GO:0005876

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Name spindle microtubule
Categary Component
Go Slim No
Go Link GO:0005876
Unique Molecular Interactions 137
Total Molecular Interactions 243
Total Single Events 1101
Pain Genes Associated 19

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for spindle microtubule. They are ordered first by their pain relevance and then by number of times they were reported for spindle microtubule. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT97013 Negative_regulation of Binding of CALM3 and OPRM1 1 0.40 0 1.05
2 INT97011 Binding of CALM3 and OPRM1 1 0.35 0 1.05
3 INT92404 PSRC1 Regulation of CDKN1A 1 0.33 0.66 0.89
4 INT309735 Binding of CALM3 and TRPV4 1 0.14 0 0.75
5 INT92403 PSRC1 Regulation of Positive_regulation of CDKN1A 1 0.33 0.45 0.6
6 INT55262 Pigt Regulation of Calm2 1 0.07 0 0.47
7 INT55260 Cck Positive_regulation of Positive_regulation of Calm2 1 0.62 0 0.45
8 INT254460 Binding of Calm2 and Ca2 5 0.03 0.48 0.43
9 INT261058 Binding of CALM3 and CHR 1 0.04 0.14 0.38
10 INT265145 Calm2 Negative_regulation of Phosphorylation of Adrbk1 1 0.05 0.07 0.35
11 INT265146 Calm2 Negative_regulation of Phosphorylation of Prkcg 1 0.04 0.07 0.35
12 INT279705 CALM3 Regulation of TRPV4 2 0.08 0 0.33
13 INT265139 Binding of Calm2 and Cib1 1 0.00 0 0.33
14 INT170727 Binding of Grm5 and Calm2 1 0.01 0.13 0.28
15 INT261056 Binding of CALM3 and PLA2G6 1 0.09 0 0.27
16 INT261045 Negative_regulation of Binding of CALM3 and PLA2G6 1 0.10 0 0.27
17 INT182325 TP53 Negative_regulation of Transcription of Birc5 1 0.01 1.34 0.26
18 INT261052 CALM3 Regulation of VIP 1 0.00 0.06 0.25
19 INT294487 Binding of Calm1 and Tcm 1 0.00 0.81 0.23
20 INT309729 CALM3 Regulation of TRPV1 1 0.04 0 0.22
21 INT7332 CALM3 Positive_regulation of ADCY1 1 0.46 0.13 0.21
22 INT269994 Binding of Nfkb2 and Tpx2 1 0.04 0.51 0.21
23 INT269995 Positive_regulation of Binding of Nfkb2 and Tpx2 1 0.05 0.51 0.21
24 INT182326 LBR Positive_regulation of Gene_expression of Birc5 1 0.00 0.46 0.17
25 INT261055 Negative_regulation of Binding of CALM3 and CHR 1 0.04 0 0.14
26 INT309743 Binding of CA2 and CALM3 1 0.04 0 0.13
27 INT252032 Binding of Calm1 and DXIum1 1 0.02 0.48 0.13
28 INT309747 CALM3 Regulation of TRPV5 1 0.03 0 0.13
29 INT309742 CALM3 Regulation of TRPV3 1 0.04 0 0.13
30 INT311111 Binding of Pcp4 and Calm2 1 0.11 0.57 0.13
31 INT309733 CALM3 Regulation of TRPV6 1 0.01 0 0.13
32 INT175196 Binding of NCOR1 and NUP62 1 0.02 0.84 0.12
33 INT309725 Gene_expression of CALM3 Negative_regulation of Positive_regulation of TRPC6 1 0.07 0 0.1
34 INT254456 Negative_regulation of Binding of Calm2 and Ca2 1 0.03 0 0.1
35 INT306274 Binding of CCNB1 and CDK1 1 0.19 0.13 0.09
36 INT309738 CALM3 Positive_regulation of CA2 1 0.04 0 0.08
