GO:0005637

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Name nuclear inner membrane
Categary Component
Go Slim No
Go Link GO:0005637
Unique Molecular Interactions 202
Total Molecular Interactions 275
Total Single Events 1762
Pain Genes Associated 23

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for nuclear inner membrane. They are ordered first by their pain relevance and then by number of times they were reported for nuclear inner membrane. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT37873 Pag1 Regulation of Nrm 2 0.04 1.1 2.41
2 INT89733 Binding of Calca and Nrm 1 0.31 0.71 2.09
3 INT142073 Binding of Helt and Nrm 1 0.00 0 1.74
4 INT340300 Ea1 Positive_regulation of Gene_expression of Sirt1 1 0.08 1.68 1.49
5 INT28992 Tmpo Positive_regulation of Pomc 1 0.36 3.18 1.41
6 INT110542 SIGMAR1 Regulation of OPRM1 1 0.04 0.33 1.25
7 INT110543 SIGMAR1 Regulation of Gene_expression of OPRM1 1 0.04 0.33 1.25
8 INT121000 Binding of PAG1 and Nrm 1 0.13 0.67 1.25
9 INT13603 Binding of NCF4 and Nrm 2 0.40 0.21 1.22
10 INT120205 Binding of App and Ern1 1 0.05 2.55 1.18
11 INT76256 Binding of Slc6a3 and Sigmar1 1 0.20 0 1.16
12 INT151218 Negative_regulation of SIGMAR1 Negative_regulation of Positive_regulation of Akt1 1 0.00 0.26 1.03
13 INT107335 Pdpk1 Positive_regulation of Regulation of Sigmar1 1 0.02 0 0.93
14 INT161048 Nrm Positive_regulation of Prdm4 1 0.56 1.47 0.86
15 INT340294 Ea1 Positive_regulation of Sirt1 1 0.06 0.53 0.83
16 INT128861 LBR Positive_regulation of Positive_regulation of OPRM1 1 0.19 0.36 0.75
17 INT106691 Ngf Positive_regulation of SIGMAR1 1 0.04 0 0.74
18 INT37874 Positive_regulation of Pag1 Regulation of Nrm 1 0.04 0.59 0.71
19 INT46892 Positive_regulation of Binding of Pag1 and Nrm 1 0.01 0.61 0.63
20 INT46891 Binding of Pag1 and Nrm 1 0.01 0.61 0.63
21 INT96765 LBR Positive_regulation of Gene_expression of TP53INP2 1 0.11 0.5 0.62
22 INT61507 Ghrhr Positive_regulation of Localization of Gh1 1 0.41 0 0.61
23 INT95895 Sigmar1 Regulation of Positive_regulation of Npy 1 0.18 0 0.55
24 INT176371 LBR Positive_regulation of IL12A 1 0.04 1.22 0.55
25 INT176367 LBR Positive_regulation of IFNA1 1 0.02 1.22 0.55
26 INT343913 Binding of FOS and Smad3 1 0.19 0.92 0.54
27 INT21372 Binding of pcp and Sigmar1 1 0.01 0 0.53
28 INT54599 Positive_regulation of Ascla2 Positive_regulation of Nrm 1 0.00 0.14 0.52
29 INT151220 Negative_regulation of SIGMAR1 Negative_regulation of Positive_regulation of Prkca 1 0.00 0.13 0.51
30 INT151222 Negative_regulation of SIGMAR1 Negative_regulation of Positive_regulation of Adrbk1 1 0.00 0.13 0.51
31 INT151223 Negative_regulation of SIGMAR1 Negative_regulation of Adrbk1 1 0.00 0.13 0.51
32 INT151219 Negative_regulation of SIGMAR1 Negative_regulation of Prkca 1 0.00 0.13 0.51
33 INT151221 Negative_regulation of SIGMAR1 Negative_regulation of Akt1 1 0.00 0.13 0.51
34 INT48102 Positive_regulation of LBR Positive_regulation of Positive_regulation of OR7A5 1 0.21 0 0.48
35 INT340296 Ea1 Regulation of Gene_expression of Sirt1 1 0.08 0.15 0.46
36 INT176366 LBR Regulation of IFNA1 1 0.04 0.91 0.46
37 INT99160 Binding of Mpo and Nrm 1 0.38 0.92 0.45
38 INT12453 Sigmar1 Regulation of Gene_expression of Penk 2 0.35 0 0.43
39 INT176361 Positive_regulation of LBR Positive_regulation of Gene_expression of IL18 1 0.10 0.84 0.39
