GO:0005925

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Name focal adhesion
Categary Component
Go Slim No
Go Link GO:0005925
Unique Molecular Interactions 1339
Total Molecular Interactions 1826
Total Single Events 14761
Pain Genes Associated 110

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for focal adhesion. They are ordered first by their pain relevance and then by number of times they were reported for focal adhesion. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT259233 Binding of Oprm1 and Flna 1 0.03 0.25 25.89
2 INT259228 Binding of Oprm1 and Glul 1 0.00 0.08 7.22
3 INT40114 Binding of OPRD1 and Oprm1 2 0.00 0 4.29
4 INT259230 Negative_regulation of Binding of Oprm1 and Flna 1 0.02 0 4.15
5 INT317511 Ppp1r9b Regulation of Oprm1 3 0.27 0.33 3.85
6 INT317517 Binding of Nos1 and Oprm1 1 0.17 0.22 3.85
7 INT180813 Ngf Positive_regulation of Sorbs1 1 0.04 2.09 3.79
8 INT18026 Binding of Oprd1 and Oprm1 4 0.40 0.83 3.53
9 INT302118 Binding of Oprm1 and Ppp1r9b 2 0.24 0.26 3.45
10 INT137918 Oprm1 Positive_regulation of Pdgfrb 1 0.41 0 3.31
11 INT108810 Esr1 Positive_regulation of Binding of Oprm1 1 0.51 1.79 3.22
12 INT317563 Binding of Hint1 and Oprm1 1 0.20 0.25 3.03
13 INT106837 Binding of Oprm1 and Arrb2 3 0.32 0.83 3.01
14 INT317551 Binding of Akt1 and Oprm1 1 0.19 0.21 2.74
15 INT114134 Penk Positive_regulation of Oprm1 2 0.24 1.48 2.68
16 INT259231 Binding of Oprm1 and Ppp1r9b 1 0.01 0 2.67
17 INT42727 Binding of Oprm1 and Trim13 1 0.14 0 2.54
18 INT238914 Positive_regulation of CNR1 Positive_regulation of Phosphorylation of MAPK1 1 0.19 3.22 2.35
19 INT96461 Pnoc Positive_regulation of Oprm1 1 0.09 0.73 2.34
20 INT154226 Positive_regulation of Oprk1 Negative_regulation of Negative_regulation of Oprm1 1 0.28 0.07 2.32
21 INT134583 Arrb2 Regulation of Oprm1 1 0.41 1.23 2.15
22 INT64750 Binding of Oprm1 and Pck1 2 0.41 0.51 2.07
23 INT114927 Positive_regulation of Binding of Oprm1 and Creb1 1 0.17 0.28 2.07
24 INT114923 Binding of Oprm1 and Creb1 1 0.16 0.28 2.06
25 INT137917 Oprm1 Positive_regulation of Kdr 1 0.43 0 1.98
26 INT317540 Camk2a Negative_regulation of Oprm1 1 0.19 0 1.98
27 INT146099 Binding of Oprm1 and Rgs9 1 0.48 0 1.95
28 INT107738 Binding of Pld2 and Oprm1 1 0.23 0 1.93
29 INT65025 Binding of Oprm1 and Hps4 1 0.01 0 1.93
30 INT169498 Binding of Oprm1 and Mirlet7a-1 1 0.32 0 1.9
31 INT151965 SORBS1 Positive_regulation of TRPV1 1 0.18 0 1.89
32 INT153582 Binding of Oprm1 and Hint1 1 0.01 0 1.87
33 INT211747 Negative_regulation of Binding of Oprm1 and Mors1 1 0.09 0 1.86
34 INT29996 Binding of Oprm1 and Penk 2 0.36 0.4 1.85
35 INT199486 Oprm1 Regulation of Gene_expression of Oprd1 1 0.02 0.49 1.84
36 INT169502 Mirlet7a-1 Regulation of Oprm1 1 0.53 0 1.81
37 INT199287 TNF Positive_regulation of Transcription of Oprm1 2 0.02 1.86 1.8
38 INT168925 Binding of Oprm1 and Imraq2 1 0.04 0.13 1.78
39 INT168924 Positive_regulation of Binding of Oprm1 and Imraq2 1 0.06 0.13 1.78
40 INT211746 Binding of Oprm1 and Mors1 1 0.08 0 1.78
41 INT6407 Binding of Lama5 and Oprm1 1 0.02 0.08 1.72
42 INT200335 Binding of Oprm1 and Rest 1 0.40 0.07 1.7
43 INT199504 ENG Positive_regulation of Oprm1 1 0.01 0.87 1.68
44 INT149680 Binding of Parp1 and Oprm1 1 0.53 0 1.66
45 INT96296 Oprm1 Negative_regulation of Npr1 2 0.05 0.32 1.65
46 INT315180 Gene_expression of Mors1 Positive_regulation of Gene_expression of Oprm1 1 0.03 0.48 1.64
