GO:0006112

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Name energy reserve metabolic process
Categary Process
Go Slim No
Go Link GO:0006112
Unique Molecular Interactions 842
Total Molecular Interactions 1114
Total Single Events 11874
Pain Genes Associated 51

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for energy reserve metabolic process. They are ordered first by their pain relevance and then by number of times they were reported for energy reserve metabolic process. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT83169 Binding of Cck and Lep 7 0.42 1.58 2.78
2 INT278948 LEP Positive_regulation of Gene_expression of PTGER2 1 0.09 4.04 2.69
3 INT122660 Binding of CACNA1A and DNAH8 2 0.28 2.68 2.08
4 INT278937 LEP Positive_regulation of Gene_expression of IL6 1 0.32 3.42 1.97
5 INT83170 Lep Regulation of Cck 5 0.43 0.68 1.96
6 INT183781 Binding of IL6 and INS 6 0.22 8.97 1.87
7 INT134363 Prkcg Regulation of ADCY2 1 0.00 0.14 1.7
8 INT135516 PRKCA Negative_regulation of Phosphorylation of OPRM1 1 0.12 0 1.62
9 INT118515 Positive_regulation of PRKCA Positive_regulation of Phosphorylation of TRPV1 1 0.27 0.56 1.58
10 INT89011 Lep Positive_regulation of Insr 1 0.19 2.41 1.57
11 INT41100 Mdk Positive_regulation of Localization of INS 1 0.01 0 1.55
12 INT166676 Binding of PRKCA and UGT1A6 1 0.30 0 1.5
13 INT108727 Binding of ATP1A2 and CACNA1A 2 0.34 1.97 1.37
14 INT122659 Binding of CACNA1A and SAR1B 1 0.06 1.38 1.35
15 INT115985 Cpe Positive_regulation of Binding of Gnas 1 0.00 0.17 1.28
16 INT131462 NGF Regulation of Localization of INS 1 0.40 0.97 1.2
17 INT65203 OPRL1 Negative_regulation of ADCY1 1 0.19 0 1.19
18 INT49955 OPRM1 Positive_regulation of ADCY1 1 0.21 0.31 1.19
19 INT98908 Binding of NTRK1 and PKLR 1 0.41 1.95 1.18
20 INT98906 Positive_regulation of Binding of NTRK1 and PKLR 1 0.56 1.95 1.18
21 INT65204 PNOC Negative_regulation of ADCY1 1 0.07 0 1.14
22 INT130627 Gnas Regulation of Prkaca 1 0.00 0 1.13
23 INT323175 PRKCA Positive_regulation of Akt1 1 0.02 0 1.1
24 INT81788 Binding of AGRP and MC4R 4 0.51 0 1.09
25 INT331108 Mc1r Positive_regulation of Mc4r 1 0.44 1.05 1.06
26 INT30905 SST Negative_regulation of Localization of GCG 2 0.12 1.56 1.04
27 INT117311 HP Positive_regulation of Lep 1 0.00 1.78 1.01
28 INT278962 LEP Positive_regulation of CPOX 1 0.05 1.33 1
29 INT53052 ANTXRL Negative_regulation of Negative_regulation of ADCY1 1 0.01 0.66 0.99
30 INT69506 CA2 Positive_regulation of PRKCA 1 0.50 0.42 0.98
31 INT40424 CCK Regulation of Localization of INS 1 0.02 0 0.97
32 INT75283 SST Negative_regulation of Localization of INS 2 0.47 1.45 0.96
33 INT278940 LEP Positive_regulation of Gene_expression of IL8 1 0.34 1.68 0.96
34 INT108729 Binding of CACNA1A and Cacna1a 3 0.13 1.21 0.95
35 INT62109 SLC25A4 Negative_regulation of Localization of Gh 1 0.06 0 0.94
36 INT72213 Positive_regulation of PRKCA Regulation of Gene_expression of METTL3 1 0.05 0.17 0.93
37 INT52114 Oprd1 Regulation of ADCY1 2 0.05 0.46 0.9
38 INT62111 SLC25A4 Negative_regulation of Regulation of Ghrh 1 0.41 0 0.9
39 INT109103 MMP2 Positive_regulation of INS 1 0.33 1.07 0.89
40 INT52390 OPRD1 Regulation of ADCY1 1 0.09 0.13 0.86
41 INT114324 RAF1 Positive_regulation of Phosphorylation of ADCY6 1 0.02 0.05 0.85
42 INT114323 Binding of ADCY6 and RAF1 1 0.02 0.05 0.85
