GO:0005626

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Name insoluble fraction
Categary Component
Go Slim No
Go Link GO:0005626
Unique Molecular Interactions 1162
Total Molecular Interactions 1414
Total Single Events 12265
Pain Genes Associated 79

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for insoluble fraction. They are ordered first by their pain relevance and then by number of times they were reported for insoluble fraction. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT206768 TP53 Positive_regulation of Ltp 2 0.01 5.83 10.21
2 INT130625 Prkcg Regulation of Prkaca 1 0.23 1.32 3.87
3 INT298456 Prkaca Positive_regulation of Phosphorylation of Adarb1 1 0.00 1.86 2.85
4 INT223866 Ltp Positive_regulation of Positive_regulation of Mapk1 2 0.46 0.75 2.61
5 INT121746 Prkaca Positive_regulation of Ephb1 2 0.23 0.92 2.35
6 INT238914 Positive_regulation of CNR1 Positive_regulation of Phosphorylation of MAPK1 1 0.19 3.22 2.35
7 INT281084 Prkaca Positive_regulation of Mapk1 2 0.25 0 2.06
8 INT104855 Prkaca Regulation of TRPV1 3 0.06 1.52 1.92
9 INT112514 Binding of Prkaca and Trib3 1 0.03 1.18 1.9
10 INT186432 Prkaca Regulation of Creb1 1 0.14 0.45 1.9
11 INT112517 Binding of Ephb1 and Prkaca 3 0.18 0.58 1.85
12 INT162992 Binding of Ephb1 and Ppm1e 1 0.03 0.25 1.77
13 INT332773 Positive_regulation of Prkaca Positive_regulation of Phosphorylation of Grin1 1 0.04 0.73 1.75
14 INT80199 Ngf Regulation of Transcription of Rab38 1 0.01 1.48 1.68
15 INT139433 Binding of Prkaca and Prkca 1 0.37 0.13 1.67
16 INT122286 Prkaca Negative_regulation of Negative_regulation of Calca 1 0.12 0.54 1.63
17 INT195930 OPRM1 Regulation of Prkaca 1 0.01 0 1.59
18 INT12327 Igh-Dex Positive_regulation of Plec 1 0.03 0.73 1.57
19 INT144280 ACP1 Negative_regulation of Phosphorylation of MAPK1 1 0.37 0.78 1.56
20 INT351366 LPA Positive_regulation of Rab38 1 0.00 0.95 1.53
21 INT121741 Prkaca Negative_regulation of Positive_regulation of Creb1 1 0.10 0.2 1.49
22 INT169800 Negative_regulation of Adrbk1 Positive_regulation of Positive_regulation of Mapk1 1 0.39 1.04 1.45
23 INT261831 Mapk1 Negative_regulation of Hspg2 1 0.00 1.26 1.42
24 INT148450 Gene_expression of Inhbe Positive_regulation of Mapk1 1 0.07 1.35 1.41
25 INT161670 H2-M3 Positive_regulation of Positive_regulation of Mapk1 1 0.14 0.73 1.41
26 INT78974 Binding of Prkcg and Prkaca 2 0.31 0.35 1.4
27 INT262568 Prkaca Regulation of Trpv1 2 0.10 0.65 1.38
28 INT106062 Positive_regulation of Oprl1 Positive_regulation of Mapk1 1 0.13 0.16 1.35
29 INT106071 Positive_regulation of Oprl1 Positive_regulation of MAPK3 1 0.12 0.16 1.34
30 INT124926 Negative_regulation of Prkaca Negative_regulation of Localization of Pag1 1 0.00 0.61 1.3
31 INT195929 Binding of OPRM1 and Prkaca 1 0.02 0.33 1.27
32 INT141244 Fos Regulation of Prkaca 1 0.18 0.07 1.24
33 INT195926 Prkaca Positive_regulation of Trpv1 1 0.10 0.44 1.24
34 INT75229 Prkaca Positive_regulation of Phosphorylation of Oprm1 1 0.44 0 1.22
35 INT76163 Prkaca Positive_regulation of Phosphorylation of Oprm1 1 0.02 0.08 1.22
36 INT166388 Binding of Gnb2l1 and Mapk1 1 0.49 0.49 1.21
37 INT139736 Htr1a Positive_regulation of Mapk3 1 0.54 0.13 1.19
38 INT121191 KCNMA1 Positive_regulation of Phosphorylation of MAPK1 1 0.06 0.61 1.18
39 INT141245 Prkaca Regulation of Gene_expression of Th 1 0.15 0.17 1.17
40 INT85780 Prkaca Regulation of Prkcg 1 0.29 0.47 1.17
41 INT169557 Cacna1h Positive_regulation of Mapk1 1 0.07 0.91 1.17
