GO:0006101

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Name citrate metabolic process
Categary Process
Go Slim No
Go Link GO:0006101
Unique Molecular Interactions 60
Total Molecular Interactions 88
Total Single Events 845
Pain Genes Associated 14

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for citrate metabolic process. They are ordered first by their pain relevance and then by number of times they were reported for citrate metabolic process. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT69823 Binding of GHR and RYBP 1 0.01 0 3.23
2 INT69824 Negative_regulation of Binding of GHR and RYBP 1 0.01 0 1.14
3 INT45279 Binding of CSF2 and GHR 1 0.05 0.07 0.93
4 INT167944 Binding of Oprm1 and Stat5a 1 0.00 0 0.85
5 INT73775 Binding of GH1 and GHR 4 0.35 0.68 0.8
6 INT73776 Regulation of Binding of GH1 and GHR 2 0.26 0.16 0.75
7 INT126614 Ppyr1 Negative_regulation of Phosphorylation of Stat5a 1 0.27 0.1 0.64
8 INT126615 Binding of Oprd1 and Stat5a 1 0.28 0.07 0.61
9 INT184130 Epo Positive_regulation of Stat5a 1 0.31 0.26 0.52
10 INT184096 Il7 Positive_regulation of Stat5a 1 0.07 0.26 0.51
11 INT184132 Il2 Positive_regulation of Stat5a 1 0.09 0.26 0.51
12 INT125574 CS Regulation of Ldha 1 0.02 0.23 0.42
13 INT272052 Binding of CS and Cfcd 1 0.00 0.54 0.4
14 INT167946 Binding of SRC and Stat5b 1 0.28 0 0.38
15 INT245590 Ghr Positive_regulation of Gene_expression of Igf1 1 0.34 0.61 0.23
16 INT242094 Binding of ACLY and Pts 1 0.01 0 0.22
17 INT194576 Binding of ACLY and CD40LG 1 0.07 0.07 0.14
18 INT184129 Socs2 Negative_regulation of Stat5a 1 0.22 0.05 0.13
19 INT184089 Gh Positive_regulation of Stat5b 1 0.13 1.3 0.1
20 INT281881 Binding of Aco1 and Ros1 1 0.01 1.93 0.1
21 INT244452 CS Positive_regulation of Phosphorylation of EIF2S2 1 0.21 2.07 0.09
22 INT244449 CS Regulation of Gene_expression of ATF4 1 0.15 0.83 0.08
23 INT353912 Binding of ACLY and LARS 1 0.25 0.28 0.06
24 INT239186 H2 Negative_regulation of Aco1 1 0.00 1.96 0.05
25 INT244461 CS Positive_regulation of ESR1 1 0.06 1.15 0.05
26 INT204172 Regulation of Binding of Cs and Nox1 1 0.08 1.01 0.04
27 INT268798 Binding of Gh and Ghr 1 0.26 1.18 0.04
28 INT204173 Binding of Cs and Nox1 1 0.07 1 0.04
29 INT313618 Binding of Acly and Pdgfb 1 0.00 0.18 0.03
30 INT265881 GHRH Positive_regulation of GHR 1 0.05 0.05 0.03
31 INT244474 CS Regulation of XBP1 1 0.20 0.15 0
32 INT353192 Stat5a Positive_regulation of Plxna3 1 0.01 0 0
33 INT244480 CS Negative_regulation of Gene_expression of XBP1 1 0.16 0.11 0
34 INT244476 CS Positive_regulation of ATF3 1 0.13 0.13 0
35 INT64385 Cs Negative_regulation of PGC 1 0.00 0.15 0
36 INT244469 CS Positive_regulation of PPP1R15A 1 0.08 0.12 0
37 INT173769 Dlat Regulation of Ghr 1 0.04 0 0
38 INT317769 Binding of Nfe2l2 and Acly 1 0.22 0.08 0
39 INT244457 CS Positive_regulation of Gene_expression of ESR1 1 0.07 0.67 0
40 INT244458 CS Positive_regulation of ERN1 1 0.17 0.71 0
41 INT244475 Binding of CS and Positive_regulation of EIF2S2 1 0.11 0.07 0
42 INT317768 Nfe2l2 Regulation of Acly 1 0.38 0.25 0
43 INT315541 ACO1 Negative_regulation of Gene_expression of ALAS2 1 0.17 0.18 0
44 INT315534 Binding of ACO1 and ERN1 1 0.01 0.18 0
45 INT252807 Binding of ACO1 and TFRC 1 0.01 1.83 0