43 INT80877 Negative_regulation of PCDHB17 Negative_regulation of ADCY1 1 0.01 0.08 0.84
44 INT80878 PCDHB17 Negative_regulation of ADCY1 1 0.01 0.08 0.84
45 INT189671 DAG1 Positive_regulation of PRKCA 3 0.12 0.71 0.82
46 INT131463 NTRK1 Regulation of Localization of INS 1 0.41 0.63 0.8
47 INT181616 INS Positive_regulation of IRS1 1 0.01 1 0.79
48 INT56459 ADRA2C Positive_regulation of Localization of AHSP 1 0.23 0 0.78
49 INT130948 Amt Regulation of Gene_expression of LEP 1 0.00 1.04 0.78
50 INT130949 Amt Regulation of LEP 1 0.00 1.04 0.77
51 INT316544 BCL2L11 Regulation of INS 1 0.00 1.36 0.77
52 INT65593 CALCA Negative_regulation of Positive_regulation of ADCY1 1 0.23 0.07 0.76
53 INT166674 YY1 Regulation of Binding of PRKCA 1 0.38 0 0.75
54 INT278958 LEP Positive_regulation of IL1B 1 0.33 1.91 0.74
55 INT75937 MLXIPL Regulation of Csf2 1 0.01 0.68 0.74
56 INT41165 Gtf3a Regulation of INS 1 0.00 0.15 0.74
57 INT214163 Binding of Lep and Nts 1 0.04 0.21 0.74
58 INT31642 POMC Regulation of GCG 1 0.41 0.62 0.73
59 INT41164 Binding of INS and SST 1 0.07 0.14 0.73
60 INT31643 POMC Regulation of INS 1 0.59 0.62 0.73
61 INT16048 MAX Positive_regulation of SLC25A4 1 0.50 0 0.71
62 INT123869 Binding of GNAS and OPRK1 1 0.00 0.37 0.7
63 INT214410 Binding of ATP1A4 and CACNA1A 1 0.26 0.95 0.7
64 INT89009 Lep Positive_regulation of Cck 2 0.67 0.43 0.69
65 INT278956 LEP Regulation of Gene_expression of IL8 1 0.30 1.11 0.69
66 INT278968 LEP Regulation of Gene_expression of IL6 1 0.29 1.11 0.69
67 INT278951 LEP Regulation of Gene_expression of PTGER2 1 0.07 1.11 0.69
68 INT166673 PRKCA Negative_regulation of UGT1A6 1 0.36 0 0.69
69 INT74599 YY1 Negative_regulation of ADCY1 2 0.36 0.31 0.67
70 INT299989 PRKCA Positive_regulation of Gene_expression of IL8 1 0.04 0.45 0.67
71 INT314560 RYBP Positive_regulation of Gene_expression of MYC 1 0.02 0.06 0.67
72 INT278965 LEP Positive_regulation of Gene_expression of NOS2 2 0.29 2.12 0.66
73 INT189704 PRKCA Regulation of CHKB 1 0.13 0.18 0.66
74 INT81832 Binding of ADRA2C and CRYGS 1 0.06 0 0.66
75 INT30902 GCG Positive_regulation of Localization of SST 1 0.11 0.05 0.62
76 INT337323 KNG1 Positive_regulation of PRKCA 1 0.15 0.17 0.62
77 INT323773 Binding of Il6 and Lep 1 0.29 3.54 0.6
78 INT242883 INS Negative_regulation of Gene_expression of TLR2 1 0.17 2.35 0.6
79 INT81606 Positive_regulation of PRKCA Positive_regulation of Phosphorylation of TACR1 1 0.29 0 0.6
80 INT29847 INS Regulation of Localization of AVP 1 0.23 0.24 0.59
81 INT120348 Negative_regulation of Binding of DES and MYC 1 0.06 0.18 0.58
82 INT291262 Positive_regulation of INS Positive_regulation of Mapk1 1 0.03 1.78 0.58
83 INT120350 Binding of DES and MYC 1 0.05 0.17 0.58
84 INT291258 INS Positive_regulation of Mapk1 1 0.04 1.77 0.58
85 INT103165 NGF Positive_regulation of Localization of INS 1 0.05 0 0.58
86 INT120347 Binding of KNG1 and MYC 1 0.21 0.17 0.58
87 INT81605 PRKCA Positive_regulation of Phosphorylation of TACR1 1 0.43 0 0.57
88 INT349083 Binding of Lep and Rtn1 1 0.09 1.68 0.57
89 INT323176 PRKCA Positive_regulation of Phosphorylation of Akt1 1 0.02 0 0.56
90 INT91339 Binding of Lep and Cck 1 0.28 0.34 0.56
91 INT323148 PRKCA Positive_regulation of RAF1 1 0.01 0 0.55
92 INT210830 OPRM1 Negative_regulation of ADCY1 1 0.00 0.06 0.55
