GO:0006090

From wiki-pain
Jump to: navigation, search
Name pyruvate metabolic process
Categary Process
Go Slim No
Go Link GO:0006090
Unique Molecular Interactions 74
Total Molecular Interactions 100
Total Single Events 1164
Pain Genes Associated 10

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for pyruvate metabolic process. They are ordered first by their pain relevance and then by number of times they were reported for pyruvate metabolic process. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT187175 Binding of BSG and PPIA 1 0.14 2.23 1.64
2 INT140314 PCSK7 Positive_regulation of LDHA 1 0.07 1.6 1.4
3 INT187176 Binding of BSG and MMP1 1 0.09 1.18 1.08
4 INT190168 BSG Regulation of CDCP1 1 0.00 1.18 0.84
5 INT126598 Binding of BSG and OPRK1 1 0.01 0.05 0.72
6 INT65285 TGFBI Negative_regulation of Pc 1 0.20 0.79 0.59
7 INT145954 Binding of BSG and MME 1 0.00 0.81 0.47
8 INT148377 PDP1 Positive_regulation of NOTCH1 1 0.44 0.64 0.44
9 INT148380 PDP1 Positive_regulation of Positive_regulation of CP 1 0.12 0.64 0.44
10 INT17059 Binding of DLD and Oxt 1 0.03 0.22 0.41
11 INT20949 Binding of HTN1 and PC 1 0.27 0 0.38
12 INT190173 BSG Regulation of MMRN1 1 0.00 0.29 0.35
13 INT133109 Pc Positive_regulation of Pla2g6 1 0.34 0.28 0.28
14 INT283520 Binding of DLAT and Pain1 1 0.27 0.65 0.22
15 INT322011 BSG Regulation of P2RX7 1 0.00 0.48 0.21
16 INT188922 Binding of Pc and Nr1i2 1 0.11 0 0.19
17 INT188921 Binding of Pc and Ahr 1 0.12 0 0.19
18 INT188920 Pc Positive_regulation of Ahr 1 0.14 0 0.18
19 INT52711 BSG Regulation of ADCY1 1 0.01 0.1 0.12
20 INT3752 Binding of GOT1 and LDHA 1 0.11 0.68 0.12
21 INT227400 Binding of DLAT and HCC 1 0.01 2.82 0.11
22 INT283460 Binding of CTLA4 and DLAT 1 0.06 3.14 0.09
23 INT189957 Binding of LDHA and Pttg1 1 0.05 0.35 0.08
24 INT225650 DCPS Positive_regulation of PDHA1 1 0.00 0.41 0.07
25 INT227418 Binding of DLAT and Pdc 1 0.05 1.01 0.07
26 INT76965 Mpo Negative_regulation of DLD 1 0.26 0.91 0.07
27 INT310321 DLD Negative_regulation of COQ10A 1 0.01 0.06 0.05
28 INT305877 Pcx Regulation of Gene_expression of Atp6v0a2 1 0.01 1.45 0.04
29 INT283464 Binding of CD4 and DLAT 1 0.07 0.69 0.04
30 INT305885 Pcx Positive_regulation of Gene_expression of Atp6v0a2 1 0.01 1.45 0.04
31 INT188903 MUC5AC Positive_regulation of LDHA 1 0.00 1.2 0.04
32 INT305883 Pcx Negative_regulation of Binding of Tjp1 1 0.04 0.11 0.04
33 INT305875 Pcx Negative_regulation of Binding of Ocln 1 0.03 0.11 0.04
34 INT237683 Positive_regulation of LDHA Positive_regulation of MAPK8 1 0.02 0.16 0.03
35 INT354987 Cacna1a Regulation of Localization of LDHA 1 0.00 0.23 0.03
36 INT237682 LDHA Positive_regulation of MAPK14 1 0.02 0.16 0.03
37 INT283463 Binding of DLAT and GAGE4 1 0.00 1.1 0.03
38 INT283462 Binding of DLAT and HLA-DRB1 1 0.07 1.06 0.03
39 INT229205 Pc Regulation of Gene_expression of Cyp2c11 1 0.18 0.25 0.03
40 INT237680 LDHA Positive_regulation of MAPK8 1 0.02 0.16 0.03
41 INT291103 FFAR1 Regulation of Gene_expression of PDK4 1 0.03 0 0
42 INT258908 Binding of BSG and HLA-DQA1 1 0.00 0.1 0
43 INT279279 Binding of BSG and KLF1 1 0.00 0.65 0
44 INT291095 FFAR1 Regulation of PDHA1 1 0.03 0.27 0