46 INT216465 Gh Positive_regulation of Ghr 1 0.26 0.23 0
47 INT247003 Binding of Ghr and Gh1 1 0.00 0 0
48 INT244477 CS Regulation of Gene_expression of ATF6 1 0.18 0.07 0
49 INT244453 CS Positive_regulation of Gene_expression of TMBIM6 1 0.07 1.3 0
50 INT244479 CS Positive_regulation of ATF6 1 0.17 1.02 0
51 INT244460 Binding of CS and Positive_regulation of Positive_regulation of EIF2S2 1 0.13 0.06 0
52 INT353190 Stat5a Positive_regulation of Cyp2c11 1 0.31 0 0
53 INT244468 CS Positive_regulation of EIF2S2 1 0.16 0.43 0
54 INT244467 Negative_regulation of CS Positive_regulation of EIF2S2 1 0.11 0.14 0
55 INT244478 Regulation of CS Regulation of XBP1 1 0.20 0.06 0
56 INT244482 CS Positive_regulation of Transcription of ATF3 1 0.13 0.13 0
57 INT244472 CS Negative_regulation of Binding of XBP1 1 0.19 1.07 0
58 INT281880 Binding of Aco1 and Cish 1 0.00 0.16 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for citrate metabolic process. They are ordered first by their pain relevance and then by number of times they were reported in citrate metabolic process. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT78024 Gene_expression of ACLY 73 0.75 59.15 18.54
2 INT35584 Binding of ACLY 22 0.35 31.78 7.17
3 INT9895 Binding of GHR 18 0.36 4.8 5.65
4 INT126608 Binding of Stat5a 7 0.48 0.46 4.38
5 INT95512 Transcription of Ghr 24 0.69 3.1 4.12
6 INT77670 Positive_regulation of ACLY 24 0.49 21.68 3.12
7 INT59905 Gene_expression of Ghr 29 0.63 9.25 2.97
8 INT120201 Gene_expression of Aco1 54 0.35 26.29 2.95
9 INT126610 Phosphorylation of Stat5a 5 0.82 0.8 2.52
10 INT22019 Regulation of GHR 9 0.62 2.56 2.39
11 INT26363 Negative_regulation of CS 8 0.26 2.49 2.36
12 INT16286 Positive_regulation of GHR 8 0.60 4.04 2.31
13 INT67352 Transcription of Ghr 8 0.61 1.55 2.3
14 INT110038 Negative_regulation of Aco1 26 0.23 17.41 2.2
15 INT95510 Regulation of Ghr 1 0.45 0.21 2.07
16 INT4643 Negative_regulation of GHR 10 0.45 3.01 2
17 INT281878 Positive_regulation of Gene_expression of Aco1 35 0.31 17.15 1.98
18 INT26364 Positive_regulation of CS 12 0.30 4.99 1.89
19 INT126609 Positive_regulation of Phosphorylation of Stat5a 1 0.69 0.26 1.79
20 INT75316 Gene_expression of Ghr 6 0.78 1.24 1.68
21 INT28300 Gene_expression of GHR 10 0.78 4.29 1.5
22 INT67348 Negative_regulation of Ghr 8 0.40 2.84 1.43
23 INT181868 Localization of ACLY 5 0.62 6.36 1.4
24 INT75315 Regulation of Ghr 4 0.22 1.5 1.34
25 INT126605 Negative_regulation of Binding of Stat5a 1 0.58 0.15 1.27
26 INT95511 Negative_regulation of Transcription of Ghr 1 0.43 0 1.15
27 INT61512 Regulation of Binding of GHR 2 0.05 0.89 1.1
28 INT202218 Positive_regulation of Aco1 4 0.27 12.31 1.06
29 INT95514 Negative_regulation of Ghr 3 0.36 1.3 0.99
30 INT125573 Gene_expression of CS 26 0.41 8 0.98
31 INT69132 Negative_regulation of ACLY 5 0.42 2.95 0.92
32 INT95507 Negative_regulation of Gene_expression of Ghr 3 0.33 0.49 0.91
33 INT184015 Positive_regulation of Stat5a 9 0.46 3.32 0.86
34 INT216456 Positive_regulation of Ghr 6 0.41 4.96 0.85
35 INT167938 Positive_regulation of Phosphorylation of Stat5b 1 0.33 0 0.85
36 INT167942 Binding of Stat5b 1 0.26 0 0.82
37 INT9368 Regulation of CS 6 0.17 1.67 0.8
38 INT111199 Gene_expression of Acly 11 0.16 5.65 0.78
