GO:0005887

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Name integral to plasma membrane
Categary Component
Go Slim No
Go Link GO:0005887
Unique Molecular Interactions 7988
Total Molecular Interactions 11728
Total Single Events 96383
Pain Genes Associated 699

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for integral to plasma membrane. They are ordered first by their pain relevance and then by number of times they were reported for integral to plasma membrane. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT69872 Binding of MC1R and POMC 52 0.54 8.87 18.3
2 INT221180 Binding of OPRM1 and Flna 1 0.09 0.22 12.65
3 INT77646 Binding of Ngf and Ntrk1 23 0.40 7.85 9.26
4 INT51205 Binding of OPRK1 and PDYN 7 0.00 2.01 7.8
5 INT149117 Binding of CD80 and CTLA4 31 0.52 12.7 7.73
6 INT106559 Binding of Bdnf and Ntrk2 23 0.43 11.09 7.33
7 INT131249 Binding of Bdnf and Ntrk2 11 0.41 4 6.25
8 INT84921 Binding of NGF and NTRK1 13 0.50 6.39 6.1
9 INT155484 Binding of CD86 and CTLA4 15 0.52 8.85 6.09
10 INT176477 Binding of CXCR3 and CXCL10 14 0.25 10.61 5.87
11 INT269444 Binding of RAB5A and HHIP 1 0.04 0 5.79
12 INT338167 Binding of CDKN2A and MC1R 1 0.42 6.14 5.76
13 INT179502 Binding of Cd14 and Tlr4 29 0.39 13.77 5.73
14 INT95068 Tlr4 Positive_regulation of IL1B 1 0.03 4.54 5.6
15 INT88279 Ngf Positive_regulation of Ntrk1 5 0.76 3.06 5.23
16 INT166590 Binding of RAMP1 and DCLK3 2 0.37 0.39 4.8
17 INT125407 Binding of OPRL1 and PTPRM 1 0.03 0.72 4.67
18 INT182124 Binding of IRF6 and TLR4 14 0.10 16.11 4.65
19 INT139706 Tnf Positive_regulation of Ltp 1 0.03 2.61 4.63
20 INT14095 Binding of Vsig2 and Coq10a 2 0.33 1.98 4.55
21 INT128296 Negative_regulation of IL1B Positive_regulation of Insr 1 0.10 1.36 4.52
22 INT128295 IL1B Positive_regulation of Insr 1 0.11 1.36 4.5
23 INT64480 Binding of OPRL1 and PNOC 2 0.33 0.23 4.38
24 INT111758 Binding of Drd2 and Insrr 1 0.01 0.94 4.33
25 INT40114 Binding of OPRD1 and Oprm1 2 0.00 0 4.29
26 INT113223 POMC Regulation of MC1R 6 0.68 0.39 4.24
27 INT182194 Binding of IL8 and CXCR2 10 0.56 7.14 4.16
28 INT101942 Binding of CD40 and CD40LG 16 0.23 15.24 4.01
29 INT127128 Binding of CNR1 and CNR2 8 0.39 3.98 3.97
30 INT82023 Binding of Ntrk1 and Ngf 5 0.53 3.48 3.92
31 INT136514 Binding of Grm1 and Grm5 4 0.12 1.8 3.9
32 INT61359 TNF Positive_regulation of NFKB1 11 0.63 6.66 3.89
33 INT220623 Binding of Stat1 and Bace1 11 0.25 10.33 3.81
34 INT134284 Binding of OPRM1 and PLD2 1 0.52 0 3.72
35 INT104977 MITF Regulation of Gene_expression of MC1R 1 0.69 0.91 3.71
36 INT322411 Hist1h1t Positive_regulation of Positive_regulation of OPRM1 1 0.00 1.25 3.63
37 INT18026 Binding of Oprd1 and Oprm1 4 0.40 0.83 3.53
38 INT195931 Binding of OPRM1 and Trpv1 1 0.07 0.87 3.43
39 INT152035 Binding of HLA-A and MRAP 2 0.31 6.95 3.4
40 INT128293 Negative_regulation of Aldh1a1 Positive_regulation of Insr 1 0.00 0.99 3.34
41 INT128292 Nts Positive_regulation of Insr 1 0.03 0.99 3.34
42 INT128291 Vom1r68 Positive_regulation of Insr 1 0.00 0.99 3.33
43 INT128294 Aldh1a1 Positive_regulation of Insr 1 0.00 0.99 3.33
44 INT137918 Oprm1 Positive_regulation of Pdgfrb 1 0.41 0 3.31
45 INT354207 Igfbp7 Positive_regulation of Accn3 1 0.52 6.55 3.24
