GO:0005765

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Name lysosomal membrane
Categary Component
Go Slim No
Go Link GO:0005765
Unique Molecular Interactions 390
Total Molecular Interactions 504
Total Single Events 4724
Pain Genes Associated 71

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for lysosomal membrane. They are ordered first by their pain relevance and then by number of times they were reported for lysosomal membrane. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT70946 Penk Positive_regulation of Hpse 1 0.34 0 2.65
2 INT150457 Binding of Sort1 and Prss12 3 0.21 1.36 2.64
3 INT110525 Binding of MC1R and OCA2 1 0.41 1.08 1.97
4 INT351281 AP1M2 Regulation of NCOR2 1 0.00 0.85 1.9
5 INT150456 Binding of Sort1 and Nts 3 0.45 0.64 1.79
6 INT111076 Psen1 Regulation of Psenen 1 0.17 0.76 1.58
7 INT109958 Binding of CRH and HPSE 1 0.10 0.72 1.46
8 INT115271 Neu1 Positive_regulation of Coq10a 1 0.01 0.41 1.35
9 INT94367 Binding of ARRB1 and TP53INP2 1 0.25 0 1.3
10 INT69562 Positive_regulation of AP2M1 Positive_regulation of Regulation of Adrb3 1 0.01 0.19 1.24
11 INT172141 IL10 Negative_regulation of Gene_expression of HLA-DRA 2 0.14 0.89 1.23
12 INT58140 Binding of AP2M1 and Oprm1 1 0.01 0.4 1.23
13 INT184402 Binding of HLA-DRB4 and HLA-E 1 0.00 3.1 1.19
14 INT340439 Binding of HLA-DMA and SUGT1 1 0.00 4.1 1.16
15 INT107266 Binding of HLA-DRB1 and TNF 1 0.29 1.41 1.1
16 INT107265 Binding of HLA-DRB1 and ITGAL 1 0.01 1.41 1.1
17 INT107263 Binding of HLA-DRB1 and NCR3 1 0.40 1.42 1.1
18 INT243494 Binding of Vta1 and LOC308670 1 0.01 0.06 1.06
19 INT316128 TCF21 Negative_regulation of Gene_expression of HLA-DRA 1 0.07 0.13 0.99
20 INT153729 RYBP Positive_regulation of Slc17a5 1 0.02 0.65 0.97
21 INT70947 Penk Regulation of Hpse 1 0.20 0 0.96
22 INT81329 Binding of ARRB1 and OPRK1 1 0.05 0.1 0.93
23 INT146240 Binding of AP1B1 and Mrgprc 1 0.08 0.82 0.85
24 INT340437 Binding of SERPINH1 and HLA-DRB4 1 0.00 2.26 0.84
25 INT122833 AP1B1 Regulation of Gene_expression of Fos 1 0.16 0 0.83
26 INT77393 Binding of ARRB1 and OPRM1 1 0.15 0 0.82
27 INT44503 Cubn Positive_regulation of Prl 1 0.18 0 0.74
28 INT121843 HLA-DRB5 Negative_regulation of Accn4 1 0.00 0.54 0.73
29 INT94366 Binding of ARRB1 and OPRD1 1 0.11 0 0.67
30 INT110526 OCA2 Regulation of MC1R 1 0.49 0.43 0.65
31 INT220145 HPSE Negative_regulation of Gene_expression of CRH 1 0.01 0.92 0.64
32 INT169101 Binding of HLA-A and HLA-DRB1 1 0.24 1.09 0.63
33 INT163364 Thim Regulation of Mmd 1 0.00 0.91 0.62
34 INT86405 MMD Positive_regulation of GRIN1 1 0.54 0 0.62
35 INT182819 Binding of CD63 and PECAM1 1 0.00 1.63 0.61
36 INT182815 Binding of CD63 and ICAM1 1 0.00 1.63 0.61
37 INT250054 Positive_regulation of Binding of Gpr143 and Spdya 1 0.04 0.52 0.59
38 INT250053 Binding of Gpr143 and Spdya 1 0.03 0.51 0.59
39 INT197050 Binding of HLA-DOA and HLA-E 2 0.08 1.73 0.58
40 INT77394 Binding of ARRB1 and GIPC1 1 0.01 0 0.56
41 INT18115 Binding of NPC1 and Oprd1 1 0.11 0 0.54
42 INT155898 Binding of KCNJ8 and MMD 1 0.09 0.39 0.53
43 INT275388 Binding of Lamp1 and Cxcr4 1 0.01 1.45 0.52
44 INT275387 Binding of Lamp1 and Ccr5 1 0.01 1.45 0.52
45 INT335291 SLC15A4 Negative_regulation of NFATC1 1 0.01 0.45 0.51
