GO:0006099

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Name tricarboxylic acid cycle
Categary Process
Go Slim No
Go Link GO:0006099
Unique Molecular Interactions 99
Total Molecular Interactions 120
Total Single Events 785
Pain Genes Associated 18

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for tricarboxylic acid cycle. They are ordered first by their pain relevance and then by number of times they were reported for tricarboxylic acid cycle. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT351246 Binding of OPN1LW and NNT 1 0.03 0.53 1.45
2 INT127133 Positive_regulation of OPRM1 Positive_regulation of Protein_catabolism of SUCLG2 1 0.20 0.2 1.1
3 INT34241 Dlst Positive_regulation of Positive_regulation of LH 1 0.28 0 0.77
4 INT78663 Dlst Regulation of Nos1 1 0.19 0.91 0.65
5 INT137099 Dlst Regulation of Sec22b 1 0.05 0 0.64
6 INT137100 Dlst Regulation of Htr1a 1 0.18 0 0.64
7 INT34239 Dlst Regulation of Positive_regulation of LH 1 0.27 0 0.57
8 INT34242 Dlst Regulation of Localization of LH 1 0.43 0 0.55
9 INT122838 Mdh1 Positive_regulation of Tst 1 0.78 0.4 0.55
10 INT125574 CS Regulation of Ldha 1 0.02 0.23 0.42
11 INT17059 Binding of DLD and Oxt 1 0.03 0.22 0.41
12 INT272052 Binding of CS and Cfcd 1 0.00 0.54 0.4
13 INT308889 Binding of Idh1 and Adp 1 0.02 0 0.36
14 INT308890 Binding of Idh1 and P2ry13 1 0.06 0 0.35
15 INT241742 Negative_regulation of Sdhb Regulation of Rapgef5 1 0.02 0.39 0.33
16 INT241740 Sdhb Regulation of Rapgef5 1 0.02 0.34 0.32
17 INT241739 Sdhb Regulation of Adora2b 1 0.04 0.63 0.31
18 INT266800 Dlst Positive_regulation of Localization of VEGFA 1 0.02 0.88 0.29
19 INT5933 Dlst Regulation of Oprm1 1 0.09 0.51 0.28
20 INT39299 Binding of Prl and Dlst 1 0.20 0 0.27
21 INT266803 Dlst Positive_regulation of VEGFA 1 0.01 0.96 0.25
22 INT266802 Dlst Positive_regulation of CCL5 1 0.00 0.95 0.25
23 INT266801 Dlst Positive_regulation of IL8 1 0.00 0.95 0.25
24 INT156661 Binding of Pgls and Sdhb 1 0.01 1.43 0.25
25 INT52459 Binding of SUCLA2 and HEY2 1 0.01 0.09 0.21
26 INT78662 Dlst Positive_regulation of Gene_expression of Nos1 1 0.20 0.17 0.14
27 INT117371 SUCLA2 Positive_regulation of Localization of INS 1 0.03 0 0.13
28 INT117372 SUCLA2 Regulation of Localization of INS 1 0.02 0 0.13
29 INT35374 Dlst Positive_regulation of Tk1 1 0.02 0.26 0.11
30 INT35373 Negative_regulation of Dlst Positive_regulation of Tk1 1 0.02 0.27 0.11
31 INT200213 PAH Positive_regulation of SDHD 1 0.21 2.43 0.1
32 INT281881 Binding of Aco1 and Ros1 1 0.01 1.93 0.1
33 INT197914 Dlst Positive_regulation of Positive_regulation of S100g 1 0.06 0 0.1
34 INT244452 CS Positive_regulation of Phosphorylation of EIF2S2 1 0.21 2.07 0.09
35 INT241741 Sdhb Positive_regulation of Transcription of Adora2b 1 0.07 0.28 0.08
36 INT244449 CS Regulation of Gene_expression of ATF4 1 0.15 0.83 0.08
37 INT76965 Mpo Negative_regulation of DLD 1 0.26 0.91 0.07
38 INT239186 H2 Negative_regulation of Aco1 1 0.00 1.96 0.05
39 INT310321 DLD Negative_regulation of COQ10A 1 0.01 0.06 0.05
