GO:0005770

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Name late endosome
Categary Component
Go Slim No
Go Link GO:0005770
Unique Molecular Interactions 690
Total Molecular Interactions 917
Total Single Events 6875
Pain Genes Associated 61

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for late endosome. They are ordered first by their pain relevance and then by number of times they were reported for late endosome. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT253988 Binding of Cd74 and Mif 1 0.36 6.57 2.52
2 INT238914 Positive_regulation of CNR1 Positive_regulation of Phosphorylation of MAPK1 1 0.19 3.22 2.35
3 INT144280 ACP1 Negative_regulation of Phosphorylation of MAPK1 1 0.37 0.78 1.56
4 INT3573 Tf Negative_regulation of Localization of Gh1 1 0.36 0 1.49
5 INT106062 Positive_regulation of Oprl1 Positive_regulation of Mapk1 1 0.13 0.16 1.35
6 INT106071 Positive_regulation of Oprl1 Positive_regulation of MAPK3 1 0.12 0.16 1.34
7 INT139736 Htr1a Positive_regulation of Mapk3 1 0.54 0.13 1.19
8 INT121191 KCNMA1 Positive_regulation of Phosphorylation of MAPK1 1 0.06 0.61 1.18
9 INT238916 CNR1 Positive_regulation of Phosphorylation of MAPK1 1 0.19 1.61 1.17
10 INT164378 MAPK3 Positive_regulation of Transcription of PDYN 1 0.50 0.2 1.09
11 INT164382 MAPK3 Positive_regulation of Gene_expression of Fos 1 0.75 0.2 1.08
12 INT164383 Positive_regulation of MAPK3 Positive_regulation of Gene_expression of Fos 1 0.54 0.2 1.08
13 INT101067 MAP3K15 Positive_regulation of MAPK1 1 0.21 0.47 1.03
14 INT229914 Egr1 Positive_regulation of Phosphorylation of Mapk3 1 0.46 1.03 1.02
15 INT140652 IGF1 Positive_regulation of Phosphorylation of MAPK1 1 0.26 0.63 0.98
16 INT133616 Map2k1 Regulation of Fadd 1 0.04 0.29 0.97
17 INT133614 Map2k1 Regulation of Daxx 1 0.02 0.29 0.97
18 INT133615 Regulation of Map2k1 Regulation of Fadd 1 0.04 0.29 0.97
19 INT100018 TNF Positive_regulation of MAPK1 3 0.24 1.56 0.94
20 INT144281 ACP1 Negative_regulation of Positive_regulation of MAPK1 1 0.27 0.58 0.94
21 INT144285 ACP1 Negative_regulation of MAPK1 1 0.37 0.58 0.93
22 INT135446 Map2k1 Positive_regulation of Mapk3 1 0.54 0.25 0.91
23 INT343918 IgG Positive_regulation of Phosphorylation of MAPK1 1 0.01 3.57 0.91
24 INT297332 Apoe Negative_regulation of Gene_expression of Mpz 1 0.02 1.09 0.87
25 INT188196 LIF Regulation of MAPK1 1 0.21 2.26 0.87
26 INT97738 Mdk Positive_regulation of Mapk3 1 0.08 0.66 0.87
27 INT188214 OSM Regulation of MAPK1 1 0.20 2.27 0.87
28 INT97735 Trib3 Positive_regulation of Mapk3 1 0.05 0.66 0.87
29 INT190183 MAPK1 Regulation of CDCP1 1 0.00 1.19 0.85
30 INT209043 Binding of Fn1 and Slc11a1 3 0.03 1.91 0.78
31 INT208354 Binding of Apoe and Hdl1 12 0.13 8.37 0.77
32 INT163830 ERBB2 Positive_regulation of MAPK1 1 0.06 1.63 0.76
33 INT128404 Mapk1 Positive_regulation of Phosphorylation of Gja1 1 0.65 0.73 0.73
34 INT772 Tf Positive_regulation of Positive_regulation of Oprl1 1 0.11 0 0.7
35 INT778 Tf Positive_regulation of Gh1 1 0.14 0 0.7
36 INT320633 Positive_regulation of MAPK1 Regulation of BCL2 1 0.04 1.21 0.7
37 INT782 Tf Positive_regulation of Prl 1 0.43 0 0.7
38 INT194685 MAPK1 Regulation of Gene_expression of IL10 1 0.06 1.18 0.7
39 INT320634 Positive_regulation of MAPK1 Regulation of PBX2 1 0.03 1.21 0.7
40 INT211915 Fig4 Positive_regulation of Mapk3 1 0.12 0.25 0.66
41 INT211916 Fig4 Positive_regulation of Mapk1 1 0.13 0.25 0.66