47 INT315181 Gene_expression of Mors1 Positive_regulation of Oprm1 1 0.03 0.48 1.64
48 INT90046 Oprm1 Positive_regulation of P9Ehs1 2 0.16 0.92 1.63
49 INT199501 Pdyn Positive_regulation of Oprm1 1 0.01 0.86 1.63
50 INT109525 Binding of DMRT1 and Oprm1 1 0.08 0 1.62
51 INT180812 Gdnf Positive_regulation of Gene_expression of Sorbs1 1 0.02 0.83 1.61
52 INT180811 Gdnf Positive_regulation of Regulation of Sorbs1 1 0.01 0.83 1.61
53 INT140341 Ngf Positive_regulation of Gene_expression of Oprm1 1 0.02 0.33 1.59
54 INT317558 Binding of Oprm1 and Rgs17 1 0.18 0 1.59
55 INT168609 Binding of Itgb1 and Mmp9 1 0.02 0.41 1.58
56 INT12327 Igh-Dex Positive_regulation of Plec 1 0.03 0.73 1.57
57 INT144280 ACP1 Negative_regulation of Phosphorylation of MAPK1 1 0.37 0.78 1.56
58 INT114926 Creb1 Negative_regulation of Positive_regulation of Oprm1 1 0.13 0.23 1.56
59 INT148821 Binding of Oprm1 and Grin1 1 0.05 0.24 1.55
60 INT148820 Binding of Oprm1 and Naa15 1 0.02 0.24 1.55
61 INT111828 UPB1 Positive_regulation of Oprm1 1 0.00 0.85 1.53
62 INT72666 Binding of ODT and Oprm1 1 0.03 0.53 1.5
63 INT45502 TNS1 Positive_regulation of VIP 1 0.47 0.52 1.5
64 INT117008 Sfpi1 Regulation of Oprm1 1 0.56 0.56 1.49
65 INT8735 Oprm1 Positive_regulation of Scn4a 1 0.00 0 1.49
66 INT155497 Oprk1 Negative_regulation of Tenc1 1 0.08 0.34 1.48
67 INT40209 TNS3 Regulation of POMC 1 0.16 0.27 1.47
68 INT317509 Oprm1 Negative_regulation of Phosphorylation of Oprd1 1 0.00 0 1.46
69 INT141673 Oprm1 Positive_regulation of Negative_regulation of Ltp 1 0.13 0 1.46
70 INT141674 Oprm1 Positive_regulation of Ltp 1 0.13 0 1.46
71 INT131039 Binding of Oprm1 and Prf1 1 0.17 0 1.45
72 INT131041 Negative_regulation of Binding of Oprm1 and Prf1 1 0.21 0 1.45
73 INT131040 Binding of Oprm1 and S100a9 1 0.24 0 1.45
74 INT153581 Binding of Oprm1 and Prkcg 1 0.00 0 1.44
75 INT180804 Bdnf Positive_regulation of Gene_expression of Sorbs1 1 0.01 0 1.44
76 INT69337 Oprm1 Positive_regulation of Atxn2l 1 0.01 0.27 1.43
77 INT125856 Positive_regulation of Oprm1 Regulation of Positive_regulation of Insrr 1 0.01 0.26 1.43
78 INT43814 Binding of Cpe and Oprm1 1 0.08 0 1.41
79 INT142852 Oprm1 Positive_regulation of Oprd1 1 0.41 0.06 1.41
80 INT180809 Ngf Positive_regulation of Positive_regulation of Sorbs1 1 0.03 0.84 1.4
81 INT180808 Ngf Positive_regulation of Gene_expression of Sorbs1 1 0.03 0.84 1.4
82 INT259232 Binding of Flna and Positive_regulation of Localization of Oprm1 1 0.03 0 1.39
83 INT139987 Oprm1 Positive_regulation of Localization of Oprl1 1 0.16 0.17 1.35
84 INT106062 Positive_regulation of Oprl1 Positive_regulation of Mapk1 1 0.13 0.16 1.35
85 INT106071 Positive_regulation of Oprl1 Positive_regulation of MAPK3 1 0.12 0.16 1.34
86 INT180802 Gdnf Positive_regulation of Sorbs1 1 0.02 0.98 1.34
87 INT106839 Arrb2 Regulation of Oprm1 2 0.21 0.44 1.33
88 INT180807 Calca Regulation of Sorbs1 1 0.02 0 1.32
89 INT38624 Binding of Oprm1 and Insrr 2 0.01 0.24 1.31
90 INT317519 Grin1 Positive_regulation of Negative_regulation of Oprm1 1 0.14 0 1.31
91 INT130786 Positive_regulation of Oprm1 Positive_regulation of Arc 1 0.27 0.9 1.31
92 INT168229 Oprm1 Regulation of Cea 1 0.10 0.26 1.3
93 INT128310 Oprm1 Positive_regulation of Oprm1 1 0.00 0.1 1.29
94 INT89943 Binding of Oprm1 and Il2 1 0.03 0.53 1.28
95 INT114929 Positive_regulation of Binding of Oprm1 and Crebbp 1 0.06 0.14 1.28
