GO:0006089

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Name lactate metabolic process
Categary Process
Go Slim No
Go Link GO:0006089
Unique Molecular Interactions 104
Total Molecular Interactions 121
Total Single Events 1928
Pain Genes Associated 6

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for lactate metabolic process. They are ordered first by their pain relevance and then by number of times they were reported for lactate metabolic process. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT168019 Ldha Regulation of Gpt 1 0.01 0.15 0.88
2 INT168018 Positive_regulation of Ldha Regulation of Gpt 1 0.01 0.15 0.88
3 INT34823 Regulation of Binding of Ldha and Akr7a3 1 0.43 0.28 0.72
4 INT210144 Binding of Slc6a3 and Slc37a4 1 0.11 0.23 0.72
5 INT34824 Binding of Ldha and Akr7a3 1 0.36 0.28 0.71
6 INT134029 Olr696 Regulation of Ldha 1 0.00 0.15 0.68
7 INT100369 HIF1A Positive_regulation of Positive_regulation of VEGFA 1 0.29 0.99 0.62
8 INT108018 Binding of Slc37a4 and Clec4d 1 0.00 1.18 0.6
9 INT135176 Myst2 Regulation of Gene_expression of Hif1a 1 0.24 0.47 0.47
10 INT254360 Binding of EPAS1 and HIF1A 3 0.39 3.36 0.46
11 INT135178 Myst2 Regulation of Hif1a 1 0.24 0.44 0.44
12 INT125574 CS Regulation of Ldha 1 0.02 0.23 0.42
13 INT198647 TNF Positive_regulation of HIF1A 1 0.03 2.97 0.34
14 INT347399 RYBP Positive_regulation of Ldha 1 0.01 0 0.33
15 INT235872 Phosphorylation of Ppp2ca Positive_regulation of Slc37a4 1 0.00 0.15 0.31
16 INT355153 Gpt Positive_regulation of Positive_regulation of Ldha 1 0.02 1.33 0.3
17 INT235886 Ppp2ca Positive_regulation of Slc37a4 1 0.00 0.15 0.3
18 INT355152 Gpt Positive_regulation of Gene_expression of Ldha 1 0.02 1.26 0.29
19 INT308815 Got1 Positive_regulation of Ldha 1 0.09 0.71 0.24
20 INT308817 Ldha Positive_regulation of Tnf 1 0.06 0.71 0.24
21 INT254349 Positive_regulation of Binding of EPAS1 and HIF1A 1 0.00 0.92 0.23
22 INT282852 Binding of Slc37a4 and Slc5a8 1 0.01 0.77 0.21
23 INT162850 ISYNA1 Positive_regulation of Localization of HIF1A 1 0.05 0.25 0.21
24 INT282851 Binding of Slc37a4 and Sema6a 1 0.00 0.55 0.21
25 INT305003 HIF1A Regulation of SERPINE1 1 0.11 2.3 0.19
26 INT261459 Sftpd Negative_regulation of Ldha 1 0.08 0.63 0.18
27 INT47426 Chrna7 Positive_regulation of Localization of Ldha 1 0.05 0 0.18
28 INT198649 Binding of HIF1A and MIF 1 0.01 1.53 0.18
29 INT47427 Chrna7 Positive_regulation of Ldha 1 0.05 0 0.18
30 INT143440 HIF1A Positive_regulation of Gene_expression of VEGFA 1 0.52 0.45 0.17
31 INT181898 Binding of ROS1 and Positive_regulation of HIF1A 1 0.02 0.82 0.15
32 INT181897 ROS1 Negative_regulation of HIF1A 1 0.03 0.83 0.15
33 INT237418 Binding of Hif1a and Bace1 1 0.06 1.18 0.15
34 INT181895 ROS1 Positive_regulation of HIF1A 1 0.03 0.78 0.15
35 INT181894 ROS1 Regulation of HIF1A 1 0.02 0.82 0.13
36 INT323434 Osr1 Regulation of Hif1a 1 0.01 0.79 0.13
37 INT198671 HIF1A Regulation of Positive_regulation of Epo 1 0.00 1.37 0.13
38 INT323433 Osr1 Regulation of Protein_catabolism of Hif1a 1 0.01 0.8 0.13
39 INT232787 CYBB Positive_regulation of Positive_regulation of Hif1a 1 0.01 0.66 0.12