40 INT28991 Tmpo Positive_regulation of Gene_expression of Pomc 1 0.34 0.82 0.37
41 INT224584 Binding of IL1RN and SIGMAR1 1 0.00 0.73 0.36
42 INT99159 Nrm Positive_regulation of Mpo 1 0.44 0.85 0.36
43 INT194865 Binding of SIGMAR1 and Positive_regulation of IL1B 1 0.01 0.62 0.35
44 INT194862 SIGMAR1 Positive_regulation of IL1B 1 0.01 0.62 0.35
45 INT28327 Binding of Sigmar1 and Abat 1 0.15 0.14 0.35
46 INT176363 IFNA1 Regulation of Positive_regulation of LBR 1 0.04 0.69 0.34
47 INT307017 LBR Positive_regulation of Gene_expression of TNF 1 0.02 0.58 0.32
48 INT307014 LBR Positive_regulation of Gene_expression of IL6 1 0.01 0.58 0.32
49 INT21321 Pomc Positive_regulation of LBR 1 0.04 0 0.31
50 INT194858 Binding of IL1B and SIGMAR1 1 0.01 0.55 0.3
51 INT158621 Binding of SIGMAR1 and Sphk1 1 0.01 0 0.25
52 INT269561 TMPO Positive_regulation of RHOA 1 0.22 0 0.23
53 INT136492 Binding of Adarb1 and Sigmar1 1 0.03 0.1 0.21
54 INT269322 TMPO Positive_regulation of Positive_regulation of NOS1 1 0.03 0 0.18
55 INT190628 Negative_regulation of Binding of Rab7 and Sirt1 1 0.33 0.62 0.17
56 INT190638 Binding of Rab7 and Sirt1 1 0.29 0.62 0.17
57 INT182326 LBR Positive_regulation of Gene_expression of Birc5 1 0.00 0.46 0.17
58 INT18043 Binding of SIGMAR1 and Pgr 1 0.00 0.06 0.16
59 INT289525 Sirt1 Negative_regulation of Negative_regulation of Ucp2 1 0.32 0.86 0.15
60 INT269325 DYNC1I2 Positive_regulation of TMPO 1 0.01 0 0.15
61 INT94763 PSEN2 Regulation of Positive_regulation of App 1 0.11 0.72 0.14
62 INT269326 PRKCA Positive_regulation of Localization of TMPO 1 0.01 0 0.13
63 INT269336 PRKCA Regulation of Localization of TMPO 1 0.01 0.12 0.13
64 INT311905 Binding of Runx2 and Smad1 1 0.12 0.46 0.13
65 INT311912 Gene_expression of Smad1 Positive_regulation of Gene_expression of Mmp13 1 0.08 0.51 0.12
66 INT269332 Binding of NOS3 and TMPO 1 0.01 0 0.12
67 INT145207 Binding of Sigmar1 and Ctdspl2 1 0.00 0 0.12
68 INT145214 Binding of Sigmar1 and Herc1 1 0.00 0 0.11
69 INT39207 LBR Positive_regulation of Gene_expression of IL2 1 0.23 0 0.11
70 INT66109 SIGMAR1 Regulation of Localization of Pomc 1 0.00 0 0.1
71 INT154711 Binding of SGCG and Rnf13 1 0.36 0.76 0.1
72 INT269415 Prkaca Regulation of Localization of TMPO 1 0.00 0 0.1
73 INT289539 Negative_regulation of Sirt1 Negative_regulation of Gene_expression of Agrp 1 0.29 0.47 0.09
74 INT246625 Sirt1 Positive_regulation of Negative_regulation of Trp53 1 0.10 0.96 0.08
75 INT269324 Regulation of TNIP3 Negative_regulation of TMPO 1 0.00 0 0.08
76 INT289536 Sirt1 Negative_regulation of Localization of Pparg 1 0.13 0.43 0.08
77 INT289603 Sirt1 Negative_regulation of Localization of PPARG 1 0.02 0.43 0.08
78 INT269327 PRKG1 Regulation of Localization of TMPO 1 0.02 0 0.08
79 INT289540 Sirt1 Negative_regulation of Localization of Ins1 1 0.03 0.43 0.08
80 INT289533 Sirt1 Negative_regulation of Pparg 1 0.18 0.42 0.07
81 INT102636 Binding of Sigmar1 and Mir377 1 0.05 0.19 0.07
82 INT256160 Positive_regulation of Binding of Pgc and Sirt1 1 0.55 0.21 0.07
83 INT289602 Sirt1 Negative_regulation of PPARG 1 0.02 0.37 0.07
84 INT256161 Binding of Pgc and Sirt1 1 0.38 0.21 0.07
85 INT269323 TNIP3 Negative_regulation of TMPO 1 0.00 0 0.07
86 INT311916 Smad3 Negative_regulation of Gene_expression of Mmp13 1 0.12 0.27 0.06
87 INT311910 Acvrl1 Positive_regulation of Phosphorylation of Smad1 1 0.12 0.24 0.06
