GO:0005899

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Name insulin receptor complex
Categary Component
Go Slim No
Go Link GO:0005899
Unique Molecular Interactions 129
Total Molecular Interactions 197
Total Single Events 2202
Pain Genes Associated 7

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for insulin receptor complex. They are ordered first by their pain relevance and then by number of times they were reported for insulin receptor complex. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT128296 Negative_regulation of IL1B Positive_regulation of Insr 1 0.10 1.36 4.52
2 INT128295 IL1B Positive_regulation of Insr 1 0.11 1.36 4.5
3 INT128293 Negative_regulation of Aldh1a1 Positive_regulation of Insr 1 0.00 0.99 3.34
4 INT128292 Nts Positive_regulation of Insr 1 0.03 0.99 3.34
5 INT128291 Vom1r68 Positive_regulation of Insr 1 0.00 0.99 3.33
6 INT128294 Aldh1a1 Positive_regulation of Insr 1 0.00 0.99 3.33
7 INT151965 SORBS1 Positive_regulation of TRPV1 1 0.18 0 1.89
8 INT89011 Lep Positive_regulation of Insr 1 0.19 2.41 1.57
9 INT290542 Crh Positive_regulation of Insr 1 0.02 0.36 1.36
10 INT114068 Agtr2 Regulation of Gene_expression of Insr 1 0.15 0.95 0.79
11 INT181616 INS Positive_regulation of IRS1 1 0.01 1 0.79
12 INT181615 SRC Positive_regulation of IRS1 1 0.01 0.98 0.77
13 INT76499 Binding of Insr and Adora2a 1 0.08 0 0.76
14 INT290544 Negative_regulation of Crh Positive_regulation of Insr 1 0.01 0.3 0.72
15 INT290549 Gopc Positive_regulation of Positive_regulation of Insr 1 0.01 0.06 0.65
16 INT290545 Crh Positive_regulation of Positive_regulation of Insr 1 0.02 0.06 0.64
17 INT290550 Gopc Positive_regulation of Insr 1 0.01 0.06 0.64
18 INT290540 Positive_regulation of Crh Positive_regulation of Insr 1 0.02 0.06 0.64
19 INT46493 Binding of Insr and Oxt 1 0.14 0 0.62
20 INT276217 Pdk1 Positive_regulation of Positive_regulation of Insr 1 0.05 0.1 0.6
21 INT89010 Arc Positive_regulation of Insr 1 0.08 0.86 0.59
22 INT89012 DST Positive_regulation of Insr 1 0.01 0.86 0.59
23 INT114070 Agtr2 Positive_regulation of Gene_expression of Insr 1 0.13 0.34 0.52
24 INT114065 Akt1 Regulation of Gene_expression of Insr 1 0.13 0.28 0.46
25 INT280614 Il6 Regulation of Transcription of Irs1 1 0.26 0.4 0.46
26 INT37599 Ace Regulation of Localization of Insr 1 0.18 0 0.46
27 INT348784 Ins1 Positive_regulation of Irs1 1 0.09 3.47 0.44
28 INT114067 Ace Regulation of Insr 1 0.09 0.31 0.39
29 INT336573 Ptpn2 Regulation of INSR 1 0.00 1.36 0.36
30 INT242403 INSR Positive_regulation of Gene_expression of Bdkrb1 1 0.45 0.88 0.35
31 INT246841 Binding of Irs1 and Ppp1r13b 5 0.16 0.94 0.28
32 INT41406 Binding of Insr and Thtpa 1 0.05 0 0.25
33 INT89158 Grpr Positive_regulation of Localization of Insr 1 0.02 0 0.23
34 INT280621 Il6 Negative_regulation of Transcription of Irs1 1 0.25 0.4 0.19
35 INT255736 Mapk8 Positive_regulation of Phosphorylation of Irs1 1 0.14 2.31 0.16
36 INT246843 Positive_regulation of Binding of Irs1 and Ppp1r13b 1 0.18 0.28 0.16
37 INT246844 Binding of Irs1 and Myl7 1 0.05 0.43 0.11
38 INT349660 Binding of INSR and PYCARD 1 0.01 0 0.09
