GO:0005624

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Name membrane fraction
Categary Component
Go Slim No
Go Link GO:0005624
Unique Molecular Interactions 8164
Total Molecular Interactions 11021
Total Single Events 107765
Pain Genes Associated 614

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for membrane fraction. They are ordered first by their pain relevance and then by number of times they were reported for membrane fraction. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT259233 Binding of Oprm1 and Flna 1 0.03 0.25 25.89
2 INT221180 Binding of OPRM1 and Flna 1 0.09 0.22 12.65
3 INT21276 Binding of Oprd1 and Penk 9 0.54 1.14 8.28
4 INT11250 Cck Positive_regulation of Gene_expression of Fos 14 0.78 0.08 7.29
5 INT259228 Binding of Oprm1 and Glul 1 0.00 0.08 7.22
6 INT132225 Negative_regulation of Binding of Akt1 and Sh2d6 1 0.10 3.92 7.2
7 INT296275 Binding of Dlg4 and Kcnip3 1 0.39 3.58 5.6
8 INT296484 Binding of Gria2 and GRIP1 1 0.04 4.52 4.59
9 INT186566 Hpcl1 Positive_regulation of Fos 1 0.17 0.38 4.49
10 INT32444 Binding of Cpe and Pomc 2 0.22 0 4.47
11 INT7022 Drd1a Positive_regulation of Npr1 6 0.05 0.26 4.32
12 INT40114 Binding of OPRD1 and Oprm1 2 0.00 0 4.29
13 INT103724 Oprd1 Positive_regulation of Gtpbp4 3 0.30 0.91 4.18
14 INT259230 Negative_regulation of Binding of Oprm1 and Flna 1 0.02 0 4.15
15 INT136514 Binding of Grm1 and Grm5 4 0.12 1.8 3.9
16 INT113080 Drd1a Positive_regulation of Phosphorylation of Creb1 2 0.27 0.43 3.88
17 INT130625 Prkcg Regulation of Prkaca 1 0.23 1.32 3.87
18 INT317511 Ppp1r9b Regulation of Oprm1 3 0.27 0.33 3.85
19 INT317517 Binding of Nos1 and Oprm1 1 0.17 0.22 3.85
20 INT220623 Binding of Stat1 and Bace1 11 0.25 10.33 3.81
21 INT249566 Binding of Oprd1 and Psmd1 1 0.01 0.82 3.8
22 INT11252 Cck Positive_regulation of Fos 6 0.78 0 3.79
23 INT134284 Binding of OPRM1 and PLD2 1 0.52 0 3.72
24 INT322411 Hist1h1t Positive_regulation of Positive_regulation of OPRM1 1 0.00 1.25 3.63
25 INT115690 Negative_regulation of Prkcg Negative_regulation of Gene_expression of Fos 1 0.47 0.72 3.63
26 INT132231 Negative_regulation of Binding of Akt1 and Pik3cg 1 0.34 1.96 3.6
27 INT18026 Binding of Oprd1 and Oprm1 4 0.40 0.83 3.53
28 INT17317 Binding of Jun and Fos 7 0.42 1.03 3.5
29 INT302118 Binding of Oprm1 and Ppp1r9b 2 0.24 0.26 3.45
30 INT195931 Binding of OPRM1 and Trpv1 1 0.07 0.87 3.43
31 INT73071 Binding of Cpe and Insrr 3 0.01 0.33 3.38
32 INT56458 Binding of GPM6A and IGHG3 4 0.02 0 3.31
33 INT137918 Oprm1 Positive_regulation of Pdgfrb 1 0.41 0 3.31
34 INT276676 Prkcg Regulation of Nav1 1 0.30 0.82 3.29
35 INT108810 Esr1 Positive_regulation of Binding of Oprm1 1 0.51 1.79 3.22
36 INT270949 Binding of Slc6a3 and Cpe 1 0.28 0.25 3.19
37 INT251146 Binding of Grin1 and Dlg2 1 0.36 1.95 3.16
38 INT317522 Akt1 Positive_regulation of Phosphorylation of Nos1 1 0.43 0.4 3.13
39 INT161164 Prkcg Regulation of Phosphorylation of Creb1 3 0.41 0.62 3.11
40 INT101408 Binding of Grin1 and Olr1469 1 0.03 0.86 3.1
41 INT101407 Binding of Grin1 and Spr 1 0.14 0.86 3.09
42 INT276679 Prkcg Positive_regulation of Positive_regulation of Nkx1-1 1 0.07 0.94 3.08
43 INT317563 Binding of Hint1 and Oprm1 1 0.20 0.25 3.03