42 INT238916 CNR1 Positive_regulation of Phosphorylation of MAPK1 1 0.19 1.61 1.17
43 INT189017 Binding of Pax3 and Lmna 1 0.14 0.42 1.16
44 INT161510 Tlr4 Positive_regulation of Mapk1 1 0.14 0.3 1.16
45 INT130627 Gnas Regulation of Prkaca 1 0.00 0 1.13
46 INT269200 Prkaca Positive_regulation of Phosphorylation of Ceacam3 1 0.03 0.65 1.09
47 INT164378 MAPK3 Positive_regulation of Transcription of PDYN 1 0.50 0.2 1.09
48 INT164382 MAPK3 Positive_regulation of Gene_expression of Fos 1 0.75 0.2 1.08
49 INT352468 Calca Positive_regulation of Prkaca 1 0.11 0.8 1.08
50 INT164383 Positive_regulation of MAPK3 Positive_regulation of Gene_expression of Fos 1 0.54 0.2 1.08
51 INT96906 Plxna3 Regulation of Regulation of Prkaca 1 0.17 0.71 1.08
52 INT81582 Plec Positive_regulation of st 1 0.02 0 1.07
53 INT81581 Plec Positive_regulation of Nudt14 1 0.01 0 1.07
54 INT269198 Prkaca Regulation of Phosphorylation of Grin2a 1 0.02 0.63 1.06
55 INT269199 Prkaca Positive_regulation of Phosphorylation of Grin1 1 0.03 0.56 1.05
56 INT101067 MAP3K15 Positive_regulation of MAPK1 1 0.21 0.47 1.03
57 INT229914 Egr1 Positive_regulation of Phosphorylation of Mapk3 1 0.46 1.03 1.02
58 INT240453 Prkcg Positive_regulation of Positive_regulation of Prkaca 1 0.23 0.63 1.01
59 INT240455 Ephb1 Positive_regulation of Positive_regulation of Prkaca 1 0.22 0.63 1.01
60 INT186161 Prkaca Positive_regulation of Phosphorylation of Grin1 1 0.11 1.05 1.01
61 INT320021 Prkaca Regulation of Positive_regulation of Kcnma1 1 0.00 0.54 1
62 INT140652 IGF1 Positive_regulation of Phosphorylation of MAPK1 1 0.26 0.63 0.98
63 INT276864 Positive_regulation of Gpr65 Positive_regulation of Prkaca 1 0.16 0.74 0.97
64 INT93234 Negative_regulation of Pde4b Negative_regulation of Gene_expression of Fos 1 0.41 0.1 0.96
65 INT73461 PTPLA Positive_regulation of Transcription of TP53 1 0.06 0.99 0.96
66 INT100018 TNF Positive_regulation of MAPK1 3 0.24 1.56 0.94
67 INT252877 Prkaca Positive_regulation of Regulation of Grip2 1 0.01 0.22 0.94
68 INT144281 ACP1 Negative_regulation of Positive_regulation of MAPK1 1 0.27 0.58 0.94
69 INT330629 TP53 Negative_regulation of Gene_expression of Fos 1 0.30 1.76 0.94
70 INT252878 Prkaca Regulation of Regulation of Grip2 1 0.01 0.22 0.94
71 INT144285 ACP1 Negative_regulation of MAPK1 1 0.37 0.58 0.93
72 INT223871 Ltp Positive_regulation of Gene_expression of Mapk1 1 0.33 0 0.93
73 INT252880 Positive_regulation of Prkaca Positive_regulation of Gene_expression of Tacr1 1 0.02 0.29 0.92
74 INT195927 Binding of Prkaca and Trpv1 1 0.07 0.28 0.92
75 INT302828 Mapkapk5 Positive_regulation of Mapk1 1 0.07 1.38 0.91
76 INT135446 Map2k1 Positive_regulation of Mapk3 1 0.54 0.25 0.91
77 INT343918 IgG Positive_regulation of Phosphorylation of MAPK1 1 0.01 3.57 0.91
78 INT252876 Positive_regulation of Prkaca Regulation of Gene_expression of Tacr1 1 0.01 0.28 0.89
79 INT196834 Prkaca Positive_regulation of Phosphorylation of Ppp1r1b 2 0.15 0 0.87
80 INT188196 LIF Regulation of MAPK1 1 0.21 2.26 0.87
81 INT97738 Mdk Positive_regulation of Mapk3 1 0.08 0.66 0.87
82 INT188214 OSM Regulation of MAPK1 1 0.20 2.27 0.87
83 INT97735 Trib3 Positive_regulation of Mapk3 1 0.05 0.66 0.87
84 INT112914 Ppp1r1b Negative_regulation of Prkaca 3 0.22 0.13 0.86
85 INT330630 Binding of TP53 and Car1 1 0.23 1.56 0.86
86 INT114324 RAF1 Positive_regulation of Phosphorylation of ADCY6 1 0.02 0.05 0.85
87 INT114323 Binding of ADCY6 and RAF1 1 0.02 0.05 0.85
88 INT190183 MAPK1 Regulation of CDCP1 1 0.00 1.19 0.85
