GO:0005625

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Name soluble fraction
Categary Component
Go Slim No
Go Link GO:0005625
Unique Molecular Interactions 5911
Total Molecular Interactions 8008
Total Single Events 73761
Pain Genes Associated 523

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for soluble fraction. They are ordered first by their pain relevance and then by number of times they were reported for soluble fraction. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT324068 Binding of GCH1 and SNRNP70 1 0.01 28.19 40.6
2 INT106676 Binding of Trpv1 and Phax 18 0.34 4.19 12.36
3 INT259228 Binding of Oprm1 and Glul 1 0.00 0.08 7.22
4 INT132225 Negative_regulation of Binding of Akt1 and Sh2d6 1 0.10 3.92 7.2
5 INT227157 Binding of PEBP1 and Gpm6a 1 0.00 1.28 5.52
6 INT128296 Negative_regulation of IL1B Positive_regulation of Insr 1 0.10 1.36 4.52
7 INT128295 IL1B Positive_regulation of Insr 1 0.11 1.36 4.5
8 INT32444 Binding of Cpe and Pomc 2 0.22 0 4.47
9 INT30423 Penk Regulation of Localization of Ins1 4 0.26 0.77 4.42
10 INT111758 Binding of Drd2 and Insrr 1 0.01 0.94 4.33
11 INT259209 Binding of Glul and Flna 1 0.03 0 4.2
12 INT64756 oh Negative_regulation of Gpi1 1 0.03 0 4.09
13 INT101942 Binding of CD40 and CD40LG 16 0.23 15.24 4.01
14 INT130625 Prkcg Regulation of Prkaca 1 0.23 1.32 3.87
15 INT317517 Binding of Nos1 and Oprm1 1 0.17 0.22 3.85
16 INT143946 Binding of Pebp1 and Mastl 1 0.00 2.04 3.82
17 INT181455 Binding of Ccr5 and Ccl5 11 0.39 12.13 3.66
18 INT132231 Negative_regulation of Binding of Akt1 and Pik3cg 1 0.34 1.96 3.6
19 INT155891 Nps Negative_regulation of Positive_regulation of Casp3 1 0.27 0.17 3.48
20 INT108473 Binding of ADCYAP1 and PNOC 1 0.32 0.64 3.41
21 INT73071 Binding of Cpe and Insrr 3 0.01 0.33 3.38
22 INT24388 CRH Positive_regulation of Localization of POMC 8 0.51 5.67 3.35
23 INT128293 Negative_regulation of Aldh1a1 Positive_regulation of Insr 1 0.00 0.99 3.34
24 INT128292 Nts Positive_regulation of Insr 1 0.03 0.99 3.34
25 INT128291 Vom1r68 Positive_regulation of Insr 1 0.00 0.99 3.33
26 INT128294 Aldh1a1 Positive_regulation of Insr 1 0.00 0.99 3.33
27 INT182704 Binding of NPFF and TP53INP2 1 0.01 0.73 3.28
28 INT189488 Binding of Ccr1 and Ccl5 8 0.40 9.26 3.27
29 INT7190 Syt17 Positive_regulation of Ctsb 1 0.16 0 3.23
30 INT7193 Abl2 Positive_regulation of Ctsb 1 0.21 0 3.21
31 INT270949 Binding of Slc6a3 and Cpe 1 0.28 0.25 3.19
32 INT91271 Mtr Regulation of Gene_expression of Il6 1 0.20 0 3.17
33 INT289979 Binding of Helt and Negative_regulation of Maoa 1 0.00 0.17 3.14
34 INT317522 Akt1 Positive_regulation of Phosphorylation of Nos1 1 0.43 0.4 3.13
35 INT182635 Binding of CCR5 and CCL5 2 0.09 4.19 3
36 INT118158 Binding of Prkca and Prkcz 1 0.07 1.14 2.98
37 INT42728 Binding of PRLR and Cpe 1 0.00 0 2.91
38 INT150632 Ea1 Negative_regulation of Mpo 1 0.17 1.55 2.9
39 INT134212 CRH Regulation of Localization of POMC 1 0.47 2.89 2.9
40 INT318996 Binding of CCR3 and CCL5 1 0.07 3.39 2.9
41 INT111757 Positive_regulation of Binding of Drd2 and Insrr 1 0.02 0.64 2.89
42 INT319003 Binding of CCR1 and CCL5 1 0.08 3.38 2.89
43 INT298456 Prkaca Positive_regulation of Phosphorylation of Adarb1 1 0.00 1.86 2.85
44 INT168758 Hist1h1t Positive_regulation of Phosphorylation of Akt1 2 0.02 0.44 2.79