44 INT106338 Positive_regulation of Tacr1 Positive_regulation of Localization of Abat 5 0.34 0 3.01
45 INT102284 Binding of Grin1 and Grin2a 5 0.27 1.79 3.01
46 INT106837 Binding of Oprm1 and Arrb2 3 0.32 0.83 3.01
47 INT118158 Binding of Prkca and Prkcz 1 0.07 1.14 2.98
48 INT324927 Syt17 Positive_regulation of Bdkrb1 1 0.04 4.29 2.96
49 INT113234 Binding of Pax3 and Tacr1 3 0.12 1.54 2.93
50 INT42728 Binding of PRLR and Cpe 1 0.00 0 2.91
51 INT156381 Binding of Grin1 and Dlg4 1 0.39 0.86 2.9
52 INT264929 Binding of Cnr1 and Gnaz 1 0.18 1.71 2.89
53 INT298456 Prkaca Positive_regulation of Phosphorylation of Adarb1 1 0.00 1.86 2.85
54 INT351349 Prkcg Positive_regulation of Binding of Lpar1 1 0.15 2 2.82
55 INT170367 Binding of Grin1 and Grin2a 5 0.23 1.72 2.79
56 INT168758 Hist1h1t Positive_regulation of Phosphorylation of Akt1 2 0.02 0.44 2.79
57 INT137230 Trh Regulation of Gene_expression of Oprd1 1 0.01 1.62 2.75
58 INT317551 Binding of Akt1 and Oprm1 1 0.19 0.21 2.74
59 INT127621 Bst1 Regulation of Positive_regulation of Fos 1 0.26 0 2.73
60 INT140347 Binding of ATP1A2 and Cacna1a 1 0.11 2.88 2.73
61 INT318474 Positive_regulation of OPRM1 Positive_regulation of Localization of CA2 1 0.17 0.55 2.7
62 INT103669 Hps4 Positive_regulation of Mors1 1 0.01 0 2.7
63 INT114134 Penk Positive_regulation of Oprm1 2 0.24 1.48 2.68
64 INT259231 Binding of Oprm1 and Ppp1r9b 1 0.01 0 2.67
65 INT91350 Binding of Pla2g4a and RYBP 1 0.00 1.15 2.65
66 INT326585 Binding of GYPA and SLC6A3 1 0.13 0.86 2.64
67 INT351444 Grin1 Positive_regulation of Gria2 1 0.22 1.5 2.64
68 INT167769 Prkca Positive_regulation of Positive_regulation of Sigmar1 1 0.38 0.86 2.63
69 INT251150 Binding of Nos1 and Dlg2 1 0.30 1.98 2.62
70 INT121742 Prkcg Positive_regulation of Ephb1 3 0.49 0.99 2.6
71 INT121698 HRAS Negative_regulation of Gene_expression of MMP3 1 0.06 0.5 2.6
72 INT150596 Binding of Oprd1 and Oprk1 1 0.08 0.14 2.59
73 INT210696 Trpv1 Regulation of Slc12a2 1 0.25 1.97 2.58
74 INT42727 Binding of Oprm1 and Trim13 1 0.14 0 2.54
75 INT69665 Binding of Oprd1 and Pnoc 5 0.35 0.4 2.5
76 INT249567 Positive_regulation of Binding of Oprd1 and Psmd1 1 0.01 0.66 2.5
77 INT317528 Ppp1r9b Regulation of Grin1 1 0.18 0.2 2.48
78 INT314141 Binding of Tacr3 and SFTPA1 1 0.00 3.02 2.48
79 INT14687 Binding of Penk and Ppt1 1 0.41 0 2.46
80 INT156799 Gria1 Regulation of Grm8 1 0.11 1.29 2.45
81 INT147659 Prkce Positive_regulation of TRPV1 1 0.04 1.42 2.43
82 INT251147 Binding of Grin2b and Dlg2 1 0.33 2.75 2.43
83 INT56726 Cpe Negative_regulation of Pomc 1 0.07 0 2.41
84 INT317526 Binding of Hint1 and Gipc1 1 0.00 0.25 2.38
85 INT107578 Kitl Negative_regulation of Grin2b 1 0.12 2.05 2.36
86 INT121746 Prkaca Positive_regulation of Ephb1 2 0.23 0.92 2.35
87 INT96461 Pnoc Positive_regulation of Oprm1 1 0.09 0.73 2.34
88 INT88730 Binding of OPRM1 and Mop3 1 0.00 0 2.34
89 INT121726 Ngf Positive_regulation of Phosphorylation of Akt1 1 0.37 1.4 2.34
90 INT154226 Positive_regulation of Oprk1 Negative_regulation of Negative_regulation of Oprm1 1 0.28 0.07 2.32
91 INT322410 Hist1h1t Positive_regulation of Phosphorylation of OPRM1 1 0.00 0.08 2.31
92 INT106558 Binding of Ntrk2 and Ntrk3 3 0.52 2.51 2.28
93 INT317524 Binding of Camk2a and Grin1 1 0.17 0.06 2.21
94 INT114432 Oprl1 Positive_regulation of Akt1 1 0.18 0.08 2.2