42 INT124477 MAP2K1 Positive_regulation of Positive_regulation of MAPK1 1 0.12 1.35 0.65
43 INT209063 Slc11a1 Positive_regulation of Il17a 1 0.11 0.4 0.65
44 INT169296 PTPLA Positive_regulation of MAPK3 1 0.10 0.15 0.63
45 INT297344 Apoe Regulation of Binding of Alms1 1 0.08 1.1 0.61
46 INT297340 Apoe Regulation of Binding of Smo 1 0.10 1.1 0.6
47 INT40901 Trf Regulation of Localization of POMC 1 0.07 0.56 0.6
48 INT223158 Mapk3 Regulation of Gene_expression of Mapk14 1 0.48 1.33 0.59
49 INT327323 Il10 Positive_regulation of Gene_expression of Ttpa 1 0.02 1.43 0.58
50 INT115146 MAPK1 Positive_regulation of EGR1 3 0.13 2.43 0.57
51 INT297331 Apoe Negative_regulation of Gene_expression of Il6 1 0.14 0.61 0.57
52 INT39210 TF Positive_regulation of Gene_expression of IL2 1 0.17 0.07 0.57
53 INT195773 Binding of Cd74 and Mif 2 0.25 2.78 0.55
54 INT201949 CXCL10 Positive_regulation of Phosphorylation of MAPK1 1 0.15 0.79 0.55
55 INT121994 EGF Positive_regulation of Positive_regulation of MAPK1 1 0.25 0 0.55
56 INT99486 OPRM1 Positive_regulation of MAPK3 1 0.22 0 0.55
57 INT144129 Prkce Positive_regulation of Phosphorylation of Gja1 1 0.42 0.48 0.55
58 INT323146 PRKCA Positive_regulation of MAPK1 1 0.02 0 0.54
59 INT85125 IL3 Positive_regulation of MAPK1 1 0.30 0.81 0.53
60 INT85121 CSF2 Positive_regulation of MAPK1 1 0.07 0.8 0.53
61 INT85115 IL5 Positive_regulation of MAPK1 1 0.14 0.81 0.53
62 INT106394 MAPK3 Positive_regulation of ADRBK1 1 0.48 0.06 0.53
63 INT144128 Binding of Gja1 and Prkce 1 0.40 0.5 0.52
64 INT171909 MAPK8 Positive_regulation of Gene_expression of MAPK1 1 0.08 1.55 0.52
65 INT254761 Igh-Dex Positive_regulation of Apoe 1 0.00 0.08 0.52
66 INT275388 Binding of Lamp1 and Cxcr4 1 0.01 1.45 0.52
67 INT171910 MAPK1 Positive_regulation of MAPK9 1 0.10 1.55 0.52
68 INT144130 Binding of Gja1 and Prkcg 1 0.48 0.5 0.52
69 INT201939 CXCL10 Positive_regulation of MAPK1 1 0.11 0.72 0.52
70 INT171906 MAPK1 Positive_regulation of Gene_expression of MAPK14 1 0.08 1.55 0.52
71 INT275387 Binding of Lamp1 and Ccr5 1 0.01 1.45 0.52
72 INT171914 MAPK8IP3 Positive_regulation of Gene_expression of MAPK1 1 0.06 1.55 0.52
73 INT122872 SEMA6A Positive_regulation of MAPK1 1 0.56 0 0.52
74 INT131368 MAPK1 Positive_regulation of Bcar3 1 0.00 0.37 0.51
75 INT131371 MAPK3 Positive_regulation of Il4 1 0.02 0.37 0.51
76 INT131367 MAPK3 Positive_regulation of Bcar3 1 0.00 0.37 0.51
77 INT131370 MAPK3 Positive_regulation of Gene_expression of Il4 1 0.02 0.37 0.51
78 INT131369 MAPK1 Positive_regulation of Il4 1 0.01 0.37 0.51
79 INT356286 Ngf Regulation of Positive_regulation of Mapk1 1 0.03 0.76 0.5
80 INT356279 Gdnf Regulation of Positive_regulation of Mapk1 1 0.03 0.76 0.5
81 INT116862 Apoe Positive_regulation of Il10 1 0.30 0.69 0.5
82 INT116863 Apoe Negative_regulation of Hand1 1 0.37 0.69 0.5
83 INT194676 Negative_regulation of MAPK1 Negative_regulation of Gene_expression of IL10 1 0.05 0.34 0.5
84 INT254768 DNMT1 Positive_regulation of Gene_expression of Apoe 1 0.02 0.05 0.49
85 INT209046 Slc11a1 Positive_regulation of Regulation of Tlr4 1 0.07 0.09 0.48
86 INT102553 HGF Positive_regulation of Phosphorylation of MAPK1 1 0.40 0.49 0.48
87 INT102552 HGF Positive_regulation of MAPK3 1 0.38 0.47 0.47
88 INT185917 Binding of AR and MAPK1 1 0.07 0.5 0.47
89 INT102555 HGF Positive_regulation of MAPK1 1 0.38 0.47 0.47
90 INT197496 Binding of Apoe and Lrp1 4 0.22 2.32 0.46
91 INT132445 TF Positive_regulation of IL8 1 0.11 2.23 0.46