88 INT269568 PTGIR Regulation of TMPO 1 0.01 0.06 0.05
89 INT252823 Binding of TNF and SIGMAR1 1 0.01 0.95 0.05
90 INT316015 AIC Regulation of ERN1 1 0.08 0.1 0.05
91 INT269556 PTGIR Negative_regulation of TMPO 1 0.01 0 0.05
92 INT340293 Binding of Ins1 and Sirt1 1 0.25 1.25 0.05
93 INT193970 Binding of PSEN1 and Psen2 1 0.36 2.06 0.05
94 INT307007 MT1JP Positive_regulation of Localization of LBR 1 0.01 0 0.05
95 INT353294 Binding of Smad2 and Smad3 1 0.15 0.08 0.04
96 INT289541 Sirt1 Regulation of Gene_expression of Agrp 1 0.41 0.52 0.04
97 INT353295 Binding of Smad3 and Smad4 1 0.17 0.08 0.04
98 INT289538 Sirt1 Positive_regulation of Stat3 1 0.34 0.37 0.04
99 INT323707 LBR Positive_regulation of MIR146A 1 0.02 0.1 0.03
100 INT269596 TMPO Positive_regulation of Localization of CA2 1 0.12 0.06 0.03
101 INT331477 PSEN2 Regulation of Gene_expression of Psen1 1 0.00 0.15 0.03
102 INT311904 Smad2 Positive_regulation of Gene_expression of Smad1 1 0.13 0.44 0.03
103 INT354896 Binding of Psen2 and Fancd2 1 0.04 0.75 0.03
104 INT269589 MAPKAP1 Regulation of TMPO 1 0.03 0.07 0.03
105 INT319219 Bmpr2 Positive_regulation of Smad1 1 0.18 0.29 0.03
106 INT289542 Sirt1 Negative_regulation of Stat3 1 0.32 0.31 0.03
107 INT254852 Binding of Col7a1 and Smad3 1 0.01 0.57 0.03
108 INT289526 Binding of Arc and Sirt1 1 0.08 0.55 0.03
109 INT331478 Psen1 Regulation of Gene_expression of PSEN2 1 0.00 0.15 0.03
110 INT319217 Bmpr2 Positive_regulation of Gene_expression of Smad1 1 0.19 0.11 0.03
111 INT289599 Sirt1 Positive_regulation of Ppargc1a 1 0.51 0.36 0.03
112 INT180040 Binding of D7Cwr3P and Sirt1 1 0.00 0 0
113 INT300696 Sirt1 Regulation of Cyb5r3 1 0.03 0 0
114 INT269943 Sox17 Regulation of Binding of Smad3 1 0.37 0.12 0
115 INT269567 TMPO Positive_regulation of PTGDS 1 0.07 0 0
116 INT254849 Negative_regulation of Rhoa Positive_regulation of Phosphorylation of Smad3 1 0.11 0.45 0
117 INT299444 Foxl2 Positive_regulation of Sirt1 1 0.24 0.31 0
118 INT289600 Negative_regulation of Binding of Sirt1 and Sirt1 1 0.47 1.17 0
119 INT299458 Gene_expression of Sirt1 Negative_regulation of Foxl2 1 0.25 0.32 0
120 INT269586 Negative_regulation of TMPO Positive_regulation of RHOA 1 0.14 0 0
121 INT269937 Binding of Smad3 and Mgst1 1 0.09 0 0
122 INT204325 Binding of PPARGC1A and SIRT1 1 0.39 0.19 0
123 INT350098 Gene_expression of PSEN2 Positive_regulation of Gene_expression of Hmox1 1 0.39 0 0
124 INT273289 Binding of Psen2 and Ryr2 1 0.27 4.53 0
125 INT269919 Sox17 Negative_regulation of Binding of Smad3 1 0.36 0 0
126 INT269552 TMPO Regulation of Localization of CA2 1 0.11 0 0
127 INT314965 Binding of Lbr and Blvrb 1 0.00 0.13 0
128 INT244458 CS Positive_regulation of ERN1 1 0.17 0.71 0
129 INT289534 Sirt1 Regulation of Regulation of Pomc 1 0.04 0.15 0
130 INT314971 Binding of ITGAX and Lbr 1 0.05 0.07 0
131 INT269924 Smad3 Regulation of Gene_expression of Cdkn2b 1 0.23 0.26 0
132 INT256165 Binding of Sirt6 and Sirt1 1 0.13 0.58 0
133 INT244459 ERN1 Regulation of Positive_regulation of MAPK8 1 0.03 0.47 0
134 INT269955 Positive_regulation of Binding of Smad3 and Sox17 1 0.39 0.05 0
135 INT318218 SIRT1 Positive_regulation of Binding of FOXO3 1 0.44 0.51 0
136 INT217398 Binding of Psen2 and Bace1 1 0.12 1.44 0
137 INT315534 Binding of ACO1 and ERN1 1 0.01 0.18 0
