GO:0006164

From wiki-pain
Jump to: navigation, search
Name purine nucleotide biosynthetic process
Categary Process
Go Slim No
Go Link GO:0006164
Unique Molecular Interactions 107
Total Molecular Interactions 141
Total Single Events 979
Pain Genes Associated 16

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for purine nucleotide biosynthetic process. They are ordered first by their pain relevance and then by number of times they were reported for purine nucleotide biosynthetic process. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT213973 Binding of Pax3 and Mthfd1 1 0.00 0.16 1.99
2 INT213968 Binding of Calca and Mthfd1 1 0.05 0.16 1.99
3 INT283426 Binding of Lcn2 and Nt5e 1 0.08 5.8 1.24
4 INT213972 Calca Regulation of Mthfd1 1 0.05 0.19 0.8
5 INT287132 Binding of NT5E and Comt 1 0.03 0.11 0.73
6 INT187522 ATIC Negative_regulation of Gene_expression of Nos2 1 0.02 1.46 0.7
7 INT213971 Mthfd1 Positive_regulation of Gene_expression of Pax3 1 0.00 0.14 0.68
8 INT127778 Mthfd1 Regulation of Positive_regulation of Mthfr 1 0.01 0.71 0.62
9 INT184243 Mthfd1 Negative_regulation of Gene_expression of Il4 1 0.02 0.88 0.56
10 INT184242 Mthfd1 Negative_regulation of Gene_expression of Csf2 1 0.03 0.87 0.56
11 INT239500 Binding of Aes and Atic 1 0.20 0.4 0.56
12 INT184244 Mthfd1 Negative_regulation of Gene_expression of TNF 1 0.01 0.88 0.56
13 INT311256 Nt5e Positive_regulation of Positive_regulation of Adora1 1 0.49 0.19 0.54
14 INT353631 Oas1a Positive_regulation of Klkb1 1 0.00 0 0.44
15 INT187519 ATIC Negative_regulation of Gene_expression of Ros1 1 0.00 1.48 0.39
16 INT204793 T Positive_regulation of Mthfd1 1 0.00 1.32 0.39
17 INT187521 ATIC Positive_regulation of Prkag1 1 0.01 1.07 0.37
18 INT252292 CCL21 Regulation of Binding of Mthfd1 1 0.03 0.41 0.33
19 INT135891 S1pr1 Regulation of Prps1 1 0.01 0.15 0.33
20 INT350701 Mthfd1 Regulation of Gene_expression of Cd4 1 0.03 1.46 0.33
21 INT276605 Tlr4 Positive_regulation of Gene_expression of Mthfd1 1 0.06 0.37 0.31
22 INT276602 Paf Positive_regulation of Gene_expression of Mthfd1 1 0.13 0.37 0.31
23 INT187518 Positive_regulation of ATIC Positive_regulation of Prkag1 1 0.01 0.99 0.25
24 INT311989 Binding of Chuk and Mthfd1 1 0.05 0.56 0.24
25 INT252340 Binding of Cd70 and Mthfd1 1 0.03 1.05 0.24
26 INT287131 Negative_regulation of Binding of NT5E and Comt 1 0.03 0.06 0.23
27 INT343911 Mthfd1 Positive_regulation of Gene_expression of IL12A 1 0.00 0.41 0.23
28 INT302712 Binding of Hprt and Hrh1 1 0.25 1.07 0.2
29 INT188698 Hand1 Positive_regulation of Localization of Mthfd1 1 0.06 0.71 0.2
30 INT283429 Nt5e Regulation of Gene_expression of Cxcr1 1 0.00 0.22 0.2
31 INT302295 PPARA Regulation of OAS2 1 0.01 0.72 0.17