45 INT317551 Binding of Akt1 and Oprm1 1 0.19 0.21 2.74
46 INT251150 Binding of Nos1 and Dlg2 1 0.30 1.98 2.62
47 INT223866 Ltp Positive_regulation of Positive_regulation of Mapk1 2 0.46 0.75 2.61
48 INT121698 HRAS Negative_regulation of Gene_expression of MMP3 1 0.06 0.5 2.6
49 INT189490 Binding of Ccr3 and Ccl5 1 0.33 8.54 2.6
50 INT67663 Ins1 Positive_regulation of Ntrk2 1 0.00 0.19 2.59
51 INT356289 Binding of Egfr and Egf 1 0.13 3.02 2.52
52 INT130284 Ins1 Negative_regulation of Gene_expression of Npy 1 0.32 0.1 2.47
53 INT149494 PNOC Negative_regulation of Gene_expression of CCL5 1 0.19 0.52 2.46
54 INT56726 Cpe Negative_regulation of Pomc 1 0.07 0 2.41
55 INT317526 Binding of Hint1 and Gipc1 1 0.00 0.25 2.38
56 INT106750 Pes1 Negative_regulation of Positive_regulation of Casp3 3 0.23 0 2.35
57 INT121746 Prkaca Positive_regulation of Ephb1 2 0.23 0.92 2.35
58 INT238914 Positive_regulation of CNR1 Positive_regulation of Phosphorylation of MAPK1 1 0.19 3.22 2.35
59 INT121726 Ngf Positive_regulation of Phosphorylation of Akt1 1 0.37 1.4 2.34
60 INT314205 Ngf Positive_regulation of Phosphorylation of Mapk14 1 0.43 1.24 2.3
61 INT85252 Negative_regulation of Chi3l1 Positive_regulation of Casp3 1 0.01 0 2.26
62 INT7195 Negative_regulation of Syt17 Positive_regulation of Ctsb 1 0.10 0 2.25
63 INT85251 Chi3l1 Positive_regulation of Casp3 1 0.01 0 2.25
64 INT34310 CRH Positive_regulation of POMC 3 0.42 0.62 2.21
65 INT114432 Oprl1 Positive_regulation of Akt1 1 0.18 0.08 2.2
66 INT106753 Pes1 Negative_regulation of Gene_expression of Casp3 2 0.12 0 2.19
67 INT140659 Phax Positive_regulation of Trpv1 3 0.49 0.68 2.18
68 INT12140 Ngf Regulation of Chat 1 0.44 1.67 2.18
69 INT184262 Binding of AGER and HMGB1 1 0.34 4.49 2.17
70 INT250867 Fgf8 Positive_regulation of Protein_catabolism of Ecm1 1 0.06 4.35 2.14
71 INT45376 Binding of Cpe and Mme 1 0.07 0.32 2.13
72 INT83425 Binding of CD40LG and IGHG3 11 0.21 4.56 2.09
73 INT196586 Negative_regulation of Mapk14 Negative_regulation of TNF 2 0.04 2.02 2.08
74 INT64750 Binding of Oprm1 and Pck1 2 0.41 0.51 2.07
75 INT182200 Binding of CXCR5 and CXCL13 1 0.37 2.89 2.07
76 INT281084 Prkaca Positive_regulation of Mapk1 2 0.25 0 2.06
77 INT134215 CRH Positive_regulation of ENG 1 0.13 1.22 2.06
78 INT167530 Phax Regulation of Gene_expression of Trpv1 1 0.16 0.86 2.05
79 INT69556 Slc7a11 Regulation of Cpe 2 0.06 0.46 1.95
80 INT97208 Binding of Gabrg1 and Gabbr1 2 0.07 0.31 1.94
81 INT73072 Negative_regulation of Binding of Cpe and Insrr 1 0.00 0 1.94
82 INT104855 Prkaca Regulation of TRPV1 3 0.06 1.52 1.92
83 INT146587 Npff Negative_regulation of Positive_regulation of Casp3 1 0.05 0.18 1.92
84 INT262558 Phax Positive_regulation of Trpv1 1 0.01 1.26 1.92
85 INT146586 Npff Negative_regulation of Gene_expression of Casp3 1 0.06 0.18 1.92
86 INT14991 SFTPA1 Positive_regulation of Localization of MPO 1 0.11 1.65 1.92
87 INT112514 Binding of Prkaca and Trib3 1 0.03 1.18 1.9
88 INT186432 Prkaca Regulation of Creb1 1 0.14 0.45 1.9
89 INT13940 DNM2 Regulation of Localization of CGA 1 0.11 0 1.86
90 INT112517 Binding of Ephb1 and Prkaca 3 0.18 0.58 1.85
91 INT314210 Ngf Regulation of Phosphorylation of Mapk14 1 0.34 0.85 1.84
92 INT349658 Nos2 Regulation of Gene_expression of Nos1 1 0.63 2.86 1.84
93 INT19496 Pomc Regulation of Localization of Ins1 1 0.55 0.33 1.82