39 INT245584 Positive_regulation of Gene_expression of Ghr 5 0.41 3.46 0.75
40 INT73783 Regulation of Gene_expression of GHR 1 0.45 0 0.7
41 INT126606 Negative_regulation of Stat5a 1 0.43 0.08 0.64
42 INT159942 Positive_regulation of Stat5a 3 0.41 0.95 0.61
43 INT126612 Negative_regulation of Phosphorylation of Stat5a 1 0.42 0.1 0.61
44 INT95506 Negative_regulation of Transcription of Ghr 1 0.15 0 0.6
45 INT205905 Gene_expression of Acly 4 0.59 0.37 0.59
46 INT95508 Negative_regulation of Gene_expression of Ghr 1 0.59 0 0.56
47 INT167941 Phosphorylation of Stat5b 1 0.58 0 0.42
48 INT173752 Positive_regulation of Ghr 3 0.57 2.21 0.41
49 INT82331 Positive_regulation of Positive_regulation of GHR 1 0.00 0.06 0.4
50 INT119001 Regulation of ACLY 5 0.44 4.83 0.36
51 INT205274 Gene_expression of Cs 2 0.75 2.08 0.36
52 INT205897 Positive_regulation of Gene_expression of Acly 1 0.53 0.09 0.36
53 INT28299 Negative_regulation of Gene_expression of GHR 1 0.03 0.1 0.35
54 INT67350 Binding of Ghr 9 0.43 1.83 0.28
55 INT145256 Binding of Acly 2 0.07 1.17 0.27
56 INT95758 Negative_regulation of ACO1 2 0.51 1.25 0.26
57 INT67349 Localization of Ghr 6 0.66 2.53 0.23
58 INT67351 Positive_regulation of Localization of Ghr 2 0.44 0.78 0.23
59 INT281874 Localization of Aco1 1 0.32 3.67 0.23
60 INT205532 Binding of CS 7 0.14 1.27 0.22
61 INT281876 Regulation of Aco1 4 0.11 4 0.22
62 INT135644 Binding of Aco1 2 0.19 2.6 0.22
63 INT95760 Negative_regulation of Gene_expression of ACO1 1 0.00 0.93 0.2
64 INT167940 Regulation of Stat5b 1 0.43 0 0.19
65 INT145257 Positive_regulation of Acly 1 0.03 1.39 0.18
66 INT184024 Binding of Stat5a 1 0.25 0.11 0.17
67 INT184055 Positive_regulation of Binding of Stat5a 1 0.33 0.12 0.17
68 INT350667 Positive_regulation of Transcription of Stat5a 1 0.29 0.47 0.16
69 INT350637 Transcription of Stat5a 1 0.40 0.46 0.16
70 INT75314 Regulation of Gene_expression of Ghr 3 0.26 0.42 0.15
71 INT318985 Positive_regulation of Positive_regulation of ACLY 1 0.08 1.77 0.15
72 INT244569 Phosphorylation of CS 1 0.31 2.96 0.15
73 INT220367 Regulation of Positive_regulation of Ghr 1 0.44 0.45 0.14
74 INT22020 Regulation of Positive_regulation of GHR 1 0.39 1.03 0.14
75 INT259037 Negative_regulation of Binding of ACLY 1 0.07 1.54 0.13
76 INT281872 Positive_regulation of Positive_regulation of Aco1 1 0.20 1.3 0.12
77 INT268793 Protein_catabolism of Ghr 1 0.69 0.54 0.12
78 INT244487 Regulation of Positive_regulation of CS 1 0.10 0.18 0.12
79 INT220368 Negative_regulation of Positive_regulation of Stat5a 1 0.34 0.46 0.11
80 INT131139 Binding of ACO1 3 0.27 1.81 0.1
81 INT95756 Gene_expression of ACO1 3 0.27 2.49 0.1
82 INT245586 Phosphorylation of Ghr 1 0.44 0.35 0.1
83 INT244553 Positive_regulation of Gene_expression of CS 6 0.22 3.07 0.09
84 INT173756 Positive_regulation of Transcription of Ghr 3 0.36 0.83 0.09
85 INT268791 Positive_regulation of Protein_catabolism of Ghr 1 0.39 0.29 0.09
86 INT131140 Negative_regulation of Negative_regulation of ACO1 1 0.37 0.58 0.09
87 INT336476 Positive_regulation of Binding of CS 1 0.09 0 0.09
88 INT259039 Positive_regulation of Binding of ACLY 1 0.09 1.85 0.09
89 INT329390 Negative_regulation of Gene_expression of Acly 1 0.10 0.83 0.09