46 INT69823 Binding of GHR and RYBP 1 0.01 0 3.23
47 INT194647 Binding of CD28 and CD80 15 0.40 4.9 3.22
48 INT146412 Tnf Positive_regulation of Gene_expression of Trpv1 2 0.66 5.22 3.22
49 INT270949 Binding of Slc6a3 and Cpe 1 0.28 0.25 3.19
50 INT251146 Binding of Grin1 and Dlg2 1 0.36 1.95 3.16
51 INT186126 Binding of CD28 and CTLA4 9 0.52 4.13 3.12
52 INT51202 Positive_regulation of Binding of OPRK1 and PDYN 3 0.00 0.63 3.1
53 INT158752 Binding of TRPV1 and Rvm 1 0.05 1.6 3.1
54 INT101408 Binding of Grin1 and Olr1469 1 0.03 0.86 3.1
55 INT101407 Binding of Grin1 and Spr 1 0.14 0.86 3.09
56 INT158751 Binding of TRPV1 and Pag1 1 0.03 1.59 3.08
57 INT102284 Binding of Grin1 and Grin2a 5 0.27 1.79 3.01
58 INT182635 Binding of CCR5 and CCL5 2 0.09 4.19 3
59 INT123451 Binding of YY1 and Adra2a 1 0.37 0 2.98
60 INT41152 Binding of Penk and Slc3a1 3 0.12 0.11 2.91
61 INT166592 Binding of CALCA and RAMP1 2 0.35 0.33 2.91
62 INT318996 Binding of CCR3 and CCL5 1 0.07 3.39 2.9
63 INT156381 Binding of Grin1 and Dlg4 1 0.39 0.86 2.9
64 INT111757 Positive_regulation of Binding of Drd2 and Insrr 1 0.02 0.64 2.89
65 INT319003 Binding of CCR1 and CCL5 1 0.08 3.38 2.89
66 INT221746 Ngf Positive_regulation of Ntrk1 1 0.02 0.92 2.88
67 INT114126 Binding of APLNR and OPRL1 1 0.01 0.47 2.85
68 INT206764 Binding of AQP4 and Nqo1 8 0.05 13.45 2.84
69 INT106560 Binding of Ntf3 and Ntrk2 3 0.14 2.47 2.84
70 INT107723 POMC Positive_regulation of MC1R 7 0.68 0.71 2.82
71 INT175329 Binding of ICAM1 and ITGAL 14 0.18 10.06 2.81
72 INT170367 Binding of Grin1 and Grin2a 5 0.23 1.72 2.79
73 INT186128 Binding of CD2 and CD58 8 0.10 7.59 2.76
74 INT318474 Positive_regulation of OPRM1 Positive_regulation of Localization of CA2 1 0.17 0.55 2.7
75 INT220061 Binding of TRPV1 and TRPA1 1 0.15 1.7 2.69
76 INT278948 LEP Positive_regulation of Gene_expression of PTGER2 1 0.09 4.04 2.69
77 INT92738 Binding of Ephb1 and Tcas1 1 0.00 0.43 2.67
78 INT326585 Binding of GYPA and SLC6A3 1 0.13 0.86 2.64
79 INT351444 Grin1 Positive_regulation of Gria2 1 0.22 1.5 2.64
80 INT25708 Oprl1 Positive_regulation of Adra2a 1 0.25 0.15 2.63
81 INT152113 Binding of NTSR1 and Ngf 3 0.33 2.09 2.62
82 INT140024 Tnf Positive_regulation of Gene_expression of Il1b 2 0.49 2.75 2.61
83 INT121742 Prkcg Positive_regulation of Ephb1 3 0.49 0.99 2.6
84 INT67663 Ins1 Positive_regulation of Ntrk2 1 0.00 0.19 2.59
85 INT152501 Binding of Tnf and Tnfrsf1a 4 0.31 3 2.58
86 INT128044 Bdnf Positive_regulation of Ephb1 2 0.31 1.89 2.57
87 INT67905 Binding of Spn and Fosl1 1 0.24 2.1 2.54
88 INT104218 SCD Positive_regulation of CNR2 1 0.01 2.67 2.54
89 INT151826 Tnf Positive_regulation of TNF 1 0.04 3.38 2.51
90 INT107322 Positive_regulation of TRPV1 Positive_regulation of Localization of IL8 3 0.13 1.64 2.5
91 INT327940 Crh Positive_regulation of Gene_expression of F2rl1 1 0.44 5.57 2.5
92 INT317528 Ppp1r9b Regulation of Grin1 1 0.18 0.2 2.48
93 INT156799 Gria1 Regulation of Grm8 1 0.11 1.29 2.45
94 INT117532 SETBP1 Positive_regulation of Gene_expression of TNF 1 0.54 0.85 2.44
95 INT147659 Prkce Positive_regulation of TRPV1 1 0.04 1.42 2.43
96 INT143272 Binding of CNR1 and Gprasp1 1 0.01 0.17 2.42
