GO:0005921

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Name gap junction
Categary Component
Go Slim No
Go Link GO:0005921
Unique Molecular Interactions 77
Total Molecular Interactions 99
Total Single Events 1458
Pain Genes Associated 19

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for gap junction. They are ordered first by their pain relevance and then by number of times they were reported for gap junction. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT334131 Acsm3 Positive_regulation of Mip 1 0.13 3.12 1.48
2 INT128653 ITIH4 Regulation of Gene_expression of MIP 1 0.23 1.44 0.92
3 INT334130 Negative_regulation of Acsm3 Positive_regulation of Mip 1 0.12 1.48 0.81
4 INT334134 Acsm3 Positive_regulation of Gene_expression of Mip 1 0.13 1.4 0.77
5 INT128404 Mapk1 Positive_regulation of Phosphorylation of Gja1 1 0.65 0.73 0.73
6 INT155610 FPR1 Positive_regulation of Phosphorylation of SGSM3 1 0.04 0.68 0.71
7 INT199395 Mip Positive_regulation of Positive_regulation of Trpv1 1 0.01 0.86 0.69
8 INT2687 Negative_regulation of Binding of Thra and SGSM3 1 0.43 0.1 0.62
9 INT2686 Binding of Thra and SGSM3 1 0.36 0.1 0.61
10 INT144129 Prkce Positive_regulation of Phosphorylation of Gja1 1 0.42 0.48 0.55
11 INT144128 Binding of Gja1 and Prkce 1 0.40 0.5 0.52
12 INT144130 Binding of Gja1 and Prkcg 1 0.48 0.5 0.52
13 INT202969 Positive_regulation of SGSM3 Positive_regulation of MCRS1 1 0.02 1.22 0.47
14 INT202964 SGSM3 Positive_regulation of MCRS1 1 0.03 1.21 0.47
15 INT112772 Binding of Bcl2 and SGSM3 1 0.02 0.69 0.45
16 INT335996 Mmp8 Regulation of Protein_catabolism of MIP 1 0.44 1.06 0.43
17 INT109711 Mip Positive_regulation of Rtcd1 1 0.00 0 0.29
18 INT122873 SEMA6A Positive_regulation of SGSM3 1 0.54 0 0.26
19 INT268768 Mip Regulation of Positive_regulation of Ccr1 1 0.44 0.83 0.23
20 INT217349 Mip Positive_regulation of IL8 1 0.05 1.28 0.22
21 INT182634 Binding of CCR5 and MIP 2 0.39 1.29 0.2
22 INT217528 Binding of Tjp1 and Vapb 1 0.00 1.6 0.19
23 INT302372 Arx Negative_regulation of Gene_expression of Calb2 1 0.13 0.05 0.18
24 INT221234 Gja3 Regulation of Binding of Ptpn2 1 0.08 0.58 0.18
25 INT308533 ITIH4 Positive_regulation of Protein_catabolism of Tjp2 1 0.01 1.28 0.18
26 INT270827 P2rx7 Positive_regulation of Localization of Panx1 1 0.41 0.18 0.13
27 INT217530 Binding of Tjp1 and Tjp2 1 0.10 0.91 0.1
28 INT270834 CBX1 Negative_regulation of Transcription of Panx1 1 0.06 0.13 0.1
29 INT270837 Negative_regulation of Panx1 Negative_regulation of Transcription of CBX1 1 0.07 0.13 0.1
30 INT265346 Binding of Ocln and Tjp1 7 0.05 1.11 0.09
31 INT252421 Gja1 Regulation of P2ry1 1 0.00 0.28 0.09
32 INT270833 Binding of CASP1 and Panx1 1 0.02 0.14 0.09
33 INT270824 Binding of P2rx7 and Panx1 1 0.34 0.15 0.09
34 INT270830 Panx1 Negative_regulation of CASP1 1 0.03 0.09 0.09
