GO:0006029

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Name proteoglycan metabolic process
Categary Process
Go Slim No
Go Link GO:0006029
Unique Molecular Interactions 85
Total Molecular Interactions 115
Total Single Events 1099
Pain Genes Associated 12

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for proteoglycan metabolic process. They are ordered first by their pain relevance and then by number of times they were reported for proteoglycan metabolic process. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT109958 Binding of CRH and HPSE 1 0.10 0.72 1.46
2 INT311914 Il1 Negative_regulation of Gene_expression of Col2a1 1 0.01 1.94 1.23
3 INT204551 Binding of Col2a1 and Positive_regulation of Cia1 1 0.03 1.74 1.03
4 INT210783 Bmp2 Positive_regulation of Tnip1 1 0.40 0.53 0.94
5 INT210791 Bmp2 Positive_regulation of Net1 1 0.38 0.52 0.93
6 INT210799 Bmp2 Positive_regulation of B2m 1 0.35 0.52 0.92
7 INT140985 Gli3 Regulation of Ihh 1 0.29 0.85 0.85
8 INT149899 Ihh Positive_regulation of Mmp7 1 0.04 1.69 0.65
9 INT220145 HPSE Negative_regulation of Gene_expression of CRH 1 0.01 0.92 0.64
10 INT202043 MMP13 Regulation of Protein_catabolism of COL2A1 1 0.01 0.54 0.54
11 INT149894 Ihh Positive_regulation of Localization of Mmp14 1 0.04 2.06 0.47
12 INT210793 Bmp2 Positive_regulation of Tsc22d3 1 0.32 0.26 0.46
13 INT352387 Binding of CFP and HPSE 1 0.01 1.25 0.46
14 INT177440 Binding of HPSE and Gnrh1 1 0.00 1.82 0.45
15 INT160245 Binding of Col11a1 and Crygs 1 0.00 0.17 0.4
16 INT312122 ELANE Positive_regulation of Protein_catabolism of COL2A1 1 0.05 0.65 0.39
17 INT254344 Binding of Col2a1 and Ncoa5 1 0.00 0.98 0.35
18 INT149897 Ihh Positive_regulation of Mmp14 1 0.03 0.93 0.33
19 INT149896 Ihh Regulation of Gene_expression of Col1a1 1 0.06 0.89 0.33
20 INT149895 Ihh Regulation of Localization of Mmp7 1 0.03 0.98 0.33
21 INT149902 Ihh Positive_regulation of SGCG 1 0.45 0.76 0.32
22 INT224687 Il1 Positive_regulation of Bmp2 1 0.00 0.3 0.31
23 INT166165 Binding of TGFB3 and Bmp2 1 0.00 0 0.3
24 INT264523 PTGDS Positive_regulation of Gene_expression of COL2A1 1 0.03 1.24 0.3
25 INT220194 PTGER2 Negative_regulation of COL2A1 1 0.26 0.55 0.29
26 INT328224 Col2a1 Positive_regulation of Gene_expression of Mmp13 1 0.04 0.8 0.29
27 INT159201 Binding of Ppard and Ppara 1 0.01 0.68 0.28
28 INT149898 Ihh Regulation of Localization of Mmp14 1 0.03 1.29 0.27
29 INT210798 Ihh Positive_regulation of Itgbl1 1 0.34 0 0.23
30 INT60347 COL2A1 Positive_regulation of Gene_expression of Hras 1 0.05 0.92 0.2
31 INT220190 PTGER2 Regulation of COL2A1 1 0.32 0.92 0.18
32 INT220191 Binding of COL2A1 and PTGER2 1 0.22 0.35 0.18
33 INT210795 Ihh Negative_regulation of Itgb1 1 0.30 0 0.17
34 INT346305 Binding of ELANE and Col2a1 1 0.00 0.98 0.17
35 INT210782 Ihh Negative_regulation of Itgbl1 1 0.31 0 0.16
36 INT210804 Ihh Negative_regulation of Timp4 1 0.32 0 0.16
37 INT336337 Glp2r Positive_regulation of Gene_expression of Col2a1 1 0.01 0.7 0.14