96 INT64749 Negative_regulation of Binding of Oprm1 and Pck1 1 0.47 0.21 1.27
97 INT114925 Binding of Oprm1 and Crebbp 1 0.06 0.14 1.27
98 INT124767 Creb1 Regulation of Oprm1 1 0.45 0 1.26
99 INT207548 U Negative_regulation of Gene_expression of Oprm1 1 0.01 0.46 1.26
100 INT121464 Negative_regulation of Oprm1 Positive_regulation of Dnm2 1 0.34 0 1.26
101 INT87375 Binding of Gabrg1 and Oprm1 1 0.00 0.83 1.25
102 INT126801 Regulation of Binding of Oprm1 and Penk 1 0.34 0.4 1.25
103 INT151444 Binding of Oprm1 and Pag1 1 0.00 1.5 1.24
104 INT121465 Binding of Dnm2 and Oprm1 1 0.23 0 1.24
105 INT125857 Insrr Negative_regulation of Oprm1 1 0.01 0.27 1.24
106 INT92800 Arrb2 Negative_regulation of Oprm1 1 0.37 0.33 1.24
107 INT259229 Positive_regulation of Binding of Oprm1 and Flna 1 0.02 0 1.23
108 INT58140 Binding of AP2M1 and Oprm1 1 0.01 0.4 1.23
109 INT76165 IGKV2-30 Positive_regulation of Phosphorylation of Oprm1 1 0.00 0.08 1.22
110 INT75229 Prkaca Positive_regulation of Phosphorylation of Oprm1 1 0.44 0 1.22
111 INT76163 Prkaca Positive_regulation of Phosphorylation of Oprm1 1 0.02 0.08 1.22
112 INT124157 Oprm1 Negative_regulation of Gnb5 1 0.25 0.4 1.19
113 INT139736 Htr1a Positive_regulation of Mapk3 1 0.54 0.13 1.19
114 INT133496 Binding of Oprm1 and Cckbr 1 0.15 0 1.19
115 INT121191 KCNMA1 Positive_regulation of Phosphorylation of MAPK1 1 0.06 0.61 1.18
116 INT153589 Binding of PRKCI and Oprm1 1 0.06 0 1.17
117 INT153588 Binding of HINT1 and Oprm1 1 0.06 0 1.17
118 INT238916 CNR1 Positive_regulation of Phosphorylation of MAPK1 1 0.19 1.61 1.17
119 INT200312 Rest Regulation of Oprm1 1 0.23 0.27 1.16
120 INT117082 TNS3 Regulation of Ssr1 1 0.05 0 1.16
121 INT88778 Binding of Oprm1 and Pomc 3 0.21 0.56 1.14
122 INT317549 Negative_regulation of Camk2a Negative_regulation of Phosphorylation of Oprm1 1 0.19 0 1.14
123 INT68157 Alox5 Positive_regulation of Positive_regulation of Pdpk1 1 0.01 0.64 1.13
124 INT68154 Mthfs Positive_regulation of Pdpk1 1 0.01 0.63 1.12
125 INT110522 Oprm1 Positive_regulation of Oprk1 1 0.11 0 1.12
126 INT68158 Pla2g1b Positive_regulation of Pdpk1 1 0.05 0.63 1.12
127 INT68159 Pla2g1b Positive_regulation of Positive_regulation of Pdpk1 1 0.05 0.64 1.12
128 INT68163 Mthfs Positive_regulation of Positive_regulation of Pdpk1 1 0.01 0.64 1.12
129 INT68165 Alox5 Positive_regulation of Pdpk1 1 0.01 0.63 1.12
130 INT317516 Binding of Oprm1 and Negative_regulation of Positive_regulation of Akt1 1 0.17 0.1 1.11
131 INT69338 Binding of Oprd1 and Oprm1 1 0.24 0.26 1.11
132 INT99691 Pdpk1 Positive_regulation of Positive_regulation of VEGFA 1 0.01 0.72 1.11
133 INT133497 Binding of Oprm1 and Cckbr 1 0.03 0 1.1
134 INT317512 Binding of Oprm1 and Prkca 1 0.07 0.13 1.1
135 INT142413 Oprm1 Positive_regulation of Gdnf 1 0.19 0.29 1.09
136 INT114007 Binding of Crygs and Oprm1 1 0.03 0 1.09
137 INT164378 MAPK3 Positive_regulation of Transcription of PDYN 1 0.50 0.2 1.09
138 INT164382 MAPK3 Positive_regulation of Gene_expression of Fos 1 0.75 0.2 1.08
139 INT164383 Positive_regulation of MAPK3 Positive_regulation of Gene_expression of Fos 1 0.54 0.2 1.08
140 INT317561 Binding of Grin1 and Oprm1 1 0.14 0.09 1.08
141 INT81582 Plec Positive_regulation of st 1 0.02 0 1.07
142 INT81581 Plec Positive_regulation of Nudt14 1 0.01 0 1.07
143 INT181493 TRPV4 Regulation of Gene_expression of NGF 1 0.24 0.7 1.07
