GO:0005783

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Name endoplasmic reticulum
Categary Component
Go Slim Yes
Go Link GO:0005783
Unique Molecular Interactions 6091
Total Molecular Interactions 8050
Total Single Events 74243
Pain Genes Associated 680

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for endoplasmic reticulum. They are ordered first by their pain relevance and then by number of times they were reported for endoplasmic reticulum. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT221180 Binding of OPRM1 and Flna 1 0.09 0.22 12.65
2 INT206768 TP53 Positive_regulation of Ltp 2 0.01 5.83 10.21
3 INT98346 Negative_regulation of Binding of CPOX and PTGS1 1 0.10 2.91 6.54
4 INT251170 Clu Positive_regulation of Trpv1 1 0.28 2.61 6.49
5 INT169218 Binding of EGFR and Coc 1 0.06 2.8 5.85
6 INT296275 Binding of Dlg4 and Kcnip3 1 0.39 3.58 5.6
7 INT296484 Binding of Gria2 and GRIP1 1 0.04 4.52 4.59
8 INT51497 Cck Negative_regulation of Localization of Trim13 1 0.34 0 4.53
9 INT7022 Drd1a Positive_regulation of Npr1 6 0.05 0.26 4.32
10 INT107801 Ugt1a5 Positive_regulation of Localization of Prl 3 0.76 1 3.9
11 INT113080 Drd1a Positive_regulation of Phosphorylation of Creb1 2 0.27 0.43 3.88
12 INT220623 Binding of Stat1 and Bace1 11 0.25 10.33 3.81
13 INT134284 Binding of OPRM1 and PLD2 1 0.52 0 3.72
14 INT322411 Hist1h1t Positive_regulation of Positive_regulation of OPRM1 1 0.00 1.25 3.63
15 INT349583 Aap Positive_regulation of Gene_expression of Cyp2e1 1 0.18 1.57 3.59
16 INT195931 Binding of OPRM1 and Trpv1 1 0.07 0.87 3.43
17 INT152035 Binding of HLA-A and MRAP 2 0.31 6.95 3.4
18 INT48162 RIMS3 Regulation of Localization of LTC4S 1 0.10 2.14 3.25
19 INT349584 Binding of Cyp2e1 and Aap 1 0.10 1.56 3.24
20 INT37162 Binding of Calca and Cckar 1 0.04 0.55 3.01
21 INT118158 Binding of Prkca and Prkcz 1 0.07 1.14 2.98
22 INT349589 Aap Positive_regulation of Cyp2e1 1 0.21 1.84 2.71
23 INT318474 Positive_regulation of OPRM1 Positive_regulation of Localization of CA2 1 0.17 0.55 2.7
24 INT91350 Binding of Pla2g4a and RYBP 1 0.00 1.15 2.65
25 INT150457 Binding of Sort1 and Prss12 3 0.21 1.36 2.64
26 INT351444 Grin1 Positive_regulation of Gria2 1 0.22 1.5 2.64
27 INT167769 Prkca Positive_regulation of Positive_regulation of Sigmar1 1 0.38 0.86 2.63
28 INT152113 Binding of NTSR1 and Ngf 3 0.33 2.09 2.62
29 INT104219 SCD Positive_regulation of Cnr1 1 0.00 2.67 2.54
30 INT42727 Binding of Oprm1 and Trim13 1 0.14 0 2.54
31 INT104218 SCD Positive_regulation of CNR2 1 0.01 2.67 2.54
32 INT253988 Binding of Cd74 and Mif 1 0.36 6.57 2.52
33 INT156799 Gria1 Regulation of Grm8 1 0.11 1.29 2.45
34 INT147659 Prkce Positive_regulation of TRPV1 1 0.04 1.42 2.43
35 INT81657 Binding of CPOX and PTGS1 5 0.15 1.9 2.37
36 INT284860 Binding of Pdzd2 and Nav1 9 0.29 2.33 2.34
37 INT88730 Binding of OPRM1 and Mop3 1 0.00 0 2.34
38 INT322410 Hist1h1t Positive_regulation of Phosphorylation of OPRM1 1 0.00 0.08 2.31
39 INT321474 Binding of Slc6a2 and Ubqln1 1 0.00 0.8 2.27
40 INT321477 Binding of Ubqln1 and Flvcr2 1 0.00 0.81 2.26
41 INT85252 Negative_regulation of Chi3l1 Positive_regulation of Casp3 1 0.01 0 2.26
42 INT85251 Chi3l1 Positive_regulation of Casp3 1 0.01 0 2.25
43 INT251164 Binding of Clu and Trpv1 1 0.19 0.44 2.23