97 INT122163 Binding of TNF and TNFRSF1B 6 0.44 6.06 2.41
98 INT103332 Ngf Regulation of Gene_expression of TRPV1 3 0.09 2.6 2.4
99 INT284088 Binding of BDNF and NTRK2 5 0.41 3.4 2.37
100 INT61733 Tlr4 Positive_regulation of Gene_expression of Tnf 3 0.26 1.99 2.36
101 INT121746 Prkaca Positive_regulation of Ephb1 2 0.23 0.92 2.35
102 INT238914 Positive_regulation of CNR1 Positive_regulation of Phosphorylation of MAPK1 1 0.19 3.22 2.35
103 INT96461 Pnoc Positive_regulation of Oprm1 1 0.09 0.73 2.34
104 INT88730 Binding of OPRM1 and Mop3 1 0.00 0 2.34
105 INT322410 Hist1h1t Positive_regulation of Phosphorylation of OPRM1 1 0.00 0.08 2.31
106 INT139705 Negative_regulation of Tnf Positive_regulation of Ltp 1 0.03 1.19 2.3
107 INT152900 TRPV1 Regulation of Gene_expression of CALCA 1 0.69 0.73 2.29
108 INT152901 TRPV1 Regulation of Localization of CALCA 1 0.44 0.73 2.29
109 INT103548 Binding of TRPV1 and TRPV3 3 0.37 1.82 2.28
110 INT106558 Binding of Ntrk2 and Ntrk3 3 0.52 2.51 2.28
111 INT156623 Umod Regulation of Phosphorylation of Ephb1 1 0.05 0.33 2.27
112 INT96652 F2rl1 Positive_regulation of Tac1 1 0.47 2.62 2.25
113 INT194646 Binding of CD28 and CD86 7 0.40 2.69 2.21
114 INT317524 Binding of Camk2a and Grin1 1 0.17 0.06 2.21
115 INT279361 Binding of TNF and KLF1 4 0.00 3.72 2.19
116 INT94491 Il1b Positive_regulation of Gene_expression of Tnf 1 0.25 3.81 2.19
117 INT94504 Il6 Positive_regulation of Gene_expression of Tnf 1 0.30 3.8 2.19
118 INT113451 Ngf Regulation of Gene_expression of ASIC3 1 0.07 1.35 2.18
119 INT86179 TNF Positive_regulation of Localization of IL6 5 0.35 1.66 2.17
120 INT184262 Binding of AGER and HMGB1 1 0.34 4.49 2.17
121 INT134583 Arrb2 Regulation of Oprm1 1 0.41 1.23 2.15
122 INT229394 TPSD1 Positive_regulation of F2RL1 2 0.00 3.11 2.14
123 INT212301 NGF Regulation of Gene_expression of TRPV1 1 0.23 2.37 2.13
124 INT318473 Positive_regulation of OPRM1 Positive_regulation of CA2 1 0.17 0.46 2.13
125 INT344386 Efnb1 Positive_regulation of Phosphorylation of Ephb2 1 0.15 2.85 2.13
126 INT273120 NOVA2 Regulation of Gene_expression of MET 1 0.23 1.17 2.11
127 INT133946 Binding of DNM2 and OPRK1 1 0.11 0 2.1
128 INT83425 Binding of CD40LG and IGHG3 11 0.21 4.56 2.09
129 INT148704 Binding of TNF and TNFRSF1A 5 0.44 3.3 2.09
130 INT196586 Negative_regulation of Mapk14 Negative_regulation of TNF 2 0.04 2.02 2.08
131 INT51198 Positive_regulation of Binding of OPRM1 and PDYN 2 0.18 0.3 2.08
132 INT51199 Binding of OPRM1 and PDYN 2 0.13 0.3 2.08
133 INT113452 Ngf Positive_regulation of Gene_expression of ASIC3 1 0.19 1.34 2.08
134 INT64750 Binding of Oprm1 and Pck1 2 0.41 0.51 2.07
135 INT182200 Binding of CXCR5 and CXCL13 1 0.37 2.89 2.07
136 INT107268 Binding of ITGAL and NCR3 1 0.01 2.76 2.07
137 INT161190 CRX Regulation of Gene_expression of Ntrk2 1 0.04 3.05 2.06
138 INT161187 NMS Regulation of Gene_expression of Ntrk2 1 0.43 3.05 2.06
139 INT140032 Tnf Positive_regulation of Gene_expression of Ifng 2 0.43 2.23 2
140 INT140026 Il1b Positive_regulation of Gene_expression of Tnf 2 0.49 2.23 2
141 INT274372 Phc1 Negative_regulation of Slc6a3 1 0.06 0.47 1.99
142 INT137917 Oprm1 Positive_regulation of Kdr 1 0.43 0 1.98
143 INT110525 Binding of MC1R and OCA2 1 0.41 1.08 1.97