138 INT289518 Arc Regulation of Sirt1 1 0.10 0.56 0
139 INT329746 ENG Positive_regulation of SMAD1 1 0.15 0.44 0
140 INT254863 Tgfb1 Positive_regulation of Transcription of Smad3 1 0.03 0.23 0
141 INT324053 Binding of Banf1 and Lemd3 1 0.20 0.15 0
142 INT289537 Lep Negative_regulation of Sirt1 1 0.20 0.05 0
143 INT318219 SIRT1 Regulation of TBK1 1 0.03 0.43 0
144 INT314966 Binding of Lbr and H2 1 0.01 0.07 0
145 INT193955 Binding of Psen1 and Psen2 1 0.37 1.64 0
146 INT254857 Tgfb1 Positive_regulation of Phosphorylation of Smad3 1 0.03 0.44 0
147 INT269580 TMPO Positive_regulation of GOPC 1 0.05 0 0
148 INT289517 Sirt1 Regulation of Prkag1 1 0.02 0.08 0
149 INT204326 SIRT1 Positive_regulation of PPARGC1A 1 0.51 0.19 0
150 INT318221 SIRT1 Positive_regulation of FOXO3 1 0.41 0.63 0
151 INT269921 Binding of Smad3 and Scn4a 1 0.12 0 0
152 INT314970 Binding of Cd40 and Lbr 1 0.03 0.07 0
153 INT337637 SIRT1 Negative_regulation of TP53 1 0.23 1.49 0
154 INT269565 Binding of TMPO and MAPKAP1 1 0.02 0.06 0
155 INT292389 Binding of Itpr1 and Mrvi1 1 0.16 0.05 0
156 INT269553 TMPO Regulation of PTGIR 1 0.01 0 0
157 INT289598 Binding of Sirt1 and Sirt1 1 0.41 1.15 0
158 INT269942 Sox17 Regulation of Smad3 1 0.37 0.12 0
159 INT218665 Olr811 Negative_regulation of Phosphorylation of Smad3 1 0.01 0.33 0
160 INT269588 PRKG1 Positive_regulation of Phosphorylation of TMPO 1 0.11 0 0
161 INT244481 Binding of ERN1 and ATF6 1 0.17 0.69 0
162 INT269929 Binding of Cdkn2b and Smad3 1 0.18 0.89 0
163 INT269935 Binding of Smad3 and Scn5a 1 0.13 0 0
164 INT300307 Binding of Tp53 and Sirt1 1 0.24 0.98 0
165 INT269930 Binding of Smad3 and Sox17 1 0.40 1.16 0
166 INT289519 Sirt1 Regulation of Rps6kb1 1 0.25 0.13 0
167 INT269590 Positive_regulation of TMPO Positive_regulation of RHOA 1 0.16 0 0
168 INT289530 Sirt1 Regulation of Foxo1 1 0.25 0.42 0
169 INT289523 Binding of Foxo1 and Positive_regulation of Sirt1 1 0.36 0.13 0
170 INT269583 TMPO Positive_regulation of Gene_expression of RHOA 1 0.16 0.14 0
171 INT204321 NOS3 Regulation of SIRT1 1 0.23 0.1 0
172 INT314132 Sirt1 Positive_regulation of Ppargc1a 1 0.50 2.3 0
173 INT299451 Foxl2 Negative_regulation of Gene_expression of Sirt1 1 0.25 0.32 0
174 INT314969 Binding of Lbr and Mthfd1 1 0.01 0 0
175 INT269550 TMPO Positive_regulation of Phosphorylation of PRKG1 1 0.11 0 0
176 INT289531 Acsm3 Positive_regulation of Sirt1 1 0.01 0.27 0
177 INT269574 Regulation of TMPO Positive_regulation of RHOA 1 0.20 0 0
178 INT294428 PSEN2 Regulation of Gene_expression of Tp53 1 0.49 0.86 0
179 INT269560 TMPO Regulation of Phosphorylation of CFL1 1 0.07 0 0
180 INT314964 Binding of Cd86 and Lbr 1 0.03 0.07 0
181 INT294429 PSEN2 Negative_regulation of Tp53 1 0.46 1.03 0
182 INT193957 Binding of Bcl2l1 and Psen2 1 0.07 0.66 0
183 INT331479 Binding of PSEN2 and Psen1 1 0.00 0.07 0
184 INT269595 TMPO Positive_regulation of Phosphorylation of CFL1 1 0.07 0 0
185 INT269559 PTGIR Regulation of Phosphorylation of TMPO 1 0.01 0.06 0
186 INT292385 Binding of Itpr1 and Lrmp 1 0.17 0.05 0
187 INT318216 SIRT1 Positive_regulation of Gene_expression of FOXO3 1 0.36 0.52 0
188 INT318217 SIRT1 Regulation of TP53 1 0.07 0.43 0
189 INT209986 Binding of HSD11B1 and SIGMAR1 1 0.00 0.1 0
190 INT269946 Binding of Smad3 and Gopc 1 0.08 0 0
191 INT269563 GOPC Positive_regulation of Gene_expression of TMPO 1 0.05 0 0