92 INT69638 Binding of TF and Zfp354a 1 0.00 0 0.46
93 INT195774 Binding of MIF and Cd74 1 0.02 1.15 0.46
94 INT108332 EGF Positive_regulation of Phosphorylation of MAPK1 5 0.48 1.85 0.45
95 INT84517 IRF6 Positive_regulation of TF 1 0.14 0.19 0.44
96 INT142608 Apoe Regulation of Gene_expression of Il6 1 0.25 1.01 0.44
97 INT209049 Slc11a1 Positive_regulation of Localization of Il12a 1 0.04 0.09 0.44
98 INT343846 MAPK1 Positive_regulation of FOS 1 0.04 1.29 0.44
99 INT104447 Ido1 Negative_regulation of Binding of Atp7b 1 0.00 0.68 0.43
100 INT264473 Il1a Positive_regulation of Mapk1 1 0.00 0 0.43
101 INT188211 IL6 Regulation of MAPK1 1 0.16 1.13 0.43
102 INT264471 Il1a Positive_regulation of Gene_expression of Mapk1 1 0.01 0 0.43
103 INT106396 DYT10 Positive_regulation of MAPK3 1 0.50 0 0.42
104 INT238913 MAPK3 Regulation of Positive_regulation of MAPK1 1 0.11 0.39 0.42
105 INT254760 Igh-Dex Positive_regulation of Gene_expression of Apoe 1 0.00 0 0.42
106 INT228055 WNT1 Positive_regulation of CTNND2 1 0.54 1.75 0.42
107 INT329085 Csf2 Positive_regulation of Apoe 1 0.00 1.23 0.42
108 INT194722 Negative_regulation of MAPK1 Negative_regulation of Gene_expression of CRP 1 0.09 1.49 0.41
109 INT261652 Binding of MAPK1 and PSEN1 1 0.22 1.25 0.41
110 INT84516 NFKB1 Positive_regulation of Gene_expression of TF 1 0.10 0.09 0.41
111 INT84518 IRF6 Positive_regulation of Gene_expression of TF 1 0.14 0.09 0.41
112 INT194705 Negative_regulation of MAPK1 Negative_regulation of Positive_regulation of IK 1 0.00 1.46 0.41
113 INT58480 Agpat1 Regulation of TF 1 0.00 0.46 0.4
114 INT113474 MAPK1 Negative_regulation of TNF 1 0.13 0.23 0.4
115 INT58481 Crp Regulation of TF 1 0.01 0.46 0.4
116 INT282397 Binding of Irgm1 and Atg16l1 1 0.17 1.18 0.39
117 INT194713 MAPK1 Regulation of Gene_expression of TNF 1 0.10 1.66 0.38
118 INT84521 Binding of F7 and TF 1 0.06 0.09 0.37
119 INT340609 Bdnf Regulation of Gene_expression of Wnt3a 1 0.53 0.31 0.36
120 INT304501 Binding of Ephb1 and Mapk1 1 0.18 0.69 0.36
121 INT137625 Ntf3 Positive_regulation of Atp7b 1 0.04 0 0.36
122 INT209047 Slc11a1 Positive_regulation of Localization of Il10 1 0.10 0.52 0.36
123 INT304505 Binding of Mapk1 and Uts2d 1 0.01 0.64 0.36
124 INT272412 VSX1 Positive_regulation of Gene_expression of Slc11a1 1 0.00 0.57 0.35
125 INT174459 IL8 Positive_regulation of Gene_expression of Cd74 1 0.00 0.61 0.35
126 INT304532 Binding of Mdk and Mapk1 1 0.02 0.63 0.35
127 INT239398 Atp7b Regulation of OAP 1 0.03 1.1 0.35
128 INT304495 Trib3 Positive_regulation of Mapk1 1 0.02 1.4 0.35
129 INT304529 Negative_regulation of Binding of Mdk and Mapk1 1 0.02 0.63 0.35
130 INT144966 MAPK1 Positive_regulation of Localization of EGR1 1 0.08 0.83 0.35
131 INT167156 FPR1 Positive_regulation of MAPK1 1 0.18 0.09 0.35
132 INT291394 Gene_expression of HTT Negative_regulation of Gene_expression of Slc1a2 1 0.11 0.96 0.34
133 INT188193 Negative_regulation of EGF Positive_regulation of MAPK1 1 0.28 0.54 0.34
134 INT327308 Binding of Elavl1 and Ttpa 1 0.02 1.73 0.34
135 INT156831 EGF Positive_regulation of MAPK1 2 0.45 0.27 0.33
136 INT167155 FPR1 Positive_regulation of Phosphorylation of MAPK1 1 0.18 0.17 0.33
137 INT124475 MAP2K1 Positive_regulation of Positive_regulation of CPOX 1 0.04 0.68 0.33
138 INT100028 TNF Positive_regulation of Mapk3 1 0.22 0.79 0.32
139 INT346286 ELANE Positive_regulation of MAPK1 1 0.06 0.65 0.32
140 INT346281 Binding of ELANE and MAPK1 1 0.04 0.65 0.32