144 INT2653 Slc3a1 Regulation of Penk 3 0.04 0.37 1.96
145 INT264953 Binding of POMC and TLR4 1 0.03 0.89 1.96
146 INT157767 Binding of TLR4 and LY96 8 0.54 4.05 1.95
147 INT217042 IRF6 Positive_regulation of TNF 4 0.27 3.03 1.95
148 INT129212 RYBP Positive_regulation of Tnf 2 0.03 1.9 1.95
149 INT264947 Binding of POMC and TLR2 1 0.03 0.89 1.95
150 INT156509 Il6 Regulation of Positive_regulation of Grin1 1 0.28 1.93 1.93
151 INT107738 Binding of Pld2 and Oprm1 1 0.23 0 1.93
152 INT153533 NMS Regulation of Gene_expression of Ephb1 1 0.48 3.96 1.93
153 INT104855 Prkaca Regulation of TRPV1 3 0.06 1.52 1.92
154 INT83418 Binding of OPRL1 and Ntrk1 1 0.02 0 1.91
155 INT165200 Binding of CTLA4 and Crp 1 0.09 1.64 1.91
156 INT279359 Binding of ADA and TNF 1 0.20 2.61 1.91
157 INT113572 Binding of DMRT1 and OPRM1 1 0.01 0 1.9
158 INT169570 Binding of ROS1 and TRPV1 3 0.33 3.07 1.89
159 INT95405 Trib3 Positive_regulation of Phosphorylation of Ephb1 3 0.08 1.33 1.89
160 INT151965 SORBS1 Positive_regulation of TRPV1 1 0.18 0 1.89
161 INT161224 Ccl2 Positive_regulation of Ccr2 1 0.52 2.09 1.88
162 INT297488 Itpr3 Regulation of Positive_regulation of Ltp 1 0.02 0.47 1.87
163 INT205152 Binding of CD44 and MMP9 23 0.35 17.13 1.85
164 INT112517 Binding of Ephb1 and Prkaca 3 0.18 0.58 1.85
165 INT29996 Binding of Oprm1 and Penk 2 0.36 0.4 1.85
166 INT267133 Binding of ICAM1 and VCAM1 25 0.32 25.43 1.83
167 INT72468 Negative_regulation of Binding of OPRL1 and PNOC 1 0.40 0 1.83
168 INT120732 Prkcg Positive_regulation of Phosphorylation of Grin1 2 0.48 1.04 1.81
169 INT272616 Positive_regulation of Binding of Grin1 and Grin2a 2 0.30 1.36 1.8
170 INT199287 TNF Positive_regulation of Transcription of Oprm1 2 0.02 1.86 1.8
171 INT224432 TNF Positive_regulation of Gene_expression of VEGFA 1 0.13 5.83 1.8
172 INT167319 Binding of OPRM1 and PCSK2 1 0.22 0.63 1.77
173 INT162992 Binding of Ephb1 and Ppm1e 1 0.03 0.25 1.77
174 INT167320 Binding of CPE and OPRM1 1 0.14 0.63 1.77
175 INT336556 SLC6A3 Positive_regulation of Gene_expression of GOPC 1 0.08 1.87 1.76
176 INT167321 Binding of ENG and OPRM1 1 0.27 0.63 1.76
177 INT332773 Positive_regulation of Prkaca Positive_regulation of Phosphorylation of Grin1 1 0.04 0.73 1.75
178 INT34472 Penk Regulation of Slc3a1 2 0.03 0.42 1.74
179 INT157524 Binding of GRM5 and OPRM1 1 0.36 0 1.74
180 INT14910 Binding of GPR182 and SIT1 1 0.02 1.87 1.73
181 INT165183 Ifnb1 Positive_regulation of P2rx4 1 0.04 1.73 1.73
182 INT137207 Tnf Positive_regulation of Nfkb1 3 0.23 2.69 1.71
183 INT18786 Binding of Adra2a and Nisch 2 0.19 0 1.7
184 INT157459 Binding of CX3CR1 and CX3CL1 1 0.32 2.12 1.7
185 INT167427 Mapk8 Regulation of Regulation of Tnf 1 0.26 2.83 1.7
186 INT89379 TNF Positive_regulation of Gene_expression of IL6 5 0.50 4.37 1.69
187 INT215100 Binding of Hmgb1 and Tlr4 5 0.29 3.21 1.68
188 INT102447 Binding of CALCA and CALCRL 2 0.26 0.33 1.67
189 INT105917 Binding of SLC22A6 and SLC22A8 2 0.31 0.34 1.67
190 INT108385 Binding of Crygs and Ntrk1 1 0.01 0 1.67
191 INT101926 Binding of Dio1 and Drd2 4 0.28 0.39 1.66
192 INT108066 Binding of NTRK1 and Ngf 3 0.33 2.56 1.66
193 INT18520 Adra2c Positive_regulation of Localization of Ins1 3 0.41 0.63 1.66
