GO:0006139

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Name nucleobase-containing compound metabolic process
Categary Process
Go Slim No
Go Link GO:0006139
Unique Molecular Interactions 104
Total Molecular Interactions 133
Total Single Events 1729
Pain Genes Associated 17

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for nucleobase-containing compound metabolic process. They are ordered first by their pain relevance and then by number of times they were reported for nucleobase-containing compound metabolic process. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT73116 TYMS Negative_regulation of DNMT3B 1 0.24 0 1.6
2 INT73115 TYMS Negative_regulation of Positive_regulation of DNMT3B 1 0.24 0 1.6
3 INT253863 Binding of LBP and PNP 1 0.13 1.5 1.5
4 INT72213 Positive_regulation of PRKCA Regulation of Gene_expression of METTL3 1 0.05 0.17 0.93
5 INT187522 ATIC Negative_regulation of Gene_expression of Nos2 1 0.02 1.46 0.7
6 INT122823 ERCC2 Regulation of Negative_regulation of OPRM1 1 0.23 0.17 0.63
7 INT96228 COX5A Regulation of Ak1 1 0.01 0.6 0.6
8 INT231303 Binding of Prnp and Helt 1 0.02 3.23 0.41
9 INT189681 Negative_regulation of PRKCA Negative_regulation of Gene_expression of METTL3 1 0.00 0.16 0.41
10 INT231304 Prnp Negative_regulation of Grin2d 2 0.38 0.5 0.4
11 INT187519 ATIC Negative_regulation of Gene_expression of Ros1 1 0.00 1.48 0.39
12 INT13715 PDYN Positive_regulation of TYMS 1 0.27 0 0.39
13 INT187521 ATIC Positive_regulation of Prkag1 1 0.01 1.07 0.37
14 INT142947 Binding of ERCC2 and OPRM1 1 0.05 0.3 0.32
15 INT231306 Prnp Regulation of Grin1 1 0.60 0.35 0.31
16 INT187518 Positive_regulation of ATIC Positive_regulation of Prkag1 1 0.01 0.99 0.25
17 INT231305 Positive_regulation of Binding of Prnp and Helt 1 0.03 1.63 0.19
18 INT69949 Car2 Positive_regulation of MTAP 1 0.02 0.41 0.18
19 INT299495 EXOSC10 Regulation of IL6 1 0.01 0.59 0.17
20 INT302295 PPARA Regulation of OAS2 1 0.01 0.72 0.17
21 INT299496 EXOSC10 Regulation of CSRP1 1 0.00 0.59 0.17
22 INT302930 Binding of Pnp and Chrm2 1 0.00 0.64 0.15
23 INT134698 Regulation of Prnp Positive_regulation of Nup214 1 0.26 1.18 0.14
24 INT103557 Binding of ERCC2 and TP53 1 0.40 1 0.13
25 INT134697 Prnp Positive_regulation of Nup214 1 0.44 1.18 0.13
26 INT231301 Prnp Regulation of Regulation of Grin1 1 0.26 0.24 0.08
27 INT299491 Binding of IL6 and EXOSC10 1 0.01 0.44 0.08
28 INT207310 Pik3r1 Positive_regulation of Prnp 1 0.36 0.65 0.08
29 INT31987 NTS Positive_regulation of Binding of GDA 1 0.50 0 0.08
30 INT229539 Cpz Negative_regulation of Localization of Prnp 1 0.05 0.58 0.07
31 INT229538 Cpz Negative_regulation of Positive_regulation of Prnp 1 0.05 0.58 0.07
32 INT231300 Positive_regulation of Grin2b Positive_regulation of Prnp 1 0.39 0.16 0.05
33 INT267152 Binding of LEP and DDX12P 1 0.00 0.69 0.05