35 INT270832 Negative_regulation of Panx1 Negative_regulation of Gene_expression of CASP1 1 0.03 0.14 0.08
36 INT307666 Binding of Pmp22 and Gjb1 1 0.31 0.38 0.08
37 INT270829 P2rx7 Positive_regulation of Panx1 1 0.66 0.08 0.08
38 INT243253 Binding of Calb2 and Cfp 1 0.22 0.61 0.07
39 INT168976 Binding of Wt1 and Calb2 1 0.01 1.39 0.07
40 INT243258 Binding of Calb2 and Nefl 1 0.17 0.61 0.07
41 INT178084 EDNRA Positive_regulation of Phosphorylation of GJA1 1 0.10 0.88 0.06
42 INT178090 EDN1 Positive_regulation of Phosphorylation of GJA1 1 0.09 0.88 0.06
43 INT305876 ras Regulation of Regulation of Tjp2 1 0.00 0.39 0.04
44 INT217529 Dss1 Negative_regulation of Gene_expression of Tjp1 1 0.07 0.54 0.04
45 INT305883 Pcx Negative_regulation of Binding of Tjp1 1 0.04 0.11 0.04
46 INT221245 Binding of Gja3 and Gopc 1 0.01 0 0.03
47 INT266617 Binding of GJC1 and Tjp1 1 0.41 0.28 0.03
48 INT265345 Binding of Tgfbr1 and Tjp1 1 0.09 0.06 0.03
49 INT265343 Positive_regulation of Binding of Tgfbr1 and Tjp1 1 0.12 0.06 0.03
50 INT247821 Binding of Tjp1 and Gopc 1 0.03 0.4 0
51 INT260578 Binding of IGHG3 and SGSM3 1 0.00 1.07 0
52 INT355587 Binding of occludin and TJP1 1 0.01 1.12 0
53 INT305881 Positive_regulation of Binding of Ocln and Tjp1 1 0.01 0 0
54 INT270831 Positive_regulation of Panx1 Positive_regulation of NLRP3 1 0.18 0.1 0
55 INT247823 Binding of Cxadr and Tjp1 1 0.08 0.4 0
56 INT260577 Binding of ALPP and SGSM3 1 0.00 1.06 0
57 INT235019 Binding of DSC1 and DSP 1 0.39 0.07 0
58 INT305874 Binding of Pcx and Tjp1 1 0.03 0 0
59 INT247820 Gjc1 Regulation of Gja5 1 0.08 1.24 0
60 INT122536 FGF2 Positive_regulation of Positive_regulation of SGSM3 1 0.73 0 0
61 INT221233 Positive_regulation of Binding of Gja3 and Gfm1 1 0.00 0 0
62 INT221239 Binding of Gja3 and Gfm1 1 0.00 0 0
63 INT125019 Binding of S100A8 and TJP1 1 0.15 0.18 0
64 INT270836 CBX1 Negative_regulation of Panx1 1 0.09 0 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for gap junction. They are ordered first by their pain relevance and then by number of times they were reported in gap junction. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT46833 Positive_regulation of SGSM3 56 0.67 24.49 30.31
2 INT75521 Positive_regulation of Positive_regulation of SGSM3 13 0.67 7.99 13.54
3 INT10654 Negative_regulation of SGSM3 31 0.57 12.24 11.7
4 INT69867 Gene_expression of Mip 36 0.75 24.54 10.38
5 INT83292 Gene_expression of MIP 35 0.75 25.22 10.14
6 INT84894 Gene_expression of Calb2 45 0.73 24.65 7.81
7 INT87644 Phosphorylation of SGSM3 12 0.80 2.08 7.04
8 INT87775 Phosphorylation of Gja1 13 0.82 2.75 6.56
9 INT75250 Negative_regulation of Positive_regulation of SGSM3 5 0.57 2.47 5.24
10 INT75530 Regulation of SGSM3 11 0.60 7.22 4.48
11 INT134821 Gene_expression of Gja3 8 0.77 7.45 4.44