44 INT155984 Il1a Negative_regulation of Gene_expression of Cyp3a11 1 0.24 0.92 2.2
45 INT146520 Tmem132a Regulation of Gene_expression of Fos 1 0.69 0.5 2.18
46 INT318473 Positive_regulation of OPRM1 Positive_regulation of CA2 1 0.17 0.46 2.13
47 INT18593 Binding of Sst and Fdft1 2 0.11 0.08 2.12
48 INT77807 Edn1 Positive_regulation of Gene_expression of Ptgs2 1 0.33 0.53 2.1
49 INT51198 Positive_regulation of Binding of OPRM1 and PDYN 2 0.18 0.3 2.08
50 INT51199 Binding of OPRM1 and PDYN 2 0.13 0.3 2.08
51 INT296277 Binding of Car2 and Kcnip3 5 0.18 1.09 2.06
52 INT121216 Prkca Regulation of Positive_regulation of Oprd1 1 0.02 0.32 2.02
53 INT53751 Positive_regulation of Cyp2e1 Positive_regulation of RYBP 1 0.14 0.89 1.98
54 INT113572 Binding of DMRT1 and OPRM1 1 0.01 0 1.9
55 INT129903 Nr1i2 Regulation of Cyp3a11 1 0.64 1.26 1.9
56 INT135582 Prok2 Positive_regulation of Localization of Prkce 1 0.06 1.02 1.87
57 INT297488 Itpr3 Regulation of Positive_regulation of Ltp 1 0.02 0.47 1.87
58 INT169468 Binding of Egfr and Spink3 1 0.37 3.73 1.83
59 INT7023 Negative_regulation of Drd1a Positive_regulation of Npr1 2 0.05 0.1 1.81
60 INT121218 Arrb2 Regulation of Negative_regulation of Prkca 1 0.17 0.23 1.8
61 INT305741 Binding of Kcnk2 and Sort1 1 0.54 1.01 1.8
62 INT150456 Binding of Sort1 and Nts 3 0.45 0.64 1.79
63 INT115048 Kcnip3 Regulation of Gene_expression of Pdyn 2 0.27 0.71 1.78
64 INT167319 Binding of OPRM1 and PCSK2 1 0.22 0.63 1.77
65 INT167320 Binding of CPE and OPRM1 1 0.14 0.63 1.77
66 INT167321 Binding of ENG and OPRM1 1 0.27 0.63 1.76
67 INT146512 Tmem132a Negative_regulation of Gene_expression of Fos 1 0.23 0 1.76
68 INT129953 Oprd1 Regulation of Cspg5 1 0.17 0.15 1.74
69 INT167765 Prkca Positive_regulation of Sigmar1 1 0.41 0.63 1.74
70 INT157524 Binding of GRM5 and OPRM1 1 0.36 0 1.74
71 INT92369 Binding of CYP2D6 and RYBP 1 0.25 0.15 1.73
72 INT139156 Binding of Gria1 and Gria2 1 0.23 0.64 1.72
73 INT169464 Akt1 Positive_regulation of Egfr 1 0.28 1.63 1.7
74 INT70148 Drd1a Positive_regulation of Localization of Acot1 1 0.14 0 1.7
75 INT80199 Ngf Regulation of Transcription of Rab38 1 0.01 1.48 1.68
76 INT102447 Binding of CALCA and CALCRL 2 0.26 0.33 1.67
77 INT139433 Binding of Prkaca and Prkca 1 0.37 0.13 1.67
78 INT101926 Binding of Dio1 and Drd2 4 0.28 0.39 1.66
79 INT142437 Urb1 Negative_regulation of Faah 3 0.41 2.12 1.66
80 INT83093 IL1B Positive_regulation of BDKRB1 1 0.51 0.44 1.65
81 INT134742 Binding of OPRM1 and SV2A 1 0.33 0.18 1.64
82 INT135516 PRKCA Negative_regulation of Phosphorylation of OPRM1 1 0.12 0 1.62
83 INT32937 Binding of Pgrmc1 and Dtnb 1 0.20 0 1.61
84 INT109739 Binding of ITPA and Pcyt1b 1 0.16 0.72 1.6
85 INT195930 OPRM1 Regulation of Prkaca 1 0.01 0 1.59
86 INT326509 Binding of ACE and VWF 1 0.05 2.07 1.59
87 INT111076 Psen1 Regulation of Psenen 1 0.17 0.76 1.58
88 INT342993 PHEX Regulation of Protein_catabolism of SFTPA1 1 0.00 2.84 1.58
89 INT118515 Positive_regulation of PRKCA Positive_regulation of Phosphorylation of TRPV1 1 0.27 0.56 1.58
90 INT54601 Binding of Mtor and Ache 1 0.20 0.8 1.58
91 INT221182 Negative_regulation of Binding of OPRM1 and Flna 1 0.07 0 1.57
92 INT116093 OPRM1 Positive_regulation of Positive_regulation of NFKB1 1 0.36 0.08 1.56