34 INT231299 Prnp Regulation of Grin2d 1 0.28 0 0.05
35 INT231302 Binding of Grin2d and Prnp 1 0.38 0.11 0.05
36 INT329226 Negative_regulation of ATIC Positive_regulation of Psmd9 1 0.01 0.58 0.04
37 INT253413 ATIC Positive_regulation of Gene_expression of Prkaa2 1 0.02 0 0.04
38 INT329229 ATIC Positive_regulation of Tpt1 1 0.01 0.58 0.04
39 INT329230 Negative_regulation of ATIC Positive_regulation of Trp53 1 0.00 0.58 0.04
40 INT253417 ATIC Positive_regulation of Prkaa2 1 0.02 0.31 0.04
41 INT329231 ATIC Positive_regulation of Psmd9 1 0.01 0.58 0.04
42 INT329228 ATIC Positive_regulation of Trp53 1 0.01 0.58 0.04
43 INT329227 Negative_regulation of ATIC Positive_regulation of Tpt1 1 0.01 0.58 0.04
44 INT191923 Binding of EXOSC10 and Tlr4 1 0.21 0.48 0.04
45 INT187520 ATIC Positive_regulation of Phosphorylation of Prkag1 1 0.01 0 0.03
46 INT231311 Prnp Negative_regulation of Helt 1 0.04 0.05 0.03
47 INT253415 ATIC Regulation of Phosphorylation of Prkaa2 1 0.03 0 0.03
48 INT253418 ATIC Regulation of Prkaa2 1 0.02 0 0.03
49 INT231308 Prnp Negative_regulation of Gene_expression of Grin1 1 0.41 0.05 0.03
50 INT253416 ATIC Negative_regulation of Phosphorylation of Eif4ebp1 1 0.00 0 0.03
51 INT253411 ATIC Negative_regulation of Eif4ebp1 1 0.00 0 0.03
52 INT231312 Prnp Negative_regulation of Grin1 1 0.42 0.05 0.03
53 INT253412 ATIC Negative_regulation of Rps6kb1 1 0.02 0 0.03
54 INT191899 Binding of EXOSC10 and PNN 1 0.00 0.96 0.03
55 INT260518 Binding of Prnp and Gopc 2 0.13 1.06 0
56 INT268647 ATP2B3 Positive_regulation of Prnp 1 0.01 0.57 0
57 INT335952 Prnp Positive_regulation of can 1 0.17 0.58 0
58 INT320351 Pnp Regulation of Ighg2b 1 0.02 0.31 0
59 INT275231 Binding of ACVRL1 and AK3 1 0.01 0.72 0
60 INT268183 Gene_expression of Rab22a Negative_regulation of Gene_expression of Prnp 1 0.28 0.1 0
61 INT297245 Prnp Positive_regulation of Notch1 1 0.21 0.73 0
62 INT260523 Binding of Cnp and Prnp 1 0.33 0.34 0
63 INT86001 Binding of Pnp and Alms1 1 0.03 0 0
64 INT234180 Binding of BRCA1 and BRIP1 1 0.33 1.37 0
65 INT268192 Gene_expression of Rab22a Positive_regulation of Protein_catabolism of Prnp 1 0.30 0.08 0
66 INT260519 Binding of Prnp and Scarb1 1 0.41 0.21 0
67 INT268191 Rab4a Regulation of Gene_expression of Prnp 1 0.23 0.22 0
68 INT290022 Binding of PPARG and DDX12P 1 0.00 1.77 0
69 INT260522 Binding of Myc and Prnp 1 0.30 0.35 0
70 INT320352 Pnp Positive_regulation of Ighg2b 1 0.03 0.08 0
71 INT335950 Negative_regulation of Prnp Positive_regulation of can 1 0.16 0.59 0
72 INT268197 Gene_expression of Rab22a Regulation of Prnp 1 0.29 0.08 0
73 INT191900 Binding of EXOSC10 and COPD 1 0.01 0.53 0
74 INT302926 Binding of Pnp and Pbrm1 1 0.01 0.96 0
75 INT268184 Prnp Regulation of Gene_expression of Rab22a 1 0.34 0.17 0
76 INT231313 Prnp Positive_regulation of Grin2d 1 0.47 0.16 0