192 INT268344 SMAD3 Positive_regulation of SMAD4 1 0.17 0.56 0
193 INT269577 Binding of PTGIR and TMPO 1 0.01 0 0
194 INT269582 Negative_regulation of TMPO Positive_regulation of PTGDS 1 0.06 0 0
195 INT204319 SIRT1 Regulation of Gene_expression of PPARGC1A 1 0.50 0.12 0
196 INT269558 Gene_expression of PRKG1 Positive_regulation of Phosphorylation of TMPO 1 0.11 0 0
197 INT289535 Negative_regulation of Sirt1 Negative_regulation of Binding of Foxo1 1 0.29 0.14 0
198 INT289529 Lep Regulation of Sirt1 1 0.28 0.19 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for nuclear inner membrane. They are ordered first by their pain relevance and then by number of times they were reported in nuclear inner membrane. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT1715 Positive_regulation of Nrm 51 0.70 24 47.53
2 INT41230 Gene_expression of Nrm 16 0.67 6.37 21.67
3 INT12837 Binding of SIGMAR1 57 0.48 5.31 15.49
4 INT20715 Binding of Sigmar1 45 0.48 4.03 13.17
5 INT3770 Negative_regulation of Nrm 13 0.43 3.55 12.83
6 INT1663 Regulation of Nrm 12 0.55 2.73 12.73
7 INT39244 Gene_expression of TMPO 137 0.77 14.55 11.83
8 INT13338 Regulation of Sigmar1 22 0.57 2.91 11.35
9 INT39242 Negative_regulation of TMPO 29 0.58 5.15 7.04
10 INT12838 Gene_expression of SIGMAR1 30 0.78 3.52 6.81
11 INT60724 Gene_expression of Psen2 30 0.72 27 5.79
12 INT25242 Positive_regulation of Sigmar1 17 0.66 3.93 5.65
13 INT4613 Positive_regulation of Sirt1 32 0.67 18.19 5.53
14 INT5978 Positive_regulation of SIGMAR1 13 0.42 0.72 5.35
15 INT83728 Localization of TMPO 42 0.46 0.46 5.06
16 INT44745 Localization of Nrm 5 0.65 2.04 4.92
17 INT240934 Gene_expression of Sirt1 24 0.75 18.77 4.68
18 INT178751 Positive_regulation of TMPO 51 0.44 1.47 4.41
19 INT64668 Regulation of SIGMAR1 13 0.60 0.54 3.91
20 INT91761 Gene_expression of PSEN2 38 0.75 22.93 3.03
21 INT48106 Positive_regulation of LBR 11 0.49 5.14 2.86
22 INT13600 Binding of Nrm 4 0.36 2.32 2.79
23 INT11139 Gene_expression of LBR 20 0.75 5.13 2.78
24 INT39243 Regulation of TMPO 20 0.61 5.66 2.67
25 INT29064 Gene_expression of Sigmar1 9 0.77 2.48 2.65
26 INT269402 Phosphorylation of TMPO 17 0.32 0.17 2.36
27 INT269372 Positive_regulation of Localization of TMPO 19 0.23 0.25 2.23
28 INT221409 Regulation of Sirt1 8 0.58 5.53 2.1
29 INT44773 Negative_regulation of LBR 6 0.57 2.32 2.03
30 INT60723 Localization of Psen2 5 0.68 2.11 2.02
31 INT40479 Negative_regulation of SIGMAR1 6 0.52 1.26 1.88
32 INT107332 Negative_regulation of Regulation of Sigmar1 1 0.19 0 1.86
33 INT95544 Negative_regulation of Itpr1 4 0.59 1.6 1.85
34 INT269406 Binding of TMPO 35 0.31 1.43 1.82
35 INT61890 Localization of SIGMAR1 6 0.40 0.3 1.52
36 INT25241 Negative_regulation of Sigmar1 10 0.56 2.97 1.5
37 INT255787 Positive_regulation of Gene_expression of Sirt1 9 0.67 7.61 1.5
38 INT289575 Gene_expression of Sirt1 47 0.77 29.29 1.47
39 INT42427 Negative_regulation of Regulation of Nrm 2 0.18 0.66 1.47
40 INT78646 Regulation of Psen2 4 0.20 1.78 1.42
41 INT99158 Positive_regulation of Positive_regulation of Nrm 2 0.41 1.51 1.37
42 INT269381 Positive_regulation of Phosphorylation of TMPO 9 0.20 0 1.27
43 INT162467 Gene_expression of ERN1 10 0.56 5.11 1.26
44 INT26153 Localization of Sigmar1 4 0.80 0.1 1.26
45 INT34258 Regulation of Negative_regulation of Nrm 1 0.23 0.18 1.25