93 INT100784 RYBP Positive_regulation of CYP3A4 1 0.44 0 1.54
94 INT66713 Binding of BDKRB1 and KNG1 2 0.22 0.39 1.53
95 INT351366 LPA Positive_regulation of Rab38 1 0.00 0.95 1.53
96 INT63490 Negative_regulation of Dio1 Positive_regulation of Rtcd1 1 0.01 0.58 1.51
97 INT63489 Dio1 Positive_regulation of Rtcd1 1 0.01 0.58 1.51
98 INT166676 Binding of PRKCA and UGT1A6 1 0.30 0 1.5
99 INT136844 Binding of Prkca and Nrgn 1 0.33 0 1.47
100 INT156008 Bcl2 Regulation of Localization of Aifm1 1 0.17 1.92 1.47
101 INT161870 OPRM1 Positive_regulation of Prkcg 1 0.01 0.12 1.47
102 INT201950 IFNA1 Positive_regulation of Binding of DPP4 1 0.12 2.17 1.47
103 INT123899 Binding of CYP3A4 and UGT2B7 1 0.52 0 1.46
104 INT141676 OPRM1 Positive_regulation of Ltp 1 0.04 0 1.46
105 INT201946 IFNA1 Positive_regulation of DPP4 1 0.17 2.16 1.46
106 INT141675 OPRM1 Positive_regulation of Negative_regulation of Ltp 1 0.04 0 1.46
107 INT72755 Tap1 Negative_regulation of TNF 1 0.43 2.45 1.46
108 INT190773 Il4 Negative_regulation of Gene_expression of Ptgs2 1 0.06 1.26 1.45
109 INT190774 Il4 Negative_regulation of Positive_regulation of Ptgs2 1 0.06 1.26 1.45
110 INT161858 OPRM1 Positive_regulation of GRIN1 1 0.50 0.12 1.45
111 INT221242 Ros1 Positive_regulation of Prkca 1 0.02 0.39 1.44
112 INT111760 Dio1 Positive_regulation of Binding of Cpe 1 0.04 0.34 1.44
113 INT150682 Pomc Regulation of Gene_expression of Eif2ak3 1 0.37 0.17 1.44
114 INT128915 PENK Regulation of Gene_expression of OPRM1 1 0.22 0.07 1.43
115 INT111756 Dio1 Positive_regulation of Cpe 1 0.04 0.34 1.42
116 INT202910 Uchl1 Positive_regulation of Gene_expression of Tacr1 1 0.05 1.65 1.42
117 INT202912 Uchl1 Positive_regulation of Gene_expression of Ntrk2 1 0.08 1.64 1.42
118 INT29554 Ebp Positive_regulation of LH 2 0.40 0.12 1.41
119 INT96796 ITIH4 Regulation of Gene_expression of OPRM1 2 0.20 0.89 1.41
120 INT298458 Binding of Calcrl and Adarb1 1 0.00 0.23 1.41
121 INT128914 COMT Regulation of OPRM1 1 0.39 0.07 1.39
122 INT116827 Binding of UCHL1 and TRPV1 1 0.41 0.88 1.39
123 INT29599 Binding of Cyp21a1 and Adarb1 1 0.01 0 1.38
124 INT158762 Binding of Vwf and Mthfr 1 0.05 1.85 1.37
125 INT279165 Calca Regulation of Gene_expression of Fdft1 1 0.02 0.41 1.37
126 INT51203 Binding of OPRK1 and OPRM1 2 0.29 0.3 1.36
127 INT160590 CSF2 Positive_regulation of Gene_expression of OPRM1 1 0.16 0.54 1.35
128 INT158079 Binding of Esr1 and Gper 1 0.31 0.97 1.35
129 INT160586 IL6 Positive_regulation of Gene_expression of OPRM1 1 0.14 0.54 1.35
130 INT160588 TNF Positive_regulation of Gene_expression of OPRM1 1 0.20 0.54 1.35
131 INT160587 IFNG Positive_regulation of Gene_expression of OPRM1 1 0.18 0.54 1.35
132 INT160585 IL18 Positive_regulation of Gene_expression of OPRM1 1 0.09 0.54 1.35
133 INT160589 IL4 Positive_regulation of Gene_expression of OPRM1 1 0.13 0.54 1.35
134 INT261463 Binding of Drd1a and Sftpd 1 0.12 0.13 1.35
135 INT122659 Binding of CACNA1A and SAR1B 1 0.06 1.38 1.35
136 INT145930 ecs Positive_regulation of Gene_expression of Bcl2 1 0.01 2.06 1.34
137 INT314213 Mapk14 Positive_regulation of Agtrap 1 0.04 1.15 1.34
138 INT51200 Binding of OPRM1 and PENK 2 0.17 0.23 1.31
139 INT90221 Binding of CYP2D6 and Cyp1a2 1 0.03 0.09 1.31
140 INT132412 Negative_regulation of Ngf Negative_regulation of Ptgs1 1 0.01 0.81 1.31