77 INT268201 Tg(CAG-EGFP)D4Nagy Regulation of Prnp 1 0.01 0.22 0
78 INT268198 Prnp Positive_regulation of Erc1 1 0.04 0.26 0
79 INT268194 Erc1 Positive_regulation of Gene_expression of Prnp 1 0.05 0.2 0
80 INT232056 Binding of DDR1 and PNP 1 0.01 0.55 0
81 INT149429 ERCC2 Negative_regulation of Localization of IL8 1 0.05 0.38 0
82 INT189110 Binding of Pnp and Asprv1 1 0.00 0 0
83 INT268190 Gene_expression of Rab22a Negative_regulation of Prnp 1 0.32 0.08 0
84 INT268177 Rab4a Regulation of Prnp 1 0.14 0.22 0
85 INT227840 Binding of ERCC2 and ERCC6 1 0.11 0.66 0
86 INT268182 Positive_regulation of Binding of Prnp and Erc1 1 0.06 0.1 0
87 INT274387 Binding of POLA1 and IGSF9 1 0.01 0.58 0
88 INT302929 Binding of Pnp and Spna1 1 0.00 0.35 0
89 INT149431 ERCC2 Negative_regulation of Localization of Il6 1 0.14 0.2 0
90 INT227831 Binding of ERCC2 and PGBD3 1 0.07 0.23 0
91 INT351614 APRT Positive_regulation of MTAP 1 0.00 0.22 0
92 INT253410 ATIC Regulation of Lep 1 0.03 0.7 0
93 INT268188 Binding of Prnp and Erc1 1 0.04 0.27 0
94 INT351615 MTAP Positive_regulation of Gene_expression of OR4G6P 1 0.00 0.22 0
95 INT268185 Rab22a Negative_regulation of Gene_expression of Prnp 1 0.32 0.08 0
96 INT147144 E2F1 Positive_regulation of Transcription of TYMS 1 0.26 0 0
97 INT149432 ERCC2 Regulation of Localization of Il6 1 0.15 1.06 0
98 INT149428 ERCC2 Regulation of Localization of IL8 1 0.05 0.53 0
99 INT268195 Rab22a Negative_regulation of Prnp 1 0.44 0.09 0
100 INT268176 Positive_regulation of Erc1 Positive_regulation of Gene_expression of Prnp 1 0.06 0.2 0
101 INT287034 Pgp Regulation of Positive_regulation of Prnp 1 0.13 0.09 0
102 INT268646 Prnp Positive_regulation of PRNP 1 0.08 0.42 0
103 INT315814 Tst Positive_regulation of Localization of RTEL1 1 0.02 2.19 0
104 INT354482 Binding of PRNP and Prnp 1 0.16 0.88 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for nucleobase-containing compound metabolic process. They are ordered first by their pain relevance and then by number of times they were reported in nucleobase-containing compound metabolic process. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT102112 Gene_expression of Prnp 440 0.78 209.32 22.5
2 INT69569 Positive_regulation of Prnp 175 0.70 96.31 13.34
3 INT72219 Gene_expression of METTL3 45 0.24 9.58 7.61
4 INT253864 Negative_regulation of PNP 13 0.26 6.84 6.67
5 INT103899 Gene_expression of ERCC2 14 0.65 7.85 5.49
6 INT69572 Localization of Prnp 96 0.81 38.11 5.45
7 INT102254 Positive_regulation of Gene_expression of Prnp 72 0.70 38.11 4.81
8 INT69570 Binding of Prnp 75 0.48 44.26 4.37
9 INT102255 Regulation of Prnp 35 0.62 18.97 3.25
10 INT174232 Gene_expression of PNP 36 0.30 8.74 3.17
11 INT102253 Negative_regulation of Prnp 75 0.59 24.23 2.62
12 INT135040 Regulation of Gene_expression of Prnp 30 0.62 10.52 2.45