89 INT265566 Binding of PDE4D and PTPN5 1 0.03 0.81 0.85
90 INT97057 Bcl2l1 Regulation of Gene_expression of Trp53 1 0.36 0.51 0.83
91 INT97058 Cpz Regulation of Gene_expression of Trp53 1 0.27 0.57 0.83
92 INT185937 NOS2 Regulation of Prkaca 1 0.03 1.08 0.82
93 INT78972 Prkaca Regulation of Ina 1 0.11 0.09 0.82
94 INT262572 Ngf Positive_regulation of Mapk1 2 0.04 0.52 0.81
95 INT40610 Binding of Prkaca and Oprl1 1 0.02 0.09 0.8
96 INT80200 Negative_regulation of Ngf Negative_regulation of Gene_expression of Rab38 1 0.01 0.68 0.8
97 INT186439 Prkaca Regulation of Phosphorylation of Creb1 1 0.06 0.08 0.79
98 INT161520 H2-M3 Regulation of Positive_regulation of Mapk1 1 0.09 0.47 0.79
99 INT132977 Tac1 Positive_regulation of Mapk1 1 0.06 0.17 0.79
100 INT117909 Mastl Positive_regulation of Mapk1 1 0.04 0 0.79
101 INT240454 Ephb1 Regulation of Prkaca 1 0.14 0.51 0.79
102 INT91239 Prkaca Regulation of Negative_regulation of Oprm1 1 0.43 0 0.76
103 INT163830 ERBB2 Positive_regulation of MAPK1 1 0.06 1.63 0.76
104 INT69692 Helt Regulation of Prkaca 1 0.00 0.33 0.76
105 INT155096 Stat3 Regulation of Mapk3 1 0.36 0.45 0.76
106 INT107028 KNG1 Regulation of Des 1 0.01 1.7 0.76
107 INT262578 Prkaca Positive_regulation of Localization of Calca 1 0.03 0.71 0.75
108 INT196799 Prkaca Positive_regulation of Phosphorylation of Trh 1 0.02 0 0.74
109 INT162995 Positive_regulation of Binding of Ephb1 and Ppm1e 1 0.04 0.06 0.74
110 INT128404 Mapk1 Positive_regulation of Phosphorylation of Gja1 1 0.65 0.73 0.73
111 INT244025 Prkaca Regulation of Phosphorylation of Gabrg1 1 0.08 0.18 0.72
112 INT351350 Prkaca Regulation of Lpar1 1 0.04 0.58 0.72
113 INT168911 Grm5 Regulation of Mapk3 1 0.17 0.78 0.71
114 INT148449 Gene_expression of Inhbe Positive_regulation of Prkaca 1 0.05 0.68 0.71
115 INT308167 Binding of Eln and Tnfrsf1b 1 0.01 0.94 0.71
116 INT161297 Ppp1r1b Negative_regulation of Prkaca 1 0.10 0.16 0.7
117 INT166386 Mapk1 Regulation of Gene_expression of Gnb2l1 1 0.46 0.25 0.7
118 INT320633 Positive_regulation of MAPK1 Regulation of BCL2 1 0.04 1.21 0.7
119 INT186162 Phosphorylation of Prkaca Positive_regulation of Phosphorylation of Prkcg 1 0.04 0.22 0.7
120 INT194685 MAPK1 Regulation of Gene_expression of IL10 1 0.06 1.18 0.7
121 INT320634 Positive_regulation of MAPK1 Regulation of PBX2 1 0.03 1.21 0.7
122 INT223868 Mapk1 Positive_regulation of Creb1 2 0.17 0.34 0.68
123 INT223876 Mapk1 Positive_regulation of Atf6b 1 0.10 0 0.68
124 INT101986 TP53 Positive_regulation of Gene_expression of GDF15 1 0.52 2.45 0.67
125 INT211915 Fig4 Positive_regulation of Mapk3 1 0.12 0.25 0.66
126 INT211916 Fig4 Positive_regulation of Mapk1 1 0.13 0.25 0.66
127 INT191332 AMPH Positive_regulation of Mapk1 1 0.76 0 0.66
128 INT124477 MAP2K1 Positive_regulation of Positive_regulation of MAPK1 1 0.12 1.35 0.65
129 INT75764 Positive_regulation of DYT10 Positive_regulation of Phosphorylation of Plcb3 1 0.04 0.11 0.65
130 INT150754 GTS Negative_regulation of Gene_expression of Prkaca 1 0.32 0.08 0.65
131 INT148173 Positive_regulation of Grm5 Positive_regulation of Phosphorylation of Mapk1 1 0.01 0.45 0.65
132 INT235881 Prkaca Positive_regulation of Creb1 2 0.10 0.16 0.64
133 INT104858 Prkaca Negative_regulation of Negative_regulation of TRPV1 2 0.10 0.41 0.64
134 INT112513 Binding of Prkaca and Prkce 1 0.04 0.4 0.64
135 INT102863 Prkaca Regulation of Srgn 1 0.50 0.05 0.64
136 INT281081 Prkaca Positive_regulation of Gene_expression of Adcy1 1 0.12 0 0.63