141 INT314211 Ngf Positive_regulation of Gene_expression of Agtrap 1 0.04 1.15 1.3
142 INT201942 DPP4 Negative_regulation of CXCL10 1 0.33 0.9 1.3
143 INT148778 Binding of Usf1 and Rtn1 1 0.40 0.85 1.3
144 INT169297 TRPV1 Positive_regulation of EGFR 1 0.64 0.37 1.3
145 INT138211 Mzb1 Regulation of Sst 1 0.05 0.41 1.29
146 INT138212 Mzb1 Regulation of Localization of Sst 1 0.12 0.41 1.29
147 INT138213 Mzb1 Regulation of Localization of Tac1 1 0.01 0.41 1.29
148 INT138210 Mzb1 Regulation of Calca 1 0.25 0.41 1.29
149 INT73597 Positive_regulation of BAX Positive_regulation of Casp1 1 0.06 0.69 1.28
150 INT138214 Mzb1 Regulation of Tac1 1 0.01 0.41 1.28
151 INT169289 CNR1 Positive_regulation of EGFR 1 0.62 0.36 1.28
152 INT195929 Binding of OPRM1 and Prkaca 1 0.02 0.33 1.27
153 INT105295 WAS Regulation of PTGS1 1 0.02 0.13 1.27
154 INT86518 Ass1 Positive_regulation of Hmox2 1 0.03 0.08 1.27
155 INT73598 BAX Positive_regulation of Casp1 1 0.06 0.63 1.27
156 INT64077 Trpv1 Positive_regulation of Kcnma1 1 0.00 0.37 1.27
157 INT42580 CAT Negative_regulation of POMC 1 0.20 0.42 1.26
158 INT114635 Hmox2 Positive_regulation of Gene_expression of Fos 1 0.47 0.88 1.26
159 INT110542 SIGMAR1 Regulation of OPRM1 1 0.04 0.33 1.25
160 INT110543 SIGMAR1 Regulation of Gene_expression of OPRM1 1 0.04 0.33 1.25
161 INT352269 Binding of Jund and Adora1 1 0.15 1.2 1.25
162 INT317569 Prkca Positive_regulation of Phosphorylation of Src 1 0.11 0 1.25
163 INT314212 Mapk14 Positive_regulation of Gene_expression of Agtrap 1 0.06 1.09 1.24
164 INT167278 Binding of OPRM1 and REST 1 0.08 0.94 1.24
165 INT158545 Binding of Trpc3 and Jph2 1 0.55 0 1.24
166 INT136255 Tff3 Regulation of GRIA1 1 0.00 0.18 1.24
167 INT172141 IL10 Negative_regulation of Gene_expression of HLA-DRA 2 0.14 0.89 1.23
168 INT136258 Creb1 Regulation of GRIA1 1 0.26 0.18 1.23
169 INT136249 Drd1a Positive_regulation of Phosphorylation of Tff3 1 0.01 0.18 1.23
170 INT310066 Negative_regulation of Pain1 Positive_regulation of Faah 1 0.03 1.32 1.23
171 INT131195 Creb1 Positive_regulation of Positive_regulation of Drd1a 2 0.27 0.61 1.22
172 INT103031 Calca Positive_regulation of Ptgs1 2 0.46 0.98 1.22
173 INT310068 Pain1 Positive_regulation of Faah 1 0.03 1.3 1.22
174 INT77806 Edn1 Regulation of Gene_expression of Ptgs2 1 0.29 1.24 1.22
175 INT59707 PSENEN Regulation of Negative_regulation of YY1 1 0.12 0.07 1.21
176 INT301166 LRP2 Regulation of TRD@ 1 0.12 1.93 1.21
177 INT281373 Tcf21 Regulation of Fig4 1 0.03 0.67 1.2
178 INT83428 Binding of ADIPOQ and FRTS 3 0.18 2.02 1.19
179 INT281077 Binding of Gria2 and Gria3 2 0.24 0.35 1.19
180 INT113242 TNF Regulation of Transcription of OPRM1 2 0.45 1.53 1.19
181 INT281383 FSCN1 Positive_regulation of Fig4 1 0.02 0.44 1.19
182 INT184402 Binding of HLA-DRB4 and HLA-E 1 0.00 3.1 1.19
183 INT49955 OPRM1 Positive_regulation of ADCY1 1 0.21 0.31 1.19
184 INT57824 Binding of Trim13 and Slc25a2 1 0.01 0.08 1.19
185 INT321475 Slc6a2 Positive_regulation of Ubqln1 1 0.00 0.38 1.19
186 INT203168 PTGER2 Negative_regulation of Gene_expression of ALOX5AP 1 0.03 2.4 1.18
187 INT120205 Binding of App and Ern1 1 0.05 2.55 1.18
188 INT20929 Binding of Trim13 and Vas1 1 0.10 0 1.18
189 INT150835 Gper Positive_regulation of Localization of Prkce 1 0.15 0.62 1.18