37 INT320267 CCNA2 Positive_regulation of CDK1 1 0.12 1.08 0.08
38 INT254459 Ca2 Positive_regulation of Calm2 1 0.03 0 0.08
39 INT309737 Binding of CALM3 and Positive_regulation of CA2 1 0.04 0 0.08
40 INT302290 Birc5 Regulation of BAK1 1 0.21 1.22 0.07
41 INT302289 Negative_regulation of Birc5 Regulation of BAK1 1 0.20 1.22 0.07
42 INT277615 Positive_regulation of Binding of ZNF238 and Hdac3 1 0.38 0.06 0.07
43 INT277614 Binding of ZNF238 and Hdac3 1 0.29 0.06 0.07
44 INT275105 CALM3 Positive_regulation of Prkcg 1 0.00 0 0.06
45 INT309748 CALM3 Regulation of CA2 1 0.02 0 0.06
46 INT309732 CALM3 Positive_regulation of Gene_expression of TRPV4 1 0.14 0 0.06
47 INT309752 CALM3 Positive_regulation of Gene_expression of CA2 1 0.04 0 0.06
48 INT298806 Binding of Hdac3 and Rb1 1 0.02 0.77 0.05
49 INT262781 Birc5 Regulation of TEP1 1 0.00 0.49 0.05
50 INT262780 Birc5 Regulation of CD163L1 1 0.00 0.49 0.05
51 INT218953 Esyt1 Negative_regulation of Ncor1 1 0.00 0.1 0.05
52 INT332895 Binding of Ppara and Ncor1 1 0.31 0.15 0.05
53 INT309730 Binding of CALM3 and TYRP1 1 0.01 0 0.05
54 INT261057 Binding of CALM3 and CHGA 1 0.04 0.14 0.04
55 INT213607 Binding of CSNK1D and CLOCK 1 0.27 0.65 0.04
56 INT274715 TBL1XR1 Positive_regulation of TIMP1 1 0.00 0.26 0.04
57 INT261042 Binding of CALM3 and VIP 1 0.00 0.14 0.04
58 INT94159 Positive_regulation of CDK1 Negative_regulation of RB1 1 0.45 0.93 0.03
59 INT94158 CDK1 Negative_regulation of RB1 1 0.41 0.92 0.03
60 INT170725 Binding of Calm2 and Pla2g3 1 0.00 0 0.03
61 INT283346 Binding of Srr and Kif3a 1 0.17 0 0
62 INT292505 PTK2 Regulation of Birc5 1 0.29 0.76 0
63 INT292515 LAMB2 Positive_regulation of Birc5 1 0.01 0.7 0
64 INT332881 Negative_regulation of Binding of Hdac3 and Ncor1 1 0.28 0.18 0
65 INT236246 Binding of CD8A and Birc5 1 0.04 1.34 0
66 INT292512 AKT1 Regulation of Birc5 1 0.08 0.76 0
67 INT268316 Cdk1 Positive_regulation of Mcm3 1 0.28 0.25 0
68 INT309745 Negative_regulation of Binding of CALM3 and TRPV4 1 0.12 0 0
69 INT284920 Binding of HDAC1 and NCOR1 1 0.03 0.13 0
70 INT252031 DXIum1 Positive_regulation of Calm1 1 0.02 0 0
71 INT271996 Binding of Plk1 and Tsc1 1 0.09 0.32 0
72 INT170723 Binding of Calm2 and Siah1a 1 0.24 0 0
73 INT193118 Trp53 Regulation of Gene_expression of Birc5 1 0.19 0.86 0
74 INT182399 E2F2 Regulation of CDK1 1 0.00 0.09 0
75 INT237980 CCND3 Regulation of Gene_expression of Birc5 1 0.06 0.96 0
76 INT268318 Cdk1 Positive_regulation of Orc2 1 0.29 0.25 0
77 INT274716 TBL1XR1 Positive_regulation of Gene_expression of MMP1 1 0.02 0.45 0
78 INT309746 CALM3 Positive_regulation of CAMK2G 1 0.02 0 0
79 INT339977 Positive_regulation of Binding of HDAC3 and HDAC7 1 0.23 0.52 0
80 INT236241 Binding of Birc5 and Ifna 1 0.05 0.31 0
