GO:0006091

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Name generation of precursor metabolites and energy
Categary Process
Go Slim Yes
Go Link GO:0006091
Unique Molecular Interactions 1029
Total Molecular Interactions 1703
Total Single Events 16344
Pain Genes Associated 26

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for generation of precursor metabolites and energy. They are ordered first by their pain relevance and then by number of times they were reported for generation of precursor metabolites and energy. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT69872 Binding of MC1R and POMC 52 0.54 8.87 18.3
2 INT6078 Pomc Positive_regulation of Localization of Penk 13 0.51 0 15.49
3 INT10268 Binding of PDYN and POMC 11 0.39 0.08 10.36
4 INT6079 Pomc Positive_regulation of Penk 9 0.43 0 9.46
5 INT2714 Pomc Positive_regulation of Localization of Prl 17 0.79 0.5 8.18
6 INT91538 Pomc Positive_regulation of P9Ehs1 6 0.11 1.47 6.23
7 INT92466 Pomc Positive_regulation of Binding of Crygs 8 0.06 0 5.56
8 INT15842 Crh Positive_regulation of Localization of Pomc 15 0.73 5 5.05
9 INT1310 Pomc Regulation of Localization of Prl 9 0.40 0.61 4.96
10 INT211710 Binding of Mc1r and a 7 0.44 0.37 4.78
11 INT29206 Crh Regulation of Localization of POMC 4 0.64 0.96 4.68
12 INT32444 Binding of Cpe and Pomc 2 0.22 0 4.47
13 INT113223 POMC Regulation of MC1R 6 0.68 0.39 4.24
14 INT1313 Pomc Positive_regulation of Prl 7 0.35 0 4.19
15 INT29240 Binding of POMC and YY1 5 0.40 0.17 4.06
16 INT34220 Binding of POMC and Oprl1 4 0.01 0.25 4.05
17 INT20456 Binding of Pomc and Penk 9 0.41 0.26 3.93
18 INT24388 CRH Positive_regulation of Localization of POMC 8 0.51 5.67 3.35
19 INT7436 CFP Positive_regulation of Binding of POMC 1 0.02 0.18 3.35
20 INT17456 Binding of CSF2 and POMC 3 0.32 4.06 3.15
21 INT6076 Negative_regulation of Pomc Positive_regulation of Penk 3 0.31 0 3.14
22 INT81708 POMC Regulation of Gene_expression of ITGAM 1 0.53 0.72 3.1
23 INT134212 CRH Regulation of Localization of POMC 1 0.47 2.89 2.9
24 INT32656 Pomc Positive_regulation of Rbm39 1 0.08 0.42 2.84
25 INT107723 POMC Positive_regulation of MC1R 7 0.68 0.71 2.82
26 INT31513 Crh Regulation of POMC 3 0.29 5.06 2.78
27 INT30345 Pomc Regulation of Localization of Penk 3 0.31 0 2.61
28 INT29446 Crh Positive_regulation of Localization of POMC 8 0.38 1.87 2.58
29 INT21520 Crh Regulation of Pomc 3 0.22 0.4 2.45
30 INT56726 Cpe Negative_regulation of Pomc 1 0.07 0 2.41
31 INT214144 Cck Positive_regulation of Pomc 1 0.15 0.94 2.39
32 INT51317 Binding of POMC and OR5D2P 1 0.00 0.6 2.23
33 INT34310 CRH Positive_regulation of POMC 3 0.42 0.62 2.21
34 INT32586 H2-Ab1 Regulation of Pomc 1 0.03 0.14 2.19
35 INT1315 Pomc Positive_regulation of Localization of Gnrhr 3 0.38 0.16 2.16
36 INT49242 Binding of Mc1r and Pomc 10 0.38 3.79 2.15
37 INT135868 Zfp821 Positive_regulation of Binding of ACAA1 1 0.00 0 2.11
38 INT28387 Pomc Positive_regulation of Localization of LH 2 0.40 0.28 2.07
39 INT138962 Dbi Positive_regulation of Pomc 1 0.00 1.53 2
40 INT32585 H2-Ab1 Negative_regulation of Pomc 1 0.03 0.13 2
41 INT60626 Crh Positive_regulation of Localization of Pomc 7 0.54 2.3 1.99
42 INT26948 Pomc Positive_regulation of Localization of Gh1 2 0.22 0.15 1.99
43 INT264953 Binding of POMC and TLR4 1 0.03 0.89 1.96
44 INT264947 Binding of POMC and TLR2 1 0.03 0.89 1.95