190 INT49956 OPRM1 Positive_regulation of SGCG 1 0.53 0.3 1.18
191 INT169082 Binding of GRIA1 and MOCOS 2 0.07 1.23 1.17
192 INT57823 Binding of Trim13 and Atxn2l 1 0.00 0.08 1.17
193 INT111221 MMEL1 Negative_regulation of HMOX1 1 0.01 1 1.16
194 INT195117 Ptgs2 Positive_regulation of Gene_expression of Il6 1 0.10 3.26 1.16
195 INT215648 Binding of Adora1 and Gabrd 1 0.03 0.06 1.16
196 INT117082 TNS3 Regulation of Ssr1 1 0.05 0 1.16
197 INT76256 Binding of Slc6a3 and Sigmar1 1 0.20 0 1.16
198 INT299985 BDKRB2 Regulation of Gene_expression of BDKRB1 1 0.21 0.75 1.16
199 INT137144 ITIH4 Regulation of OPRM1 1 0.20 1.13 1.16
200 INT25026 PLOD1 Regulation of FSHR 4 0.19 0.38 1.15

Single Events

The table below shows the top 100 pain related interactions that have been reported for endoplasmic reticulum. They are ordered first by their pain relevance and then by number of times they were reported in endoplasmic reticulum. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT6580 Negative_regulation of Ptgs1 929 0.59 381.53 376.26
2 INT34869 Negative_regulation of PTGS2 778 0.59 366.76 319.85
3 INT11624 Gene_expression of OPRM1 445 0.78 72.36 294.36
4 INT2391 Negative_regulation of PTGS1 501 0.59 207.62 205.6
5 INT4768 Positive_regulation of OPRM1 212 0.70 31.09 164.28
6 INT4658 Binding of OPRM1 188 0.48 25.96 136.24
7 INT64161 Positive_regulation of Prkca 213 0.70 85.06 129.91
8 INT50674 Gene_expression of PTGS2 459 0.78 253.33 118.51
9 INT170025 Gene_expression of Fig4 588 0.67 183.27 113.32
10 INT8413 Gene_expression of Ptgs1 248 0.78 110.17 108.58
11 INT940 Negative_regulation of Ptgs1 219 0.59 104.34 95.97
12 INT1639 Negative_regulation of OPRM1 107 0.59 13.86 90.37
13 INT64158 Negative_regulation of Prkca 121 0.59 29.8 88.66
14 INT73340 Negative_regulation of Faah 134 0.59 38.67 85.03
15 INT7528 Regulation of OPRM1 100 0.62 20.63 80.57
16 INT920 Localization of PLOD1 223 0.81 42.25 78.7
17 INT29708 Gene_expression of Gria1 177 0.78 56.36 77.37
18 INT15913 Negative_regulation of CYP2D6 174 0.59 22.45 70.91
19 INT171145 Positive_regulation of Fig4 274 0.59 93.55 69.81
20 INT15613 Negative_regulation of Ptgs2 160 0.59 71.08 65.08
21 INT1169 Negative_regulation of Bche 322 0.59 149.22 61.27
22 INT39153 Positive_regulation of PTGS2 182 0.70 96.16 60.6
23 INT9196 Gene_expression of PTGS1 215 0.77 96.99 60.5
24 INT64159 Gene_expression of Prkca 90 0.78 34.65 55.97
25 INT52692 Gene_expression of Ptgs2 160 0.78 85.06 55.73
26 INT82650 Gene_expression of Bcl2 312 0.78 211.71 55.03
27 INT8071 Positive_regulation of Gria1 102 0.70 26.61 53.37
28 INT5759 Positive_regulation of Ptgs1 127 0.69 53.45 53.04
29 INT52611 Negative_regulation of Ptgs2 142 0.59 66.31 52.71
30 INT69484 Positive_regulation of Gene_expression of OPRM1 75 0.70 12.86 52.27
31 INT5858 Positive_regulation of Drd1a 66 0.69 4.51 51.73
32 INT50405 Negative_regulation of CYP3A4 238 0.59 53.65 51.51
33 INT53083 Gene_expression of Ptgs2 153 0.78 90.04 50.39
34 INT7093 Negative_regulation of CYP2B6 146 0.58 37.3 48.39
35 INT170646 Negative_regulation of Fig4 213 0.37 81.29 46.92
36 INT48718 Positive_regulation of PRKCA 109 0.69 36.16 46.49
37 INT16364 Gene_expression of HLA-DRA 234 0.78 118.81 45.01
38 INT1564 Localization of OPRM1 41 0.80 8.03 44.67