45 INT291106 INS Regulation of Gene_expression of PDK4 1 0.14 0 0
46 INT291105 FFAR1 Negative_regulation of PDP1 1 0.05 0.29 0
47 INT291100 PDP1 Regulation of FFAR1 1 0.03 0 0
48 INT291111 Positive_regulation of PYGM Regulation of PDP1 1 0.02 0 0
49 INT291098 PYGM Positive_regulation of PDK4 1 0.02 0 0
50 INT305879 Binding of Ocln and Pcx 1 0.03 0 0
51 INT291112 PYGM Positive_regulation of Gene_expression of PDK4 1 0.02 0 0
52 INT325948 Ezr Regulation of Pcx 1 0.00 0.84 0
53 INT250588 Binding of BSG and MCTS1 1 0.11 1.83 0
54 INT291104 PYGM Regulation of Gene_expression of PDK4 1 0.01 0 0
55 INT291108 AGL Regulation of Gene_expression of PDK4 1 0.01 0 0
56 INT348759 Plat Regulation of LDHA 1 0.04 0.23 0
57 INT291101 Binding of PDHA1 and PDP1 1 0.22 0 0
58 INT305880 Pcx Regulation of Atp6v0a2 1 0.01 0 0
59 INT291110 PYGM Positive_regulation of Transcription of PDK4 1 0.02 0 0
60 INT176919 Binding of DLD and Bpifa2 1 0.00 0.08 0
61 INT305874 Binding of Pcx and Tjp1 1 0.03 0 0
62 INT186906 EIF1 Positive_regulation of Localization of LDHA 1 0.03 0 0
63 INT291096 INS Positive_regulation of PDP1 1 0.21 0.06 0
64 INT291107 Regulation of PDP1 Regulation of FFAR1 1 0.03 0 0
65 INT270122 Binding of Pth and Pc 1 0.05 0.1 0
66 INT348758 Plat Positive_regulation of LDHA 1 0.04 0.42 0
67 INT291109 PYGM Regulation of PDP1 1 0.02 0 0
68 INT291099 FFAR1 Regulation of PDP1 1 0.05 0 0
69 INT176920 DLD Positive_regulation of Binding of Bpifa2 1 0.00 0.08 0
70 INT305882 Binding of Pcx and Alms1 1 0.03 0.62 0
71 INT186889 Binding of AHR and PC 1 0.05 1.06 0
72 INT291094 FFAR1 Positive_regulation of Phosphorylation of PDP1 1 0.05 0.24 0
73 INT285232 Binding of CHKB and LDHA 1 0.06 0.1 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for pyruvate metabolic process. They are ordered first by their pain relevance and then by number of times they were reported in pyruvate metabolic process. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT16290 Gene_expression of BSG 60 0.68 38.73 32.86
2 INT712 Positive_regulation of LDHA 160 0.70 175.25 19.11
3 INT20622 Gene_expression of LDHA 107 0.76 77.97 16.3
4 INT9385 Localization of LDHA 74 0.81 31.67 10.5
5 INT17056 Gene_expression of DLD 37 0.57 13.15 5.47
6 INT187189 Positive_regulation of Gene_expression of BSG 1 0.61 6.21 5.02
7 INT12796 Binding of DLD 20 0.36 6.71 3.02
8 INT182667 Binding of DLAT 11 0.31 40.75 2.8
9 INT187187 Regulation of Gene_expression of BSG 3 0.40 3.84 2.8
10 INT7142 Positive_regulation of DLD 22 0.60 7.69 2.76
11 INT72812 Positive_regulation of BSG 2 0.49 2.2 2.76
12 INT53447 Negative_regulation of DLD 17 0.54 12.9 2.48
13 INT229200 Gene_expression of Pc 13 0.65 8.96 2.32
14 INT65284 Regulation of Pc 7 0.52 5.93 2.24
15 INT161500 Gene_expression of PC 42 0.67 9.02 2.2
16 INT9254 Negative_regulation of LDHA 23 0.43 13.3 2.2
17 INT14 Regulation of LDHA 22 0.57 15.26 2.14
18 INT9380 Positive_regulation of Localization of LDHA 14 0.70 4.1 1.66
19 INT20633 Positive_regulation of Gene_expression of LDHA 15 0.49 15.94 1.42
20 INT227413 Gene_expression of DLAT 12 0.44 13.21 1.36
21 INT20950 Positive_regulation of PC 12 0.60 2.76 1.19
22 INT182666 Negative_regulation of DLAT 2 0.38 9.01 1.16
23 INT67488 Binding of Pc 8 0.31 4.6 1.13
