GO:0005654

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Name nucleoplasm
Categary Component
Go Slim Yes
Go Link GO:0005654
Unique Molecular Interactions 4890
Total Molecular Interactions 6557
Total Single Events 48034
Pain Genes Associated 391

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for nucleoplasm. They are ordered first by their pain relevance and then by number of times they were reported for nucleoplasm. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT324068 Binding of GCH1 and SNRNP70 1 0.01 28.19 40.6
2 INT106676 Binding of Trpv1 and Phax 18 0.34 4.19 12.36
3 INT206768 TP53 Positive_regulation of Ltp 2 0.01 5.83 10.21
4 INT132225 Negative_regulation of Binding of Akt1 and Sh2d6 1 0.10 3.92 7.2
5 INT338167 Binding of CDKN2A and MC1R 1 0.42 6.14 5.76
6 INT9546 Binding of Adarb1 and Penk 5 0.03 0 5.1
7 INT61359 TNF Positive_regulation of NFKB1 11 0.63 6.66 3.89
8 INT113080 Drd1a Positive_regulation of Phosphorylation of Creb1 2 0.27 0.43 3.88
9 INT130625 Prkcg Regulation of Prkaca 1 0.23 1.32 3.87
10 INT317511 Ppp1r9b Regulation of Oprm1 3 0.27 0.33 3.85
11 INT107331 Binding of PPBP and Adarb1 1 0.01 0 3.67
12 INT132231 Negative_regulation of Binding of Akt1 and Pik3cg 1 0.34 1.96 3.6
13 INT302118 Binding of Oprm1 and Ppp1r9b 2 0.24 0.26 3.45
14 INT69823 Binding of GHR and RYBP 1 0.01 0 3.23
15 INT128513 Pnoc Regulation of Adarb1 1 0.01 0.92 3.14
16 INT202959 Binding of BAG3 and MCRS1 1 0.11 7.46 3.14
17 INT94204 NCOR2 Regulation of Gene_expression of SP5 1 0.02 2.15 3.12
18 INT161164 Prkcg Regulation of Phosphorylation of Creb1 3 0.41 0.62 3.11
19 INT309150 Edc4 Positive_regulation of Creb1 1 0.03 3.46 3.09
20 INT298456 Prkaca Positive_regulation of Phosphorylation of Adarb1 1 0.00 1.86 2.85
21 INT168758 Hist1h1t Positive_regulation of Phosphorylation of Akt1 2 0.02 0.44 2.79
22 INT190167 Binding of JUN and MMP12 1 0.26 0.82 2.76
23 INT259231 Binding of Oprm1 and Ppp1r9b 1 0.01 0 2.67
24 INT91350 Binding of Pla2g4a and RYBP 1 0.00 1.15 2.65
25 INT223866 Ltp Positive_regulation of Positive_regulation of Mapk1 2 0.46 0.75 2.61
26 INT26892 OGG1 Negative_regulation of Gene_expression of Gh1 1 0.12 0 2.53
27 INT317528 Ppp1r9b Regulation of Grin1 1 0.18 0.2 2.48
28 INT153728 RYBP Positive_regulation of Gpt 3 0.03 2.01 2.36
29 INT106750 Pes1 Negative_regulation of Positive_regulation of Casp3 3 0.23 0 2.35
30 INT121746 Prkaca Positive_regulation of Ephb1 2 0.23 0.92 2.35
31 INT238914 Positive_regulation of CNR1 Positive_regulation of Phosphorylation of MAPK1 1 0.19 3.22 2.35
32 INT121726 Ngf Positive_regulation of Phosphorylation of Akt1 1 0.37 1.4 2.34
33 INT139723 PROC Positive_regulation of MAPK8 1 0.01 2.98 2.33
34 INT156622 Umod Regulation of Phosphorylation of Creb1 1 0.05 0.33 2.27
35 INT106753 Pes1 Negative_regulation of Gene_expression of Casp3 2 0.12 0 2.19
36 INT140659 Phax Positive_regulation of Trpv1 3 0.49 0.68 2.18
37 INT209924 IL1B Negative_regulation of PPARA 1 0.20 4.38 2.17
38 INT184262 Binding of AGER and HMGB1 1 0.34 4.49 2.17
39 INT319581 Binding of PIAS1 and TNFSF14 1 0.02 1.58 2.13
40 INT66157 Binding of ALB and BDP1 1 0.11 0 2.13
41 INT158964 FosB Negative_regulation of Creb1 1 0.21 0 2.07
42 INT114927 Positive_regulation of Binding of Oprm1 and Creb1 1 0.17 0.28 2.07
43 INT281084 Prkaca Positive_regulation of Mapk1 2 0.25 0 2.06