45 INT91607 Binding of EDN1 and POMC 1 0.12 0 1.9
46 INT31438 Penk Positive_regulation of Localization of Pomc 1 0.18 0 1.9
47 INT19496 Pomc Regulation of Localization of Ins1 1 0.55 0.33 1.82
48 INT26676 Pomc Regulation of Localization of Trh 3 0.14 0 1.73
49 INT24817 Binding of POMC and VTN 8 0.42 0.39 1.71
50 INT56134 CALCA Positive_regulation of POMC 2 0.71 0.72 1.68
51 INT45306 Pomc Positive_regulation of ENG 2 0.07 1.11 1.68
52 INT119918 Zfp821 Positive_regulation of Binding of ACAA1 1 0.00 0 1.64
53 INT32412 Penk Regulation of Pomc 3 0.21 0.36 1.62
54 INT86637 POMC Regulation of Gene_expression of KRT16 2 0.47 1.22 1.61
55 INT94270 Pomc Regulation of Transcription of Crh 1 0.17 0.67 1.6
56 INT66408 Pomc Positive_regulation of Regulation of HRH1 1 0.01 0 1.58
57 INT41652 Binding of Pomc and Oprl1 3 0.16 0 1.57
58 INT94271 Pomc Regulation of Avp 1 0.20 0.67 1.57
59 INT81710 POMC Regulation of Gene_expression of FCGR3B 1 0.50 0.34 1.57
60 INT81709 POMC Regulation of Gene_expression of ITGB2 1 0.40 0.34 1.57
61 INT81719 POMC Regulation of Gene_expression of ITGAL 1 0.35 0.34 1.57
62 INT81712 POMC Regulation of FCGR3B 1 0.16 0.34 1.56
63 INT81715 POMC Regulation of ITGB2 1 0.40 0.34 1.55
64 INT81721 POMC Regulation of ITGAM 1 0.39 0.34 1.55
65 INT81714 POMC Regulation of ITGAL 1 0.15 0.34 1.54
66 INT32152 POMC Positive_regulation of Gene_expression of IFNA1 2 0.67 0 1.53
67 INT145072 ASIP Negative_regulation of MC1R 1 0.29 0 1.52
68 INT23548 Negative_regulation of CNDP2 Negative_regulation of Localization of POMC 1 0.03 0 1.52
69 INT140017 Avp Positive_regulation of Gene_expression of Pomc 1 0.38 0.85 1.52
70 INT69709 NPL Positive_regulation of Localization of POMC 2 0.36 1.22 1.51
71 INT32657 Positive_regulation of Pomc Positive_regulation of Rbm39 1 0.08 0.22 1.51
72 INT76656 POMC Positive_regulation of Gene_expression of Il6 1 0.03 0 1.51
73 INT140008 Avp Positive_regulation of Pomc 1 0.38 0.84 1.51
74 INT166360 Negative_regulation of Crhr1 Negative_regulation of Positive_regulation of Pomc 1 0.02 0.36 1.5
75 INT40209 TNS3 Regulation of POMC 1 0.16 0.27 1.47
76 INT12691 SST Negative_regulation of Localization of POMC 3 0.24 1.24 1.45
77 INT1314 Pomc Regulation of Localization of Gnrhr 2 0.16 0.14 1.45
78 INT21425 Binding of Pomc and Gtpbp4 1 0.01 0.1 1.45
79 INT150682 Pomc Regulation of Gene_expression of Eif2ak3 1 0.37 0.17 1.44
80 INT154111 POMC Positive_regulation of Localization of PENK 1 0.34 0.05 1.41
81 INT28992 Tmpo Positive_regulation of Pomc 1 0.36 3.18 1.41
82 INT154110 PENK Positive_regulation of Localization of POMC 1 0.34 0.05 1.41
83 INT154113 POMC Positive_regulation of YY1 1 0.70 0.06 1.41
84 INT27123 Binding of Pomc and Cck 2 0.31 0 1.38
85 INT66569 Pomc Positive_regulation of Atxn2l 1 0.03 0 1.36
86 INT38453 Binding of Pomc and Penk 1 0.17 0 1.33
87 INT2641 Binding of Pomc and Lct 2 0.31 0.57 1.32
88 INT59446 Rbm39 Positive_regulation of Negative_regulation of Pomc 1 0.03 0.19 1.32
89 INT31008 Crh Positive_regulation of Pomc 3 0.49 2.31 1.28
90 INT86636 POMC Positive_regulation of Gene_expression of KRT16 2 0.39 0.83 1.28
91 INT42579 SOD1 Negative_regulation of POMC 1 0.16 0.43 1.27
92 INT34052 POMC Regulation of Gene_expression of IFNG 1 0.11 0 1.27
93 INT5518 Pomc Negative_regulation of Crh 2 0.36 0.42 1.26
