GO:0006103

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Name 2-oxoglutarate metabolic process
Categary Process
Go Slim No
Go Link GO:0006103
Unique Molecular Interactions 98
Total Molecular Interactions 120
Total Single Events 1350
Pain Genes Associated 16

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for 2-oxoglutarate metabolic process. They are ordered first by their pain relevance and then by number of times they were reported for 2-oxoglutarate metabolic process. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT69823 Binding of GHR and RYBP 1 0.01 0 3.23
2 INT288731 Binding of Got1 and Gpt 1 0.23 1.25 1.61
3 INT69824 Negative_regulation of Binding of GHR and RYBP 1 0.01 0 1.14
4 INT45279 Binding of CSF2 and GHR 1 0.05 0.07 0.93
5 INT160412 Tat Positive_regulation of Transcription of Nos2 1 0.37 0.98 0.86
6 INT160413 Tat Positive_regulation of Gene_expression of Cd40lg 1 0.50 0.98 0.86
7 INT167944 Binding of Oprm1 and Stat5a 1 0.00 0 0.85
8 INT73775 Binding of GH1 and GHR 4 0.35 0.68 0.8
9 INT160411 Tat Positive_regulation of Il6 1 0.17 0.89 0.8
10 INT34241 Dlst Positive_regulation of Positive_regulation of LH 1 0.28 0 0.77
11 INT73776 Regulation of Binding of GH1 and GHR 2 0.26 0.16 0.75
12 INT19577 Gabrg1 Negative_regulation of Got1 1 0.04 0.16 0.74
13 INT160414 Hivan1 Positive_regulation of Tat 1 0.15 0.84 0.66
14 INT115764 Binding of Rbm39 and Tat 1 0.00 0 0.66
15 INT78663 Dlst Regulation of Nos1 1 0.19 0.91 0.65
16 INT126614 Ppyr1 Negative_regulation of Phosphorylation of Stat5a 1 0.27 0.1 0.64
17 INT137099 Dlst Regulation of Sec22b 1 0.05 0 0.64
18 INT137100 Dlst Regulation of Htr1a 1 0.18 0 0.64
19 INT152766 TAT Positive_regulation of Positive_regulation of MYLK 1 0.44 0.67 0.61
20 INT126615 Binding of Oprd1 and Stat5a 1 0.28 0.07 0.61
21 INT152765 TAT Regulation of Positive_regulation of MYLK 1 0.40 0.66 0.6
22 INT34239 Dlst Regulation of Positive_regulation of LH 1 0.27 0 0.57
23 INT34242 Dlst Regulation of Localization of LH 1 0.43 0 0.55
24 INT184130 Epo Positive_regulation of Stat5a 1 0.31 0.26 0.52
25 INT184096 Il7 Positive_regulation of Stat5a 1 0.07 0.26 0.51
26 INT184132 Il2 Positive_regulation of Stat5a 1 0.09 0.26 0.51
27 INT288729 Positive_regulation of Binding of Got1 and Gpt 1 0.25 0.61 0.49
28 INT90252 Binding of PPBP and TAT 1 0.39 5.55 0.48
29 INT90262 Binding of TAT and Pf4 1 0.03 5.64 0.48
30 INT17059 Binding of DLD and Oxt 1 0.03 0.22 0.41
31 INT167946 Binding of SRC and Stat5b 1 0.28 0 0.38
32 INT308889 Binding of Idh1 and Adp 1 0.02 0 0.36
33 INT308890 Binding of Idh1 and P2ry13 1 0.06 0 0.35
34 INT96102 Binding of TAT and Selp 1 0.04 0.7 0.3
35 INT96082 Binding of SELP and TAT 1 0.40 0.69 0.3
36 INT266800 Dlst Positive_regulation of Localization of VEGFA 1 0.02 0.88 0.29