141 INT194710 MAPK1 Regulation of Gene_expression of IK 1 0.00 0.24 0.31
142 INT100029 TNF Positive_regulation of Mapk1 1 0.01 0.78 0.31
143 INT170496 Egf Positive_regulation of Mapk1 3 0.21 0.5 0.3
144 INT112797 Positive_regulation of CASP1 Positive_regulation of MAPK1 1 0.02 0.16 0.3
145 INT356287 Ngf Positive_regulation of Mapk1 1 0.05 0.17 0.3
146 INT304504 Mapk1 Positive_regulation of Nos1 1 0.29 0.93 0.3
147 INT356278 Gdnf Positive_regulation of Mapk1 1 0.05 0.17 0.3
148 INT162045 F2 Positive_regulation of Phosphorylation of MAPK3 1 0.30 0.99 0.3
149 INT112805 CASP1 Positive_regulation of MAPK1 1 0.02 0.16 0.29
150 INT130107 YY1 Positive_regulation of MAPK1 1 0.45 0 0.28
151 INT254759 Igh-Dex Positive_regulation of Localization of Apoe 1 0.00 0.32 0.28
152 INT132365 Lgals1 Positive_regulation of Mapk1 1 0.03 0.13 0.28
153 INT264472 Mapk1 Regulation of Positive_regulation of Jun 1 0.02 0 0.28
154 INT327337 MIR29A Negative_regulation of Ttpa 1 0.04 1.14 0.28
155 INT254769 Binding of LDLR and Apoe 1 0.03 0 0.28
156 INT194821 MAPK1 Regulation of Hand2 1 0.03 1.27 0.28
157 INT130106 Regulation of YY1 Positive_regulation of MAPK1 1 0.41 0 0.28
158 INT179423 Fig4 Regulation of Mapk3 1 0.02 0.32 0.28
159 INT130108 DLL3 Negative_regulation of Positive_regulation of MAPK1 1 0.13 0 0.28
160 INT291257 Map3k8 Regulation of Positive_regulation of MAPK1 1 0.09 1 0.28
161 INT172465 Binding of Rab27a and Rab27b 2 0.41 1.71 0.27
162 INT141109 Sftpa1 Positive_regulation of Mapk1 1 0.77 0.65 0.27
163 INT194682 Negative_regulation of MAPK1 Positive_regulation of Gene_expression of IL10 1 0.05 0.17 0.27
164 INT297338 Apoe Regulation of Gnb5 1 0.06 1.12 0.27
165 INT84523 TRAF3IP2 Regulation of Gene_expression of TF 1 0.05 0.1 0.27
166 INT262809 Il10 Positive_regulation of Regulation of Slc11a1 1 0.17 1.12 0.27
167 INT84519 TRAF3IP2 Positive_regulation of Gene_expression of TF 1 0.05 0.1 0.27
168 INT229785 Binding of RAB7A and SPTLC1 1 0.40 1.5 0.27
169 INT3577 Tf Negative_regulation of Positive_regulation of Gh1 1 0.49 0 0.27
170 INT262810 Slc11a1 Positive_regulation of Gene_expression of Il10 1 0.20 0.97 0.27
171 INT270256 MAPK1 Positive_regulation of Mknk1 1 0.03 0.52 0.27
172 INT188209 OSM Positive_regulation of MAPK1 1 0.35 0.47 0.27
173 INT239396 Atp7b Negative_regulation of Gene_expression of Icam1 1 0.07 1.69 0.26
174 INT307009 MT1JP Positive_regulation of Gene_expression of LAMP1 1 0.03 0.58 0.26
175 INT118849 GNA14 Positive_regulation of MAPK1 1 0.00 0.14 0.26
176 INT236005 Positive_regulation of MAPK1 Positive_regulation of Binding of Map2 1 0.04 0 0.25
177 INT254772 DNMT1 Positive_regulation of Apoe 1 0.02 0 0.25
178 INT78293 Binding of Apoe and Ldlr 1 0.20 0.25 0.24
179 INT209066 Slc11a1 Positive_regulation of Binding of TNF 1 0.01 1.11 0.24
180 INT78295 Binding of Ptpra and Apoe 1 0.42 0.25 0.24
181 INT236004 Positive_regulation of MAPK1 Positive_regulation of Phosphorylation of Map2 1 0.04 0 0.24
182 INT297334 Gnb5 Regulation of Apoe 1 0.09 0.83 0.24
183 INT261650 LGR6 Positive_regulation of MAPK1 1 0.04 0.71 0.24
184 INT78294 Negative_regulation of Binding of Ptpra and Apoe 1 0.48 0.25 0.24
185 INT226911 Slc11a1 Positive_regulation of Gene_expression of Il6 1 0.09 1.12 0.24
186 INT254773 PPARA Positive_regulation of Gene_expression of Apoe 1 0.01 0.07 0.24
187 INT78292 Negative_regulation of Binding of Apoe and Ldlr 1 0.23 0.25 0.24
