GO:0005764

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Name lysosome
Categary Component
Go Slim Yes
Go Link GO:0005764
Unique Molecular Interactions 1298
Total Molecular Interactions 1634
Total Single Events 16594
Pain Genes Associated 186

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for lysosome. They are ordered first by their pain relevance and then by number of times they were reported for lysosome. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT137918 Oprm1 Positive_regulation of Pdgfrb 1 0.41 0 3.31
2 INT7190 Syt17 Positive_regulation of Ctsb 1 0.16 0 3.23
3 INT7193 Abl2 Positive_regulation of Ctsb 1 0.21 0 3.21
4 INT37162 Binding of Calca and Cckar 1 0.04 0.55 3.01
5 INT150632 Ea1 Negative_regulation of Mpo 1 0.17 1.55 2.9
6 INT103669 Hps4 Positive_regulation of Mors1 1 0.01 0 2.7
7 INT70946 Penk Positive_regulation of Hpse 1 0.34 0 2.65
8 INT253988 Binding of Cd74 and Mif 1 0.36 6.57 2.52
9 INT14687 Binding of Penk and Ppt1 1 0.41 0 2.46
10 INT7195 Negative_regulation of Syt17 Positive_regulation of Ctsb 1 0.10 0 2.25
11 INT18197 Ghrh Positive_regulation of Localization of Ggh 4 0.46 0 2.23
12 INT65025 Binding of Oprm1 and Hps4 1 0.01 0 1.93
13 INT14991 SFTPA1 Positive_regulation of Localization of MPO 1 0.11 1.65 1.92
14 INT279359 Binding of ADA and TNF 1 0.20 2.61 1.91
15 INT43447 Binding of H3 and Hps4 1 0.07 0 1.82
16 INT305741 Binding of Kcnk2 and Sort1 1 0.54 1.01 1.8
17 INT302646 ARSA Positive_regulation of TGFB1 1 0.10 0.52 1.76
18 INT30134 Binding of TPP1 and S100A9 1 0.13 0.74 1.69
19 INT102447 Binding of CALCA and CALCRL 2 0.26 0.33 1.67
20 INT288731 Binding of Got1 and Gpt 1 0.23 1.25 1.61
21 INT54601 Binding of Mtor and Ache 1 0.20 0.8 1.58
22 INT44504 Mt1a Positive_regulation of Prl 1 0.37 0 1.48
23 INT109958 Binding of CRH and HPSE 1 0.10 0.72 1.46
24 INT104972 MITF Regulation of Transcription of TYR 1 0.20 0.35 1.45
25 INT31391 Binding of PRCP and Abpa 1 0.03 0.16 1.42
26 INT298458 Binding of Calcrl and Adarb1 1 0.00 0.23 1.41
27 INT169163 Binding of Calca and Ctbs 1 0.00 0.51 1.4
28 INT299311 Binding of RPTOR and RICTOR 1 0.38 0.21 1.4
29 INT167528 Ppt1 Negative_regulation of Gene_expression of Tac4 1 0.06 0.49 1.39
30 INT167529 Ppt1 Negative_regulation of Gene_expression of Trpv1 1 0.26 0.49 1.38
31 INT106850 P2ry2 Positive_regulation of Phosphorylation of Creb1 2 0.49 0.73 1.36
32 INT115272 Neu1 Positive_regulation of Coq10a 1 0.43 0.41 1.35
33 INT115271 Neu1 Positive_regulation of Coq10a 1 0.01 0.41 1.35
34 INT299281 Binding of RPTOR and MAPKAP1 1 0.23 0.21 1.3
35 INT86518 Ass1 Positive_regulation of Hmox2 1 0.03 0.08 1.27
36 INT70181 PRCP Positive_regulation of FOS 1 0.58 0.36 1.26
37 INT42580 CAT Negative_regulation of POMC 1 0.20 0.42 1.26
38 INT172141 IL10 Negative_regulation of Gene_expression of HLA-DRA 2 0.14 0.89 1.23
39 INT7186 Trib3 Negative_regulation of Positive_regulation of Ctsb 1 0.03 0 1.21
40 INT7184 Negative_regulation of Trib3 Negative_regulation of Positive_regulation of Ctsb 1 0.03 0 1.21
41 INT301166 LRP2 Regulation of TRD@ 1 0.12 1.93 1.21
42 INT222516 Binding of Calcrl and Ramp1 5 0.17 0.11 1.12
43 INT107567 Hps4 Positive_regulation of Localization of Il1b 1 0.01 0.09 1.08
44 INT305734 Binding of Sort1 and Trpv1 1 0.01 0.5 1.08
45 INT172757 Rnpep Positive_regulation of Hps4 1 0.00 0 1.08
46 INT107564 Hps4 Regulation of Localization of Il1b 1 0.01 0.1 1.07
47 INT56990 Cat Regulation of Efs 1 0.26 0 1.05
48 INT107566 Penk Regulation of Hps4 1 0.00 0.1 1.04
49 INT7191 Negative_regulation of Abl2 Positive_regulation of Ctsb 1 0.13 0 1.04
50 INT107565 Hps4 Regulation of Mtr 1 0.00 0.1 1.04
51 INT352295 Binding of P2RY2 and Agtr1a 1 0.01 0.08 1.02
52 INT316128 TCF21 Negative_regulation of Gene_expression of HLA-DRA 1 0.07 0.13 0.99
53 INT61637 Binding of P2ry2 and Gtpbp4 1 0.02 0.1 0.99
54 INT38579 Binding of POMC and Hps4 1 0.00 0.32 0.99
55 INT130232 Binding of Cat and Sod1 1 0.35 0.3 0.98
56 INT90385 EXTL3 Regulation of Ctsl 1 0.00 1.1 0.98
57 INT130231 Positive_regulation of Binding of Cat and Sod1 1 0.46 0.3 0.98
58 INT239539 Binding of CXCR2 and CALCRL 1 0.00 0.38 0.98
59 INT153729 RYBP Positive_regulation of Slc17a5 1 0.02 0.65 0.97
60 INT25272 Binding of Ggh and Ghrh 1 0.22 0 0.97
61 INT219279 Ctss Positive_regulation of Gene_expression of Fam64a 1 0.06 1.39 0.96
62 INT219273 Fam64a Positive_regulation of Gene_expression of Ctss 1 0.06 1.39 0.96
63 INT70947 Penk Regulation of Hpse 1 0.20 0 0.96
64 INT206857 Binding of Calca and Calcrl 4 0.37 1.9 0.95
65 INT302309 Hps4 Positive_regulation of Cia1 1 0.01 1.34 0.95
66 INT70802 Ngf Regulation of Ppt1 1 0.21 0.39 0.93
67 INT161769 Cck Regulation of Cckar 1 0.27 0.53 0.92
68 INT124742 ARSA Positive_regulation of Localization of CSF2 1 0.10 0.15 0.91
69 INT141965 Binding of ADM and CALCRL 5 0.33 3.6 0.89
70 INT305742 Binding of Sort1 and Gtf3a 1 0.01 0.64 0.88
71 INT124743 ARSA Negative_regulation of PTGER2 1 0.03 0.15 0.85
72 INT194856 Positive_regulation of Adora2b Negative_regulation of Positive_regulation of Mmp13 1 0.01 0.73 0.85
73 INT124744 ARSA Negative_regulation of Gene_expression of PTGER2 1 0.03 0.15 0.85
74 INT238642 Binding of TNF and Ada 1 0.03 0.86 0.84
75 INT335644 CTSB Positive_regulation of F2RL1 1 0.02 2.58 0.82
76 INT296829 USE1 Regulation of CASP4 1 0.01 0.17 0.81
77 INT141605 Gene_expression of Ctsl Positive_regulation of Positive_regulation of MET 1 0.34 0 0.8
78 INT127383 Neo1 Regulation of Localization of Mpo 1 0.14 0.7 0.79
79 INT63588 Aap Positive_regulation of Positive_regulation of Got1 1 0.31 0.6 0.79
80 INT209043 Binding of Fn1 and Slc11a1 3 0.03 1.91 0.78
81 INT141963 Binding of CALCRL and RAMP1 2 0.43 0.81 0.78
82 INT296787 Tbrs1 Positive_regulation of Gene_expression of Tlr9 1 0.06 1.37 0.78
83 INT168457 Sult1a1 Positive_regulation of Cat 1 0.15 1.56 0.78
84 INT346133 RAMP2 Regulation of ADM 1 0.13 2.06 0.78
85 INT84466 DPP4 Regulation of Localization of Naga 1 0.00 0.87 0.78
86 INT296797 Tlr9 Regulation of Positive_regulation of TNF 1 0.03 1.37 0.77
87 INT296788 Tlr9 Regulation of Positive_regulation of Il1 1 0.07 1.37 0.77
88 INT296792 Tlr9 Regulation of Gene_expression of Il6 1 0.06 1.36 0.76
89 INT266108 Binding of COMT and HPS1 1 0.23 1.21 0.74
90 INT19577 Gabrg1 Negative_regulation of Got1 1 0.04 0.16 0.74
91 INT63589 Binding of Got1 and Gpt 1 0.36 0.56 0.74
92 INT44502 Regulation of Mt1a Positive_regulation of Prl 1 0.14 0 0.74
93 INT162241 Binding of COL7A1 and MMP13 2 0.03 0.86 0.73
94 INT331599 Tlr9 Positive_regulation of Gene_expression of Il6 1 0.03 1.8 0.73
95 INT128404 Mapk1 Positive_regulation of Phosphorylation of Gja1 1 0.65 0.73 0.73
96 INT228499 Binding of FAS and Fasl 1 0.15 2.75 0.73
97 INT157063 SLC12A1 Negative_regulation of CALCRL 1 0.00 0.34 0.73
98 INT31389 Negative_regulation of Binding of PRCP and Abpa 1 0.02 0.09 0.72
99 INT101675 Bcl2l11 Regulation of Localization of Ggh 1 0.03 0 0.72
100 INT216654 Binding of P2ry2 and DRGX 1 0.01 1.59 0.71
101 INT31390 Positive_regulation of Binding of PRCP and Abpa 1 0.04 0.08 0.71
102 INT239538 Binding of CXCR4 and CALCRL 1 0.00 0.35 0.71
103 INT121697 IL4I1 Positive_regulation of Gene_expression of MMP3 1 0.06 0.27 0.7
104 INT51705 Binding of Penk and Naga 1 0.19 0.08 0.69
105 INT102762 Binding of POMC and TYR 1 0.12 0.35 0.69
106 INT302642 Binding of ARSA and TGFB1 1 0.05 0.28 0.68
107 INT125543 Arsa Negative_regulation of Phosphorylation of Nfkbia 1 0.00 0.52 0.68
108 INT299282 PTPN3 Negative_regulation of Positive_regulation of RPTOR 1 0.07 0.48 0.67
109 INT109718 Tac1 Negative_regulation of Mpo 1 0.25 0.81 0.67
110 INT109717 Calca Negative_regulation of Mpo 1 0.16 0.8 0.67
111 INT224823 CTBS Regulation of SALL1 1 0.14 0.53 0.66
112 INT296790 Tlr9 Regulation of Bax 1 0.14 0.76 0.65
113 INT209063 Slc11a1 Positive_regulation of Il17a 1 0.11 0.4 0.65
114 INT296785 Tlr9 Regulation of Bcl2 1 0.19 0.76 0.65
115 INT216644 Binding of P2ry1 and P2ry2 1 0.24 0.55 0.64
116 INT220145 HPSE Negative_regulation of Gene_expression of CRH 1 0.01 0.92 0.64
117 INT182266 EDN1 Positive_regulation of Gene_expression of MMP13 1 0.35 2.03 0.63
118 INT333544 CTSB Regulation of Protein_catabolism of APP 1 0.01 0.53 0.62
119 INT94075 ARSA Negative_regulation of Gene_expression of IL4 1 0.28 0.26 0.62
120 INT13618 Acyp2-ps1 Negative_regulation of Localization of Ggh 1 0.07 0 0.62
121 INT79210 Hps4 Negative_regulation of Mme 1 0.00 0 0.62
122 INT333543 CTSB Regulation of APP 1 0.01 0.53 0.62
123 INT36320 PDYN Negative_regulation of Ctsb 1 0.00 0 0.61
124 INT77120 Pomc Regulation of HYAL1 1 0.01 0 0.61
125 INT31392 Binding of PRCP and Gpr37 1 0.01 0.1 0.6
126 INT178087 EDN1 Positive_regulation of MMP13 2 0.23 1.58 0.59
127 INT316674 Binding of CRP and SFTPD 1 0.16 2.02 0.59
128 INT202160 Binding of ARSD and CSF1R 1 0.16 1.69 0.59
129 INT250054 Positive_regulation of Binding of Gpr143 and Spdya 1 0.04 0.52 0.59
130 INT250053 Binding of Gpr143 and Spdya 1 0.03 0.51 0.59
131 INT125546 Arsa Negative_regulation of Gene_expression of PTGS2 1 0.00 0.53 0.58
132 INT345303 MMP15 Positive_regulation of MMP13 1 0.00 1.18 0.58
133 INT222183 Binding of HDLBP and PLA2G15 1 0.01 0.7 0.57
134 INT116787 CALCRL Regulation of Trpv1 1 0.01 0 0.56
135 INT84603 Adrb1 Regulation of Gene_expression of Aqp2 1 0.00 0 0.56
136 INT195773 Binding of Cd74 and Mif 2 0.25 2.78 0.55
137 INT131316 Tnf Positive_regulation of Mpo 1 0.29 0.65 0.55
138 INT302645 ARSA Positive_regulation of Gene_expression of TGFB1 1 0.08 0.28 0.55
139 INT144129 Prkce Positive_regulation of Phosphorylation of Gja1 1 0.42 0.48 0.55