93 INT113162 Lep Positive_regulation of Positive_regulation of Insrr 1 0.03 0 0.55
94 INT253834 Cck Regulation of Lep 1 0.19 0.23 0.55
95 INT108021 Binding of Pomc and Mc4r 1 0.00 0.97 0.55
96 INT323150 PRKCA Positive_regulation of Phosphorylation of RAF1 1 0.01 0 0.55
97 INT32908 Binding of ADCY1 and Drd2 1 0.00 0 0.54
98 INT204087 IL1B Positive_regulation of Gene_expression of LEP 1 0.09 2.6 0.54
99 INT64744 OR5D2P Negative_regulation of ADCY1 1 0.00 0 0.54
100 INT29252 Regulation of INS Positive_regulation of GH1 1 0.26 0.08 0.54
101 INT323146 PRKCA Positive_regulation of MAPK1 1 0.02 0 0.54
102 INT214160 Binding of Lep and Mc4r 1 0.29 1.31 0.53
103 INT214164 Binding of Mc4r and Pomc 1 0.39 1.31 0.53
104 INT214143 Binding of Lep and Pomc 1 0.27 1.2 0.53
105 INT29253 INS Positive_regulation of GH1 1 0.44 0.08 0.53
106 INT311767 INS Negative_regulation of Gene_expression of SLC1A3 1 0.52 0 0.52
107 INT108467 GCG Positive_regulation of Cck 1 0.02 0.16 0.51
108 INT89186 Agrp Negative_regulation of Mc4r 1 0.40 0 0.51
109 INT93265 Binding of ADCY1 and OPRL1 1 0.13 0.17 0.51
110 INT189688 PRKCA Regulation of Transcription of TERT 1 0.13 0.2 0.5
111 INT189696 PRKCA Negative_regulation of Negative_regulation of TEP1 1 0.02 0.15 0.5
112 INT130335 Binding of Mc4r and Nr3c2 1 0.06 1.87 0.5
113 INT189680 PRKCA Negative_regulation of TEP1 1 0.02 0.15 0.5
114 INT189675 Negative_regulation of PRKCA Negative_regulation of TEP1 1 0.02 0.15 0.5
115 INT25524 Oprd1 Regulation of Localization of GCG 1 0.01 0.52 0.48
116 INT162890 Negative_regulation of Binding of LEP and Tnf 1 0.03 0.49 0.48
117 INT162889 Binding of LEP and Tnf 1 0.03 0.49 0.48
118 INT34006 Binding of ITPR3 and YY1 1 0.22 0.33 0.48
119 INT261648 BDKRB1 Regulation of PRKCA 1 0.03 1.9 0.47
120 INT101001 GHRH Regulation of Localization of INS 1 0.28 0 0.47
121 INT89647 OPRM1 Regulation of ADCY1 1 0.09 0.09 0.47
122 INT153658 PRKCA Negative_regulation of GEM 1 0.01 0.22 0.46
123 INT153657 PRKCA Negative_regulation of MED23 1 0.01 0.22 0.46
124 INT132580 Binding of ADRA2C and Htr1a 1 0.41 0.27 0.45
125 INT132509 Binding of LEP and Cck 1 0.13 0.16 0.45
126 INT110475 EDN1 Regulation of PRKCA 1 0.05 0.07 0.45
127 INT258584 ADORA3 Negative_regulation of ADCY1 1 0.02 0 0.44
128 INT111275 BRI3P1 Positive_regulation of Negative_regulation of ADCY1 1 0.06 0 0.44
129 INT89649 INSRR Regulation of ADCY1 1 0.00 0.07 0.44
130 INT111274 C2 Positive_regulation of Negative_regulation of ADCY1 1 0.14 0 0.44
131 INT29254 Positive_regulation of ADRA2C Positive_regulation of Localization of GH1 1 0.13 0.06 0.44
132 INT73832 Pld1 Positive_regulation of ADCY1 1 0.00 0.16 0.44
133 INT337326 PIK3CD Positive_regulation of Localization of ITPR3 1 0.02 0 0.43
134 INT337324 PIK3CD Positive_regulation of Gene_expression of ITPR3 1 0.02 0 0.43
135 INT155752 Binding of CACNA1A and ATCAY 1 0.04 0.86 0.42
136 INT323880 Binding of BMI1 and LEP 1 0.02 3.97 0.41
137 INT68526 Binding of ADCY1 and DIO2 1 0.01 0.07 0.41
138 INT68527 Binding of ADCY1 and OPRD1 1 0.06 0.07 0.41
139 INT105170 OPRD1 Positive_regulation of Phosphorylation of ADCY1 1 0.08 0 0.41
140 INT189681 Negative_regulation of PRKCA Negative_regulation of Gene_expression of METTL3 1 0.00 0.16 0.41
141 INT240618 Binding of INS and ADIPOQ 3 0.17 2.54 0.4
142 INT11425 OR2A12 Positive_regulation of Negative_regulation of ADCY1 1 0.01 0 0.4