94 INT132229 Binding of Akt1 and Sh2d6 1 0.09 0.98 1.8
95 INT167319 Binding of OPRM1 and PCSK2 1 0.22 0.63 1.77
96 INT162992 Binding of Ephb1 and Ppm1e 1 0.03 0.25 1.77
97 INT332773 Positive_regulation of Prkaca Positive_regulation of Phosphorylation of Grin1 1 0.04 0.73 1.75
98 INT57249 GNRH1 Regulation of Regulation of CGA 1 0.20 0 1.74
99 INT346217 Braf Positive_regulation of Phosphorylation of Map2k1 1 0.22 3.23 1.72
100 INT185143 Elane Positive_regulation of Pik3r1 1 0.01 0 1.72
101 INT169464 Akt1 Positive_regulation of Egfr 1 0.28 1.63 1.7
102 INT157459 Binding of CX3CR1 and CX3CL1 1 0.32 2.12 1.7
103 INT30134 Binding of TPP1 and S100A9 1 0.13 0.74 1.69
104 INT215100 Binding of Hmgb1 and Tlr4 5 0.29 3.21 1.68
105 INT80199 Ngf Regulation of Transcription of Rab38 1 0.01 1.48 1.68
106 INT324067 Regulation of Binding of GCH1 and SNRNP70 1 0.01 0.95 1.67
107 INT150232 Samhd1 Positive_regulation of Gene_expression of TNFSF13B 1 0.01 1.74 1.67
108 INT139433 Binding of Prkaca and Prkca 1 0.37 0.13 1.67
109 INT101926 Binding of Dio1 and Drd2 4 0.28 0.39 1.66
110 INT18520 Adra2c Positive_regulation of Localization of Ins1 3 0.41 0.63 1.66
111 INT122428 Binding of Ighm and Prkci 1 0.00 0 1.66
112 INT236491 GCH1 Regulation of Pain1 1 0.01 0.89 1.65
113 INT278223 Binding of NOS3 and ACSM3 1 0.41 6.32 1.65
114 INT322412 PPBP Negative_regulation of Phosphorylation of Akt1 1 0.01 0 1.65
115 INT24689 Binding of PLAT and Serpine1 1 0.00 3.77 1.64
116 INT122286 Prkaca Negative_regulation of Negative_regulation of Calca 1 0.12 0.54 1.63
117 INT168612 Negative_regulation of Nos1 Negative_regulation of Positive_regulation of Mmp9 1 0.23 0.45 1.62
118 INT247281 GLC1N Negative_regulation of HRAS 1 0.02 1.98 1.62
119 INT215096 Binding of Hmgb1 and Tlr2 9 0.38 11.61 1.61
120 INT168607 Negative_regulation of Nos1 Negative_regulation of Mmp9 1 0.23 0.45 1.61
121 INT288731 Binding of Got1 and Gpt 1 0.23 1.25 1.61
122 INT73116 TYMS Negative_regulation of DNMT3B 1 0.24 0 1.6
123 INT73115 TYMS Negative_regulation of Positive_regulation of DNMT3B 1 0.24 0 1.6
124 INT195930 OPRM1 Regulation of Prkaca 1 0.01 0 1.59
125 INT54601 Binding of Mtor and Ache 1 0.20 0.8 1.58
126 INT158774 Mapk14 Regulation of Il6 1 0.11 0.08 1.57
127 INT26985 Cpe Negative_regulation of Localization of Ins1 1 0.02 0 1.57
128 INT89011 Lep Positive_regulation of Insr 1 0.19 2.41 1.57
129 INT144280 ACP1 Negative_regulation of Phosphorylation of MAPK1 1 0.37 0.78 1.56
130 INT76651 Cpe Positive_regulation of Gene_expression of Il6 1 0.08 0 1.56
131 INT314214 Mapk14 Positive_regulation of Ngf 1 0.43 1.97 1.56
132 INT315284 PRKG1 Positive_regulation of Nos1 1 0.33 0.85 1.56
133 INT106751 Pes1 Negative_regulation of Casp3 2 0.23 0 1.54
134 INT8734 Pebp1 Positive_regulation of Oprd1 1 0.01 0 1.54
135 INT284785 Gch1 Regulation of Bh4p 1 0.00 1.48 1.54
136 INT351366 LPA Positive_regulation of Rab38 1 0.00 0.95 1.53
137 INT182706 NPFF Regulation of Binding of TP53INP2 1 0.01 0.07 1.52
138 INT137657 Gorasp2 Regulation of Binding of Casp3 1 0.09 0 1.52
139 INT260897 CRH Positive_regulation of Localization of IL8 1 0.24 0.09 1.51
140 INT240057 Binding of RHOB and NME8 1 0.41 4.11 1.5
141 INT121741 Prkaca Negative_regulation of Positive_regulation of Creb1 1 0.10 0.2 1.49