39 INT8465 Regulation of Ptgs1 100 0.57 36.03 44.41
40 INT3933 Positive_regulation of PLOD1 128 0.70 30.76 42.03
41 INT57442 Phosphorylation of Prkca 98 0.70 31.58 41.04
42 INT55135 Positive_regulation of Gene_expression of PTGS2 137 0.70 80.32 38.46
43 INT77307 Gene_expression of Bcl2 399 0.77 319.77 38
44 INT56870 Gene_expression of CYP2D6 87 0.78 8.83 37.53
45 INT95646 Negative_regulation of Faah 63 0.59 25.61 36.78
46 INT77407 Regulation of Gene_expression of OPRM1 51 0.62 12.58 35.75
47 INT10796 Gene_expression of CYP2B6 131 0.77 30.14 35.27
48 INT4403 Binding of CYP2B6 113 0.48 21.17 33.83
49 INT40160 Positive_regulation of Adora1 74 0.70 26.36 33.03
50 INT913 Regulation of Localization of PLOD1 71 0.62 8.64 32.72
51 INT20307 Positive_regulation of Cyp2e1 70 0.70 23.59 32.49
52 INT73982 Gene_expression of Hmox1 141 0.78 119.43 32.17
53 INT124860 Gene_expression of Bace1 330 0.78 157.11 31.65
54 INT114173 Phosphorylation of Gria1 27 0.82 33.73 31.24
55 INT49001 Regulation of Gria1 51 0.56 18.28 31.22
56 INT86780 Positive_regulation of Hmox1 145 0.70 117.09 31.18
57 INT10797 Binding of CYP2D6 86 0.48 15.09 31.16
58 INT64164 Regulation of Prkca 34 0.62 10.44 30.99
59 INT49110 Regulation of Grip2 46 0.61 13.57 30.87
60 INT65960 Gene_expression of BCL2 352 0.78 312.03 30.73
61 INT7975 Regulation of PLOD1 97 0.62 20.9 30.51
62 INT69483 Transcription of OPRM1 45 0.72 7.31 30.22
63 INT52690 Positive_regulation of Ptgs2 65 0.68 39.51 30.02
64 INT7664 Negative_regulation of Grip2 68 0.49 10.11 29.93
65 INT64918 Gene_expression of Gria2 108 0.74 29.95 29.67
66 INT72252 Gene_expression of Kcnma1 63 0.64 20.47 29.56
67 INT12751 Gene_expression of Pigm 91 0.58 22.42 29.2
68 INT651 Positive_regulation of PTGS1 93 0.69 37.27 29.18
69 INT49431 Phosphorylation of OPRM1 31 0.82 2.2 29.09
70 INT2389 Regulation of PTGS1 86 0.61 31.23 28.95
71 INT28361 Gene_expression of TP53 443 0.78 384.86 28.8
72 INT56525 Gene_expression of Gria2 74 0.75 23.15 28.6
73 INT52712 Negative_regulation of PRKCA 64 0.57 23.11 28.43
74 INT22211 Positive_regulation of CYP3A4 110 0.70 22 28.27
75 INT177581 Regulation of Fig4 113 0.41 39.26 27.75
76 INT12129 Gene_expression of CYP3A4 107 0.78 23.11 27.6
77 INT5923 Negative_regulation of Rtn4 50 0.36 24.19 27.2
78 INT1638 Negative_regulation of PLOD1 92 0.59 21.69 26.61
79 INT56524 Gene_expression of Grip2 67 0.74 14.77 26.23
80 INT48832 Positive_regulation of Grip2 48 0.69 12.13 25.99
81 INT50490 Regulation of PTGS2 80 0.48 39.51 25.85
82 INT6115 Positive_regulation of Pigm 82 0.64 16.96 25.73
83 INT11159 Gene_expression of EGFR 698 0.78 548.93 25.69
84 INT2040 Positive_regulation of CYP2B6 95 0.69 34.3 25.6
85 INT9886 Gene_expression of Ptgs1 92 0.77 40.66 25.31
86 INT100423 Gene_expression of Bax 141 0.75 98.43 24.48
87 INT13334 Gene_expression of Drd1a 43 0.62 7.73 24.43
88 INT64076 Positive_regulation of Kcnma1 47 0.40 11.52 24.19
89 INT67585 Gene_expression of UGT2B7 52 0.78 2.33 24.13
90 INT101225 Positive_regulation of Gria2 62 0.64 28.1 23.93
91 INT13838 Positive_regulation of Drd1a 48 0.70 9.83 23.42
92 INT917 Positive_regulation of Localization of PLOD1 51 0.69 8.53 22.87
93 INT16721 Negative_regulation of Cat 56 0.59 44.44 22.84
94 INT76249 Gene_expression of Gria1 67 0.75 15.07 22.78