37 INT96099 Binding of TAT and F2 1 0.01 0.68 0.29
38 INT5933 Dlst Regulation of Oprm1 1 0.09 0.51 0.28
39 INT39299 Binding of Prl and Dlst 1 0.20 0 0.27
40 INT91449 Gpt Positive_regulation of Got1 1 0.01 3.26 0.26
41 INT266803 Dlst Positive_regulation of VEGFA 1 0.01 0.96 0.25
42 INT266802 Dlst Positive_regulation of CCL5 1 0.00 0.95 0.25
43 INT266801 Dlst Positive_regulation of IL8 1 0.00 0.95 0.25
44 INT308815 Got1 Positive_regulation of Ldha 1 0.09 0.71 0.24
45 INT308818 Got1 Positive_regulation of Tnf 1 0.08 0.71 0.24
46 INT245590 Ghr Positive_regulation of Gene_expression of Igf1 1 0.34 0.61 0.23
47 INT288732 Got1 Positive_regulation of Gene_expression of Gpt 1 0.31 0.52 0.23
48 INT20202 Binding of TAT and Fgf12 1 0.01 1.5 0.17
49 INT20203 Positive_regulation of Binding of TAT and Fgf12 1 0.01 1.51 0.17
50 INT78662 Dlst Positive_regulation of Gene_expression of Nos1 1 0.20 0.17 0.14
51 INT184129 Socs2 Negative_regulation of Stat5a 1 0.22 0.05 0.13
52 INT11632 Binding of SERPINE1 and TAT 1 0.11 0.78 0.13
53 INT3751 Binding of GOT1 and PIK3C2A 1 0.08 0.68 0.12
54 INT3752 Binding of GOT1 and LDHA 1 0.11 0.68 0.12
55 INT35374 Dlst Positive_regulation of Tk1 1 0.02 0.26 0.11
56 INT35373 Negative_regulation of Dlst Positive_regulation of Tk1 1 0.02 0.27 0.11
57 INT156749 Gpt Positive_regulation of Gene_expression of Gpt2 1 0.50 0.22 0.1
58 INT156751 Gpt2 Positive_regulation of Gpt 1 0.12 0.21 0.1
59 INT184089 Gh Positive_regulation of Stat5b 1 0.13 1.3 0.1
60 INT197914 Dlst Positive_regulation of Positive_regulation of S100g 1 0.06 0 0.1
61 INT73585 TAT Positive_regulation of Mb 1 0.15 0.64 0.09
62 INT76965 Mpo Negative_regulation of DLD 1 0.26 0.91 0.07
63 INT310321 DLD Negative_regulation of COQ10A 1 0.01 0.06 0.05
64 INT268798 Binding of Gh and Ghr 1 0.26 1.18 0.04
65 INT24466 Binding of Dlst and Foxp4 1 0.00 0 0.03
66 INT265881 GHRH Positive_regulation of GHR 1 0.05 0.05 0.03
67 INT218964 Dlst Regulation of AR 1 0.01 0 0.03
68 INT197903 Dlst Positive_regulation of S100g 1 0.04 0 0
69 INT353192 Stat5a Positive_regulation of Plxna3 1 0.01 0 0
70 INT218963 Dlst Negative_regulation of AR 1 0.00 0.1 0
71 INT191699 Binding of TAT and TAR 1 0.03 0.75 0
72 INT218952 Dlst Negative_regulation of Igf1 1 0.03 0.1 0
73 INT191700 Positive_regulation of Binding of TAT and TAR 1 0.04 0.76 0
74 INT191698 Binding of TAT and SORBS1 1 0.01 1.08 0
75 INT173769 Dlat Regulation of Ghr 1 0.04 0 0
76 INT276300 TAT Regulation of Gene_expression of VEGFA 1 0.14 1.58 0
77 INT218976 Dlst Positive_regulation of Gene_expression of PCNA 1 0.05 0.06 0
78 INT218954 Dlst Regulation of Gene_expression of Igf1 1 0.03 0 0
79 INT197907 Dlst Regulation of S100a6 1 0.10 0 0
80 INT197911 Dlst Positive_regulation of Gene_expression of Esr1 1 0.03 0.34 0
