GO:0005720

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Name nuclear heterochromatin
Categary Component
Go Slim No
Go Link GO:0005720
Unique Molecular Interactions 128
Total Molecular Interactions 170
Total Single Events 975
Pain Genes Associated 19

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for nuclear heterochromatin. They are ordered first by their pain relevance and then by number of times they were reported for nuclear heterochromatin. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT73116 TYMS Negative_regulation of DNMT3B 1 0.24 0 1.6
2 INT73115 TYMS Negative_regulation of Positive_regulation of DNMT3B 1 0.24 0 1.6
3 INT340300 Ea1 Positive_regulation of Gene_expression of Sirt1 1 0.08 1.68 1.49
4 INT160540 Binding of NGF and PSIP1 2 0.29 1.43 1.12
5 INT160541 Binding of BDNF and PSIP1 4 0.49 1.94 1.02
6 INT340294 Ea1 Positive_regulation of Sirt1 1 0.06 0.53 0.83
7 INT214595 Binding of FOXC1 and TIMP1 1 0.02 0.96 0.66
8 INT65185 Binding of ATRX and Ssr1 1 0.03 1.68 0.49
9 INT340296 Ea1 Regulation of Gene_expression of Sirt1 1 0.08 0.15 0.46
10 INT285718 Binding of DNMT3B and Lbp 1 0.08 0.33 0.33
11 INT128756 Binding of Esr1 and Foxc1 1 0.01 0.43 0.32
12 INT335027 Binding of Vdr and Fgf23 1 0.24 0.34 0.29
13 INT214615 FOXC1 Positive_regulation of Gene_expression of Ang 1 0.01 0.29 0.28
14 INT214594 Binding of FOXC1 and IBD9 1 0.00 1.81 0.28
15 INT228611 Binding of DNMT3B and LEP 1 0.04 0 0.25
16 INT262151 Vdr Regulation of Cyp24a1 1 0.24 0.24 0.23
17 INT214591 FOXC1 Regulation of ICAM1 1 0.05 0.29 0.19
18 INT335018 Vdr Positive_regulation of Gene_expression of Fgf23 1 0.44 0.36 0.17
19 INT190628 Negative_regulation of Binding of Rab7 and Sirt1 1 0.33 0.62 0.17
20 INT190638 Binding of Rab7 and Sirt1 1 0.29 0.62 0.17
21 INT289525 Sirt1 Negative_regulation of Negative_regulation of Ucp2 1 0.32 0.86 0.15
22 INT214593 Binding of FOXC1 and OAP 1 0.01 0.25 0.13
23 INT333765 Positive_regulation of Vdr Regulation of Gene_expression of Ccr6 1 0.21 0.48 0.12
24 INT270834 CBX1 Negative_regulation of Transcription of Panx1 1 0.06 0.13 0.1
25 INT270837 Negative_regulation of Panx1 Negative_regulation of Transcription of CBX1 1 0.07 0.13 0.1
26 INT166723 Binding of Vdr and Rxrb 1 0.11 0.31 0.09
27 INT166724 Binding of Vdr and Rxra 1 0.28 0.32 0.09
28 INT289539 Negative_regulation of Sirt1 Negative_regulation of Gene_expression of Agrp 1 0.29 0.47 0.09
29 INT246625 Sirt1 Positive_regulation of Negative_regulation of Trp53 1 0.10 0.96 0.08
30 INT289536 Sirt1 Negative_regulation of Localization of Pparg 1 0.13 0.43 0.08
31 INT262216 Positive_regulation of Nr1i2 Positive_regulation of Gene_expression of Vdr 1 0.29 0.44 0.08
32 INT289603 Sirt1 Negative_regulation of Localization of PPARG 1 0.02 0.43 0.08
33 INT289540 Sirt1 Negative_regulation of Localization of Ins1 1 0.03 0.43 0.08
34 INT289533 Sirt1 Negative_regulation of Pparg 1 0.18 0.42 0.07