95 INT102112 Gene_expression of Prnp 440 0.78 209.32 22.5
96 INT8640 Positive_regulation of HSD11B1 332 0.67 377.84 22.36
97 INT21503 Binding of Ptgs1 45 0.48 15.6 22.29
98 INT71047 Gene_expression of CYP19A1 122 0.78 68.78 22.21
99 INT39914 Negative_regulation of Cyp1a2 44 0.58 10.04 22
100 INT7573 Positive_regulation of Nr3c2 38 0.67 20 21.84
101 INT47859 Negative_regulation of Cyp2e1 41 0.59 16.92 21.72
102 INT49623 Negative_regulation of Gria1 39 0.59 12.4 21.59
103 INT52693 Positive_regulation of Gene_expression of Ptgs2 57 0.70 25.51 21.18
104 INT117527 Binding of Prkca 25 0.48 6.43 21.05
105 INT129987 Phosphorylation of Gria1 63 0.80 20.65 21.02
106 INT11161 Gene_expression of HLA-DRB1 121 0.78 75.33 20.96
107 INT73593 Gene_expression of BAX 173 0.76 147.81 20.94
108 INT171820 Localization of Fig4 144 0.65 27.38 20.88
109 INT12951 Negative_regulation of Cat 126 0.57 64.39 20.61
110 INT17848 Binding of PTGS2 70 0.46 32.1 20.6
111 INT45840 Positive_regulation of Gene_expression of Ptgs1 35 0.50 16.07 20.49
112 INT79805 Phosphorylation of PRKCA 57 0.81 23.33 20.41
113 INT8765 Positive_regulation of Cyp3a23/3a1 63 0.67 22.28 20.39
114 INT20305 Gene_expression of Cyp2e1 53 0.78 19.75 19.54
115 INT7680 Regulation of Drd1a 27 0.45 4.52 18.86
116 INT56239 Positive_regulation of Rtn4 20 0.26 14.05 18.8
117 INT113399 Positive_regulation of Pla2g4a 36 0.67 33.83 18.78
118 INT636 Binding of MRAP 54 0.48 40.36 18.77
119 INT3060 Negative_regulation of Bche 94 0.59 46.75 18.51
120 INT93734 Positive_regulation of Gene_expression of Bcl2 76 0.70 61.95 18.46
121 INT68347 Negative_regulation of Cyp2d4 34 0.58 7.62 18.35
122 INT30197 Positive_regulation of Ubqln1 26 0.08 2.07 18.28
123 INT14724 Negative_regulation of CYP19A1 233 0.59 96.56 18.26
124 INT187513 Positive_regulation of Pla2g4a 5 0.62 34.09 18.22
125 INT9900 Positive_regulation of Vwf 80 0.69 51.85 18.13
126 INT9246 Positive_regulation of Cat 113 0.70 52.73 18.04
127 INT1642 Negative_regulation of Localization of PLOD1 40 0.58 10.67 17.95
128 INT14111 Positive_regulation of Cyp2c22 41 0.67 7.24 17.88
129 INT5922 Gene_expression of Rtn4 27 0.48 12.7 17.86
130 INT29709 Positive_regulation of Gene_expression of Gria1 36 0.69 9.43 17.83
131 INT50403 Negative_regulation of CYP2C19 55 0.59 8.97 17.79
132 INT80223 Positive_regulation of Hmox1 128 0.68 77.71 17.64
133 INT84464 Gene_expression of DPP4 101 0.78 56.15 17.53
134 INT51779 Gene_expression of Drd1a 46 0.66 11.18 17.51
135 INT101140 Negative_regulation of Tap1 7 0.50 9.08 17.46
136 INT50579 Binding of CYP3A4 84 0.48 17.52 17.45
137 INT86673 Positive_regulation of Bcl2 77 0.70 57.74 17.37
138 INT50404 Negative_regulation of CYP1A2 49 0.59 8.61 17.35
139 INT22068 Binding of CALCRL 53 0.41 6.14 17.32
140 INT76406 Gene_expression of Hmox1 140 0.78 85.86 17.15
141 INT195831 Phosphorylation of Pla2g4a 15 0.74 34.43 17.14
142 INT7020 Negative_regulation of Drd1a 25 0.57 1.84 17.1
143 INT95930 Negative_regulation of Gria2 63 0.56 18.37 17.04
144 INT48690 Localization of Grip2 33 0.61 6.13 16.81
145 INT32753 Positive_regulation of Positive_regulation of OPRM1 19 0.62 3.3 16.73
146 INT65856 Positive_regulation of TP53 138 0.67 112.65 16.71
147 INT170033 Positive_regulation of Gene_expression of Fig4 59 0.43 20.99 16.69
