Calca Positive_regulation of Gene_expression of Igf1 3 0.75 3.05 1.66
3 INT351245 Binding of TNC and OPN1LW 1 0.03 0.89 1.31
4 INT106345 Igf1 Regulation of Localization of Acot1 1 0.06 0 1.02
5 INT12141 Igf1 Negative_regulation of Chat 1 0.32 0.63 1
6 INT167466 Ccdc80 Negative_regulation of Tnf 1 0.01 0.76 0.88
7 INT352462 Gse1 Positive_regulation of Gene_expression of Tnc 1 0.05 0.75 0.64
8 INT352459 Gse1 Regulation of Gene_expression of Tnc 1 0.05 0 0.6
9 INT261828 Igf1 Regulation of Localization of Trpv2 1 0.02 1.04 0.58
10 INT156668 Gh Positive_regulation of Igf1 5 0.22 2.07 0.57
11 INT317639 Igf1 Regulation of Creb1 1 0.23 0.16 0.57
12 INT156667 Gh Positive_regulation of Gene_expression of Igf1 6 0.28 0.88 0.56
13 INT150291 Grk1 Positive_regulation of Gene_expression of Igf1 1 0.16 0.98 0.55
14 INT106347 Igf1 Regulation of Chat 1 0.44 0 0.55
15 INT356351 Binding of CALM1 and TNC 1 0.02 0 0.52
16 INT108568 Calca Positive_regulation of Igf1 1 0.51 0.08 0.48
17 INT148818 IL1B Regulation of Gene_expression of TNC 1 0.29 0.57 0.47
18 INT133745 Vcan Regulation of TNC 1 0.11 0.71 0.46
19 INT99304 Igf1 Positive_regulation of Gh1 1 0.44 0.39 0.39
20 INT272951 Binding of TNF and Igf1 1 0.14 1.48 0.36
21 INT272953 Negative_regulation of Binding of TNF and Igf1 1 0.16 1.48 0.36
22 INT63278 Gpm6a Regulation of Igf1 1 0.01 0 0.36
23 INT272952 Igf1 Positive_regulation of Localization of TNF 1 0.19 1.53 0.35
24 INT277656 Igf1 Positive_regulation of Igfbp3 1 0.01 0.4 0.34
25 INT161435 OPA1 Positive_regulation of Gene_expression of Tnc 1 0.02 0.21 0.32
26 INT65268 Igf1 Positive_regulation of Col7a1 1 0.48 0 0.3
27 INT323653 Binding of Igf1 and Igfbp1 1 0.20 1.14 0.29
28 INT352452 Calca Regulation of Gene_expression of Tnc 1 0.04 0 0.28
29 INT352448 Gse1 Regulation of Tnc 1 0.03 0 0.28
30 INT177476 Gnrhr Positive_regulation of Localization of Igf1 1 0.05 1.01 0.28
31 INT352458 Dusp1 Regulation of Gene_expression of Tnc 1 0.07 0 0.28
32 INT50303 Igf1 Regulation of Localization of Gnrhr 1 0.05 0.09 0.27
33 INT97188 Gh Positive_regulation of Localization of Igf1 1 0.02 0.54 0.25
34 INT245590 Ghr Positive_regulation of Gene_expression of Igf1 1 0.34 0.61 0.23
35 INT220383 Binding of Igf1 and Cotl1 1 0.03 0.37 0.22
36 INT299156 Smcp Negative_regulation of Tnc 1 0.05 0.7 0.22
37 INT173946 Igf1 Regulation of Gene_expression of IGF1 1 0.08 0.68 0.21
38 INT173944 IGF1 Regulation of Gene_expression of Igf1 1 0.08 0.68 0.21
39 INT286070 Igf1 Regulation of Regulation of Ins1 1 0.10 1.7 0.2
40 INT106825 Ednra Negative_regulation of Igf1 1 0.07 0.07 0.2
41 INT286071 Igf1 Regulation of Ins1 1 0.10 1.69 0.2
42 INT250537 Ptpn6 Negative_regulation of Igf1 1 0.08 0 0.2
43 INT231033 Igf1 Positive_regulation of Sec22b 1 0.06 0 0.17
44 INT175991 Binding of VEGFA and Igf1 1 0.04 0.57 0.17
45 INT220387 Gh1 Regulation of Localization of Igf1 1 0.05 0.3 0.17
46 INT147229 Positive_regulation of Ccdc80 Negative_regulation of Faah 1 0.02 0.06 0.16
47 INT147230 Ccdc80 Negative_regulation of Faah 1 0.02 0.06 0.16
48 INT334634 Binding of Igf1 and Igf1r 1 0.14 0.45 0.15
49 INT185515 Binding of Igf1 and Csf2 1 0.29 0.4 0.15
50 INT50302 Igf1 Regulation of Gh1 1 0.22 0 0.14