39 INT301655 Irs1 Negative_regulation of Transcription of Pck1 1 0.03 0.65 0.08
40 INT325059 Insr Positive_regulation of Ang 1 0.02 1.4 0.08
41 INT115258 Insr Positive_regulation of Phosphorylation of Irs1 1 0.19 0.26 0.08
42 INT301619 Positive_regulation of Irs1 Positive_regulation of Gene_expression of Srebf1 1 0.10 0.67 0.08
43 INT246846 Binding of PIK3CA and Irs1 1 0.39 0.14 0.08
44 INT332287 LEP Positive_regulation of Phosphorylation of IRS1 1 0.20 1.48 0.08
45 INT301631 Gene_expression of Mapk8 Positive_regulation of Phosphorylation of Irs1 1 0.09 0.72 0.08
46 INT301649 Irs1 Negative_regulation of Transcription of G6pc 1 0.05 0.65 0.08
47 INT246839 Binding of Irs1 and Gopc 1 0.16 0.15 0.08
48 INT17920 Penk Positive_regulation of Insr 1 0.05 0.14 0.06
49 INT246842 Binding of Ins1 and Irs1 1 0.16 0.63 0.06
50 INT240873 Ins1 Positive_regulation of Phosphorylation of Irs1 1 0.05 0 0.05
51 INT184123 Socs3 Positive_regulation of Protein_catabolism of Insr 1 0.03 0.41 0.05
52 INT267158 Binding of IRS1 and SHMT2 1 0.02 0.46 0.05
53 INT325060 Binding of Insr and Hand1 1 0.00 0.16 0.05
54 INT184085 Socs1 Positive_regulation of Protein_catabolism of Insr 1 0.04 0.41 0.05
55 INT240893 Negative_regulation of Ros1 Positive_regulation of Phosphorylation of Irs1 1 0.08 0.36 0.04
56 INT342170 Insr Regulation of Localization of Cd320 1 0.08 0.92 0.04
57 INT301647 Negative_regulation of Mapk8 Positive_regulation of Irs1 1 0.08 0.83 0.04
58 INT301626 Mapk8 Positive_regulation of Irs1 1 0.09 0.83 0.04
59 INT225800 Binding of Insr and Enpp1 1 0.05 0.67 0.04
60 INT321407 EDN1 Positive_regulation of Phosphorylation of IRS1 1 0.06 1.07 0.03
61 INT207555 GH1 Negative_regulation of Phosphorylation of IRS1 1 0.10 0.28 0.03
62 INT332284 IRS1 Regulation of PIK3CD 1 0.15 0.72 0.03
63 INT246834 Phosphorylation of Irs1 Negative_regulation of Ins1 1 0.14 0.44 0.03
64 INT179950 Binding of PIK3CA and Irs1 1 0.32 0.31 0.03
65 INT179949 Binding of Ins1 and Irs1 1 0.31 0.32 0.03
66 INT332288 Positive_regulation of IRS1 Regulation of PIK3CD 1 0.07 0.73 0.03
67 INT144761 Binding of INSR and Insr 1 0.05 0 0
68 INT289672 Binding of GNRH1 and INSR 1 0.02 0 0
69 INT235623 Binding of INS and INSR 1 0.14 0.47 0
70 INT284311 RPS6KB1 Positive_regulation of Phosphorylation of IRS1 1 0.18 0.24 0
71 INT342358 Binding of Irs1 and Erap1 1 0.37 0 0
72 INT144754 Negative_regulation of Binding of Insr and Slc2a2 1 0.01 0 0
73 INT280615 Fig4 Regulation of Gene_expression of Irs1 1 0.05 0 0
74 INT321722 Negative_regulation of Binding of Irs1 and Ppp1r13b 1 0.20 0.07 0
75 INT191698 Binding of TAT and SORBS1 1 0.01 1.08 0
76 INT277315 Binding of Insr and Mbnl1 1 0.18 1.1 0
77 INT321715 Regulation of Binding of Irs1 and Ppp1r13b 1 0.15 0.05 0
78 INT304350 INS Positive_regulation of Protein_catabolism of IRS1 1 0.09 0.78 0
79 INT240880 Mapk8 Positive_regulation of Protein_catabolism of Irs1 1 0.21 0.14 0
80 INT235624 INS Regulation of Phosphorylation of INSR 1 0.08 0.26 0
81 INT173127 Binding of INS and SORBS1 1 0.02 0.22 0
82 INT304347 INS Positive_regulation of Phosphorylation of IRS1 1 0.09 0.77 0