144 INT77982 Binding of YY1 and Oprm1 2 0.17 0.17 1.06
145 INT73311 Binding of Oprm1 and Pdpn 1 0.08 0.71 1.06
146 INT145906 Elane Regulation of Transcription of Oprm1 1 0.10 0.14 1.04
147 INT180806 Ngf Positive_regulation of Regulation of Sorbs1 1 0.03 0.28 1.04
148 INT101067 MAP3K15 Positive_regulation of MAPK1 1 0.21 0.47 1.03
149 INT150621 Binding of Oprm1 and Oprd1 1 0.00 0.08 1.02
150 INT98555 Oprm1 Positive_regulation of Casp8 1 0.51 0.36 1.02
151 INT263232 Prkcg Positive_regulation of Trpv4 1 0.12 1.1 1.02
152 INT106956 Oprm1 Positive_regulation of Positive_regulation of P9Ehs1 1 0.08 0.54 1.02
153 INT229914 Egr1 Positive_regulation of Phosphorylation of Mapk3 1 0.46 1.03 1.02
154 INT116751 Positive_regulation of Oprm1 Positive_regulation of Pik3cd 1 0.28 0.38 1.01
155 INT98556 Oprm1 Positive_regulation of Casp3 1 0.38 0.36 1.01
156 INT98002 Positive_regulation of Oprm1 Positive_regulation of P9Ehs1 1 0.10 0 1
157 INT317554 Akt1 Regulation of Negative_regulation of Oprm1 1 0.21 0.07 1
158 INT317532 Grin1 Regulation of Negative_regulation of Oprm1 1 0.18 0.07 1
159 INT70105 SCD Positive_regulation of Oprm1 1 0.01 0 1
160 INT317518 Src Regulation of Negative_regulation of Oprm1 1 0.16 0.07 1
161 INT317555 Nos1 Regulation of Negative_regulation of Oprm1 1 0.21 0.07 1
162 INT263227 Positive_regulation of Prkcg Regulation of Trpv4 1 0.07 0.95 1
163 INT317544 Camk2a Regulation of Negative_regulation of Oprm1 1 0.20 0.07 1
164 INT317564 Pik3r1 Regulation of Negative_regulation of Oprm1 1 0.13 0.07 1
165 INT317568 Prkca Regulation of Negative_regulation of Oprm1 1 0.10 0.07 1
166 INT169500 Negative_regulation of Mirlet7a-1 Regulation of Oprm1 1 0.37 0 0.99
167 INT200323 Binding of Oprm1 and Sp3 1 0.39 0 0.99
168 INT94989 Arrb2 Regulation of Regulation of Oprm1 1 0.24 0 0.98
169 INT140652 IGF1 Positive_regulation of Phosphorylation of MAPK1 1 0.26 0.63 0.98
170 INT57555 Binding of Oprm1 and Oprl1 2 0.06 0.05 0.97
171 INT133616 Map2k1 Regulation of Fadd 1 0.04 0.29 0.97
172 INT133614 Map2k1 Regulation of Daxx 1 0.02 0.29 0.97
173 INT133615 Regulation of Map2k1 Regulation of Fadd 1 0.04 0.29 0.97
174 INT137920 Binding of Kdr and Oprm1 1 0.23 0 0.97
175 INT346204 Binding of S100A10 and TPPP 1 0.02 1.62 0.97
176 INT317543 Pag1 Positive_regulation of Oprm1 1 0.12 0.73 0.97
177 INT137919 Binding of Oprm1 and Stat3 1 0.30 0 0.97
178 INT83415 Binding of Oprm1 and Ntrk1 1 0.01 0 0.96
179 INT253836 Cck Regulation of DST 1 0.03 0.42 0.95
180 INT180803 Sorbs1 Regulation of Gdnf 1 0.01 0.28 0.95
181 INT100018 TNF Positive_regulation of MAPK1 3 0.24 1.56 0.94
182 INT137922 VEGFA Positive_regulation of Oprm1 1 0.06 0 0.94
183 INT144281 ACP1 Negative_regulation of Positive_regulation of MAPK1 1 0.27 0.58 0.94
184 INT117005 Sfpi1 Positive_regulation of Oprm1 1 0.52 0.56 0.94
185 INT146096 Positive_regulation of Binding of Oprm1 and Rgs9 1 0.44 0 0.94
186 INT144285 ACP1 Negative_regulation of MAPK1 1 0.37 0.58 0.93
187 INT65024 Binding of Oprm1 and Penk 1 0.03 0 0.93
188 INT116930 OPRK1 Positive_regulation of Binding of PTK2 1 0.28 0.35 0.93
189 INT107335 Pdpk1 Positive_regulation of Regulation of Sigmar1 1 0.02 0 0.93
190 INT79123 Binding of Pnoc and Oprm1 3 0.14 0 0.91
191 INT149386 Binding of Lyn and TRPV4 1 0.40 1.14 0.91
192 INT135446 Map2k1 Positive_regulation of Mapk3 1 0.54 0.25 0.91
193 INT343918 IgG Positive_regulation of Phosphorylation of MAPK1 1 0.01 3.57 0.91