81 INT197908 Dlst Positive_regulation of Esr1 1 0.03 0.34 0
82 INT218951 Negative_regulation of Dlst Negative_regulation of Igf1 1 0.03 0.1 0
83 INT197899 Dlst Positive_regulation of Ldha 1 0.04 0.34 0
84 INT216465 Gh Positive_regulation of Ghr 1 0.26 0.23 0
85 INT197912 Dlst Positive_regulation of Gene_expression of Pgr 1 0.01 0.34 0
86 INT247003 Binding of Ghr and Gh1 1 0.00 0 0
87 INT336179 Binding of CACNA1F and DLST 1 0.01 1.6 0
88 INT197904 Dlst Positive_regulation of Positive_regulation of S100a6 1 0.09 0 0
89 INT197898 Dlst Regulation of Gene_expression of S100a6 1 0.14 0 0
90 INT176919 Binding of DLD and Bpifa2 1 0.00 0.08 0
91 INT353190 Stat5a Positive_regulation of Cyp2c11 1 0.31 0 0
92 INT218962 Dlst Regulation of Gene_expression of AR 1 0.01 0 0
93 INT176920 DLD Positive_regulation of Binding of Bpifa2 1 0.00 0.08 0
94 INT218975 Dlst Negative_regulation of Gnrh1 1 0.16 0.16 0
95 INT92728 Dlst Positive_regulation of Pomc 1 0.19 0 0
96 INT197906 Dlst Positive_regulation of Gene_expression of Ldha 1 0.03 0.31 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for 2-oxoglutarate metabolic process. They are ordered first by their pain relevance and then by number of times they were reported in 2-oxoglutarate metabolic process. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT2604 Positive_regulation of Got1 223 0.70 154.78 49.51
2 INT4420 Positive_regulation of GOT1 103 0.64 88.4 18.38
3 INT2480 Negative_regulation of Got1 43 0.51 14.47 16.09
4 INT3851 Gene_expression of Got1 58 0.65 29.15 10.52
5 INT11150 Positive_regulation of Dlst 31 0.51 9.01 6.63
6 INT4208 Regulation of Got1 23 0.44 6.72 6.62
7 INT9895 Binding of GHR 18 0.36 4.8 5.65
8 INT8866 Positive_regulation of TAT 30 0.67 18.06 5.57
9 INT17056 Gene_expression of DLD 37 0.57 13.15 5.47
10 INT27415 Negative_regulation of Positive_regulation of Got1 15 0.51 10.99 5.14
11 INT126608 Binding of Stat5a 7 0.48 0.46 4.38
12 INT95512 Transcription of Ghr 24 0.69 3.1 4.12
13 INT14717 Gene_expression of TAT 20 0.75 10.67 3.66
14 INT10594 Gene_expression of Dlst 33 0.57 6 3.38
15 INT3919 Localization of Got1 10 0.71 2.95 3.28
16 INT31340 Positive_regulation of Gene_expression of Got1 20 0.46 10.5 3.17
17 INT7909 Positive_regulation of Positive_regulation of Got1 8 0.49 6.44 3.06
18 INT12796 Binding of DLD 20 0.36 6.71 3.02
19 INT59905 Gene_expression of Ghr 29 0.63 9.25 2.97
20 INT45971 Negative_regulation of GOT1 9 0.51 6.2 2.84
21 INT7142 Positive_regulation of DLD 22 0.60 7.69 2.76
22 INT4419 Gene_expression of GOT1 20 0.65 22.53 2.53
23 INT126610 Phosphorylation of Stat5a 5 0.82 0.8 2.52
24 INT53447 Negative_regulation of DLD 17 0.54 12.9 2.48
25 INT56918 Negative_regulation of TAT 11 0.57 5.92 2.44
26 INT22019 Regulation of GHR 9 0.62 2.56 2.39