148 INT93361 Gene_expression of Trp53 208 0.78 175.35 16.65
149 INT117500 Gene_expression of Adipoq 90 0.74 67.79 16.58
150 INT1020 Negative_regulation of BCHE 109 0.59 44.86 16.4
151 INT49263 Binding of Grip2 31 0.41 9.86 16.38
152 INT9197 Binding of PTGS1 44 0.48 18.48 16.26
153 INT62861 Regulation of Gria2 45 0.60 13.35 16.07
154 INT80972 Gene_expression of Tp53 104 0.78 102.74 16.02
155 INT59987 Gene_expression of BDKRB1 25 0.77 11.95 15.93
156 INT50618 Gene_expression of Dio1 48 0.74 17.37 15.91
157 INT111073 Gene_expression of Psen1 167 0.76 78.65 15.83
158 INT131296 Positive_regulation of Bace1 208 0.70 170.1 15.79
159 INT79458 Localization of Prkca 30 0.81 11.13 15.78
160 INT12950 Gene_expression of Cat 85 0.75 35.94 15.76
161 INT20336 Positive_regulation of CYP2E1 48 0.70 19.26 15.66
162 INT5859 Positive_regulation of Positive_regulation of Drd1a 20 0.55 2.05 15.61
163 INT7970 Gene_expression of PLOD1 120 0.71 44.42 15.54
164 INT12837 Binding of SIGMAR1 57 0.48 5.31 15.49
165 INT15102 Gene_expression of Trim13 18 0.67 0.43 15.49
166 INT61172 Gene_expression of PRKCA 34 0.77 8.89 15.47
167 INT42810 Gene_expression of CALCRL 53 0.77 10.87 15.42
168 INT59929 Negative_regulation of CYP2C9 60 0.59 16.33 15.39
169 INT195414 Gene_expression of ALOX5AP 65 0.72 31.22 15.25
170 INT143276 Phosphorylation of Gria2 42 0.80 16.07 15.2
171 INT32706 Gene_expression of Cyp3a23/3a1 51 0.65 19.48 15.06
172 INT25872 Positive_regulation of Adora1 19 0.69 4.9 15.01
173 INT114172 Positive_regulation of Phosphorylation of Gria1 8 0.63 15.73 14.99
174 INT114510 Positive_regulation of Gria2 36 0.57 14.91 14.85
175 INT109031 Positive_regulation of Eif2ak3 44 0.69 21.11 14.72
176 INT9904 Gene_expression of CYP2E1 64 0.78 13.11 14.65
177 INT26975 Gene_expression of Adipoq 113 0.75 106.71 14.46
178 INT52696 Positive_regulation of Ptgs2 48 0.70 27.65 14.44
179 INT53080 Positive_regulation of Ptgs1 42 0.42 23.58 14.37
180 INT109511 Gene_expression of Bax 133 0.78 113.22 14.36
181 INT61864 Regulation of Gene_expression of Gria1 24 0.62 13.27 14.3
182 INT19408 Negative_regulation of Cyp2c22 37 0.59 6.23 14.22
183 INT109034 Gene_expression of Eif2ak3 37 0.77 17.11 14.19
184 INT80228 Positive_regulation of Gene_expression of Hmox1 68 0.70 62.88 14.01
185 INT1873 Gene_expression of MRAP 51 0.76 31.75 13.92
186 INT91544 Gene_expression of CHI3L1 60 0.75 77.72 13.9
187 INT7997 Gene_expression of Ltc4s 51 0.76 34.28 13.8
188 INT6645 Positive_regulation of BDKRB1 14 0.66 12.17 13.79
189 INT53070 Regulation of Rtn4 15 0.22 9.35 13.77
190 INT49089 Gene_expression of Rab38 22 0.45 6.79 13.76
191 INT76863 Negative_regulation of Gene_expression of OPRM1 21 0.57 6.56 13.69
192 INT56651 Binding of HLA-DRB1 58 0.48 52.25 13.68
193 INT52714 Regulation of PRKCA 28 0.61 7.73 13.66
194 INT80883 Positive_regulation of Phosphorylation of OPRM1 13 0.69 1.03 13.65
195 INT12321 Binding of Nr3c2 19 0.46 5.44 13.46
196 INT64563 Gene_expression of UGT1A1 27 0.75 3.31 13.43
197 INT53747 Positive_regulation of Cyp2e1 34 0.70 29.03 13.39
198 INT18191 Negative_regulation of Cyp3a23/3a1 48 0.57 10.21 13.38
199 INT76469 Positive_regulation of Gene_expression of Prkca 18 0.46 7.9 13.36
200 INT49538 Binding of Gria1 22 0.47 2.66 13.35
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