GO:0005721

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Name centromeric heterochromatin
Categary Component
Go Slim No
Go Link GO:0005721
Unique Molecular Interactions 77
Total Molecular Interactions 81
Total Single Events 590
Pain Genes Associated 5

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for centromeric heterochromatin. They are ordered first by their pain relevance and then by number of times they were reported for centromeric heterochromatin. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT311766 INCENP Negative_regulation of Gene_expression of SLC1A3 1 0.04 0 0.55
2 INT101087 NTF3 Positive_regulation of Gene_expression of IKZF1 1 0.04 0.3 0.55
3 INT254768 DNMT1 Positive_regulation of Gene_expression of Apoe 1 0.02 0.05 0.49
4 INT108692 NTF3 Regulation of Gene_expression of IKZF1 1 0.69 0.7 0.49
5 INT150793 ZNF398 Negative_regulation of Gene_expression of DNMT1 1 0.07 0.46 0.48
6 INT231340 INCENP Regulation of Gene_expression of IL6 1 0.01 1.09 0.47
7 INT256321 INCENP Positive_regulation of Gene_expression of Vcam1 1 0.00 1.89 0.38
8 INT299788 INCENP Negative_regulation of Gene_expression of NPEPPS 1 0.00 0.86 0.37
9 INT226375 INCENP Positive_regulation of Regulation of TH1L 1 0.01 0.57 0.29
10 INT226376 INCENP Negative_regulation of Gene_expression of TH1L 1 0.00 0.61 0.29
11 INT226383 IL22 Positive_regulation of Gene_expression of INCENP 1 0.00 0.85 0.28
12 INT306267 Binding of INCENP and TP53 1 0.02 0.83 0.27
13 INT302468 INCENP Positive_regulation of Gene_expression of MMP9 1 0.01 0.72 0.26
14 INT254772 DNMT1 Positive_regulation of Apoe 1 0.02 0 0.25
15 INT252213 INCENP Regulation of Lgals3 1 0.00 1.91 0.23
16 INT183945 INCENP Positive_regulation of Localization of IL6 1 0.00 0.2 0.23
17 INT254774 DNMT1 Positive_regulation of Localization of Apoe 1 0.01 0.31 0.23
18 INT254770 Regulation of Binding of DNMT1 and Igh-Dex 1 0.00 0 0.22
19 INT226384 INCENP Positive_regulation of IL19 1 0.00 0.58 0.2
20 INT265048 INCENP Positive_regulation of Positive_regulation of Nfasc 1 0.00 0.69 0.19
21 INT254771 Binding of DNMT1 and Igh-Dex 1 0.00 0 0.19
22 INT226372 INCENP Negative_regulation of Gene_expression of IL5 1 0.00 1.12 0.18
23 INT231866 INCENP Regulation of Positive_regulation of Racgap1 1 0.00 0.58 0.18
24 INT222443 INCENP Positive_regulation of Localization of Pomc 1 0.00 0.75 0.17
25 INT226367 INCENP Negative_regulation of SOCS1 1 0.01 0.47 0.15
26 INT343833 INCENP Positive_regulation of TLR4 1 0.01 0.92 0.14
27 INT343840 Protein_catabolism of INCENP Positive_regulation of TLR4 1 0.01 0.92 0.14
28 INT226378 INCENP Positive_regulation of Transcription of SOCS1 1 0.01 0.41 0.13
29 INT210161 INCENP Positive_regulation of TNFRSF8 1 0.02 0.93 0.12
30 INT235385 INCENP Negative_regulation of Bche 1 0.01 0.19 0.11
31 INT270834 CBX1 Negative_regulation of Transcription of Panx1 1 0.06 0.13 0.1
32 INT270837 Negative_regulation of Panx1 Negative_regulation of Transcription of CBX1 1 0.07 0.13 0.1
33 INT222442 Tlr4 Positive_regulation of Gene_expression of INCENP 1 0.00 0.34 0.09
34 INT173058 INCENP Positive_regulation of Gene_expression of VEGFA 1 0.03 1.48 0.08