46 INT269411 Positive_regulation of Gene_expression of TMPO 9 0.23 0.65 1.22
47 INT37831 Negative_regulation of Negative_regulation of Nrm 1 0.43 0.23 1.2
48 INT28643 Positive_regulation of Gene_expression of LBR 3 0.11 2.43 1.16
49 INT243729 Localization of Itpr1 2 0.05 0.37 1.16
50 INT31805 Localization of LBR 3 0.73 1.23 1.13
51 INT184720 Negative_regulation of Smad3 8 0.55 5.23 1.1
52 INT262550 Negative_regulation of Localization of Itpr1 1 0.03 0.37 1.09
53 INT162471 Positive_regulation of ERN1 7 0.34 3.02 1.08
54 INT289553 Positive_regulation of Gene_expression of Sirt1 21 0.69 20.43 1.03
55 INT106690 Positive_regulation of Gene_expression of SIGMAR1 5 0.61 0.12 1.03
56 INT71378 Transcription of LBR 2 0.07 1.34 1.03
57 INT160899 Positive_regulation of Gene_expression of Nrm 1 0.38 0.65 1.03
58 INT168065 Binding of Sirt1 13 0.47 4.55 1.02
59 INT78645 Negative_regulation of Gene_expression of Psen2 1 0.14 0.13 1.01
60 INT70604 Positive_regulation of Positive_regulation of Sigmar1 2 0.50 0 0.98
61 INT269384 Negative_regulation of Gene_expression of TMPO 10 0.23 0.47 0.97
62 INT162464 Positive_regulation of Gene_expression of ERN1 2 0.36 1.66 0.97
63 INT44772 Negative_regulation of Negative_regulation of LBR 2 0.42 0.38 0.92
64 INT26326 Regulation of Binding of Sigmar1 4 0.27 0.66 0.9
65 INT107333 Regulation of Regulation of Sigmar1 1 0.27 0 0.9
66 INT269413 Regulation of Localization of TMPO 7 0.18 0 0.86
67 INT140794 Gene_expression of Smad3 22 0.64 9.41 0.83
68 INT151532 Regulation of Itpr1 2 0.01 0.63 0.83
69 INT78647 Positive_regulation of Localization of Psen2 1 0.16 0.14 0.83
70 INT289550 Positive_regulation of Sirt1 25 0.69 13.59 0.8
71 INT269401 Regulation of Gene_expression of TMPO 8 0.18 2.89 0.78
72 INT161047 Negative_regulation of Positive_regulation of Nrm 1 0.37 1.24 0.78
73 INT94756 Positive_regulation of PSEN2 8 0.49 4.59 0.77
74 INT75712 Gene_expression of Itpr1 3 0.59 1.89 0.77
75 INT193849 Positive_regulation of Gene_expression of Psen2 5 0.44 4.92 0.76
76 INT78649 Binding of Psen2 7 0.36 5.9 0.73
77 INT78648 Regulation of Binding of Psen2 1 0.14 0.2 0.73
78 INT151217 Phosphorylation of SIGMAR1 2 0.04 0.41 0.72
79 INT47853 Negative_regulation of Gene_expression of Nrm 1 0.43 0.23 0.67
80 INT51976 Positive_regulation of Regulation of Nrm 1 0.41 0.1 0.65
81 INT46148 Binding of LBR 5 0.31 1.58 0.64
82 INT91765 Positive_regulation of Gene_expression of PSEN2 8 0.49 4.57 0.63
83 INT103199 Positive_regulation of Positive_regulation of SIGMAR1 2 0.13 0.15 0.62
84 INT61506 Localization of Ghrhr 1 0.51 0 0.61
85 INT307027 Positive_regulation of Localization of LBR 1 0.05 0.82 0.61
86 INT269379 Negative_regulation of Localization of TMPO 5 0.17 0 0.56
87 INT176375 Positive_regulation of Positive_regulation of LBR 1 0.10 1.12 0.53
88 INT63458 Negative_regulation of Binding of Sigmar1 2 0.36 0.39 0.52
89 INT269414 Regulation of Phosphorylation of TMPO 5 0.18 0.11 0.51
90 INT54594 Regulation of Positive_regulation of Nrm 1 0.12 0.26 0.49
91 INT289580 Negative_regulation of Sirt1 23 0.58 9.03 0.48
92 INT154708 Gene_expression of Rnf13 1 0.67 3.27 0.45
93 INT316041 Transcription of Psen2 1 0.64 1.1 0.45
94 INT300291 Phosphorylation of Sirt1 1 0.77 6.07 0.45
95 INT240935 Transcription of Sirt1 2 0.68 0.42 0.42
96 INT340290 Regulation of Transcription of Sirt1 1 0.43 0.13 0.42