143 INT83171 Cck Regulation of Lep 1 0.30 0.09 0.4
144 INT285725 Binding of IGF1R and INS 1 0.27 0.07 0.4
145 INT105169 RAF1 Regulation of Positive_regulation of ADCY1 1 0.12 0 0.4
146 INT189689 CHKB Negative_regulation of Positive_regulation of PRKCA 1 0.11 0 0.4
147 INT124799 PRKCA Positive_regulation of Localization of ADCY6 1 0.19 0 0.4
148 INT97395 Lep Positive_regulation of Stat3 1 0.67 0.42 0.4
149 INT29052 Binding of INS and INSRR 1 0.02 0.23 0.4
150 INT29053 Regulation of Binding of INS and INSRR 1 0.01 0.24 0.4
151 INT78621 PRL Positive_regulation of Localization of INS 2 0.06 0.5 0.39
152 INT33713 Binding of ITPR3 and Trh 1 0.00 0.86 0.39
153 INT291256 INS Negative_regulation of Positive_regulation of Mdk 1 0.01 1.65 0.39
154 INT134167 Binding of ADRA2A and APLP1 1 0.09 0.64 0.39
155 INT124798 RAF1 Regulation of PRKCA 1 0.06 0 0.39
156 INT62110 SLC25A4 Negative_regulation of Regulation of Gh 1 0.06 0 0.39
157 INT143747 Binding of IL6 and LEP 2 0.04 4.05 0.38
158 INT43956 GCG Regulation of ALB 1 0.16 0.15 0.38
159 INT113040 IHH Regulation of Gene_expression of INS 1 0.12 0.37 0.37
160 INT278955 JAK3 Positive_regulation of Gene_expression of PRKCA 1 0.12 0.65 0.37
161 INT193034 PRKCA Regulation of Positive_regulation of CDK20 1 0.05 0.15 0.37
162 INT300488 Binding of CRP and LEP 1 0.46 2.03 0.37
163 INT214142 Agrp Positive_regulation of Mc4r 1 0.39 0.23 0.37
164 INT214145 Binding of Agrp and Mc4r 1 0.40 0.18 0.37
165 INT278938 MAPK14 Positive_regulation of Gene_expression of PRKCA 1 0.05 0.65 0.37
166 INT89386 INS Positive_regulation of Phosphorylation of AKT1 3 0.43 1.48 0.36
167 INT226785 Angpt2 Positive_regulation of Localization of Lep 1 0.01 1.65 0.36
168 INT278966 MAPK14 Positive_regulation of Gene_expression of LEP 1 0.16 0.62 0.36
169 INT278949 JAK3 Positive_regulation of Gene_expression of LEP 1 0.42 0.63 0.36
170 INT4382 RIPK2 Regulation of INS 1 0.12 0.58 0.36
171 INT13548 Binding of PDYN and TALDO1 1 0.40 0 0.35
172 INT323885 LEP Regulation of Gene_expression of NOS2 1 0.26 1.07 0.35
173 INT213484 Binding of Lep and Pik3c3 1 0.01 0 0.35
174 INT183786 IL6 Negative_regulation of INS 1 0.09 1.61 0.35
175 INT268110 PRKCA Positive_regulation of Phosphorylation of SNAP25 1 0.32 0.11 0.35
176 INT343857 Binding of ABCC8 and LY96 1 0.02 0.96 0.34
177 INT183784 INS Negative_regulation of Binding of TBK1 1 0.01 1.81 0.34
178 INT183783 INS Negative_regulation of TBK1 1 0.01 1.81 0.34
179 INT183793 INS Negative_regulation of Binding of Ros1 1 0.16 1.66 0.34
180 INT183785 INS Positive_regulation of Gene_expression of NFKBIB 1 0.03 1.83 0.34
181 INT183780 INS Negative_regulation of Gene_expression of CYBB 1 0.02 1.74 0.34
182 INT4381 RIPK2 Positive_regulation of Localization of INS 1 0.13 0.53 0.34
183 INT183782 INS Negative_regulation of Gene_expression of TBK1 1 0.01 1.81 0.34
184 INT89381 INS Positive_regulation of AKT1 6 0.43 3.06 0.33
185 INT239540 Binding of CXCR2 and MYC 1 0.15 0.09 0.33
186 INT88252 Binding of RAP1A and Krit1 1 0.36 2.25 0.33
187 INT207184 Binding of Adipoq and Lep 1 0.25 2.45 0.33
188 INT266383 Binding of Ager and S100b 1 0.01 3.48 0.33
189 INT171679 PPY Regulation of PRKCA 1 0.08 0.33 0.33
190 INT101551 Binding of CACNA1A and CACNA1F 1 0.07 1.51 0.33
191 INT323870 LEP Regulation of Gene_expression of MMP13 1 0.21 1.76 0.33