44 INT114923 Binding of Oprm1 and Creb1 1 0.16 0.28 2.06
45 INT167530 Phax Regulation of Gene_expression of Trpv1 1 0.16 0.86 2.05
46 INT124133 Camk2a Regulation of Phosphorylation of Creb1 1 0.46 0 2
47 INT53751 Positive_regulation of Cyp2e1 Positive_regulation of RYBP 1 0.14 0.89 1.98
48 INT164665 Adarb1 Positive_regulation of Negative_regulation of Tens1 1 0.03 0.42 1.97
49 INT129212 RYBP Positive_regulation of Tnf 2 0.03 1.9 1.95
50 INT227493 Binding of TCEA1 and SIRT2 1 0.01 1.55 1.93
51 INT262558 Phax Positive_regulation of Trpv1 1 0.01 1.26 1.92
52 INT30146 Binding of Adarb1 and Pdyn 1 0.01 0.17 1.91
53 INT351281 AP1M2 Regulation of NCOR2 1 0.00 0.85 1.9
54 INT112514 Binding of Prkaca and Trib3 1 0.03 1.18 1.9
55 INT186435 Prkcg Regulation of Creb1 1 0.44 0.45 1.9
56 INT186432 Prkaca Regulation of Creb1 1 0.14 0.45 1.9
57 INT297488 Itpr3 Regulation of Positive_regulation of Ltp 1 0.02 0.47 1.87
58 INT112517 Binding of Ephb1 and Prkaca 3 0.18 0.58 1.85
59 INT81920 Binding of IL1B and NFKB1 1 0.04 1.54 1.85
60 INT81914 Binding of HSF1 and NFKB1 1 0.05 1.54 1.85
61 INT275851 PES1 Negative_regulation of CP 1 0.01 1.96 1.83
62 INT132229 Binding of Akt1 and Sh2d6 1 0.09 0.98 1.8
63 INT116092 TFF2 Positive_regulation of NFKB1 1 0.17 0.06 1.77
64 INT332773 Positive_regulation of Prkaca Positive_regulation of Phosphorylation of Grin1 1 0.04 0.73 1.75
65 INT92369 Binding of CYP2D6 and RYBP 1 0.25 0.15 1.73
66 INT94203 SP5 Positive_regulation of FOS 1 0.25 1.41 1.72
67 INT186433 Trib3 Regulation of Phosphorylation of Creb1 1 0.03 0.32 1.71
68 INT148090 Binding of CALCA and NCOR2 1 0.00 0.65 1.71
69 INT324067 Regulation of Binding of GCH1 and SNRNP70 1 0.01 0.95 1.67
70 INT149680 Binding of Parp1 and Oprm1 1 0.53 0 1.66
71 INT151889 Binding of Adarb1 and DLL1 1 0.00 0 1.66
72 INT347396 RYBP Positive_regulation of Binding of Sdcbp 1 0.00 0.92 1.66
73 INT322412 PPBP Negative_regulation of Phosphorylation of Akt1 1 0.01 0 1.65
74 INT67966 Cck Positive_regulation of Adarb1 2 0.03 0 1.63
75 INT122286 Prkaca Negative_regulation of Negative_regulation of Calca 1 0.12 0.54 1.63
76 INT135516 PRKCA Negative_regulation of Phosphorylation of OPRM1 1 0.12 0 1.62
77 INT94033 Binding of Adarb1 and SLAMF6 1 0.01 0 1.61
78 INT73116 TYMS Negative_regulation of DNMT3B 1 0.24 0 1.6
79 INT73115 TYMS Negative_regulation of Positive_regulation of DNMT3B 1 0.24 0 1.6
80 INT105112 Plat Positive_regulation of JUN 1 0.01 1.55 1.58
81 INT149632 Binding of HK1 and NCOR2 1 0.01 0.13 1.58
82 INT118515 Positive_regulation of PRKCA Positive_regulation of Phosphorylation of TRPV1 1 0.27 0.56 1.58
83 INT128512 Regulation of Pnoc Regulation of Adarb1 1 0.01 0.46 1.58
84 INT131574 Negative_regulation of Ephb1 Negative_regulation of Gene_expression of Creb1 1 0.41 0.33 1.58
85 INT144280 ACP1 Negative_regulation of Phosphorylation of MAPK1 1 0.37 0.78 1.56
86 INT347397 RYBP Positive_regulation of Sdcbp 1 0.00 0.22 1.56
87 INT116093 OPRM1 Positive_regulation of Positive_regulation of NFKB1 1 0.36 0.08 1.56
88 INT114926 Creb1 Negative_regulation of Positive_regulation of Oprm1 1 0.13 0.23 1.56
89 INT106751 Pes1 Negative_regulation of Casp3 2 0.23 0 1.54
90 INT100784 RYBP Positive_regulation of CYP3A4 1 0.44 0 1.54
91 INT121747 Prkcg Negative_regulation of Positive_regulation of Creb1 1 0.16 0.2 1.5
92 INT166676 Binding of PRKCA and UGT1A6 1 0.30 0 1.5