46 INT127337 Crh Regulation of LOC308670 1 0.01 0 0.51
47 INT159527 Binding of GDF15 and SLC17A5 1 0.14 1.15 0.51
48 INT36084 Binding of HLA-DRB4 and Igkv16-104 1 0.04 1.01 0.51
49 INT72227 Binding of BTRC and AP1M2 1 0.00 0 0.49
50 INT122832 AP1B1 Negative_regulation of Gene_expression of FLII 1 0.01 0 0.47
51 INT81330 ARRB1 Regulation of OPRK1 1 0.04 0.09 0.47
52 INT352387 Binding of CFP and HPSE 1 0.01 1.25 0.46
53 INT177440 Binding of HPSE and Gnrh1 1 0.00 1.82 0.45
54 INT45035 Binding of HLA-B and HLA-DRB4 2 0.16 0.74 0.44
55 INT157343 Binding of AQP4 and HLA-DPB1 1 0.30 0.89 0.43
56 INT340438 Binding of HLA-DMA and MRAP 1 0.02 1.69 0.43
57 INT174501 Binding of HLA-B and HLA-DOA 2 0.03 1.84 0.42
58 INT316121 IL10 Regulation of Gene_expression of HLA-DRA 1 0.09 0.46 0.42
59 INT261652 Binding of MAPK1 and PSEN1 1 0.22 1.25 0.41
60 INT184407 Binding of HLA-DRB1 and HLA-DRB4 2 0.09 2.26 0.4
61 INT38269 Binding of TCN1 and CUBN 1 0.00 0.28 0.4
62 INT184406 Binding of HLA-DRB1 and HLA-E 1 0.00 1.03 0.4
63 INT194596 Binding of HLA-DRB4 and TNFSF10 3 0.08 6 0.38
64 INT330517 Binding of CD8A and HLA-DRB4 1 0.08 0.99 0.38
65 INT116678 Binding of ARRB1 and Oxtr 1 0.13 0.15 0.38
66 INT188391 Binding of CD4 and HLA-DRB1 1 0.05 0.96 0.34
67 INT46145 HLA-DQA1 Negative_regulation of TAC1 1 0.04 0.09 0.34
68 INT28006 NPC1 Negative_regulation of Positive_regulation of Rps6ka1 1 0.01 0.37 0.33
69 INT151132 Negative_regulation of Map2k7 Negative_regulation of Gene_expression of Litaf 1 0.01 0.29 0.32
70 INT28005 NPC1 Negative_regulation of Rps6ka1 1 0.01 0.45 0.32
71 INT335307 SLC15A4 Regulation of TIMP1 1 0.01 0.69 0.29
72 INT252033 Binding of HLA-DQA2 and KLRD1 1 0.00 0.54 0.29
73 INT258861 Binding of HLA-DOA and HLA-DRB1 2 0.14 1.88 0.28
74 INT343573 Synm Positive_regulation of SLC17A5 1 0.17 1.28 0.28
75 INT316791 Binding of HLA-DRB1 and Traf1 1 0.01 0.96 0.27
76 INT45196 Cubn Negative_regulation of Prl 1 0.05 0 0.27
77 INT307009 MT1JP Positive_regulation of Gene_expression of LAMP1 1 0.03 0.58 0.26
78 INT72226 Binding of AP1M2 and EMID1 1 0.00 0 0.26
79 INT171939 Binding of HLA-DOA and TNF 1 0.05 6.8 0.26
80 INT245640 Nr3c2 Regulation of Positive_regulation of Hpse 1 0.08 0.66 0.26
81 INT355982 Binding of HLA-DQA2 and DCPS 1 0.00 1.33 0.26
82 INT72228 Negative_regulation of Binding of OPRD1 and AP1M2 1 0.04 0 0.25
83 INT297547 Pou3f3 Regulation of Psen1 1 0.00 0.41 0.25
84 INT72224 Binding of OPRD1 and AP1M2 1 0.03 0 0.25
85 INT71253 MMD Negative_regulation of Ppyr1 1 0.01 0 0.24
86 INT71254 MMD Negative_regulation of Prkaca 1 0.00 0 0.24
87 INT335346 SLC15A4 Negative_regulation of Gene_expression of Fos 1 0.02 0.23 0.23
88 INT234724 Binding of NPC1 and Cxcl1 1 0.00 0.33 0.21
89 INT167486 Positive_regulation of Binding of CD63 and ACOT1 1 0.01 0 0.21
90 INT10363 Binding of Tmem33 and RT1-Db1 1 0.00 0.92 0.21
91 INT167485 Binding of CD63 and ACOT1 1 0.00 0 0.21
92 INT139454 Binding of IGF2R and Icam1 1 0.00 0.4 0.21
93 INT262640 Binding of HLA-DQA1 and AICDA 1 0.03 5.29 0.2
94 INT171938 Binding of HLA-DOA and ATP2C1 1 0.01 3.88 0.2
95 INT353808 HLA-DMA Regulation of HLA-B 1 0.00 1.72 0.19
96 INT335311 Binding of IRF6 and SLC15A4 1 0.00 0.23 0.19