95 INT146930 CAP1 Regulation of ABCB1 1 0.29 0.3 2.19
96 INT146520 Tmem132a Regulation of Gene_expression of Fos 1 0.69 0.5 2.18
97 INT5486 Oprd1 Regulation of Cck 1 0.21 0 2.16
98 INT134583 Arrb2 Regulation of Oprm1 1 0.41 1.23 2.15
99 INT142527 Binding of Slc1a2 and Slc1a3 2 0.31 0.12 2.13
100 INT45376 Binding of Cpe and Mme 1 0.07 0.32 2.13
101 INT318473 Positive_regulation of OPRM1 Positive_regulation of CA2 1 0.17 0.46 2.13
102 INT251145 Binding of Grin2a and Dlg2 1 0.31 2.3 2.11
103 INT83425 Binding of CD40LG and IGHG3 11 0.21 4.56 2.09
104 INT85041 Binding of IGHG3 and MAX 1 0.00 0 2.09
105 INT51198 Positive_regulation of Binding of OPRM1 and PDYN 2 0.18 0.3 2.08
106 INT51199 Binding of OPRM1 and PDYN 2 0.13 0.3 2.08
107 INT221181 Binding of GOPC and Flna 1 0.03 0.06 2.08
108 INT64750 Binding of Oprm1 and Pck1 2 0.41 0.51 2.07
109 INT114927 Positive_regulation of Binding of Oprm1 and Creb1 1 0.17 0.28 2.07
110 INT281084 Prkaca Positive_regulation of Mapk1 2 0.25 0 2.06
111 INT114923 Binding of Oprm1 and Creb1 1 0.16 0.28 2.06
112 INT134215 CRH Positive_regulation of ENG 1 0.13 1.22 2.06
113 INT117821 Binding of Tacr1 and Cd4 1 0.34 0.86 2.02
114 INT121216 Prkca Regulation of Positive_regulation of Oprd1 1 0.02 0.32 2.02
115 INT144115 Positive_regulation of Grm5 Positive_regulation of Prkcg 1 0.41 0 2.01
116 INT349608 Binding of DIO2 and LMOD1 1 0.23 0.41 2.01
117 INT117794 Hpcl1 Positive_regulation of Gene_expression of Fos 3 0.17 0.15 1.98
118 INT281381 FSCN1 Positive_regulation of Gene_expression of Gfap 1 0.06 1.13 1.98
119 INT137917 Oprm1 Positive_regulation of Kdr 1 0.43 0 1.98
120 INT317540 Camk2a Negative_regulation of Oprm1 1 0.19 0 1.98
121 INT69556 Slc7a11 Regulation of Cpe 2 0.06 0.46 1.95
122 INT146099 Binding of Oprm1 and Rgs9 1 0.48 0 1.95
123 INT73072 Negative_regulation of Binding of Cpe and Insrr 1 0.00 0 1.94
124 INT156509 Il6 Regulation of Positive_regulation of Grin1 1 0.28 1.93 1.93
125 INT68272 Binding of Oprd1 and G2e3 1 0.00 0.11 1.93
126 INT107738 Binding of Pld2 and Oprm1 1 0.23 0 1.93
127 INT65025 Binding of Oprm1 and Hps4 1 0.01 0 1.93
128 INT104855 Prkaca Regulation of TRPV1 3 0.06 1.52 1.92
129 INT125348 Decr1 Regulation of Gene_expression of Fos 1 0.00 0.1 1.92
130 INT264928 Binding of Cnr1 and Hrh1 1 0.01 1.61 1.92
131 INT112514 Binding of Prkaca and Trib3 1 0.03 1.18 1.9
132 INT186435 Prkcg Regulation of Creb1 1 0.44 0.45 1.9
133 INT169498 Binding of Oprm1 and Mirlet7a-1 1 0.32 0 1.9
134 INT186432 Prkaca Regulation of Creb1 1 0.14 0.45 1.9
135 INT113572 Binding of DMRT1 and OPRM1 1 0.01 0 1.9
136 INT169570 Binding of ROS1 and TRPV1 3 0.33 3.07 1.89
137 INT134686 FSCN1 Positive_regulation of Gfap 1 0.00 0.71 1.89
138 INT153582 Binding of Oprm1 and Hint1 1 0.01 0 1.87
139 INT169346 Nxn Negative_regulation of Dynll1 1 0.06 1.22 1.87
140 INT135582 Prok2 Positive_regulation of Localization of Prkce 1 0.06 1.02 1.87
141 INT211747 Negative_regulation of Binding of Oprm1 and Mors1 1 0.09 0 1.86
142 INT112517 Binding of Ephb1 and Prkaca 3 0.18 0.58 1.85
143 INT29996 Binding of Oprm1 and Penk 2 0.36 0.4 1.85
144 INT50993 Il1b Positive_regulation of Fos 2 0.40 0.43 1.84
145 INT199486 Oprm1 Regulation of Gene_expression of Oprd1 1 0.02 0.49 1.84