35 INT256160 Positive_regulation of Binding of Pgc and Sirt1 1 0.55 0.21 0.07
36 INT289602 Sirt1 Negative_regulation of PPARG 1 0.02 0.37 0.07
37 INT256161 Binding of Pgc and Sirt1 1 0.38 0.21 0.07
38 INT228610 Binding of DNMT3B and ASPRV1 1 0.02 0 0.05
39 INT340293 Binding of Ins1 and Sirt1 1 0.25 1.25 0.05
40 INT262196 Nr1i2 Negative_regulation of Vdr 1 0.27 0.14 0.04
41 INT262166 Binding of Nr1i2 and Vdr 1 0.23 0.14 0.04
42 INT289541 Sirt1 Regulation of Gene_expression of Agrp 1 0.41 0.52 0.04
43 INT262154 Vdr Negative_regulation of Cyp24a1 1 0.16 0.14 0.04
44 INT289538 Sirt1 Positive_regulation of Stat3 1 0.34 0.37 0.04
45 INT332938 Suv39h1 Positive_regulation of Hist1h3f 1 0.06 0.12 0.03
46 INT289542 Sirt1 Negative_regulation of Stat3 1 0.32 0.31 0.03
47 INT289526 Binding of Arc and Sirt1 1 0.08 0.55 0.03
48 INT289599 Sirt1 Positive_regulation of Ppargc1a 1 0.51 0.36 0.03
49 INT180040 Binding of D7Cwr3P and Sirt1 1 0.00 0 0
50 INT241268 DNMT3B Positive_regulation of Gene_expression of DNMT1 1 0.19 0.67 0
51 INT300696 Sirt1 Regulation of Cyb5r3 1 0.03 0 0
52 INT192046 Negative_regulation of Binding of RYR2 and Cbx5 1 0.01 1.12 0
53 INT183412 Dnmt3a Positive_regulation of Tbx15 1 0.05 0.27 0
54 INT299444 Foxl2 Positive_regulation of Sirt1 1 0.24 0.31 0
55 INT289600 Negative_regulation of Binding of Sirt1 and Sirt1 1 0.47 1.17 0
56 INT299458 Gene_expression of Sirt1 Negative_regulation of Foxl2 1 0.25 0.32 0
57 INT342385 Positive_regulation of Binding of Lrp5 and Vdr 1 0.53 0.98 0
58 INT204325 Binding of PPARGC1A and SIRT1 1 0.39 0.19 0
59 INT342378 Binding of Vdr and Best1 1 0.05 0.4 0
60 INT289534 Sirt1 Regulation of Regulation of Pomc 1 0.04 0.15 0
61 INT241266 DNMT3B Positive_regulation of Gene_expression of GOPC 1 0.05 0.68 0
62 INT256165 Binding of Sirt6 and Sirt1 1 0.13 0.58 0
63 INT318218 SIRT1 Positive_regulation of Binding of FOXO3 1 0.44 0.51 0
64 INT289518 Arc Regulation of Sirt1 1 0.10 0.56 0
65 INT183413 Dnmt3a Positive_regulation of Gene_expression of Dnmt3b 1 0.10 0.28 0
66 INT241264 DNMT1 Positive_regulation of Gene_expression of DNMT3B 1 0.19 0.67 0
67 INT241257 DNMT3B Positive_regulation of OPCML 1 0.35 0.68 0
68 INT289537 Lep Negative_regulation of Sirt1 1 0.20 0.05 0
69 INT318219 SIRT1 Regulation of TBK1 1 0.03 0.43 0
70 INT318132 Binding of ATRX and HBE1 1 0.00 1.47 0
71 INT152543 CBX1 Regulation of Gene_expression of RETNLB 1 0.00 0 0
72 INT342381 Binding of Lrp5 and Vdr 1 0.55 0.97 0
73 INT241259 DNMT3B Positive_regulation of GOPC 1 0.05 0.68 0
74 INT183415 Dnmt3b Positive_regulation of Gene_expression of Dnmt3a 1 0.10 0.28 0
75 INT289517 Sirt1 Regulation of Prkag1 1 0.02 0.08 0
76 INT88567 COL2A1 Positive_regulation of A1cf 1 0.09 0.36 0
77 INT204326 SIRT1 Positive_regulation of PPARGC1A 1 0.51 0.19 0
78 INT318221 SIRT1 Positive_regulation of FOXO3 1 0.41 0.63 0
79 INT342388 Binding of CALCR and Vdr 1 0.12 0.83 0
80 INT337637 SIRT1 Negative_regulation of TP53 1 0.23 1.49 0