194 INT317530 Negative_regulation of Binding of Nos1 and Oprm1 1 0.21 0.06 0.9
195 INT54854 Sorbs1 Regulation of Ins1 1 0.34 0.23 0.9
196 INT61046 Oprm1 Positive_regulation of Gh1 1 0.21 0 0.89
197 INT83417 Binding of OPRL1 and Oprm1 1 0.01 0 0.89
198 INT97184 Oprm1 Regulation of Gene_expression of Pomc 1 0.31 0 0.89
199 INT61047 Oprm1 Positive_regulation of Localization of Gh1 1 0.29 0 0.89
200 INT61048 Oprm1 Positive_regulation of Localization of Prl 1 0.16 0 0.88

Single Events

The table below shows the top 100 pain related interactions that have been reported for focal adhesion. They are ordered first by their pain relevance and then by number of times they were reported in focal adhesion. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT5895 Gene_expression of Oprm1 525 0.78 120.67 407.29
2 INT5540 Positive_regulation of Oprm1 344 0.70 76.77 319.71
3 INT6406 Binding of Oprm1 280 0.48 40.54 226.26
4 INT6293 Gene_expression of Oprm1 312 0.78 48.73 215.61
5 INT12602 Negative_regulation of Oprm1 190 0.59 36.11 177.85
6 INT26472 Regulation of Oprm1 191 0.62 35.84 173.1
7 INT5930 Positive_regulation of Oprm1 221 0.70 31.19 172.93
8 INT6042 Binding of Oprm1 248 0.48 31.77 154.34
9 INT5931 Regulation of Oprm1 149 0.62 18.15 125.93
10 INT5906 Negative_regulation of Oprm1 125 0.59 19.58 101.57
11 INT71789 Positive_regulation of MAPK1 396 0.70 234.44 89.27
12 INT8733 Localization of Oprm1 61 0.75 7.55 64.61
13 INT48934 Positive_regulation of Mapk1 157 0.70 60.61 61.72
14 INT8732 Positive_regulation of Gene_expression of Oprm1 76 0.70 22.59 58.83
15 INT68813 Transcription of Oprm1 93 0.71 20.11 57.65
16 INT49747 Transcription of Oprm1 68 0.72 9.01 53.78
17 INT1232 Positive_regulation of Pdpk1 78 0.42 24.33 50.17
18 INT62521 Phosphorylation of Oprm1 44 0.82 2.66 47.45
19 INT71786 Phosphorylation of MAPK1 256 0.82 110.09 46.17
20 INT18992 Negative_regulation of Pdpk1 53 0.42 19.02 40.95
21 INT48933 Gene_expression of Mapk3 93 0.75 44.39 37.92
22 INT88081 Negative_regulation of Gene_expression of Oprm1 45 0.59 16.56 37.5
23 INT14137 Localization of Oprm1 56 0.81 2.88 36.09
24 INT109434 Phosphorylation of Mapk1 110 0.82 61.64 34.05
25 INT48924 Positive_regulation of Mapk3 107 0.67 50.53 34.05
26 INT48907 Positive_regulation of Gene_expression of Oprm1 53 0.69 8.55 33.52
27 INT109820 Gene_expression of Trpv4 121 0.78 39.69 33.11
28 INT21560 Positive_regulation of Binding of Oprm1 30 0.50 7.16 32.95
29 INT48925 Gene_expression of Mapk1 95 0.74 42.21 32.91
30 INT72375 Phosphorylation of Mapk3 87 0.80 43.66 30.27
31 INT16769 Positive_regulation of Positive_regulation of Oprm1 31 0.57 8.29 29.66
32 INT83708 Negative_regulation of MAPK1 156 0.57 84.93 27.85
33 INT72677 Regulation of Gene_expression of Oprm1 45 0.62 13.95 26.75
34 INT12124 Gene_expression of MAPK1 141 0.75 82.4 25.58
35 INT71781 Phosphorylation of MAPK3 62 0.80 27.73 23.73
36 INT6294 Regulation of Gene_expression of Oprm1 28 0.62 6.77 22.79
37 INT57253 Negative_regulation of Binding of Oprm1 24 0.43 5.27 22.67
38 INT48769 Regulation of Pdpk1 20 0.35 9.78 20.36
39 INT49835 Negative_regulation of Positive_regulation of Oprm1 21 0.42 4.11 20.11
40 INT112174 Gene_expression of Trpv4 47 0.78 26.26 20.09
41 INT21105 Phosphorylation of Oprm1 32 0.82 0.83 19.29
42 INT91462 Positive_regulation of Phosphorylation of MAPK1 99 0.67 40.28 18.99
43 INT71787 Positive_regulation of MAPK3 37 0.67 17.5 17.88