94 INT42580 CAT Negative_regulation of POMC 1 0.20 0.42 1.26
95 INT84886 APC Regulation of PPARD 1 0.51 1.57 1.26
96 INT46853 POMC Regulation of GAST 1 0.11 0.07 1.26
97 INT45269 POMC Negative_regulation of Penk 1 0.01 0 1.24
98 INT34471 Negative_regulation of Pomc Regulation of Slc3a1 1 0.05 0.12 1.24
99 INT123453 Binding of POMC and Penk 1 0.01 0.31 1.23
100 INT50385 Bdnf Positive_regulation of Pomc 1 0.22 0.47 1.23
101 INT34473 Pomc Regulation of Slc3a1 1 0.03 0.07 1.23
102 INT40900 PDYN Regulation of Localization of POMC 2 0.07 0.56 1.22
103 INT82754 Cck Positive_regulation of Positive_regulation of Pomc 1 0.39 0.3 1.21
104 INT17601 Binding of POMC and Oprl1 1 0.01 0 1.2
105 INT83428 Binding of ADIPOQ and FRTS 3 0.18 2.02 1.19
106 INT35459 POMC Negative_regulation of Gene_expression of IL16 1 0.45 0 1.19
107 INT34661 Abat Positive_regulation of Localization of Pomc 1 0.04 0 1.18
108 INT43509 Avp Positive_regulation of Localization of POMC 2 0.13 1.26 1.16
109 INT105240 POMC Positive_regulation of Gene_expression of CXCL10 1 0.07 1.18 1.16
110 INT94509 Il1b Positive_regulation of Gene_expression of AVP 1 0.36 1.96 1.15
111 INT88778 Binding of Oprm1 and Pomc 3 0.21 0.56 1.14
112 INT94508 Il6 Positive_regulation of Gene_expression of AVP 1 0.42 1.96 1.14
113 INT13098 POMC Regulation of Localization of CGA 1 0.58 0 1.14
114 INT30359 Pomc Regulation of Localization of Oxt 1 0.03 0 1.13
115 INT59035 Binding of CPB1 and POMC 1 0.00 0 1.12
116 INT102421 POMC Regulation of Gene_expression of Fos 1 0.12 0.34 1.11
117 INT29874 OXTR Negative_regulation of POMC 1 0.22 0 1.1
118 INT107938 POMC Positive_regulation of Gene_expression of TGFBR2 1 0.42 1.09 1.07
119 INT69874 POMC Negative_regulation of TYRP1 1 0.13 0 1.07
120 INT69871 ASIP Negative_regulation of TYRP1 1 0.36 0 1.07
121 INT30575 SST Negative_regulation of Localization of Pomc 1 0.00 0.71 1.06
122 INT57508 Pomc Negative_regulation of Adarb1 1 0.01 0.22 1.05
123 INT58807 Pomc Negative_regulation of Localization of LH 2 0.06 0 1.02
124 INT19494 Pomc Positive_regulation of Localization of Ins1 2 0.62 0.38 1.02
125 INT101381 POMC Regulation of Localization of IL8 1 0.28 1.49 1.02
126 INT63103 AVP Regulation of OXT 1 0.28 0.68 1.02
127 INT160879 POMC Positive_regulation of DECR1 1 0.04 0.08 1.02
128 INT106706 POMC Negative_regulation of Binding of FN1 1 0.19 0.79 1.02
129 INT6930 Binding of Oprk1 and Pomc 1 0.08 0.16 1.01
130 INT21415 POMC Positive_regulation of Gene_expression of IL2 1 0.00 0.27 1
131 INT32327 POMC Positive_regulation of Localization of PRL 4 0.45 0 0.99
132 INT175805 Crh Positive_regulation of Gene_expression of POMC 1 0.12 1.07 0.99
133 INT22109 Positive_regulation of Pomc Positive_regulation of Penk 1 0.35 0 0.99
134 INT38579 Binding of POMC and Hps4 1 0.00 0.32 0.99
135 INT1415 Binding of OPRM1 and POMC 3 0.16 0.3 0.98
136 INT31494 Pomc Regulation of Crh 2 0.12 0.13 0.97
137 INT165942 Bmp7 Positive_regulation of Transcription of Pomc 1 0.29 0.43 0.95
138 INT165940 Bmp7 Positive_regulation of Pomc 1 0.29 0.43 0.95
139 INT43454 Pomc Regulation of Localization of Avp 2 0.24 0.89 0.94
140 INT62109 SLC25A4 Negative_regulation of Localization of Gh 1 0.06 0 0.94
141 INT106707 POMC Regulation of Binding of LAMB2 1 0.03 0.7 0.94
142 INT1654 Pomc Regulation of DSP 1 0.03 0 0.94
143 INT20888 POMC Positive_regulation of Localization of PDYN 1 0.40 0 0.92