40 INT244461 CS Positive_regulation of ESR1 1 0.06 1.15 0.05
41 INT204172 Regulation of Binding of Cs and Nox1 1 0.08 1.01 0.04
42 INT204173 Binding of Cs and Nox1 1 0.07 1 0.04
43 INT24466 Binding of Dlst and Foxp4 1 0.00 0 0.03
44 INT218964 Dlst Regulation of AR 1 0.01 0 0.03
45 INT197903 Dlst Positive_regulation of S100g 1 0.04 0 0
46 INT244474 CS Regulation of XBP1 1 0.20 0.15 0
47 INT241120 Binding of Sdhc and Sdhd 1 0.00 1.28 0
48 INT218963 Dlst Negative_regulation of AR 1 0.00 0.1 0
49 INT244480 CS Negative_regulation of Gene_expression of XBP1 1 0.16 0.11 0
50 INT218952 Dlst Negative_regulation of Igf1 1 0.03 0.1 0
51 INT244476 CS Positive_regulation of ATF3 1 0.13 0.13 0
52 INT64385 Cs Negative_regulation of PGC 1 0.00 0.15 0
53 INT244469 CS Positive_regulation of PPP1R15A 1 0.08 0.12 0
54 INT218976 Dlst Positive_regulation of Gene_expression of PCNA 1 0.05 0.06 0
55 INT244457 CS Positive_regulation of Gene_expression of ESR1 1 0.07 0.67 0
56 INT244458 CS Positive_regulation of ERN1 1 0.17 0.71 0
57 INT244475 Binding of CS and Positive_regulation of EIF2S2 1 0.11 0.07 0
58 INT218954 Dlst Regulation of Gene_expression of Igf1 1 0.03 0 0
59 INT197907 Dlst Regulation of S100a6 1 0.10 0 0
60 INT197911 Dlst Positive_regulation of Gene_expression of Esr1 1 0.03 0.34 0
61 INT241119 Binding of Sdhc and Sdhb 1 0.00 1.29 0
62 INT197908 Dlst Positive_regulation of Esr1 1 0.03 0.34 0
63 INT315541 ACO1 Negative_regulation of Gene_expression of ALAS2 1 0.17 0.18 0
64 INT310231 INS Negative_regulation of Binding of SUCLA2 1 0.06 0.46 0
65 INT218951 Negative_regulation of Dlst Negative_regulation of Igf1 1 0.03 0.1 0
66 INT315534 Binding of ACO1 and ERN1 1 0.01 0.18 0
67 INT197899 Dlst Positive_regulation of Ldha 1 0.04 0.34 0
68 INT252807 Binding of ACO1 and TFRC 1 0.01 1.83 0
69 INT197912 Dlst Positive_regulation of Gene_expression of Pgr 1 0.01 0.34 0
70 INT336179 Binding of CACNA1F and DLST 1 0.01 1.6 0
71 INT244477 CS Regulation of Gene_expression of ATF6 1 0.18 0.07 0
72 INT197904 Dlst Positive_regulation of Positive_regulation of S100a6 1 0.09 0 0
73 INT244453 CS Positive_regulation of Gene_expression of TMBIM6 1 0.07 1.3 0
74 INT244479 CS Positive_regulation of ATF6 1 0.17 1.02 0
75 INT244460 Binding of CS and Positive_regulation of Positive_regulation of EIF2S2 1 0.13 0.06 0
76 INT197898 Dlst Regulation of Gene_expression of S100a6 1 0.14 0 0
77 INT176919 Binding of DLD and Bpifa2 1 0.00 0.08 0
78 INT310230 INS Negative_regulation of Localization of SUCLA2 1 0.07 1.09 0
79 INT244468 CS Positive_regulation of EIF2S2 1 0.16 0.43 0
80 INT244467 Negative_regulation of CS Positive_regulation of EIF2S2 1 0.11 0.14 0
81 INT218962 Dlst Regulation of Gene_expression of AR 1 0.01 0 0
82 INT244478 Regulation of CS Regulation of XBP1 1 0.20 0.06 0
83 INT176920 DLD Positive_regulation of Binding of Bpifa2 1 0.00 0.08 0
84 INT244482 CS Positive_regulation of Transcription of ATF3 1 0.13 0.13 0
85 INT244472 CS Negative_regulation of Binding of XBP1 1 0.19 1.07 0
86 INT310229 Binding of INS and SUCLA2 1 0.07 4.69 0