13 INT213681 Gene_expression of TYMS 9 0.33 8.96 2.45
14 INT44979 Positive_regulation of Pnp 11 0.59 5.61 2.41
15 INT68443 Positive_regulation of METTL3 9 0.12 3.54 2.39
16 INT85178 Gene_expression of OAS2 10 0.21 4.17 1.93
17 INT187492 Positive_regulation of ATIC 9 0.05 1.74 1.88
18 INT213676 Negative_regulation of Gene_expression of TYMS 2 0.08 1.95 1.83
19 INT174240 Negative_regulation of TYMS 12 0.57 6.35 1.82
20 INT187489 Localization of ATIC 1 0.07 4.03 1.81
21 INT40322 Binding of Pnp 12 0.38 11.13 1.78
22 INT103900 Positive_regulation of ERCC2 7 0.58 3.47 1.78
23 INT187494 Gene_expression of ATIC 6 0.06 5.45 1.27
24 INT72218 Regulation of METTL3 5 0.08 1.62 1.14
25 INT142950 Protein_catabolism of ERCC2 2 0.25 1.45 1.14
26 INT72215 Regulation of Gene_expression of METTL3 2 0.08 0.25 1.04
27 INT204737 Negative_regulation of Gene_expression of Prnp 32 0.59 18.96 1.03
28 INT37080 Negative_regulation of OAS2 4 0.05 1.3 0.89
29 INT72220 Negative_regulation of METTL3 6 0.10 1.76 0.88
30 INT58405 Gene_expression of GDA 3 0.75 0.24 0.86
31 INT136634 Transcription of Prnp 9 0.72 3.34 0.83
32 INT117083 Localization of RTEL1 5 0.60 9.1 0.8
33 INT27832 Positive_regulation of Ak1 5 0.46 0.96 0.77
34 INT239499 Positive_regulation of Positive_regulation of ATIC 1 0.05 0.53 0.77
35 INT86779 Gene_expression of Ak1 3 0.01 1.12 0.71
36 INT190662 Regulation of Positive_regulation of Prnp 4 0.24 1.15 0.7
37 INT69571 Positive_regulation of Positive_regulation of Prnp 6 0.70 5.88 0.67
38 INT4344 Positive_regulation of MTAP 2 0.19 1.83 0.67
39 INT50440 Negative_regulation of Pnp 5 0.36 2.14 0.66
40 INT151745 Negative_regulation of Gene_expression of METTL3 2 0.11 0.58 0.64
41 INT93752 Positive_regulation of OAS2 2 0.13 0.67 0.64
42 INT100941 Positive_regulation of Gene_expression of OAS2 2 0.16 0.53 0.6
43 INT96227 Regulation of Ak1 1 0.01 0.6 0.6
44 INT42882 Positive_regulation of GDA 2 0.45 1.26 0.58
45 INT191905 Binding of EXOSC10 19 0.04 11.24 0.57
46 INT191904 Positive_regulation of EXOSC10 11 0.06 5.43 0.57
47 INT134070 Binding of ERCC2 3 0.27 0.76 0.51
48 INT186882 Gene_expression of RTEL1 13 0.27 13.45 0.49
49 INT187491 Phosphorylation of ATIC 6 0.07 1.67 0.49
50 INT13717 Positive_regulation of TYMS 3 0.40 1.64 0.49
51 INT69947 Negative_regulation of MTAP 5 0.40 2.63 0.48
52 INT168045 Negative_regulation of ATIC 3 0.10 1.2 0.48
53 INT187557 Localization of METTL3 1 0.01 2.3 0.47
54 INT186542 Regulation of MTAP 3 0.06 1.66 0.46
55 INT124164 Protein_catabolism of Prnp 20 1.00 8.58 0.44
56 INT144002 Positive_regulation of Gene_expression of METTL3 2 0.02 0.16 0.44
57 INT148087 Positive_regulation of RTEL1 9 0.17 5.13 0.41
58 INT226818 Negative_regulation of RTEL1 1 0.06 1.17 0.41
59 INT103901 Regulation of ERCC2 1 0.23 0.51 0.4
60 INT201844 Transcription of GDA 1 0.05 1.2 0.38