144 INT34457 AGT Positive_regulation of POMC 1 0.01 0 0.91
145 INT291011 Pomc Regulation of Gene_expression of ENG 1 0.08 0.86 0.91
146 INT64717 Pomc Positive_regulation of Il6 1 0.13 0.19 0.9
147 INT62111 SLC25A4 Negative_regulation of Regulation of Ghrh 1 0.41 0 0.9
148 INT40636 Mif Negative_regulation of Pomc 1 0.25 0.07 0.9
149 INT86589 Oprd1 Regulation of Localization of Pomc 1 0.18 0 0.9
150 INT56779 Pomc Negative_regulation of Gene_expression of Odc1 2 0.31 0 0.89
151 INT161916 Binding of POMC and Oprd1 1 0.01 0 0.89
152 INT161917 Negative_regulation of Binding of POMC and Oprd1 1 0.01 0 0.89
153 INT264944 Binding of POMC and BOC 1 0.07 0.44 0.89
154 INT26991 Pomc Negative_regulation of Localization of Ins1 1 0.38 0 0.89
155 INT97184 Oprm1 Regulation of Gene_expression of Pomc 1 0.31 0 0.89
156 INT66371 Pomc Regulation of Gene_expression of Crh 2 0.49 0 0.88
157 INT161915 Negative_regulation of Binding of POMC and YY1 1 0.33 0 0.88
158 INT26987 Pomc Regulation of Ins1 1 0.40 0 0.87
159 INT31495 Pomc Regulation of Localization of Gnrh1 2 0.04 0 0.86
160 INT40742 Pomc Regulation of Localization of Gh1 1 0.37 0 0.86
161 INT59497 Adh1 Regulation of POMC 1 0.03 0 0.86
162 INT161308 POMC Negative_regulation of Positive_regulation of JUN 1 0.12 0.27 0.86
163 INT5451 CRH Regulation of POMC 2 0.28 0.39 0.85
164 INT161306 POMC Negative_regulation of Transcription of IL2 1 0.24 0.27 0.85
165 INT100283 TXN Negative_regulation of Gene_expression of POMC 1 0.54 0.5 0.85
166 INT32441 POMC Positive_regulation of ELANE 1 0.13 0.09 0.83
167 INT1582 Binding of PENK and POMC 1 0.16 0 0.83
168 INT79617 Htr1a Positive_regulation of Localization of POMC 1 0.38 0 0.83
169 INT19299 ANG Regulation of AVP 1 0.25 0 0.82
170 INT120149 Positive_regulation of Pomc Positive_regulation of Localization of Ins1 1 0.03 0.09 0.82
171 INT128943 Pomc Regulation of Npy 1 0.23 0.61 0.81
172 INT12883 Binding of IL2 and POMC 1 0.01 0 0.81
173 INT107937 POMC Regulation of Gene_expression of TGFBR2 1 0.28 0.82 0.81
174 INT150681 Pomc Positive_regulation of Camk2a 1 0.47 0.07 0.8
175 INT40743 Binding of Gh1 and Pomc 1 0.22 0 0.8
176 INT150680 Pomc Negative_regulation of Gene_expression of Eif2ak3 1 0.35 0.07 0.8
177 INT150679 Pomc Regulation of Gene_expression of Camk2a 1 0.30 0.07 0.79
178 INT240619 Binding of CRP and ADIPOQ 8 0.18 10.74 0.78
179 INT9527 Avp Positive_regulation of Localization of Pomc 7 0.58 0.29 0.77
180 INT18099 POMC Positive_regulation of Binding of Prl 1 0.00 0 0.76
181 INT42929 Pomc Negative_regulation of Localization of Oxt 1 0.11 0 0.76
182 INT107602 Binding of OPLL and Enpp1 1 0.15 1.12 0.76
183 INT29913 Binding of FANCB and Pomc 1 0.01 0 0.76
184 INT113222 POMC Regulation of Gene_expression of MC1R 1 0.06 0 0.76
185 INT32163 Binding of CALM1 and POMC 4 0.46 0 0.75
186 INT164055 POMC Regulation of Agrp 1 0.29 0.3 0.75
187 INT164057 POMC Regulation of Pomc 1 0.09 0.3 0.75
188 INT26982 Cpe Regulation of Localization of Pomc 1 0.01 0 0.75
189 INT41455 Binding of Pomc and Pdyn 1 0.04 0 0.75
190 INT113224 Binding of ASIP and MC1R 1 0.00 0 0.75
191 INT124404 Binding of POMC and Oprm1 1 0.00 0.25 0.75
192 INT164056 Agrp Regulation of POMC 1 0.29 0.3 0.75
193 INT131468 Positive_regulation of POMC Positive_regulation of MC1R 1 0.00 0 0.74
194 INT40826 Pomc Negative_regulation of Binding of Sstr1 1 0.05 0 0.74