83 INT271281 Gene_expression of Stat1 Positive_regulation of Insr 1 0.19 0.51 0
84 INT271287 Gene_expression of IFNA1 Positive_regulation of Insr 1 0.03 0.51 0
85 INT308664 Akt1 Positive_regulation of Phosphorylation of Insr 1 0.02 0.43 0
86 INT144760 Binding of ABCA1 and Insr 1 0.00 0 0
87 INT342360 Binding of H2-K1 and Irs1 1 0.10 0 0
88 INT240900 Negative_regulation of Ros1 Positive_regulation of Gene_expression of Irs1 1 0.08 0.13 0
89 INT323495 Ghrl Positive_regulation of Irs1 1 0.20 0.5 0
90 INT342361 Binding of Irs1 and Rdh9 1 0.38 0 0
91 INT218307 Grb10 Positive_regulation of Protein_catabolism of INSR 1 0.03 0 0
92 INT284313 Binding of IRS1 and SART3 1 0.07 0.32 0
93 INT144753 Binding of Insr and Slc2a2 1 0.01 0 0
94 INT342362 Binding of Irs1 and Rara 1 0.15 0 0
95 INT284312 Negative_regulation of Binding of IRS1 and SART3 1 0.08 0.32 0
96 INT311383 Mbnl1 Regulation of Insr 1 0.00 0.24 0
97 INT240901 Negative_regulation of Ros1 Negative_regulation of Phosphorylation of Irs1 1 0.07 0.15 0
98 INT144762 Negative_regulation of Binding of INSR and Insr 1 0.06 0 0
99 INT321713 Ins1 Positive_regulation of Irs1 1 0.04 0.05 0
100 INT311386 Celf1 Regulation of Insr 1 0.00 0.24 0
101 INT342357 Binding of Irs1 and Irf6 1 0.37 0 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for insulin receptor complex. They are ordered first by their pain relevance and then by number of times they were reported in insulin receptor complex. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT5610 Positive_regulation of Insr 140 0.69 37.26 86.24
2 INT5034 Negative_regulation of Insr 100 0.55 28.08 54.5
3 INT17915 Gene_expression of Insr 141 0.75 47.45 48.59
4 INT8691 Localization of Insr 85 0.80 9.27 30.32
5 INT5300 Regulation of Insr 54 0.60 11.33 29.26
6 INT14768 Negative_regulation of Positive_regulation of Insr 16 0.56 5.51 13.59
7 INT110988 Gene_expression of Insr 58 0.42 42.12 12.18
8 INT30920 Positive_regulation of Gene_expression of Insr 14 0.66 2.91 7.32
9 INT36405 Positive_regulation of Insr 26 0.66 24.5 7.24
10 INT24622 Positive_regulation of Localization of Insr 15 0.69 0.32 6.85
11 INT32611 Phosphorylation of Insr 13 0.80 4.18 5.77
12 INT14769 Positive_regulation of Positive_regulation of Insr 10 0.43 2.66 5.55
13 INT114058 Negative_regulation of Gene_expression of Insr 13 0.31 9.23 4.97
14 INT10115 Gene_expression of INSR 31 0.75 11.98 4.86
15 INT51392 Negative_regulation of Insr 18 0.27 14.75 4.84
16 INT24620 Negative_regulation of Gene_expression of Insr 14 0.39 6.98 4.61
17 INT51084 Binding of Insr 13 0.30 4.25 4.23
18 INT230796 Phosphorylation of Irs1 70 0.81 31.73 4.13
19 INT83035 Binding of INSR 16 0.47 9.29 4.11
20 INT10116 Localization of INSR 11 0.57 5.43 3.48
21 INT14060 Negative_regulation of Negative_regulation of Insr 6 0.53 3.53 3.44
22 INT207570 Phosphorylation of IRS1 45 0.71 33.27 3.42
23 INT106341 Phosphorylation of Irs1 18 0.72 14.7 3.3
24 INT124736 Positive_regulation of Gene_expression of Insr 6 0.31 7.55 3.12
25 INT106340 Positive_regulation of Phosphorylation of Irs1 8 0.53 7.03 2.85