51 INT225778 Igf1 Negative_regulation of Positive_regulation of Ppi-rs 1 0.01 0.82 0.14
52 INT220385 Binding of Igf1 and Gnrhr 1 0.05 0.99 0.14
53 INT220386 Binding of Gh1 and Igf1 1 0.07 0.99 0.14
54 INT65272 Igf1 Positive_regulation of Binding of Col7a1 1 0.42 0 0.14
55 INT65269 Igf1 Positive_regulation of Gene_expression of Lox 1 0.15 0 0.14
56 INT298715 Igf1 Positive_regulation of Gene_expression of PDGFA 1 0.00 0.22 0.14
57 INT253009 Igf1 Regulation of PTTG1 1 0.03 0.44 0.13
58 INT215034 Gh Regulation of Igf1 1 0.13 0.27 0.13
59 INT65267 Igf1 Regulation of Gene_expression of Plod3 1 0.07 0 0.13
60 INT352450 Tnc Regulation of Trib3 1 0.00 0.22 0.13
61 INT65271 Igf1 Positive_regulation of Gene_expression of Plod3 1 0.12 0 0.13
62 INT228453 Igf1 Positive_regulation of Prkca 2 0.12 1.17 0.12
63 INT228456 Igf1 Positive_regulation of Trpv1 1 0.24 0.97 0.12
64 INT308651 Binding of Igf1 and Ins1 1 0.02 0.22 0.11
65 INT175985 Igf1 Positive_regulation of Gene_expression of Serpina1c 1 0.14 0.55 0.11
66 INT341827 Binding of ESR1 and TNC 1 0.14 0.63 0.11
67 INT50301 Igf1 Positive_regulation of Regulation of Gh1 1 0.24 0 0.11
68 INT222507 Igf1 Positive_regulation of Localization of Edn3 1 0.05 0 0.11
69 INT175987 Igf1 Positive_regulation of Serpina1c 1 0.13 0.54 0.11
70 INT50300 Igf1 Positive_regulation of Gene_expression of Ghrh 1 0.26 0 0.11
71 INT51720 Negative_regulation of Ins1 Negative_regulation of Igf1 1 0.12 0.85 0.11
72 INT277657 Igfbp1 Negative_regulation of Negative_regulation of Igf1 1 0.02 0.26 0.1
73 INT161741 Gh1 Positive_regulation of Gene_expression of Igf1 1 0.35 0.55 0.1
74 INT25501 Gnrhr Positive_regulation of Igf1 1 0.12 0.09 0.1
75 INT161742 Gnrhr Positive_regulation of Gene_expression of Igf1 1 0.25 0.55 0.1
76 INT341826 Binding of ERBB2 and TNC 1 0.18 0.63 0.09
77 INT340555 Igf1 Positive_regulation of Mapk1 1 0.24 0.65 0.09
78 INT341825 Binding of TNC and PGR 1 0.14 0.63 0.09
79 INT276141 Binding of Gh and Igf1 2 0.34 0.66 0.08
80 INT49363 Gh Positive_regulation of Igf1 1 0.00 0.49 0.08
81 INT175984 Igf1 Regulation of Localization of Serpina1c 1 0.14 0.54 0.08
82 INT9497 Gh Positive_regulation of Gene_expression of Igf1 1 0.08 0.31 0.08
83 INT325058 Igf1 Positive_regulation of Ang 1 0.04 1.4 0.08
84 INT315987 Rhd Positive_regulation of Gene_expression of Igf1 1 0.10 0.47 0.07
85 INT142348 Igf1 Positive_regulation of Akt1 2 0.50 1.16 0.06
86 INT142346 Igf1 Positive_regulation of Mapk3 1 0.75 0.33 0.06
87 INT295130 Igf1 Regulation of Grxcr1 1 0.02 0.64 0.06
88 INT343481 Epo Positive_regulation of Igf1 1 0.15 0.31 0.06
89 INT142345 Negative_regulation of Igf1 Positive_regulation of Akt1 1 0.42 0.33 0.06
90 INT295128 Igf1 Regulation of Transcription of Pou1f1 1 0.16 0.64 0.06
91 INT250538 Igf1 Positive_regulation of Gh 1 0.24 0.05 0.06
92 INT142347 Negative_regulation of Igf1 Positive_regulation of Mapk3 1 0.46 0.33 0.06
93 INT336338 Glp2r Positive_regulation of Gene_expression of Igf1 1 0.14 0.24 0.05
94 INT335023 Fgf21 Positive_regulation of Gene_expression of Igf1 1 0.49 0.65 0.05
95 INT112282 Ntf3 Regulation of Igf1 1 0.07 0.14 0.05
96 INT206619 Mtpn Positive_regulation of Igf1 1 0.04 0.17 0.05