146 INT349658 Nos2 Regulation of Gene_expression of Nos1 1 0.63 2.86 1.84
147 INT352464 Gse1 Positive_regulation of Gene_expression of Slc1a3 1 0.05 1.55 1.83
148 INT43447 Binding of H3 and Hps4 1 0.07 0 1.82
149 INT276669 Negative_regulation of Prkcg Regulation of Nav1 1 0.21 0.68 1.82
150 INT119917 Zfp821 Positive_regulation of Positive_regulation of Oprd1 1 0.01 0 1.82
151 INT120732 Prkcg Positive_regulation of Phosphorylation of Grin1 2 0.48 1.04 1.81
152 INT7023 Negative_regulation of Drd1a Positive_regulation of Npr1 2 0.05 0.1 1.81
153 INT169502 Mirlet7a-1 Regulation of Oprm1 1 0.53 0 1.81
154 INT272616 Positive_regulation of Binding of Grin1 and Grin2a 2 0.30 1.36 1.8
155 INT199287 TNF Positive_regulation of Transcription of Oprm1 2 0.02 1.86 1.8
156 INT112526 D2Mit212 Negative_regulation of Gene_expression of Fos 1 0.03 0.28 1.8
157 INT121218 Arrb2 Regulation of Negative_regulation of Prkca 1 0.17 0.23 1.8
158 INT70225 oh Regulation of Oprd1 1 0.20 0.13 1.8
159 INT132229 Binding of Akt1 and Sh2d6 1 0.09 0.98 1.8
160 INT100771 Binding of Itga1 and Vcam1 3 0.11 3.91 1.79
161 INT66504 Binding of Agt and Agtr1a 8 0.39 3.78 1.78
162 INT168925 Binding of Oprm1 and Imraq2 1 0.04 0.13 1.78
163 INT168924 Positive_regulation of Binding of Oprm1 and Imraq2 1 0.06 0.13 1.78
164 INT211746 Binding of Oprm1 and Mors1 1 0.08 0 1.78
165 INT31445 ENG Positive_regulation of Localization of Prl 4 0.01 0 1.77
166 INT167319 Binding of OPRM1 and PCSK2 1 0.22 0.63 1.77
167 INT167320 Binding of CPE and OPRM1 1 0.14 0.63 1.77
168 INT336556 SLC6A3 Positive_regulation of Gene_expression of GOPC 1 0.08 1.87 1.76
169 INT167321 Binding of ENG and OPRM1 1 0.27 0.63 1.76
170 INT146512 Tmem132a Negative_regulation of Gene_expression of Fos 1 0.23 0 1.76
171 INT332773 Positive_regulation of Prkaca Positive_regulation of Phosphorylation of Grin1 1 0.04 0.73 1.75
172 INT190981 Binding of Npy and Scn2a1 1 0.10 0 1.75
173 INT129953 Oprd1 Regulation of Cspg5 1 0.17 0.15 1.74
174 INT167765 Prkca Positive_regulation of Sigmar1 1 0.41 0.63 1.74
175 INT157524 Binding of GRM5 and OPRM1 1 0.36 0 1.74
176 INT37840 Binding of Cyp27b1 and Oprd1 1 0.01 0 1.73
177 INT346217 Braf Positive_regulation of Phosphorylation of Map2k1 1 0.22 3.23 1.72
178 INT185143 Elane Positive_regulation of Pik3r1 1 0.01 0 1.72
179 INT139156 Binding of Gria1 and Gria2 1 0.23 0.64 1.72
180 INT6407 Binding of Lama5 and Oprm1 1 0.02 0.08 1.72
181 INT296280 Binding of Car2 and Dlg4 1 0.19 0.45 1.71
182 INT18786 Binding of Adra2a and Nisch 2 0.19 0 1.7
183 INT169464 Akt1 Positive_regulation of Egfr 1 0.28 1.63 1.7
184 INT200335 Binding of Oprm1 and Rest 1 0.40 0.07 1.7
185 INT134363 Prkcg Regulation of ADCY2 1 0.00 0.14 1.7
186 INT70148 Drd1a Positive_regulation of Localization of Acot1 1 0.14 0 1.7
187 INT199503 ENG Positive_regulation of Oprk1 1 0.01 0.87 1.69
188 INT160304 Npy Regulation of Gene_expression of Fos 3 0.67 1.43 1.68
189 INT45306 Pomc Positive_regulation of ENG 2 0.07 1.11 1.68
190 INT199504 ENG Positive_regulation of Oprm1 1 0.01 0.87 1.68
191 INT105917 Binding of SLC22A6 and SLC22A8 2 0.31 0.34 1.67
192 INT276672 Binding of Prkcg and Nav1 1 0.16 0.18 1.67
193 INT139433 Binding of Prkaca and Prkca 1 0.37 0.13 1.67