188 INT144967 MAPK1 Positive_regulation of Positive_regulation of EGR1 1 0.08 0.63 0.24
189 INT132447 TF Positive_regulation of IL6 1 0.09 1.1 0.23
190 INT194702 MAPK1 Negative_regulation of Gene_expression of IL10 1 0.05 0.16 0.23
191 INT295329 ecs Positive_regulation of TF 1 0.00 1.2 0.23
192 INT254774 DNMT1 Positive_regulation of Localization of Apoe 1 0.01 0.31 0.23
193 INT17088 Binding of Ttpa and C9orf3 2 0.38 0.7 0.22
194 INT115143 MAPK1 Positive_regulation of TFAM 2 0.02 0.49 0.22
195 INT188195 GOPC Positive_regulation of MAPK1 2 0.21 0.32 0.22
196 INT283857 APOA5 Positive_regulation of Positive_regulation of MAPK1 1 0.00 0.6 0.22
197 INT298876 RAB7A Positive_regulation of Protein_catabolism of NTRK1 1 0.14 0.44 0.22
198 INT112804 IL4I1 Positive_regulation of Positive_regulation of MAPK1 1 0.03 0 0.22
199 INT194725 MAPK1 Regulation of Transcription of IK 1 0.00 0.06 0.22
200 INT141623 OLR1 Positive_regulation of Gene_expression of TF 1 0.01 1.39 0.21

Single Events

The table below shows the top 100 pain related interactions that have been reported for late endosome. They are ordered first by their pain relevance and then by number of times they were reported in late endosome. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT71789 Positive_regulation of MAPK1 396 0.70 234.44 89.27
2 INT48934 Positive_regulation of Mapk1 157 0.70 60.61 61.72
3 INT71786 Phosphorylation of MAPK1 256 0.82 110.09 46.17
4 INT48933 Gene_expression of Mapk3 93 0.75 44.39 37.92
5 INT109434 Phosphorylation of Mapk1 110 0.82 61.64 34.05
6 INT48924 Positive_regulation of Mapk3 107 0.67 50.53 34.05
7 INT48925 Gene_expression of Mapk1 95 0.74 42.21 32.91
8 INT72375 Phosphorylation of Mapk3 87 0.80 43.66 30.27
9 INT83708 Negative_regulation of MAPK1 156 0.57 84.93 27.85
10 INT116861 Gene_expression of Apoe 182 0.78 100.41 27.26
11 INT12124 Gene_expression of MAPK1 141 0.75 82.4 25.58
12 INT71781 Phosphorylation of MAPK3 62 0.80 27.73 23.73
13 INT91462 Positive_regulation of Phosphorylation of MAPK1 99 0.67 40.28 18.99
14 INT71787 Positive_regulation of MAPK3 37 0.67 17.5 17.88
15 INT75531 Regulation of MAPK1 70 0.61 34.39 15.42
16 INT128401 Positive_regulation of Positive_regulation of Mapk1 39 0.70 10.88 15.38
17 INT80688 Positive_regulation of Positive_regulation of MAPK1 72 0.69 39.35 14.11
18 INT48927 Regulation of Mapk3 25 0.60 14.06 12.82
19 INT11897 Gene_expression of Atp7b 25 0.13 7.85 12.5
20 INT75525 Negative_regulation of Positive_regulation of MAPK1 40 0.59 25.15 11.15
21 INT13240 Gene_expression of TF 94 0.76 57.81 10.99
22 INT15888 Positive_regulation of Nbr1 42 0.69 35.76 10.48
23 INT48921 Regulation of Mapk1 25 0.49 19.51 10.41
24 INT94196 Negative_regulation of Phosphorylation of MAPK1 60 0.59 31.64 9.16
25 INT340600 Gene_expression of Wnt3a 1 0.68 2.14 9.14
26 INT109432 Negative_regulation of Phosphorylation of Mapk1 19 0.54 7.01 8.98
27 INT111133 Negative_regulation of Mapk3 31 0.57 10.89 8.9
28 INT126848 Positive_regulation of Phosphorylation of Mapk1 30 0.50 15.94 8.34
29 INT71785 Gene_expression of MAPK3 22 0.75 11.35 8.21
30 INT135443 Phosphorylation of Map2k1 11 0.80 2.44 8.01
31 INT82762 Positive_regulation of Positive_regulation of Mapk3 23 0.67 7.72 7.91
32 INT135441 Positive_regulation of Map2k1 15 0.67 6.6 7.87
33 INT72372 Positive_regulation of Phosphorylation of Mapk3 30 0.67 13.6 7.69
34 INT91618 Positive_regulation of Phosphorylation of MAPK3 21 0.67 7.99 7.65