12 INT87780 Gene_expression of Gja1 22 0.77 5.84 4.24
13 INT38859 Gene_expression of SGSM3 14 0.75 12.98 4.09
14 INT85233 Localization of SGSM3 11 0.78 10.91 3.41
15 INT116078 Positive_regulation of Phosphorylation of SGSM3 4 0.67 0.09 3.24
16 INT85542 Negative_regulation of Calb2 5 0.38 5.4 3.18
17 INT38858 Positive_regulation of Gene_expression of SGSM3 5 0.49 4.15 3.05
18 INT98686 Gene_expression of Calb2 28 0.51 12.07 2.84
19 INT257683 Negative_regulation of Gene_expression of Gja3 1 0.58 2.63 2.78
20 INT82885 Gene_expression of Mip 7 0.65 7.89 2.76
21 INT86713 Positive_regulation of Mip 10 0.67 6.44 2.63
22 INT74046 Localization of Calb2 12 0.80 2.05 2.24
23 INT83294 Regulation of MIP 4 0.60 3.91 2.21
24 INT87778 Positive_regulation of Gene_expression of Gja1 6 0.69 1.46 2.14
25 INT149031 Gene_expression of Tjp1 43 0.75 19.1 2.06
26 INT83293 Negative_regulation of MIP 2 0.41 4.12 2.02
27 INT152771 Gene_expression of TJP1 19 0.75 14.95 1.98
28 INT87779 Positive_regulation of Gja1 4 0.53 0.9 1.95
29 INT82886 Positive_regulation of Mip 7 0.49 3.61 1.89
30 INT128030 Gene_expression of GJA1 23 0.75 7.81 1.88
31 INT87776 Positive_regulation of Phosphorylation of Gja1 3 0.62 0.71 1.86
32 INT15110 Regulation of Calb2 7 0.40 0.39 1.83
33 INT112971 Positive_regulation of Gene_expression of MIP 3 0.49 5.24 1.82
34 INT91336 Localization of MIP 5 0.78 2.97 1.79
35 INT83291 Regulation of Gene_expression of MIP 2 0.60 2 1.79
36 INT210590 Positive_regulation of Gene_expression of Mip 10 0.67 8.09 1.68
37 INT98662 Negative_regulation of Phosphorylation of SGSM3 2 0.57 0.52 1.58
38 INT45390 Negative_regulation of Mip 2 0.20 0.21 1.41
39 INT69863 Binding of Mip 7 0.36 4.54 1.33
40 INT32101 Regulation of Mip 3 0.26 0.89 1.31
41 INT192982 Binding of Calb2 8 0.33 1.61 1.22
42 INT2683 Binding of SGSM3 6 0.36 7.98 1.2
43 INT85402 Transcription of Calb2 4 0.61 2.73 1.17
44 INT289973 Negative_regulation of Gene_expression of MIP 2 0.41 2.69 1.15
45 INT268763 Negative_regulation of Mip 3 0.41 2.61 1.12
46 INT238495 Negative_regulation of Gene_expression of TJP1 5 0.18 9.51 1.05
47 INT134822 Gene_expression of Gja1 18 0.72 4.2 1
48 INT101050 Localization of Mip 4 0.78 1.9 0.93
49 INT257685 Regulation of Gene_expression of Gja3 1 0.61 2.86 0.91
50 INT217506 Gene_expression of Tjp2 8 0.32 5.26 0.89
51 INT98175 Regulation of Regulation of SGSM3 1 0.44 0.87 0.81
52 INT87777 Regulation of Gja1 1 0.62 0.76 0.81
53 INT85234 Regulation of Negative_regulation of SGSM3 1 0.26 1.13 0.79
54 INT143306 Positive_regulation of Gja1 3 0.50 0.42 0.75
55 INT178116 Phosphorylation of GJA1 7 0.80 4.09 0.74
56 INT128402 Negative_regulation of Phosphorylation of Gja1 1 0.58 0.73 0.73
57 INT152909 Regulation of Gene_expression of Gja1 1 0.61 0.46 0.69
58 INT87445 Localization of TJP1 2 0.45 0.55 0.68
