GO:0005757

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Name mitochondrial permeability transition pore complex
Categary Component
Go Slim No
Go Link GO:0005757
Unique Molecular Interactions 101
Total Molecular Interactions 121
Total Single Events 1306
Pain Genes Associated 3

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for mitochondrial permeability transition pore complex. They are ordered first by their pain relevance and then by number of times they were reported for mitochondrial permeability transition pore complex. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT73597 Positive_regulation of BAX Positive_regulation of Casp1 1 0.06 0.69 1.28
2 INT73598 BAX Positive_regulation of Casp1 1 0.06 0.63 1.27
3 INT296793 Akt1 Positive_regulation of Gene_expression of Bax 1 0.11 0.75 0.65
4 INT296790 Tlr9 Regulation of Bax 1 0.14 0.76 0.65
5 INT296791 Positive_regulation of Akt1 Positive_regulation of Gene_expression of Bax 1 0.11 0.8 0.65
6 INT112699 Bid Regulation of Bax 1 0.25 0.51 0.61
7 INT238638 Gopc Negative_regulation of Gene_expression of Bax 1 0.04 0.85 0.45
8 INT116613 Lnpep Negative_regulation of Gene_expression of BAX 1 0.42 0.62 0.43
9 INT116612 Lnpep Negative_regulation of BAX 1 0.42 0.62 0.42
10 INT172213 Binding of BAX and BCL2L1 3 0.22 4.02 0.35
11 INT155061 Stat3 Negative_regulation of Bax 1 0.22 3.71 0.34
12 INT163762 MDM2 Positive_regulation of Gene_expression of BAX 1 0.27 0.86 0.3
13 INT237927 BCL2 Positive_regulation of BAX 2 0.24 2.22 0.26
14 INT237919 BAX Positive_regulation of Protein_catabolism of PARP1 1 0.03 1.41 0.26
15 INT155063 Csf2 Negative_regulation of Gene_expression of Bax 1 0.27 1.46 0.18
16 INT155066 Csf2 Negative_regulation of Bax 1 0.12 1.89 0.17
17 INT349475 Regulation of Bax Regulation of Bcl2 1 0.07 1.35 0.17
18 INT155232 TXNIP Regulation of BAX 1 0.23 0.15 0.17
19 INT336891 Epo Negative_regulation of Transcription of Bax 1 0.10 0.68 0.16
20 INT349476 Bax Regulation of Bcl2 1 0.07 1.33 0.15
21 INT130918 HMHA1 Positive_regulation of BAX 1 0.04 1.37 0.14
22 INT273040 Vip Regulation of Bax 1 0.23 1.69 0.13
23 INT273041 Adcyap1 Regulation of Bax 1 0.21 1.69 0.13
24 INT226192 Protein_catabolism of Bax Positive_regulation of Gtf3a 1 0.00 0.53 0.12
25 INT285030 Binding of Bax and Slc25a4 1 0.03 0.84 0.11
26 INT265890 BCL2 Regulation of Gene_expression of BAX 1 0.04 1.08 0.1
27 INT265889 BAX Regulation of Gene_expression of BAD 1 0.06 1.08 0.1
28 INT310743 TP53 Regulation of BAX 1 0.09 1.11 0.1
29 INT285032 Bnip3 Positive_regulation of Bax 1 0.28 0.77 0.07
30 INT340401 Positive_regulation of Bax Positive_regulation of Binding of Hrk 1 0.01 0.79 0.07
31 INT340395 Binding of Bax and Tg(CAG-EGFP)D4Nagy 1 0.02 0.43 0.07
32 INT302175 BAX Regulation of Positive_regulation of CASP9 1 0.02 0.7 0.06
33 INT302129 BAX Regulation of Positive_regulation of CASP3 1 0.02 0.69 0.06
34 INT234379 BAX Positive_regulation of CASP3 1 0.04 1.16 0.04
35 INT172214 BAX Positive_regulation of TP53 1 0.09 0.37 0.04
36 INT340394 Binding of Bax and Bbc3 1 0.01 0.36 0.04
37 INT172902 Binding of Bax and Bcl2 5 0.30 3.19 0.03
38 INT297737 Cbr1 Positive_regulation of Bax 1 0.06 0.53 0.03
39 INT238395 BAX Regulation of CDKN1A 1 0.03 0.31 0.03