81 INT187575 TP53 Regulation of Gene_expression of Birc5 1 0.05 1.1 0
82 INT182406 NFYA Regulation of CDK1 1 0.00 0.09 0
83 INT250718 PIK3CB Regulation of Gene_expression of Birc5 1 0.23 0.91 0
84 INT309734 Binding of CALM3 and RPLP2 1 0.01 0 0
85 INT293979 Binding of CSNK1D and CSNK1E 1 0.21 0.18 0
86 INT235166 Binding of Hdac3 and Atxn1 1 0.02 0.28 0
87 INT268319 Cdk1 Positive_regulation of Cdc20 1 0.32 0.25 0
88 INT332894 Binding of Ahrr and Hdac3 1 0.01 0.08 0
89 INT170726 Negative_regulation of Binding of Grm5 and Calm2 1 0.01 0 0
90 INT268317 Cdk1 Positive_regulation of Mcm7 1 0.33 0.25 0
91 INT332896 Binding of Hdac3 and Ncor1 1 0.31 1.38 0
92 INT332882 Ncor1 Negative_regulation of Gene_expression of Arntl 1 0.31 0.17 0
93 INT170720 Negative_regulation of Binding of Calm2 and Pla2g3 1 0.00 0 0
94 INT339978 Binding of HDAC3 and HDAC7 1 0.17 1.04 0
95 INT332878 Hdac3 Negative_regulation of Gene_expression of Arntl 1 0.42 0.17 0
96 INT187574 Binding of TP53 and Birc5 1 0.04 1.27 0
97 INT271997 Binding of Cdk1 and Plk1 1 0.03 0.3 0
98 INT187576 BAX Regulation of Gene_expression of Birc5 1 0.06 1.1 0
99 INT249828 Foxm1 Positive_regulation of Transcription of BIRC5 1 0.56 0.12 0
100 INT235167 Binding of Hdac3 and Ncor2 1 0.01 0.28 0
101 INT144042 STAT3 Regulation of Birc5 1 0.47 0.06 0
102 INT332892 Ncor1 Positive_regulation of Hdac3 1 0.45 0.18 0
103 INT332879 Negative_regulation of Ncor1 Positive_regulation of Hdac3 1 0.28 0.18 0
104 INT268315 Cdk1 Positive_regulation of Mcm5 1 0.33 0.25 0
105 INT309753 Binding of CALM3 and GOPC 1 0.04 0 0
106 INT309741 Binding of C2 and CALM3 1 0.03 0 0
107 INT249822 Foxm1 Positive_regulation of Transcription of Plk1 1 0.50 0.12 0
108 INT293980 Negative_regulation of Binding of CSNK1D and CSNK1E 1 0.24 0.18 0
109 INT271998 Cdk1 Positive_regulation of Phosphorylation of Tsc1 1 0.17 0.3 0
110 INT193119 Trp53 Regulation of Birc5 1 0.19 0.55 0
111 INT292492 Mlph Regulation of Gene_expression of Birc5 1 0.04 1.11 0
112 INT237979 PPARA Negative_regulation of Birc5 1 0.49 1.26 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for spindle microtubule. They are ordered first by their pain relevance and then by number of times they were reported in spindle microtubule. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT116465 Gene_expression of Birc5 241 0.78 192.31 15.32
2 INT97018 Binding of CALM3 7 0.43 0.13 5.82
3 INT116464 Negative_regulation of Birc5 53 0.59 45.4 4.91
4 INT29326 Gene_expression of Calm1 17 0.67 3.71 4.53
5 INT182311 Positive_regulation of Birc5 26 0.67 25.32 4.08
6 INT55259 Negative_regulation of Calm2 9 0.49 1.87 3.4
7 INT136651 Binding of Calm2 30 0.42 1.09 3.11
8 INT116463 Negative_regulation of Gene_expression of Birc5 40 0.59 33.99 2.74
9 INT182312 Positive_regulation of Gene_expression of Birc5 26 0.69 25.3 2.32