81 INT289598 Binding of Sirt1 and Sirt1 1 0.41 1.15 0
82 INT152541 CBX1 Negative_regulation of Gene_expression of PTGES 1 0.15 0.3 0
83 INT225578 Binding of Vdr and Pprc1 1 0.00 0 0
84 INT253331 Binding of DNMT3B and SP140 1 0.04 0.17 0
85 INT300307 Binding of Tp53 and Sirt1 1 0.24 0.98 0
86 INT289519 Sirt1 Regulation of Rps6kb1 1 0.25 0.13 0
87 INT289530 Sirt1 Regulation of Foxo1 1 0.25 0.42 0
88 INT289523 Binding of Foxo1 and Positive_regulation of Sirt1 1 0.36 0.13 0
89 INT192043 Binding of RYR2 and Cbx5 1 0.01 1.12 0
90 INT204321 NOS3 Regulation of SIRT1 1 0.23 0.1 0
91 INT314132 Sirt1 Positive_regulation of Ppargc1a 1 0.50 2.3 0
92 INT183410 Dnmt3b Positive_regulation of Tbx15 1 0.05 0.27 0
93 INT299451 Foxl2 Negative_regulation of Gene_expression of Sirt1 1 0.25 0.32 0
94 INT289531 Acsm3 Positive_regulation of Sirt1 1 0.01 0.27 0
95 INT326729 Foxc1 Positive_regulation of Gene_expression of Ehf 1 0.23 0.26 0
96 INT320526 Binding of TRIM28 and KRBA1 1 0.02 0.13 0
97 INT297846 Nanos2 Regulation of Dnmt3l 1 0.34 0.6 0
98 INT191135 Binding of DNMT3A and DNMT3B 1 0.09 0 0
99 INT318216 SIRT1 Positive_regulation of Gene_expression of FOXO3 1 0.36 0.52 0
100 INT318217 SIRT1 Regulation of TP53 1 0.07 0.43 0
101 INT204319 SIRT1 Regulation of Gene_expression of PPARGC1A 1 0.50 0.12 0
102 INT320527 Binding of TRIM28 and AHRR 1 0.01 0.07 0
103 INT289535 Negative_regulation of Sirt1 Negative_regulation of Binding of Foxo1 1 0.29 0.14 0
104 INT270836 CBX1 Negative_regulation of Panx1 1 0.09 0 0
105 INT289529 Lep Regulation of Sirt1 1 0.28 0.19 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for nuclear heterochromatin. They are ordered first by their pain relevance and then by number of times they were reported in nuclear heterochromatin. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT115370 Gene_expression of PSIP1 22 0.65 9.45 5.68
2 INT4613 Positive_regulation of Sirt1 32 0.67 18.19 5.53
3 INT73117 Positive_regulation of DNMT3B 20 0.47 10.31 5.31
4 INT240934 Gene_expression of Sirt1 24 0.75 18.77 4.68
5 INT136106 Gene_expression of DNMT3B 30 0.58 8.43 3.7
6 INT121531 Negative_regulation of DNMT3B 13 0.36 3.46 3.05
7 INT50559 Binding of A1cf 4 0.34 0.8 2.97
8 INT133038 Binding of DNMT3B 26 0.40 5.97 2.83
9 INT160633 Gene_expression of Vdr 21 0.77 10.01 2.73
10 INT221409 Regulation of Sirt1 8 0.58 5.53 2.1
11 INT19609 Positive_regulation of PSIP1 4 0.49 4.54 2.04
12 INT115369 Positive_regulation of Gene_expression of PSIP1 4 0.49 4.92 1.88
13 INT99964 Gene_expression of A1cf 7 0.66 12.71 1.87
14 INT255787 Positive_regulation of Gene_expression of Sirt1 9 0.67 7.61 1.5
15 INT289575 Gene_expression of Sirt1 47 0.77 29.29 1.47
16 INT157500 Localization of DNMT3B 12 0.73 2.21 1.38
17 INT61756 Positive_regulation of A1cf 8 0.57 4.94 1.29
18 INT46336 Regulation of DNMT3B 12 0.53 4.91 1.25
19 INT958 Negative_regulation of ATRX 6 0.58 2.92 1.25