40 INT333259 Bcl2 Regulation of Bax 1 0.03 0.32 0.03
41 INT224676 Binding of Bax and Mcl1 1 0.01 1.09 0.03
42 INT224690 Mcl1 Regulation of Bax 1 0.00 1.09 0.03
43 INT341376 Sod2 Regulation of Bax 1 0.09 0.99 0.03
44 INT185852 Binding of BAK1 and BAX 3 0.29 2.5 0
45 INT178861 Binding of BAX and BCL2 3 0.27 3.07 0
46 INT172906 Binding of Bax and Bcl2l1 2 0.16 2.03 0
47 INT198011 Binding of BAX and MCL1 2 0.20 3.04 0
48 INT285029 Binding of Bax and Bcl2l1 1 0.25 0.1 0
49 INT330047 Binding of Bax and Bcl2l11 1 0.13 0.62 0
50 INT191058 Binding of Bcl2 and Positive_regulation of Gene_expression of Bax 1 0.21 0.49 0
51 INT327971 PNLIP Positive_regulation of Gene_expression of BAX 1 0.43 1.95 0
52 INT292500 Mlph Regulation of Gene_expression of BAX 1 0.00 0.4 0
53 INT106380 ARSA Regulation of Gene_expression of BAX 1 0.06 0.12 0
54 INT284919 XRCC6 Negative_regulation of BAX 1 0.01 0.64 0
55 INT321400 VEGFA Negative_regulation of Gene_expression of BAX 1 0.03 0.75 0
56 INT242483 Negative_regulation of Ciapin1 Negative_regulation of Positive_regulation of Bax 1 0.17 1.76 0
57 INT136914 Mapk8 Positive_regulation of Localization of Bax 1 0.51 0.12 0
58 INT322664 Prdm8 Positive_regulation of Gene_expression of Bax 1 0.01 1.1 0
59 INT327972 Negative_regulation of BCL2 Positive_regulation of BAX 1 0.22 0.82 0
60 INT285028 Binding of Bcl2 and Bax 1 0.32 0.1 0
61 INT229821 Fos Positive_regulation of Bax 1 0.15 0.27 0
62 INT309517 Binding of Bax and Xrcc6 1 0.15 0.5 0
63 INT201761 BIK Positive_regulation of Positive_regulation of Bax 1 0.01 0.43 0
64 INT113343 Phosphorylation of TP53 Positive_regulation of Gene_expression of BAX 1 0.11 0.14 0
65 INT292456 AKT1 Regulation of BAX 1 0.00 0.76 0
66 INT330052 Binding of Bax and Bid 1 0.15 0.62 0
67 INT322662 Binding of Bax and Pbrm1 1 0.08 0.9 0
68 INT172908 Binding of Bad and Bax 1 0.01 1.34 0
69 INT330057 Bid Positive_regulation of Bax 1 0.19 0.62 0
70 INT185855 Binding of BAX and BIK 1 0.29 0.65 0
71 INT313426 Positive_regulation of Ppp2ca Positive_regulation of Bax 1 0.46 0.36 0
72 INT267252 Bax Regulation of Bak1 1 0.05 1.09 0
73 INT201765 Binding of BCL2L1 and Bax 1 0.00 0.28 0
74 INT237918 BID Positive_regulation of Gene_expression of BAX 1 0.04 1.31 0
75 INT201763 BID Positive_regulation of Positive_regulation of Bax 1 0.01 0.43 0
76 INT242476 Negative_regulation of Ciapin1 Positive_regulation of Bax 1 0.19 1.29 0
77 INT185850 BID Positive_regulation of BAX 1 0.41 0.73 0
78 INT322670 Prdm8 Positive_regulation of Bax 1 0.01 1.1 0
79 INT275753 xn Regulation of Bax 1 0.05 1.31 0
80 INT333681 Trp53 Regulation of Negative_regulation of Bax 1 0.15 1.17 0
81 INT334718 Binding of NOS1 and Bax 1 0.02 0.87 0
82 INT238398 ELANE Positive_regulation of Gene_expression of BAX 1 0.05 0.47 0
83 INT292451 PTK2 Regulation of BAX 1 0.02 0.76 0
84 INT330054 Bcl2l11 Positive_regulation of Bax 1 0.25 0.62 0
85 INT187576 BAX Regulation of Gene_expression of Birc5 1 0.06 1.1 0
86 INT254090 EPO Negative_regulation of Gene_expression of Bax 1 0.10 0.63 0
87 INT340400 Binding of Bax and Mom6 1 0.04 0.28 0
88 INT327975 GOPC Regulation of Gene_expression of BAX 1 0.15 0.6 0
89 INT275746 Binding of xn and Bax 1 0.05 2.57 0
90 INT302172 Binding of BAD and BAX 1 0.06 0.93 0
91 INT340399 Binding of Bak1 and Bax 1 0.12 0.91 0
92 INT309518 Negative_regulation of Binding of Bax and Xrcc6 1 0.16 0.25 0
93 INT324908 TP53 Regulation of Gene_expression of BAX 1 0.47 1.33 0
94 INT201768 BCL2L11 Positive_regulation of Positive_regulation of Bax 1 0.00 0.43 0
95 INT318223 BAX Regulation of CASP9 1 0.09 0.18 0
96 INT237917 BID Positive_regulation of Positive_regulation of BAX 1 0.04 1.31 0
97 INT201743 Bad Positive_regulation of Positive_regulation of Bax 1 0.00 0.43 0
98 INT136915 RYBP Positive_regulation of Localization of Bax 1 0.01 0.12 0
99 INT322660 Binding of Bax and Prdm8 1 0.01 0.89 0
100 INT324909 Negative_regulation of TP53 Positive_regulation of Negative_regulation of BAX 1 0.36 1.33 0
101 INT100425 Bax Regulation of Pcbd1 1 0.06 0.06 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for mitochondrial permeability transition pore complex. They are ordered first by their pain relevance and then by number of times they were reported in mitochondrial permeability transition pore complex. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT100423 Gene_expression of Bax 141 0.75 98.43 24.48
2 INT73593 Gene_expression of BAX 173 0.76 147.81 20.94
3 INT109511 Gene_expression of Bax 133 0.78 113.22 14.36
4 INT102110 Positive_regulation of Gene_expression of Bax 42 0.67 35.77 9.51
5 INT102106 Positive_regulation of Bax 48 0.67 30.62 9.28
6 INT73596 Positive_regulation of Gene_expression of BAX 43 0.67 40.97 9.22
7 INT73595 Positive_regulation of BAX 61 0.61 56.97 7.82
8 INT102107 Negative_regulation of Gene_expression of Bax 30 0.57 29.48 7.33
9 INT98837 Positive_regulation of Bax 72 0.61 63.14 6.41
10 INT145929 Regulation of Bax 20 0.60 18.12 5.35
11 INT109513 Positive_regulation of Gene_expression of Bax 37 0.67 29.52 5.06
12 INT99504 Negative_regulation of Bax 19 0.56 8.89 4.44
13 INT101858 Negative_regulation of BAX 25 0.57 23.77 4.16
14 INT84686 Regulation of BAX 26 0.49 28.54 4.13
15 INT123752 Regulation of Bax 19 0.60 16.45 4
16 INT112692 Localization of Bax 31 0.80 20.97 3.98
17 INT124579 Localization of BAX 35 0.78 30.31 3.43
18 INT102146 Phosphorylation of Bax 4 0.66 3.48 2.35
19 INT103966 Negative_regulation of Gene_expression of BAX 9 0.56 7.95 2.14
20 INT77627 Regulation of Gene_expression of BAX 14 0.44 15.09 2.12
21 INT154970 Localization of Bax 15 0.74 11.12 2.11
22 INT98836 Transcription of Bax 6 0.69 5.04 1.96
23 INT134442 Transcription of Bax 14 0.67 7.6 1.9
24 INT135540 Negative_regulation of Bax 16 0.48 11.8 1.89
25 INT134443 Binding of Bax 10 0.47 5.62 1.84
26 INT104883 Positive_regulation of Positive_regulation of Bax 4 0.45 4.05 1.74
27 INT146785 Positive_regulation of Localization of Bax 7 0.69 6.16 1.47
28 INT109512 Negative_regulation of Gene_expression of Bax 12 0.42 8.04 1.44
29 INT112695 Negative_regulation of Protein_catabolism of Bax 3 0.36 1.72 1.3
30 INT154969 Positive_regulation of Localization of Bax 4 0.64 3.42 1.27
31 INT112693 Protein_catabolism of Bax 5 0.74 3.17 1.2
32 INT141189 Negative_regulation of Transcription of Bax 1 0.41 1.42 1.14
33 INT175507 Regulation of Gene_expression of Bax 13 0.50 10.91 0.95
34 INT98134 Binding of BAX 17 0.39 11.45 0.93