192 INT303993 Lep Positive_regulation of Gene_expression of IL2 1 0.15 0.24 0.33
193 INT171677 PRKCA Regulation of CISD1 1 0.00 0 0.33
194 INT190683 Binding of A2M and INS 4 0.11 4.97 0.32
195 INT241776 Binding of AVP and Positive_regulation of ADCY1 1 0.06 0.54 0.32
196 INT311228 DPP4 Negative_regulation of Localization of GLP1R 1 0.31 1.25 0.32
197 INT238895 Binding of CRP and INS 1 0.00 0.93 0.32
198 INT105873 Ins1 Negative_regulation of Positive_regulation of Lep 1 0.27 0.67 0.31
199 INT278942 LEP Regulation of IL6 1 0.29 0.61 0.31
200 INT278939 LEP Regulation of IL8 1 0.13 0.61 0.31

Single Events

The table below shows the top 100 pain related interactions that have been reported for energy reserve metabolic process. They are ordered first by their pain relevance and then by number of times they were reported in energy reserve metabolic process. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT812 Localization of INS 1026 0.81 515.6 145.31
2 INT3038 Gene_expression of INS 1583 0.78 1174.16 107.01
3 INT6490 Negative_regulation of ADCY1 145 0.58 26.25 70.96
4 INT1599 Positive_regulation of ADCY1 146 0.67 30.05 64.9
5 INT251 Regulation of INS 398 0.62 232.47 55.04
6 INT1199 Positive_regulation of INS 579 0.70 399.64 50.43
7 INT17881 Gene_expression of LEP 278 0.78 221.61 48.31
8 INT48718 Positive_regulation of PRKCA 109 0.69 36.16 46.49
9 INT1322 Positive_regulation of Localization of INS 293 0.70 120.86 45.98
10 INT3252 Negative_regulation of INS 428 0.59 271.65 39.52
11 INT3253 Negative_regulation of Localization of INS 205 0.59 130.39 36.61
12 INT2274 Regulation of Localization of INS 101 0.62 41.55 34.79
13 INT52712 Negative_regulation of PRKCA 64 0.57 23.11 28.43
14 INT101483 Gene_expression of Lep 159 0.78 104.77 25.12
15 INT17625 Localization of GCG 210 0.80 55.69 24.97
16 INT76123 Gene_expression of Lep 193 0.78 94.17 22.76
17 INT79805 Phosphorylation of PRKCA 57 0.81 23.33 20.41
18 INT82434 Positive_regulation of LEP 117 0.70 95.45 20.22
19 INT64442 Regulation of Mc4r 6 0.62 5.22 19.09
20 INT78024 Gene_expression of ACLY 73 0.75 59.15 18.54
21 INT12617 Regulation of ADCY1 41 0.61 7.38 15.94
22 INT62681 Negative_regulation of LEP 93 0.59 66.97 15.77
23 INT61172 Gene_expression of PRKCA 34 0.77 8.89 15.47
24 INT64447 Transcription of Mc4r 14 0.61 6.08 15.29
25 INT75908 Regulation of LEP 77 0.60 60.16 15.19
26 INT20420 Gene_expression of MYC 99 0.75 49.32 14.36
27 INT52714 Regulation of PRKCA 28 0.61 7.73 13.66
28 INT14572 Binding of INS 205 0.48 175.43 13.38
29 INT64445 Gene_expression of Mc4r 17 0.78 5.06 12.91
30 INT8210 Positive_regulation of Gene_expression of INS 188 0.68 146.57 12.83
31 INT73641 Regulation of Lep 45 0.62 26.2 12.59
32 INT11429 Gene_expression of ADCY1 26 0.74 5.89 11.93
33 INT72221 Localization of PRKCA 17 0.81 1.23 11.47
34 INT40486 Positive_regulation of Positive_regulation of ADCY1 20 0.48 4.29 11.33
35 INT126743 Positive_regulation of Gene_expression of LEP 61 0.66 50.02 11.17
36 INT82079 Positive_regulation of Lep 79 0.70 40 11.07
37 INT85017 Positive_regulation of Mc4r 13 0.67 7.56 10.86
38 INT4605 Negative_regulation of Gene_expression of INS 220 0.58 139.66 10.75
39 INT89184 Gene_expression of Mc4r 55 0.77 23.85 10.65
40 INT12620 Negative_regulation of Negative_regulation of ADCY1 16 0.44 2.98 10.1