97 INT222499 Il10 Regulation of Positive_regulation of Hpse 1 0.00 0.8 0.19
98 INT75972 Binding of CD1A and CD68 1 0.03 0.45 0.18
99 INT222531 Il6 Positive_regulation of Hpse 1 0.00 0.61 0.18
100 INT271000 Binding of HLA-DPB1 and Aia1 1 0.01 1.7 0.18
101 INT222414 Tlr4 Positive_regulation of Hpse 1 0.00 0.61 0.18
102 INT316129 Binding of HLA-DRA and IL10 1 0.12 3.1 0.17
103 INT275318 Binding of Gpr143 and Adamts4 1 0.00 0.6 0.17
104 INT82391 Binding of MAPRE2 and VPS11 1 0.07 0.1 0.17
105 INT82392 Binding of OPRM1 and VPS11 1 0.25 0.1 0.17
106 INT316132 IL10 Regulation of MARCH1 1 0.11 2.12 0.17
107 INT275319 Tg(Ngf)47Kma Positive_regulation of Gpr143 1 0.00 0.59 0.17
108 INT316122 IL10 Regulation of Gene_expression of MARCH1 1 0.19 2.12 0.17
109 INT299725 AFP Positive_regulation of Positive_regulation of ACPP 1 0.00 0.78 0.17
110 INT245641 Nr3c2 Regulation of Gene_expression of Hpse 1 0.14 2.67 0.17
111 INT222505 Gene_expression of Crh Negative_regulation of Gene_expression of Hpse 1 0.02 0.55 0.17
112 INT275317 Binding of Gpr143 and Adamts5 1 0.01 0.61 0.17
113 INT316123 Binding of HLA-DRA and BCAR1 1 0.02 0.48 0.16
114 INT178269 Slc11a2 Regulation of a 1 0.06 0.97 0.16
115 INT119561 TLE4 Negative_regulation of Positive_regulation of CD1D 1 0.00 0.68 0.16
116 INT119557 CD1D Positive_regulation of IL4 1 0.00 0.67 0.16
117 INT159526 Regulation of Binding of GDF15 and SLC17A5 1 0.13 0.44 0.16
118 INT191886 Pbsn Positive_regulation of Gene_expression of Slc17a5 1 0.01 0.09 0.16
119 INT316124 TLR2 Positive_regulation of Gene_expression of HLA-DRA 1 0.14 0.34 0.16
120 INT191892 Tlr4 Positive_regulation of Gene_expression of Slc17a5 1 0.05 0.09 0.16
121 INT292615 Binding of IL6 and SLC17A5 1 0.01 1.8 0.16
122 INT119558 CD1D Positive_regulation of TNF 1 0.00 0.67 0.15
123 INT86216 Hpd Regulation of NPC1 1 0.02 0.93 0.15
124 INT94864 Regulation of Litaf Positive_regulation of Nos2 1 0.05 0.05 0.15
125 INT94865 Litaf Positive_regulation of Nos2 1 0.08 0.05 0.15
126 INT119563 CD1D Positive_regulation of IL5 1 0.01 0.67 0.15
127 INT258906 Binding of HLA-B and HLA-DRB1 1 0.31 1.36 0.15
128 INT258909 Binding of HLA-DOA and NDUFA2 1 0.03 1.44 0.15
129 INT159525 SLC17A5 Positive_regulation of Gene_expression of GDF15 1 0.14 0.42 0.15
130 INT222420 Tlr4 Positive_regulation of Positive_regulation of Hpse 1 0.00 0.67 0.15
131 INT123180 Bmp6 Positive_regulation of Lamtor1 1 0.01 0.61 0.14
132 INT188700 Il6 Positive_regulation of H2-Eb1 1 0.01 0.18 0.14
133 INT331628 Binding of HLA-DQA2 and Pain1 1 0.01 2.13 0.14
134 INT331627 Binding of HLA-DRB3 and Pain1 1 0.00 2.15 0.14
135 INT127966 GPT Positive_regulation of SLC17A5 1 0.50 1.81 0.14
136 INT204159 Slc11a2 Regulation of Gene_expression of HAMP 1 0.11 1.08 0.14
137 INT94763 PSEN2 Regulation of Positive_regulation of App 1 0.11 0.72 0.14
138 INT222551 Il6 Positive_regulation of Positive_regulation of Hpse 1 0.01 0.5 0.13
139 INT316130 IRF6 Positive_regulation of Gene_expression of HLA-DRA 1 0.02 0.27 0.13
140 INT243308 Binding of LAMP2 and BBC3 1 0.08 0.59 0.13
141 INT288701 Epas1 Regulation of Transcription of Slc11a2 1 0.29 0.38 0.13
142 INT262642 Binding of HLA-DOA and HLA-DQB3 1 0.00 0.63 0.13
143 INT311191 ecs Negative_regulation of HPSE 1 0.00 0.94 0.12