142 INT112034 Gabrb3 Positive_regulation of Pik3r1 1 0.08 0.18 1.48
143 INT222185 Binding of Ccr1 and Ccl3 4 0.23 2.7 1.47
144 INT156008 Bcl2 Regulation of Localization of Aifm1 1 0.17 1.92 1.47
145 INT201950 IFNA1 Positive_regulation of Binding of DPP4 1 0.12 2.17 1.47
146 INT201946 IFNA1 Positive_regulation of DPP4 1 0.17 2.16 1.46
147 INT109958 Binding of CRH and HPSE 1 0.10 0.72 1.46
148 INT169800 Negative_regulation of Adrbk1 Positive_regulation of Positive_regulation of Mapk1 1 0.39 1.04 1.45
149 INT111760 Dio1 Positive_regulation of Binding of Cpe 1 0.04 0.34 1.44
150 INT111761 Positive_regulation of Binding of Cpe and Insrr 1 0.01 0.33 1.43
151 INT214372 Ptprq Positive_regulation of Akt1 1 0.04 0.88 1.43
152 INT172203 Binding of Comt and Maoa 1 0.31 0.98 1.43
153 INT236365 Binding of CD40LG and IL6 3 0.20 4.16 1.42
154 INT111756 Dio1 Positive_regulation of Cpe 1 0.04 0.34 1.42
155 INT224404 Binding of GYPC and PYY 1 0.04 1.48 1.42
156 INT111759 Binding of Cpe and Drd2 1 0.01 0.32 1.42
157 INT111762 Positive_regulation of Binding of Cpe and Drd2 1 0.02 0.33 1.42
158 INT261831 Mapk1 Negative_regulation of Hspg2 1 0.00 1.26 1.42
159 INT148450 Gene_expression of Inhbe Positive_regulation of Mapk1 1 0.07 1.35 1.41
160 INT43814 Binding of Cpe and Oprm1 1 0.08 0 1.41
161 INT161670 H2-M3 Positive_regulation of Positive_regulation of Mapk1 1 0.14 0.73 1.41
162 INT128913 Binding of COMT and PENK 1 0.30 0.07 1.41
163 INT214369 Pik3cb Positive_regulation of Akt1 1 0.56 0.87 1.41
164 INT78974 Binding of Prkcg and Prkaca 2 0.31 0.35 1.4
165 INT134764 Ghrl Regulation of Gene_expression of NOS3 1 0.02 2.66 1.4
166 INT240730 Binding of CRYGD and MTRF1 4 0.03 4.18 1.39
167 INT128914 COMT Regulation of OPRM1 1 0.39 0.07 1.39
168 INT262568 Prkaca Regulation of Trpv1 2 0.10 0.65 1.38
169 INT50706 Phax Positive_regulation of Localization of Trib3 1 0.04 0.28 1.38
170 INT56093 FGFR1 Regulation of Gene_expression of SERPINE1 1 0.23 1.71 1.37
171 INT158762 Binding of Vwf and Mthfr 1 0.05 1.85 1.37
172 INT157460 CX3CL1 Regulation of Gene_expression of COL1A1 1 0.11 1.57 1.37
173 INT122430 Negative_regulation of Binding of Ighm and Prkci 1 0.00 0 1.36
174 INT290542 Crh Positive_regulation of Insr 1 0.02 0.36 1.36
175 INT161511 Negative_regulation of Mapk14 Negative_regulation of Gene_expression of Il1b 1 0.41 0.27 1.36
176 INT161513 Negative_regulation of Mapk14 Negative_regulation of Gene_expression of Tnf 1 0.33 0.27 1.35
177 INT106062 Positive_regulation of Oprl1 Positive_regulation of Mapk1 1 0.13 0.16 1.35
178 INT33988 TRH Regulation of Localization of IGKV1D-39 1 0.12 0.47 1.35
179 INT106071 Positive_regulation of Oprl1 Positive_regulation of MAPK3 1 0.12 0.16 1.34
180 INT314213 Mapk14 Positive_regulation of Agtrap 1 0.04 1.15 1.34
181 INT19633 GNRH1 Regulation of Localization of CGA 4 0.44 0.82 1.33
182 INT143999 IK Regulation of Gene_expression of Penk 1 0.04 0 1.33
183 INT56087 TNF Regulation of Gene_expression of SERPINE1 1 0.43 1.67 1.33
184 INT300864 Ngf Positive_regulation of Mapk14 2 0.60 1.38 1.32
185 INT281479 Drd2 Positive_regulation of Penk 1 0.23 0.4 1.3
186 INT27425 Mtr Positive_regulation of Gene_expression of Il1f5 1 0.06 0 1.3
187 INT201942 DPP4 Negative_regulation of CXCL10 1 0.33 0.9 1.3
188 INT124926 Negative_regulation of Prkaca Negative_regulation of Localization of Pag1 1 0.00 0.61 1.3