35 INT222662 Il1a Positive_regulation of Gene_expression of INCENP 1 0.00 0.32 0.08
36 INT257777 INCENP Positive_regulation of AR 1 0.04 0.49 0.08
37 INT186712 INCENP Positive_regulation of PPARA 1 0.01 1.05 0.08
38 INT294220 INCENP Positive_regulation of Gene_expression of Serpine1 1 0.00 0.41 0.08
39 INT294218 INCENP Positive_regulation of Plat 1 0.00 0.4 0.08
40 INT335711 INCENP Positive_regulation of Gene_expression of FAS 1 0.04 1.42 0.06
41 INT306510 INCENP Regulation of Gene_expression of Clu 1 0.00 1.92 0.05
42 INT327822 INCENP Regulation of Gene_expression of Lep 1 0.00 0.5 0.05
43 INT173612 FGFR1 Positive_regulation of INCENP 1 0.00 0.28 0.03
44 INT173613 BMP2 Positive_regulation of INCENP 1 0.00 0.28 0.03
45 INT318191 INCENP Negative_regulation of Gene_expression of VEGFA 1 0.00 1.05 0.03
46 INT300179 Binding of BGLAP and INCENP 1 0.02 0.08 0.03
47 INT183757 INCENP Negative_regulation of Transcription of CXCR4 1 0.01 0.93 0.03
48 INT318187 Binding of INCENP and MUC5AC 1 0.00 1.03 0.03
49 INT183758 INCENP Negative_regulation of Transcription of CCR5 1 0.00 0.93 0.03
50 INT231862 F2 Positive_regulation of INCENP 1 0.00 0.86 0.03
51 INT241268 DNMT3B Positive_regulation of Gene_expression of DNMT1 1 0.19 0.67 0
52 INT279515 Daf2 Negative_regulation of INCENP 1 0.00 0 0
53 INT343999 INCENP Positive_regulation of BMP2 1 0.01 0 0
54 INT330697 PCNA Regulation of INCENP 1 0.00 0.3 0
55 INT171600 INCENP Negative_regulation of Lipg 1 0.00 0.38 0
56 INT284918 RUNX1T1 Regulation of DNMT1 1 0.21 1.09 0
57 INT192049 Negative_regulation of Binding of RYR2 and Cbx1 1 0.01 1.12 0
58 INT329101 Binding of CD4 and INCENP 1 0.01 0.11 0
59 INT241264 DNMT1 Positive_regulation of Gene_expression of DNMT3B 1 0.19 0.67 0
60 INT152543 CBX1 Regulation of Gene_expression of RETNLB 1 0.00 0 0
61 INT222665 INCENP Positive_regulation of Localization of Gnrh1 1 0.00 0.09 0
62 INT171601 INCENP Negative_regulation of Lpl 1 0.01 0.38 0
63 INT344001 INCENP Positive_regulation of Gene_expression of BMP2 1 0.01 0 0
64 INT297124 Binding of INCENP and Hephl1 1 0.00 0.17 0
65 INT313653 INCENP Negative_regulation of PLA2G2D 1 0.01 0 0
66 INT152541 CBX1 Negative_regulation of Gene_expression of PTGES 1 0.15 0.3 0
67 INT220455 BAG6 Regulation of INCENP 1 0.00 0.32 0
68 INT209631 INCENP Negative_regulation of CHRM1 1 0.00 0.43 0
69 INT224993 INCENP Regulation of PDGFB 1 0.00 0 0
70 INT192047 Binding of RYR2 and Cbx1 1 0.01 1.12 0
71 INT241265 DNMT1 Positive_regulation of OPCML 1 0.31 0.68 0
72 INT255203 Binding of INCENP and Ie 1 0.00 0.77 0
73 INT241269 DNMT1 Positive_regulation of Gene_expression of GOPC 1 0.04 0.68 0
74 INT279514 Cr1l Negative_regulation of INCENP 1 0.00 0 0
75 INT241254 DNMT1 Positive_regulation of GOPC 1 0.04 0.68 0
76 INT209640 INCENP Negative_regulation of Gene_expression of CHRM1 1 0.00 0.91 0
77 INT270836 CBX1 Negative_regulation of Panx1 1 0.09 0 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for centromeric heterochromatin. They are ordered first by their pain relevance and then by number of times they were reported in centromeric heterochromatin. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT170335 Gene_expression of INCENP 176 0.54 91.62 15.31