59 INT221216 Localization of Gja3 12 0.65 3.65 0.67
60 INT152775 Regulation of Gene_expression of TJP1 1 0.44 2.05 0.67
61 INT87781 Regulation of Phosphorylation of Gja1 1 0.27 0 0.67
62 INT334126 Positive_regulation of Positive_regulation of Mip 1 0.20 1.65 0.67
63 INT246207 Positive_regulation of GJA1 3 0.67 0.91 0.65
64 INT134819 Positive_regulation of Gene_expression of Gja3 3 0.50 1.68 0.63
65 INT159141 Negative_regulation of Gene_expression of Tjp1 7 0.57 5.44 0.62
66 INT98660 Positive_regulation of Localization of SGSM3 2 0.45 1.67 0.62
67 INT79432 Positive_regulation of Calb2 7 0.23 6.59 0.61
68 INT173793 Positive_regulation of Gja3 6 0.50 0.55 0.6
69 INT91332 Regulation of Localization of MIP 1 0.44 0.75 0.6
70 INT163777 Negative_regulation of Gene_expression of Calb2 2 0.34 1.39 0.58
71 INT165816 Gene_expression of Gjb1 1 0.65 0.68 0.57
72 INT221197 Phosphorylation of Gja3 3 0.71 0.99 0.56
73 INT210075 Positive_regulation of MIP 3 0.67 0.98 0.56
74 INT165817 Negative_regulation of Gjb1 1 0.36 0.72 0.56
75 INT270809 Gene_expression of Panx1 1 0.69 0.59 0.55
76 INT154837 Regulation of Gja1 2 0.45 1.42 0.53
77 INT268755 Negative_regulation of Gene_expression of Mip 1 0.41 1.73 0.51
78 INT159140 Positive_regulation of Gene_expression of Tjp1 11 0.61 5.04 0.5
79 INT257688 Negative_regulation of Gja3 1 0.58 1.15 0.5
80 INT101365 Binding of Tjp1 8 0.11 1.66 0.49
81 INT134820 Positive_regulation of Gene_expression of Gja1 3 0.64 0.84 0.49
82 INT87774 Binding of Gja1 2 0.48 0.19 0.48
83 INT329831 Positive_regulation of Positive_regulation of GJA1 1 0.49 0.58 0.48
84 INT248207 Positive_regulation of Calb2 3 0.20 0.49 0.46
85 INT159146 Regulation of Gene_expression of Tjp1 13 0.44 6.91 0.45
86 INT192937 Positive_regulation of Gene_expression of GJA1 4 0.67 0.4 0.44
87 INT183187 Transcription of Mip 2 0.69 0.69 0.43
88 INT221202 Binding of Gja3 3 0.32 1.18 0.42
89 INT335992 Protein_catabolism of MIP 1 0.86 1.04 0.42
90 INT268751 Positive_regulation of Binding of Mip 1 0.49 0.91 0.4
91 INT138976 Binding of Mip 3 0.30 0.17 0.39
92 INT270810 Localization of Panx1 1 0.67 0.33 0.34
93 INT124634 Binding of MIP 2 0.35 0.46 0.31
94 INT302362 Positive_regulation of Positive_regulation of Calb2 1 0.11 0.12 0.3
95 INT217501 Positive_regulation of Tjp1 8 0.49 2.91 0.28
96 INT302358 Positive_regulation of Gene_expression of Calb2 1 0.12 0.11 0.27
97 INT270811 Negative_regulation of Panx1 1 0.52 0.4 0.27
98 INT132951 Regulation of GJA1 2 0.57 0.79 0.24
99 INT217504 Regulation of Tjp1 9 0.32 2.44 0.23
100 INT247021 Binding of GJA1 6 0.47 0.91 0.23
101 INT268762 Positive_regulation of Localization of Mip 1 0.49 0.83 0.23
102 INT126761 Negative_regulation of Gja1 1 0.33 0.08 0.22
103 INT221194 Negative_regulation of Phosphorylation of Gja3 1 0.11 0.62 0.22
104 INT221204 Positive_regulation of Localization of Gja3 1 0.13 0.62 0.21