194 INT276680 Binding of Prkcg and Nkx1-1 1 0.05 0.18 1.66
195 INT122428 Binding of Ighm and Prkci 1 0.00 0 1.66
196 INT149680 Binding of Parp1 and Oprm1 1 0.53 0 1.66
197 INT93470 Notch1 Positive_regulation of Localization of Prkcg 2 0.09 0.31 1.65
198 INT96296 Oprm1 Negative_regulation of Npr1 2 0.05 0.32 1.65
199 INT83093 IL1B Positive_regulation of BDKRB1 1 0.51 0.44 1.65
200 INT322412 PPBP Negative_regulation of Phosphorylation of Akt1 1 0.01 0 1.65

Single Events

The table below shows the top 100 pain related interactions that have been reported for membrane fraction. They are ordered first by their pain relevance and then by number of times they were reported in membrane fraction. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT5200 Gene_expression of Fos 3083 0.78 894.43 1639.02
2 INT5202 Positive_regulation of Gene_expression of Fos 1163 0.70 319.28 684
3 INT5228 Positive_regulation of Fos 934 0.70 209.8 503.87
4 INT5895 Gene_expression of Oprm1 525 0.78 120.67 407.29
5 INT6056 Negative_regulation of Gene_expression of Fos 601 0.59 193.05 386.84
6 INT5660 Binding of Oprd1 477 0.48 71.86 342.06
7 INT5979 Gene_expression of Oprd1 428 0.78 75.64 320.32
8 INT5540 Positive_regulation of Oprm1 344 0.70 76.77 319.71
9 INT4941 Positive_regulation of Oprd1 345 0.70 74.26 304.41
10 INT9131 Positive_regulation of Prkcg 431 0.70 130.8 302.41
11 INT11624 Gene_expression of OPRM1 445 0.78 72.36 294.36
12 INT5379 Gene_expression of Fos 656 0.78 255.5 292.54
13 INT5591 Regulation of Gene_expression of Fos 425 0.62 129.06 265.78
14 INT5501 Regulation of Oprd1 283 0.62 55.1 249.9
15 INT6406 Binding of Oprm1 280 0.48 40.54 226.26
16 INT6293 Gene_expression of Oprm1 312 0.78 48.73 215.61
17 INT4893 Gene_expression of Tacr1 366 0.78 129.67 213.92
18 INT9132 Negative_regulation of Prkcg 279 0.59 88.05 203.47
19 INT12602 Negative_regulation of Oprm1 190 0.59 36.11 177.85
20 INT26472 Regulation of Oprm1 191 0.62 35.84 173.1
21 INT5930 Positive_regulation of Oprm1 221 0.70 31.19 172.93
22 INT4937 Negative_regulation of Oprd1 224 0.59 44.51 171.11
23 INT4768 Positive_regulation of OPRM1 212 0.70 31.09 164.28
24 INT6042 Binding of Oprm1 248 0.48 31.77 154.34
25 INT120811 Gene_expression of Gopc 1174 0.59 428.49 150.55
26 INT49134 Gene_expression of Grin1 270 0.78 84.78 148.61
27 INT90910 Phosphorylation of Grin1 150 0.82 68.23 139.24
28 INT5061 Negative_regulation of Mme 306 0.59 51.97 136.9
29 INT4658 Binding of OPRM1 188 0.48 25.96 136.24
30 INT5380 Positive_regulation of Gene_expression of Fos 243 0.70 105.65 131.05
31 INT64161 Positive_regulation of Prkca 213 0.70 85.06 129.91
32 INT5842 Gene_expression of Gfap 372 0.78 153.71 127.71
33 INT1878 Binding of HLA-B 440 0.48 321.16 127.36
34 INT5931 Regulation of Oprm1 149 0.62 18.15 125.93
35 INT4824 Positive_regulation of Tacr1 169 0.70 66.1 123.46
36 INT7341 Positive_regulation of Grin1 169 0.70 65.86 118.38
37 INT47243 Gene_expression of Prkcg 195 0.78 58.05 108.44
38 INT4936 Localization of Tacr1 125 0.80 35.7 107.7
39 INT49171 Gene_expression of Nos1 241 0.78 140.7 104.76
40 INT12569 Localization of Oprd1 94 0.81 23.81 104.56
41 INT69440 Gene_expression of ROS1 752 0.78 477.64 103.83
42 INT90091 Gene_expression of GOPC 967 0.67 366.22 103.6
43 INT5906 Negative_regulation of Oprm1 125 0.59 19.58 101.57