194 INT69666 Binding of OPRL1 and Pnoc 2 0.45 0.06 1.66
195 INT249483 Binding of Ephb1 and Efnb2 1 0.02 2.35 1.66
196 INT151889 Binding of Adarb1 and DLL1 1 0.00 0 1.66
197 INT96296 Oprm1 Negative_regulation of Npr1 2 0.05 0.32 1.65
198 INT83093 IL1B Positive_regulation of BDKRB1 1 0.51 0.44 1.65
199 INT194863 Binding of IL1R1 and IL1RN 5 0.09 2.23 1.64
200 INT172047 Binding of HLA-A and LRRC23 1 0.22 3.32 1.64

Single Events

The table below shows the top 100 pain related interactions that have been reported for integral to plasma membrane. They are ordered first by their pain relevance and then by number of times they were reported in integral to plasma membrane. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82
2 INT18357 Gene_expression of TRPV1 825 0.78 307.11 382.81
3 INT5235 Negative_regulation of TNF 924 0.59 772.91 331.98
4 INT5059 Positive_regulation of TNF 1050 0.70 896.51 322.81
5 INT63932 Positive_regulation of Ephb1 537 0.70 259.67 296.14
6 INT11624 Gene_expression of OPRM1 445 0.78 72.36 294.36
7 INT9158 Gene_expression of Tnf 722 0.78 522.01 277.68
8 INT9381 Positive_regulation of TRPV1 523 0.70 187.4 276.05
9 INT6852 Localization of TNF 883 0.81 705.95 270.84
10 INT6293 Gene_expression of Oprm1 312 0.78 48.73 215.61
11 INT6481 Binding of TNF 624 0.48 510.2 214.82
12 INT6482 Positive_regulation of Gene_expression of TNF 659 0.70 569.88 210
13 INT6488 Gene_expression of Tnf 484 0.78 339.61 191.58
14 INT63934 Phosphorylation of Ephb1 377 0.82 150.52 188.66
15 INT5930 Positive_regulation of Oprm1 221 0.70 31.19 172.93
16 INT4768 Positive_regulation of OPRM1 212 0.70 31.09 164.28
17 INT6042 Binding of Oprm1 248 0.48 31.77 154.34
18 INT49134 Gene_expression of Grin1 270 0.78 84.78 148.61
19 INT13353 Positive_regulation of Tnf 332 0.70 248.75 148.1
20 INT9660 Regulation of TNF 363 0.62 312.94 139.99
21 INT90910 Phosphorylation of Grin1 150 0.82 68.23 139.24
22 INT4658 Binding of OPRM1 188 0.48 25.96 136.24
23 INT1878 Binding of HLA-B 440 0.48 321.16 127.36
24 INT5931 Regulation of Oprm1 149 0.62 18.15 125.93
25 INT7533 Gene_expression of Tlr4 720 0.78 343.22 121.57
26 INT9235 Negative_regulation of Gene_expression of TNF 346 0.59 252.98 118.61
27 INT7341 Positive_regulation of Grin1 169 0.70 65.86 118.38
28 INT48923 Gene_expression of Ephb1 211 0.77 106.23 109.9
29 INT5906 Negative_regulation of Oprm1 125 0.59 19.58 101.57
30 INT56130 Gene_expression of MC1R 259 0.78 62.7 97.55
31 INT1760 Gene_expression of PTGER2 524 0.57 226.94 96.4
32 INT1639 Negative_regulation of OPRM1 107 0.59 13.86 90.37
33 INT10166 Localization of Tnf 237 0.81 153.95 88.64
34 INT48408 Gene_expression of ICAM1 494 0.78 340.08 88.6
35 INT5610 Positive_regulation of Insr 140 0.69 37.26 86.24
36 INT7528 Regulation of OPRM1 100 0.62 20.63 80.57
37 INT12476 Negative_regulation of TRPV1 124 0.59 47.95 77.98
38 INT9382 Regulation of TRPV1 149 0.62 53.99 77.46
39 INT749 Gene_expression of HLA-B 341 0.75 224.12 77.37
40 INT63936 Positive_regulation of Phosphorylation of Ephb1 131 0.70 49.38 73.16
41 INT9236 Regulation of Gene_expression of TNF 204 0.62 162.66 72.99
42 INT14049 Positive_regulation of GRIN1 102 0.70 48.31 71.06