93 INT121741 Prkaca Negative_regulation of Positive_regulation of Creb1 1 0.10 0.2 1.49
94 INT340300 Ea1 Positive_regulation of Gene_expression of Sirt1 1 0.08 1.68 1.49
95 INT27932 Binding of CCK and NCOR2 1 0.01 0.91 1.47
96 INT73650 Binding of Pim3 and Creb1 1 0.03 2.48 1.47
97 INT169800 Negative_regulation of Adrbk1 Positive_regulation of Positive_regulation of Mapk1 1 0.39 1.04 1.45
98 INT72319 Adarb1 Positive_regulation of Gene_expression of Fos 3 0.10 0.1 1.44
99 INT202958 Binding of STC2 and MCRS1 1 0.01 3.48 1.44
100 INT214372 Ptprq Positive_regulation of Akt1 1 0.04 0.88 1.43
101 INT261831 Mapk1 Negative_regulation of Hspg2 1 0.00 1.26 1.42
102 INT148450 Gene_expression of Inhbe Positive_regulation of Mapk1 1 0.07 1.35 1.41
103 INT161670 H2-M3 Positive_regulation of Positive_regulation of Mapk1 1 0.14 0.73 1.41
104 INT298458 Binding of Calcrl and Adarb1 1 0.00 0.23 1.41
105 INT214369 Pik3cb Positive_regulation of Akt1 1 0.56 0.87 1.41
106 INT78974 Binding of Prkcg and Prkaca 2 0.31 0.35 1.4
107 INT134679 FSCN1 Positive_regulation of MAPK8 1 0.01 0.56 1.39
108 INT73377 Npy Regulation of Adarb1 2 0.03 0.15 1.38
109 INT29599 Binding of Cyp21a1 and Adarb1 1 0.01 0 1.38
110 INT50706 Phax Positive_regulation of Localization of Trib3 1 0.04 0.28 1.38
111 INT168724 Creb1 Negative_regulation of Gene_expression of Calca 1 0.46 1.09 1.38
112 INT26893 OGG1 Negative_regulation of Gh1 1 0.12 0 1.37
113 INT168721 Positive_regulation of Creb1 Positive_regulation of Calca 1 0.53 1.07 1.37
114 INT106850 P2ry2 Positive_regulation of Phosphorylation of Creb1 2 0.49 0.73 1.36
115 INT117871 Sct Positive_regulation of Pes1 1 0.10 0 1.36
116 INT168722 Creb1 Positive_regulation of Calca 1 0.73 1.05 1.35
117 INT106062 Positive_regulation of Oprl1 Positive_regulation of Mapk1 1 0.13 0.16 1.35
118 INT222182 Binding of ESR1 and HLA-DRB2 1 0.00 3.1 1.35
119 INT106071 Positive_regulation of Oprl1 Positive_regulation of MAPK3 1 0.12 0.16 1.34
120 INT259211 Binding of Ppp1r9b and Flna 1 0.06 0 1.33
121 INT94630 Positive_regulation of Adarb1 Positive_regulation of Gene_expression of Fos 2 0.03 0.1 1.32
122 INT131886 Creb1 Positive_regulation of Gene_expression of Prkcg 1 0.03 0 1.31
123 INT112097 Sstr1 Positive_regulation of Adarb1 1 0.02 0.15 1.29
124 INT113844 CDKN1A Negative_regulation of CDK2 4 0.49 1.18 1.27
125 INT136644 T(1;9)27H Negative_regulation of Gene_expression of Hand1 1 0.15 1.14 1.27
126 INT70181 PRCP Positive_regulation of FOS 1 0.58 0.36 1.26
127 INT124099 Binding of GGT5 and RYBP 1 0.00 0.34 1.26
128 INT84886 APC Regulation of PPARD 1 0.51 1.57 1.26
129 INT124108 Binding of RYBP and Ccne1 1 0.09 0.34 1.26
130 INT139724 PROC Positive_regulation of MAPK14 1 0.00 1.57 1.25
131 INT116892 Binding of TRPV1 and Phax 4 0.00 0.1 1.24
132 INT162163 CDKN2A Positive_regulation of PLD2 1 0.24 0 1.24
133 INT136250 Phosphorylation of Tff3 Regulation of Creb1 1 0.02 0.18 1.24
134 INT141244 Fos Regulation of Prkaca 1 0.18 0.07 1.24
135 INT136256 Creb1 Regulation of SGCG 1 0.26 0.18 1.23
136 INT136258 Creb1 Regulation of GRIA1 1 0.26 0.18 1.23
137 INT83422 Binding of FANCB and IGHG3 3 0.12 5.09 1.22
138 INT131195 Creb1 Positive_regulation of Positive_regulation of Drd1a 2 0.27 0.61 1.22
139 INT166388 Binding of Gnb2l1 and Mapk1 1 0.49 0.49 1.21
140 INT209926 IL1B Regulation of PPARA 1 0.21 2.45 1.2
141 INT133046 TNF Positive_regulation of Positive_regulation of NFKB1 5 0.54 3.23 1.19