97 INT112281 Cntf Regulation of Igf1 1 0.22 0.14 0.05
98 INT198358 GH1 Regulation of Igf1 1 0.00 0.09 0.05
99 INT315986 Igf1 Positive_regulation of Pik3c3 1 0.00 0.48 0.05
100 INT184083 Positive_regulation of Gh Positive_regulation of Igf1 1 0.09 0.7 0.04
101 INT184115 Igf1 Positive_regulation of Gene_expression of Socs2 1 0.16 0.62 0.04
102 INT206620 Gh1 Positive_regulation of Igf1 1 0.25 0.17 0.04
103 INT295573 Igf1 Positive_regulation of Gene_expression of Mstn 1 0.19 0 0
104 INT201767 Igf1 Positive_regulation of PIK3CG 1 0.00 0.84 0
105 INT315984 Rhd Positive_regulation of Localization of Igf1 1 0.07 0.25 0
106 INT226190 Binding of Igf1 and Positive_regulation of Pik3cb 1 0.17 1.04 0
107 INT295868 Igf1 Positive_regulation of VEGFA 1 0.16 0.19 0
108 INT200211 Gh Positive_regulation of Localization of Igf1 1 0.38 2.05 0
109 INT218952 Dlst Negative_regulation of Igf1 1 0.03 0.1 0
110 INT295574 Binding of Igf1 and Mstn 1 0.16 0.08 0
111 INT302909 Nav2 Positive_regulation of Arhgef16 1 0.02 0.52 0
112 INT284370 Igf1 Regulation of Gene_expression of VEGFA 1 0.37 0.05 0
113 INT295857 Igf1 Regulation of Localization of Srsf1 1 0.50 0 0
114 INT253007 Igf1 Regulation of Gene_expression of PTTG1 1 0.03 0.46 0
115 INT218954 Dlst Regulation of Gene_expression of Igf1 1 0.03 0 0
116 INT178639 Binding of ESR1 and Igf1 1 0.02 0.39 0
117 INT218951 Negative_regulation of Dlst Negative_regulation of Igf1 1 0.03 0.1 0
118 INT215206 Gh Positive_regulation of Transcription of Igf1 1 0.03 0 0
119 INT17529 Igf1 Regulation of Gh 1 0.01 0.07 0
120 INT215209 Binding of Igf1 and Igfbp3 1 0.11 0 0
121 INT317602 Binding of TNC and PAH 1 0.02 1.74 0
122 INT317843 Binding of TNC and TPSAB1 1 0.01 0.64 0
123 INT17537 Igf1 Regulation of Prl 1 0.00 0 0
124 INT333845 Igf1 Positive_regulation of Gene_expression of Creb1 1 0.21 0.13 0
125 INT17527 Igf1 Regulation of Lhb 1 0.00 0 0
126 INT199369 DST Regulation of Igf1 1 0.02 0.8 0
127 INT74032 Igf1 Positive_regulation of Jun 1 0.48 0.11 0
128 INT79162 Binding of TNC and PLG 1 0.28 0.23 0
129 INT354789 Tnc Regulation of HSPG2 1 0.02 1.38 0
130 INT162437 Binding of Igf1 and Igfals 1 0.10 1.45 0
131 INT289926 Ctrc Negative_regulation of Protein_catabolism of Igf1 1 0.01 0 0
132 INT132069 Binding of Igf1 and Igfbp3 1 0.38 0.08 0
133 INT178637 Igf1 Positive_regulation of ESR1 1 0.03 0.17 0
134 INT80910 Binding of TNC and TNNI3 1 0.21 0.07 0
135 INT278017 Ptprf Regulation of Igf1 1 0.48 0.31 0
136 INT178628 Igf1 Regulation of Gene_expression of Pgr 1 0.24 0.19 0
137 INT315985 Rhd Positive_regulation of Igf1 1 0.07 0.25 0
138 INT295127 Proc Regulation of Igf1 1 0.00 0.48 0
139 INT74024 Igf1 Positive_regulation of Transcription of Penk 1 0.67 0.11 0
140 INT173768 Gh1 Regulation of Igf1 1 0.04 0.13 0
141 INT284369 Igf1 Regulation of VEGFA 1 0.27 0.05 0
142 INT80909 Binding of TNC and TNNC1 1 0.12 0.07 0
143 INT269769 Gh Regulation of Gene_expression of Igf1 1 0.04 0.98 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for interstitial matrix. They are ordered first by their pain relevance and then by number of times they were reported in interstitial matrix. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT14559 Gene_expression of Igf1 254 0.78 112 34.17