10 INT182318 Regulation of Birc5 25 0.60 23.58 2.29
11 INT37899 Positive_regulation of Calm2 10 0.58 0.53 2.27
12 INT121869 Negative_regulation of Calm1 2 0.57 0 1.83
13 INT7333 Localization of CALM3 4 0.72 0.4 1.55
14 INT37900 Regulation of Calm2 9 0.36 0.52 1.4
15 INT136650 Gene_expression of Calm2 18 0.51 1.57 1.39
16 INT100275 Gene_expression of TBL1XR1 19 0.25 6.99 1.33
17 INT97017 Regulation of Binding of CALM3 2 0.40 0 1.06
18 INT7338 Negative_regulation of CALM3 5 0.34 0.19 1
19 INT97014 Regulation of CALM3 1 0.55 0 0.97
20 INT97020 Negative_regulation of Regulation of CALM3 1 0.52 0 0.97
21 INT182313 Regulation of Gene_expression of Birc5 18 0.60 15.34 0.96
22 INT7335 Positive_regulation of CALM3 6 0.36 0.28 0.79
23 INT83375 Gene_expression of CALM3 3 0.58 1.57 0.78
24 INT70423 Binding of HDAC3 1 0.01 0.36 0.75
25 INT258791 Positive_regulation of CDK1 14 0.45 5.73 0.74
26 INT57654 Negative_regulation of Negative_regulation of Calm2 1 0.28 0.16 0.73
27 INT62273 Gene_expression of CDK1 19 0.75 8.43 0.68
28 INT274725 Regulation of TBL1XR1 5 0.11 2.08 0.64
29 INT160948 Negative_regulation of Gene_expression of Calm1 1 0.15 0.99 0.62
30 INT182317 Binding of Birc5 8 0.32 4.63 0.56
31 INT327658 Regulation of Ncor1 1 0.13 0 0.56
32 INT193108 Negative_regulation of Negative_regulation of Birc5 6 0.42 5.25 0.53
33 INT62272 Negative_regulation of CDK1 9 0.57 6.46 0.46
34 INT182315 Positive_regulation of Negative_regulation of Birc5 2 0.45 1.79 0.46
35 INT274724 Positive_regulation of TBL1XR1 5 0.12 2.74 0.45
36 INT170694 Phosphorylation of Calm2 3 0.35 0 0.43
37 INT37898 Positive_regulation of Positive_regulation of Calm2 1 0.40 0 0.41
38 INT216873 Binding of TBL1XR1 3 0.36 4.44 0.4
39 INT127451 Positive_regulation of Cdk1 1 0.20 0.27 0.4
40 INT271922 Phosphorylation of Cdk1 2 0.44 0.37 0.39
41 INT182314 Transcription of Birc5 4 0.69 2.69 0.37
42 INT182319 Localization of Birc5 6 0.75 5.13 0.34
43 INT63268 Negative_regulation of Ncor1 5 0.32 0.51 0.34
44 INT160947 Regulation of Gene_expression of Calm1 1 0.16 0.5 0.31
45 INT328194 Transcription of Calm2 1 0.04 0 0.3
46 INT252022 Phosphorylation of Calm1 1 0.55 0.55 0.27
47 INT252023 Positive_regulation of Calm1 1 0.44 0.79 0.27
48 INT274742 Localization of TBL1XR1 2 0.24 1.4 0.26
49 INT261086 Positive_regulation of Negative_regulation of CALM3 1 0.16 0 0.26
50 INT100277 Positive_regulation of Gene_expression of TBL1XR1 5 0.19 1.9 0.25
51 INT257786 Localization of NCOR1 1 0.68 0.36 0.24
52 INT137836 Negative_regulation of Binding of Calm2 2 0.51 0 0.23
53 INT188352 Regulation of Calm1 2 0.39 1.6 0.21
54 INT94166 Phosphorylation of CDK1 10 0.79 4.75 0.2
55 INT63271 Regulation of Ncor1 2 0.26 0.8 0.18
56 INT298778 Phosphorylation of Hdac3 1 0.44 0.67 0.17