43 INT58400 Negative_regulation of Tnf 182 0.59 129.97 71
44 INT49995 Positive_regulation of Gene_expression of Tnf 187 0.70 125.07 70.54
45 INT6489 Positive_regulation of Gene_expression of Tnf 140 0.70 92.31 67.85
46 INT6486 Positive_regulation of Tnf 168 0.70 123.47 66.05
47 INT6894 Gene_expression of CNR1 168 0.78 74.07 62.84
48 INT1951 Positive_regulation of Tlr4 345 0.70 176.99 62.42
49 INT50971 Gene_expression of Ntrk1 180 0.75 73.52 62.28
50 INT90911 Positive_regulation of Phosphorylation of Grin1 62 0.70 27.45 59.26
51 INT20964 Gene_expression of OPRK1 96 0.78 23.54 58.18
52 INT7340 Regulation of Grin1 87 0.62 30.37 57.93
53 INT21737 Binding of MC1R 129 0.48 45.45 56.54
54 INT83602 Positive_regulation of Gene_expression of TRPV1 114 0.70 51.19 56.35
55 INT52800 Negative_regulation of Gene_expression of Tnf 142 0.59 92.27 55.47
56 INT49436 Binding of TRPV1 145 0.48 38.35 55.08
57 INT5034 Negative_regulation of Insr 100 0.55 28.08 54.5
58 INT117223 Gene_expression of TLR4 348 0.78 206.18 54.42
59 INT37219 Gene_expression of TACR1 56 0.78 32.4 54.16
60 INT84495 Positive_regulation of Positive_regulation of Ephb1 85 0.70 46.12 54.11
61 INT49747 Transcription of Oprm1 68 0.72 9.01 53.78
62 INT15091 Gene_expression of SLC6A4 101 0.78 29.91 53.64
63 INT4957 Negative_regulation of Grin1 87 0.59 24.51 53.21
64 INT69484 Positive_regulation of Gene_expression of OPRM1 75 0.70 12.86 52.27
65 INT22112 Positive_regulation of Localization of TNF 164 0.70 115.66 52.18
66 INT5704 Binding of Slc3a1 78 0.43 8.52 51.78
67 INT62630 Positive_regulation of CNR1 86 0.70 40.34 51.51
68 INT48920 Negative_regulation of Ephb1 107 0.57 43.6 51.02
69 INT10304 Binding of OPRK1 89 0.48 9.28 49.42
70 INT17915 Gene_expression of Insr 141 0.75 47.45 48.59
71 INT7059 Regulation of Adra2a 89 0.62 18.24 48.43
72 INT32718 Gene_expression of OPRD1 82 0.76 9.43 48.38
73 INT66029 Negative_regulation of Tnf 100 0.59 84.28 48.16
74 INT57021 Positive_regulation of Gene_expression of Grin1 62 0.70 24.77 47.31
75 INT55670 Negative_regulation of Gene_expression of Tnf 83 0.59 57.16 46.33
76 INT9383 Localization of TRPV1 98 0.81 33.23 46.24
77 INT2783 Gene_expression of Slc3a1 86 0.65 8.84 45.4
78 INT16364 Gene_expression of HLA-DRA 234 0.78 118.81 45.01
79 INT29105 Positive_regulation of OPRK1 68 0.70 7.06 44.69
80 INT1564 Localization of OPRM1 41 0.80 8.03 44.67
81 INT4216 Gene_expression of CD40LG 328 0.78 256.02 44.23
82 INT5307 Regulation of Tnf 87 0.62 78.71 43.4
83 INT27798 Gene_expression of Ntrk2 111 0.78 56.08 42.68
84 INT13354 Transcription of TNF 108 0.72 85.81 42.32
85 INT48929 Regulation of Ephb1 71 0.62 24.42 42.11
86 INT88322 Gene_expression of CCR5 111 0.78 77.36 39.84
87 INT16194 Binding of CNR1 82 0.48 20.75 39.59
88 INT102902 Gene_expression of Ntrk2 152 0.78 81.52 39.43
89 INT92517 Gene_expression of Grin1 105 0.78 29.53 39.43
90 INT16455 Gene_expression of Drd2 116 0.78 22.71 38.47
91 INT81037 Negative_regulation of Slc6a3 70 0.59 15.31 37.01
92 INT11246 Binding of Grin1 65 0.48 14.53 36.93
93 INT62827 Positive_regulation of ICAM1 184 0.70 180.95 36.28
94 INT133028 Gene_expression of TLR2 209 0.73 131.92 36.17
95 INT14137 Localization of Oprm1 56 0.81 2.88 36.09