40 INT323431 Binding of Hif1a and Vhl 1 0.07 0.68 0.12
41 INT249923 Binding of Pah and Hif1a 1 0.31 1.16 0.12
42 INT305002 Binding of HIF1A and SERPINE1 1 0.07 1.17 0.11
43 INT199583 HIF1A Positive_regulation of Gene_expression of Vhl 1 0.26 1.39 0.11
44 INT312305 Binding of HIF1A and Positive_regulation of Transcription of VEGFA 1 0.17 2.8 0.1
45 INT102244 IL36RN Positive_regulation of Binding of HIF1A 1 0.06 1.07 0.1
46 INT102245 TNF Positive_regulation of Binding of HIF1A 1 0.18 1.09 0.1
47 INT102248 INS Positive_regulation of Binding of HIF1A 1 0.13 0.96 0.1
48 INT294455 KLK4 Negative_regulation of HIF1A 1 0.01 0 0.1
49 INT102246 Binding of HIF1A and INS 1 0.07 0.96 0.1
50 INT173061 Binding of HIF1A and LILRA3 1 0.03 1.24 0.09
51 INT173062 Binding of HIF1A and VHLL 1 0.04 1.26 0.09
52 INT173057 Positive_regulation of HIF1A Positive_regulation of Gene_expression of VEGFA 1 0.24 1.49 0.08
53 INT249920 Negative_regulation of Binding of Pah and Hif1a 1 0.37 0.76 0.08
54 INT178081 Negative_regulation of EDN1 Positive_regulation of HIF1A 1 0.04 1.18 0.08
55 INT178078 Positive_regulation of Binding of DBP and HIF1A 1 0.00 1 0.08
56 INT178080 EDN1 Positive_regulation of HIF1A 1 0.05 1.05 0.08
57 INT178103 Binding of DBP and HIF1A 1 0.00 0.99 0.07
58 INT247578 Hif1a Regulation of VEGFA 1 0.02 1.59 0.07
59 INT308328 Hif1a Regulation of Positive_regulation of Trib3 1 0.02 0.89 0.05
60 INT304322 Hif1a Positive_regulation of Positive_regulation of VEGFA 1 0.11 0.39 0.05
61 INT270825 P2rx7 Positive_regulation of Slc37a4 1 0.01 0 0.04
62 INT249921 Binding of Hif1a and Asph 1 0.05 0.41 0.04
63 INT102247 Binding of EPO and HIF1A 1 0.41 0.65 0.04
64 INT173060 Negative_regulation of VHLL Positive_regulation of Positive_regulation of HIF1A 1 0.04 0.66 0.04
65 INT179926 Litaf Positive_regulation of Ldha 1 0.01 0.4 0.04
66 INT297159 Gsta3 Negative_regulation of Hif1a 1 0.00 0.54 0.03
67 INT322471 Hif1a Positive_regulation of VEGFA 1 0.05 0.26 0.03
68 INT315499 Ctnnbl1 Positive_regulation of Ldha 1 0.29 0.26 0
69 INT247576 Binding of Hif1a and Vbp1 1 0.01 0.6 0
70 INT120880 Mb Positive_regulation of Ldha 1 0.07 0.55 0
71 INT189554 Binding of HIF1A and Positive_regulation of EGLN1 1 0.04 0.86 0
72 INT135174 Myst2 Positive_regulation of Binding of Hif1a 1 0.41 0 0
73 INT143438 HIF1A Regulation of Gene_expression of VEGFA 1 0.69 0.13 0
74 INT315543 NARFL Regulation of Gene_expression of HIF1A 1 0.01 0.63 0
75 INT181697 Positive_regulation of Ldha Negative_regulation of Cat 1 0.29 0.6 0
76 INT247574 Ube2e3 Positive_regulation of Hif1a 1 0.04 0.62 0
77 INT197900 Des Positive_regulation of Gene_expression of Ldha 1 0.02 0.31 0
78 INT241307 Positive_regulation of HIF1A Positive_regulation of Positive_regulation of EPO 1 0.12 0.64 0
79 INT247575 Binding of Epo and Hif1a 1 0.09 1.24 0
80 INT290478 Mitf Positive_regulation of HIF1A 1 0.57 0.61 0
81 INT135175 Myst2 Positive_regulation of Hif1a 1 0.41 0 0
82 INT347353 Binding of Ldha and Sds 1 0.12 0.07 0
83 INT189552 EGLN1 Positive_regulation of HIF1A 1 0.05 0.98 0
84 INT197899 Dlst Positive_regulation of Ldha 1 0.04 0.34 0
85 INT260496 Hif1a Regulation of Gene_expression of VEGFA 1 0.12 0.93 0