57 INT193114 Positive_regulation of Positive_regulation of Birc5 1 0.45 0.33 0.17
58 INT63270 Gene_expression of Ncor1 7 0.56 0.65 0.15
59 INT173184 Regulation of CDK1 4 0.30 2.97 0.15
60 INT196421 Negative_regulation of Cdk1 2 0.24 1.17 0.15
61 INT252026 Localization of Calm1 1 0.65 0.55 0.15
62 INT193104 Positive_regulation of Regulation of Birc5 1 0.49 1.61 0.15
63 INT62271 Negative_regulation of Gene_expression of CDK1 2 0.42 1.32 0.14
64 INT265376 Gene_expression of Hdac3 4 0.51 1.8 0.13
65 INT337484 Gene_expression of HDAC3 2 0.37 0.15 0.13
66 INT341562 Negative_regulation of Gene_expression of HDAC3 1 0.23 0.05 0.13
67 INT252021 Binding of Calm1 1 0.42 0.69 0.13
68 INT182316 Positive_regulation of Localization of Birc5 1 0.02 0.99 0.13
69 INT328191 Negative_regulation of Transcription of Calm2 1 0.02 0 0.13
70 INT7334 Positive_regulation of Localization of CALM3 1 0.42 0.17 0.12
71 INT167436 Localization of CDK1 2 0.14 0.41 0.1
72 INT311134 Negative_regulation of Gene_expression of Calm2 1 0.27 0.73 0.1
73 INT331785 Negative_regulation of Gene_expression of Hdac3 1 0.04 0.86 0.1
74 INT309767 Negative_regulation of Gene_expression of CALM3 1 0.13 0 0.1
75 INT186055 Binding of CDK1 3 0.35 1.43 0.09
76 INT193106 Phosphorylation of Birc5 3 0.80 2.13 0.09
77 INT250670 Negative_regulation of Phosphorylation of Birc5 2 0.57 1.17 0.09
78 INT309756 Positive_regulation of Gene_expression of CALM3 1 0.14 0 0.09
79 INT193111 Protein_catabolism of Birc5 2 0.86 1.01 0.08
80 INT238499 Negative_regulation of BIRC5 1 0.23 1.66 0.08
81 INT326819 Negative_regulation of Cdk1 1 0.16 0.39 0.08
82 INT193115 Regulation of Protein_catabolism of Birc5 1 0.44 0.14 0.08
83 INT262749 Negative_regulation of Transcription of Birc5 1 0.02 1.37 0.07
84 INT170713 Positive_regulation of Gene_expression of Calm2 4 0.39 0.36 0.06
85 INT171527 Gene_expression of NCOR1 3 0.51 0.49 0.06
86 INT354439 Positive_regulation of NCOR1 1 0.35 0.15 0.06
87 INT299170 Positive_regulation of Localization of TBL1XR1 1 0.16 0.87 0.06
88 INT170692 Regulation of Gene_expression of Calm2 1 0.25 0.36 0.06
89 INT259746 Phosphorylation of CSNK1D 1 0.03 0.99 0.05
90 INT176238 Gene_expression of Cdk1 5 0.46 0.94 0.04
91 INT265372 Localization of Hdac3 3 0.55 0.6 0.04
92 INT340306 Regulation of Tpx2 1 0.60 0.08 0.04
93 INT210871 Transcription of Ncor1 3 0.50 0 0.03
94 INT94160 Positive_regulation of Phosphorylation of CDK1 2 0.49 0.93 0.03
95 INT265373 Regulation of Hdac3 2 0.17 1.1 0.03
96 INT309477 Positive_regulation of Cdk1 2 0.35 0.21 0.03
97 INT94161 Negative_regulation of Phosphorylation of CDK1 1 0.41 0.93 0.03
98 INT218945 Localization of Ncor1 1 0.32 0.15 0.03
99 INT283314 Localization of Kif3a 1 0.69 0 0.03
100 INT342653 Regulation of Transcription of Ncor1 1 0.31 0 0.03