2 INT174838 Localization of INCENP 80 0.64 19.05 12.89
3 INT173639 Positive_regulation of INCENP 40 0.14 20.97 6.7
4 INT8101 Binding of INCENP 42 0.31 16.2 6.68
5 INT103350 Gene_expression of DNMT1 15 0.67 9.77 3.83
6 INT172551 Negative_regulation of INCENP 38 0.07 20.83 3.14
7 INT172177 Protein_catabolism of INCENP 18 0.37 6.34 2.91
8 INT222400 Negative_regulation of Localization of INCENP 4 0.02 1.82 2.46
9 INT173090 Regulation of INCENP 24 0.09 9.45 2.16
10 INT17688 Positive_regulation of IKZF1 5 0.50 0.48 2.11
11 INT181280 Regulation of Gene_expression of INCENP 5 0.07 4 1.78
12 INT101090 Gene_expression of IKZF1 6 0.77 2.98 1.58
13 INT171975 Negative_regulation of Gene_expression of INCENP 8 0.05 5.24 1.35
14 INT173877 Positive_regulation of Gene_expression of INCENP 14 0.08 7.83 1.28
15 INT24266 Negative_regulation of IKZF1 6 0.37 1.55 0.96
16 INT101091 Regulation of IKZF1 3 0.09 0.3 0.79
17 INT201859 Positive_regulation of Gene_expression of DNMT1 4 0.60 6.43 0.75
18 INT181282 Transcription of INCENP 10 0.11 1.21 0.66
19 INT146400 Positive_regulation of DNMT1 4 0.45 0.91 0.43
20 INT353342 Positive_regulation of Positive_regulation of INCENP 1 0.01 0.46 0.4
21 INT222401 Regulation of Localization of INCENP 2 0.01 0.81 0.32
22 INT254763 Localization of DNMT1 1 0.05 0.2 0.29
23 INT184629 Negative_regulation of Positive_regulation of INCENP 1 0.05 0.89 0.28
24 INT226431 Phosphorylation of INCENP 3 0.04 3.41 0.26
25 INT284938 Regulation of DNMT1 2 0.22 1.17 0.24
26 INT118478 Transcription of IKZF1 1 0.48 0.52 0.23
27 INT291969 Negative_regulation of Gene_expression of IKZF1 1 0.13 1.15 0.22
28 INT270814 Negative_regulation of Transcription of CBX1 1 0.07 0.27 0.2
29 INT65782 Binding of Cbx1 1 0.05 0.14 0.14
30 INT291973 Binding of IKZF1 1 0.13 0.52 0.14
31 INT185754 Negative_regulation of Binding of INCENP 5 0.03 2.01 0.13
32 INT277821 Positive_regulation of Negative_regulation of INCENP 2 0.03 0.89 0.12
33 INT258077 Negative_regulation of Gene_expression of DNMT1 2 0.30 1.27 0.12
34 INT258063 Negative_regulation of DNMT1 3 0.28 1.36 0.11
35 INT270820 Transcription of CBX1 1 0.11 0.13 0.1
36 INT240093 Negative_regulation of Transcription of INCENP 1 0.01 0.26 0.09
37 INT254762 Positive_regulation of Positive_regulation of DNMT1 1 0.04 0 0.09
38 INT347970 Localization of CBX1 2 0.05 1.23 0.08
39 INT347969 Negative_regulation of CBX1 1 0.03 1.08 0.08
40 INT284977 Binding of DNMT1 3 0.17 0.86 0
41 INT270816 Binding of CBX1 2 0.06 0.17 0
42 INT284945 Protein_catabolism of DNMT1 2 0.32 0.47 0
43 INT181285 Positive_regulation of Transcription of INCENP 1 0.08 0 0
44 INT270818 Negative_regulation of Gene_expression of CBX1 1 0.07 0 0
45 INT284993 Positive_regulation of Protein_catabolism of DNMT1 1 0.22 0.26 0
46 INT328537 Gene_expression of Cbx1 1 0.02 0.08 0
47 INT270822 Gene_expression of CBX1 1 0.10 0 0
48 INT175536 Positive_regulation of Localization of INCENP 1 0.01 0.59 0
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