61 INT201848 Negative_regulation of GDA 1 0.06 1.21 0.38
62 INT201849 Negative_regulation of Transcription of GDA 1 0.04 1.21 0.38
63 INT86778 Positive_regulation of Gene_expression of Ak1 1 0.00 0.29 0.37
64 INT338169 Binding of MTAP 1 0.36 0.76 0.37
65 INT189726 Positive_regulation of Positive_regulation of METTL3 1 0.01 0.16 0.36
66 INT126817 Phosphorylation of GDA 1 0.79 0 0.35
67 INT68442 Transcription of METTL3 2 0.03 0.98 0.29
68 INT229518 Phosphorylation of Prnp 5 0.69 1.62 0.27
69 INT331055 Positive_regulation of Phosphorylation of Prnp 1 0.07 0.24 0.27
70 INT136760 Regulation of OAS2 1 0.01 0.21 0.27
71 INT69568 Positive_regulation of Localization of Prnp 5 0.50 2.43 0.26
72 INT268171 Negative_regulation of Binding of Prnp 3 0.42 0.82 0.25
73 INT237464 Positive_regulation of Negative_regulation of TYMS 2 0.20 0.53 0.23
74 INT169061 Gene_expression of Pnp 19 0.66 9.39 0.21
75 INT169062 Positive_regulation of Gene_expression of Pnp 6 0.49 3.6 0.21
76 INT187554 Positive_regulation of Transcription of METTL3 1 0.01 0.98 0.21
77 INT44173 Regulation of GDA 1 0.44 0 0.19
78 INT267166 Binding of DDX12P 1 0.01 3.34 0.18
79 INT27344 Localization of Ak1 3 0.56 1.84 0.12
80 INT279806 Regulation of TYMS 2 0.05 1 0.12
81 INT343804 Protein_catabolism of METTL3 1 0.01 0.65 0.12
82 INT187490 Regulation of ATIC 1 0.04 0 0.11
83 INT190664 Regulation of Binding of Prnp 3 0.52 4.29 0.1
84 INT207304 Positive_regulation of Protein_catabolism of Prnp 9 0.69 2.08 0.09
85 INT191908 Negative_regulation of Positive_regulation of EXOSC10 1 0.01 0.25 0.09
86 INT169060 Negative_regulation of Gene_expression of Pnp 3 0.42 0.95 0.08
87 INT187493 Binding of ATIC 1 0.04 0.07 0.08
88 INT284491 Binding of METTL3 1 0.01 0.78 0.08
89 INT211097 Negative_regulation of Binding of Pnp 1 0.08 1.27 0.08
90 INT31988 Binding of GDA 1 0.36 0 0.08
91 INT186543 Gene_expression of MTAP 1 0.11 0.48 0.08
92 INT191906 Positive_regulation of Positive_regulation of EXOSC10 2 0.04 0.66 0.07
93 INT351855 Negative_regulation of Ak1 1 0.06 0.44 0.07
94 INT81390 Positive_regulation of Localization of Ak1 1 0.01 0 0.07
95 INT200136 Negative_regulation of ERCC2 1 0.37 1.91 0.07
96 INT147148 Transcription of TYMS 2 0.30 0.5 0.06
97 INT237463 Regulation of Gene_expression of TYMS 1 0.12 0.51 0.06
98 INT237466 Regulation of Transcription of TYMS 1 0.26 0.5 0.06
99 INT207302 Positive_regulation of Transcription of Prnp 1 0.47 0.71 0.06
100 INT229516 Negative_regulation of Positive_regulation of Prnp 5 0.42 0.95 0.04
101 INT218757 Regulation of Pnp 4 0.15 5.51 0.04
102 INT288233 Localization of TYMS 2 0.22 2.17 0.04
103 INT288232 Binding of TYMS 2 0.11 2.77 0.04
104 INT229519 Regulation of Localization of Prnp 4 0.61 0.7 0.03
105 INT315806 Phosphorylation of RTEL1 1 0.04 0.68 0.03
106 INT287031 Positive_regulation of Negative_regulation of Prnp 1 0.46 0.16 0.03