24 INT227416 Positive_regulation of DLAT 4 0.45 17.02 1.11
25 INT174839 Localization of BSG 4 0.68 2.91 0.98
26 INT174029 Protein_catabolism of BSG 5 0.01 2.5 0.95
27 INT61613 Regulation of DLD 6 0.34 2.96 0.92
28 INT20627 Regulation of Gene_expression of LDHA 5 0.42 4.07 0.92
29 INT24815 Binding of LDHA 9 0.36 6.73 0.89
30 INT68447 Positive_regulation of PDP1 11 0.64 5.69 0.83
31 INT84646 Binding of PDHA1 2 0.32 1.36 0.8
32 INT48909 Localization of DLD 9 0.63 3.37 0.75
33 INT161501 Binding of PC 20 0.47 5.74 0.72
34 INT187185 Regulation of BSG 2 0.44 1.61 0.66
35 INT189574 Positive_regulation of PDK4 9 0.66 3.11 0.55
36 INT55594 Negative_regulation of Positive_regulation of DLD 1 0.02 0.62 0.53
37 INT9384 Positive_regulation of Positive_regulation of LDHA 3 0.50 5.5 0.52
38 INT354253 Localization of PDHA1 1 0.01 0.79 0.48
39 INT283507 Negative_regulation of Gene_expression of DLAT 1 0.28 2.2 0.48
40 INT32100 Negative_regulation of BSG 1 0.03 0 0.4
41 INT187902 Negative_regulation of PC 4 0.48 1.22 0.39
42 INT161504 Positive_regulation of Gene_expression of PC 4 0.44 1.75 0.39
43 INT5223 Negative_regulation of PDP1 8 0.41 1.74 0.37
44 INT187182 Binding of BSG 7 0.32 2.83 0.37
45 INT20629 Negative_regulation of Gene_expression of LDHA 4 0.41 1.78 0.34
46 INT99126 Negative_regulation of Positive_regulation of LDHA 4 0.43 4.37 0.32
47 INT187928 Positive_regulation of Pc 3 0.42 1.95 0.31
48 INT186895 Localization of PC 5 0.65 1.16 0.3
49 INT163542 Localization of Pc 2 0.66 1.34 0.29
50 INT227415 Regulation of DLAT 2 0.29 2.93 0.28
51 INT227417 Protein_catabolism of DLAT 1 0.44 1.51 0.27
52 INT291134 Gene_expression of PDP1 4 0.62 0.64 0.26
53 INT227414 Localization of DLAT 2 0.49 5.14 0.26
54 INT78370 Phosphorylation of BSG 1 0.01 0.05 0.26
55 INT225654 Gene_expression of PDHA1 8 0.44 3.18 0.25
56 INT68448 Negative_regulation of Positive_regulation of PDP1 4 0.40 1.84 0.24
57 INT126987 Gene_expression of Pcx 10 0.34 4.82 0.23
58 INT174027 Negative_regulation of Protein_catabolism of BSG 1 0.01 0.52 0.23
59 INT283509 Regulation of Binding of DLAT 1 0.29 1.99 0.23
60 INT75119 Negative_regulation of Localization of LDHA 1 0.32 0.48 0.21
61 INT161404 Negative_regulation of Pc 3 0.49 0.95 0.2
62 INT229196 Regulation of Gene_expression of Pc 3 0.38 1.37 0.2
63 INT283508 Negative_regulation of Negative_regulation of DLAT 1 0.28 1.87 0.19
64 INT291123 Regulation of PDK4 4 0.43 0.3 0.18
65 INT128120 Transcription of DLD 1 0.67 0 0.18
66 INT43708 Negative_regulation of Binding of DLD 1 0.35 0.17 0.17
67 INT305870 Localization of Pcx 1 0.32 1.1 0.16
68 INT225657 Positive_regulation of Gene_expression of PDHA1 1 0.01 0.65 0.14
69 INT283498 Negative_regulation of Localization of DLAT 1 0.28 1.77 0.14
70 INT187905 Negative_regulation of Gene_expression of PC 2 0.37 0.11 0.13
71 INT161499 Positive_regulation of Binding of PC 1 0.38 0.75 0.13
72 INT189569 Transcription of PDK4 2 0.68 0.52 0.12
73 INT189565 Positive_regulation of Transcription of PDK4 2 0.48 0.52 0.12
74 INT83129 Protein_catabolism of DLD 1 0.02 0 0.12
75 INT164473 Negative_regulation of Pcx 1 0.37 0.06 0.1
76 INT225661 Positive_regulation of PDHA1 10 0.46 2.38 0.09