140 INT202043 MMP13 Regulation of Protein_catabolism of COL2A1 1 0.01 0.54 0.54
141 INT18115 Binding of NPC1 and Oprd1 1 0.11 0 0.54
142 INT13191 FPR1 Positive_regulation of Localization of GUSB 1 0.31 0 0.53
143 INT13192 FPR1 Positive_regulation of Localization of LRBA 1 0.47 0 0.53
144 INT253767 Binding of Hmgb1 and Tlr9 2 0.12 1.78 0.52
145 INT144128 Binding of Gja1 and Prkce 1 0.40 0.5 0.52
146 INT275388 Binding of Lamp1 and Cxcr4 1 0.01 1.45 0.52
147 INT1006 Sst Negative_regulation of Ggh 1 0.24 0 0.52
148 INT144130 Binding of Gja1 and Prkcg 1 0.48 0.5 0.52
149 INT275387 Binding of Lamp1 and Ccr5 1 0.01 1.45 0.52
150 INT302644 ARSA Positive_regulation of Gene_expression of TGFBR1 1 0.04 0.29 0.51
151 INT346205 Binding of CD74 and TPPP 1 0.02 0.87 0.51
152 INT37583 Naga Regulation of Odc1 1 0.20 0 0.51
153 INT248135 Binding of IDS and ACCS 1 0.09 1.12 0.51
154 INT66188 Binding of ADRB2 and CDSN 1 0.01 0 0.51
155 INT334901 LDLR Positive_regulation of Crp 1 0.00 1.48 0.51
156 INT302647 ARSA Positive_regulation of TGFBR1 1 0.03 0.29 0.51
157 INT271344 MPO Regulation of Protein_catabolism of ACCS 1 0.02 2.42 0.51
158 INT23091 Tnf Positive_regulation of Localization of Ggh 1 0.05 0.15 0.5
159 INT122107 Plbd2 Negative_regulation of Cdh2 1 0.03 0.42 0.5
160 INT23089 Tnf Positive_regulation of Ggh 1 0.04 0.15 0.5
161 INT292873 Binding of Fas and Fasl 5 0.26 15.74 0.49
162 INT14992 FPR1 Positive_regulation of Localization of MPO 2 0.56 1.1 0.49
163 INT17622 Ass1 Positive_regulation of Lhb 1 0.02 1.22 0.49
164 INT288729 Positive_regulation of Binding of Got1 and Gpt 1 0.25 0.61 0.49
165 INT47226 Asap1 Regulation of Hps4 1 0.10 0.18 0.49
166 INT31531 Mif-ps1 Regulation of TYR 1 0.11 0 0.49
167 INT118485 CST3 Regulation of CTSH 1 0.36 0 0.49
168 INT302643 ARSA Positive_regulation of Localization of TGFB1 1 0.08 0.12 0.49
169 INT354986 Cacna1a Regulation of Localization of Mpo 1 0.01 1.15 0.49
170 INT165078 Binding of CTSB and Notch1 1 0.00 1.08 0.48
171 INT173597 Negative_regulation of Binding of MMP2 and Mmp13 1 0.14 0.83 0.48
172 INT88889 Binding of HSPG2 and CALCRL 1 0.00 0 0.48
173 INT58633 Negative_regulation of Il1f5 Negative_regulation of Mpo 1 0.15 0.98 0.48
174 INT173595 Binding of MMP2 and Mmp13 1 0.12 0.83 0.48
175 INT114593 Il1b Positive_regulation of Gene_expression of Ppt1 1 0.05 0.06 0.48
176 INT209046 Slc11a1 Positive_regulation of Regulation of Tlr4 1 0.07 0.09 0.48
177 INT173596 Binding of MMP3 and Mmp13 1 0.06 0.84 0.48
178 INT173598 Negative_regulation of Binding of MMP3 and Mmp13 1 0.06 0.84 0.48
179 INT65007 DAK Negative_regulation of CTSA 1 0.03 0.35 0.48
180 INT58634 Negative_regulation of Il1 Negative_regulation of Mpo 1 0.20 0.98 0.47
181 INT101003 GHRH Regulation of Localization of GGH 1 0.29 0 0.47
182 INT70183 Binding of PRCP and NCOR2 1 0.04 0.08 0.46
183 INT291018 Binding of NSF and USE1 1 0.03 0.98 0.46
184 INT195774 Binding of MIF and Cd74 1 0.02 1.15 0.46
185 INT352387 Binding of CFP and HPSE 1 0.01 1.25 0.46
186 INT296795 Binding of Tlr9 and Tlr3 2 0.22 1.29 0.45
187 INT177440 Binding of HPSE and Gnrh1 1 0.00 1.82 0.45
188 INT222923 Negative_regulation of Pde4a Negative_regulation of Positive_regulation of Mpo 1 0.04 0.59 0.45