44 INT74826 Gene_expression of Slc1a2 131 0.78 61.83 100.84
45 INT5587 Regulation of Fos 191 0.62 40.81 99.7
46 INT52651 Positive_regulation of Prkaca 136 0.67 40.82 99.16
47 INT65500 Gene_expression of App 605 0.78 429.94 98.31
48 INT7944 Positive_regulation of Fos 193 0.70 60.69 98.31
49 INT74058 Gene_expression of Nos1 260 0.78 80.04 95.71
50 INT104000 Phosphorylation of Grin2b 73 0.82 48.34 93.48
51 INT1639 Negative_regulation of OPRM1 107 0.59 13.86 90.37
52 INT12763 Phosphorylation of Prkcg 167 0.82 38.91 89.63
53 INT64158 Negative_regulation of Prkca 121 0.59 29.8 88.66
54 INT15898 Positive_regulation of Prkaca 199 0.70 50.89 87.54
55 INT4857 Regulation of Tacr1 115 0.62 39.01 84.52
56 INT5590 Negative_regulation of Fos 144 0.59 40.94 81.98
57 INT92518 Gene_expression of Grin2b 131 0.78 65.52 80.91
58 INT7528 Regulation of OPRM1 100 0.62 20.63 80.57
59 INT749 Gene_expression of HLA-B 341 0.75 224.12 77.37
60 INT29708 Gene_expression of Gria1 177 0.78 56.36 77.37
61 INT1724 Negative_regulation of ACE 437 0.59 315.64 74.48
62 INT12536 Localization of Prkcg 101 0.80 36.37 73.81
63 INT79506 Gene_expression of Grin2b 122 0.78 43.71 73.42
64 INT49111 Negative_regulation of Prkaca 102 0.59 27.44 71.77
65 INT8962 Gene_expression of Cpe 110 0.71 39.67 71.67
66 INT5843 Positive_regulation of Gfap 184 0.70 108.2 70.21
67 INT53964 Negative_regulation of Prkaca 131 0.58 38.76 69.52
68 INT39777 Regulation of Prkcg 90 0.62 31.52 68.17
69 INT8733 Localization of Oprm1 61 0.75 7.55 64.61
70 INT1169 Negative_regulation of Bche 322 0.59 149.22 61.27
71 INT103924 Positive_regulation of Akt1 359 0.69 158.94 60.34
72 INT79093 Positive_regulation of Nos1 101 0.70 46.89 59.61
73 INT90911 Positive_regulation of Phosphorylation of Grin1 62 0.70 27.45 59.26
74 INT62960 Gene_expression of P2rx2 149 0.77 58.31 59.16
75 INT49170 Negative_regulation of Nos1 116 0.59 60.66 58.87
76 INT8732 Positive_regulation of Gene_expression of Oprm1 76 0.70 22.59 58.83
77 INT169926 Positive_regulation of Gopc 416 0.46 157.8 58.67
78 INT6436 Positive_regulation of Positive_regulation of Fos 101 0.70 18.71 57.96
79 INT7340 Regulation of Grin1 87 0.62 30.37 57.93
80 INT68813 Transcription of Oprm1 93 0.71 20.11 57.65
81 INT5017 Negative_regulation of Tacr1 76 0.58 17 57.07
82 INT6669 Negative_regulation of Positive_regulation of Fos 98 0.59 23.5 56.82
83 INT20266 Positive_regulation of Bdkrb1 60 0.69 63.64 56.59
84 INT64159 Gene_expression of Prkca 90 0.78 34.65 55.97
85 INT8528 Negative_regulation of Gene_expression of Fos 100 0.59 41.15 55.6
86 INT96533 Gene_expression of Slc1a3 72 0.78 26.85 55.31
87 INT82650 Gene_expression of Bcl2 312 0.78 211.71 55.03
88 INT117713 Phosphorylation of Akt1 275 0.82 95.82 54.34
89 INT1486 Negative_regulation of Cpe 85 0.59 28.78 54.08
90 INT6116 Regulation of Gene_expression of Oprd1 69 0.62 16.43 54
91 INT49747 Transcription of Oprm1 68 0.72 9.01 53.78
92 INT7898 Gene_expression of Homer1 123 0.78 31.52 53.67
93 INT8071 Positive_regulation of Gria1 102 0.70 26.61 53.37
94 INT4957 Negative_regulation of Grin1 87 0.59 24.51 53.21
95 INT1487 Regulation of Cpe 68 0.62 10.24 52.91
96 INT69484 Positive_regulation of Gene_expression of OPRM1 75 0.70 12.86 52.27