20 INT39711 Negative_regulation of FOXC1 4 0.41 4.29 1.2
21 INT81311 Gene_expression of FOXC1 9 0.44 3.46 1.18
22 INT322088 Regulation of Regulation of DNMT3B 1 0.03 2.74 1.12
23 INT112214 Gene_expression of Vdr 4 0.33 3.59 1.11
24 INT156427 Localization of FOXC1 2 0.73 1.36 1.07
25 INT101569 Positive_regulation of Gene_expression of A1cf 4 0.49 6.35 1.05
26 INT289553 Positive_regulation of Gene_expression of Sirt1 21 0.69 20.43 1.03
27 INT168065 Binding of Sirt1 13 0.47 4.55 1.02
28 INT214609 Positive_regulation of Gene_expression of FOXC1 1 0.08 1.78 1
29 INT46334 Binding of FOXC1 2 0.36 2.66 0.99
30 INT43131 Regulation of FOXC1 3 0.36 1.09 0.98
31 INT285716 Negative_regulation of Gene_expression of DNMT3B 1 0.21 0.96 0.96
32 INT959 Regulation of ATRX 5 0.47 5.04 0.89
33 INT61755 Negative_regulation of A1cf 8 0.58 6.32 0.87
34 INT289550 Positive_regulation of Sirt1 25 0.69 13.59 0.8
35 INT262107 Binding of Vdr 9 0.48 6.56 0.71
36 INT169421 Positive_regulation of FOXC1 4 0.49 2.42 0.7
37 INT262060 Positive_regulation of Vdr 8 0.58 2.84 0.67
38 INT61757 Negative_regulation of Positive_regulation of A1cf 1 0.48 2.29 0.62
39 INT183979 Localization of PSIP1 2 0.73 1.37 0.59
40 INT124270 Positive_regulation of Gene_expression of Vdr 2 0.29 1.1 0.58
41 INT241287 Positive_regulation of Gene_expression of DNMT3B 3 0.40 1.21 0.57
42 INT289580 Negative_regulation of Sirt1 23 0.58 9.03 0.48
43 INT300291 Phosphorylation of Sirt1 1 0.77 6.07 0.45
44 INT112215 Binding of Vdr 4 0.31 2.43 0.44
45 INT160642 Positive_regulation of Gene_expression of Vdr 5 0.62 1.61 0.42
46 INT240935 Transcription of Sirt1 2 0.68 0.42 0.42
47 INT340290 Regulation of Transcription of Sirt1 1 0.43 0.13 0.42
48 INT306690 Negative_regulation of Dnmt3b 1 0.00 0.56 0.39
49 INT166420 Negative_regulation of PSIP1 2 0.42 1 0.38
50 INT961 Positive_regulation of ATRX 3 0.53 1.99 0.36
51 INT240914 Negative_regulation of Sirt1 9 0.46 3.16 0.34
52 INT262063 Localization of Vdr 3 0.75 1.76 0.33
53 INT128754 Binding of Foxc1 1 0.01 0.43 0.32
54 INT289546 Negative_regulation of Gene_expression of Sirt1 5 0.42 3.1 0.31
55 INT204368 Gene_expression of SIRT1 17 0.76 4.48 0.3
56 INT78401 Regulation of A1cf 1 0.24 0.83 0.29
57 INT345260 Transcription of ATRX 1 0.31 0.28 0.28
58 INT962 Gene_expression of ATRX 2 0.59 1.72 0.27
59 INT214611 Positive_regulation of Localization of FOXC1 1 0.07 0.34 0.26
60 INT102637 Positive_regulation of Vdr 3 0.48 2.82 0.24
61 INT300944 Regulation of DNMT3A 1 0.21 0.91 0.24
62 INT61754 Positive_regulation of Binding of A1cf 1 0.44 0.8 0.21
63 INT262040 Negative_regulation of Gene_expression of Vdr 1 0.25 0.26 0.21
64 INT289551 Regulation of Sirt1 8 0.61 4.46 0.2
65 INT270814 Negative_regulation of Transcription of CBX1 1 0.07 0.27 0.2
66 INT246620 Negative_regulation of Positive_regulation of Sirt1 2 0.39 1.9 0.17
67 INT160641 Transcription of Vdr 5 0.71 3.1 0.16
68 INT185203 Regulation of Regulation of FOXC1 1 0.16 0 0.15