195 INT113225 POMC Regulation of Transcription of MC1R 1 0.03 0 0.74
196 INT288371 Binding of Atrn and a 1 0.39 0 0.74
197 INT31642 POMC Regulation of GCG 1 0.41 0.62 0.73
198 INT164052 Agrp Regulation of Pomc 1 0.16 0.29 0.73
199 INT26986 Cpe Regulation of Pomc 1 0.01 0 0.73
200 INT31643 POMC Regulation of INS 1 0.59 0.62 0.73

Single Events

The table below shows the top 100 pain related interactions that have been reported for generation of precursor metabolites and energy. They are ordered first by their pain relevance and then by number of times they were reported in generation of precursor metabolites and energy. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT443 Localization of POMC 1020 0.81 284.52 443.17
2 INT467 Gene_expression of POMC 1048 0.78 332.8 394.16
3 INT720 Positive_regulation of POMC 807 0.70 237.37 353.83
4 INT886 Gene_expression of Pomc 676 0.78 129.87 295.98
5 INT738 Regulation of POMC 459 0.62 111.19 243.74
6 INT1308 Localization of Pomc 457 0.81 66.83 217.5
7 INT2651 Positive_regulation of Pomc 403 0.70 95.72 206.24
8 INT1652 Regulation of Pomc 387 0.62 61.01 186.51
9 INT739 Negative_regulation of POMC 358 0.59 102.28 166.77
10 INT5513 Negative_regulation of Pomc 295 0.59 60.9 158.63
11 INT2640 Gene_expression of Pomc 424 0.78 120.72 155.37
12 INT695 Binding of POMC 304 0.48 56.66 126.85
13 INT6128 Positive_regulation of Localization of POMC 256 0.70 68.77 121.64
14 INT1438 Localization of Pomc 360 0.81 101.26 116.47
15 INT203 Positive_regulation of Pomc 257 0.70 90.56 92.84
16 INT214 Localization of AVP 370 0.81 208.51 91.09
17 INT462 Regulation of Pomc 157 0.62 41.67 67.27
18 INT1437 Negative_regulation of Pomc 132 0.59 35.22 60.97
19 INT1307 Positive_regulation of Localization of Pomc 120 0.70 24.58 58.48
20 INT5453 Regulation of Localization of POMC 114 0.62 20.56 56.34
21 INT1463 Binding of Pomc 129 0.48 15.89 56.27
22 INT5506 Positive_regulation of Gene_expression of Pomc 132 0.70 26.78 54.3
23 INT1197 Negative_regulation of Localization of POMC 109 0.59 28.29 48.02
24 INT683 Positive_regulation of AVP 173 0.70 74.55 46.41
25 INT1295 Binding of Pomc 85 0.48 12.92 42.8
26 INT685 Regulation of AVP 124 0.62 34.9 39.91
27 INT2782 Regulation of Gene_expression of Pomc 75 0.62 15.04 38.97
28 INT1931 Positive_regulation of Gene_expression of POMC 116 0.70 37.26 38.67
29 INT3679 Gene_expression of AVP 171 0.78 72.9 35.23
30 INT6277 Positive_regulation of Gene_expression of Pomc 76 0.70 21.45 31.09
31 INT15347 Positive_regulation of Localization of Pomc 81 0.70 28.1 31.01
32 INT5505 Regulation of Localization of Pomc 54 0.61 6.96 30.77
33 INT1196 Positive_regulation of Positive_regulation of POMC 51 0.70 15.99 28.58
34 INT6174 Regulation of Gene_expression of POMC 49 0.61 9.75 27.69
35 INT7565 Transcription of Pomc 69 0.72 14.46 27.41
36 INT682 Negative_regulation of AVP 97 0.59 50.67 23.91
37 INT2290 Protein_catabolism of POMC 41 0.99 4.86 23.36
38 INT9526 Negative_regulation of Localization of Pomc 41 0.58 6.93 23.3
39 INT55251 Gene_expression of a 142 0.67 81.21 23.03
40 INT5511 Negative_regulation of Gene_expression of Pomc 47 0.59 12.08 23.02
41 INT6127 Regulation of Localization of AVP 60 0.62 15.12 20.84
42 INT11628 Regulation of Localization of Pomc 44 0.61 10.46 18.66
43 INT3118 Negative_regulation of Positive_regulation of POMC 33 0.59 9.42 18.07