41 INT101481 Positive_regulation of Lep 81 0.69 62.59 9.95
42 INT4494 Regulation of GCG 41 0.45 18.38 9.68
43 INT62919 Regulation of Gnas 22 0.43 5.61 9.55
44 INT26492 Negative_regulation of Localization of GCG 73 0.58 22.2 9.48
45 INT82078 Negative_regulation of Lep 54 0.59 20.47 9.38
46 INT68267 Gene_expression of CACNA1A 22 0.75 11.39 8.65
47 INT82082 Localization of Lep 63 0.81 26.41 8.56
48 INT75907 Binding of LEP 53 0.46 46.65 8.44
49 INT15529 Gene_expression of GCG 51 0.75 18.55 8.35
50 INT54681 Negative_regulation of Positive_regulation of ADCY1 16 0.38 2.7 8.14
51 INT64449 Negative_regulation of Gene_expression of Mc4r 7 0.58 2 7.86
52 INT298 Negative_regulation of ADRB3 23 0.59 6.82 7.56
53 INT4606 Regulation of Gene_expression of INS 67 0.61 54.69 7.53
54 INT75526 Positive_regulation of Positive_regulation of PRKCA 16 0.50 4.34 7.46
55 INT35584 Binding of ACLY 22 0.35 31.78 7.17
56 INT112986 Positive_regulation of S100b 19 0.70 17.61 6.86
57 INT21138 Binding of ADRA2A 16 0.48 5.57 6.8
58 INT72222 Positive_regulation of Localization of PRKCA 8 0.70 0.55 6.56
59 INT64444 Negative_regulation of Mc4r 9 0.58 5.12 6.44
60 INT11258 Gene_expression of Gnas 58 0.58 21.6 6.33
61 INT67635 Negative_regulation of Gnas 29 0.04 11.4 6.32
62 INT5678 Gene_expression of ADRA2C 17 0.74 2.62 6.24
63 INT15528 Positive_regulation of GCG 38 0.63 20.47 6.14
64 INT120335 Gene_expression of SNAP25 24 0.65 9.44 5.83
65 INT26919 Gene_expression of ITPR3 47 0.42 5.86 5.79
66 INT31227 Regulation of Localization of GCG 28 0.48 4.86 5.72
67 INT146594 Negative_regulation of Gene_expression of LEP 25 0.42 18.88 5.71
68 INT101482 Negative_regulation of Lep 53 0.54 33.59 5.65
69 INT18443 Positive_regulation of ADRA2C 12 0.69 2.61 5.48
70 INT85789 Gene_expression of Prlh 10 0.78 4.5 5.47
71 INT65356 Localization of LEP 46 0.79 41.17 5.43
72 INT91338 Binding of Lep 31 0.48 26.86 5.39
73 INT120339 Phosphorylation of SNAP25 5 0.51 2.97 5.3
74 INT80881 Phosphorylation of ADCY1 7 0.69 1.22 5.29
75 INT102935 Regulation of Lep 31 0.60 18.47 5.24
76 INT80038 Positive_regulation of Gene_expression of MYC 24 0.67 13.93 5.17
77 INT70800 Negative_regulation of Positive_regulation of PRKCA 9 0.34 2.18 5.17
78 INT26334 Localization of ITPR3 39 0.49 2.53 5.07
79 INT105609 Negative_regulation of Mc4r 10 0.58 10.4 5.04
80 INT14681 Negative_regulation of GCG 31 0.57 13.55 4.98
81 INT64446 Negative_regulation of Transcription of Mc4r 4 0.43 1.01 4.8
82 INT64441 Regulation of Transcription of Mc4r 3 0.27 2.93 4.62
83 INT166678 Negative_regulation of Phosphorylation of PRKCA 12 0.38 5.77 4.59
84 INT97391 Binding of Lep 18 0.48 8.97 4.47
85 INT14574 Positive_regulation of Negative_regulation of ADCY1 9 0.66 2.45 4.39
86 INT98357 Binding of Gnas 11 0.41 1.87 4.35
87 INT57642 Gene_expression of PCSK1 26 0.76 5.09 4.28
88 INT4104 Gene_expression of ADRB3 19 0.78 2.68 4.12
89 INT163581 Localization of Lep 27 0.79 18.99 4.08
90 INT17626 Positive_regulation of Localization of GCG 36 0.69 13.94 4.06
91 INT32933 Gene_expression of GNAS 57 0.32 10.58 4.03
92 INT89394 Phosphorylation of INS 37 0.82 35.84 3.9
93 INT13134 Binding of ADRA2C 11 0.46 0.73 3.86
94 INT109 Binding of ADRB3 17 0.47 3.02 3.84
95 INT287526 Negative_regulation of Gene_expression of CACNA1A 1 0.42 4.25 3.81
96 INT119606 Regulation of Gene_expression of LEP 17 0.45 17.96 3.75