86 INT181696 Ldha Negative_regulation of Cat 1 0.27 1.16 0
87 INT249924 Cpox Positive_regulation of Hif1a 1 0.01 0.68 0
88 INT318102 Binding of RPL5 and Ldha 1 0.08 0.66 0
89 INT337352 Binding of ARNT and HIF1A 1 0.14 0.61 0
90 INT119045 HIF1A Regulation of Regulation of TP53 1 0.09 1.06 0
91 INT262710 Binding of Crem and Hif1a 1 0.00 1.85 0
92 INT119046 HIF1A Regulation of TP53 1 0.05 1.06 0
93 INT204730 PKD1P2 Negative_regulation of Ldha 1 0.05 0.37 0
94 INT244709 Binding of Ldha and Gpt 1 0.01 1.32 0
95 INT347352 Negative_regulation of Binding of Ldha and Sds 1 0.14 0.07 0
96 INT322470 Binding of Bcl6 and Hif1a 1 0.06 0.52 0
97 INT143439 Positive_regulation of HIF1A Regulation of Gene_expression of VEGFA 1 0.30 0.13 0
98 INT290479 Binding of HIF1A and Mitf 1 0.30 1.29 0
99 INT318099 Binding of Ldha and Ppia 1 0.36 0.66 0
100 INT119044 HIF1A Regulation of TCEAL1 1 0.02 1.06 0
101 INT313884 XRCC1 Positive_regulation of Localization of HIF1A 1 0.00 0.65 0
102 INT119047 HIF1A Regulation of Regulation of TCEAL1 1 0.08 1.06 0
103 INT197906 Dlst Positive_regulation of Gene_expression of Ldha 1 0.03 0.31 0
104 INT345487 HIF1A Positive_regulation of PMAIP1 1 0.27 1.23 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for lactate metabolic process. They are ordered first by their pain relevance and then by number of times they were reported in lactate metabolic process. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT3920 Localization of Ldha 241 0.81 83.08 58.72
2 INT374 Positive_regulation of Ldha 212 0.70 107.08 47.43
3 INT4369 Gene_expression of Ldha 157 0.76 88.12 22.45
4 INT1278 Negative_regulation of Ldha 93 0.59 37.66 19.36
5 INT4340 Positive_regulation of Localization of Ldha 46 0.70 14.52 15.66
6 INT105387 Gene_expression of HIF1A 116 0.77 98.62 14.66
7 INT107033 Gene_expression of Slc37a4 66 0.62 27.34 12.35
8 INT12191 Negative_regulation of Localization of Ldha 35 0.59 13.71 12.35
9 INT373 Regulation of Ldha 37 0.61 17.86 11.41
10 INT100379 Positive_regulation of HIF1A 69 0.69 57.31 10.4
11 INT82709 Negative_regulation of Slc37a4 17 0.34 3.41 8.6
12 INT45234 Binding of Ldha 20 0.37 9.8 8.18
13 INT11177 Localization of Ldha 17 0.81 5.74 6.13
14 INT135170 Positive_regulation of Hif1a 86 0.67 99.4 6.07
15 INT112713 Gene_expression of Hif1a 24 0.75 20.48 5.45
16 INT135172 Gene_expression of Hif1a 56 0.76 46.49 5.44
17 INT39900 Positive_regulation of Gene_expression of Ldha 36 0.50 20.35 5.22
18 INT112704 Positive_regulation of Hif1a 25 0.67 21.49 4.23
19 INT34822 Regulation of Localization of Ldha 12 0.57 4.03 3.65
20 INT28923 Negative_regulation of Ldha 8 0.58 4.94 3.11
21 INT112365 Regulation of HIF1A 27 0.60 21.24 3.05
22 INT105390 Positive_regulation of Gene_expression of HIF1A 27 0.49 26.3 2.88
23 INT45565 Positive_regulation of Positive_regulation of Ldha 7 0.39 1.54 2.77
24 INT134756 Positive_regulation of Gene_expression of Hif1a 8 0.50 11.14 2.68
25 INT21516 Negative_regulation of Positive_regulation of Ldha 13 0.43 4.73 2.53
26 INT169553 Positive_regulation of Slc37a4 9 0.13 2.94 2.49
27 INT17963 Gene_expression of Ldha 11 0.75 6.53 2.48