144 INT171942 Binding of HLA-DRB1 and ATP2C1 1 0.04 2.18 0.12
145 INT335300 SLC15A4 Regulation of CA2 1 0.00 0.19 0.12
146 INT298476 CD40LG Positive_regulation of HLA-DRB1 1 0.01 0.33 0.12
147 INT180345 Binding of HLA-DMA and HLA-DRB4 1 0.00 1.51 0.12
148 INT296029 Binding of HLA-DQA2 and LAG3 1 0.02 0.43 0.12
149 INT298474 IL4 Positive_regulation of HLA-DRB1 1 0.02 0.33 0.12
150 INT182154 Binding of HLA-DRA and DCPS 1 0.01 0.23 0.12
151 INT335293 SLC15A4 Regulation of NA 1 0.00 0.19 0.12
152 INT297543 Neurod1 Regulation of Psen1 1 0.00 0.2 0.12
153 INT289624 HLA-DMB Regulation of Binding of RS1 1 0.03 0.84 0.11
154 INT289629 Binding of HLA-DMB and HLA-E 1 0.10 0.84 0.11
155 INT341879 Oxt Negative_regulation of Positive_regulation of Hpse 1 0.01 0.83 0.11
156 INT210363 Binding of ALB and M6PR 1 0.00 1.19 0.1
157 INT236311 IGKV2D-38 Positive_regulation of HLA-DRB1 1 0.02 0.13 0.1
158 INT262654 Binding of HLA-DQA1 and Lmx1a 1 0.01 3.15 0.1
159 INT352303 Binding of AIF1 and CD68 1 0.01 0.71 0.1
160 INT154711 Binding of SGCG and Rnf13 1 0.36 0.76 0.1
161 INT99243 IFNG Regulation of HLA-DRA 1 0.25 0.57 0.1
162 INT186539 Crh Regulation of Hpse 1 0.09 0.52 0.1
163 INT8046 SORT1 Negative_regulation of Drd2 1 0.00 0 0.09
164 INT316131 IL10 Regulation of Regulation of HLA-DRA 1 0.09 1.31 0.09
165 INT230065 Binding of TOR1A and HLA-DOA 1 0.00 1.65 0.09
166 INT177278 Binding of HLA-DRB4 and NR1H4 1 0.02 0 0.08
167 INT186540 Binding of Cort and Hpse 1 0.05 0.92 0.08
168 INT245642 Nr3c1 Regulation of Gene_expression of Hpse 1 0.05 1.33 0.08
169 INT298351 PSMD1 Regulation of Gene_expression of HLA-DRA 1 0.01 0.42 0.08
170 INT47719 Gpr143 Regulation of Grhpr 1 0.00 0.08 0.08
171 INT234222 PSEN1 Regulation of Gene_expression of NOTCH1 1 0.03 0 0.08
172 INT316793 Binding of HLA-DRB1 and Stat4 1 0.07 0.33 0.08
173 INT193959 Psen1 Regulation of App 1 0.40 0.58 0.08
174 INT316792 Binding of HLA-DRB1 and Ptpn22 1 0.07 0.33 0.08
175 INT201543 Binding of NPC1 and RNASE1 1 0.07 1.33 0.08
176 INT302139 LAMTOR1 Regulation of CDKN2A 1 0.08 0.26 0.08
177 INT352357 CPZ Positive_regulation of Gene_expression of HLA-DRA 1 0.12 0.13 0.07
178 INT262639 Binding of HLA-DOA and AICDA 1 0.01 2.85 0.07
179 INT159461 SCN5A Negative_regulation of HPSE 1 0.00 0 0.07
180 INT159463 Ptprn2 Negative_regulation of HPSE 1 0.00 0 0.07
181 INT65158 Binding of HLA-DPB1 and Drb1 1 0.07 0.16 0.07
182 INT297246 Binding of Notch1 and Ncstn 1 0.04 0.32 0.07
183 INT297244 Regulation of Binding of Notch1 and Ncstn 1 0.05 0.32 0.07
184 INT262637 Binding of C2 and HLA-DOA 1 0.01 0.5 0.07
185 INT193954 Binding of App and Psen1 3 0.38 0.88 0.06
186 INT331310 Binding of HLA-A and HLA-DOA 1 0.00 0.85 0.06
187 INT262638 Binding of HLA-DQB1 and AICDA 1 0.03 1.34 0.06
188 INT273288 Psen1 Regulation of Prdx2 1 0.01 0.7 0.06
189 INT302160 LAMTOR1 Regulation of CDKN1A 1 0.08 0.26 0.06
190 INT330487 Binding of MME and HPSE 1 0.35 0 0.06
191 INT339099 ERBB2 Positive_regulation of IGF2R 1 0.33 0.67 0.06
192 INT302136 LAMTOR1 Regulation of CDKN1B 1 0.08 0.26 0.06
193 INT262636 Binding of HLA-DRB1 and AICDA 1 0.09 1.35 0.06
194 INT323043 Binding of CYP21A1P and HLA-DOA 1 0.04 1.48 0.06
195 INT323042 Binding of CYP21A2 and HLA-DOA 1 0.04 1.49 0.06