137 INT253137 Ptpn1 Negative_regulation of Ins1 1 0.19 4.11 0.63
138 INT169296 PTPLA Positive_regulation of MAPK3 1 0.10 0.15 0.63
139 INT281092 Adcy1 Positive_regulation of Mapk1 1 0.21 0 0.63
140 INT281078 Prkacb Positive_regulation of Gene_expression of Adcy1 1 0.03 0 0.63
141 INT281090 Prkacb Positive_regulation of Mapk1 1 0.06 0 0.62
142 INT281091 Prkacb Positive_regulation of Mdk 1 0.02 0 0.62
143 INT324065 Ptger2 Positive_regulation of Prkaca 2 0.24 0.63 0.61
144 INT166402 CDKN1A Regulation of Gene_expression of TP53 1 0.27 0.83 0.61
145 INT281086 Prkaca Positive_regulation of Mdk 1 0.08 0 0.61
146 INT166385 Binding of Araf and Gnb2l1 1 0.23 0.24 0.6
147 INT223158 Mapk3 Regulation of Gene_expression of Mapk14 1 0.48 1.33 0.59
148 INT120348 Negative_regulation of Binding of DES and MYC 1 0.06 0.18 0.58
149 INT291262 Positive_regulation of INS Positive_regulation of Mapk1 1 0.03 1.78 0.58
150 INT244055 Prkaca Regulation of Gabrg1 1 0.08 0 0.58
151 INT102864 Prkaca Regulation of Twist1 1 0.48 0.05 0.58
152 INT120349 Binding of BDKRB1 and DES 1 0.05 0.17 0.58
153 INT120350 Binding of DES and MYC 1 0.05 0.17 0.58
154 INT291258 INS Positive_regulation of Mapk1 1 0.04 1.77 0.58
155 INT115146 MAPK1 Positive_regulation of EGR1 3 0.13 2.43 0.57
156 INT148172 Mapk1 Positive_regulation of Phosphorylation of Kcnd2 1 0.49 0.55 0.57
157 INT356320 ORF61 Positive_regulation of Positive_regulation of Prkaca 1 0.01 0.05 0.57
158 INT296472 Camk2a Positive_regulation of Prkaca 1 0.09 0.32 0.57
159 INT120870 Binding of Wnk1 and Sptlc1 1 0.14 1.24 0.56
160 INT261485 Positive_regulation of Prkaca Positive_regulation of Phosphorylation of Ephb1 1 0.05 0.12 0.56
161 INT323148 PRKCA Positive_regulation of RAF1 1 0.01 0 0.55
162 INT201949 CXCL10 Positive_regulation of Phosphorylation of MAPK1 1 0.15 0.79 0.55
163 INT103184 Prkaca Positive_regulation of Phosphorylation of CRTC1 1 0.01 0.57 0.55
164 INT121994 EGF Positive_regulation of Positive_regulation of MAPK1 1 0.25 0 0.55
165 INT99486 OPRM1 Positive_regulation of MAPK3 1 0.22 0 0.55
166 INT296293 Prkaca Regulation of Positive_regulation of Creb1 1 0.16 0.62 0.55
167 INT296291 Prkaca Regulation of Localization of Calm3 1 0.09 0.62 0.55
168 INT296273 Prkaca Regulation of Localization of Camk4 1 0.16 0.62 0.55
169 INT323150 PRKCA Positive_regulation of Phosphorylation of RAF1 1 0.01 0 0.55
170 INT350169 Binding of DMD and MRI1 1 0.11 3.08 0.54
171 INT89059 Positive_regulation of Prkaca Positive_regulation of Gene_expression of Trpv1 1 0.07 0.16 0.54
172 INT323146 PRKCA Positive_regulation of MAPK1 1 0.02 0 0.54
173 INT85125 IL3 Positive_regulation of MAPK1 1 0.30 0.81 0.53
174 INT85121 CSF2 Positive_regulation of MAPK1 1 0.07 0.8 0.53
175 INT85115 IL5 Positive_regulation of MAPK1 1 0.14 0.81 0.53
176 INT106394 MAPK3 Positive_regulation of ADRBK1 1 0.48 0.06 0.53
177 INT162991 Binding of Fadd and Ppm1e 1 0.03 0.09 0.52
178 INT254200 Mif Regulation of Trp53 1 0.02 0.96 0.52
179 INT171909 MAPK8 Positive_regulation of Gene_expression of MAPK1 1 0.08 1.55 0.52
180 INT87559 Vip Positive_regulation of Prkaca 1 0.28 0 0.52
181 INT171910 MAPK1 Positive_regulation of MAPK9 1 0.10 1.55 0.52
182 INT87557 Crh Positive_regulation of Prkaca 1 0.27 0 0.52
183 INT201939 CXCL10 Positive_regulation of MAPK1 1 0.11 0.72 0.52
184 INT171906 MAPK1 Positive_regulation of Gene_expression of MAPK14 1 0.08 1.55 0.52
185 INT196830 Arpp21 Regulation of Prkaca 1 0.01 0 0.52
186 INT171914 MAPK8IP3 Positive_regulation of Gene_expression of MAPK1 1 0.06 1.55 0.52