69 INT960 Negative_regulation of Positive_regulation of ATRX 1 0.45 0 0.15
70 INT256111 Regulation of Gene_expression of Sirt1 1 0.32 0.73 0.14
71 INT291670 Negative_regulation of Dnmt3a 1 0.31 0.7 0.14
72 INT204365 Positive_regulation of Gene_expression of SIRT1 8 0.68 2.9 0.13
73 INT191163 Transcription of DNMT3B 4 0.50 0.46 0.13
74 INT333738 Regulation of Positive_regulation of Vdr 1 0.38 0.48 0.12
75 INT99963 Negative_regulation of Gene_expression of A1cf 1 0.19 1.09 0.12
76 INT289543 Regulation of Gene_expression of Sirt1 3 0.45 1.81 0.11
77 INT289547 Positive_regulation of Positive_regulation of Sirt1 2 0.69 0.76 0.11
78 INT332681 Regulation of Positive_regulation of Sirt1 1 0.16 0.69 0.11
79 INT116545 Negative_regulation of Negative_regulation of A1cf 2 0.31 1.45 0.1
80 INT270820 Transcription of CBX1 1 0.11 0.13 0.1
81 INT143835 Gene_expression of Foxc1 2 0.39 1.17 0.09
82 INT74442 Binding of ATRX 2 0.41 3.2 0.09
83 INT143833 Positive_regulation of Foxc1 2 0.42 1.02 0.09
84 INT289567 Regulation of Negative_regulation of Sirt1 1 0.45 0.74 0.09
85 INT143836 Negative_regulation of Foxc1 1 0.35 0.92 0.09
86 INT347970 Localization of CBX1 2 0.05 1.23 0.08
87 INT347969 Negative_regulation of CBX1 1 0.03 1.08 0.08
88 INT289574 Negative_regulation of Positive_regulation of Sirt1 1 0.42 0.42 0.07
89 INT256136 Negative_regulation of Binding of Sirt1 1 0.30 0.5 0.07
90 INT292609 Negative_regulation of Positive_regulation of DNMT3B 1 0.22 1.3 0.07
91 INT211082 Regulation of Positive_regulation of Vdr 1 0.30 1.18 0.07
92 INT339991 Localization of SIRT1 1 0.34 0.3 0.06
93 INT211079 Positive_regulation of Positive_regulation of Vdr 1 0.33 0.59 0.05
94 INT102100 Binding of PSIP1 1 0.24 0.34 0.05
95 INT256137 Positive_regulation of Regulation of Sirt1 1 0.36 0.32 0.05
96 INT318236 Negative_regulation of Gene_expression of SIRT1 1 0.42 0.59 0.05
97 INT289587 Negative_regulation of Negative_regulation of Sirt1 1 0.42 0.65 0.05
98 INT256129 Negative_regulation of Gene_expression of Sirt1 1 0.31 0.4 0.05
99 INT183393 Gene_expression of Dnmt3a 3 0.43 1.08 0.04
100 INT262079 Negative_regulation of Vdr 2 0.42 0.71 0.04
101 INT291678 Regulation of Dnmt3a 1 0.28 0.48 0.04
102 INT211080 Negative_regulation of Positive_regulation of Vdr 1 0.29 0.6 0.04
103 INT289584 Binding of Sirt1 3 0.48 1.35 0.03
104 INT270038 Positive_regulation of Positive_regulation of Sirt1 2 0.43 0.44 0.03
105 INT246622 Phosphorylation of Sirt1 2 0.74 0.56 0.03
106 INT185206 Transcription of FOXC1 1 0.31 0 0.03
107 INT332918 Localization of Suv39h1 1 0.73 0.11 0.03
108 INT185204 Positive_regulation of Transcription of FOXC1 1 0.27 0 0.03
109 INT185208 Positive_regulation of Positive_regulation of FOXC1 1 0.29 0 0.03
110 INT204367 Positive_regulation of SIRT1 13 0.68 4.17 0
111 INT204349 Regulation of SIRT1 8 0.61 1.99 0
112 INT256134 Localization of Sirt1 5 0.50 2.99 0
113 INT204353 Transcription of SIRT1 3 0.68 0.67 0