196 INT249416 Binding of Scarb2 and Napa 1 0.02 0 0.05
197 INT262652 Negative_regulation of Binding of HLA-DQA1 and Lmx1a 1 0.01 1.59 0.05
198 INT13519 Binding of HLA-DQA1 and HLA-DRB4 1 0.03 0.88 0.05
199 INT186185 Binding of SCARB1 and SCARB2 1 0.22 0.58 0.05
200 INT14440 Binding of GLB1 and NEU1 1 0.00 0.09 0.05

Single Events

The table below shows the top 100 pain related interactions that have been reported for lysosomal membrane. They are ordered first by their pain relevance and then by number of times they were reported in lysosomal membrane. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT16364 Gene_expression of HLA-DRA 234 0.78 118.81 45.01
2 INT13415 Positive_regulation of Hpse 58 0.70 24.9 25.53
3 INT11161 Gene_expression of HLA-DRB1 121 0.78 75.33 20.96
4 INT76924 Positive_regulation of Slc17a5 71 0.70 41.21 19.31
5 INT12575 Regulation of Hpse 33 0.59 17.7 18.45
6 INT14152 Gene_expression of Slc17a5 46 0.61 20.01 15.9
7 INT111073 Gene_expression of Psen1 167 0.76 78.65 15.83
8 INT11340 Positive_regulation of SLC17A5 120 0.67 113.52 14.5
9 INT56651 Binding of HLA-DRB1 58 0.48 52.25 13.68
10 INT23402 Binding of HLA-DOA 74 0.48 52.01 10.89
11 INT23177 Negative_regulation of Gene_expression of HLA-DRA 50 0.44 16.99 10.55
12 INT94454 Gene_expression of CD68 73 0.72 63.94 10.43
13 INT49474 Gene_expression of Hpse 24 0.55 20.11 10.03
14 INT8249 Positive_regulation of Cubn 15 0.66 4.05 9.35
15 INT13893 Negative_regulation of Cubn 9 0.36 1.78 9.24
16 INT91772 Gene_expression of PSEN1 115 0.75 38.12 8.48
17 INT74520 Positive_regulation of CD68 30 0.61 31.68 7.59
18 INT6596 Positive_regulation of HLA-DRB1 33 0.61 27.01 7.26
19 INT77404 Gene_expression of ARRB1 19 0.62 1.53 7.22
20 INT13520 Binding of HLA-DRB4 30 0.42 32.65 6.74
21 INT23246 Gene_expression of HLA-DRB4 37 0.64 36.79 6.61
22 INT250050 Gene_expression of Gpr143 1 0.48 5.76 6.53
23 INT77408 Binding of ARRB1 11 0.36 0.31 6.51
24 INT57256 Gene_expression of HLA-DQA2 52 0.55 23.87 6.27
25 INT250048 Positive_regulation of Gpr143 12 0.43 5.85 6.1
26 INT17551 Positive_regulation of Gene_expression of HLA-DRA 31 0.70 15.39 6
27 INT18967 Positive_regulation of Gene_expression of HLA-DRB1 14 0.49 13.56 5.99
28 INT52907 Regulation of Gene_expression of HLA-DRA 28 0.34 5.94 5.96
29 INT111069 Regulation of Psen1 19 0.44 7.78 5.87
30 INT60724 Gene_expression of Psen2 30 0.72 27 5.79
31 INT1242 Negative_regulation of Slc17a5 14 0.42 4.06 5.78
32 INT23401 Gene_expression of HLA-DOA 91 0.30 38.21 5.52
33 INT80657 Gene_expression of SLC17A5 50 0.75 39.98 5.44
34 INT57125 Gene_expression of AP1B1 8 0.18 3.8 4.91
35 INT94863 Gene_expression of Litaf 27 0.65 10.21 4.35
36 INT148901 Binding of Sort1 2 0.39 3.65 4.32
37 INT111067 Positive_regulation of Gene_expression of Psen1 32 0.68 21.2 4.19
38 INT1701 Localization of Neu1 11 0.69 6.36 4.18
39 INT30014 Positive_regulation of HPSE 22 0.70 20.91 4.09
40 INT76227 Binding of NPC1 30 0.41 32.31 4.05
41 INT68978 Regulation of Positive_regulation of Hpse 6 0.45 1.88 4.02
42 INT15133 Regulation of HLA-DRA 19 0.34 5.84 3.9
43 INT94406 Regulation of Slc17a5 10 0.44 3.71 3.77
44 INT135016 Positive_regulation of Gene_expression of Slc17a5 7 0.55 4.33 3.74
45 INT18822 Regulation of Cubn 4 0.27 0.17 3.74