187 INT303720 Prkaca Regulation of Bdkrb1 1 0.02 0.33 0.52
188 INT122872 SEMA6A Positive_regulation of MAPK1 1 0.56 0 0.52
189 INT89058 Prkaca Regulation of Phosphorylation of Trpv1 1 0.04 0.35 0.51
190 INT131368 MAPK1 Positive_regulation of Bcar3 1 0.00 0.37 0.51
191 INT196824 Ppp1r1b Regulation of Prkaca 1 0.10 0 0.51
192 INT342689 Ptger4 Positive_regulation of Prkaca 1 0.03 0.24 0.51
193 INT131371 MAPK3 Positive_regulation of Il4 1 0.02 0.37 0.51
194 INT131367 MAPK3 Positive_regulation of Bcar3 1 0.00 0.37 0.51
195 INT131370 MAPK3 Positive_regulation of Gene_expression of Il4 1 0.02 0.37 0.51
196 INT87558 Calca Positive_regulation of Prkaca 1 0.35 0 0.51
197 INT131369 MAPK1 Positive_regulation of Il4 1 0.01 0.37 0.51
198 INT262565 Prkaca Regulation of Negative_regulation of Trpv1 1 0.05 0.21 0.5
199 INT356286 Ngf Regulation of Positive_regulation of Mapk1 1 0.03 0.76 0.5
200 INT356279 Gdnf Regulation of Positive_regulation of Mapk1 1 0.03 0.76 0.5

Single Events

The table below shows the top 100 pain related interactions that have been reported for insoluble fraction. They are ordered first by their pain relevance and then by number of times they were reported in insoluble fraction. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT95787 Positive_regulation of Mapk1 568 0.70 226.51 220.94
2 INT52651 Positive_regulation of Prkaca 136 0.67 40.82 99.16
3 INT71789 Positive_regulation of MAPK1 396 0.70 234.44 89.27
4 INT15898 Positive_regulation of Prkaca 199 0.70 50.89 87.54
5 INT92434 Phosphorylation of Mapk1 287 0.82 91.65 83.46
6 INT49111 Negative_regulation of Prkaca 102 0.59 27.44 71.77
7 INT53964 Negative_regulation of Prkaca 131 0.58 38.76 69.52
8 INT48934 Positive_regulation of Mapk1 157 0.70 60.61 61.72
9 INT71786 Phosphorylation of MAPK1 256 0.82 110.09 46.17
10 INT66383 Phosphorylation of Prkaca 143 0.80 30.85 43.38
11 INT92437 Positive_regulation of Phosphorylation of Mapk1 113 0.70 32.19 40.29
12 INT114751 Gene_expression of Mapk1 137 0.76 60.14 39.98
13 INT102611 Negative_regulation of Positive_regulation of Mapk1 74 0.58 35.57 39.37
14 INT48933 Gene_expression of Mapk3 93 0.75 44.39 37.92
15 INT109434 Phosphorylation of Mapk1 110 0.82 61.64 34.05
16 INT48924 Positive_regulation of Mapk3 107 0.67 50.53 34.05
17 INT48925 Gene_expression of Mapk1 95 0.74 42.21 32.91
18 INT89055 Phosphorylation of Prkaca 60 0.61 13.41 32.49
19 INT117112 Negative_regulation of Mapk1 87 0.56 40.34 31.18
20 INT72375 Phosphorylation of Mapk3 87 0.80 43.66 30.27
21 INT28361 Gene_expression of TP53 443 0.78 384.86 28.8
22 INT66381 Regulation of Prkaca 40 0.62 13.38 27.96
23 INT83708 Negative_regulation of MAPK1 156 0.57 84.93 27.85
24 INT49850 Negative_regulation of PDE4A 105 0.58 76.91 26.59
25 INT95788 Positive_regulation of Positive_regulation of Mapk1 83 0.69 24.75 25.84
26 INT12124 Gene_expression of MAPK1 141 0.75 82.4 25.58
27 INT96904 Regulation of Prkaca 33 0.44 10.86 24.51
28 INT71781 Phosphorylation of MAPK3 62 0.80 27.73 23.73
29 INT89805 Gene_expression of Prkaca 45 0.77 11.03 20.77
30 INT91462 Positive_regulation of Phosphorylation of MAPK1 99 0.67 40.28 18.99
31 INT71787 Positive_regulation of MAPK3 37 0.67 17.5 17.88
32 INT65856 Positive_regulation of TP53 138 0.67 112.65 16.71
33 INT93361 Gene_expression of Trp53 208 0.78 175.35 16.65
34 INT95790 Regulation of Mapk1 55 0.61 21.17 16.31
35 INT80972 Gene_expression of Tp53 104 0.78 102.74 16.02
36 INT111462 Negative_regulation of Phosphorylation of Mapk1 45 0.57 19.49 15.59