97 INT26191 Positive_regulation of ITPR3 24 0.44 1.9 3.74
98 INT174054 Positive_regulation of Gene_expression of Lep 25 0.69 21.3 3.72
99 INT17379 Positive_regulation of Prlh 6 0.64 0.58 3.68
100 INT87408 Negative_regulation of ADCY2 3 0.01 0.1 3.68
101 INT16608 Positive_regulation of FFAR1 40 0.37 18.48 3.59
102 INT8781 Regulation of Prlh 6 0.45 0.67 3.58
103 INT65072 Gene_expression of TKT 16 0.65 17.58 3.55
104 INT82077 Positive_regulation of Gene_expression of Lep 32 0.70 17.9 3.5
105 INT87281 Localization of ADCY1 7 0.64 1.84 3.42
106 INT53516 Binding of CACNA1A 9 0.47 6.86 3.36
107 INT167913 Gene_expression of CACNA1C 3 0.75 0.38 3.34
108 INT20419 Negative_regulation of Gene_expression of MYC 19 0.57 9.7 3.29
109 INT72216 Regulation of Positive_regulation of PRKCA 9 0.37 1.36 3.26
110 INT120334 Negative_regulation of Phosphorylation of SNAP25 4 0.37 1.71 3.21
111 INT53495 Negative_regulation of Negative_regulation of PRKCA 4 0.42 2.37 3.18
112 INT77670 Positive_regulation of ACLY 24 0.49 21.68 3.12
113 INT66599 Gene_expression of MC4R 16 0.78 12.37 3.12
114 INT130441 Phosphorylation of MARCKS 8 0.37 3.24 3.09
115 INT78317 Regulation of CACNA1A 8 0.62 7.68 3.08
116 INT13179 Regulation of Positive_regulation of ADCY1 5 0.34 0.89 3.08
117 INT210838 Positive_regulation of Mc4r 17 0.53 6.79 3.06
118 INT59309 Negative_regulation of Gene_expression of ADCY1 3 0.42 1.04 2.98
119 INT73263 Negative_regulation of MYC 20 0.57 12.86 2.95
120 INT38987 Protein_catabolism of INS 21 0.99 11.92 2.91
121 INT32623 Negative_regulation of Regulation of INS 16 0.43 10.96 2.9
122 INT69641 Positive_regulation of ADCY2 5 0.32 0.18 2.87
123 INT85885 Positive_regulation of SNAP25 8 0.69 2.74 2.84
124 INT109833 Binding of GNB3 7 0.48 8.83 2.84
125 INT30815 Binding of ADCY1 7 0.36 0.21 2.79
126 INT171682 Positive_regulation of Phosphorylation of PRKCA 3 0.43 1.04 2.72
127 INT85787 Transcription of Prlh 4 0.53 1.77 2.7
128 INT130028 Positive_regulation of Gene_expression of Mc4r 2 0.45 0.41 2.7
129 INT97443 Positive_regulation of Positive_regulation of LEP 13 0.50 11.91 2.65
130 INT80884 Positive_regulation of Phosphorylation of ADCY1 4 0.43 0.24 2.64
131 INT11426 Positive_regulation of Gene_expression of ADCY1 5 0.29 0.68 2.63
132 INT26918 Positive_regulation of Gene_expression of ITPR3 14 0.27 2.31 2.41
133 INT103487 Positive_regulation of Positive_regulation of Lep 9 0.67 4.08 2.38
134 INT210833 Regulation of Mc4r 4 0.30 1.57 2.38
135 INT195085 Gene_expression of S100b 12 0.56 12.26 2.33
136 INT82798 Regulation of MYC 19 0.60 12.06 2.31
137 INT107685 Phosphorylation of MYC 3 0.80 2.52 2.28
138 INT3315 Negative_regulation of Positive_regulation of INS 31 0.57 14.73 2.27
139 INT26335 Binding of ITPR3 22 0.18 3.3 2.27
140 INT161575 Localization of CACNA1A 4 0.75 5.28 2.26
141 INT30372 Regulation of ADRB3 8 0.60 0.57 2.24
142 INT121543 Positive_regulation of Gene_expression of PCSK1 4 0.29 1.63 2.21
143 INT26177 Regulation of Regulation of INS 19 0.44 11.32 2.18
144 INT34500 Positive_regulation of ADRB3 12 0.58 2.59 2.16
145 INT73476 Transcription of MYC 18 0.69 12.14 2.13
146 INT14010 Gene_expression of SLC2A1 19 0.78 15.22 2.12
147 INT82081 Regulation of Gene_expression of Lep 11 0.53 7.78 2.12
148 INT101582 Negative_regulation of SNAP25 9 0.57 4.34 2.12