87 INT218975 Dlst Negative_regulation of Gnrh1 1 0.16 0.16 0
88 INT281880 Binding of Aco1 and Cish 1 0.00 0.16 0
89 INT92728 Dlst Positive_regulation of Pomc 1 0.19 0 0
90 INT197906 Dlst Positive_regulation of Gene_expression of Ldha 1 0.03 0.31 0
91 INT354469 Binding of SDHC and Sdhb 1 0.08 1.82 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for tricarboxylic acid cycle. They are ordered first by their pain relevance and then by number of times they were reported in tricarboxylic acid cycle. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT11150 Positive_regulation of Dlst 31 0.51 9.01 6.63
2 INT17056 Gene_expression of DLD 37 0.57 13.15 5.47
3 INT200218 Localization of SDHD 1 0.69 48.58 4.57
4 INT10594 Gene_expression of Dlst 33 0.57 6 3.38
5 INT24309 Binding of Sdhb 2 0.36 0.98 3.03
6 INT12796 Binding of DLD 20 0.36 6.71 3.02
7 INT120201 Gene_expression of Aco1 54 0.35 26.29 2.95
8 INT7142 Positive_regulation of DLD 22 0.60 7.69 2.76
9 INT53447 Negative_regulation of DLD 17 0.54 12.9 2.48
10 INT26363 Negative_regulation of CS 8 0.26 2.49 2.36
11 INT127141 Negative_regulation of SUCLG2 1 0.49 0.57 2.34
12 INT110038 Negative_regulation of Aco1 26 0.23 17.41 2.2
13 INT24307 Transcription of Sdhb 1 0.26 0 2.11
14 INT35109 Binding of SUCLA2 6 0.32 5.79 2.01
15 INT24464 Binding of Dlst 8 0.29 0.52 1.99
16 INT281878 Positive_regulation of Gene_expression of Aco1 35 0.31 17.15 1.98
17 INT43926 Gene_expression of SUCLA2 6 0.65 5.01 1.93
18 INT35370 Negative_regulation of Dlst 6 0.32 2.58 1.9
19 INT26364 Positive_regulation of CS 12 0.30 4.99 1.89
20 INT17452 Regulation of Dlst 14 0.46 1.5 1.68
21 INT17453 Localization of Dlst 20 0.59 4.54 1.46
22 INT52130 Regulation of SUCLA2 2 0.44 1.75 1.36
23 INT74550 Negative_regulation of SUCLA2 5 0.41 3.6 1.24
24 INT121561 Negative_regulation of Binding of Sdhb 1 0.41 0.74 1.2
25 INT127140 Negative_regulation of Negative_regulation of SUCLG2 1 0.36 0.28 1.19
26 INT202218 Positive_regulation of Aco1 4 0.27 12.31 1.06
27 INT125573 Gene_expression of CS 26 0.41 8 0.98
28 INT61613 Regulation of DLD 6 0.34 2.96 0.92
29 INT127138 Positive_regulation of Protein_catabolism of SUCLG2 1 0.42 0.2 0.92
30 INT127142 Protein_catabolism of SUCLG2 1 0.83 0.2 0.92
31 INT171435 Gene_expression of SDHD 14 0.58 26.55 0.91
32 INT52460 Localization of SUCLA2 5 0.67 2.5 0.86
33 INT200222 Positive_regulation of Localization of SDHD 1 0.43 7.07 0.84
34 INT9368 Regulation of CS 6 0.17 1.67 0.8
35 INT48909 Localization of DLD 9 0.63 3.37 0.75
36 INT200216 Binding of SDHD 3 0.37 4.51 0.71
37 INT90022 Gene_expression of SUCLG2 1 0.00 0 0.68
38 INT34235 Positive_regulation of Positive_regulation of Dlst 2 0.26 0.25 0.65
39 INT169779 Positive_regulation of Sdhb 4 0.67 1.2 0.64
40 INT107119 Positive_regulation of Idh1 1 0.36 0.42 0.63
41 INT70314 Positive_regulation of SUCLA2 5 0.10 3.91 0.58
42 INT169780 Gene_expression of Sdhb 2 0.65 0.69 0.54
43 INT55594 Negative_regulation of Positive_regulation of DLD 1 0.02 0.62 0.53
44 INT77707 Negative_regulation of Mdh1 1 0.41 0.83 0.52