26 INT23527 Negative_regulation of Localization of Insr 10 0.39 2.58 2.5
27 INT24621 Regulation of Gene_expression of Insr 9 0.42 2.68 2.18
28 INT31006 Regulation of Localization of Insr 7 0.50 0.2 2.05
29 INT237322 Gene_expression of Irs1 52 0.77 21.07 2
30 INT114059 Localization of Insr 10 0.46 3.49 1.87
31 INT218303 Protein_catabolism of INSR 3 0.29 0.67 1.73
32 INT232645 Transcription of INSR 2 0.09 1.19 1.71
33 INT230799 Positive_regulation of Phosphorylation of Irs1 28 0.69 11.17 1.63
34 INT114061 Regulation of Gene_expression of Insr 4 0.27 2.03 1.56
35 INT19342 Regulation of Insr 12 0.24 6.11 1.54
36 INT240031 Positive_regulation of Phosphorylation of IRS1 15 0.46 13.17 1.53
37 INT240842 Positive_regulation of Gene_expression of Irs1 31 0.69 12 1.31
38 INT120970 Negative_regulation of Irs1 12 0.37 8.65 1.28
39 INT124738 Negative_regulation of Positive_regulation of Insr 5 0.23 3.73 1.24
40 INT10117 Positive_regulation of INSR 10 0.43 4.71 1.22
41 INT106339 Positive_regulation of Phosphorylation of Insr 1 0.49 0 1.12
42 INT32354 Negative_regulation of Regulation of Insr 3 0.33 0.13 1.08
43 INT145864 Gene_expression of Irs1 5 0.71 3.34 1.01
44 INT171382 Phosphorylation of Insr 6 0.51 3.41 0.94
45 INT41911 Regulation of Positive_regulation of Insr 2 0.21 0.32 0.88
46 INT171376 Positive_regulation of Phosphorylation of Insr 3 0.31 3.05 0.86
47 INT91908 Regulation of Negative_regulation of Insr 1 0.03 0.81 0.86
48 INT240849 Negative_regulation of Phosphorylation of Irs1 11 0.43 4.74 0.85
49 INT89407 Positive_regulation of IRS1 10 0.51 9.67 0.81
50 INT144759 Regulation of Gene_expression of INSR 2 0.44 3.09 0.77
51 INT321433 Negative_regulation of IRS1 3 0.32 5.41 0.75
52 INT117392 Binding of Insr 8 0.23 4.88 0.68
53 INT280678 Transcription of Irs1 1 0.45 0.87 0.68
54 INT171366 Positive_regulation of Localization of Insr 3 0.18 0.63 0.66
55 INT242655 Binding of Irs1 1 0.29 1.45 0.66
56 INT18445 Regulation of Transcription of Insr 1 0.12 0.84 0.63
57 INT18446 Transcription of Insr 2 0.18 0.84 0.62
58 INT284334 Gene_expression of IRS1 10 0.49 5.81 0.59
59 INT115255 Negative_regulation of Phosphorylation of Irs1 6 0.45 3.71 0.56
60 INT246832 Positive_regulation of Irs1 16 0.69 7.33 0.55
61 INT308979 Regulation of Localization of Insr 1 0.24 0.44 0.53
62 INT321417 Positive_regulation of Negative_regulation of IRS1 1 0.12 3.82 0.51
63 INT158517 Regulation of Irs1 2 0.39 1.02 0.5
64 INT246828 Binding of Irs1 9 0.37 2.68 0.42
65 INT235635 Negative_regulation of Phosphorylation of IRS1 7 0.37 3.78 0.42
66 INT145861 Regulation of Gene_expression of Irs1 2 0.41 0.83 0.41
67 INT145863 Negative_regulation of Gene_expression of Irs1 3 0.45 1.51 0.4
68 INT114062 Negative_regulation of Localization of Insr 1 0.19 0.31 0.39
69 INT144755 Negative_regulation of INSR 5 0.41 2.09 0.36
70 INT158521 Positive_regulation of Negative_regulation of Irs1 1 0.02 0.57 0.33
71 INT83030 Positive_regulation of Binding of INSR 2 0.49 2.35 0.31
72 INT278530 Regulation of Positive_regulation of Insr 1 0.01 1.96 0.28
73 INT240830 Positive_regulation of Protein_catabolism of Irs1 2 0.69 0.82 0.26