37 INT75531 Regulation of MAPK1 70 0.61 34.39 15.42
38 INT128401 Positive_regulation of Positive_regulation of Mapk1 39 0.70 10.88 15.38
39 INT16167 Negative_regulation of DMD 186 0.57 108.71 15.25
40 INT16166 Positive_regulation of DMD 348 0.67 133.22 15.06
41 INT77619 Gene_expression of Prkaca 43 0.75 8.55 14.13
42 INT80688 Positive_regulation of Positive_regulation of MAPK1 72 0.69 39.35 14.11
43 INT49089 Gene_expression of Rab38 22 0.45 6.79 13.76
44 INT111529 Phosphorylation of Mapk3 41 0.80 21.14 13.72
45 INT12325 Gene_expression of Plec 47 0.72 11.92 13.35
46 INT48927 Regulation of Mapk3 25 0.60 14.06 12.82
47 INT150676 Positive_regulation of Gene_expression of Mapk1 30 0.45 10.06 12.37
48 INT119396 Regulation of Positive_regulation of Mapk1 22 0.61 7.88 12.25
49 INT49087 Positive_regulation of Rab38 20 0.00 8.01 12
50 INT114674 Gene_expression of Mdm2 15 0.78 3.51 11.85
51 INT78970 Positive_regulation of Positive_regulation of Prkaca 14 0.47 3.06 11.49
52 INT25963 Gene_expression of DES 122 0.75 98.81 11.25
53 INT75525 Negative_regulation of Positive_regulation of MAPK1 40 0.59 25.15 11.15
54 INT27651 Gene_expression of S100A12 45 0.76 52.25 10.51
55 INT48921 Regulation of Mapk1 25 0.49 19.51 10.41
56 INT87451 Positive_regulation of Mapk3 34 0.67 12.82 10.38
57 INT169997 Positive_regulation of Gene_expression of Tp53 37 0.70 47.3 9.85
58 INT66382 Positive_regulation of Phosphorylation of Prkaca 33 0.49 7.05 9.69
59 INT40609 Binding of Prkaca 23 0.36 3.42 9.19
60 INT94196 Negative_regulation of Phosphorylation of MAPK1 60 0.59 31.64 9.16
61 INT109432 Negative_regulation of Phosphorylation of Mapk1 19 0.54 7.01 8.98
62 INT111133 Negative_regulation of Mapk3 31 0.57 10.89 8.9
63 INT71478 Positive_regulation of Positive_regulation of Prkaca 21 0.37 5.14 8.85
64 INT9968 Negative_regulation of Rab38 15 0.00 10.45 8.64
65 INT6810 Gene_expression of ENO2 70 0.78 54.8 8.35
66 INT126848 Positive_regulation of Phosphorylation of Mapk1 30 0.50 15.94 8.34
67 INT71785 Gene_expression of MAPK3 22 0.75 11.35 8.21
68 INT6557 Gene_expression of Eno2 65 0.77 54.42 8.17
69 INT142526 Positive_regulation of Gene_expression of Prkaca 12 0.46 2.48 8.05
70 INT82762 Positive_regulation of Positive_regulation of Mapk3 23 0.67 7.72 7.91
71 INT114675 Positive_regulation of Gene_expression of Mdm2 1 0.70 1.98 7.9
72 INT72372 Positive_regulation of Phosphorylation of Mapk3 30 0.67 13.6 7.69
73 INT91618 Positive_regulation of Phosphorylation of MAPK3 21 0.67 7.99 7.65
74 INT57748 Positive_regulation of Gene_expression of TP53 85 0.69 79.55 7.49
75 INT79456 Gene_expression of PDE4A 35 0.77 19.42 7.42
76 INT89309 Negative_regulation of Pde4b 21 0.53 12.81 7.32
77 INT73181 Gene_expression of Hspb1 24 0.78 15.84 7.31
78 INT97055 Positive_regulation of Gene_expression of Trp53 51 0.70 45.7 7.25
79 INT89052 Positive_regulation of Phosphorylation of Prkaca 13 0.37 2.92 7.05
80 INT71496 Positive_regulation of Hspb1 15 0.69 14.7 6.86
81 INT68466 Negative_regulation of Positive_regulation of Prkaca 6 0.57 2.29 6.83
82 INT25467 Regulation of Rab38 19 0.00 8.68 6.73
83 INT48928 Positive_regulation of Gene_expression of Mapk1 19 0.48 9.38 6.59
84 INT93359 Positive_regulation of Trp53 90 0.70 69.77 6.24
85 INT94197 Negative_regulation of Phosphorylation of MAPK3 13 0.57 5.51 6.18
86 INT48926 Positive_regulation of Gene_expression of Mapk3 12 0.46 6.02 6.13
87 INT139964 Regulation of Phosphorylation of Mapk1 12 0.58 10.04 6.1
88 INT1493 Positive_regulation of Prkacb 8 0.59 2.75 5.99