77 INT186575 Protein_catabolism of Pc 1 0.57 0.09 0.09
78 INT291118 Transcription of PDP1 1 0.64 0 0.09
79 INT137756 Regulation of Negative_regulation of DLD 1 0.02 0.09 0.09
80 INT129929 Transcription of LDHA 4 0.17 4.48 0.08
81 INT291143 Binding of PDP1 3 0.34 0.5 0.08
82 INT291129 Negative_regulation of Binding of PDHA1 1 0.28 0.1 0.08
83 INT291120 Negative_regulation of Binding of PDP1 1 0.40 0 0.08
84 INT229198 Negative_regulation of Gene_expression of Pc 1 0.25 0.78 0.08
85 INT124293 Negative_regulation of PDHA1 4 0.28 0.66 0.07
86 INT229197 Positive_regulation of Gene_expression of Pc 2 0.42 0.5 0.07
87 INT9379 Regulation of Localization of LDHA 4 0.27 0.96 0.06
88 INT244341 Regulation of Binding of DLD 1 0.30 0.19 0.06
89 INT187904 Regulation of PC 1 0.24 0.18 0.05
90 INT187903 Positive_regulation of Regulation of PC 1 0.40 0 0.05
91 INT342587 Regulation of Binding of LDHA 1 0.44 1.12 0.04
92 INT187901 Negative_regulation of Localization of PC 1 0.37 0.32 0.04
93 INT291150 Gene_expression of PDK4 25 0.74 0.34 0.03
94 INT291152 Phosphorylation of PDP1 1 0.76 0.97 0.03
95 INT223781 Binding of Pcx 2 0.16 0.59 0
96 INT291137 Regulation of Negative_regulation of PDK4 1 0.43 0 0
97 INT291127 Regulation of PDHA1 1 0.26 0.08 0
98 INT291116 Negative_regulation of PDK4 1 0.56 0.07 0
99 INT254612 Phosphorylation of PC 1 0.67 0.42 0
100 INT291133 Regulation of Gene_expression of PDK4 1 0.59 0 0
101 INT227412 Transcription of DLAT 1 0.34 1.4 0
102 INT291155 Regulation of Phosphorylation of PDP1 1 0.42 0.16 0
103 INT151585 Phosphorylation of Pcx 1 0.05 0.16 0
104 INT291144 Positive_regulation of Regulation of PDP1 1 0.46 0.4 0
105 INT151582 Positive_regulation of Phosphorylation of Pcx 1 0.03 0.16 0
106 INT187900 Negative_regulation of Regulation of PC 1 0.37 0 0
107 INT291153 Positive_regulation of Gene_expression of PDK4 1 0.48 0.06 0
108 INT291115 Positive_regulation of Regulation of PDK4 1 0.48 0 0
109 INT217416 Positive_regulation of Positive_regulation of DLD 1 0.42 0.19 0
110 INT291148 Regulation of PDP1 1 0.57 1.08 0
111 INT221520 Negative_regulation of Gene_expression of DLD 1 0.04 0.27 0
112 INT291119 Positive_regulation of Positive_regulation of PDP1 1 0.46 0.33 0
113 INT335116 Regulation of Positive_regulation of PDK4 1 0.02 0.23 0
114 INT283510 Positive_regulation of Localization of DLAT 1 0.33 1.21 0
115 INT305868 Positive_regulation of Pcx 1 0.20 0.19 0
116 INT291131 Phosphorylation of PDHA1 1 0.54 0.38 0
117 INT305865 Positive_regulation of Gene_expression of Pcx 1 0.21 0 0
118 INT291135 Positive_regulation of Binding of PDHA1 1 0.29 0.24 0
119 INT291154 Negative_regulation of Gene_expression of PDP1 1 0.40 0 0
120 INT339760 Positive_regulation of Positive_regulation of PDK4 1 0.31 0.39 0
121 INT291142 Regulation of Binding of PDP1 1 0.42 0.16 0
122 INT250601 Regulation of Binding of BSG 1 0.11 0.5 0
123 INT188912 Phosphorylation of Pc 1 0.31 0 0
124 INT305866 Regulation of Pcx 1 0.19 0 0
125 INT291121 Negative_regulation of Gene_expression of PDK4 1 0.56 0.05 0
126 INT291136 Positive_regulation of Phosphorylation of PDP1 1 0.46 0.36 0
127 INT187930 Positive_regulation of Binding of Pc 1 0.04 0.19 0
Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox