GO:0006144

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Name purine base metabolic process
Categary Process
Go Slim No
Go Link GO:0006144
Unique Molecular Interactions 62
Total Molecular Interactions 76
Total Single Events 957
Pain Genes Associated 15

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for purine base metabolic process. They are ordered first by their pain relevance and then by number of times they were reported for purine base metabolic process. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT279359 Binding of ADA and TNF 1 0.20 2.61 1.91
2 INT253863 Binding of LBP and PNP 1 0.13 1.5 1.5
3 INT42580 CAT Negative_regulation of POMC 1 0.20 0.42 1.26
4 INT164722 Avp Regulation of NT5C 1 0.06 0.88 1.15
5 INT287132 Binding of NT5E and Comt 1 0.03 0.11 0.73
6 INT187522 ATIC Negative_regulation of Gene_expression of Nos2 1 0.02 1.46 0.7
7 INT164721 Binding of NT5C and Acot1 1 0.04 0.45 0.65
8 INT164723 Binding of Avp and NT5C 1 0.07 0.45 0.65
9 INT150965 NT5C2 Positive_regulation of PRKG1 1 0.04 0.07 0.62
10 INT84861 Rps6ka3 Positive_regulation of Transcription of APRT 1 0.28 0.19 0.55
11 INT279360 ADA Negative_regulation of Gene_expression of IFNG 1 0.06 0.51 0.44
12 INT187519 ATIC Negative_regulation of Gene_expression of Ros1 1 0.00 1.48 0.39
13 INT187521 ATIC Positive_regulation of Prkag1 1 0.01 1.07 0.37
14 INT279369 Binding of ADA and Ifx 1 0.29 0.27 0.35
15 INT5388 PTGS1 Negative_regulation of APRT 1 0.21 0.4 0.34
16 INT135891 S1pr1 Regulation of Prps1 1 0.01 0.15 0.33
17 INT187518 Positive_regulation of ATIC Positive_regulation of Prkag1 1 0.01 0.99 0.25
18 INT287131 Negative_regulation of Binding of NT5E and Comt 1 0.03 0.06 0.23
19 INT183247 ADA Negative_regulation of ADORA1 1 0.01 0 0.23
20 INT194537 Binding of PAEP and Uox 1 0.10 1.12 0.14
21 INT287130 Positive_regulation of Binding of NT5E and Comt 1 0.04 0 0.12
22 INT62775 Regulation of Binding of NT5E and OPRK1 1 0.03 0 0.1
23 INT186246 Binding of CAT and SCN5A 1 0.03 0.47 0.1
24 INT305534 Binding of HPRT1 and Tg(CAG-EGFP)D4Nagy 1 0.03 0.7 0.1
25 INT62776 Binding of NT5E and OPRK1 1 0.02 0 0.1
26 INT186245 Binding of AGRP and CAT 1 0.02 0.53 0.1
27 INT305535 Binding of HPRT1 and Runx1 1 0.41 0.7 0.1
28 INT157263 PPARA Positive_regulation of APRT 1 0.54 0.92 0.08
29 INT31987 NTS Positive_regulation of Binding of GDA 1 0.50 0 0.08
30 INT157272 Adipor1 Positive_regulation of APRT 1 0.12 0.88 0.07
31 INT166919 Binding of CAT and GSTK1 1 0.09 0.16 0.07
32 INT267998 Binding of XDH and Nos1 1 0.02 0.46 0.06
33 INT329226 Negative_regulation of ATIC Positive_regulation of Psmd9 1 0.01 0.58 0.04
34 INT253413 ATIC Positive_regulation of Gene_expression of Prkaa2 1 0.02 0 0.04
35 INT329229 ATIC Positive_regulation of Tpt1 1 0.01 0.58 0.04
36 INT329230 Negative_regulation of ATIC Positive_regulation of Trp53 1 0.00 0.58 0.04
37 INT253417 ATIC Positive_regulation of Prkaa2 1 0.02 0.31 0.04
38 INT329231 ATIC Positive_regulation of Psmd9 1 0.01 0.58 0.04
39 INT329228 ATIC Positive_regulation of Trp53 1 0.01 0.58 0.04
40 INT329227 Negative_regulation of ATIC Positive_regulation of Tpt1 1 0.01 0.58 0.04
41 INT252767 CAT Regulation of Gpx1 1 0.00 0.25 0.04
42 INT187520 ATIC Positive_regulation of Phosphorylation of Prkag1 1 0.01 0 0.03
43 INT253415 ATIC Regulation of Phosphorylation of Prkaa2 1 0.03 0 0.03
44 INT253418 ATIC Regulation of Prkaa2 1 0.02 0 0.03
45 INT311144 CAT Positive_regulation of APRT 1 0.01 0 0.03
46 INT253416 ATIC Negative_regulation of Phosphorylation of Eif4ebp1 1 0.00 0 0.03
47 INT253411 ATIC Negative_regulation of Eif4ebp1 1 0.00 0 0.03
48 INT253412 ATIC Negative_regulation of Rps6kb1 1 0.02 0 0.03
49 INT218308 Binding of HPRT1 and Grb10 1 0.26 0.07 0
50 INT285403 Binding of CAT and MPO 1 0.30 0.9 0
51 INT311145 CAT Positive_regulation of Protein_catabolism of APRT 1 0.01 0 0
52 INT36328 Binding of AMPD1 and Hmgcl 1 0.01 1.02 0
53 INT351623 APRT Positive_regulation of Pfkm 1 0.00 0.15 0
54 INT232056 Binding of DDR1 and PNP 1 0.01 0.55 0
55 INT273495 GBP4 Negative_regulation of IMPDH1 1 0.03 0.2 0
56 INT312950 Binding of ADA and HBN1 1 0.01 0.49 0
57 INT351614 APRT Positive_regulation of MTAP 1 0.00 0.22 0
58 INT253410 ATIC Regulation of Lep 1 0.03 0.7 0
59 INT194538 Binding of PAEP and Negative_regulation of Uox 1 0.13 0.31 0
60 INT194539 UOX Positive_regulation of Gene_expression of Uox 1 0.39 0.21 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for purine base metabolic process. They are ordered first by their pain relevance and then by number of times they were reported in purine base metabolic process. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT22132 Positive_regulation of CAT 41 0.67 18.64 10.67
2 INT11238 Positive_regulation of ADA 33 0.70 39.7 9.98
3 INT4228 Gene_expression of CAT 50 0.75 20.62 7.18
4 INT24800 Negative_regulation of AMPD1 44 0.59 21.19 6.76
5 INT253864 Negative_regulation of PNP 13 0.26 6.84 6.67
6 INT30206 Negative_regulation of ADA 17 0.59 10.03 5.63
7 INT35536 Negative_regulation of CAT 26 0.57 14.39 5.38
8 INT68202 Gene_expression of ADA 26 0.68 23.15 5.18
9 INT134590 Localization of ADA 7 0.65 8.43 3.96
10 INT62784 Gene_expression of NT5E 46 0.65 15.95 3.72
11 INT72798 Binding of ADA 12 0.47 7.84 3.39
12 INT174232 Gene_expression of PNP 36 0.30 8.74 3.17
13 INT131494 Regulation of ADA 8 0.52 7.37 2.97
14 INT41545 Negative_regulation of APRT 8 0.57 2.99 2.88
15 INT14902 Negative_regulation of XDH 38 0.55 24.19 2.86
16 INT22129 Positive_regulation of Gene_expression of CAT 11 0.67 4.23 2.37
17 INT29393 Positive_regulation of APRT 18 0.67 5.28 2.13
18 INT57115 Negative_regulation of NT5E 8 0.57 4.35 2.03
19 INT3496 Negative_regulation of HPRT1 7 0.58 25.05 1.92
20 INT48035 Positive_regulation of NT5C2 5 0.67 2.42 1.91
21 INT187492 Positive_regulation of ATIC 9 0.05 1.74 1.88
22 INT187489 Localization of ATIC 1 0.07 4.03 1.81
23 INT26416 Regulation of APRT 2 0.44 0.67 1.74
24 INT38931 Localization of APRT 3 0.78 0.87 1.7
25 INT88726 Gene_expression of HPRT1 36 0.78 10.12 1.58
26 INT3892 Positive_regulation of XDH 8 0.67 8.57 1.5
27 INT181873 Regulation of Localization of ADA 1 0.07 1.98 1.41
28 INT164720 Positive_regulation of Localization of NT5C 1 0.06 0.87 1.39
29 INT96420 Positive_regulation of NT5E 9 0.49 3.7 1.38
30 INT155036 Localization of NT5E 6 0.73 4.1 1.35
31 INT110569 Gene_expression of XDH 31 0.75 18.35 1.34
32 INT187494 Gene_expression of ATIC 6 0.06 5.45 1.27
33 INT91122 Localization of CAT 6 0.78 4.13 1.19
34 INT192073 Positive_regulation of Gene_expression of ADA 8 0.47 10.35 1.12
35 INT53682 Regulation of Gene_expression of CAT 2 0.60 0.36 0.96
36 INT44122 Positive_regulation of AMPD1 4 0.44 1.88 0.92
37 INT66314 Negative_regulation of Positive_regulation of CAT 4 0.42 0.8 0.91
38 INT1189 Gene_expression of AMPD1 7 0.59 4.1 0.9
39 INT58405 Gene_expression of GDA 3 0.75 0.24 0.86
40 INT132912 Phosphorylation of APRT 2 0.61 0.63 0.84
41 INT239499 Positive_regulation of Positive_regulation of ATIC 1 0.05 0.53 0.77
42 INT287128 Protein_catabolism of NT5E 2 0.11 0.64 0.76
43 INT279366 Positive_regulation of Localization of ADA 2 0.42 4.37 0.76
44 INT132914 Positive_regulation of Phosphorylation of APRT 1 0.45 0 0.75
45 INT57008 Positive_regulation of HPRT1 11 0.50 2.81 0.74
46 INT294133 Regulation of Gene_expression of NT5E 4 0.12 1.36 0.71
47 INT164717 Localization of NT5C 1 0.09 0.43 0.69
48 INT150966 Positive_regulation of Positive_regulation of NT5C2 1 0.49 0.07 0.63
49 INT164718 Regulation of NT5C 3 0.19 1.36 0.62
50 INT210028 Protein_catabolism of ADA 1 0.07 0.13 0.62
51 INT107417 Regulation of CAT 8 0.60 2.4 0.61
52 INT155035 Binding of NT5E 3 0.36 1.78 0.61
53 INT42882 Positive_regulation of GDA 2 0.45 1.26 0.58
54 INT164719 Regulation of Regulation of NT5C 1 0.03 0.44 0.58
55 INT32062 Regulation of Negative_regulation of AMPD1 1 0.14 0.5 0.58
56 INT130387 Binding of CAT 4 0.36 2.39 0.55
57 INT84859 Transcription of APRT 1 0.69 0.19 0.55
58 INT84860 Negative_regulation of Transcription of APRT 1 0.42 0.19 0.55
59 INT200072 Gene_expression of APRT 8 0.65 1 0.54
60 INT179373 Localization of XDH 3 0.20 1.97 0.54
61 INT119483 Negative_regulation of Gene_expression of AMPD1 2 0.04 1.95 0.5
62 INT187491 Phosphorylation of ATIC 6 0.07 1.67 0.49
63 INT168045 Negative_regulation of ATIC 3 0.10 1.2 0.48
64 INT251661 Phosphorylation of NT5E 2 0.21 1.59 0.46
65 INT143683 Negative_regulation of Gene_expression of ADA 1 0.09 0.28 0.44
66 INT194521 Negative_regulation of Uox 7 0.52 4.93 0.41
67 INT96419 Positive_regulation of Gene_expression of NT5E 3 0.49 1.46 0.41
68 INT201844 Transcription of GDA 1 0.05 1.2 0.38
69 INT201848 Negative_regulation of GDA 1 0.06 1.21 0.38
70 INT201849 Negative_regulation of Transcription of GDA 1 0.04 1.21 0.38
71 INT84981 Negative_regulation of Gene_expression of CAT 3 0.41 0.35 0.35
72 INT126817 Phosphorylation of GDA 1 0.79 0 0.35
73 INT20856 Binding of APRT 2 0.36 0 0.34
74 INT135888 Gene_expression of Prps1 1 0.03 0.21 0.34
75 INT279365 Regulation of Regulation of ADA 1 0.23 0 0.33
76 INT287129 Regulation of NT5E 3 0.12 1.02 0.32
77 INT261239 Binding of XDH 10 0.34 3.16 0.31
78 INT183814 Transcription of HPRT1 6 0.69 1.04 0.29
79 INT194520 Gene_expression of Uox 8 0.60 3.72 0.25
80 INT354743 Gene_expression of NT5C 1 0.20 1.72 0.25
81 INT88725 Regulation of HPRT1 5 0.62 1.28 0.24
82 INT88721 Positive_regulation of Gene_expression of HPRT1 7 0.49 2.16 0.21
83 INT294138 Positive_regulation of Localization of NT5E 1 0.14 0.41 0.21
84 INT294141 Regulation of Localization of NT5E 1 0.12 0.42 0.21
85 INT185899 Phosphorylation of HPRT1 1 0.68 0.66 0.21
86 INT311146 Protein_catabolism of APRT 1 0.01 0.39 0.2
87 INT44173 Regulation of GDA 1 0.44 0 0.19
88 INT58908 Positive_regulation of Negative_regulation of AMPD1 2 0.44 0.86 0.17
89 INT267995 Negative_regulation of Negative_regulation of XDH 2 0.30 0.77 0.15
90 INT223026 Regulation of XDH 2 0.32 2.38 0.15
91 INT7632 Protein_catabolism of AMPD1 1 0.70 0.56 0.15
92 INT310770 Positive_regulation of Transcription of HPRT1 1 0.49 0.48 0.14
93 INT194518 Binding of Uox 1 0.32 0.73 0.12
94 INT330011 Positive_regulation of Gene_expression of APRT 1 0.02 0 0.12
95 INT181919 Protein_catabolism of CAT 1 0.15 0.54 0.12
96 INT258071 Positive_regulation of Negative_regulation of APRT 1 0.02 1.19 0.11
97 INT187490 Regulation of ATIC 1 0.04 0 0.11
98 INT263205 Negative_regulation of Gene_expression of XDH 2 0.41 0.63 0.1
99 INT320095 Negative_regulation of Binding of XDH 1 0.16 0.46 0.1
100 INT323226 Negative_regulation of Localization of ADA 1 0.35 3.05 0.1
101 INT110170 Positive_regulation of Positive_regulation of ADA 1 0.49 0.46 0.1
102 INT110568 Positive_regulation of Gene_expression of XDH 7 0.49 5.14 0.09
103 INT266463 Positive_regulation of Positive_regulation of CAT 2 0.49 1.85 0.09
104 INT88724 Regulation of Gene_expression of HPRT1 2 0.27 1.04 0.09
105 INT187493 Binding of ATIC 1 0.04 0.07 0.08
106 INT31988 Binding of GDA 1 0.36 0 0.08
107 INT354744 Binding of NT5C 1 0.10 0.29 0.08
108 INT212593 Negative_regulation of IMPDH1 4 0.10 3.01 0.07
109 INT212587 Phosphorylation of IMPDH1 1 0.06 0.87 0.07
110 INT267994 Positive_regulation of Negative_regulation of XDH 1 0.33 0.37 0.07
111 INT16298 Binding of AMPD1 1 0.04 0.45 0.07
112 INT212597 Positive_regulation of Phosphorylation of IMPDH1 1 0.04 0.87 0.07
113 INT273506 Gene_expression of IMPDH1 5 0.18 0.45 0.06
114 INT218301 Binding of HPRT1 2 0.36 0.27 0.04
115 INT267997 Positive_regulation of Positive_regulation of XDH 1 0.35 0.83 0.03
116 INT232066 Binding of PNP 3 0.13 0.28 0
117 INT110570 Regulation of Gene_expression of XDH 3 0.32 1.36 0
118 INT232073 Regulation of PNP 2 0.12 0.33 0
119 INT174238 Positive_regulation of Gene_expression of PNP 2 0.16 0.69 0
120 INT164834 Regulation of AMPD1 1 0.03 0 0
121 INT194522 Positive_regulation of Uox 1 0.42 0.84 0
122 INT185335 Negative_regulation of Positive_regulation of AMPD1 1 0.27 0.1 0
123 INT110572 Transcription of XDH 1 0.52 0.15 0
124 INT285458 Negative_regulation of Gene_expression of PNP 1 0.11 0 0
125 INT47069 Localization of AMPD1 1 0.75 0.84 0
126 INT107418 Negative_regulation of Regulation of CAT 1 0.31 0 0
127 INT285456 Positive_regulation of PNP 1 0.13 0.08 0
128 INT194519 Regulation of Uox 1 0.24 0.34 0
129 INT285457 Localization of PNP 1 0.21 0 0
130 INT110571 Positive_regulation of Transcription of XDH 1 0.45 0 0
131 INT212590 Negative_regulation of Negative_regulation of IMPDH1 1 0.04 1.42 0
132 INT351508 Localization of HPRT1 1 0.41 0.1 0
133 INT194523 Localization of Uox 1 0.30 0.42 0
134 INT223030 Positive_regulation of Negative_regulation of HPRT1 1 0.46 0.69 0
135 INT329193 Regulation of Binding of NT5E 1 0.07 0.67 0
136 INT311147 Positive_regulation of Protein_catabolism of APRT 1 0.01 0.07 0
137 INT185336 Positive_regulation of Positive_regulation of AMPD1 1 0.31 0.1 0
138 INT223031 Negative_regulation of Gene_expression of HPRT1 1 0.43 0.13 0
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