101 INT237226 Gene_expression of Plk1 3 0.59 0.78 0
102 INT63269 Positive_regulation of Ncor1 2 0.66 0.05 0
103 INT265371 Binding of Hdac3 2 0.27 0.94 0
104 INT254441 Localization of Calm2 2 0.13 0 0
105 INT236691 Regulation of Cdk1 2 0.20 0.46 0
106 INT249774 Positive_regulation of Plk1 2 0.41 0.25 0
107 INT289866 Protein_catabolism of CDK1 1 0.46 0 0
108 INT265375 Negative_regulation of Hdac3 1 0.36 0.78 0
109 INT342659 Positive_regulation of Gene_expression of Ncor1 1 0.35 0 0
110 INT332921 Localization of Ncor1 1 0.04 0.05 0
111 INT249820 Transcription of BIRC5 1 0.67 0.12 0
112 INT249818 Gene_expression of BIRC5 1 0.65 0.12 0
113 INT271928 Binding of Plk1 1 0.07 0.29 0
114 INT283316 Gene_expression of Kif3a 1 0.55 0 0
115 INT210872 Regulation of Gene_expression of Ncor1 1 0.06 0 0
116 INT332370 Regulation of Plk1 1 0.21 0.13 0
117 INT289863 Negative_regulation of Positive_regulation of CDK1 1 0.31 0 0
118 INT289862 Positive_regulation of Gene_expression of CDK1 1 0.26 0 0
119 INT170689 Positive_regulation of Binding of Calm2 1 0.28 0 0
120 INT332346 Phosphorylation of Plk1 1 0.62 0 0
121 INT332828 Gene_expression of Ncor1 1 0.50 0.16 0
122 INT170707 Regulation of Binding of Calm2 1 0.15 0 0
123 INT298111 Positive_regulation of Localization of Calm2 1 0.09 0 0
124 INT261087 Negative_regulation of Positive_regulation of CALM3 1 0.12 0 0
125 INT283315 Positive_regulation of Kif3a 1 0.46 0 0
126 INT294807 Regulation of Negative_regulation of Birc5 1 0.45 1.05 0
127 INT332848 Negative_regulation of Binding of Ncor1 1 0.32 0.36 0
128 INT249761 Transcription of Plk1 1 0.60 0.12 0
129 INT274743 Protein_catabolism of TBL1XR1 1 0.22 0.17 0
130 INT289869 Positive_regulation of Protein_catabolism of CDK1 1 0.26 0 0
131 INT309760 Negative_regulation of Binding of CALM3 1 0.13 0 0
132 INT283328 Binding of Kif3a 1 0.34 0 0
133 INT332842 Binding of Ncor1 1 0.36 0.91 0
134 INT249819 Positive_regulation of Gene_expression of BIRC5 1 0.49 0.12 0
135 INT249770 Positive_regulation of Gene_expression of Plk1 1 0.44 0.12 0
136 INT268284 Gene_expression of Cdk1 1 0.26 0.25 0
137 INT294005 Regulation of Negative_regulation of CSNK1D 1 0.28 0.19 0
138 INT332343 Positive_regulation of Phosphorylation of Plk1 1 0.38 0 0
139 INT249821 Positive_regulation of BIRC5 1 0.45 0.12 0
140 INT250674 Negative_regulation of Positive_regulation of Birc5 1 0.41 1.22 0
141 INT271923 Regulation of Binding of Plk1 1 0.09 0.29 0
142 INT337460 Positive_regulation of Gene_expression of HDAC3 1 0.17 0.1 0
143 INT237227 Negative_regulation of Gene_expression of Plk1 1 0.08 0.54 0
144 INT294021 Negative_regulation of CSNK1D 1 0.26 0.17 0
145 INT274746 Regulation of Gene_expression of TBL1XR1 1 0.02 0.41 0
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