35 INT137512 Positive_regulation of Positive_regulation of BAX 5 0.49 4.91 0.85
36 INT144697 Regulation of Gene_expression of Bax 8 0.37 9.5 0.81
37 INT82896 Transcription of BAX 3 0.67 4.61 0.8
38 INT148984 Positive_regulation of Localization of BAX 6 0.48 5.29 0.77
39 INT176242 Binding of Bax 10 0.42 10.18 0.52
40 INT102108 Protein_catabolism of Bax 8 0.64 5.69 0.48
41 INT134446 Positive_regulation of Binding of Bax 1 0.49 0.72 0.48
42 INT229243 Negative_regulation of Phosphorylation of BAX 1 0.18 2.32 0.47
43 INT152059 Regulation of Transcription of Bax 1 0.26 0.07 0.42
44 INT105888 Phosphorylation of BAX 9 0.80 4.78 0.4
45 INT135802 Positive_regulation of Negative_regulation of Bax 2 0.41 0.57 0.4
46 INT229233 Positive_regulation of Phosphorylation of BAX 1 0.21 1.94 0.38
47 INT204069 Negative_regulation of Positive_regulation of Bax 5 0.31 3.08 0.34
48 INT169538 Negative_regulation of Localization of Bax 3 0.49 1.41 0.34
49 INT184482 Positive_regulation of Positive_regulation of Bax 5 0.41 4.7 0.33
50 INT221191 Negative_regulation of Localization of Bax 4 0.38 2.85 0.33
51 INT109530 Negative_regulation of Positive_regulation of BAX 3 0.42 3.01 0.3
52 INT82900 Positive_regulation of Transcription of BAX 2 0.49 1.86 0.29
53 INT102111 Positive_regulation of Protein_catabolism of Bax 2 0.45 1.14 0.27
54 INT172227 Regulation of Localization of BAX 3 0.26 4.79 0.24
55 INT135543 Negative_regulation of Positive_regulation of Bax 5 0.30 6.4 0.23
56 INT187553 Regulation of Transcription of BAX 1 0.37 1.21 0.21
57 INT300463 Regulation of Regulation of Bax 1 0.29 1.33 0.18
58 INT133486 Negative_regulation of Binding of BAX 1 0.15 0.62 0.12
59 INT336888 Negative_regulation of Transcription of Bax 1 0.07 0.68 0.11
60 INT304137 Regulation of Localization of Bax 2 0.24 1.7 0.09
61 INT303976 Negative_regulation of Protein_catabolism of BAX 1 0.09 0.24 0.07
62 INT303978 Protein_catabolism of BAX 1 0.13 0.24 0.07
63 INT307466 Positive_regulation of Phosphorylation of Bax 1 0.15 0.76 0.07
64 INT268622 Regulation of Negative_regulation of Bax 1 0.12 0.81 0.05
65 INT309494 Negative_regulation of Binding of Bax 2 0.38 1.31 0.04
66 INT172226 Positive_regulation of Negative_regulation of BAX 2 0.48 1.51 0.04
67 INT340387 Regulation of Positive_regulation of Bax 1 0.27 0.61 0.04
68 INT310746 Negative_regulation of Regulation of BAX 1 0.35 1.33 0.04
69 INT340390 Regulation of Binding of Bax 1 0.54 0.59 0.04
70 INT123525 Phosphorylation of Bax 3 0.41 1.18 0.03
71 INT302234 Negative_regulation of Localization of BAX 2 0.24 2.07 0.03
72 INT238508 Regulation of Regulation of BAX 1 0.21 1.5 0.03
73 INT176247 Positive_regulation of Phosphorylation of Bax 1 0.12 0.42 0.03
74 INT238497 Positive_regulation of Regulation of BAX 1 0.22 1.5 0.03
75 INT330041 Positive_regulation of Regulation of Bax 1 0.29 1.63 0
76 INT185897 Positive_regulation of Binding of BAX 1 0.41 0.73 0
77 INT333213 Regulation of Transcription of Bax 1 0.11 0.14 0
78 INT322640 Positive_regulation of Binding of Bax 1 0.12 0.88 0
79 INT302247 Regulation of Binding of BAX 1 0.16 1.15 0
80 INT234056 Positive_regulation of Transcription of Bax 1 0.35 0.36 0
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