38 INT293867 Binding of COL2A1 and MEFV 1 0.01 0.52 0.14
39 INT220213 Mmp13 Regulation of Protein_catabolism of COL2A1 1 0.49 0.29 0.14
40 INT311191 ecs Negative_regulation of HPSE 1 0.00 0.94 0.12
41 INT326974 BMP2 Positive_regulation of Gene_expression of COL2A1 1 0.07 0.27 0.11
42 INT165161 Ihh Positive_regulation of Sostdc1 1 0.58 0.07 0.09
43 INT220195 PTGER2 Negative_regulation of Localization of COL2A1 1 0.26 0.51 0.09
44 INT165160 Regulation of Ihh Positive_regulation of Sostdc1 1 0.23 0.07 0.09
45 INT165158 Positive_regulation of Ihh Positive_regulation of Sostdc1 1 0.42 0.07 0.09
46 INT338433 Il17f Positive_regulation of Gene_expression of IL8 1 0.01 1.62 0.09
47 INT346304 Col2a1 Positive_regulation of Localization of PTGER2 1 0.00 0.18 0.09
48 INT210788 Ihh Negative_regulation of Coro1a 1 0.02 0 0.08
49 INT210790 Ihh Negative_regulation of Cdkn1c 1 0.30 0 0.08
50 INT210787 Ihh Negative_regulation of Nr3c1 1 0.33 0 0.08
51 INT159461 SCN5A Negative_regulation of HPSE 1 0.00 0 0.07
52 INT159463 Ptprn2 Negative_regulation of HPSE 1 0.00 0 0.07
53 INT288003 Binding of COL2A1 and PADI1 1 0.09 0.11 0.06
54 INT295122 Bmp2 Regulation of Grxcr1 1 0.02 0.66 0.06
55 INT330487 Binding of MME and HPSE 1 0.35 0 0.06
56 INT295120 Bmp2 Regulation of Transcription of Pou1f1 1 0.24 0.66 0.06
57 INT346302 ELANE Regulation of Col2a1 1 0.00 0.3 0.05
58 INT220189 Binding of COL2A1 and TIMP1 1 0.04 0.1 0.05
59 INT346283 Binding of COL11A1 and ELANE 1 0.01 0.08 0.04
60 INT323807 NFAT5 Regulation of Gene_expression of COL2A1 1 0.29 0.19 0.04
61 INT346303 Binding of MR1 and Col2a1 1 0.00 0.09 0.04
62 INT220196 Binding of PTGER2 and Negative_regulation of Gene_expression of COL2A1 1 0.26 0.77 0.04
63 INT322891 Sox9 Regulation of Transcription of Col2a1 1 0.10 0.12 0.04
64 INT233397 Binding of ABCA4 and COL2A1 1 0.38 3.59 0.03
65 INT220245 IL1RN Regulation of Protein_catabolism of COL2A1 1 0.09 0 0.03
66 INT312346 FUT1 Positive_regulation of Gene_expression of COL11A1 1 0.17 1.02 0.03
67 INT293869 Binding of COL2A1 and GREM1 1 0.00 1.11 0
68 INT345168 Binding of Lpar1 and Ppard 1 0.03 0.21 0
69 INT288002 Binding of COL2A1 and GOPC 1 0.12 0 0
70 INT197794 Negative_regulation of Pthlh Regulation of Ihh 1 0.36 1.33 0
71 INT63391 SLTM Regulation of Gene_expression of Col2a1 1 0.00 0 0
72 INT312230 INPP5K Regulation of Gene_expression of COL2A1 1 0.06 0 0
73 INT196023 Bmp2 Negative_regulation of Gene_expression of Bmp4 1 0.09 0.07 0
74 INT147529 TGFB1 Negative_regulation of Gene_expression of Col2a1 1 0.05 0.32 0
75 INT196021 Bmp2 Positive_regulation of Gene_expression of Bmp4 1 0.09 0.08 0
76 INT88567 COL2A1 Positive_regulation of A1cf 1 0.09 0.36 0
77 INT312227 INPP5K Regulation of Negative_regulation of COL2A1 1 0.06 0 0
78 INT162510 Binding of ITPR1 and HPSE 1 0.02 0.05 0
79 INT295129 Proc Regulation of Bmp2 1 0.00 0.48 0
80 INT346285 Binding of COL11A1 and MR1 1 0.00 0.63 0
81 INT312345 Binding of COL2A1 and COL5A2 1 0.00 1.21 0