96 INT12608 Regulation of CNR1 62 0.60 24.36 36.02
97 INT77407 Regulation of Gene_expression of OPRM1 51 0.62 12.58 35.75
98 INT13501 Binding of Drd2 65 0.48 23.76 35.6
99 INT53577 Negative_regulation of Localization of TNF 110 0.59 59.28 35.23
100 INT100733 Positive_regulation of F2RL1 62 0.70 59.14 35.22
101 INT7608 Positive_regulation of Adra2a 66 0.70 17.81 35.15
102 INT98521 Gene_expression of Accn2 52 0.74 23.45 35.09
103 INT52194 Positive_regulation of Grin1 83 0.69 25.09 34.76
104 INT49519 Gene_expression of P2rx7 84 0.76 36.88 34.69
105 INT47710 Negative_regulation of GRIN1 71 0.57 25.57 34.24
106 INT81289 Positive_regulation of Gene_expression of Tlr4 192 0.69 104.5 33.89
107 INT33768 Positive_regulation of Cysltr1 87 0.46 54.66 33.52
108 INT48907 Positive_regulation of Gene_expression of Oprm1 53 0.69 8.55 33.52
109 INT63933 Negative_regulation of Positive_regulation of Ephb1 53 0.58 22.83 33.43
110 INT84825 Gene_expression of CD36 121 0.78 43.73 33.23
111 INT7133 Negative_regulation of MME 85 0.59 29.22 33.1
112 INT63935 Positive_regulation of Gene_expression of Ephb1 52 0.61 24.3 33.05
113 INT57024 Regulation of Gene_expression of Grin1 32 0.62 9.77 32.6
114 INT14823 Gene_expression of MET 103 0.75 51.92 32.48
115 INT6683 Gene_expression of Drd2 64 0.78 11.31 32.28
116 INT51685 Gene_expression of LTB4R 87 0.58 68.69 31.72
117 INT124860 Gene_expression of Bace1 330 0.78 157.11 31.65
118 INT35406 Localization of Tnf 94 0.81 64.63 31.65
119 INT11087 Positive_regulation of Drd2 54 0.69 12.4 31.43
120 INT56809 Binding of Tlr4 184 0.48 106.02 31.18
121 INT10285 Binding of ADRA1D 102 0.47 25.82 31.11
122 INT121663 Gene_expression of CXCR3 76 0.77 50.96 30.62
123 INT7845 Regulation of OPRK1 44 0.62 4.54 30.49
124 INT8691 Localization of Insr 85 0.80 9.27 30.32
125 INT69483 Transcription of OPRM1 45 0.72 7.31 30.22
126 INT130837 Gene_expression of Aqp4 205 0.78 151.23 29.63
127 INT67912 Gene_expression of GRIN1 75 0.77 28.99 29.28
128 INT5300 Regulation of Insr 54 0.60 11.33 29.26
129 INT106540 Negative_regulation of Phosphorylation of Grin1 15 0.58 9.32 29.13
130 INT49431 Phosphorylation of OPRM1 31 0.82 2.2 29.09
131 INT104567 Gene_expression of Aqp1 47 0.78 44.84 28.68
132 INT84494 Negative_regulation of Phosphorylation of Ephb1 44 0.59 22.34 28.68
133 INT98522 Gene_expression of Accn3 68 0.78 26.95 28.6
134 INT10506 Gene_expression of PTAFR 86 0.76 37.57 28.58
135 INT182223 Gene_expression of CXCR5 57 0.76 51.49 28.4
136 INT91775 Gene_expression of Slc6a4 102 0.78 26.45 28.23
137 INT118734 Gene_expression of Tlr4 70 0.78 55.7 28.19
138 INT7779 Negative_regulation of Adra2a 47 0.58 9.45 28
139 INT74726 Negative_regulation of Slc6a4 61 0.59 21.01 27.84
140 INT62169 Positive_regulation of MC1R 72 0.69 14.56 27.52
141 INT2650 Positive_regulation of Slc3a1 50 0.57 2.95 27.52
142 INT94658 Positive_regulation of F2rl1 51 0.70 33.65 27.46
143 INT5604 Positive_regulation of Drd2 47 0.67 10.75 27.41
144 INT7717 Positive_regulation of Adra2a 62 0.70 17.68 27.32
145 INT123035 Gene_expression of Ephb1 38 0.78 28.84 27.32
146 INT80470 Negative_regulation of Gene_expression of Grin1 33 0.59 10.22 27.15
147 INT6594 Gene_expression of HTR1D 60 0.75 10.15 27.13