189 INT345305 MMP14 Positive_regulation of MMP13 1 0.00 0.33 0.45
190 INT224686 S100a4 Positive_regulation of Gene_expression of Mmp13 1 0.05 0.85 0.45
191 INT191489 Positive_regulation of P2ry2 Negative_regulation of Positive_regulation of Trpv1 1 0.03 0.08 0.44
192 INT12702 Regulation of Binding of FPR1 and GUSB 1 0.43 0.18 0.44
193 INT241912 Cat Positive_regulation of Ros1 1 0.03 0.76 0.44
194 INT296827 Binding of BGN and USE1 1 0.01 0 0.44
195 INT209049 Slc11a1 Positive_regulation of Localization of Il12a 1 0.04 0.09 0.44
196 INT12703 Binding of FPR1 and GUSB 1 0.36 0.18 0.44
197 INT279360 ADA Negative_regulation of Gene_expression of IFNG 1 0.06 0.51 0.44
198 INT215564 Hmmr Negative_regulation of P2ry2 1 0.00 0 0.44
199 INT139900 Kcne2 Positive_regulation of Akt1 1 0.06 2.95 0.44
200 INT8356 Binding of YY1 and Smpd1 1 0.32 0 0.43

Single Events

The table below shows the top 100 pain related interactions that have been reported for lysosome. They are ordered first by their pain relevance and then by number of times they were reported in lysosome. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT2604 Positive_regulation of Got1 223 0.70 154.78 49.51
2 INT16364 Gene_expression of HLA-DRA 234 0.78 118.81 45.01
3 INT14575 Positive_regulation of Ppt1 60 0.70 9.97 27.4
4 INT129956 Gene_expression of MMP13 145 0.72 60.48 26.98
5 INT13415 Positive_regulation of Hpse 58 0.70 24.9 25.53
6 INT93626 Gene_expression of Fasl 118 0.75 115.24 25.11
7 INT58301 Positive_regulation of Mpo 87 0.70 80.19 23.99
8 INT37889 Gene_expression of P2ry2 75 0.65 26.01 23.8
9 INT16721 Negative_regulation of Cat 56 0.59 44.44 22.84
10 INT4890 Gene_expression of Ppt1 51 0.77 8.93 21.83
11 INT4894 Transcription of Ppt1 34 0.67 5.93 21.06
12 INT12951 Negative_regulation of Cat 126 0.57 64.39 20.61
13 INT116282 Gene_expression of Mmp13 83 0.75 45.4 20.18
14 INT6993 Negative_regulation of Mpo 72 0.59 61.83 19.51
15 INT76924 Positive_regulation of Slc17a5 71 0.70 41.21 19.31
16 INT12575 Regulation of Hpse 33 0.59 17.7 18.45
17 INT4420 Positive_regulation of GOT1 103 0.64 88.4 18.38
18 INT61519 Gene_expression of Mpo 112 0.78 89.29 18.22
19 INT9246 Positive_regulation of Cat 113 0.70 52.73 18.04
20 INT22068 Binding of CALCRL 53 0.41 6.14 17.32
21 INT3206 Positive_regulation of Got1 39 0.69 19.36 17.02
22 INT1000 Localization of Ggh 31 0.75 2.74 16.41
23 INT2480 Negative_regulation of Got1 43 0.51 14.47 16.09
24 INT14152 Gene_expression of Slc17a5 46 0.61 20.01 15.9
25 INT12950 Gene_expression of Cat 85 0.75 35.94 15.76
26 INT42810 Gene_expression of CALCRL 53 0.77 10.87 15.42
27 INT30440 Gene_expression of Hps4 15 0.29 2.39 15.31
28 INT1284 Negative_regulation of Mmp13 20 0.57 36.21 14.91
29 INT32802 Negative_regulation of Ada 21 0.57 4.03 14.87
30 INT18430 Positive_regulation of Hps4 14 0.24 0.81 14.82
31 INT61635 Positive_regulation of P2ry2 35 0.56 12.08 14.68
32 INT5904 Localization of MPO 62 0.81 36.37 14.64
33 INT8794 Negative_regulation of Ppt1 35 0.57 6.44 14.52
34 INT3623 Negative_regulation of CTSB 49 0.55 27.39 13.52
35 INT10585 Localization of NAGLU 53 0.80 23.32 12.75
36 INT123779 Positive_regulation of MMP13 42 0.65 24.3 12.45