45 INT78661 Positive_regulation of Gene_expression of Dlst 4 0.24 1.23 0.51
46 INT197071 Regulation of Localization of Dlst 1 0.46 1.06 0.47
47 INT257906 Positive_regulation of Mdh1 1 0.20 0.7 0.44
48 INT23650 Positive_regulation of Sdhb 2 0.17 1.34 0.43
49 INT212652 Gene_expression of SDHC 1 0.40 0.73 0.43
50 INT200221 Positive_regulation of SDHD 3 0.43 6.59 0.42
51 INT241723 Positive_regulation of Gene_expression of Sdhb 1 0.06 0.51 0.38
52 INT205274 Gene_expression of Cs 2 0.75 2.08 0.36
53 INT308876 Binding of Idh1 2 0.23 0.77 0.35
54 INT140116 Binding of Sdhd 2 0.04 2.78 0.3
55 INT156656 Gene_expression of Sdhb 1 0.05 1.57 0.3
56 INT284123 Binding of DLST 2 0.32 2.3 0.29
57 INT155170 Negative_regulation of Localization of SUCLA2 2 0.38 1.26 0.28
58 INT116953 Positive_regulation of SUCLG2 1 0.01 0.16 0.27
59 INT95758 Negative_regulation of ACO1 2 0.51 1.25 0.26
60 INT169777 Positive_regulation of Positive_regulation of Sdhb 1 0.58 0.24 0.26
61 INT258490 Gene_expression of NNT 1 0.31 0.27 0.24
62 INT281874 Localization of Aco1 1 0.32 3.67 0.23
63 INT205532 Binding of CS 7 0.14 1.27 0.22
64 INT281876 Regulation of Aco1 4 0.11 4 0.22
65 INT310950 Gene_expression of DLST 3 0.58 3.03 0.22
66 INT135644 Binding of Aco1 2 0.19 2.6 0.22
67 INT35369 Negative_regulation of Gene_expression of Dlst 2 0.05 0.7 0.21
68 INT95760 Negative_regulation of Gene_expression of ACO1 1 0.00 0.93 0.2
69 INT149200 Binding of SDHC 2 0.36 1.82 0.18
70 INT128120 Transcription of DLD 1 0.67 0 0.18
71 INT52131 Negative_regulation of Regulation of SUCLA2 1 0.32 0 0.17
72 INT43708 Negative_regulation of Binding of DLD 1 0.35 0.17 0.17
73 INT318162 Localization of NNT 1 0.65 0.16 0.16
74 INT147951 Gene_expression of Idh1 1 0.11 0.34 0.16
75 INT200215 Transcription of SDHD 1 0.59 1.35 0.15
76 INT244569 Phosphorylation of CS 1 0.31 2.96 0.15
77 INT197867 Negative_regulation of Binding of Dlst 1 0.10 0 0.14
78 INT90231 Regulation of Idh1 1 0.02 0.1 0.13
79 INT90230 Transcription of Idh1 1 0.03 0.1 0.13
80 INT238021 Negative_regulation of NNT 1 0.04 0.39 0.13
81 INT281872 Positive_regulation of Positive_regulation of Aco1 1 0.20 1.3 0.12
82 INT197069 Positive_regulation of Localization of Dlst 1 0.51 0 0.12
83 INT83129 Protein_catabolism of DLD 1 0.02 0 0.12
84 INT197070 Negative_regulation of Localization of Dlst 1 0.32 0 0.12
85 INT244487 Regulation of Positive_regulation of CS 1 0.10 0.18 0.12
86 INT108344 Regulation of Sdhb 1 0.29 1.34 0.11
87 INT131139 Binding of ACO1 3 0.27 1.81 0.1
88 INT95756 Gene_expression of ACO1 3 0.27 2.49 0.1
89 INT244553 Positive_regulation of Gene_expression of CS 6 0.22 3.07 0.09
90 INT131140 Negative_regulation of Negative_regulation of ACO1 1 0.37 0.58 0.09
91 INT336476 Positive_regulation of Binding of CS 1 0.09 0 0.09
92 INT137756 Regulation of Negative_regulation of DLD 1 0.02 0.09 0.09
93 INT171434 Positive_regulation of Gene_expression of SDHD 2 0.10 3.87 0.08
94 INT262774 Negative_regulation of DLST 1 0.23 0.43 0.07
95 INT197068 Regulation of Regulation of Dlst 1 0.33 0.24 0.07