189 INT94367 Binding of ARRB1 and TP53INP2 1 0.25 0 1.3
190 INT158144 Binding of Gpx1 and Glyat 2 0.31 0 1.29
191 INT262377 Binding of Comt and Fmod 1 0.06 1.47 1.29
192 INT135830 Gch1 Regulation of Nos2 1 0.65 0 1.29
193 INT63407 Binding of Oprl1 and Pck1 1 0.40 0 1.29
194 INT115985 Cpe Positive_regulation of Binding of Gnas 1 0.00 0.17 1.28
195 INT161995 Binding of Ctu2 and Fbxo23 1 0.06 0.33 1.28
196 INT83707 Acyp2-ps1 Regulation of Casp3 1 0.17 0 1.28
197 INT48117 GH1 Positive_regulation of CGA 1 0.10 0 1.28
198 INT83705 Acyp2-ps1 Regulation of Positive_regulation of Casp3 1 0.17 0 1.28
199 INT153923 Msr1 Positive_regulation of Gene_expression of Tdo2 1 0.00 0.89 1.28
200 INT195929 Binding of OPRM1 and Prkaca 1 0.02 0.33 1.27

Single Events

The table below shows the top 100 pain related interactions that have been reported for soluble fraction. They are ordered first by their pain relevance and then by number of times they were reported in soluble fraction. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT95787 Positive_regulation of Mapk1 568 0.70 226.51 220.94
2 INT22548 Positive_regulation of Casp3 483 0.70 258.78 213.07
3 INT94952 Positive_regulation of Mapk14 305 0.70 197.83 186.61
4 INT1114 Localization of Ins1 748 0.80 192.95 165.48
5 INT65600 Positive_regulation of Casp3 376 0.70 198.44 128.03
6 INT14151 Gene_expression of Casp3 311 0.78 140.26 120.68
7 INT7395 Localization of GNRH1 399 0.81 62.88 117.68
8 INT1793 Localization of CGA 379 0.81 67.38 114.69
9 INT49171 Gene_expression of Nos1 241 0.78 140.7 104.76
10 INT97701 Phosphorylation of Mapk14 191 0.82 115.33 100.46
11 INT52651 Positive_regulation of Prkaca 136 0.67 40.82 99.16
12 INT74058 Gene_expression of Nos1 260 0.78 80.04 95.71
13 INT1281 Negative_regulation of Maoa 203 0.59 22.47 91.66
14 INT94953 Negative_regulation of Mapk14 156 0.59 104.77 91.51
15 INT214 Localization of AVP 370 0.81 208.51 91.09
16 INT71789 Positive_regulation of MAPK1 396 0.70 234.44 89.27
17 INT96917 Positive_regulation of Mapk14 261 0.70 173.29 88.79
18 INT15898 Positive_regulation of Prkaca 199 0.70 50.89 87.54
19 INT1472 Positive_regulation of Ins1 349 0.69 146.2 86.36
20 INT5610 Positive_regulation of Insr 140 0.69 37.26 86.24
21 INT92434 Phosphorylation of Mapk1 287 0.82 91.65 83.46
22 INT99070 Gene_expression of Mapk14 147 0.78 103.99 79.59
23 INT3214 Localization of Ins1 527 0.80 196.9 79.26
24 INT2431 Positive_regulation of Mpo 275 0.70 211.99 78.47
25 INT3657 Gene_expression of Ins1 514 0.78 321.69 75.76
26 INT49111 Negative_regulation of Prkaca 102 0.59 27.44 71.77
27 INT8962 Gene_expression of Cpe 110 0.71 39.67 71.67
28 INT53964 Negative_regulation of Prkaca 131 0.58 38.76 69.52
29 INT1988 Positive_regulation of Localization of Ins1 254 0.69 59.25 68.37
30 INT46 Localization of Ren 233 0.81 46.15 62.44
31 INT48934 Positive_regulation of Mapk1 157 0.70 60.61 61.72
32 INT103924 Positive_regulation of Akt1 359 0.69 158.94 60.34
33 INT79093 Positive_regulation of Nos1 101 0.70 46.89 59.61
34 INT1794 Regulation of Localization of CGA 136 0.57 13.39 59.07
35 INT49170 Negative_regulation of Nos1 116 0.59 60.66 58.87
36 INT3920 Localization of Ldha 241 0.81 83.08 58.72
37 INT31116 Gene_expression of Casp3 192 0.78 78.21 57.43
38 INT1200 Negative_regulation of Ins1 274 0.58 155.17 56.14