37 INT63104 Negative_regulation of CALCRL 29 0.37 13.62 12.42
38 INT24876 Gene_expression of CD34 172 0.78 91.02 12.39
39 INT104569 Gene_expression of Aqp2 23 0.60 16.56 12.23
40 INT93620 Positive_regulation of Gene_expression of Fasl 51 0.66 59.45 12.04
41 INT16772 Gene_expression of MPO 81 0.78 90.98 11.9
42 INT149985 Gene_expression of Tlr9 32 0.75 29.83 11.86
43 INT30236 Negative_regulation of Hps4 8 0.15 1.03 11.4
44 INT5464 Regulation of CALCRL 24 0.16 4.2 11.19
45 INT15305 Positive_regulation of Mtor 51 0.67 8.28 11
46 INT22132 Positive_regulation of CAT 41 0.67 18.64 10.67
47 INT23177 Negative_regulation of Gene_expression of HLA-DRA 50 0.44 16.99 10.55
48 INT3851 Gene_expression of Got1 58 0.65 29.15 10.52
49 INT15888 Positive_regulation of Nbr1 42 0.69 35.76 10.48
50 INT6431 Positive_regulation of Ass1 36 0.24 8.08 10.43
51 INT20166 Negative_regulation of Mtor 32 0.56 10.64 10.25
52 INT79720 Positive_regulation of Cat 57 0.70 31.81 10.11
53 INT49474 Gene_expression of Hpse 24 0.55 20.11 10.03
54 INT11238 Positive_regulation of ADA 33 0.70 39.7 9.98
55 INT5465 Positive_regulation of CALCRL 25 0.49 7.24 9.8
56 INT120509 Gene_expression of Cat 65 0.77 50.9 9.75
57 INT140191 Positive_regulation of Gene_expression of Mmp13 25 0.67 13.47 9.71
58 INT105816 Gene_expression of P2RY2 53 0.78 16.47 9.67
59 INT15307 Regulation of Mtor 27 0.48 4.7 9.34
60 INT47301 Gene_expression of Ctsl 27 0.76 7.72 9.32
61 INT182137 Gene_expression of TLR9 137 0.78 48.48 9.05
62 INT18429 Localization of Hps4 8 0.31 1.23 9.01
63 INT13010 Gene_expression of TYR 38 0.65 14.81 8.84
64 INT29411 Positive_regulation of ADRB2 13 0.65 5.42 8.78
65 INT3622 Regulation of CTSB 34 0.58 16.08 8.76
66 INT129962 Positive_regulation of Gene_expression of MMP13 41 0.65 20.74 8.54
67 INT24651 Positive_regulation of Transcription of Ppt1 12 0.47 2.88 8.42
68 INT127378 Localization of Mpo 21 0.78 26.36 8.28
69 INT56223 Positive_regulation of MPO 35 0.70 43 8.2
70 INT5481 Binding of TYR 26 0.47 1.3 7.95
71 INT4663 Positive_regulation of Ada 17 0.69 9.48 7.93
72 INT5164 Negative_regulation of Ldlr 83 0.58 55.01 7.87
73 INT7168 Positive_regulation of Ctsb 9 0.70 0.3 7.58
74 INT43441 Binding of Hps4 7 0.24 0.46 7.43
75 INT91527 Gene_expression of CTSK 38 0.78 22.21 7.42
76 INT111680 Gene_expression of P2ry2 20 0.58 9.23 7.39
77 INT7883 Binding of ADRB2 18 0.47 5.49 7.37
78 INT15887 Gene_expression of Nbr1 39 0.77 23.91 7.34
79 INT76253 Positive_regulation of P2RY2 29 0.70 13.99 7.33
80 INT153794 Gene_expression of Ctsk 51 0.77 24.99 7.28
81 INT327801 Positive_regulation of Gene_expression of Aqp2 6 0.44 7.67 7.24
82 INT4228 Gene_expression of CAT 50 0.75 20.62 7.18
83 INT78199 Gene_expression of Neu1 65 0.75 62.88 7.16
84 INT5774 Regulation of Ppt1 22 0.60 4.97 7.1
85 INT10863 Positive_regulation of Ldlr 45 0.68 31.06 7.05
86 INT27916 Gene_expression of Mt1a 6 0.47 4.4 7.04
87 INT1973 Positive_regulation of NAGLU 36 0.65 14.78 7
88 INT16722 Negative_regulation of MPO 25 0.59 18.55 6.99
89 INT99942 Positive_regulation of Fasl 37 0.68 32.61 6.92
90 INT95466 Regulation of P2ry2 23 0.56 3.66 6.86
91 INT31911 Regulation of Hps4 5 0.19 2.16 6.83