44 INT171060 Gene_expression of PDX1 72 0.75 72.57 17.97
45 INT213 Negative_regulation of Localization of AVP 46 0.59 19.78 16.79
46 INT6129 Positive_regulation of Localization of AVP 63 0.70 30.44 16.64
47 INT1416 Transcription of POMC 40 0.72 10.71 15.38
48 INT15643 Positive_regulation of Positive_regulation of Pomc 30 0.65 4.59 15.34
49 INT6278 Negative_regulation of Gene_expression of Pomc 35 0.59 11.07 14.8
50 INT27266 Regulation of Gene_expression of Pomc 41 0.62 6.74 14.59
51 INT6947 Negative_regulation of Gene_expression of POMC 37 0.59 10.32 14.14
52 INT5515 Negative_regulation of Positive_regulation of Pomc 25 0.58 8.73 11.88
53 INT1436 Negative_regulation of Localization of Pomc 41 0.58 10.85 11.26
54 INT8021 Gene_expression of Enpp1 43 0.78 31.46 10.8
55 INT149138 Binding of PDX1 27 0.37 32.62 9.33
56 INT3755 Positive_regulation of GBE1 29 0.40 8.99 8.91
57 INT684 Binding of AVP 38 0.48 13.9 8.85
58 INT44550 Positive_regulation of Gene_expression of AVP 38 0.70 22.27 8.62
59 INT16131 Negative_regulation of GBE1 37 0.30 10.32 8.15
60 INT1591 Negative_regulation of Binding of POMC 18 0.59 1.74 7.91
61 INT298 Negative_regulation of ADRB3 23 0.59 6.82 7.56
62 INT93507 Gene_expression of ASIP 14 0.60 3.98 7.55
63 INT11839 Protein_catabolism of Pomc 15 0.98 0.77 6.99
64 INT50328 Positive_regulation of Vgf 8 0.70 13.98 6.37
65 INT137454 Gene_expression of ADIPOQ 88 0.78 85.32 6.2
66 INT26181 Positive_regulation of Negative_regulation of POMC 12 0.70 1.03 6.14
67 INT32532 Regulation of Positive_regulation of Pomc 11 0.61 3.2 5.93
68 INT27408 Phosphorylation of POMC 9 0.80 2.18 5.88
69 INT224530 Positive_regulation of Enpp1 12 0.70 7.03 5.82
70 INT6276 Negative_regulation of Positive_regulation of Pomc 12 0.57 3.65 5.49
71 INT94652 Binding of a 15 0.48 4.18 5.4
72 INT1755 Gene_expression of GBE1 28 0.26 8.32 5.18
73 INT86475 Binding of ACAA1 7 0.28 1.83 5.11
74 INT14442 Localization of GBE1 19 0.31 9.09 5.03
75 INT80486 Gene_expression of FECH 13 0.54 10.42 4.8
76 INT21254 Regulation of Positive_regulation of POMC 12 0.61 3.64 4.67
77 INT14580 Regulation of Regulation of POMC 8 0.44 1.49 4.63
78 INT24820 Positive_regulation of Binding of POMC 9 0.67 2.98 4.6
79 INT7575 Regulation of Transcription of Pomc 8 0.60 1.57 4.59
80 INT10806 Positive_regulation of Transcription of Pomc 13 0.50 1.74 4.58
81 INT24420 Transcription of Pomc 13 0.69 3.32 4.54
82 INT30444 Negative_regulation of Protein_catabolism of POMC 4 0.51 2.11 4.53
83 INT22337 Negative_regulation of Transcription of Pomc 12 0.59 2.17 4.32
84 INT4104 Gene_expression of ADRB3 19 0.78 2.68 4.12
85 INT19301 Regulation of Regulation of AVP 9 0.45 3.15 4.09
86 INT178261 Positive_regulation of Gene_expression of a 23 0.55 14.67 4.07
87 INT14499 Regulation of Regulation of Pomc 7 0.61 0.15 4.06
88 INT109 Binding of ADRB3 17 0.47 3.02 3.84
89 INT83431 Binding of ADIPOQ 35 0.48 33.63 3.83
90 INT16723 Regulation of GBE1 16 0.11 4.3 3.7
91 INT83433 Positive_regulation of ADIPOQ 40 0.69 34 3.67
92 INT84891 Gene_expression of PPARD 10 0.78 6.8 3.64
93 INT42523 Binding of GBE1 10 0.16 1.03 3.64
94 INT30074 Positive_regulation of Negative_regulation of Pomc 7 0.50 0.99 3.58
95 INT257727 Transcription of Vgf 1 0.72 7.38 3.52
96 INT20408 Regulation of Negative_regulation of Pomc 3 0.45 0.38 3.51