149 INT179311 Transcription of GNAS 2 0.10 0.67 2.08
150 INT108903 Negative_regulation of GNAS 7 0.57 1.58 2.04
151 INT83392 Transcription of Lep 6 0.54 5.07 2.04
152 INT106636 Binding of PRKCA 7 0.28 3.06 1.93
153 INT20421 Positive_regulation of MYC 19 0.67 10.43 1.9
154 INT23426 Regulation of ADRA2A 8 0.48 1.81 1.88
155 INT3866 Positive_regulation of Positive_regulation of INS 30 0.59 21.58 1.86
156 INT155110 Negative_regulation of Phosphorylation of MYC 1 0.57 1.61 1.83
157 INT115303 Localization of SNAP25 8 0.73 1.43 1.82
158 INT79569 Protein_catabolism of PRKCA 3 1.00 0.44 1.78
159 INT82083 Negative_regulation of Gene_expression of Lep 12 0.56 8.07 1.75
160 INT151790 Binding of SNAP25 11 0.24 1.09 1.73
161 INT101875 Binding of MC4R 6 0.47 0.19 1.73
162 INT97571 Positive_regulation of Gene_expression of PRKCA 13 0.43 1.61 1.7
163 INT75935 Regulation of MLXIPL 4 0.18 3.82 1.7
164 INT113897 Positive_regulation of Transcription of Mc4r 1 0.45 0 1.7
165 INT77415 Localization of GLP1R 23 0.63 11.1 1.69
166 INT28954 Binding of GCG 7 0.36 3.14 1.68
167 INT120505 Negative_regulation of ITPR3 6 0.27 1.46 1.68
168 INT73475 Positive_regulation of Transcription of MYC 7 0.67 5.46 1.66
169 INT26180 Regulation of Regulation of GCG 3 0.39 1.43 1.65
170 INT87289 Positive_regulation of Localization of ADCY1 3 0.43 0.36 1.65
171 INT178264 Positive_regulation of Gene_expression of Mc4r 10 0.43 3.52 1.57
172 INT85786 Localization of Prlh 3 0.75 0.87 1.57
173 INT80890 Negative_regulation of Phosphorylation of ADCY1 2 0.36 0.24 1.57
174 INT72310 Regulation of Regulation of ADCY1 6 0.24 1.24 1.55
175 INT43482 Regulation of Binding of ADRB3 4 0.60 1.06 1.54
176 INT43327 Positive_regulation of ADRA2A 3 0.46 1.54 1.53
177 INT242212 Gene_expression of GLP1R 29 0.65 11.36 1.52
178 INT17094 Negative_regulation of SLC25A4 3 0.41 3.82 1.52
179 INT14048 Negative_regulation of TKT 13 0.34 5.05 1.51
180 INT9953 Positive_regulation of Gnas 10 0.34 3.21 1.51
181 INT121347 Binding of GNAS 8 0.13 3.99 1.47
182 INT214115 Regulation of Gene_expression of Lep 9 0.61 7.37 1.44
183 INT52713 Regulation of Negative_regulation of PRKCA 5 0.36 1.23 1.41
184 INT181868 Localization of ACLY 5 0.62 6.36 1.4
185 INT162308 Phosphorylation of GNAS 3 0.01 1.71 1.4
186 INT5466 Positive_regulation of Negative_regulation of ADRB3 2 0.44 0.17 1.39
187 INT112988 Positive_regulation of Transcription of S100b 2 0.47 1.62 1.36
188 INT112987 Transcription of S100b 2 0.53 1.61 1.35
189 INT148562 Positive_regulation of GNAS 13 0.16 5.31 1.32
190 INT55318 Localization of ADRA2C 3 0.73 1.39 1.3
191 INT20418 Regulation of Gene_expression of MYC 6 0.60 4.4 1.29
192 INT264798 Binding of GLP1R 9 0.40 2.95 1.27
193 INT80887 Negative_regulation of Regulation of ADCY1 3 0.35 0.1 1.26
194 INT36226 Gene_expression of GIP 13 0.67 3.05 1.25
195 INT235401 Negative_regulation of Gene_expression of ITPR3 4 0.20 1.69 1.24
196 INT109104 Positive_regulation of Protein_catabolism of INS 4 0.50 4.44 1.24
197 INT220763 Regulation of Phosphorylation of PRKCA 3 0.29 0.84 1.22
198 INT145960 Positive_regulation of GLP1R 19 0.58 7.25 1.19
199 INT167270 Negative_regulation of Gene_expression of Lep 13 0.55 5.48 1.19
200 INT120337 Positive_regulation of Phosphorylation of SNAP25 2 0.29 0.11 1.19
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