46 INT123908 Positive_regulation of HLA-DQB1 12 0.21 10.5 3.71
47 INT61734 Regulation of HPSE 16 0.60 13.05 3.5
48 INT79477 Binding of HLA-DMA 19 0.26 13.78 3.47
49 INT148899 Regulation of Sort1 2 0.50 2.72 3.46
50 INT13321 Negative_regulation of Hpse 11 0.56 4.64 3.39
51 INT211591 Negative_regulation of PSEN1 14 0.57 5.73 3.26
52 INT28249 Positive_regulation of HLA-DRA 25 0.70 13.63 3.25
53 INT145528 Negative_regulation of Gene_expression of Slc17a5 4 0.28 2.47 3.2
54 INT80656 Regulation of SLC17A5 15 0.26 6.89 3.19
55 INT16729 Positive_regulation of LOC308670 10 0.65 1.63 3.11
56 INT91761 Gene_expression of PSEN2 38 0.75 22.93 3.03
57 INT193936 Positive_regulation of PSEN1 5 0.58 11.57 2.95
58 INT153946 Localization of Slc17a5 8 0.66 4.83 2.93
59 INT57123 Localization of AP1B1 5 0.24 1.29 2.91
60 INT69621 Positive_regulation of Positive_regulation of Hpse 7 0.42 4.1 2.85
61 INT271447 Positive_regulation of Positive_regulation of HLA-DQB1 1 0.06 5.87 2.8
62 INT59342 Negative_regulation of NPC1 20 0.44 20.21 2.79
63 INT79476 Gene_expression of HLA-DMA 23 0.38 9.5 2.76
64 INT91319 Positive_regulation of CD63 6 0.63 3.86 2.76
65 INT96338 Gene_expression of HPSE 17 0.75 18.71 2.73
66 INT106833 Positive_regulation of ARRB1 4 0.39 1.21 2.71
67 INT83642 Gene_expression of CD63 22 0.77 10.06 2.63
68 INT39266 Negative_regulation of Localization of Neu1 6 0.30 4.66 2.6
69 INT89281 Negative_regulation of Gene_expression of HLA-DRB1 10 0.30 5.9 2.55
70 INT13414 Regulation of Regulation of Hpse 4 0.16 1.71 2.55
71 INT18969 Gene_expression of HLA-DQA1 29 0.65 12.19 2.54
72 INT54720 Positive_regulation of HLA-DRB5 9 0.34 6.7 2.51
73 INT175797 Regulation of Gene_expression of Hpse 6 0.07 6.52 2.49
74 INT163544 Binding of Psen1 40 0.36 15.28 2.42
75 INT77396 Regulation of ARRB1 6 0.35 2.04 2.22
76 INT100622 Localization of CD68 16 0.73 6.58 2.2
77 INT14854 Regulation of Gene_expression of HLA-DRB1 10 0.39 5.27 2.19
78 INT195191 Gene_expression of Cubn 2 0.06 0 2.17
79 INT66881 Positive_regulation of Sort1 2 0.57 0.99 2.16
80 INT94628 Gene_expression of CD1D 12 0.75 5.58 2.13
81 INT156720 Localization of CD1D 7 0.68 1.1 2.09
82 INT181507 Positive_regulation of Psen1 22 0.49 7.59 2.04
83 INT60723 Localization of Psen2 5 0.68 2.11 2.02
84 INT77410 Positive_regulation of Gene_expression of ARRB1 3 0.55 0.21 1.98
85 INT66882 Gene_expression of Sort1 3 0.73 0.64 1.97
86 INT57339 Negative_regulation of HLA-DRA 17 0.49 7.67 1.96
87 INT88701 Gene_expression of MMD 15 0.44 6.04 1.94
88 INT72237 Binding of AP1M2 3 0.25 0 1.94
89 INT193939 Binding of PSEN1 10 0.36 6.16 1.93
90 INT57122 Positive_regulation of Localization of AP1B1 3 0.16 0.39 1.93
91 INT155015 Positive_regulation of HLA-DOA 6 0.23 4.45 1.92
92 INT351284 Regulation of Localization of AP1M2 1 0.04 0.85 1.9
93 INT41633 Positive_regulation of Positive_regulation of Cubn 2 0.48 0.1 1.89
94 INT351285 Localization of AP1M2 1 0.07 0.79 1.89
95 INT169862 Regulation of NPC1 13 0.53 13.61 1.84
96 INT2606 Localization of NEU1 10 0.41 4.6 1.82
97 INT96746 Gene_expression of Lamp1 2 0.03 1.82 1.81
98 INT111070 Negative_regulation of Gene_expression of Psen1 17 0.42 9.47 1.77
99 INT84548 Positive_regulation of HLA-DQA1 5 0.49 1.68 1.75