89 INT112545 Phosphorylation of TP53 28 0.80 14.13 5.93
90 INT130111 Regulation of Positive_regulation of MAPK1 14 0.36 11.01 5.9
91 INT85777 Regulation of Negative_regulation of Prkaca 7 0.46 1.85 5.76
92 INT71477 Negative_regulation of Positive_regulation of Prkaca 10 0.37 1.69 5.57
93 INT62336 Positive_regulation of Hdc 38 0.70 14.45 5.51
94 INT13396 Gene_expression of DMD 125 0.75 57.81 5.45
95 INT71779 Positive_regulation of Gene_expression of MAPK1 27 0.47 21.41 5.39
96 INT99487 Negative_regulation of MAPK3 15 0.57 7.13 5.39
97 INT95696 Gene_expression of Dmd 130 0.68 26.02 5.34
98 INT60585 Regulation of TP53 59 0.59 54.55 5.21
99 INT127668 Positive_regulation of PDE4A 12 0.68 8.39 5.13
100 INT22707 Positive_regulation of Eno2 36 0.69 27.31 5.07
101 INT29893 Negative_regulation of Prkacb 4 0.37 1.14 5.04
102 INT15652 Positive_regulation of ENO2 37 0.68 33.39 5.02
103 INT71244 Binding of Prkaca 8 0.30 2.64 4.96
104 INT121471 Negative_regulation of Pde3a 24 0.34 13.79 4.73
105 INT109972 Phosphorylation of Trp53 13 0.80 6.15 4.68
106 INT62684 Negative_regulation of TP53 66 0.58 66.09 4.62
107 INT75761 Positive_regulation of Phosphorylation of Plcb3 1 0.05 0.22 4.58
108 INT1490 Regulation of Prkacb 7 0.21 0.5 4.52
109 INT205272 Positive_regulation of Gene_expression of Plec 11 0.43 1.5 4.49
110 INT57749 Negative_regulation of Gene_expression of TP53 39 0.56 36.79 4.45
111 INT75759 Phosphorylation of Plcb3 1 0.06 0.22 4.42
112 INT108354 Negative_regulation of Phosphorylation of Prkaca 18 0.41 6.24 4.37
113 INT111535 Negative_regulation of Phosphorylation of Mapk3 9 0.57 6.39 4.31
114 INT105171 Phosphorylation of RAF1 11 0.74 2.33 4.19
115 INT158416 Localization of Mapk1 19 0.67 5.32 4.18
116 INT133244 Regulation of Positive_regulation of Mapk1 11 0.43 3.52 4.03
117 INT112782 Localization of Mapk3 8 0.78 1.87 3.98
118 INT105779 Gene_expression of Pde4b 7 0.73 3.33 3.91
119 INT120742 Negative_regulation of Gene_expression of Prkaca 6 0.24 3.76 3.86
120 INT113924 Binding of Mapk1 27 0.38 8.64 3.84
121 INT123827 Positive_regulation of Phosphorylation of Mapk3 10 0.67 5.22 3.82
122 INT94291 Regulation of Gene_expression of Mapk3 4 0.40 3.05 3.8
123 INT54116 Negative_regulation of Eno2 6 0.41 2.78 3.71
124 INT71602 Negative_regulation of Trp53 84 0.59 67.77 3.68
125 INT16165 Regulation of DMD 114 0.60 35.13 3.64
126 INT116623 Localization of Prkaca 15 0.73 2.89 3.59
127 INT99593 Gene_expression of Grk6 3 0.78 3.19 3.52
128 INT25356 Positive_regulation of S100A12 18 0.69 17.62 3.38
129 INT171998 Binding of DMD 58 0.47 38.13 3.35
130 INT129751 Regulation of Phosphorylation of Mapk3 11 0.55 3.91 3.35
131 INT119421 Negative_regulation of RAF1 10 0.41 6.94 3.31
132 INT97737 Negative_regulation of Phosphorylation of Mapk3 9 0.57 5.64 3.3
133 INT51607 Positive_regulation of DES 33 0.67 32.24 3.29
134 INT78969 Regulation of Positive_regulation of Prkaca 5 0.37 1.38 3.29
135 INT25466 Binding of Rab38 6 0.00 2.23 3.28
136 INT76680 Positive_regulation of Il1rap 5 0.24 4.5 3.21
137 INT171368 Regulation of Phosphorylation of Mapk1 14 0.61 4.77 3.14
138 INT71783 Positive_regulation of Gene_expression of MAPK3 9 0.59 4.59 3.05
139 INT87288 Positive_regulation of Positive_regulation of MAPK3 5 0.67 1.62 3.04
140 INT222742 Regulation of S100A12 4 0.53 12.09 3.03
141 INT15584 Binding of S100A12 14 0.48 15.14 3
142 INT8103 Binding of TP53 46 0.44 40.2 2.96
143 INT11920 Regulation of ENO2 18 0.55 11.51 2.89
144 INT154334 Localization of S100A12 9 0.80 9.32 2.89