148 INT1765 Positive_regulation of Gene_expression of PTGER2 140 0.51 68.68 27
149 INT127499 Positive_regulation of TRPA1 72 0.70 21.7 26.86
150 INT52801 Regulation of Gene_expression of Tnf 55 0.62 48.74 26.59
151 INT93360 Gene_expression of Slc6a3 63 0.78 19.54 26.55
152 INT19856 Gene_expression of CD8A 240 0.75 147.86 26.39
153 INT95481 Regulation of Gene_expression of TRPV1 48 0.62 29.3 26.28
154 INT1761 Positive_regulation of PTGER2 135 0.49 90.17 26.26
155 INT80791 Gene_expression of Slc6a3 113 0.78 11.89 25.76
156 INT6934 Binding of OPRD1 51 0.48 7.72 25.73
157 INT12392 Regulation of Slc3a1 45 0.36 7.57 25.66
158 INT15089 Regulation of SLC6A4 48 0.62 17.87 25.6
159 INT140413 Gene_expression of AQP4 113 0.78 139.25 25.53
160 INT79979 Gene_expression of Ret 94 0.75 19.21 25.51
161 INT61664 Regulation of GRIN1 38 0.60 16.45 25.35
162 INT9781 Binding of INSRR 64 0.31 19.1 25.2
163 INT81496 Gene_expression of CNR2 68 0.75 30.04 24.92
164 INT76743 Gene_expression of Slc6a4 55 0.76 13.53 24.9
165 INT4877 Gene_expression of MME 184 0.78 122.82 24.78
166 INT12484 Binding of Drd2 45 0.48 15.17 24.72
167 INT23937 Gene_expression of EDNRA 103 0.65 55.63 24.67
168 INT9377 Positive_regulation of Positive_regulation of TRPV1 43 0.70 15.81 24.47
169 INT18400 Localization of Glp1r 97 0.80 11.96 24.32
170 INT22708 Gene_expression of MUC1 297 0.78 232.71 24.19
171 INT44954 Gene_expression of APP 191 0.78 105.86 23.9
172 INT100124 Gene_expression of Accn3 38 0.78 30.02 23.63
173 INT48536 Positive_regulation of Grm8 46 0.61 14.31 23.56
174 INT127500 Gene_expression of TRPA1 79 0.78 24.58 23.3
175 INT134651 Binding of TLR4 89 0.48 66.96 23.19
176 INT12475 Gene_expression of OPRL1 35 0.77 3.63 23.11
177 INT30386 Negative_regulation of OPRD1 33 0.52 4.34 23.06
178 INT9282 Gene_expression of HTR1B 48 0.75 12.15 22.94
179 INT6270 Binding of HTR1D 55 0.47 9.54 22.86
180 INT19330 Binding of HLA-A 99 0.48 76.26 22.85
181 INT50970 Positive_regulation of Ntrk1 51 0.57 29.38 22.83
182 INT6294 Regulation of Gene_expression of Oprm1 28 0.62 6.77 22.79
183 INT825 Negative_regulation of ADRA1D 54 0.58 20.25 22.78
184 INT11077 Positive_regulation of Htr3a 63 0.67 15.61 22.7
185 INT88327 Gene_expression of P2rx7 109 0.77 48.86 22.41
186 INT66753 Negative_regulation of Positive_regulation of Tnf 45 0.59 35.28 22.33
187 INT7715 Regulation of Drd2 35 0.62 10.79 22.3
188 INT48312 Gene_expression of NTRK1 72 0.78 38.21 22.24
189 INT8248 Binding of Adra2a 43 0.48 6.72 22.17
190 INT8483 Positive_regulation of Positive_regulation of TNF 73 0.67 60.35 22.03
191 INT78057 Localization of Tlr4 140 0.77 67.75 21.72
192 INT116856 Gene_expression of TNFSF10 110 0.75 115.76 21.48
193 INT5916 Positive_regulation of HTR1A 51 0.67 18.27 21.38
194 INT7535 Negative_regulation of Tlr4 111 0.56 56.84 21.37
195 INT61825 Negative_regulation of Slc6a3 47 0.59 6.52 21.27
196 INT1876 Positive_regulation of HLA-B 82 0.69 52.16 21.08
197 INT11161 Gene_expression of HLA-DRB1 121 0.78 75.33 20.96
198 INT3593 Gene_expression of ADRA1D 70 0.75 29.48 20.87
199 INT99237 Gene_expression of Ntrk3 84 0.77 38.68 20.77
200 INT56769 Gene_expression of Ntrk1 36 0.77 15.79 20.75
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