35 INT15887 Gene_expression of Nbr1 39 0.77 23.91 7.34
36 INT21938 Positive_regulation of Atp7b 26 0.10 11.33 7.1
37 INT197493 Localization of Apoe 61 0.79 27.48 7.06
38 INT142264 Positive_regulation of Apoe 47 0.50 26.35 6.94
39 INT182351 Positive_regulation of Gene_expression of Apoe 38 0.50 19.78 6.72
40 INT48928 Positive_regulation of Gene_expression of Mapk1 19 0.48 9.38 6.59
41 INT87775 Phosphorylation of Gja1 13 0.82 2.75 6.56
42 INT93137 Negative_regulation of Map2k1 17 0.42 4.51 6.49
43 INT88245 Gene_expression of Slc11a1 42 0.53 18.86 6.2
44 INT94197 Negative_regulation of Phosphorylation of MAPK3 13 0.57 5.51 6.18
45 INT48926 Positive_regulation of Gene_expression of Mapk3 12 0.46 6.02 6.13
46 INT139964 Regulation of Phosphorylation of Mapk1 12 0.58 10.04 6.1
47 INT11896 Negative_regulation of Atp7b 15 0.11 6.01 6.09
48 INT130111 Regulation of Positive_regulation of MAPK1 14 0.36 11.01 5.9
49 INT63042 Binding of Apoe 59 0.48 31.23 5.88
50 INT71779 Positive_regulation of Gene_expression of MAPK1 27 0.47 21.41 5.39
51 INT99487 Negative_regulation of MAPK3 15 0.57 7.13 5.39
52 INT135440 Positive_regulation of Phosphorylation of Map2k1 5 0.49 1.32 5.22
53 INT22597 Positive_regulation of TF 43 0.68 27.27 5.17
54 INT55758 Positive_regulation of Apoe 15 0.70 11.71 4.69
55 INT20196 Negative_regulation of Gene_expression of Atp7b 8 0.07 2.49 4.63
56 INT12194 Gene_expression of Trf 38 0.69 18.1 4.56
57 INT36767 Localization of Atp7b 11 0.20 4.13 4.5
58 INT11565 Gene_expression of Tf 24 0.68 5.89 4.36
59 INT87780 Gene_expression of Gja1 22 0.77 5.84 4.24
60 INT253970 Positive_regulation of Cd74 3 0.48 8.16 4.09
61 INT133244 Regulation of Positive_regulation of Mapk1 11 0.43 3.52 4.03
62 INT112782 Localization of Mapk3 8 0.78 1.87 3.98
63 INT106065 Negative_regulation of MAP2K1 27 0.57 12.69 3.97
64 INT179391 Phosphorylation of Map2k2 1 0.02 7.01 3.89
65 INT209018 Positive_regulation of Slc11a1 11 0.55 7.12 3.83
66 INT94291 Regulation of Gene_expression of Mapk3 4 0.40 3.05 3.8
67 INT15033 Gene_expression of Apoe 18 0.78 14.97 3.75
68 INT340603 Regulation of Gene_expression of Wnt3a 1 0.54 0.49 3.75
69 INT104624 Negative_regulation of Apoe 26 0.59 19.25 3.71
70 INT68695 Gene_expression of HTT 63 0.77 44.54 3.69
71 INT52047 Gene_expression of APOE 50 0.78 34.75 3.52
72 INT187168 Binding of Cd74 13 0.27 11.2 3.44
73 INT279383 Negative_regulation of Ttpa 2 0.06 16.02 3.37
74 INT129751 Regulation of Phosphorylation of Mapk3 11 0.55 3.91 3.35
75 INT97737 Negative_regulation of Phosphorylation of Mapk3 9 0.57 5.64 3.3
76 INT72141 Binding of Apoe 11 0.37 10.91 3.27
77 INT28583 Positive_regulation of Gene_expression of Atp7b 4 0.06 0.34 3.24
78 INT97710 Localization of Apoe 1 0.79 7.18 3.2
79 INT340595 Positive_regulation of Gene_expression of Wnt3a 1 0.61 0.86 3.11
80 INT174117 Gene_expression of Cd1d1 26 0.75 12.07 3.07
81 INT71783 Positive_regulation of Gene_expression of MAPK3 9 0.59 4.59 3.05
82 INT87288 Positive_regulation of Positive_regulation of MAPK3 5 0.67 1.62 3.04
83 INT87314 Gene_expression of Htt 112 0.78 55.82 3.03
84 INT46650 Localization of Trf 13 0.61 4.4 2.91
85 INT167039 Gene_expression of Cd74 24 0.40 17.12 2.84
86 INT200895 Localization of Mapk1 6 0.67 2.08 2.82
87 INT169112 Negative_regulation of Positive_regulation of Mapk1 9 0.59 1.84 2.78
88 INT152927 Negative_regulation of Mapk1 16 0.41 5.85 2.73
89 INT17033 Positive_regulation of Trf 21 0.62 11.76 2.68