74 INT124735 Positive_regulation of Positive_regulation of Insr 1 0.08 0 0.25
75 INT115253 Negative_regulation of Phosphorylation of Insr 1 0.27 0.56 0.25
76 INT246817 Positive_regulation of Binding of Irs1 1 0.50 0.37 0.23
77 INT240818 Protein_catabolism of Irs1 3 0.98 1 0.22
78 INT89406 Negative_regulation of Positive_regulation of IRS1 1 0.22 0.93 0.22
79 INT246824 Negative_regulation of Irs1 6 0.43 2.13 0.17
80 INT284323 Regulation of IRS1 2 0.45 1.6 0.16
81 INT240841 Regulation of Gene_expression of Irs1 3 0.45 0.75 0.15
82 INT120962 Negative_regulation of Negative_regulation of Irs1 1 0.25 0.38 0.15
83 INT301563 Positive_regulation of Positive_regulation of Irs1 1 0.16 1.32 0.15
84 INT230807 Regulation of Phosphorylation of Irs1 3 0.45 1.59 0.13
85 INT92634 Negative_regulation of Binding of Insr 1 0.25 0.08 0.12
86 INT308981 Positive_regulation of Negative_regulation of Insr 1 0.27 0.95 0.11
87 INT323945 Positive_regulation of Binding of Insr 1 0.08 0.94 0.11
88 INT246818 Negative_regulation of Gene_expression of Irs1 3 0.42 1.25 0.1
89 INT304385 Protein_catabolism of IRS1 2 0.42 1.8 0.1
90 INT240850 Regulation of Irs1 2 0.47 0.64 0.09
91 INT246825 Regulation of Positive_regulation of Irs1 1 0.45 0.47 0.09
92 INT246819 Negative_regulation of Binding of Irs1 3 0.42 0.62 0.07
93 INT184013 Protein_catabolism of Insr 1 0.05 0.4 0.04
94 INT301556 Negative_regulation of Positive_regulation of Irs1 1 0.10 1.63 0.04
95 INT332299 Negative_regulation of Gene_expression of IRS1 1 0.31 0.65 0.04
96 INT235632 Binding of IRS1 2 0.28 1.01 0.03
97 INT117362 Positive_regulation of Positive_regulation of INSR 1 0.22 0.1 0.03
98 INT284335 Regulation of Gene_expression of IRS1 1 0.18 0.06 0.03
99 INT235634 Phosphorylation of INSR 24 0.70 3.64 0
100 INT215947 Positive_regulation of Gene_expression of INSR 2 0.14 0.25 0
101 INT173193 Binding of SORBS1 2 0.14 1.29 0
102 INT246829 Localization of Irs1 2 0.74 0.9 0
103 INT246826 Positive_regulation of Localization of Irs1 1 0.50 0.76 0
104 INT144758 Negative_regulation of Negative_regulation of INSR 1 0.41 0 0
105 INT235628 Negative_regulation of Phosphorylation of INSR 1 0.16 0.25 0
106 INT230481 Positive_regulation of Regulation of Insr 1 0.01 0.24 0
107 INT323089 Positive_regulation of Transcription of Irs1 1 0.44 0.26 0
108 INT304382 Positive_regulation of Protein_catabolism of IRS1 1 0.16 0.77 0
109 INT144756 Positive_regulation of Negative_regulation of INSR 1 0.49 0 0
110 INT144757 Negative_regulation of Gene_expression of INSR 1 0.41 0 0
111 INT284324 Positive_regulation of Gene_expression of IRS1 1 0.31 0.24 0
112 INT323107 Transcription of Irs1 1 0.50 0.26 0
113 INT280661 Negative_regulation of Transcription of Irs1 1 0.37 0 0
114 INT304383 Negative_regulation of Protein_catabolism of IRS1 1 0.15 0.77 0
115 INT339743 Positive_regulation of SORBS1 1 0.06 0.39 0
116 INT179948 Negative_regulation of Positive_regulation of Irs1 1 0.45 0.36 0
117 INT235630 Localization of IRS1 1 0.70 0.38 0
118 INT179947 Positive_regulation of Irs1 1 0.53 0.83 0
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