28 INT100381 Positive_regulation of Positive_regulation of HIF1A 12 0.49 12.05 2.17
29 INT112364 Negative_regulation of HIF1A 22 0.57 16.95 2.13
30 INT86460 Binding of Slc37a4 5 0.04 1.8 2.08
31 INT151018 Negative_regulation of Gene_expression of Ldha 8 0.32 5.48 2.05
32 INT54625 Protein_catabolism of Ldha 4 0.78 0.6 1.91
33 INT54626 Positive_regulation of Protein_catabolism of Ldha 2 0.44 0.55 1.73
34 INT63671 Negative_regulation of Protein_catabolism of Ldha 1 0.38 0.31 1.68
35 INT122597 Transcription of Hif1a 5 0.69 5.56 1.63
36 INT153723 Negative_regulation of Gene_expression of Hif1a 2 0.41 1.25 1.58
37 INT135171 Positive_regulation of Gene_expression of Hif1a 15 0.68 16.95 1.51
38 INT119048 Negative_regulation of Gene_expression of HIF1A 10 0.57 9.23 1.5
39 INT143443 Localization of HIF1A 14 0.78 10.93 1.49
40 INT232785 Localization of Hif1a 8 0.46 10.37 1.33
41 INT58861 Positive_regulation of Localization of Ldha 2 0.25 0.1 1.26
42 INT15594 Positive_regulation of Ldha 3 0.26 0.96 1.14
43 INT102249 Binding of HIF1A 39 0.36 30.47 1.04
44 INT88466 Regulation of Gene_expression of Ldha 5 0.33 4.07 0.97
45 INT205902 Regulation of Gene_expression of Slc37a4 1 0.09 0.4 0.93
46 INT63673 Positive_regulation of Binding of Ldha 2 0.44 1.91 0.9
47 INT150108 Positive_regulation of Gene_expression of Slc37a4 5 0.35 2.09 0.83
48 INT155352 Phosphorylation of HIF1A 3 0.79 3.34 0.83
49 INT100378 Protein_catabolism of HIF1A 7 0.96 5.05 0.8
50 INT135169 Binding of Hif1a 22 0.47 12.48 0.79
51 INT39901 Negative_regulation of Negative_regulation of Ldha 2 0.53 0 0.76
52 INT169731 Negative_regulation of Localization of HIF1A 1 0.57 0.57 0.73
53 INT100380 Negative_regulation of Positive_regulation of HIF1A 2 0.57 1.6 0.72
54 INT128795 Regulation of Positive_regulation of HIF1A 2 0.61 0.95 0.67
55 INT233837 Negative_regulation of Hif1a 9 0.26 12.72 0.65
56 INT112708 Negative_regulation of Hif1a 5 0.38 2.7 0.64
57 INT100382 Positive_regulation of Protein_catabolism of HIF1A 2 0.45 1.75 0.64
58 INT165333 Regulation of Ldha 1 0.17 0.62 0.64
59 INT100377 Negative_regulation of Protein_catabolism of HIF1A 1 0.57 0.9 0.63
60 INT136465 Regulation of Hif1a 5 0.39 7.05 0.62
61 INT112363 Regulation of Gene_expression of HIF1A 6 0.60 2.28 0.61
62 INT155353 Positive_regulation of Phosphorylation of HIF1A 1 0.49 2.58 0.61
63 INT135173 Regulation of Gene_expression of Hif1a 3 0.44 2.49 0.53
64 INT134758 Positive_regulation of Transcription of Hif1a 2 0.33 2.44 0.53
65 INT125791 Regulation of Localization of Ldha 1 0.22 0.09 0.52
66 INT153065 Regulation of Hif1a 8 0.28 8.57 0.51
67 INT86461 Positive_regulation of Binding of Slc37a4 1 0.02 0.57 0.51
68 INT153067 Positive_regulation of Positive_regulation of Hif1a 10 0.49 11.83 0.47
69 INT39902 Positive_regulation of Negative_regulation of Ldha 3 0.46 0.54 0.46
70 INT150103 Negative_regulation of Gene_expression of Slc37a4 3 0.32 0.81 0.41
71 INT247549 Transcription of Hif1a 7 0.42 8.77 0.36
72 INT175710 Regulation of Slc37a4 2 0.26 1.03 0.35
73 INT320784 Protein_catabolism of Hif1a 3 0.61 2.41 0.34
74 INT247563 Negative_regulation of Positive_regulation of Hif1a 1 0.16 9.12 0.32