90 INT259030 Negative_regulation of Gene_expression of ACLY 1 0.07 1.95 0.08
91 INT344278 Positive_regulation of Localization of ACLY 1 0.08 1.16 0.08
92 INT350646 Negative_regulation of Positive_regulation of Stat5a 1 0.25 0.23 0.08
93 INT313905 Localization of Stat5a 1 0.21 0.33 0.08
94 INT200180 Negative_regulation of Localization of Ghr 3 0.35 0.89 0.07
95 INT205533 Localization of CS 4 0.28 0.69 0.06
96 INT329391 Positive_regulation of Gene_expression of Acly 1 0.12 0.68 0.06
97 INT205887 Positive_regulation of Acly 1 0.31 0.37 0.06
98 INT239158 Negative_regulation of Positive_regulation of Aco1 2 0.17 1.26 0.05
99 INT281875 Negative_regulation of Gene_expression of Aco1 1 0.17 0.48 0.05
100 INT184168 Localization of GHR 1 0.08 0.34 0.05
101 INT244536 Negative_regulation of Gene_expression of CS 3 0.31 0.88 0.04
102 INT184061 Negative_regulation of Stat5a 2 0.29 1.85 0.04
103 INT204165 Regulation of Cs 2 0.09 1.35 0.04
104 INT281877 Regulation of Localization of Aco1 1 0.18 1.36 0.04
105 INT281871 Positive_regulation of Localization of Aco1 1 0.20 1.37 0.04
106 INT356345 Negative_regulation of Negative_regulation of Ghr 1 0.35 0.24 0.04
107 INT244518 Positive_regulation of Localization of CS 2 0.19 0.37 0.03
108 INT230012 Protein_catabolism of ACLY 1 0.37 0.27 0.03
109 INT173796 Gene_expression of Stat5a 5 0.56 1.41 0
110 INT181272 Positive_regulation of Gene_expression of ACLY 3 0.44 1.29 0
111 INT200803 Phosphorylation of Stat5a 2 0.59 1.23 0
112 INT192069 Localization of Acly 1 0.02 0.84 0
113 INT244530 Regulation of Binding of CS 1 0.17 0.06 0
114 INT319565 Positive_regulation of Gene_expression of GHR 1 0.25 0.4 0
115 INT200800 Positive_regulation of Phosphorylation of Stat5a 1 0.36 0.24 0
116 INT173755 Binding of Ghr 1 0.14 0 0
117 INT181205 Negative_regulation of Binding of GHR 1 0.07 0.2 0
118 INT317762 Localization of Acly 1 0.40 0.12 0
119 INT315623 Positive_regulation of Localization of ACO1 1 0.20 0.79 0
120 INT317760 Binding of Acly 1 0.19 0.08 0
121 INT75317 Regulation of Gene_expression of Ghr 1 0.03 0.26 0
122 INT315588 Regulation of ACO1 1 0.18 0.57 0
123 INT236412 Positive_regulation of Transcription of ACLY 1 0.44 0.4 0
124 INT329392 Negative_regulation of Acly 1 0.10 0.47 0
125 INT323587 Transcription of Aco1 1 0.03 0.1 0
126 INT236411 Transcription of ACLY 1 0.60 0.4 0
127 INT344633 Negative_regulation of Cs 1 0.42 0.82 0
128 INT200799 Positive_regulation of Gene_expression of Stat5a 1 0.36 0.37 0
129 INT244565 Negative_regulation of Phosphorylation of CS 1 0.16 0.24 0
130 INT252749 Regulation of Gene_expression of ACO1 1 0.02 0.9 0
131 INT198781 Regulation of Gene_expression of ACLY 1 0.39 0 0
132 INT192070 Positive_regulation of Localization of Acly 1 0.02 0.84 0
133 INT315574 Localization of ACO1 1 0.30 0.79 0
134 INT315616 Positive_regulation of Gene_expression of ACO1 1 0.20 0.79 0
135 INT353174 Gene_expression of Stat5b 1 0.48 0 0
136 INT315572 Positive_regulation of ACO1 1 0.20 0.94 0
137 INT323585 Regulation of Transcription of Aco1 1 0.02 0.1 0
138 INT200790 Positive_regulation of Positive_regulation of Stat5a 1 0.36 0.24 0
139 INT244515 Regulation of Gene_expression of CS 1 0.20 1.26 0
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