97 INT285501 Gene_expression of Smad1 6 0.42 3.09 0.41
98 INT36396 Positive_regulation of Psen2 6 0.44 4.57 0.39
99 INT61891 Positive_regulation of Binding of SIGMAR1 2 0.32 0.34 0.39
100 INT21831 Positive_regulation of Lbr 2 0.37 0 0.39
101 INT311882 Negative_regulation of Smad1 1 0.25 0.99 0.39
102 INT269373 Positive_regulation of Positive_regulation of TMPO 3 0.20 0.06 0.38
103 INT218691 Phosphorylation of Smad3 1 0.28 3 0.38
104 INT157804 Phosphorylation of Smad3 18 0.77 8.15 0.35
105 INT3044 Regulation of LBR 2 0.44 0.1 0.35
106 INT240914 Negative_regulation of Sirt1 9 0.46 3.16 0.34
107 INT261682 Positive_regulation of Positive_regulation of PSEN2 1 0.21 0.55 0.33
108 INT181918 Positive_regulation of SMAD3 6 0.35 2.62 0.31
109 INT289546 Negative_regulation of Gene_expression of Sirt1 5 0.42 3.1 0.31
110 INT204368 Gene_expression of SIRT1 17 0.76 4.48 0.3
111 INT140795 Positive_regulation of Gene_expression of Smad3 3 0.48 3.16 0.3
112 INT269367 Regulation of Negative_regulation of TMPO 3 0.18 0 0.29
113 INT107163 Negative_regulation of Lbr 1 0.15 0 0.29
114 INT224298 Negative_regulation of PSEN2 6 0.57 2.29 0.28
115 INT244537 Regulation of ERN1 3 0.26 1.32 0.25
116 INT262797 Regulation of Gene_expression of Smad3 2 0.34 2.27 0.25
117 INT172525 Localization of PSEN2 5 0.73 4.17 0.24
118 INT21829 Regulation of Lbr 1 0.04 0 0.24
119 INT63457 Positive_regulation of Gene_expression of Sigmar1 1 0.36 0.09 0.23
120 INT154709 Positive_regulation of Gene_expression of Rnf13 1 0.35 1.65 0.22
121 INT120202 Gene_expression of Ern1 2 0.14 1.78 0.21
122 INT269376 Negative_regulation of Phosphorylation of TMPO 2 0.17 0.11 0.21
123 INT289551 Regulation of Sirt1 8 0.61 4.46 0.2
124 INT269394 Negative_regulation of Positive_regulation of TMPO 2 0.17 0.28 0.2
125 INT32051 Localization of Tmpo 1 0.02 0 0.19
126 INT311891 Phosphorylation of Smad1 4 0.51 1.34 0.18
127 INT157797 Negative_regulation of Phosphorylation of Smad3 3 0.40 0.95 0.17
128 INT246620 Negative_regulation of Positive_regulation of Sirt1 2 0.39 1.9 0.17
129 INT269389 Protein_catabolism of TMPO 1 0.06 0 0.15
130 INT310174 Positive_regulation of Smad1 9 0.45 2.16 0.14
131 INT256111 Regulation of Gene_expression of Sirt1 1 0.32 0.73 0.14
132 INT231317 Localization of ERN1 1 0.65 0.45 0.14
133 INT59959 Positive_regulation of Binding of Sigmar1 1 0.47 0.16 0.14
134 INT204365 Positive_regulation of Gene_expression of SIRT1 8 0.68 2.9 0.13
135 INT158903 Gene_expression of Smad3 2 0.56 0.54 0.13
136 INT158890 Negative_regulation of Gene_expression of Smad3 1 0.42 0.13 0.13
137 INT269375 Positive_regulation of Binding of TMPO 1 0.04 0 0.13
138 INT64474 Regulation of Positive_regulation of LBR 1 0.22 0.08 0.13
139 INT18042 Negative_regulation of Binding of SIGMAR1 1 0.12 0 0.13
140 INT269398 Regulation of Binding of TMPO 2 0.18 0 0.12
141 INT269390 Regulation of Positive_regulation of TMPO 6 0.26 0.4 0.11
142 INT289543 Regulation of Gene_expression of Sirt1 3 0.45 1.81 0.11
143 INT289547 Positive_regulation of Positive_regulation of Sirt1 2 0.69 0.76 0.11
144 INT332681 Regulation of Positive_regulation of Sirt1 1 0.16 0.69 0.11
145 INT176595 Negative_regulation of Gene_expression of PSEN2 1 0.24 1.01 0.11
146 INT193841 Regulation of Gene_expression of Psen2 1 0.40 1.66 0.11
147 INT124453 Binding of Itpr1 1 0.33 0 0.11