27 INT16286 Positive_regulation of GHR 8 0.60 4.04 2.31
28 INT67352 Transcription of Ghr 8 0.61 1.55 2.3
29 INT95510 Regulation of Ghr 1 0.45 0.21 2.07
30 INT4643 Negative_regulation of GHR 10 0.45 3.01 2
31 INT24464 Binding of Dlst 8 0.29 0.52 1.99
32 INT35370 Negative_regulation of Dlst 6 0.32 2.58 1.9
33 INT126609 Positive_regulation of Phosphorylation of Stat5a 1 0.69 0.26 1.79
34 INT17452 Regulation of Dlst 14 0.46 1.5 1.68
35 INT75316 Gene_expression of Ghr 6 0.78 1.24 1.68
36 INT53451 Regulation of TAT 6 0.44 3.07 1.61
37 INT28300 Gene_expression of GHR 10 0.78 4.29 1.5
38 INT17453 Localization of Dlst 20 0.59 4.54 1.46
39 INT67348 Negative_regulation of Ghr 8 0.40 2.84 1.43
40 INT75315 Regulation of Ghr 4 0.22 1.5 1.34
41 INT126605 Negative_regulation of Binding of Stat5a 1 0.58 0.15 1.27
42 INT36330 Positive_regulation of Positive_regulation of GOT1 4 0.32 4.42 1.26
43 INT32120 Binding of Got1 3 0.29 1.98 1.16
44 INT95511 Negative_regulation of Transcription of Ghr 1 0.43 0 1.15
45 INT61512 Regulation of Binding of GHR 2 0.05 0.89 1.1
46 INT3529 Regulation of GOT1 6 0.52 2.4 1.01
47 INT95514 Negative_regulation of Ghr 3 0.36 1.3 0.99
48 INT61613 Regulation of DLD 6 0.34 2.96 0.92
49 INT95507 Negative_regulation of Gene_expression of Ghr 3 0.33 0.49 0.91
50 INT184015 Positive_regulation of Stat5a 9 0.46 3.32 0.86
51 INT216456 Positive_regulation of Ghr 6 0.41 4.96 0.85
52 INT96678 Binding of TAT 3 0.47 6.75 0.85
53 INT167938 Positive_regulation of Phosphorylation of Stat5b 1 0.33 0 0.85
54 INT167942 Binding of Stat5b 1 0.26 0 0.82
55 INT12190 Negative_regulation of Localization of Got1 2 0.21 0.98 0.8
56 INT48909 Localization of DLD 9 0.63 3.37 0.75
57 INT245584 Positive_regulation of Gene_expression of Ghr 5 0.41 3.46 0.75
58 INT12099 Localization of GOT1 2 0.35 2.54 0.72
59 INT132497 Negative_regulation of Negative_regulation of Got1 1 0.20 0 0.71
60 INT73783 Regulation of Gene_expression of GHR 1 0.45 0 0.7
61 INT34235 Positive_regulation of Positive_regulation of Dlst 2 0.26 0.25 0.65
62 INT126606 Negative_regulation of Stat5a 1 0.43 0.08 0.64
63 INT107119 Positive_regulation of Idh1 1 0.36 0.42 0.63
64 INT159942 Positive_regulation of Stat5a 3 0.41 0.95 0.61
65 INT126612 Negative_regulation of Phosphorylation of Stat5a 1 0.42 0.1 0.61
66 INT95506 Negative_regulation of Transcription of Ghr 1 0.15 0 0.6
67 INT167680 Localization of Tat 1 0.73 0.84 0.58
68 INT95508 Negative_regulation of Gene_expression of Ghr 1 0.59 0 0.56
69 INT51485 Localization of TAT 3 0.78 2.18 0.55
70 INT23239 Positive_regulation of Regulation of Got1 2 0.10 0.27 0.54
71 INT11867 Positive_regulation of Positive_regulation of TAT 2 0.49 2.02 0.54
72 INT55594 Negative_regulation of Positive_regulation of DLD 1 0.02 0.62 0.53