97 INT34678 Regulation of Negative_regulation of Pomc 8 0.62 1.24 3.47
98 INT133214 Regulation of PDX1 9 0.34 10.26 3.36
99 INT68445 Gene_expression of ENPP1 10 0.70 10.8 3.3
100 INT5508 Negative_regulation of Negative_regulation of Pomc 10 0.53 1.57 3.22
101 INT50326 Gene_expression of Vgf 11 0.78 4.41 3.2
102 INT211708 Regulation of a 4 0.42 1.92 3.15
103 INT84890 Negative_regulation of PPARD 7 0.59 3.27 3.1
104 INT32852 Negative_regulation of FECH 18 0.57 10.59 3.08
105 INT313753 Negative_regulation of ACOX1 10 0.45 3.76 3.04
106 INT207851 Regulation of Enpp1 5 0.45 4.42 2.96
107 INT25611 Negative_regulation of Binding of Pomc 6 0.56 1.05 2.74
108 INT171058 Negative_regulation of PDX1 5 0.32 9.31 2.72
109 INT10848 Negative_regulation of Gene_expression of AVP 13 0.59 6.76 2.71
110 INT204340 Localization of ADIPOQ 20 0.75 25.18 2.64
111 INT1586 Regulation of Binding of POMC 7 0.45 1.14 2.61
112 INT50325 Regulation of Vgf 2 0.62 4.4 2.58
113 INT33697 Regulation of Positive_regulation of Pomc 5 0.45 0.83 2.5
114 INT13748 Negative_regulation of Regulation of Pomc 4 0.41 0.63 2.5
115 INT111451 Regulation of ADIPOQ 24 0.56 18.81 2.47
116 INT112974 Gene_expression of Ucp1 12 0.78 7.72 2.45
117 INT46159 Positive_regulation of Positive_regulation of AVP 4 0.50 1.24 2.45
118 INT208898 Gene_expression of FDX1 8 0.10 5.58 2.39
119 INT25438 Positive_regulation of Positive_regulation of Pomc 6 0.48 4 2.37
120 INT243496 Positive_regulation of Gene_expression of FECH 4 0.40 4.02 2.34
121 INT30372 Regulation of ADRB3 8 0.60 0.57 2.24
122 INT107597 Binding of Enpp1 5 0.37 3.35 2.23
123 INT101516 Positive_regulation of PPARD 8 0.49 4.75 2.19
124 INT178246 Negative_regulation of Gene_expression of a 8 0.43 4.27 2.19
125 INT34500 Positive_regulation of ADRB3 12 0.58 2.59 2.16
126 INT46160 Regulation of Positive_regulation of AVP 4 0.53 0.99 2.14
127 INT68865 Gene_expression of ACOX1 13 0.52 5.49 2.09
128 INT178260 Positive_regulation of a 6 0.50 3.09 2.08
129 INT123588 Localization of Vgf 3 0.81 2.35 2.07
130 INT91608 Negative_regulation of ASIP 3 0.40 0.51 2.04
131 INT13294 Negative_regulation of Regulation of Pomc 5 0.38 2.83 2.01
132 INT42497 Regulation of Negative_regulation of POMC 4 0.44 0.63 1.99
133 INT7375 Negative_regulation of Positive_regulation of AVP 6 0.43 0.37 1.97
134 INT316778 Positive_regulation of Gene_expression of ENPP1 1 0.62 7.2 1.97
135 INT25952 Negative_regulation of Regulation of POMC 4 0.36 0.76 1.96
136 INT133269 Positive_regulation of PDX1 10 0.54 9.77 1.9
137 INT171059 Localization of PDX1 8 0.56 6.7 1.9
138 INT53567 Positive_regulation of FECH 14 0.45 11.03 1.82
139 INT88269 Binding of ASIP 4 0.19 0.41 1.82
140 INT224529 Positive_regulation of Gene_expression of Enpp1 15 0.70 12.75 1.81
141 INT41580 Negative_regulation of Negative_regulation of POMC 5 0.50 0.46 1.79
142 INT6246 Negative_regulation of Negative_regulation of Pomc 3 0.43 1.34 1.78
143 INT6722 Regulation of Binding of Pomc 4 0.45 0.17 1.75
144 INT6130 Positive_regulation of Regulation of POMC 6 0.69 3.57 1.7
145 INT89008 Gene_expression of Lepr 2 0.65 5.39 1.66
146 INT119896 Negative_regulation of Gene_expression of Ucp1 4 0.58 2.36 1.57
147 INT43482 Regulation of Binding of ADRB3 4 0.60 1.06 1.54
148 INT33245 Negative_regulation of Binding of Pomc 6 0.52 0 1.52
149 INT17094 Negative_regulation of SLC25A4 3 0.41 3.82 1.52