142 INT298454 Prkcg Positive_regulation of Phosphorylation of Adarb1 1 0.00 0.41 1.19
143 INT109380 Binding of Adarb1 and Fos 1 0.02 0.38 1.19
144 INT139736 Htr1a Positive_regulation of Mapk3 1 0.54 0.13 1.19
145 INT351715 Pax3 Negative_regulation of Adarb1 1 0.00 0 1.19
146 INT55162 Binding of NFKB1 and RELA 10 0.30 2.82 1.18
147 INT330379 Gene_expression of IL10 Negative_regulation of Positive_regulation of MAPK14 1 0.00 1.95 1.18
148 INT121191 KCNMA1 Positive_regulation of Phosphorylation of MAPK1 1 0.06 0.61 1.18
149 INT261617 SNRNP70 Regulation of Comt 1 0.01 0.4 1.18
150 INT73075 Adarb1 Regulation of Fos 1 0.01 0.07 1.18
151 INT32871 Binding of Insrr and Adarb1 1 0.01 0 1.18
152 INT141245 Prkaca Regulation of Gene_expression of Th 1 0.15 0.17 1.17
153 INT85780 Prkaca Regulation of Prkcg 1 0.29 0.47 1.17
154 INT25112 RYBP Negative_regulation of Binding of PLEKHM1 1 0.01 0 1.17
155 INT169557 Cacna1h Positive_regulation of Mapk1 1 0.07 0.91 1.17
156 INT124435 Gene_expression of Chrna9 Positive_regulation of Phosphorylation of Creb1 1 0.11 0.6 1.17
157 INT238916 CNR1 Positive_regulation of Phosphorylation of MAPK1 1 0.19 1.61 1.17
158 INT150191 CEACAM3 Positive_regulation of Gene_expression of FOS 1 0.34 0.14 1.16
159 INT161510 Tlr4 Positive_regulation of Mapk1 1 0.14 0.3 1.16
160 INT125696 Binding of OPRM1 and SNRNP70 1 0.06 0.99 1.15
161 INT147447 ADCYAP1 Regulation of Localization of RELA 1 0.50 1.12 1.15
162 INT147448 ADCYAP1 Regulation of Localization of NFKB1 1 0.47 1.12 1.15
163 INT69824 Negative_regulation of Binding of GHR and RYBP 1 0.01 0 1.14
164 INT130627 Gnas Regulation of Prkaca 1 0.00 0 1.13
165 INT202960 Binding of MCRS1 and CPP 1 0.14 2.49 1.13
166 INT160540 Binding of NGF and PSIP1 2 0.29 1.43 1.12
167 INT323175 PRKCA Positive_regulation of Akt1 1 0.02 0 1.1
168 INT101715 PLAT Positive_regulation of NFKB1 2 0.11 0.99 1.09
169 INT167429 Negative_regulation of Mapk8 Negative_regulation of RYBP 1 0.01 1.11 1.09
170 INT168303 Binding of SNRPB and UGT2B7 1 0.20 0 1.09
171 INT283934 Phax Negative_regulation of Positive_regulation of Mapk14 1 0.03 2.06 1.09
172 INT164378 MAPK3 Positive_regulation of Transcription of PDYN 1 0.50 0.2 1.09
173 INT108547 AKT1 Regulation of MAPKAPK5 1 0.04 1.2 1.08
174 INT21331 Binding of Adarb1 and Gm5195 1 0.00 0.26 1.08
175 INT33338 Adarb1 Positive_regulation of Localization of Gh1 1 0.04 0 1.08
176 INT28186 CYP2E1 Regulation of Positive_regulation of RYBP 1 0.04 0.33 1.08
177 INT202968 Binding of MCRS1 and CAP1 1 0.03 2.46 1.08
178 INT52076 Binding of RYBP and Abt1 1 0.01 0.28 1.08
179 INT164382 MAPK3 Positive_regulation of Gene_expression of Fos 1 0.75 0.2 1.08
180 INT33336 Adarb1 Positive_regulation of Negative_regulation of Gh1 1 0.03 0 1.08
181 INT164383 Positive_regulation of MAPK3 Positive_regulation of Gene_expression of Fos 1 0.54 0.2 1.08
182 INT96906 Plxna3 Regulation of Regulation of Prkaca 1 0.17 0.71 1.08
183 INT33337 Adarb1 Positive_regulation of Gh1 1 0.03 0 1.08
184 INT121089 Binding of Oprd1 and Adarb1 2 0.06 0 1.07
185 INT132701 Adarb1 Negative_regulation of Gene_expression of Fos 1 0.01 0.73 1.07
186 INT156462 Creb1 Regulation of Ephb1 1 0.29 0 1.07
187 INT105113 Plat Positive_regulation of NFKB1 1 0.03 1.06 1.06
188 INT105109 Cxcl12 Positive_regulation of JUN 1 0.01 1.07 1.05