92 INT4208 Regulation of Got1 23 0.44 6.72 6.62
93 INT207892 Binding of Tlr9 35 0.46 26.66 6.61
94 INT87775 Phosphorylation of Gja1 13 0.82 2.75 6.56
95 INT250050 Gene_expression of Gpr143 1 0.48 5.76 6.53
96 INT168383 Positive_regulation of Mmp13 27 0.67 17.9 6.27
97 INT11826 Positive_regulation of LDLR 62 0.62 45.09 6.21
98 INT88245 Gene_expression of Slc11a1 42 0.53 18.86 6.2
99 INT154229 Gene_expression of ARSD 22 0.57 12.5 6.19
100 INT181017 Gene_expression of Ctss 6 0.65 9.82 6.19
101 INT57562 Gene_expression of GLA 52 0.77 24.62 6.14
102 INT250048 Positive_regulation of Gpr143 12 0.43 5.85 6.1
103 INT17779 Negative_regulation of Got1 12 0.40 3.5 6.08
104 INT35780 Positive_regulation of Mt1a 9 0.55 4.9 6.08
105 INT9779 Gene_expression of Glb1 23 0.58 8.01 6.04
106 INT17551 Positive_regulation of Gene_expression of HLA-DRA 31 0.70 15.39 6
107 INT677 Positive_regulation of CST3 20 0.67 17.47 6
108 INT1002 Regulation of Localization of Ggh 10 0.58 0.63 5.98
109 INT52907 Regulation of Gene_expression of HLA-DRA 28 0.34 5.94 5.96
110 INT163540 Gene_expression of HYAL1 27 0.68 12.11 5.95
111 INT49025 Positive_regulation of TYR 14 0.69 7.15 5.84
112 INT4888 Positive_regulation of Gene_expression of Ppt1 9 0.54 2.78 5.83
113 INT1242 Negative_regulation of Slc17a5 14 0.42 4.06 5.78
114 INT29674 Gene_expression of Ada 16 0.78 4.59 5.69
115 INT3731 Negative_regulation of Neu1 17 0.39 8.35 5.67
116 INT1243 Regulation of ADRB2 16 0.54 1.84 5.66
117 INT30206 Negative_regulation of ADA 17 0.59 10.03 5.63
118 INT102836 Binding of LRP2 12 0.38 11.27 5.58
119 INT141146 Gene_expression of Mmp13 18 0.38 8.61 5.54
120 INT5903 Negative_regulation of Localization of MPO 10 0.59 5.71 5.45
121 INT118124 Binding of USE1 24 0.16 16.64 5.44
122 INT35536 Negative_regulation of CAT 26 0.57 14.39 5.38
123 INT55353 Negative_regulation of Positive_regulation of Ppt1 9 0.57 0.31 5.37
124 INT38366 Regulation of Cat 45 0.62 23.45 5.34
125 INT23725 Gene_expression of CCKAR 14 0.55 0.14 5.3
126 INT12854 Negative_regulation of Gusb 11 0.42 3.25 5.28
127 INT3550 Negative_regulation of GLA 52 0.59 33.93 5.26
128 INT102547 Gene_expression of Cd68 25 0.75 14.47 5.22
129 INT50105 Localization of CTSB 29 0.78 10.98 5.21
130 INT120511 Positive_regulation of Gene_expression of Cat 26 0.69 19.82 5.2
131 INT24080 Negative_regulation of Mtor 64 0.37 41.56 5.19
132 INT109246 Gene_expression of Calcrl 16 0.75 4.71 5.19
133 INT68202 Gene_expression of ADA 26 0.68 23.15 5.18
134 INT65554 Positive_regulation of Hpse 13 0.69 8.16 5.17
135 INT14501 Gene_expression of CST3 28 0.75 25.77 5.16
136 INT27415 Negative_regulation of Positive_regulation of Got1 15 0.51 10.99 5.14
137 INT36256 Regulation of Ada 9 0.62 4.99 5.07
138 INT9767 Negative_regulation of Ada 5 0.55 0.06 5.06
139 INT23611 Gene_expression of Mtor 23 0.66 3.57 5.02
140 INT7479 Positive_regulation of Ggh 13 0.62 5.71 5.02
141 INT3163 Gene_expression of NAGLU 28 0.75 15.23 4.98
142 INT1285 Localization of Mmp13 12 0.78 8.98 4.93
143 INT201653 Gene_expression of Sort1 6 0.75 6.29 4.89
144 INT3476 Phosphorylation of Npc1 7 0.48 0 4.84
145 INT7170 Positive_regulation of Positive_regulation of Ctsb 1 0.40 0 4.76