82 INT323804 NFAT5 Regulation of Transcription of COL2A1 1 0.43 0.07 0
83 INT321594 Bmp2 Regulation of Gene_expression of Lxn 1 0.42 1.71 0
84 INT312213 INPP5K Regulation of COL2A1 1 0.06 0 0
85 INT197793 Pthlh Regulation of Ihh 1 0.22 1.32 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for proteoglycan metabolic process. They are ordered first by their pain relevance and then by number of times they were reported in proteoglycan metabolic process. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT11659 Gene_expression of COL2A1 164 0.78 78.49 22.58
2 INT37618 Gene_expression of Col2a1 50 0.70 33.88 11.58
3 INT54834 Gene_expression of Col2a1 48 0.72 13.5 9.41
4 INT130731 Protein_catabolism of COL2A1 47 0.96 21.86 9.28
5 INT81608 Gene_expression of Col11a1 13 0.15 1.58 6.87
6 INT61114 Gene_expression of Ppard 23 0.75 14.98 6.62
7 INT254269 Gene_expression of Il17f 12 0.48 13.29 6.02
8 INT20552 Negative_regulation of Gene_expression of COL2A1 29 0.56 11.92 4.81
9 INT217742 Positive_regulation of Gene_expression of COL2A1 20 0.67 9.76 4.23
10 INT30014 Positive_regulation of HPSE 22 0.70 20.91 4.09
11 INT124815 Binding of Col2a1 9 0.37 10.27 3.93
12 INT61734 Regulation of HPSE 16 0.60 13.05 3.5
13 INT53021 Positive_regulation of COL2A1 29 0.55 27.75 3.47
14 INT130729 Negative_regulation of Protein_catabolism of COL2A1 15 0.42 7.59 3.35
15 INT39867 Binding of Col2a1 9 0.35 7.65 3.18
16 INT102034 Positive_regulation of Ppard 10 0.69 3.97 3.17
17 INT54832 Negative_regulation of Gene_expression of Col2a1 6 0.50 2.53 3.16
18 INT171884 Positive_regulation of Gene_expression of Col2a1 11 0.23 8.04 3.02
19 INT96423 Gene_expression of Bmp2 61 0.78 25.07 3.01
20 INT112758 Binding of Ppard 7 0.37 3.6 2.87
21 INT96338 Gene_expression of HPSE 17 0.75 18.71 2.73
22 INT20551 Negative_regulation of COL2A1 31 0.55 21.98 2.66
23 INT96693 Binding of COL2A1 45 0.46 37.11 2.61
24 INT102033 Negative_regulation of Ppard 5 0.37 4.14 2.48
25 INT350632 Positive_regulation of Il17f 2 0.29 6.22 1.96
26 INT164407 Negative_regulation of Gene_expression of Col2a1 6 0.39 4 1.78
27 INT220992 Protein_catabolism of Col2a1 8 0.40 5.55 1.64
28 INT95056 Positive_regulation of Gene_expression of Ppard 5 0.52 3.84 1.6
29 INT74955 Negative_regulation of HPSE 6 0.57 4.75 1.57
30 INT164410 Negative_regulation of Col2a1 4 0.39 3.75 1.53
31 INT32184 Negative_regulation of Col2a1 9 0.42 3.05 1.43
32 INT54831 Regulation of Gene_expression of Col2a1 4 0.39 2.3 1.31
33 INT117232 Localization of COL2A1 11 0.72 7.34 1.3
34 INT70619 Regulation of Bmp2 6 0.60 3.1 1.29
35 INT132495 Negative_regulation of Gene_expression of Ppard 4 0.44 2.64 1.28
36 INT300541 Negative_regulation of Gene_expression of Il17f 3 0.26 2.6 1.27
37 INT254179 Localization of Il17f 3 0.49 3.29 1.25
38 INT128714 Transcription of Col2a1 6 0.52 2.13 1.24
39 INT338411 Positive_regulation of Gene_expression of Il17f 5 0.29 4.58 1.21
40 INT176463 Protein_catabolism of Col2a1 4 0.35 1.94 1.2