145 INT200895 Localization of Mapk1 6 0.67 2.08 2.82
146 INT169112 Negative_regulation of Positive_regulation of Mapk1 9 0.59 1.84 2.78
147 INT145821 Negative_regulation of Gene_expression of Mapk1 16 0.41 8.05 2.77
148 INT24068 Localization of Hspb1 6 0.78 6.11 2.75
149 INT152927 Negative_regulation of Mapk1 16 0.41 5.85 2.73
150 INT109969 Positive_regulation of Phosphorylation of Trp53 1 0.45 2.18 2.66
151 INT98557 Regulation of PDE4A 12 0.44 8.42 2.56
152 INT52871 Regulation of Hdc 6 0.60 3.26 2.51
153 INT109968 Positive_regulation of Positive_regulation of Trp53 6 0.47 3.57 2.51
154 INT1216 Negative_regulation of Pde4b 9 0.41 2.65 2.5
155 INT37621 Gene_expression of Des 6 0.65 2.17 2.48
156 INT258581 Gene_expression of Il1rap 3 0.14 2.59 2.43
157 INT137270 Positive_regulation of PDE4D 4 0.48 2.48 2.39
158 INT79402 Gene_expression of Pde4b 7 0.74 3 2.38
159 INT87284 Negative_regulation of Positive_regulation of MAPK3 7 0.41 2.65 2.38
160 INT55952 Transcription of TP53 16 0.61 12.14 2.36
161 INT80194 Transcription of Rab38 4 0.04 1.85 2.35
162 INT94984 Regulation of Grk6 1 0.42 0 2.34
163 INT114327 Positive_regulation of RAF1 26 0.51 20.87 2.32
164 INT186116 Regulation of Gene_expression of MAPK1 9 0.44 5.85 2.32
165 INT85284 Negative_regulation of ENO2 8 0.58 7.86 2.28
166 INT93341 Localization of Prkaca 7 0.59 2.04 2.28
167 INT59784 Binding of DES 22 0.47 19.48 2.27
168 INT30061 Negative_regulation of Hdc 8 0.59 2.14 2.27
169 INT34596 Binding of Des 5 0.36 3.26 2.27
170 INT86426 Gene_expression of Hspb1 16 0.78 10.86 2.26
171 INT135925 Regulation of Pde4b 5 0.41 1.58 2.24
172 INT76160 Phosphorylation of Prkacb 4 0.09 0.19 2.24
173 INT51869 Negative_regulation of Dmd 24 0.52 10.4 2.18
174 INT76681 Transcription of Il1rap 3 0.25 4.46 2.18
175 INT103179 Regulation of Phosphorylation of Prkaca 6 0.45 0.79 2.15
176 INT65119 Negative_regulation of Des 4 0.41 1.29 2.14
177 INT170482 Regulation of Gene_expression of Mapk1 5 0.43 5.73 2.1
178 INT156064 Gene_expression of LMNA 50 0.65 13.38 2.01
179 INT109906 Localization of MAPK1 12 0.54 1.68 2.01
180 INT83709 Negative_regulation of Gene_expression of MAPK1 12 0.41 6.57 2.01
181 INT169874 Positive_regulation of Gene_expression of Prkaca 11 0.38 1.64 2.01
182 INT56817 Regulation of Eno2 16 0.61 10.64 1.99
183 INT125080 Positive_regulation of Positive_regulation of TP53 21 0.58 16.16 1.98
184 INT121781 Regulation of Mapk3 5 0.44 1.96 1.98
185 INT163980 Gene_expression of Hdc 12 0.65 4.47 1.96
186 INT146793 Positive_regulation of Tp53 30 0.70 32.93 1.94
187 INT65855 Localization of TP53 18 0.76 17.08 1.89
188 INT80221 Regulation of Eno2 4 0.35 4.64 1.89
189 INT179670 Protein_catabolism of Eln 3 0.19 6.16 1.84
190 INT23956 Negative_regulation of DES 12 0.42 10.84 1.82
191 INT63716 Transcription of Hdc 10 0.69 7.57 1.82
192 INT118683 Regulation of Phosphorylation of MAPK3 3 0.44 2.92 1.82
193 INT135928 Positive_regulation of Binding of Pde4b 3 0.45 0.18 1.81
194 INT113345 Positive_regulation of Phosphorylation of TP53 8 0.66 6.11 1.8
195 INT79401 Regulation of Gene_expression of Pde4b 4 0.59 1.26 1.8
196 INT82760 Negative_regulation of Positive_regulation of Mapk3 7 0.57 3.18 1.78
197 INT119905 Negative_regulation of PDE3A 5 0.18 5 1.77
198 INT178389 Positive_regulation of Eno2 3 0.06 1.01 1.76
199 INT122503 Localization of CAPN2 1 0.35 1.43 1.76
200 INT205266 Regulation of Gene_expression of Plec 3 0.57 1.45 1.74
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