44 INT58495 Positive_regulation of Positive_regulation of Oprm1 22 0.49 2.44 17.66
45 INT119233 Positive_regulation of Trpv4 65 0.70 20.21 17.3
46 INT26972 Negative_regulation of Tenc1 57 0.57 56.71 16.87
47 INT6043 Negative_regulation of Binding of Oprm1 24 0.57 2.67 16.78
48 INT33915 Regulation of Positive_regulation of Oprm1 22 0.60 2.44 16.43
49 INT75531 Regulation of MAPK1 70 0.61 34.39 15.42
50 INT128401 Positive_regulation of Positive_regulation of Mapk1 39 0.70 10.88 15.38
51 INT68811 Regulation of Transcription of Oprm1 19 0.61 3.67 15.15
52 INT12658 Regulation of Binding of Oprm1 9 0.57 2.44 14.95
53 INT80688 Positive_regulation of Positive_regulation of MAPK1 72 0.69 39.35 14.11
54 INT26733 Gene_expression of Pdpk1 17 0.48 5.74 13.91
55 INT68814 Positive_regulation of Transcription of Oprm1 16 0.60 2.72 13.57
56 INT12325 Gene_expression of Plec 47 0.72 11.92 13.35
57 INT127819 Gene_expression of Luc7l3 76 0.28 18.4 13.22
58 INT48927 Regulation of Mapk3 25 0.60 14.06 12.82
59 INT74838 Positive_regulation of Sorbs1 18 0.34 6.93 12.63
60 INT62523 Positive_regulation of Phosphorylation of Oprm1 11 0.53 0.75 12.51
61 INT26973 Gene_expression of Tenc1 59 0.66 27.19 12
62 INT8533 Regulation of Sorbs1 9 0.27 3.01 11.98
63 INT86698 Gene_expression of Cav1 38 0.78 16.37 11.75
64 INT69029 Gene_expression of PTPRC 127 0.75 74.26 11.57
65 INT5630 Localization of Pdpk1 10 0.45 5.21 11.36
66 INT75525 Negative_regulation of Positive_regulation of MAPK1 40 0.59 25.15 11.15
67 INT6044 Regulation of Binding of Oprm1 16 0.61 3.01 11.11
68 INT59766 Positive_regulation of Negative_regulation of Oprm1 9 0.50 1.31 11.08
69 INT48921 Regulation of Mapk1 25 0.49 19.51 10.41
70 INT71592 Negative_regulation of Gene_expression of Oprm1 11 0.58 4.03 10.37
71 INT7411 Localization of FGFR3 40 0.78 4.77 10.24
72 INT67101 Gene_expression of DST 47 0.54 25.92 9.59
73 INT49483 Regulation of Positive_regulation of Oprm1 8 0.61 2.34 9.4
74 INT94196 Negative_regulation of Phosphorylation of MAPK1 60 0.59 31.64 9.16
75 INT8535 Localization of Sorbs1 9 0.80 2.71 9.07
76 INT163054 Gene_expression of Msn 20 0.66 0.6 9.06
77 INT109432 Negative_regulation of Phosphorylation of Mapk1 19 0.54 7.01 8.98
78 INT20835 Negative_regulation of Negative_regulation of Oprm1 10 0.43 0.56 8.96
79 INT111133 Negative_regulation of Mapk3 31 0.57 10.89 8.9
80 INT76162 Positive_regulation of Phosphorylation of Oprm1 11 0.69 0.64 8.72
81 INT98835 Positive_regulation of Transcription of Oprm1 15 0.65 2.47 8.67
82 INT18021 Positive_regulation of Binding of Oprm1 16 0.70 2.53 8.38
83 INT126848 Positive_regulation of Phosphorylation of Mapk1 30 0.50 15.94 8.34
84 INT195203 Binding of Tenc1 14 0.32 13.97 8.28
85 INT71785 Gene_expression of MAPK3 22 0.75 11.35 8.21
86 INT124702 Positive_regulation of Trpv4 21 0.69 7.14 8.2
87 INT72539 Gene_expression of Sorbs1 10 0.78 4.98 8.14
88 INT135443 Phosphorylation of Map2k1 11 0.80 2.44 8.01
89 INT82762 Positive_regulation of Positive_regulation of Mapk3 23 0.67 7.72 7.91
90 INT104013 Negative_regulation of Gene_expression of Pdpk1 4 0.31 2.36 7.89
91 INT135441 Positive_regulation of Map2k1 15 0.67 6.6 7.87
92 INT91238 Regulation of Negative_regulation of Oprm1 6 0.45 1.4 7.85
93 INT111607 Gene_expression of CDH1 103 0.75 90.45 7.77
94 INT62372 Positive_regulation of Localization of Oprm1 8 0.50 0.46 7.71