97 INT10668 Positive_regulation of Gene_expression of Oprd1 61 0.69 15.21 52.12
98 INT5858 Positive_regulation of Drd1a 66 0.69 4.51 51.73
99 INT64110 Positive_regulation of Gene_expression of Nos1 68 0.70 58.11 51.64
100 INT5957 Positive_regulation of Cpe 65 0.69 21.07 51.22
101 INT49028 Positive_regulation of Nos1 102 0.70 34.73 51.05
102 INT74827 Positive_regulation of Gene_expression of Slc1a2 52 0.70 26.54 50.63
103 INT40777 Positive_regulation of Akt1 163 0.69 59.41 49.43
104 INT49520 Gene_expression of P2rx3 121 0.78 61.15 49.24
105 INT32718 Gene_expression of OPRD1 82 0.76 9.43 48.38
106 INT106525 Phosphorylation of Akt1 436 0.82 183.81 47.82
107 INT51627 Gene_expression of Grin2a 82 0.76 25.09 47.6
108 INT62521 Phosphorylation of Oprm1 44 0.82 2.66 47.45
109 INT57021 Positive_regulation of Gene_expression of Grin1 62 0.70 24.77 47.31
110 INT6864 Positive_regulation of Gene_expression of Gfap 110 0.70 59.01 47.07
111 INT48718 Positive_regulation of PRKCA 109 0.69 36.16 46.49
112 INT1564 Localization of OPRM1 41 0.80 8.03 44.67
113 INT5214 Localization of Cpe 49 0.73 13.3 44.36
114 INT127013 Negative_regulation of Slc1a3 37 0.54 14.16 43.97
115 INT66383 Phosphorylation of Prkaca 143 0.80 30.85 43.38
116 INT7828 Positive_regulation of Oprd1 55 0.69 14.11 42.86
117 INT157666 Positive_regulation of GOPC 335 0.60 120.19 42.75
118 INT94029 Positive_regulation of Grin2b 58 0.70 24.2 42.52
119 INT170054 Negative_regulation of Gopc 280 0.38 117.89 42.4
120 INT4004 Gene_expression of IGHG3 321 0.71 221.03 42.33
121 INT5539 Negative_regulation of Mme 75 0.59 28.91 41.84
122 INT57442 Phosphorylation of Prkca 98 0.70 31.58 41.04
123 INT69437 Positive_regulation of ROS1 328 0.58 222.83 40.56
124 INT122953 Gene_expression of COMT 65 0.77 25.84 40.49
125 INT49643 Gene_expression of Bdkrb1 39 0.78 46.49 40.21
126 INT92517 Gene_expression of Grin1 105 0.78 29.53 39.43
127 INT47939 Gene_expression of Selp 171 0.76 87.54 39.03
128 INT173693 Localization of Gopc 249 0.65 70.49 38.81
129 INT4925 Binding of Tacr1 57 0.48 17.39 38.38
130 INT92515 Gene_expression of Grin2a 84 0.76 26.68 38.37
131 INT65125 Gene_expression of Tacr1 81 0.77 23.9 38.35
132 INT77307 Gene_expression of Bcl2 399 0.77 319.77 38
133 INT88081 Negative_regulation of Gene_expression of Oprm1 45 0.59 16.56 37.5
134 INT82054 Positive_regulation of Grin2b 56 0.70 17.45 37.14
135 INT11246 Binding of Grin1 65 0.48 14.53 36.93
136 INT64558 Negative_regulation of Nos1 88 0.58 26.76 36.78
137 INT6067 Positive_regulation of Positive_regulation of Oprd1 37 0.69 6.56 36.58
138 INT48959 Positive_regulation of Positive_regulation of Prkcg 52 0.70 16.47 36.49
139 INT14137 Localization of Oprm1 56 0.81 2.88 36.09
140 INT103998 Positive_regulation of Phosphorylation of Grin2b 33 0.69 19.08 36.08
141 INT11292 Gene_expression of Mme 77 0.78 20.98 35.85
142 INT77407 Regulation of Gene_expression of OPRM1 51 0.62 12.58 35.75
143 INT23330 Binding of Chrna7 79 0.48 10.06 35.5
144 INT130479 Phosphorylation of Grin2b 28 0.77 34.82 34.97
145 INT52194 Positive_regulation of Grin1 83 0.69 25.09 34.76
146 INT4892 Positive_regulation of Gene_expression of Tacr1 56 0.69 25.64 34.69
147 INT12765 Positive_regulation of Phosphorylation of Prkcg 59 0.66 20.16 34.67
148 INT7675 Gene_expression of ENG 146 0.77 45.35 34.6