146 INT236335 Gene_expression of SFTPD 26 0.75 15.92 4.59
147 INT188672 Positive_regulation of Tlr9 15 0.67 13.1 4.48
148 INT112038 Positive_regulation of P2ry2 8 0.45 2.41 4.4
149 INT78524 Positive_regulation of Neu1 6 0.67 8.9 4.4
150 INT36237 Gene_expression of Ass1 11 0.24 2.31 4.38
151 INT32569 Localization of GGH 18 0.80 2.46 4.3
152 INT87780 Gene_expression of Gja1 22 0.77 5.84 4.24
153 INT129964 Negative_regulation of MMP13 23 0.55 6.48 4.21
154 INT1701 Localization of Neu1 11 0.69 6.36 4.18
155 INT149986 Positive_regulation of Gene_expression of Tlr9 5 0.67 8.18 4.15
156 INT21681 Positive_regulation of CD34 54 0.66 33.95 4.14
157 INT173910 Gene_expression of LRP2 24 0.75 19.99 4.09
158 INT30014 Positive_regulation of HPSE 22 0.70 20.91 4.09
159 INT253970 Positive_regulation of Cd74 3 0.48 8.16 4.09
160 INT47298 Localization of Ctsl 13 0.79 3.77 4.08
161 INT76227 Binding of NPC1 30 0.41 32.31 4.05
162 INT68978 Regulation of Positive_regulation of Hpse 6 0.45 1.88 4.02
163 INT183207 Negative_regulation of USE1 14 0.18 10.97 4
164 INT204529 Positive_regulation of TLR9 18 0.62 15.62 3.99
165 INT4530 Regulation of Ggh 9 0.54 2.5 3.96
166 INT134590 Localization of ADA 7 0.65 8.43 3.96
167 INT84430 Negative_regulation of Smpd1 22 0.59 10.33 3.95
168 INT14619 Positive_regulation of Localization of NAGLU 18 0.62 7.73 3.94
169 INT484 Negative_regulation of ADRB2 13 0.59 2.85 3.94
170 INT15133 Regulation of HLA-DRA 19 0.34 5.84 3.9
171 INT119330 Binding of Calcrl 8 0.37 1.96 3.85
172 INT209018 Positive_regulation of Slc11a1 11 0.55 7.12 3.83
173 INT94406 Regulation of Slc17a5 10 0.44 3.71 3.77
174 INT102452 Gene_expression of RAMP2 6 0.69 7.11 3.77
175 INT135016 Positive_regulation of Gene_expression of Slc17a5 7 0.55 4.33 3.74
176 INT149614 Localization of MMP13 13 0.81 6.12 3.65
177 INT2877 Localization of GUSB 9 0.80 0.81 3.63
178 INT31528 Regulation of TYR 6 0.44 0.83 3.63
179 INT32464 Regulation of Mmp13 12 0.44 6.46 3.61
180 INT129960 Negative_regulation of Gene_expression of MMP13 19 0.53 7.17 3.55
181 INT23728 Negative_regulation of CCKAR 6 0.42 0.48 3.53
182 INT20265 Gene_expression of Ctsb 3 0.47 1.01 3.52
183 INT55352 Regulation of Gene_expression of Ppt1 9 0.44 0.4 3.51
184 INT61734 Regulation of HPSE 16 0.60 13.05 3.5
185 INT57728 Regulation of LDLR 25 0.41 13.18 3.46
186 INT118270 Regulation of P2RY2 16 0.45 7.02 3.45
187 INT187168 Binding of Cd74 13 0.27 11.2 3.44
188 INT1970 Localization of Gusb 11 0.75 3.46 3.42
189 INT40844 Localization of Naga 2 0.53 2.88 3.42
190 INT116281 Negative_regulation of Gene_expression of Mmp13 15 0.41 9.96 3.41
191 INT126560 Binding of P2RY2 12 0.44 6.43 3.4
192 INT72798 Binding of ADA 12 0.47 7.84 3.39
193 INT13321 Negative_regulation of Hpse 11 0.56 4.64 3.39
194 INT28390 Negative_regulation of Mt1a 4 0.36 1.13 3.39
195 INT14994 Positive_regulation of Localization of MPO 12 0.70 6.85 3.37
196 INT148892 Binding of HPS1 13 0.37 19.21 3.35
197 INT111369 Transcription of Mt1a 4 0.68 1.01 3.35
198 INT87517 Gene_expression of LDLR 73 0.69 37.35 3.32
199 INT5166 Binding of Ldlr 14 0.48 11.95 3.32
200 INT133768 Regulation of Fasl 10 0.44 10.24 3.32
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