95 INT306287 Binding of TPPP 4 0.24 14.81 7.71
96 INT72372 Positive_regulation of Phosphorylation of Mapk3 30 0.67 13.6 7.69
97 INT72884 Positive_regulation of Tenc1 13 0.42 14.01 7.67
98 INT91618 Positive_regulation of Phosphorylation of MAPK3 21 0.67 7.99 7.65
99 INT76120 Gene_expression of Ptprc 102 0.59 30.42 7.02
100 INT16628 Negative_regulation of Positive_regulation of Oprm1 9 0.43 0.89 6.92
101 INT62524 Negative_regulation of Phosphorylation of Oprm1 7 0.59 0.08 6.92
102 INT75228 Positive_regulation of Negative_regulation of Oprm1 8 0.49 0.95 6.9
103 INT71824 Phosphorylation of Pdpk1 14 0.38 4.9 6.86
104 INT38644 Positive_regulation of DST 30 0.53 12.48 6.59
105 INT48928 Positive_regulation of Gene_expression of Mapk1 19 0.48 9.38 6.59
106 INT93137 Negative_regulation of Map2k1 17 0.42 4.51 6.49
107 INT5932 Regulation of Regulation of Oprm1 7 0.61 0.44 6.47
108 INT130875 Gene_expression of ADAM17 13 0.78 15.46 6.41
109 INT163052 Regulation of Msn 11 0.38 1.21 6.31
110 INT38595 Localization of BCAR1 8 0.73 2.9 6.25
111 INT124881 Binding of Trpv4 35 0.47 7.71 6.24
112 INT94197 Negative_regulation of Phosphorylation of MAPK3 13 0.57 5.51 6.18
113 INT48926 Positive_regulation of Gene_expression of Mapk3 12 0.46 6.02 6.13
114 INT53135 Positive_regulation of Localization of Oprm1 2 0.50 0 6.12
115 INT139964 Regulation of Phosphorylation of Mapk1 12 0.58 10.04 6.1
116 INT149385 Positive_regulation of TRPV4 11 0.69 7.22 6.02
117 INT118440 Gene_expression of TRPV4 20 0.71 7.33 6.01
118 INT169697 Negative_regulation of Ephx2 35 0.59 38.21 5.92
119 INT130111 Regulation of Positive_regulation of MAPK1 14 0.36 11.01 5.9
120 INT87470 Gene_expression of SDC1 27 0.78 24.86 5.81
121 INT55077 Positive_regulation of Positive_regulation of Pdpk1 6 0.26 1.77 5.78
122 INT83597 Phosphorylation of Ptk2 20 0.82 3.24 5.7
123 INT112927 Negative_regulation of Localization of Oprm1 4 0.39 0.31 5.59
124 INT105960 Gene_expression of Cdh1 41 0.76 22.28 5.56
125 INT68465 Positive_regulation of Gene_expression of Pdpk1 7 0.19 2.35 5.49
126 INT71779 Positive_regulation of Gene_expression of MAPK1 27 0.47 21.41 5.39
127 INT99487 Negative_regulation of MAPK3 15 0.57 7.13 5.39
128 INT135440 Positive_regulation of Phosphorylation of Map2k1 5 0.49 1.32 5.22
129 INT156296 Regulation of Trpv4 20 0.45 7.84 4.86
130 INT58079 Localization of Tenc1 13 0.68 5.9 4.75
131 INT94453 Gene_expression of ITGB1 50 0.75 18.41 4.72
132 INT251332 Negative_regulation of Limk1 1 0.59 16.43 4.66
133 INT72538 Negative_regulation of Sorbs1 7 0.59 4.49 4.61
134 INT1807 Negative_regulation of Bcar1 9 0.38 4.04 4.59
135 INT139894 Negative_regulation of Msn 11 0.41 0.36 4.52
136 INT205272 Positive_regulation of Gene_expression of Plec 11 0.43 1.5 4.49
137 INT208287 Binding of Msn 10 0.41 0.33 4.31
138 INT87345 Phosphorylation of PTK2 110 0.82 59.39 4.28
139 INT163365 Positive_regulation of TNS3 2 0.41 0.96 4.18
140 INT119063 Gene_expression of BRCA1 24 0.67 30.04 4.17
141 INT1231 Negative_regulation of Positive_regulation of Pdpk1 6 0.35 1.88 4.13
142 INT71868 Regulation of Tenc1 9 0.52 10.73 4.09
143 INT105998 Protein_catabolism of Oprm1 5 0.95 0.88 4.08
144 INT133244 Regulation of Positive_regulation of Mapk1 11 0.43 3.52 4.03
145 INT141443 Phosphorylation of Cav1 6 0.82 4.39 4.03
146 INT3405 Gene_expression of BCAR1 14 0.71 8.89 4.02
147 INT248973 Negative_regulation of Gene_expression of Luc7l3 14 0.08 2.19 3.99