149 INT12161 Positive_regulation of P2rx2 70 0.69 34.22 34.4
150 INT34465 Regulation of Oprd1 34 0.45 7.14 34.29
151 INT74563 Positive_regulation of Gene_expression of ROS1 258 0.61 168.18 34.08
152 INT12537 Positive_regulation of Localization of Prkcg 36 0.70 14.57 33.81
153 INT95789 Positive_regulation of Grm5 42 0.55 20.1 33.72
154 INT11764 Positive_regulation of ENG 78 0.61 27.65 33.69
155 INT2699 Binding of Cpe 40 0.48 7.07 33.64
156 INT48907 Positive_regulation of Gene_expression of Oprm1 53 0.69 8.55 33.52
157 INT84825 Gene_expression of CD36 121 0.78 43.73 33.23
158 INT7133 Negative_regulation of MME 85 0.59 29.22 33.1
159 INT21560 Positive_regulation of Binding of Oprm1 30 0.50 7.16 32.95
160 INT51698 Positive_regulation of Gene_expression of Prkcg 44 0.68 14.02 32.9
161 INT57024 Regulation of Gene_expression of Grin1 32 0.62 9.77 32.6
162 INT89055 Phosphorylation of Prkaca 60 0.61 13.41 32.49
163 INT93451 Positive_regulation of Gene_expression of Grin2b 43 0.70 29.09 31.89
164 INT6053 Transcription of Fos 107 0.72 20.97 31.88
165 INT114881 Gene_expression of Akt1 227 0.78 102.49 31.81
166 INT124860 Gene_expression of Bace1 330 0.78 157.11 31.65
167 INT12397 Gene_expression of Oprd1 53 0.78 9.1 31.31
168 INT29743 Negative_regulation of App 91 0.59 65.56 31.26
169 INT114173 Phosphorylation of Gria1 27 0.82 33.73 31.24
170 INT49001 Regulation of Gria1 51 0.56 18.28 31.22
171 INT64164 Regulation of Prkca 34 0.62 10.44 30.99
172 INT49110 Regulation of Grip2 46 0.61 13.57 30.87
173 INT6058 Localization of Fos 73 0.81 16.7 30.84
174 INT65960 Gene_expression of BCL2 352 0.78 312.03 30.73
175 INT1179 Negative_regulation of Ace 157 0.59 67.03 30.46
176 INT69483 Transcription of OPRM1 45 0.72 7.31 30.22
177 INT9133 Negative_regulation of Positive_regulation of Prkcg 37 0.59 10.95 30.06
178 INT19396 Regulation of Rac1 66 0.53 37.41 30.01
179 INT7664 Negative_regulation of Grip2 68 0.49 10.11 29.93
180 INT64918 Gene_expression of Gria2 108 0.74 29.95 29.67
181 INT16769 Positive_regulation of Positive_regulation of Oprm1 31 0.57 8.29 29.66
182 INT15000 Transcription of Oprd1 32 0.72 5.7 29.22
183 INT106540 Negative_regulation of Phosphorylation of Grin1 15 0.58 9.32 29.13
184 INT49431 Phosphorylation of OPRM1 31 0.82 2.2 29.09
185 INT47712 Positive_regulation of App 135 0.69 101.38 28.94
186 INT15610 Localization of GOPC 223 0.65 68.26 28.7
187 INT104567 Gene_expression of Aqp1 47 0.78 44.84 28.68
188 INT56525 Gene_expression of Gria2 74 0.75 23.15 28.6
189 INT93033 Negative_regulation of Grin2b 48 0.58 20.94 28.54
190 INT52712 Negative_regulation of PRKCA 64 0.57 23.11 28.43
191 INT66200 Gene_expression of Gfap 215 0.78 88.04 28.25
192 INT91775 Gene_expression of Slc6a4 102 0.78 26.45 28.23
193 INT66381 Regulation of Prkaca 40 0.62 13.38 27.96
194 INT5097 Localization of Sstr1 30 0.64 0.38 27.92
195 INT74726 Negative_regulation of Slc6a4 61 0.59 21.01 27.84
196 INT112707 Negative_regulation of Akt1 89 0.59 28.85 27.76
197 INT5771 Binding of Oprd1 37 0.48 2.6 27.54
198 INT9296 Negative_regulation of PLEK 100 0.57 36.65 27.52
199 INT14575 Positive_regulation of Ppt1 60 0.70 9.97 27.4
200 INT10799 Localization of ENG 63 0.78 18.67 27.28
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