148 INT324046 Gene_expression of Lemd3 1 0.67 1.69 0.1
149 INT262892 Gene_expression of Ghrhr 1 0.20 1.93 0.1
150 INT244534 Negative_regulation of ERN1 2 0.25 1.08 0.09
151 INT289567 Regulation of Negative_regulation of Sirt1 1 0.45 0.74 0.09
152 INT66203 Regulation of Binding of SIGMAR1 1 0.44 0.19 0.09
153 INT109131 Regulation of PSEN2 3 0.44 0.55 0.08
154 INT55486 Negative_regulation of Positive_regulation of LBR 1 0.41 1.07 0.08
155 INT84943 Regulation of Transcription of SIGMAR1 1 0.03 0.08 0.08
156 INT84942 Transcription of SIGMAR1 1 0.06 0.08 0.08
157 INT269609 Transcription of TMPO 1 0.27 0 0.07
158 INT269616 Positive_regulation of Transcription of TMPO 1 0.20 0 0.07
159 INT289574 Negative_regulation of Positive_regulation of Sirt1 1 0.42 0.42 0.07
160 INT256136 Negative_regulation of Binding of Sirt1 1 0.30 0.5 0.07
161 INT242971 Positive_regulation of Ern1 1 0.04 1.62 0.07
162 INT265317 Negative_regulation of Gene_expression of Smad3 2 0.41 0.9 0.06
163 INT303974 Phosphorylation of LBR 2 0.79 0.24 0.06
164 INT269603 Regulation of Regulation of TMPO 1 0.24 0.45 0.06
165 INT339991 Localization of SIRT1 1 0.34 0.3 0.06
166 INT303973 Negative_regulation of Phosphorylation of LBR 1 0.41 0.14 0.06
167 INT176592 Transcription of PSEN2 5 0.33 0.41 0.05
168 INT256137 Positive_regulation of Regulation of Sirt1 1 0.36 0.32 0.05
169 INT318236 Negative_regulation of Gene_expression of SIRT1 1 0.42 0.59 0.05
170 INT289587 Negative_regulation of Negative_regulation of Sirt1 1 0.42 0.65 0.05
171 INT256129 Negative_regulation of Gene_expression of Sirt1 1 0.31 0.4 0.05
172 INT262799 Localization of Smad3 6 0.56 2.09 0.04
173 INT311890 Binding of Smad1 2 0.23 0.46 0.04
174 INT21830 Localization of Lbr 1 0.14 0 0.04
175 INT269639 Positive_regulation of Negative_regulation of TMPO 1 0.20 0 0.04
176 INT289584 Binding of Sirt1 3 0.48 1.35 0.03
177 INT184722 Positive_regulation of Smad3 3 0.47 1.22 0.03
178 INT270038 Positive_regulation of Positive_regulation of Sirt1 2 0.43 0.44 0.03
179 INT271419 Localization of SMAD3 2 0.11 0.13 0.03
180 INT246622 Phosphorylation of Sirt1 2 0.74 0.56 0.03
181 INT269405 Negative_regulation of Negative_regulation of TMPO 1 0.04 0 0.03
182 INT254812 Positive_regulation of Phosphorylation of Smad3 1 0.25 0.94 0.03
183 INT254805 Transcription of Smad3 1 0.28 0.76 0.03
184 INT242970 Phosphorylation of Ern1 1 0.06 0.86 0.03
185 INT311888 Negative_regulation of Phosphorylation of Smad1 1 0.25 0.48 0.03
186 INT204367 Positive_regulation of SIRT1 13 0.68 4.17 0
187 INT204349 Regulation of SIRT1 8 0.61 1.99 0
188 INT256134 Localization of Sirt1 5 0.50 2.99 0
189 INT204353 Transcription of SIRT1 3 0.68 0.67 0
190 INT224302 Negative_regulation of Transcription of PSEN2 3 0.26 0.08 0
191 INT265229 Binding of PSEN2 2 0.16 1.37 0
192 INT265337 Binding of Smad3 2 0.35 1 0
193 INT269913 Positive_regulation of Binding of Smad3 1 0.34 0.3 0
194 INT306791 Binding of ERN1 1 0.10 0.22 0
195 INT218693 Negative_regulation of Phosphorylation of Smad3 1 0.19 0.32 0
196 INT324047 Binding of Lemd3 1 0.48 3.18 0
197 INT329771 Positive_regulation of SMAD1 1 0.36 2.3 0
198 INT330661 Regulation of Phosphorylation of LBR 1 0.03 0.1 0
199 INT155520 Regulation of Gene_expression of SIGMAR1 1 0.24 0.16 0
200 INT329784 Gene_expression of SMAD3 1 0.31 0.41 0
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