100 INT57124 Positive_regulation of AP1B1 4 0.19 0.94 1.74
101 INT113539 Positive_regulation of Binding of ARRB1 1 0.02 0.11 1.72
102 INT153725 Negative_regulation of Positive_regulation of Slc17a5 5 0.25 2.87 1.68
103 INT82398 Binding of HLA-DMB 3 0.35 3.82 1.66
104 INT33591 Negative_regulation of Positive_regulation of Hpse 6 0.32 3.42 1.63
105 INT74955 Negative_regulation of HPSE 6 0.57 4.75 1.57
106 INT282434 Regulation of Gene_expression of Psen1 9 0.50 2.85 1.52
107 INT150156 Positive_regulation of Gene_expression of HLA-DOA 7 0.20 4.07 1.5
108 INT189302 Positive_regulation of Gene_expression of HLA-DQA2 6 0.06 4.44 1.48
109 INT18114 Gene_expression of NPC1 45 0.66 57.85 1.44
110 INT78646 Regulation of Psen2 4 0.20 1.78 1.42
111 INT65153 Binding of HLA-DPB1 5 0.34 3.29 1.4
112 INT271448 Regulation of HLA-DQB1 1 0.06 2.73 1.4
113 INT64952 Binding of HLA-DQA2 11 0.10 7.23 1.39
114 INT181509 Negative_regulation of Psen1 17 0.57 11.53 1.35
115 INT12806 Positive_regulation of AP2M1 2 0.67 0.19 1.35
116 INT58761 Regulation of CD1D 3 0.26 1.54 1.33
117 INT89426 Binding of HLA-DRB3 2 0.41 1.77 1.32
118 INT77398 Negative_regulation of ARRB1 1 0.47 0 1.31
119 INT148638 Protein_catabolism of Hpse 1 0.48 1.09 1.28
120 INT106830 Positive_regulation of Positive_regulation of ARRB1 1 0.16 0.13 1.28
121 INT35103 Positive_regulation of Positive_regulation of SLC17A5 5 0.12 7.51 1.25
122 INT210399 Gene_expression of IGF2R 22 0.65 17.1 1.23
123 INT126907 Positive_regulation of Gene_expression of CD68 8 0.42 10.94 1.23
124 INT156383 Positive_regulation of Positive_regulation of Slc17a5 2 0.31 0.61 1.23
125 INT250046 Regulation of Gene_expression of Gpr143 1 0.28 0.87 1.23
126 INT257952 Positive_regulation of CUBN 1 0.07 0.61 1.22
127 INT151126 Negative_regulation of Gene_expression of Litaf 6 0.32 2.48 1.21
128 INT106832 Localization of ARRB1 2 0.22 0.3 1.21
129 INT16730 Negative_regulation of LOC308670 2 0.08 0.19 1.21
130 INT100621 Localization of HLA-DRA 7 0.40 2.86 1.2
131 INT44498 Localization of Cubn 2 0.34 0.38 1.19
132 INT119187 Gene_expression of HLA-DRB5 5 0.02 4.47 1.18
133 INT40736 Regulation of LOC308670 3 0.02 0.2 1.18
134 INT37679 Positive_regulation of HLA-DRB4 12 0.34 11.93 1.16
135 INT58042 Binding of HLA-DQA1 8 0.24 5.03 1.14
136 INT77411 Regulation of Gene_expression of ARRB1 3 0.36 0.61 1.12
137 INT41333 Negative_regulation of Positive_regulation of Cubn 2 0.15 0.47 1.12
138 INT161411 Positive_regulation of Localization of Slc17a5 2 0.44 1.43 1.12
139 INT175794 Negative_regulation of Gene_expression of Hpse 2 0.12 1.82 1.08
140 INT183933 Binding of CD68 8 0.31 8.74 1.06
141 INT141360 Negative_regulation of AP1B1 2 0.21 0 1.06
142 INT96229 Localization of HPSE 3 0.20 2.76 1.05
143 INT106835 Positive_regulation of Localization of ARRB1 1 0.15 0.11 1.04
144 INT148900 Localization of Sort1 1 0.44 0.5 1.01
145 INT78645 Negative_regulation of Gene_expression of Psen2 1 0.14 0.13 1.01
146 INT56098 Gene_expression of HLA-DRB3 5 0.59 2.89 0.99
147 INT110163 Binding of HLA-DQB1 8 0.25 4.71 0.98
148 INT151130 Negative_regulation of Litaf 2 0.06 0.34 0.97
149 INT106952 Positive_regulation of NPC1 23 0.43 22.9 0.94
150 INT91771 Positive_regulation of Gene_expression of PSEN1 13 0.49 8.93 0.93