96 INT318160 Binding of NNT 1 0.32 0.14 0.07
97 INT205533 Localization of CS 4 0.28 0.69 0.06
98 INT310951 Positive_regulation of DLST 2 0.43 2.71 0.06
99 INT241727 Positive_regulation of Transcription of Sdhb 1 0.06 0.28 0.06
100 INT160824 Transcription of SUCLA2 1 0.04 1.27 0.06
101 INT160820 Positive_regulation of Transcription of SUCLA2 1 0.03 1.28 0.06
102 INT160819 Regulation of Transcription of SUCLA2 1 0.02 1.28 0.06
103 INT244341 Regulation of Binding of DLD 1 0.30 0.19 0.06
104 INT239158 Negative_regulation of Positive_regulation of Aco1 2 0.17 1.26 0.05
105 INT241732 Transcription of Sdhb 1 0.08 0.28 0.05
106 INT281875 Negative_regulation of Gene_expression of Aco1 1 0.17 0.48 0.05
107 INT244536 Negative_regulation of Gene_expression of CS 3 0.31 0.88 0.04
108 INT204165 Regulation of Cs 2 0.09 1.35 0.04
109 INT281877 Regulation of Localization of Aco1 1 0.18 1.36 0.04
110 INT281871 Positive_regulation of Localization of Aco1 1 0.20 1.37 0.04
111 INT241718 Binding of Sdhb 1 0.05 0 0.04
112 INT241731 Localization of Sdhb 1 0.09 0 0.04
113 INT241729 Positive_regulation of Localization of Sdhb 1 0.06 0 0.04
114 INT244518 Positive_regulation of Localization of CS 2 0.19 0.37 0.03
115 INT218946 Regulation of Protein_catabolism of Dlst 1 0.05 0.17 0.03
116 INT218950 Protein_catabolism of Dlst 1 0.11 0.17 0.03
117 INT310235 Regulation of Gene_expression of SUCLA2 1 0.09 0.25 0
118 INT244530 Regulation of Binding of CS 1 0.17 0.06 0
119 INT343776 Regulation of Gene_expression of SDHD 1 0.00 0.16 0
120 INT315623 Positive_regulation of Localization of ACO1 1 0.20 0.79 0
121 INT183747 Positive_regulation of NNT 1 0.44 0.63 0
122 INT217416 Positive_regulation of Positive_regulation of DLD 1 0.42 0.19 0
123 INT315588 Regulation of ACO1 1 0.18 0.57 0
124 INT310952 Localization of DLST 1 0.64 0.82 0
125 INT183746 Positive_regulation of Positive_regulation of NNT 1 0.29 0.63 0
126 INT221520 Negative_regulation of Gene_expression of DLD 1 0.04 0.27 0
127 INT323587 Transcription of Aco1 1 0.03 0.1 0
128 INT218944 Regulation of Gene_expression of Dlst 1 0.05 0 0
129 INT336196 Negative_regulation of Gene_expression of DLST 1 0.07 1.03 0
130 INT310237 Negative_regulation of Binding of SUCLA2 1 0.09 0.61 0
131 INT344633 Negative_regulation of Cs 1 0.42 0.82 0
132 INT244565 Negative_regulation of Phosphorylation of CS 1 0.16 0.24 0
133 INT252749 Regulation of Gene_expression of ACO1 1 0.02 0.9 0
134 INT315574 Localization of ACO1 1 0.30 0.79 0
135 INT348738 Gene_expression of Mdh1 1 0.51 0.53 0
136 INT318161 Regulation of Binding of NNT 1 0.39 0 0
137 INT315616 Positive_regulation of Gene_expression of ACO1 1 0.20 0.79 0
138 INT315572 Positive_regulation of ACO1 1 0.20 0.94 0
139 INT323585 Regulation of Transcription of Aco1 1 0.02 0.1 0
140 INT348741 Positive_regulation of Gene_expression of Mdh1 1 0.40 0.11 0
141 INT310233 Positive_regulation of Positive_regulation of SUCLA2 1 0.10 0.87 0
142 INT244515 Regulation of Gene_expression of CS 1 0.20 1.26 0
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