148 INT109821 Negative_regulation of Trpv4 19 0.55 6.86 3.98
149 INT112782 Localization of Mapk3 8 0.78 1.87 3.98
150 INT106065 Negative_regulation of MAP2K1 27 0.57 12.69 3.97
151 INT51831 Negative_regulation of ITGA2B 20 0.57 10.59 3.91
152 INT153666 Gene_expression of CAV1 156 0.77 120.99 3.9
153 INT179391 Phosphorylation of Map2k2 1 0.02 7.01 3.89
154 INT94291 Regulation of Gene_expression of Mapk3 4 0.40 3.05 3.8
155 INT117773 Positive_regulation of Phosphorylation of Ptk2 9 0.69 0.89 3.71
156 INT195187 Positive_regulation of Msn 5 0.49 0.38 3.66
157 INT11761 Negative_regulation of DST 13 0.42 7.66 3.65
158 INT8536 Binding of Sorbs1 2 0.14 1.24 3.64
159 INT33739 Gene_expression of ITGA2B 25 0.75 8.19 3.6
160 INT161105 Gene_expression of Ephx2 20 0.78 17.84 3.58
161 INT174672 Positive_regulation of Luc7l3 15 0.26 4.82 3.5
162 INT102076 Regulation of DST 15 0.22 10 3.5
163 INT5929 Positive_regulation of Regulation of Oprm1 4 0.50 0.56 3.48
164 INT78284 Positive_regulation of PTPRC 40 0.49 27.17 3.45
165 INT8731 Regulation of Localization of Oprm1 3 0.43 0.25 3.4
166 INT184390 Binding of Arhgap4 13 0.36 3.29 3.35
167 INT129751 Regulation of Phosphorylation of Mapk3 11 0.55 3.91 3.35
168 INT7408 Negative_regulation of FGFR3 12 0.43 2.38 3.33
169 INT84409 Binding of TNS1 6 0.48 2.96 3.33
170 INT97737 Negative_regulation of Phosphorylation of Mapk3 9 0.57 5.64 3.3
171 INT68812 Regulation of Regulation of Oprm1 5 0.40 0.16 3.28
172 INT3403 Positive_regulation of BCAR1 18 0.63 18.95 3.23
173 INT181496 Regulation of TRPV4 3 0.23 3.32 3.23
174 INT112175 Negative_regulation of Gene_expression of Trpv4 8 0.59 3.7 3.12
175 INT38594 Positive_regulation of Localization of BCAR1 3 0.63 0.44 3.07
176 INT71783 Positive_regulation of Gene_expression of MAPK3 9 0.59 4.59 3.05
177 INT87288 Positive_regulation of Positive_regulation of MAPK3 5 0.67 1.62 3.04
178 INT7409 Negative_regulation of Localization of FGFR3 12 0.37 2.24 2.92
179 INT207532 Localization of Luc7l3 12 0.28 1.18 2.91
180 INT168744 Negative_regulation of Regulation of Trpv4 1 0.42 3.26 2.87
181 INT102157 Gene_expression of Adam17 3 0.58 4.17 2.86
182 INT200895 Localization of Mapk1 6 0.67 2.08 2.82
183 INT169112 Negative_regulation of Positive_regulation of Mapk1 9 0.59 1.84 2.78
184 INT169402 Binding of Trpv4 8 0.47 5.13 2.78
185 INT70377 Regulation of Transcription of Oprm1 3 0.47 0.93 2.78
186 INT53733 Positive_regulation of FGFR3 6 0.45 1.32 2.76
187 INT47846 Negative_regulation of Localization of Pdpk1 2 0.33 1.12 2.75
188 INT152927 Negative_regulation of Mapk1 16 0.41 5.85 2.73
189 INT86703 Positive_regulation of Gene_expression of Cav1 7 0.70 3.58 2.73
190 INT221269 Binding of BRCA1 14 0.40 31.77 2.7
191 INT115852 Transcription of Trpv4 9 0.71 2.23 2.65
192 INT174675 Negative_regulation of Luc7l3 5 0.18 2.09 2.65
193 INT96763 Positive_regulation of Localization of Pdpk1 1 0.39 2.08 2.65
194 INT87340 Negative_regulation of BCAR1 8 0.38 6.96 2.63
195 INT28817 Binding of TRPV4 6 0.39 3.92 2.59
196 INT122060 Positive_regulation of Positive_regulation of Sorbs1 2 0.34 0.06 2.57
197 INT179396 Positive_regulation of Map2k2 7 0.30 2.84 2.56
198 INT187454 Binding of Ptprc 34 0.38 9.66 2.54
199 INT204185 Gene_expression of TPPP 7 0.22 6.48 2.54
200 INT109822 Negative_regulation of Gene_expression of Trpv4 8 0.55 1.98 2.53
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