39 INT314 Positive_regulation of Ren 212 0.70 66.68 55.56
40 INT78899 Gene_expression of CCL5 155 0.77 84.02 55.09
41 INT12717 Binding of Pck1 85 0.47 12.49 54.81
42 INT5034 Negative_regulation of Insr 100 0.55 28.08 54.5
43 INT117713 Phosphorylation of Akt1 275 0.82 95.82 54.34
44 INT1486 Negative_regulation of Cpe 85 0.59 28.78 54.08
45 INT2276 Regulation of Ins1 234 0.61 103.78 54.05
46 INT3213 Gene_expression of Ins1 511 0.76 357.59 53.32
47 INT96914 Phosphorylation of Mapk14 168 0.82 108.46 53.32
48 INT1487 Regulation of Cpe 68 0.62 10.24 52.91
49 INT22546 Positive_regulation of Gene_expression of Casp3 97 0.70 47.89 51.92
50 INT52264 Gene_expression of IK 180 0.77 90.87 51.87
51 INT64110 Positive_regulation of Gene_expression of Nos1 68 0.70 58.11 51.64
52 INT83199 Gene_expression of Nos3 193 0.78 100.72 51.57
53 INT5957 Positive_regulation of Cpe 65 0.69 21.07 51.22
54 INT49028 Positive_regulation of Nos1 102 0.70 34.73 51.05
55 INT2604 Positive_regulation of Got1 223 0.70 154.78 49.51
56 INT40777 Positive_regulation of Akt1 163 0.69 59.41 49.43
57 INT17915 Gene_expression of Insr 141 0.75 47.45 48.59
58 INT106525 Phosphorylation of Akt1 436 0.82 183.81 47.82
59 INT374 Positive_regulation of Ldha 212 0.70 107.08 47.43
60 INT683 Positive_regulation of AVP 173 0.70 74.55 46.41
61 INT71786 Phosphorylation of MAPK1 256 0.82 110.09 46.17
62 INT110023 Negative_regulation of Mapk14 127 0.59 84.27 45.42
63 INT2275 Negative_regulation of Localization of Ins1 183 0.59 51.02 44.94
64 INT49552 Negative_regulation of Positive_regulation of Casp3 76 0.55 36.04 44.78
65 INT27493 Negative_regulation of Casp3 114 0.56 56.89 44.63
66 INT5214 Localization of Cpe 49 0.73 13.3 44.36
67 INT4216 Gene_expression of CD40LG 328 0.78 256.02 44.23
68 INT66383 Phosphorylation of Prkaca 143 0.80 30.85 43.38
69 INT1474 Regulation of Localization of Ins1 132 0.61 25.96 43.07
70 INT5130 Regulation of GNRH1 139 0.62 31.95 42.08
71 INT65245 Gene_expression of Nos3 121 0.78 98.14 41.56
72 INT5454 Localization of CRH 124 0.79 79.18 41.53
73 INT122953 Gene_expression of COMT 65 0.77 25.84 40.49
74 INT92437 Positive_regulation of Phosphorylation of Mapk1 113 0.70 32.19 40.29
75 INT114751 Gene_expression of Mapk1 137 0.76 60.14 39.98
76 INT685 Regulation of AVP 124 0.62 34.9 39.91
77 INT2429 Negative_regulation of Mpo 128 0.59 93.76 39.57
78 INT102611 Negative_regulation of Positive_regulation of Mapk1 74 0.58 35.57 39.37
79 INT115 Negative_regulation of Maoa 65 0.59 16.27 38.66
80 INT16455 Gene_expression of Drd2 116 0.78 22.71 38.47
81 INT43507 Gene_expression of Gabbr1 79 0.78 28.53 38.22
82 INT48933 Gene_expression of Mapk3 93 0.75 44.39 37.92
83 INT97702 Positive_regulation of Phosphorylation of Mapk14 69 0.69 49.21 36.81
84 INT64558 Negative_regulation of Nos1 88 0.58 26.76 36.78
85 INT2416 Negative_regulation of MAOA 92 0.59 42.24 36.5
86 INT3216 Positive_regulation of Localization of Ins1 170 0.69 56.78 35.63
87 INT49 Negative_regulation of Ren 129 0.59 37.48 35.62
88 INT13501 Binding of Drd2 65 0.48 23.76 35.6
89 INT3679 Gene_expression of AVP 171 0.78 72.9 35.23
90 INT8747 Positive_regulation of Ins1 221 0.69 154.28 35.15
91 INT20380 Gene_expression of Il5 172 0.78 104.75 34.78
92 INT109434 Phosphorylation of Mapk1 110 0.82 61.64 34.05
93 INT48924 Positive_regulation of Mapk3 107 0.67 50.53 34.05