105 INT183186 Regulation of Mip 4 0.26 1.26 0.2
106 INT268749 Regulation of Gene_expression of Mip 1 0.44 0.41 0.2
107 INT98661 Negative_regulation of Localization of SGSM3 1 0.41 0.52 0.2
108 INT270812 Transcription of Panx1 1 0.54 0.26 0.19
109 INT270803 Negative_regulation of Transcription of Panx1 1 0.33 0.26 0.19
110 INT186146 Negative_regulation of GJA1 2 0.41 1.29 0.18
111 INT178124 Positive_regulation of Phosphorylation of GJA1 2 0.65 1.21 0.18
112 INT268758 Regulation of Positive_regulation of Mip 1 0.44 0.83 0.18
113 INT217505 Positive_regulation of Tjp2 1 0.28 1.69 0.18
114 INT308526 Protein_catabolism of TJP1 1 0.07 1.18 0.17
115 INT268756 Negative_regulation of Positive_regulation of Mip 1 0.41 0.83 0.17
116 INT318208 Transcription of TJP1 1 0.02 0.38 0.17
117 INT285900 Positive_regulation of Localization of MIP 1 0.49 1.09 0.17
118 INT318193 Transcription of Tjp2 1 0.02 0.38 0.17
119 INT308525 Protein_catabolism of Tjp2 1 0.08 1.24 0.17
120 INT122708 Localization of Mip 2 0.61 0.17 0.16
121 INT190974 Regulation of Gene_expression of Calb2 2 0.29 0.36 0.16
122 INT159727 Binding of Calb2 3 0.29 2.28 0.15
123 INT209185 Regulation of Phosphorylation of GJA1 2 0.44 0.09 0.14
124 INT217507 Localization of Tjp1 5 0.57 1.65 0.13
125 INT149030 Phosphorylation of Tjp1 4 0.58 0.96 0.13
126 INT217519 Regulation of Tjp2 3 0.18 1.45 0.12
127 INT101051 Regulation of Localization of Mip 1 0.19 0.09 0.11
128 INT142767 Regulation of Gene_expression of Calb2 1 0.18 0.55 0.11
129 INT142766 Regulation of Calb2 1 0.18 0.55 0.11
130 INT157782 Regulation of Gja3 4 0.44 1.24 0.1
131 INT189876 Binding of TJP1 3 0.14 0.29 0.1
132 INT155667 Negative_regulation of Gene_expression of Gja1 3 0.42 1.16 0.1
133 INT217520 Negative_regulation of Positive_regulation of Tjp2 1 0.17 0.43 0.1
134 INT209182 Regulation of Gene_expression of GJA1 1 0.57 0.09 0.09
135 INT217522 Transcription of Tjp1 1 0.38 0.91 0.09
136 INT268748 Phosphorylation of Mip 1 0.79 0.08 0.08
137 INT270808 Positive_regulation of Gene_expression of Panx1 1 0.62 0.13 0.08
138 INT109652 Negative_regulation of Tjp1 3 0.32 0.92 0.07
139 INT188177 Localization of GJA1 2 0.75 0.07 0.07
140 INT178132 Negative_regulation of Gene_expression of GJA1 2 0.35 0.84 0.07
141 INT209187 Positive_regulation of Localization of GJA1 1 0.65 0.07 0.07
142 INT247799 Gene_expression of Gja5 1 0.34 0.74 0.07
143 INT247810 Negative_regulation of Gene_expression of Gja5 1 0.26 0.74 0.07
144 INT217508 Negative_regulation of Phosphorylation of Tjp1 1 0.30 0.77 0.07
145 INT270807 Positive_regulation of Localization of Panx1 1 0.39 0.05 0.06
146 INT247816 Localization of Gja5 1 0.41 0.74 0.05
147 INT257689 Negative_regulation of Gja1 1 0.37 0.58 0.05
148 INT221199 Positive_regulation of Positive_regulation of Gja3 1 0.13 0.08 0.05