41 INT140983 Gene_expression of Ihh 7 0.78 2.06 1.15
42 INT11658 Regulation of Gene_expression of COL2A1 9 0.62 3.09 1.11
43 INT96424 Transcription of Bmp2 6 0.69 6.34 1.11
44 INT54835 Regulation of Col2a1 5 0.59 2.08 1.07
45 INT160538 Binding of Bmp2 4 0.40 2.08 1.07
46 INT300538 Negative_regulation of Il17f 2 0.26 1.98 1.07
47 INT96229 Localization of HPSE 3 0.20 2.76 1.05
48 INT84235 Positive_regulation of Col11a1 2 0.01 0.09 1.03
49 INT168233 Positive_regulation of Transcription of Col2a1 2 0.45 1.78 0.99
50 INT112759 Negative_regulation of Binding of Ppard 2 0.39 2.08 0.99
51 INT173506 Positive_regulation of Col2a1 4 0.20 3.42 0.76
52 INT37617 Regulation of Gene_expression of Col2a1 3 0.31 1.48 0.7
53 INT96339 Protein_catabolism of HPSE 5 0.96 2.87 0.63
54 INT3503 Localization of COL11A1 3 0.65 2.17 0.63
55 INT63389 Localization of Col2a1 7 0.68 1.95 0.6
56 INT140984 Regulation of Ihh 5 0.54 2.81 0.56
57 INT177436 Binding of HPSE 2 0.47 1.81 0.52
58 INT300542 Binding of Il17f 2 0.05 1.68 0.5
59 INT32183 Positive_regulation of Negative_regulation of Col2a1 2 0.46 1.01 0.49
60 INT145301 Regulation of Gene_expression of Bmp2 1 0.32 1.16 0.48
61 INT125840 Positive_regulation of Binding of Col2a1 1 0.43 1.21 0.45
62 INT9732 Regulation of COL2A1 9 0.58 6.93 0.44
63 INT353934 Positive_regulation of Negative_regulation of Il17f 1 0.31 0.9 0.44
64 INT132946 Negative_regulation of Positive_regulation of Ppard 1 0.42 0.09 0.44
65 INT120086 Gene_expression of Bmp2 5 0.27 2.34 0.43
66 INT177437 Transcription of HPSE 2 0.23 3.44 0.41
67 INT3504 Binding of COL11A1 1 0.32 0 0.4
68 INT147700 Positive_regulation of Gene_expression of Col11a1 1 0.01 0 0.39
69 INT196026 Positive_regulation of Gene_expression of Bmp2 14 0.69 3.19 0.35
70 INT74954 Positive_regulation of Positive_regulation of HPSE 2 0.40 0.45 0.34
71 INT166716 Negative_regulation of Ihh 3 0.43 0.67 0.33
72 INT54833 Positive_regulation of Col2a1 5 0.52 1.1 0.32
73 INT177439 Negative_regulation of Positive_regulation of HPSE 1 0.21 1.48 0.32
74 INT180577 Positive_regulation of Protein_catabolism of COL2A1 2 0.12 0.91 0.31
75 INT144419 Regulation of Ppard 1 0.24 0.91 0.3
76 INT220209 Negative_regulation of Localization of COL2A1 1 0.41 0.48 0.29
77 INT61115 Localization of Ppard 2 0.66 1.99 0.28
78 INT277061 Positive_regulation of COL11A1 2 0.43 1.56 0.28
79 INT159198 Positive_regulation of Binding of Ppard 1 0.34 0.68 0.28
80 INT149893 Positive_regulation of Gene_expression of Ihh 1 0.69 0.62 0.26
81 INT149892 Gene_expression of Ihh 1 0.77 0.61 0.26
82 INT185908 Gene_expression of COL11A1 4 0.71 6.18 0.25
83 INT181524 Negative_regulation of Binding of Col2a1 1 0.13 1.05 0.25
84 INT96337 Positive_regulation of Gene_expression of HPSE 1 0.67 2.28 0.25
85 INT145305 Positive_regulation of Bmp2 12 0.69 8.65 0.24
86 INT275310 Positive_regulation of Protein_catabolism of Col2a1 1 0.16 0.88 0.22
87 INT149888 Localization of Ihh 1 0.75 0.77 0.2
88 INT312356 Regulation of COL11A1 1 0.22 1.55 0.19