150 INT332460 Regulation of Binding of Enpp1 1 0.05 0.78 1.5
151 INT84889 Positive_regulation of Gene_expression of PPARD 4 0.70 2.94 1.49
152 INT188241 Negative_regulation of ADIPOQ 16 0.43 22.16 1.47
153 INT84888 Binding of PPARD 5 0.48 2.82 1.45
154 INT32575 Negative_regulation of Protein_catabolism of Pomc 1 0.41 0.18 1.42
155 INT10852 Transcription of AVP 3 0.69 1.75 1.41
156 INT178249 Regulation of Gene_expression of a 4 0.35 2.3 1.39
157 INT5466 Positive_regulation of Negative_regulation of ADRB3 2 0.44 0.17 1.39
158 INT32805 Regulation of Regulation of Pomc 2 0.42 0.1 1.35
159 INT23693 Positive_regulation of Protein_catabolism of Pomc 1 0.38 0 1.35
160 INT39580 Positive_regulation of Regulation of Pomc 3 0.49 0 1.33
161 INT40102 Positive_regulation of Phosphorylation of POMC 3 0.44 0.57 1.3
162 INT183065 Positive_regulation of Gene_expression of PDX1 7 0.54 6.58 1.29
163 INT107599 Negative_regulation of Enpp1 8 0.51 6.02 1.24
164 INT118258 Positive_regulation of ENPP1 3 0.62 4.26 1.16
165 INT213277 Positive_regulation of Gene_expression of ADIPOQ 14 0.50 17.7 1.14
166 INT158469 Regulation of FECH 3 0.36 1.76 1.13
167 INT115264 Binding of FECH 9 0.41 7.93 1.1
168 INT178255 Localization of a 4 0.65 0.72 1.1
169 INT54794 Binding of Lepr 1 0.01 0 1.07
170 INT34490 Negative_regulation of Localization of GBE1 3 0.01 2.08 1.02
171 INT33048 Positive_regulation of Protein_catabolism of POMC 1 0.04 0 1.02
172 INT208896 Regulation of FDX1 1 0.09 1.2 0.99
173 INT178252 Transcription of a 3 0.67 0.73 0.9
174 INT25539 Regulation of Gene_expression of AVP 9 0.45 2.74 0.89
175 INT123589 Positive_regulation of Positive_regulation of Vgf 7 0.50 2.92 0.88
176 INT162073 Negative_regulation of Transcription of POMC 1 0.34 0.34 0.88
177 INT68866 Positive_regulation of ACOX1 4 0.31 4.98 0.87
178 INT131007 Positive_regulation of Transcription of Pomc 2 0.49 1.68 0.86
179 INT51704 Phosphorylation of AVP 2 0.79 0.33 0.86
180 INT51703 Positive_regulation of Phosphorylation of AVP 1 0.49 0.09 0.86
181 INT84892 Negative_regulation of Gene_expression of PPARD 2 0.43 1.85 0.83
182 INT145073 Regulation of Gene_expression of ASIP 1 0.27 0 0.83
183 INT142016 Negative_regulation of Gene_expression of CEBPA 1 0.41 0.67 0.8
184 INT142018 Gene_expression of CEBPA 1 0.75 0.66 0.8
185 INT118986 Positive_regulation of Gene_expression of ASIP 1 0.39 0.97 0.8
186 INT55560 Binding of SLC25A4 8 0.36 1.94 0.79
187 INT1852 Localization of ADRB3 3 0.75 1.02 0.79
188 INT149604 Regulation of Negative_regulation of AVP 2 0.44 0.49 0.77
189 INT18229 Positive_regulation of Regulation of Pomc 2 0.44 0.15 0.76
190 INT50329 Positive_regulation of Gene_expression of Vgf 2 0.70 3.45 0.75
191 INT30280 Phosphorylation of Pomc 2 0.16 0.13 0.73
192 INT35098 Localization of Enpp1 4 0.75 0.81 0.67
193 INT257721 Regulation of Gene_expression of Vgf 1 0.27 0.79 0.67
194 INT143742 Positive_regulation of Gene_expression of GBE1 2 0.20 0.36 0.66
195 INT63891 Negative_regulation of Ucp1 4 0.51 1.96 0.63
196 INT172204 Gene_expression of SLC25A4 8 0.70 4.11 0.62
197 INT3690 Protein_catabolism of Pomc 6 0.96 0.6 0.6
198 INT245633 Negative_regulation of FDX1 3 0.10 1.39 0.6
199 INT46231 Regulation of Protein_catabolism of POMC 1 0.05 0 0.6
200 INT257724 Positive_regulation of Localization of Vgf 1 0.70 0.64 0.59
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