189 INT97013 Negative_regulation of Binding of CALM3 and OPRM1 1 0.40 0 1.05
190 INT57509 Trh Negative_regulation of Adarb1 1 0.02 0.22 1.05
191 INT57508 Pomc Negative_regulation of Adarb1 1 0.01 0.22 1.05
192 INT97011 Binding of CALM3 and OPRM1 1 0.35 0 1.05
193 INT133072 GATA3 Positive_regulation of Transcription of OPRM1 1 0.35 0 1.04
194 INT352456 Dusp1 Negative_regulation of Mapk14 1 0.03 1.31 1.03
195 INT118859 GNA14 Positive_regulation of STAT3 1 0.01 0.38 1.03
196 INT156245 NFKB1 Positive_regulation of Regulation of TNF 1 0.45 0.76 1.03
197 INT101067 MAP3K15 Positive_regulation of MAPK1 1 0.21 0.47 1.03
198 INT225158 Binding of CDK2 and CDKN1A 7 0.30 3.26 1.02
199 INT160541 Binding of BDNF and PSIP1 4 0.49 1.94 1.02
200 INT74027 Creb1 Regulation of Jun 4 0.27 1.04 1.02

Single Events

The table below shows the top 100 pain related interactions that have been reported for nucleoplasm. They are ordered first by their pain relevance and then by number of times they were reported in nucleoplasm. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT11009 Phosphorylation of Creb1 458 0.82 111.34 221.97
2 INT95787 Positive_regulation of Mapk1 568 0.70 226.51 220.94
3 INT6665 Gene_expression of FOS 520 0.77 165.31 217.66
4 INT11012 Positive_regulation of Creb1 258 0.70 84.4 132
5 INT12501 Positive_regulation of Adarb1 166 0.58 36.94 118.92
6 INT11011 Positive_regulation of Phosphorylation of Creb1 190 0.70 49.25 112.01
7 INT49651 Gene_expression of Creb1 276 0.78 114.77 111.96
8 INT52651 Positive_regulation of Prkaca 136 0.67 40.82 99.16
9 INT17459 Positive_regulation of Gene_expression of FOS 182 0.67 53.45 96.38
10 INT86024 Gene_expression of PPARA 736 0.78 497.93 91.14
11 INT6214 Negative_regulation of Adarb1 123 0.50 26.39 89.57
12 INT71789 Positive_regulation of MAPK1 396 0.70 234.44 89.27
13 INT54571 Positive_regulation of NFKB1 263 0.70 138.99 87.32
14 INT22967 Positive_regulation of RYBP 94 0.56 37.04 85.92
15 INT92434 Phosphorylation of Mapk1 287 0.82 91.65 83.46
16 INT49111 Negative_regulation of Prkaca 102 0.59 27.44 71.77
17 INT4637 Binding of Adarb1 132 0.41 14.48 67.76
18 INT822 Gene_expression of ESR1 529 0.78 302.16 63.64
19 INT67614 Positive_regulation of PPARA 438 0.68 293.28 63.61
20 INT48934 Positive_regulation of Mapk1 157 0.70 60.61 61.72
21 INT18883 Negative_regulation of RYBP 53 0.56 21.14 57.52
22 INT5356 Positive_regulation of FOS 153 0.69 54.21 56.74
23 INT17458 Negative_regulation of Gene_expression of FOS 98 0.57 36.77 55.69
24 INT20375 Gene_expression of Hand1 213 0.60 148.51 54.53
25 INT117713 Phosphorylation of Akt1 275 0.82 95.82 54.34
26 INT48642 Positive_regulation of TCEA1 92 0.70 24.59 53.64
27 INT6165 Gene_expression of Adarb1 85 0.58 18.39 51.03
28 INT40777 Positive_regulation of Akt1 163 0.69 59.41 49.43
29 INT48718 Positive_regulation of PRKCA 109 0.69 36.16 46.49
30 INT4656 Localization of RYBP 49 0.77 5.28 46.21
31 INT71786 Phosphorylation of MAPK1 256 0.82 110.09 46.17
32 INT88617 Positive_regulation of Gene_expression of Creb1 90 0.69 51.69 44.29
33 INT11180 Binding of RYBP 52 0.46 13.86 42.53
34 INT92437 Positive_regulation of Phosphorylation of Mapk1 113 0.70 32.19 40.29
35 INT114751 Gene_expression of Mapk1 137 0.76 60.14 39.98
36 INT11560 Positive_regulation of CASP3 236 0.70 184.33 39.38
37 INT102611 Negative_regulation of Positive_regulation of Mapk1 74 0.58 35.57 39.37
38 INT48933 Gene_expression of Mapk3 93 0.75 44.39 37.92
39 INT18774 Gene_expression of RYBP 67 0.65 47.66 37.59
40 INT80690 Positive_regulation of MAPK8 223 0.68 125.63 36.75
41 INT9082 Positive_regulation of ESR1 238 0.69 148.51 36.69
42 INT72651 Gene_expression of TH1L 114 0.75 80.15 35.15
43 INT103094 Binding of PPARA 308 0.47 177.26 34.75
44 INT11013 Negative_regulation of Phosphorylation of Creb1 55 0.59 18.74 34.66
45 INT67613 Positive_regulation of PPARG 94 0.70 69.15 34.38
46 INT109434 Phosphorylation of Mapk1 110 0.82 61.64 34.05
47 INT48924 Positive_regulation of Mapk3 107 0.67 50.53 34.05
48 INT16714 Regulation of Creb1 64 0.62 22.23 33.56
49 INT48925 Gene_expression of Mapk1 95 0.74 42.21 32.91
50 INT89055 Phosphorylation of Prkaca 60 0.61 13.41 32.49
51 INT117112 Negative_regulation of Mapk1 87 0.56 40.34 31.18
52 INT23222 Binding of Phax 52 0.31 7.61 30.4
53 INT72923 Positive_regulation of MCRS1 72 0.50 99.19 30.36
54 INT72375 Phosphorylation of Mapk3 87 0.80 43.66 30.27
55 INT12502 Regulation of Adarb1 50 0.53 7.58 30.01
56 INT169180 Binding of SNRNP70 204 0.47 119.1 29.3
57 INT11010 Regulation of Phosphorylation of Creb1 52 0.62 7.26 29.04
58 INT6855 Binding of NCOR2 71 0.41 15.64 28.96
59 INT28361 Gene_expression of TP53 443 0.78 384.86 28.8
60 INT52712 Negative_regulation of PRKCA 64 0.57 23.11 28.43
61 INT56072 Negative_regulation of NFKB1 94 0.59 53.16 28.19
62 INT83708 Negative_regulation of MAPK1 156 0.57 84.93 27.85
63 INT112707 Negative_regulation of Akt1 89 0.59 28.85 27.76
64 INT5206 Gene_expression of AR 316 0.78 113.83 27.29
65 INT17331 Positive_regulation of JUN 132 0.69 60.4 27.03
66 INT20462 Binding of ESR1 210 0.44 102.7 26.34
67 INT48979 Regulation of Gene_expression of FOS 52 0.61 14.4 25.95
68 INT22066 Gene_expression of Phax 40 0.78 22.51 25.91
69 INT95788 Positive_regulation of Positive_regulation of Mapk1 83 0.69 24.75 25.84
70 INT5426 Negative_regulation of RTCA 58 0.51 12.34 25.74
71 INT11014 Phosphorylation of CREB1 72 0.81 26.35 25.64
72 INT12124 Gene_expression of MAPK1 141 0.75 82.4 25.58
73 INT96904 Regulation of Prkaca 33 0.44 10.86 24.51
74 INT40776 Gene_expression of Akt1 99 0.77 34.91 24.39
75 INT27933 Gene_expression of NCOR2 65 0.72 31.35 24.23
76 INT117718 Positive_regulation of Phosphorylation of Akt1 112 0.69 39.26 24.09
77 INT71781 Phosphorylation of MAPK3 62 0.80 27.73 23.73
78 INT86534 Positive_regulation of MAPK14 81 0.62 57.81 23.62
79 INT35716 Positive_regulation of NCOR2 45 0.60 18 23.54
80 INT18884 Regulation of RYBP 25 0.38 11.43 23.2
81 INT61160 Negative_regulation of Gene_expression of Creb1 37 0.59 17.95 23.17
82 INT55170 Gene_expression of NFKB1 97 0.77 52.75 23.04
83 INT69322 Negative_regulation of MAPK14 70 0.54 42.92 22.71
84 INT66208 Positive_regulation of Positive_regulation of NFKB1 45 0.68 20.17 22.62
85 INT823 Negative_regulation of ESR1 144 0.58 63.72 22.52
86 INT106175 Positive_regulation of Positive_regulation of Creb1 37 0.70 13.89 22.46
87 INT171924 Gene_expression of MAPK14 60 0.65 54.38 21.68
88 INT73625 Gene_expression of PPARG 108 0.78 104.85 21.42
89 INT101517 Negative_regulation of PPARA 168 0.57 112.24 21.41
90 INT89805 Gene_expression of Prkaca 45 0.77 11.03 20.77
91 INT85952 Positive_regulation of AR 168 0.67 64.36 20.66
92 INT61159 Regulation of Gene_expression of Creb1 46 0.62 24.07 20.52
93 INT79805 Phosphorylation of PRKCA 57 0.81 23.33 20.41