90 INT100360 Negative_regulation of TF 19 0.42 10.43 2.68
91 INT50080 Binding of APOE 38 0.45 29.61 2.67
92 INT5432 Regulation of Atp7b 7 0.36 0.87 2.65
93 INT179396 Positive_regulation of Map2k2 7 0.30 2.84 2.56
94 INT97713 Negative_regulation of Apoe 4 0.59 4.57 2.52
95 INT327227 Gene_expression of Ttpa 1 0.08 12.08 2.52
96 INT87284 Negative_regulation of Positive_regulation of MAPK3 7 0.41 2.65 2.38
97 INT209019 Localization of Slc11a1 12 0.33 4.33 2.33
98 INT186116 Regulation of Gene_expression of MAPK1 9 0.44 5.85 2.32
99 INT31994 Negative_regulation of Nbr1 7 0.41 5.54 2.29
100 INT208344 Positive_regulation of Localization of Apoe 22 0.48 9.6 2.27
101 INT142265 Regulation of Apoe 20 0.60 9.52 2.23
102 INT209027 Positive_regulation of Positive_regulation of Slc11a1 3 0.14 2.41 2.18
103 INT96841 Regulation of Slc11a1 9 0.36 6.83 2.14
104 INT87778 Positive_regulation of Gene_expression of Gja1 6 0.69 1.46 2.14
105 INT141833 Gene_expression of WNT1 14 0.75 10.57 2.1
106 INT170482 Regulation of Gene_expression of Mapk1 5 0.43 5.73 2.1
107 INT84060 Regulation of Apoe 4 0.62 3.33 2.05
108 INT109906 Localization of MAPK1 12 0.54 1.68 2.01
109 INT83709 Negative_regulation of Gene_expression of MAPK1 12 0.41 6.57 2.01
110 INT29035 Negative_regulation of Wnt1 3 0.41 1.47 2
111 INT16710 Negative_regulation of Slc30a2 4 0.24 0 1.96
112 INT87779 Positive_regulation of Gja1 4 0.53 0.9 1.95
113 INT157305 Gene_expression of Map1lc3a 47 0.75 18.04 1.93
114 INT83329 Regulation of Gene_expression of Tf 4 0.16 1.83 1.93
115 INT253975 Binding of Cd74 4 0.27 4.57 1.88
116 INT87776 Positive_regulation of Phosphorylation of Gja1 3 0.62 0.71 1.86
117 INT36499 Negative_regulation of Tf 6 0.38 3.02 1.85
118 INT78665 Gene_expression of Irgm1 12 0.65 3.17 1.83
119 INT118683 Regulation of Phosphorylation of MAPK3 3 0.44 2.92 1.82
120 INT96746 Gene_expression of Lamp1 2 0.03 1.82 1.81
121 INT82760 Negative_regulation of Positive_regulation of Mapk3 7 0.57 3.18 1.78
122 INT135444 Regulation of Map2k1 4 0.44 1.15 1.77
123 INT96842 Binding of Slc11a1 16 0.34 7.15 1.66
124 INT87282 Regulation of MAPK3 9 0.60 7.61 1.65
125 INT96814 Negative_regulation of APOE 13 0.59 10.64 1.61
126 INT38998 Negative_regulation of Localization of Atp7b 4 0.11 1.72 1.6
127 INT179420 Positive_regulation of Phosphorylation of Map2k2 1 0.01 2.17 1.58
128 INT37005 Regulation of Nbr1 6 0.24 6.33 1.56
129 INT82761 Regulation of Positive_regulation of Mapk3 3 0.40 1.34 1.52
130 INT130019 Regulation of Phosphorylation of MAPK1 6 0.49 3.6 1.5
131 INT54593 Positive_regulation of Gene_expression of TF 16 0.68 9.05 1.43
132 INT104121 Positive_regulation of MAP2K1 8 0.61 4.84 1.41
133 INT217388 Negative_regulation of Gene_expression of Apoe 11 0.59 6.07 1.4
134 INT153627 Binding of Mapk1 5 0.36 2.88 1.4
135 INT271443 Regulation of Cd74 1 0.33 2.73 1.4
136 INT340596 Negative_regulation of Gene_expression of Wnt3a 1 0.51 0.38 1.4
137 INT71782 Gene_expression of MAP2K1 7 0.68 3.17 1.37
138 INT97716 Transcription of Apoe 3 0.53 2.61 1.36
139 INT16239 Negative_regulation of Trf 9 0.32 4.06 1.35
140 INT104027 Negative_regulation of Negative_regulation of MAPK1 6 0.56 2.87 1.35
141 INT229794 Positive_regulation of RAB7A 2 0.65 11.68 1.31
142 INT67006 Positive_regulation of TTPA 5 0.49 2.31 1.29
143 INT36500 Negative_regulation of Gene_expression of Tf 4 0.38 1.22 1.29
144 INT100515 Positive_regulation of Slc30a2 2 0.46 0.1 1.29
145 INT97715 Regulation of Gene_expression of Apoe 3 0.62 1.98 1.23