94 INT2699 Binding of Cpe 40 0.48 7.07 33.64
95 INT1116 Regulation of Ren 103 0.62 27.66 33.26
96 INT48925 Gene_expression of Mapk1 95 0.74 42.21 32.91
97 INT5868 Positive_regulation of GNRH1 122 0.69 20.96 32.8
98 INT89055 Phosphorylation of Prkaca 60 0.61 13.41 32.49
99 INT6683 Gene_expression of Drd2 64 0.78 11.31 32.28
100 INT73498 Gene_expression of IL13 117 0.44 83.85 32.26
101 INT114881 Gene_expression of Akt1 227 0.78 102.49 31.81
102 INT7082 Gene_expression of CRH 180 0.78 64.66 31.74
103 INT11087 Positive_regulation of Drd2 54 0.69 12.4 31.43
104 INT7396 Regulation of Localization of GNRH1 81 0.62 6.57 31.31
105 INT117112 Negative_regulation of Mapk1 87 0.56 40.34 31.18
106 INT5418 Negative_regulation of Alox5 108 0.57 42.09 31.17
107 INT23222 Binding of Phax 52 0.31 7.61 30.4
108 INT8691 Localization of Insr 85 0.80 9.27 30.32
109 INT72375 Phosphorylation of Mapk3 87 0.80 43.66 30.27
110 INT50 Negative_regulation of Localization of Ren 87 0.59 14.94 30.22
111 INT110020 Gene_expression of Mapk14 142 0.77 72.33 30.08
112 INT9053 Negative_regulation of ALOX5 97 0.58 40.34 29.94
113 INT7397 Negative_regulation of Localization of GNRH1 86 0.59 15.45 29.78
114 INT65597 Negative_regulation of Casp3 69 0.59 39.19 29.32
115 INT5300 Regulation of Insr 54 0.60 11.33 29.26
116 INT67 Negative_regulation of Ddc 66 0.59 15.34 28.96
117 INT65598 Negative_regulation of Positive_regulation of Casp3 45 0.59 18.36 28.59
118 INT8097 Gene_expression of EGF 122 0.77 75.94 28.47
119 INT7035 Regulation of CGA 87 0.45 29.04 28.45
120 INT11361 Gene_expression of SERPINE1 183 0.78 136.45 27.97
121 INT66381 Regulation of Prkaca 40 0.62 13.38 27.96
122 INT83708 Negative_regulation of MAPK1 156 0.57 84.93 27.85
123 INT112707 Negative_regulation of Akt1 89 0.59 28.85 27.76
124 INT5135 Negative_regulation of GNRH1 106 0.58 36.63 27.71
125 INT9296 Negative_regulation of PLEK 100 0.57 36.65 27.52
126 INT5604 Positive_regulation of Drd2 47 0.67 10.75 27.41
127 INT3217 Regulation of Ins1 154 0.62 87.11 27.29
128 INT69157 Gene_expression of IL5 127 0.77 102.58 26.81
129 INT90313 Negative_regulation of Gene_expression of Casp3 57 0.57 22.23 26.77
130 INT5232 Negative_regulation of Enpep 56 0.57 3.25 26.7
131 INT49850 Negative_regulation of PDE4A 105 0.58 76.91 26.59
132 INT5650 Gene_expression of Mpo 117 0.77 80.27 26.42
133 INT101120 Gene_expression of Comt 63 0.77 34.75 26.13
134 INT20044 Negative_regulation of Gpi1 50 0.59 29.96 26
135 INT22066 Gene_expression of Phax 40 0.78 22.51 25.91
136 INT95788 Positive_regulation of Positive_regulation of Mapk1 83 0.69 24.75 25.84
137 INT12124 Gene_expression of MAPK1 141 0.75 82.4 25.58
138 INT122570 Negative_regulation of Akt1 173 0.59 91.44 25.53
139 INT74688 Regulation of Nos1 55 0.62 22.16 25.3
140 INT7394 Positive_regulation of Localization of GNRH1 67 0.69 7.22 25.29
141 INT130186 Gene_expression of Ccl5 101 0.74 79.96 25.01
142 INT17625 Localization of GCG 210 0.80 55.69 24.97
143 INT2614 Gene_expression of CGA 187 0.78 105.89 24.77
144 INT12484 Binding of Drd2 45 0.48 15.17 24.72
145 INT106272 Positive_regulation of Positive_regulation of Mapk14 39 0.70 32.08 24.71
146 INT96904 Regulation of Prkaca 33 0.44 10.86 24.51
147 INT100423 Gene_expression of Bax 141 0.75 98.43 24.48