73 INT78661 Positive_regulation of Gene_expression of Dlst 4 0.24 1.23 0.51
74 INT163114 Positive_regulation of Gene_expression of GOT1 7 0.24 8.93 0.5
75 INT156744 Gene_expression of Gpt2 1 0.72 5.1 0.49
76 INT197071 Regulation of Localization of Dlst 1 0.46 1.06 0.47
77 INT141799 Transcription of Got1 2 0.35 1.41 0.43
78 INT47387 Negative_regulation of Positive_regulation of GOT1 2 0.26 1.04 0.43
79 INT141796 Negative_regulation of Transcription of Got1 1 0.22 0.43 0.43
80 INT167941 Phosphorylation of Stat5b 1 0.58 0 0.42
81 INT173752 Positive_regulation of Ghr 3 0.57 2.21 0.41
82 INT82331 Positive_regulation of Positive_regulation of GHR 1 0.00 0.06 0.4
83 INT48272 Negative_regulation of Protein_catabolism of Got1 1 0.15 0 0.39
84 INT231341 Negative_regulation of Gene_expression of Got1 2 0.12 1.21 0.38
85 INT48271 Protein_catabolism of Got1 1 0.31 0 0.38
86 INT308876 Binding of Idh1 2 0.23 0.77 0.35
87 INT28299 Negative_regulation of Gene_expression of GHR 1 0.03 0.1 0.35
88 INT55801 Regulation of Positive_regulation of Got1 3 0.08 2.08 0.33
89 INT284123 Binding of DLST 2 0.32 2.3 0.29
90 INT67350 Binding of Ghr 9 0.43 1.83 0.28
91 INT32119 Positive_regulation of Binding of Got1 1 0.13 0.89 0.28
92 INT67349 Localization of Ghr 6 0.66 2.53 0.23
93 INT67351 Positive_regulation of Localization of Ghr 2 0.44 0.78 0.23
94 INT310950 Gene_expression of DLST 3 0.58 3.03 0.22
95 INT55802 Regulation of Gene_expression of Got1 2 0.14 1.23 0.22
96 INT35369 Negative_regulation of Gene_expression of Dlst 2 0.05 0.7 0.21
97 INT334589 Positive_regulation of Negative_regulation of Got1 1 0.08 1.15 0.21
98 INT55871 Binding of GOT1 1 0.04 2.22 0.19
99 INT167940 Regulation of Stat5b 1 0.43 0 0.19
100 INT128120 Transcription of DLD 1 0.67 0 0.18
101 INT184024 Binding of Stat5a 1 0.25 0.11 0.17
102 INT184055 Positive_regulation of Binding of Stat5a 1 0.33 0.12 0.17
103 INT43708 Negative_regulation of Binding of DLD 1 0.35 0.17 0.17
104 INT147951 Gene_expression of Idh1 1 0.11 0.34 0.16
105 INT350667 Positive_regulation of Transcription of Stat5a 1 0.29 0.47 0.16
106 INT350637 Transcription of Stat5a 1 0.40 0.46 0.16
107 INT75314 Regulation of Gene_expression of Ghr 3 0.26 0.42 0.15
108 INT159088 Gene_expression of Tat 1 0.75 1.43 0.15
109 INT220367 Regulation of Positive_regulation of Ghr 1 0.44 0.45 0.14
110 INT22020 Regulation of Positive_regulation of GHR 1 0.39 1.03 0.14
111 INT197867 Negative_regulation of Binding of Dlst 1 0.10 0 0.14
112 INT90231 Regulation of Idh1 1 0.02 0.1 0.13
113 INT90230 Transcription of Idh1 1 0.03 0.1 0.13
114 INT154678 Positive_regulation of Gene_expression of TAT 2 0.49 1.7 0.12
115 INT342900 Negative_regulation of Regulation of GOT1 1 0.04 0.42 0.12
116 INT197069 Positive_regulation of Localization of Dlst 1 0.51 0 0.12