146 INT113336 Positive_regulation of Gene_expression of Apoe 3 0.70 1.79 1.23
147 INT132453 Binding of TF 31 0.36 12.98 1.22
148 INT327244 Negative_regulation of Gene_expression of Ttpa 1 0.06 5.23 1.22
149 INT229791 Gene_expression of RAB7A 2 0.73 6.48 1.21
150 INT141834 Negative_regulation of Gene_expression of WNT1 3 0.57 1.31 1.2
151 INT36443 Regulation of Trf 4 0.61 1.65 1.18
152 INT769 Regulation of Tf 3 0.30 1 1.18
153 INT229792 Negative_regulation of Positive_regulation of RAB7A 1 0.40 1.49 1.17
154 INT178480 Positive_regulation of Irgm1 7 0.13 5.91 1.15
155 INT327285 Phosphorylation of Ttpa 1 0.09 4.72 1.15
156 INT238919 Regulation of Gene_expression of MAPK3 3 0.16 1.6 1.13
157 INT108997 Localization of Htt 28 0.77 3.76 1.07
158 INT217390 Negative_regulation of Positive_regulation of Apoe 3 0.37 1.95 1.05
159 INT90898 Negative_regulation of Rab27a 5 0.43 1.99 1.04
160 INT164381 Regulation of Positive_regulation of MAPK3 2 0.60 1.49 1.03
161 INT134822 Gene_expression of Gja1 18 0.72 4.2 1
162 INT3568 Localization of Tf 4 0.62 1.27 1
163 INT28582 Positive_regulation of Positive_regulation of Atp7b 1 0.04 0.1 1
164 INT97714 Negative_regulation of Localization of Apoe 1 0.58 1.83 0.97
165 INT254875 Positive_regulation of Htt 10 0.47 4.07 0.96
166 INT151946 Positive_regulation of Regulation of Mapk3 1 0.16 1.31 0.96
167 INT22456 Localization of Nbr1 4 0.70 2.71 0.95
168 INT340604 Regulation of Wnt3a 1 0.24 0 0.95
169 INT137807 Binding of Cd1d1 4 0.31 1.26 0.94
170 INT22455 Binding of Nbr1 8 0.21 10.57 0.93
171 INT13241 Negative_regulation of Gene_expression of TF 7 0.57 3.03 0.93
172 INT142495 Regulation of LGMN 2 0.14 0.13 0.91
173 INT68692 Regulation of HTT 8 0.60 4.06 0.89
174 INT132883 Gene_expression of Slc11a2 5 0.75 2.96 0.89
175 INT116058 Gene_expression of Cd74 2 0.56 0.55 0.89
176 INT19637 Localization of TF 14 0.73 5.74 0.86
177 INT157303 Positive_regulation of Gene_expression of Map1lc3a 15 0.53 4.12 0.85
178 INT89368 Positive_regulation of Tf 7 0.34 3.62 0.83
179 INT141835 Negative_regulation of WNT1 2 0.41 1.02 0.83
180 INT202628 Gene_expression of Wnt1 20 0.67 9.2 0.82
181 INT154886 Gene_expression of Htt 18 0.76 15.51 0.82
182 INT32188 Regulation of Atp7b 7 0.04 3.01 0.81
183 INT174420 Positive_regulation of Gene_expression of Cd74 3 0.20 1.92 0.81
184 INT71778 Positive_regulation of Gene_expression of MAP2K1 2 0.36 0.37 0.81
185 INT87777 Regulation of Gja1 1 0.62 0.76 0.81
186 INT142597 Regulation of Binding of Apoe 1 0.34 2.21 0.8
187 INT157302 Positive_regulation of Map1lc3a 27 0.66 11.31 0.79
188 INT121334 Binding of HTT 11 0.47 6.66 0.78
189 INT88814 Gene_expression of TTPA 5 0.14 2.35 0.76
190 INT194780 Regulation of Negative_regulation of MAPK1 3 0.32 3.42 0.76
191 INT167081 Binding of Mapk3 2 0.29 0.27 0.76
192 INT211909 Regulation of Positive_regulation of Map2k1 1 0.21 0.47 0.76
193 INT211908 Regulation of Positive_regulation of Map2k2 1 0.27 0.48 0.76
194 INT143306 Positive_regulation of Gja1 3 0.50 0.42 0.75
195 INT90899 Gene_expression of Rab27a 49 0.78 26.71 0.74
196 INT197495 Negative_regulation of Localization of Apoe 6 0.43 2.19 0.73
197 INT128402 Negative_regulation of Phosphorylation of Gja1 1 0.58 0.73 0.73
198 INT44612 Positive_regulation of APOE 16 0.67 5.73 0.72
199 INT229789 Regulation of RAB7A 4 0.42 7.09 0.72
200 INT282385 Binding of Irgm1 2 0.20 3.18 0.7
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