89 INT148064 Localization of Bmp2 2 0.29 0.14 0.17
90 INT220208 Regulation of Protein_catabolism of COL2A1 1 0.26 0.28 0.17
91 INT251821 Negative_regulation of COL11A1 3 0.42 3.45 0.16
92 INT63646 Localization of Col2a1 3 0.77 0.37 0.16
93 INT97186 Regulation of Col11a1 1 0.01 0.74 0.16
94 INT338405 Regulation of Il17f 1 0.04 0.58 0.16
95 INT106010 Positive_regulation of Bmp2 2 0.26 0.91 0.15
96 INT95278 Positive_regulation of Gene_expression of Col2a1 2 0.47 0.21 0.13
97 INT221000 Phosphorylation of COL2A1 1 0.19 0.18 0.12
98 INT203079 Regulation of Transcription of Col2a1 1 0.05 0.07 0.11
99 INT196035 Localization of Bmp2 3 0.63 0.23 0.09
100 INT346288 Phosphorylation of Col2a1 1 0.02 0.73 0.08
101 INT163072 Regulation of Binding of Bmp2 1 0.30 0.52 0.08
102 INT74953 Positive_regulation of Regulation of HPSE 2 0.49 1.02 0.07
103 INT118191 Regulation of Regulation of HPSE 2 0.26 0.87 0.07
104 INT168919 Regulation of Regulation of Ihh 1 0.40 0.43 0.07
105 INT8906 Negative_regulation of Col11a1 1 0.01 0 0.07
106 INT284837 Localization of Col11a1 1 0.01 0 0.07
107 INT231709 Negative_regulation of Negative_regulation of Col2a1 1 0.27 0.18 0.06
108 INT196025 Negative_regulation of Bmp2 2 0.34 0.14 0.05
109 INT339669 Regulation of Col2a1 1 0.01 1.02 0.05
110 INT250505 Positive_regulation of Negative_regulation of COL2A1 1 0.41 0.57 0.05
111 INT272249 Negative_regulation of Negative_regulation of COL2A1 1 0.06 0 0.05
112 INT229753 Positive_regulation of Gene_expression of Bmp2 2 0.11 1.22 0.04
113 INT201964 Transcription of Col2a1 2 0.38 0.55 0.04
114 INT346287 Regulation of Binding of Col2a1 1 0.01 0.07 0.04
115 INT165149 Positive_regulation of Ihh 1 0.42 0.09 0.04
116 INT184729 Transcription of COL2A1 4 0.67 1.1 0
117 INT145300 Positive_regulation of Positive_regulation of Bmp2 2 0.34 1.03 0
118 INT165862 Positive_regulation of Binding of COL2A1 2 0.43 0 0
119 INT196031 Binding of Bmp2 1 0.16 0 0
120 INT312246 Regulation of Negative_regulation of COL2A1 1 0.07 0 0
121 INT312355 Transcription of COL11A1 1 0.63 0.69 0
122 INT278735 Negative_regulation of Gene_expression of Bmp2 1 0.43 0.06 0
123 INT322888 Negative_regulation of Ihh 1 0.26 0.45 0
124 INT176462 Positive_regulation of Protein_catabolism of Col2a1 1 0.16 0.21 0
125 INT278737 Positive_regulation of Transcription of Bmp2 1 0.47 1.4 0
126 INT120087 Negative_regulation of Gene_expression of Bmp2 1 0.11 0.14 0
127 INT312361 Regulation of Gene_expression of COL11A1 1 0.42 1.04 0
128 INT114719 Binding of Col11a1 1 0.19 0 0
129 INT264309 Regulation of Localization of Col2a1 1 0.26 0 0
130 INT322897 Negative_regulation of Transcription of COL2A1 1 0.17 0 0
131 INT63388 Positive_regulation of Localization of Col2a1 1 0.01 0.16 0
132 INT335965 Negative_regulation of Localization of HPSE 1 0.11 0.93 0
133 INT338412 Positive_regulation of Localization of Il17f 1 0.07 0.69 0
134 INT301356 Binding of Ihh 1 0.08 0.06 0
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