117 INT268793 Protein_catabolism of Ghr 1 0.69 0.54 0.12
118 INT83129 Protein_catabolism of DLD 1 0.02 0 0.12
119 INT197070 Negative_regulation of Localization of Dlst 1 0.32 0 0.12
120 INT220368 Negative_regulation of Positive_regulation of Stat5a 1 0.34 0.46 0.11
121 INT245586 Phosphorylation of Ghr 1 0.44 0.35 0.1
122 INT156747 Positive_regulation of Gpt2 1 0.43 0.21 0.1
123 INT173756 Positive_regulation of Transcription of Ghr 3 0.36 0.83 0.09
124 INT268791 Positive_regulation of Protein_catabolism of Ghr 1 0.39 0.29 0.09
125 INT156746 Negative_regulation of Gene_expression of Gpt2 1 0.40 0.59 0.09
126 INT137756 Regulation of Negative_regulation of DLD 1 0.02 0.09 0.09
127 INT156745 Localization of Gpt2 1 0.75 0.44 0.09
128 INT350646 Negative_regulation of Positive_regulation of Stat5a 1 0.25 0.23 0.08
129 INT313905 Localization of Stat5a 1 0.21 0.33 0.08
130 INT200180 Negative_regulation of Localization of Ghr 3 0.35 0.89 0.07
131 INT262774 Negative_regulation of DLST 1 0.23 0.43 0.07
132 INT197068 Regulation of Regulation of Dlst 1 0.33 0.24 0.07
133 INT310951 Positive_regulation of DLST 2 0.43 2.71 0.06
134 INT244341 Regulation of Binding of DLD 1 0.30 0.19 0.06
135 INT184168 Localization of GHR 1 0.08 0.34 0.05
136 INT184061 Negative_regulation of Stat5a 2 0.29 1.85 0.04
137 INT356345 Negative_regulation of Negative_regulation of Ghr 1 0.35 0.24 0.04
138 INT197485 Regulation of Positive_regulation of GOT1 1 0.01 0.44 0.04
139 INT197486 Positive_regulation of Regulation of GOT1 1 0.01 0.44 0.04
140 INT191701 Regulation of Binding of TAT 1 0.26 0.43 0.04
141 INT218946 Regulation of Protein_catabolism of Dlst 1 0.05 0.17 0.03
142 INT218950 Protein_catabolism of Dlst 1 0.11 0.17 0.03
143 INT173796 Gene_expression of Stat5a 5 0.56 1.41 0
144 INT200803 Phosphorylation of Stat5a 2 0.59 1.23 0
145 INT319565 Positive_regulation of Gene_expression of GHR 1 0.25 0.4 0
146 INT200800 Positive_regulation of Phosphorylation of Stat5a 1 0.36 0.24 0
147 INT273143 Negative_regulation of Tat 1 0.01 2.3 0
148 INT173755 Binding of Ghr 1 0.14 0 0
149 INT181205 Negative_regulation of Binding of GHR 1 0.07 0.2 0
150 INT217416 Positive_regulation of Positive_regulation of DLD 1 0.42 0.19 0
151 INT75317 Regulation of Gene_expression of Ghr 1 0.03 0.26 0
152 INT310952 Localization of DLST 1 0.64 0.82 0
153 INT221520 Negative_regulation of Gene_expression of DLD 1 0.04 0.27 0
154 INT218944 Regulation of Gene_expression of Dlst 1 0.05 0 0
155 INT336196 Negative_regulation of Gene_expression of DLST 1 0.07 1.03 0
156 INT200799 Positive_regulation of Gene_expression of Stat5a 1 0.36 0.37 0
157 INT353174 Gene_expression of Stat5b 1 0.48 0 0
158 INT200790 Positive_regulation of Positive_regulation of Stat5a 1 0.36 0.24 0
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