2 INT8915 Gene_expression of Igf1 199 0.78 78.58 32.51
3 INT14556 Positive_regulation of Igf1 105 0.69 52.21 24.04
4 INT65263 Positive_regulation of Gene_expression of Igf1 61 0.69 25.69 14.49
5 INT20632 Gene_expression of TNC 72 0.78 30.43 13.16
6 INT17539 Positive_regulation of Igf1 68 0.69 28.47 13.02
7 INT32054 Gene_expression of Tnc 14 0.59 9.36 12.22
8 INT46695 Positive_regulation of TNC 28 0.67 17.06 12.04
9 INT79166 Regulation of TNC 12 0.44 9.42 8.13
10 INT3803 Negative_regulation of Igf1 45 0.58 15.95 7.98
11 INT79168 Binding of TNC 39 0.47 16.51 7.55
12 INT142344 Transcription of Igf1 22 0.69 7.55 6.77
13 INT14560 Regulation of Igf1 41 0.59 19.59 6.3
14 INT9494 Positive_regulation of Gene_expression of Igf1 34 0.67 17.77 6.26
15 INT9495 Negative_regulation of Gene_expression of Igf1 31 0.59 11.87 6.1
16 INT9321 Transcription of Igf1 25 0.69 10.2 6.08
17 INT8916 Regulation of Igf1 45 0.60 13.06 5.81
18 INT151032 Localization of Igf1 49 0.76 26.32 5.71
19 INT4938 Localization of Tnc 5 0.65 1.73 5.64
20 INT79194 Positive_regulation of Tnc 5 0.41 2.25 4.69
21 INT14831 Negative_regulation of TNC 18 0.50 8.71 4.61
22 INT14557 Negative_regulation of Igf1 96 0.59 54.83 4.45
23 INT68369 Transcription of TNC 13 0.72 8.69 4.42
24 INT49360 Localization of Igf1 22 0.76 6.96 4.26
25 INT32053 Positive_regulation of Gene_expression of Tnc 5 0.45 3.4 4.13
26 INT142174 Regulation of Gene_expression of Igf1 28 0.60 11.86 3.77
27 INT105537 Regulation of Gene_expression of Igf1 15 0.58 6.97 3.23
28 INT78190 Gene_expression of Tnc 10 0.75 21.23 2.91
29 INT139735 Positive_regulation of Transcription of Igf1 4 0.53 1.93 2.49
30 INT4939 Negative_regulation of Tnc 2 0.32 0.79 2.46
31 INT66544 Binding of Igf1 23 0.46 8.33 2.44
32 INT195080 Positive_regulation of Tnc 4 0.45 26.67 2.34
33 INT156666 Positive_regulation of Localization of Igf1 11 0.62 6.94 1.95
34 INT142341 Positive_regulation of Transcription of Igf1 8 0.49 2.44 1.95
35 INT161432 Negative_regulation of Gene_expression of Tnc 2 0.38 1.44 1.93
36 INT105148 Positive_regulation of Gene_expression of TNC 6 0.50 6.45 1.8
37 INT49361 Regulation of Positive_regulation of Igf1 2 0.45 2.15 1.49
38 INT240359 Binding of Tnc 2 0.35 11.67 1.48
39 INT79167 Localization of TNC 8 0.78 4.15 1.44
40 INT135959 Negative_regulation of Gene_expression of Igf1 37 0.56 21.16 1.41
41 INT351254 Regulation of Regulation of TNC 1 0.14 0.55 1.4
42 INT90491 Binding of Igf1 25 0.44 9.75 1.36
43 INT142616 Negative_regulation of Positive_regulation of Igf1 5 0.43 1.56 1.16
44 INT218776 Negative_regulation of Ccdc80 2 0.02 0.97 0.99
45 INT299153 Negative_regulation of Tnc 2 0.42 8.14 0.98
46 INT167465 Regulation of Ccdc80 1 0.01 0.87 0.94
47 INT20624 Regulation of Gene_expression of TNC 5 0.60 2.49 0.87
48 INT224958 Negative_regulation of Transcription of Igf1 5 0.56 1.37 0.81
49 INT124873 Positive_regulation of Positive_regulation of Tnc 1 0.35 0.14 0.75
50 INT106343 Positive_regulation of Positive_regulation of Igf1 2 0.69 1.45 0.59
51 INT220365 Negative_regulation of Transcription of Igf1 3 0.45 1.28 0.56