151 INT151122 Positive_regulation of Litaf 7 0.35 3.58 0.92
152 INT143114 Positive_regulation of Gene_expression of HLA-DRB4 5 0.29 5.2 0.92
153 INT42425 Gene_expression of Mmd 2 0.75 1.68 0.91
154 INT92428 Regulation of Myo7a 2 0.44 1.23 0.91
155 INT58928 Gene_expression of OCA2 6 0.65 2.04 0.9
156 INT132883 Gene_expression of Slc11a2 5 0.75 2.96 0.89
157 INT55580 Localization of Hpse 5 0.23 3.51 0.89
158 INT2607 Negative_regulation of Localization of NEU1 3 0.30 1.52 0.88
159 INT139449 Negative_regulation of IGF2R 5 0.15 2.58 0.87
160 INT102352 Regulation of HLA-DQA2 3 0.03 1.92 0.87
161 INT58040 Binding of HLA-DRA 3 0.27 4.95 0.86
162 INT156966 Negative_regulation of Localization of Slc17a5 2 0.34 1.13 0.86
163 INT250045 Positive_regulation of Positive_regulation of Gpr143 1 0.31 0.4 0.85
164 INT65154 Positive_regulation of HLA-DPB1 5 0.34 1.37 0.84
165 INT24860 Positive_regulation of CD1D 6 0.49 2.13 0.83
166 INT78647 Positive_regulation of Localization of Psen2 1 0.16 0.14 0.83
167 INT102353 Positive_regulation of HLA-DQA2 6 0.06 4.07 0.82
168 INT36488 Positive_regulation of MMD 9 0.39 1.18 0.81
169 INT17916 Gene_expression of LOC308670 4 0.02 1.62 0.81
170 INT237406 Positive_regulation of Binding of Psen1 1 0.29 0 0.8
171 INT316151 Gene_expression of MARCH1 1 0.55 2.32 0.78
172 INT159531 Positive_regulation of Gene_expression of SLC17A5 8 0.49 9.3 0.77
173 INT94756 Positive_regulation of PSEN2 8 0.49 4.59 0.77
174 INT286313 Transcription of Psen1 9 0.70 2.26 0.76
175 INT193849 Positive_regulation of Gene_expression of Psen2 5 0.44 4.92 0.76
176 INT183934 Positive_regulation of Localization of CD68 1 0.38 1.83 0.76
177 INT146238 Positive_regulation of Gene_expression of AP1B1 1 0.11 0.72 0.76
178 INT276509 Positive_regulation of Positive_regulation of Sort1 1 0.41 0.22 0.76
179 INT1869 Negative_regulation of SLC17A5 12 0.42 5.51 0.75
180 INT44500 Regulation of Localization of Cubn 1 0.20 0 0.75
181 INT75105 Gene_expression of SLC15A4 3 0.19 3.33 0.74
182 INT230018 Binding of Slc17a5 2 0.21 0.86 0.74
183 INT78649 Binding of Psen2 7 0.36 5.9 0.73
184 INT119190 Positive_regulation of Gene_expression of HLA-DRB5 3 0.01 2.6 0.73
185 INT78648 Regulation of Binding of Psen2 1 0.14 0.2 0.73
186 INT151127 Regulation of Gene_expression of Litaf 3 0.18 2.1 0.72
187 INT352531 Regulation of Gene_expression of CD68 1 0.51 5.59 0.72
188 INT72654 Regulation of Localization of Neu1 1 0.02 0.34 0.72
189 INT116081 Negative_regulation of Binding of ARRB1 1 0.41 0 0.72
190 INT257951 Localization of CUBN 1 0.07 0 0.71
191 INT77406 Negative_regulation of Negative_regulation of ARRB1 1 0.47 0 0.71
192 INT28308 Localization of SLC17A5 10 0.73 6.77 0.7
193 INT59696 Gene_expression of AP2M1 1 0.65 0.23 0.7
194 INT20316 Regulation of Neu1 1 0.05 0.19 0.7
195 INT145527 Regulation of Positive_regulation of Slc17a5 1 0.39 0.14 0.7
196 INT257948 Binding of CUBN 1 0.05 0 0.7
197 INT236320 Regulation of HLA-DRB1 10 0.45 6 0.69
198 INT77401 Regulation of Regulation of ARRB1 1 0.25 0 0.69
199 INT144953 Localization of LITAF 2 0.02 1.75 0.68
200 INT257934 Negative_regulation of Gene_expression of HLA-DQA2 6 0.04 3 0.67
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