114 INT284943 Gene_expression of DNMT3A 2 0.39 1.46 0
115 INT270816 Binding of CBX1 2 0.06 0.17 0
116 INT284947 Positive_regulation of Gene_expression of DNMT3A 2 0.25 1.29 0
117 INT256827 Regulation of PSIP1 2 0.02 0.45 0
118 INT248544 Transcription of Foxc1 2 0.67 0.48 0
119 INT288196 Negative_regulation of Transcription of Vdr 1 0.23 0 0
120 INT191158 Transcription of DNMT3A 1 0.32 0.06 0
121 INT309867 Transcription of A1cf 1 0.14 0.57 0
122 INT191157 Negative_regulation of Transcription of DNMT3B 1 0.19 0.06 0
123 INT191156 Binding of DNMT3A 1 0.16 0 0
124 INT320553 Gene_expression of TRIM28 1 0.48 0.06 0
125 INT204361 Negative_regulation of SIRT1 1 0.42 0.18 0
126 INT289569 Transcription of Sirt1 1 0.71 0.25 0
127 INT300686 Regulation of Binding of Sirt1 1 0.44 0.06 0
128 INT270818 Negative_regulation of Gene_expression of CBX1 1 0.07 0 0
129 INT256828 Phosphorylation of PSIP1 1 0.00 0.2 0
130 INT301205 Negative_regulation of Gene_expression of Dnmt3l 1 0.20 0.81 0
131 INT300287 Localization of Sirt1 1 0.66 1.46 0
132 INT140704 Transcription of Vdr 1 0.12 0.38 0
133 INT265972 Positive_regulation of Gene_expression of ATRX 1 0.38 1.72 0
134 INT289583 Regulation of Transcription of Sirt1 1 0.27 0.25 0
135 INT301226 Gene_expression of Dnmt3l 1 0.37 0.76 0
136 INT191160 Localization of DNMT3A 1 0.35 0 0
137 INT185991 Regulation of Gene_expression of DNMT3B 1 0.37 0 0
138 INT300683 Positive_regulation of Negative_regulation of Sirt1 1 0.45 0 0
139 INT204371 Positive_regulation of Transcription of SIRT1 1 0.49 0.13 0
140 INT272128 Positive_regulation of Localization of ATRX 1 0.14 0.46 0
141 INT191152 Negative_regulation of Transcription of DNMT3A 1 0.20 0.06 0
142 INT318239 Regulation of Transcription of SIRT1 1 0.26 0.45 0
143 INT328548 Negative_regulation of Gene_expression of Cbx5 1 0.05 0.08 0
144 INT328546 Gene_expression of Cbx5 1 0.07 0.08 0
145 INT240932 Negative_regulation of Transcription of Sirt1 1 0.34 0.29 0
146 INT289594 Regulation of Regulation of Sirt1 1 0.45 0.15 0
147 INT350520 Phosphorylation of SIRT1 1 0.25 0.72 0
148 INT204356 Regulation of Gene_expression of SIRT1 1 0.61 0.29 0
149 INT183396 Positive_regulation of Gene_expression of Dnmt3a 1 0.20 0.59 0
150 INT342376 Positive_regulation of Binding of Vdr 1 0.46 0.86 0
151 INT270822 Gene_expression of CBX1 1 0.10 0 0
152 INT183391 Positive_regulation of Gene_expression of Dnmt3b 1 0.20 0.59 0
153 INT183398 Gene_expression of Dnmt3b 1 0.27 0.59 0
154 INT160644 Positive_regulation of Transcription of Vdr 1 0.62 0 0
155 INT338263 Regulation of Gene_expression of DNMT3A 1 0.31 0.18 0
156 INT272120 Localization of ATRX 1 0.27 1.36 0
157 INT309868 Localization of A1cf 1 0.15 1 0
158 INT297825 Regulation of Dnmt3l 1 0.39 0.59 0
159 INT204331 Binding of SIRT1 1 0.47 0.39 0
160 INT300685 Positive_regulation of Binding of Sirt1 1 0.67 0 0
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