94 INT89396 Phosphorylation of AKT1 225 0.82 111.66 19.61
95 INT86187 Positive_regulation of AKT1 199 0.69 122.13 19.44
96 INT184895 Gene_expression of MCRS1 46 0.42 56.03 19.44
97 INT91462 Positive_regulation of Phosphorylation of MAPK1 99 0.67 40.28 18.99
98 INT69592 Positive_regulation of PSMD1 27 0.70 17.83 18.98
99 INT56749 Gene_expression of PCNA 219 0.77 111.25 18.42
100 INT28215 Gene_expression of CDKN1A 196 0.76 113.9 18.3
101 INT61158 Negative_regulation of Creb1 33 0.59 11.54 18.06
102 INT21072 Localization of Adarb1 26 0.69 2.76 17.95
103 INT151747 Positive_regulation of PSMD2 26 0.68 17.48 17.89
104 INT71787 Positive_regulation of MAPK3 37 0.67 17.5 17.88
105 INT116950 Negative_regulation of MAPK8 103 0.57 44.48 17.53
106 INT94467 Positive_regulation of Hand1 71 0.58 59 16.96
107 INT65856 Positive_regulation of TP53 138 0.67 112.65 16.71
108 INT93361 Gene_expression of Trp53 208 0.78 175.35 16.65
109 INT109929 Phosphorylation of MAPK8 102 0.81 39.98 16.54
110 INT95790 Regulation of Mapk1 55 0.61 21.17 16.31
111 INT104045 Regulation of Hand1 65 0.35 51.32 16.26
112 INT108588 Gene_expression of CASP3 126 0.78 84.49 16.2
113 INT25517 Regulation of NFKB1 41 0.61 22.28 16.09
114 INT80972 Gene_expression of Tp53 104 0.78 102.74 16.02
115 INT65659 Positive_regulation of STAT3 132 0.70 69.56 15.95
116 INT97245 Gene_expression of AKT1 217 0.77 119.63 15.59
117 INT111462 Negative_regulation of Phosphorylation of Mapk1 45 0.57 19.49 15.59
118 INT92354 Localization of ESR1 77 0.75 33.04 15.51
119 INT54572 Negative_regulation of Positive_regulation of NFKB1 46 0.58 21.45 15.47
120 INT61172 Gene_expression of PRKCA 34 0.77 8.89 15.47
121 INT75531 Regulation of MAPK1 70 0.61 34.39 15.42
122 INT128401 Positive_regulation of Positive_regulation of Mapk1 39 0.70 10.88 15.38
123 INT75540 Positive_regulation of TH1L 62 0.67 43.45 15.02
124 INT75502 Positive_regulation of CDKN1A 123 0.68 70.75 14.74
125 INT60197 Gene_expression of JUN 90 0.78 42.32 14.61
126 INT103096 Regulation of PPARA 113 0.60 62.47 14.57
127 INT40478 Negative_regulation of NCOR2 23 0.48 12.77 14.56
128 INT100139 Positive_regulation of Gene_expression of PPARA 160 0.63 97.78 14.53
129 INT20420 Gene_expression of MYC 99 0.75 49.32 14.36
130 INT80688 Positive_regulation of Positive_regulation of MAPK1 72 0.69 39.35 14.11
131 INT39733 Localization of NFKB1 59 0.79 22.76 13.99
132 INT94774 Regulation of CDKN2A 43 0.60 44.41 13.99
133 INT184890 Regulation of MCRS1 35 0.22 44.35 13.78
134 INT111529 Phosphorylation of Mapk3 41 0.80 21.14 13.72
135 INT52714 Regulation of PRKCA 28 0.61 7.73 13.66
136 INT78472 Gene_expression of CDKN2A 223 0.78 173.76 13.61
137 INT67855 Negative_regulation of PPIG 64 0.57 17.83 13.54
138 INT18882 Negative_regulation of Localization of RYBP 11 0.49 1.15 13.51
139 INT60764 Positive_regulation of PPIG 39 0.67 17.08 13.48
140 INT80685 Gene_expression of MAPK8 90 0.72 51.91 13.36
141 INT20378 Localization of Hand1 53 0.71 41.96 13.31
142 INT18616 Positive_regulation of Positive_regulation of Adarb1 18 0.33 2.04 13.18
143 INT55168 Binding of NFKB1 55 0.48 22.94 13.15
144 INT16713 Binding of Creb1 53 0.48 20.24 13.06
145 INT15246 Regulation of FOS 32 0.60 15.34 12.94
146 INT48927 Regulation of Mapk3 25 0.60 14.06 12.82
147 INT27242 Gene_expression of PGR 153 0.75 98.77 12.79