75 INT173105 Transcription of HIF1A 6 0.67 4.47 0.28
76 INT232786 Positive_regulation of Localization of Hif1a 2 0.31 2.63 0.27
77 INT173103 Positive_regulation of Transcription of HIF1A 3 0.49 2.11 0.21
78 INT247564 Positive_regulation of Transcription of Hif1a 1 0.19 2.05 0.2
79 INT129927 Transcription of Ldha 3 0.42 1.41 0.18
80 INT249919 Regulation of Regulation of Hif1a 2 0.29 1.81 0.14
81 INT249908 Binding of Hif1a 2 0.31 1.48 0.14
82 INT249913 Regulation of Gene_expression of Hif1a 2 0.32 1.82 0.13
83 INT105392 Positive_regulation of Binding of HIF1A 5 0.45 3.83 0.1
84 INT282122 Positive_regulation of Gene_expression of Ldha 3 0.11 1.58 0.1
85 INT153064 Positive_regulation of Regulation of Hif1a 1 0.45 1.52 0.1
86 INT260478 Negative_regulation of Positive_regulation of Hif1a 2 0.30 1.23 0.09
87 INT260462 Negative_regulation of Binding of Hif1a 1 0.30 1.13 0.09
88 INT260451 Positive_regulation of Positive_regulation of Hif1a 1 0.36 1.01 0.08
89 INT297157 Negative_regulation of Negative_regulation of Hif1a 1 0.03 0.54 0.07
90 INT247560 Negative_regulation of Negative_regulation of Hif1a 1 0.16 2.06 0.07
91 INT143444 Positive_regulation of Localization of HIF1A 3 0.45 1.26 0.06
92 INT247553 Regulation of Negative_regulation of Hif1a 1 0.17 1.36 0.06
93 INT297158 Regulation of Localization of Hif1a 1 0.03 0.32 0.06
94 INT131335 Negative_regulation of Regulation of Ldha 1 0.25 0.56 0.06
95 INT256622 Regulation of Positive_regulation of Ldha 1 0.08 0.9 0.06
96 INT247559 Regulation of Positive_regulation of Hif1a 2 0.23 1.64 0.05
97 INT247555 Positive_regulation of Binding of Hif1a 2 0.31 1.15 0.05
98 INT297156 Localization of Hif1a 1 0.06 0.32 0.05
99 INT322464 Regulation of Localization of Hif1a 1 0.28 0.59 0.05
100 INT155174 Regulation of Regulation of HIF1A 3 0.24 1.57 0.04
101 INT173079 Positive_regulation of Regulation of HIF1A 1 0.26 0.64 0.04
102 INT249918 Regulation of Protein_catabolism of Hif1a 1 0.29 0.4 0.04
103 INT249916 Protein_catabolism of Hif1a 1 0.64 0.39 0.04
104 INT179919 Phosphorylation of Ldha 1 0.15 0.4 0.04
105 INT105389 Negative_regulation of Binding of HIF1A 4 0.42 3.2 0.03
106 INT189607 Regulation of Binding of HIF1A 2 0.06 1.49 0
107 INT347347 Negative_regulation of Binding of Ldha 1 0.27 0.07 0
108 INT315498 Positive_regulation of Transcription of Ldha 1 0.37 0.27 0
109 INT189594 Negative_regulation of Transcription of HIF1A 1 0.05 0.94 0
110 INT249915 Regulation of Positive_regulation of Hif1a 1 0.29 0.85 0
111 INT254318 Localization of Slc37a4 1 0.01 2.2 0
112 INT112706 Negative_regulation of Gene_expression of Hif1a 1 0.08 0 0
113 INT322450 Negative_regulation of Binding of Hif1a 1 0.26 0.32 0
114 INT116899 Negative_regulation of Localization of Ldha 1 0.59 0 0
115 INT282121 Negative_regulation of Gene_expression of Ldha 1 0.09 0.52 0
116 INT189606 Regulation of Transcription of HIF1A 1 0.06 0.46 0
117 INT249917 Regulation of Negative_regulation of Hif1a 1 0.29 0.29 0
118 INT175469 Phosphorylation of Slc37a4 1 0.06 1.54 0
119 INT247562 Negative_regulation of Transcription of Hif1a 1 0.16 2.39 0
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