107 INT291906 Positive_regulation of Negative_regulation of ERCC2 1 0.40 0 0.03
108 INT186878 Binding of RTEL1 7 0.12 4.75 0
109 INT210093 Gene_expression of EXOSC10 5 0.65 2.31 0
110 INT268144 Negative_regulation of Localization of Prnp 3 0.37 0.71 0
111 INT232066 Binding of PNP 3 0.13 0.28 0
112 INT190666 Positive_regulation of Binding of Prnp 2 0.50 1.87 0
113 INT268161 Regulation of Negative_regulation of Prnp 2 0.39 0.33 0
114 INT232073 Regulation of PNP 2 0.12 0.33 0
115 INT174238 Positive_regulation of Gene_expression of PNP 2 0.16 0.69 0
116 INT315808 Positive_regulation of Protein_catabolism of RTEL1 1 0.03 0.98 0
117 INT280520 Regulation of Gene_expression of Pnp 1 0.15 0.55 0
118 INT315810 Positive_regulation of Gene_expression of RTEL1 1 0.03 1.77 0
119 INT310442 Gene_expression of POLA1 1 0.30 0.97 0
120 INT256198 Positive_regulation of Gene_expression of EXOSC10 1 0.49 0.56 0
121 INT326142 Positive_regulation of Gene_expression of TYMS 1 0.16 2.47 0
122 INT186880 Regulation of RTEL1 1 0.11 0.54 0
123 INT93751 Negative_regulation of Positive_regulation of OAS2 1 0.11 0.05 0
124 INT315811 Negative_regulation of Binding of RTEL1 1 0.02 0.86 0
125 INT229517 Regulation of Phosphorylation of Prnp 1 0.39 0.26 0
126 INT147145 Negative_regulation of Transcription of TYMS 1 0.15 0 0
127 INT191907 Positive_regulation of Binding of EXOSC10 1 0.01 0.36 0
128 INT210091 Regulation of EXOSC10 1 0.04 0.54 0
129 INT210094 Negative_regulation of EXOSC10 1 0.03 0.15 0
130 INT315970 Regulation of Gene_expression of RTEL1 1 0.03 1.35 0
131 INT285458 Negative_regulation of Gene_expression of PNP 1 0.11 0 0
132 INT310440 Positive_regulation of POLA1 1 0.18 0.09 0
133 INT285456 Positive_regulation of PNP 1 0.13 0.08 0
134 INT186879 Positive_regulation of Positive_regulation of RTEL1 1 0.12 0.29 0
135 INT285457 Localization of PNP 1 0.21 0 0
136 INT234190 Gene_expression of BRIP1 1 0.55 0.6 0
137 INT320332 Transcription of Pnp 1 0.05 0.05 0
138 INT149430 Localization of ERCC2 1 0.43 0.76 0
139 INT315807 Protein_catabolism of RTEL1 1 0.05 0.84 0
140 INT302919 Negative_regulation of Regulation of Pnp 1 0.04 1.71 0
141 INT310439 Regulation of POLA1 1 0.24 2.21 0
142 INT310443 Negative_regulation of POLA1 1 0.16 0.31 0
143 INT315809 Regulation of Protein_catabolism of RTEL1 1 0.03 0.97 0
144 INT315971 Transcription of RTEL1 1 0.04 1.28 0
145 INT290039 Gene_expression of DDX12P 1 0.00 1.41 0
146 INT352864 Regulation of BRIP1 1 0.51 0.13 0
147 INT315417 Negative_regulation of Transcription of Prnp 1 0.43 0.14 0
148 INT268173 Negative_regulation of Negative_regulation of Prnp 1 0.37 0 0
149 INT186881 Positive_regulation of Binding of RTEL1 1 0.12 0.5 0
150 INT268148 Regulation of Protein_catabolism of Prnp 1 0.45 0 0
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