148 INT40776 Gene_expression of Akt1 99 0.77 34.91 24.39
149 INT6441 Positive_regulation of CRH 98 0.69 57.22 24.12
150 INT117718 Positive_regulation of Phosphorylation of Akt1 112 0.69 39.26 24.09
151 INT58301 Positive_regulation of Mpo 87 0.70 80.19 23.99
152 INT9155 Gene_expression of Glul 60 0.77 17.97 23.95
153 INT5131 Gene_expression of GNRH1 109 0.78 28.79 23.94
154 INT682 Negative_regulation of AVP 97 0.59 50.67 23.91
155 INT71781 Phosphorylation of MAPK3 62 0.80 27.73 23.73
156 INT22549 Positive_regulation of Positive_regulation of Casp3 48 0.56 29.5 23.7
157 INT49172 Regulation of Nos1 43 0.52 27.53 23.66
158 INT7113 Negative_regulation of Localization of CGA 71 0.51 17.7 23.42
159 INT114362 Localization of Hmgb1 127 0.78 120.28 23.26
160 INT99069 Positive_regulation of Gene_expression of Mapk14 42 0.53 29.84 23.16
161 INT18323 Negative_regulation of Localization of Ins1 122 0.58 45.74 23.04
162 INT29704 Regulation of Casp3 51 0.56 22.13 22.79
163 INT3330 Gene_expression of AGT 149 0.76 98.65 22.73
164 INT18322 Negative_regulation of Ins1 132 0.58 88.49 22.59
165 INT4369 Gene_expression of Ldha 157 0.76 88.12 22.45
166 INT4612 Positive_regulation of Localization of CGA 64 0.64 8.51 22.39
167 INT7715 Regulation of Drd2 35 0.62 10.79 22.3
168 INT2911 Positive_regulation of Glul 36 0.70 11.09 22.07
169 INT3299 Positive_regulation of AGT 126 0.68 79.45 21.91
170 INT116856 Gene_expression of TNFSF10 110 0.75 115.76 21.48
171 INT74059 Positive_regulation of Gene_expression of Nos1 55 0.70 11.5 21.39
172 INT11157 Binding of EGF 88 0.48 53.73 21.25
173 INT110638 Negative_regulation of COMT 43 0.59 21.03 21.05
174 INT112029 Positive_regulation of Pik3r1 90 0.67 38.76 20.95
175 INT6230 Localization of Ddc 40 0.79 13.11 20.88
176 INT6127 Regulation of Localization of AVP 60 0.62 15.12 20.84
177 INT1792 Positive_regulation of CGA 123 0.70 64.73 20.79
178 INT28216 Gene_expression of HRAS 173 0.75 93.97 20.78
179 INT89805 Gene_expression of Prkaca 45 0.77 11.03 20.77
180 INT49774 Binding of DRD2 48 0.48 17.42 20.73
181 INT78901 Localization of CCL5 67 0.78 40.79 20.59
182 INT519 Negative_regulation of Comt 52 0.59 17.65 20.39
183 INT125411 Negative_regulation of Phosphorylation of Mapk14 31 0.57 18.55 19.98
184 INT157463 Gene_expression of CX3CL1 55 0.62 69.05 19.75
185 INT78694 Positive_regulation of Gene_expression of Casp3 46 0.66 18.64 19.62
186 INT292049 Gene_expression of Csnk1a1 1 0.59 28.22 19.53
187 INT6993 Negative_regulation of Mpo 72 0.59 61.83 19.51
188 INT135629 Binding of COMT 33 0.48 16.68 19.37
189 INT1278 Negative_regulation of Ldha 93 0.59 37.66 19.36
190 INT70614 Gene_expression of FAS 118 0.75 112.33 19.01
191 INT5372 Localization of LHB 55 0.68 9.47 19
192 INT6351 Positive_regulation of Gabbr1 40 0.64 11.99 19
193 INT91462 Positive_regulation of Phosphorylation of MAPK1 99 0.67 40.28 18.99
194 INT89594 Gene_expression of Ccl5 44 0.54 24.08 18.62
195 INT18010 Positive_regulation of CD40LG 122 0.70 100.8 18.46
196 INT4420 Positive_regulation of GOT1 103 0.64 88.4 18.38
197 INT17442 Gene_expression of ALOX5 110 0.75 51.55 18.29
198 INT61519 Gene_expression of Mpo 112 0.78 89.29 18.22
199 INT48 Positive_regulation of Localization of Ren 69 0.70 12.47 18.03
200 INT71787 Positive_regulation of MAPK3 37 0.67 17.5 17.88
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