149 INT228786 Regulation of Gene_expression of Gja1 2 0.29 0.49 0.04
150 INT305869 Binding of Tjp2 1 0.04 0.31 0.04
151 INT270806 Positive_regulation of Panx1 1 0.62 0.3 0.04
152 INT190967 Positive_regulation of Gene_expression of Calb2 1 0.08 0 0.04
153 INT228802 Negative_regulation of Gene_expression of Gja1 4 0.37 0.87 0.03
154 INT216569 Localization of Gja1 2 0.36 0.35 0.03
155 INT154990 Negative_regulation of TJP1 2 0.20 1.74 0.03
156 INT260582 Transcription of SGSM3 1 0.05 1.55 0.03
157 INT270801 Binding of Panx1 1 0.33 0 0.03
158 INT247800 Regulation of Gja5 1 0.23 2.48 0.03
159 INT238493 Positive_regulation of Gene_expression of TJP1 1 0.16 2.08 0.03
160 INT217521 Positive_regulation of Positive_regulation of Tjp1 1 0.35 0.66 0.03
161 INT257682 Negative_regulation of Localization of Gja3 1 0.37 0.09 0.03
162 INT265315 Positive_regulation of Binding of Tjp1 3 0.11 0.3 0
163 INT247813 Localization of Gja1 2 0.45 0.47 0
164 INT334169 Localization of Calb2 2 0.40 0 0
165 INT247793 Regulation of Localization of Gja1 2 0.17 0.47 0
166 INT276270 Positive_regulation of Binding of MIP 1 0.16 0 0
167 INT149029 Positive_regulation of Negative_regulation of Tjp1 1 0.36 0 0
168 INT128359 Positive_regulation of Negative_regulation of SGSM3 1 0.45 0 0
169 INT209190 Negative_regulation of Negative_regulation of GJA1 1 0.40 0 0
170 INT119082 Negative_regulation of Gene_expression of SGSM3 1 0.41 0 0
171 INT217518 Positive_regulation of Positive_regulation of Tjp2 1 0.19 0.44 0
172 INT217512 Negative_regulation of Gene_expression of Tjp2 1 0.17 0.34 0
173 INT178112 Negative_regulation of Phosphorylation of GJA1 1 0.18 1.09 0
174 INT154991 Positive_regulation of Negative_regulation of TJP1 1 0.17 0.06 0
175 INT157781 Transcription of Gja3 1 0.67 0 0
176 INT299204 Transcription of Mip 1 0.21 0.62 0
177 INT270805 Positive_regulation of Positive_regulation of Panx1 1 0.45 0.13 0
178 INT247817 Positive_regulation of Gja5 1 0.24 0.32 0
179 INT234941 Gene_expression of DSC1 1 0.28 0.67 0
180 INT247797 Gene_expression of Gjc1 1 0.37 1.93 0
181 INT234948 Negative_regulation of DSC1 1 0.07 0.07 0
182 INT270799 Negative_regulation of Positive_regulation of Panx1 1 0.33 0 0
183 INT217509 Positive_regulation of Regulation of Tjp1 1 0.35 0.12 0
184 INT149033 Positive_regulation of Phosphorylation of Tjp1 1 0.34 0 0
185 INT265332 Regulation of Binding of Tjp1 1 0.05 0 0
186 INT247804 Negative_regulation of Gene_expression of Gjc1 1 0.28 1.6 0
187 INT265321 Negative_regulation of Binding of Tjp1 1 0.08 0.17 0
188 INT247801 Regulation of Gjc1 1 0.21 1.24 0
189 INT305867 Regulation of Localization of Tjp1 1 0.08 0 0
190 INT270802 Negative_regulation of Gene_expression of Panx1 1 0.33 0 0
191 INT270804 Regulation of Panx1 1 0.35 0.06 0
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