148 INT89395 Negative_regulation of AKT1 127 0.58 70.27 12.54
149 INT122812 Gene_expression of SNRNP70 130 0.75 67 12.5
150 INT94464 Negative_regulation of Hand1 44 0.41 31.5 12.39
151 INT150676 Positive_regulation of Gene_expression of Mapk1 30 0.45 10.06 12.37
152 INT50580 Binding of PPIG 39 0.36 11.17 12.34
153 INT119396 Regulation of Positive_regulation of Mapk1 22 0.61 7.88 12.25
154 INT13409 Gene_expression of NEUROD1 52 0.75 14.17 12.23
155 INT79545 Positive_regulation of Gene_expression of ESR1 82 0.64 39.42 12.18
156 INT26534 Regulation of Akt1 34 0.61 14.47 11.86
157 INT114674 Gene_expression of Mdm2 15 0.78 3.51 11.85
158 INT111476 Gene_expression of TP63 88 0.76 61.08 11.64
159 INT102272 Regulation of TH1L 41 0.44 30.89 11.63
160 INT119700 Gene_expression of VDR 88 0.75 65.33 11.5
161 INT78970 Positive_regulation of Positive_regulation of Prkaca 14 0.47 3.06 11.49
162 INT72221 Localization of PRKCA 17 0.81 1.23 11.47
163 INT52775 Positive_regulation of Phax 15 0.42 6.87 11.45
164 INT75525 Negative_regulation of Positive_regulation of MAPK1 40 0.59 25.15 11.15
165 INT70877 Gene_expression of PPIG 72 0.75 22.39 10.93
166 INT94465 Positive_regulation of Gene_expression of Hand1 43 0.38 29.76 10.88
167 INT79656 Positive_regulation of NR3C1 14 0.68 6.38 10.83
168 INT15804 Gene_expression of ISG20 83 0.75 44.33 10.58
169 INT58904 Localization of TH1L 40 0.68 27.11 10.52
170 INT113765 Phosphorylation of Adarb1 10 0.05 4.91 10.51
171 INT39699 Negative_regulation of Positive_regulation of RYBP 11 0.41 3.73 10.42
172 INT48921 Regulation of Mapk1 25 0.49 19.51 10.41
173 INT87451 Positive_regulation of Mapk3 34 0.67 12.82 10.38
174 INT110178 Phosphorylation of MAPK14 40 0.68 19.38 10.37
175 INT72924 Negative_regulation of MCRS1 27 0.19 33.59 10.29
176 INT60198 Binding of JUN 54 0.48 11.56 10.27
177 INT173159 Localization of PPARA 96 0.74 64.55 10.26
178 INT49660 Positive_regulation of EGR1 54 0.69 32.17 9.89
179 INT169997 Positive_regulation of Gene_expression of Tp53 37 0.70 47.3 9.85
180 INT122584 Negative_regulation of Gene_expression of PPARA 56 0.58 37.61 9.76
181 INT69306 Negative_regulation of TH1L 28 0.57 24.81 9.74
182 INT57162 Positive_regulation of Gene_expression of CDKN1A 64 0.68 35.3 9.69
183 INT123701 Negative_regulation of VDR 61 0.59 48.94 9.67
184 INT73021 Gene_expression of EGR1 43 0.77 24.65 9.18
185 INT54588 Positive_regulation of CREB1 38 0.67 12.01 9.18
186 INT94196 Negative_regulation of Phosphorylation of MAPK1 60 0.59 31.64 9.16
187 INT48978 Negative_regulation of FOS 41 0.57 11.94 9.14
188 INT152668 Negative_regulation of EP300 13 0.38 7.78 9.03
189 INT128159 Positive_regulation of DDIT3 29 0.67 29.5 8.99
190 INT158796 Positive_regulation of SMUG1 67 0.70 38.97 8.98
191 INT120967 Negative_regulation of Phosphorylation of Akt1 47 0.57 23.67 8.98
192 INT109432 Negative_regulation of Phosphorylation of Mapk1 19 0.54 7.01 8.98
193 INT67612 Binding of PPARG 38 0.48 22.67 8.94
194 INT35366 Binding of AR 87 0.47 30.52 8.9
195 INT111133 Negative_regulation of Mapk3 31 0.57 10.89 8.9
196 INT6019 Positive_regulation of NEUROD1 37 0.67 17.3 8.89
197 INT49866 Negative_regulation of Parp1 53 0.58 35.37 8.84
198 INT66213 Localization of RELA 63 0.78 14.71 8.77
199 INT113845 Protein_catabolism of PARP1 54 0.88 43.86 8.77
200 INT175554 Binding of MCRS1 21 0.23 25.2 8.59
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