52 INT49362 Positive_regulation of Localization of Igf1 4 0.65 2.26 0.53
53 INT354785 Regulation of Binding of Tnc 1 0.06 1.63 0.53
54 INT90353 Regulation of Gene_expression of Tnc 1 0.26 0.22 0.52
55 INT124872 Regulation of Localization of Tnc 1 0.31 0.1 0.52
56 INT185513 Phosphorylation of Igf1 3 0.67 0.46 0.5
57 INT225665 Positive_regulation of Binding of TNC 1 0.38 0.74 0.49
58 INT261817 Protein_catabolism of Ccdc80 1 0.02 0.86 0.45
59 INT140942 Regulation of Transcription of Igf1 3 0.32 1.37 0.43
60 INT147227 Positive_regulation of Ccdc80 1 0.01 0.08 0.38
61 INT22786 Regulation of Tnc 1 0.23 0.18 0.37
62 INT261774 Positive_regulation of Phosphorylation of Igf1 1 0.08 0.09 0.36
63 INT200198 Regulation of Localization of Igf1 6 0.58 4.51 0.34
64 INT302895 Gene_expression of Nav2 1 0.78 3.4 0.34
65 INT105968 Positive_regulation of Binding of Igf1 2 0.20 0.56 0.32
66 INT78193 Regulation of Tnc 2 0.19 0.31 0.31
67 INT354784 Positive_regulation of Positive_regulation of Tnc 1 0.07 1.14 0.3
68 INT200200 Positive_regulation of Negative_regulation of Igf1 3 0.47 2.33 0.22
69 INT173753 Positive_regulation of Negative_regulation of Igf1 1 0.34 0.47 0.19
70 INT231055 Regulation of Localization of Igf1 1 0.15 0 0.17
71 INT198357 Negative_regulation of Localization of Igf1 1 0.03 0.51 0.17
72 INT286068 Positive_regulation of Positive_regulation of Igf1 2 0.40 1.03 0.16
73 INT178199 Localization of Tnc 2 0.78 5.29 0.16
74 INT302903 Negative_regulation of Nav2 1 0.43 0.9 0.15
75 INT185511 Regulation of Phosphorylation of Igf1 1 0.37 0 0.14
76 INT175970 Negative_regulation of Phosphorylation of Igf1 2 0.39 2.1 0.13
77 INT285632 Regulation of Binding of Igf1 1 0.37 0.55 0.13
78 INT175968 Phosphorylation of Igf1 6 0.74 2.54 0.1
79 INT302900 Negative_regulation of Gene_expression of Nav2 1 0.43 0.26 0.09
80 INT302896 Positive_regulation of Nav2 1 0.47 0.62 0.08
81 INT175972 Regulation of Phosphorylation of Igf1 1 0.41 0.95 0.07
82 INT148819 Positive_regulation of Positive_regulation of TNC 4 0.45 0.53 0.05
83 INT286067 Regulation of Regulation of Igf1 2 0.37 0.21 0.05
84 INT302902 Binding of Nav2 1 0.48 0.29 0.05
85 INT302907 Transcription of Nav2 1 0.72 0.85 0.03
86 INT176243 Positive_regulation of Binding of Igf1 3 0.07 1.36 0
87 INT185508 Protein_catabolism of Igf1 2 0.84 0 0
88 INT142343 Negative_regulation of Regulation of Igf1 2 0.41 0.35 0
89 INT216450 Regulation of Transcription of Igf1 1 0.26 0 0
90 INT112084 Negative_regulation of Positive_regulation of Igf1 1 0.31 0.11 0
91 INT210949 Positive_regulation of Negative_regulation of TNC 1 0.21 0.66 0
92 INT295565 Positive_regulation of Phosphorylation of Igf1 1 0.19 0.17 0
93 INT302904 Regulation of Gene_expression of Nav2 1 0.39 0 0
94 INT269768 Negative_regulation of Negative_regulation of Igf1 1 0.08 0.96 0
95 INT308786 Negative_regulation of Gene_expression of TNC 1 0.02 0.08 0
96 INT302894 Localization of Nav2 1 0.75 0.23 0
97 INT112083 Negative_regulation of Negative_regulation of Igf1 1 0.31 0.22 0
98 INT302897 Regulation of Nav2 1 0.45 0.15 0
99 INT246771 Negative_regulation of Phosphorylation of Igf1 1 0.09 0.37 0
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