32 INT213974 Vip Positive_regulation of Localization of Mthfd1 1 0.08 0.41 0.17
33 INT204790 Binding of Lat2 and Mthfd1 1 0.05 0.85 0.16
34 INT283428 Negative_regulation of Binding of Lcn2 and Nt5e 1 0.06 1.09 0.15
35 INT311255 Binding of Gpi1 and Nt5e 1 0.05 0.16 0.13
36 INT293696 Mthfd1 Positive_regulation of Akt1 1 0.05 0.08 0.13
37 INT271478 Tacr1 Regulation of Binding of Mthfd1 1 0.09 0.48 0.13
38 INT289407 Mthfd1 Negative_regulation of Cd55 1 0.01 0.6 0.12
39 INT188594 Binding of Mthfd1 and Radil 1 0.01 0.25 0.12
40 INT289404 Mthfd1 Positive_regulation of Hc 1 0.04 0.58 0.12
41 INT287130 Positive_regulation of Binding of NT5E and Comt 1 0.04 0 0.12
42 INT289405 Mthfd1 Positive_regulation of C3ar1 1 0.00 0.53 0.11
43 INT284552 Binding of Cd8a and Mthfd1 2 0.03 1.32 0.1
44 INT62775 Regulation of Binding of NT5E and OPRK1 1 0.03 0 0.1
45 INT305534 Binding of HPRT1 and Tg(CAG-EGFP)D4Nagy 1 0.03 0.7 0.1
46 INT62776 Binding of NT5E and OPRK1 1 0.02 0 0.1
47 INT305535 Binding of HPRT1 and Runx1 1 0.41 0.7 0.1
48 INT283427 Lcn2 Positive_regulation of Nt5e 1 0.08 0.21 0.09
49 INT252344 Binding of Cd40 and Mthfd1 2 0.16 0.34 0.08
50 INT297317 Positive_regulation of Mthfd1 Positive_regulation of Gene_expression of Il18 1 0.07 0.79 0.08
51 INT297309 Positive_regulation of Mthfd1 Positive_regulation of Gene_expression of Ifng 1 0.07 0.79 0.08
52 INT311988 Il4 Positive_regulation of Mthfd1 1 0.08 0.28 0.08
53 INT311986 Csf2 Positive_regulation of Mthfd1 1 0.03 0.28 0.08
54 INT184113 Socs1 Negative_regulation of Mthfd1 1 0.08 0.5 0.08
55 INT184121 Socs1 Regulation of Mthfd1 1 0.05 0.44 0.07
56 INT283425 Lcn2 Positive_regulation of Gene_expression of Nt5e 1 0.07 0.13 0.07
57 INT283433 Nt5e Positive_regulation of Localization of IL8 1 0.01 0.21 0.07
58 INT284565 Gopc Positive_regulation of Mthfd1 1 0.11 0.22 0.05
59 INT284564 Binding of Itgax and Mthfd1 1 0.08 0.09 0.05
60 INT329226 Negative_regulation of ATIC Positive_regulation of Psmd9 1 0.01 0.58 0.04
61 INT253413 ATIC Positive_regulation of Gene_expression of Prkaa2 1 0.02 0 0.04
62 INT329229 ATIC Positive_regulation of Tpt1 1 0.01 0.58 0.04
63 INT329230 Negative_regulation of ATIC Positive_regulation of Trp53 1 0.00 0.58 0.04
64 INT253417 ATIC Positive_regulation of Prkaa2 1 0.02 0.31 0.04
65 INT329231 ATIC Positive_regulation of Psmd9 1 0.01 0.58 0.04
66 INT329228 ATIC Positive_regulation of Trp53 1 0.01 0.58 0.04
67 INT314967 Binding of Cd4 and Mthfd1 1 0.09 0.11 0.04
68 INT329227 Negative_regulation of ATIC Positive_regulation of Tpt1 1 0.01 0.58 0.04
69 INT187520 ATIC Positive_regulation of Phosphorylation of Prkag1 1 0.01 0 0.03
70 INT253415 ATIC Regulation of Phosphorylation of Prkaa2 1 0.03 0 0.03
71 INT253418 ATIC Regulation of Prkaa2 1 0.02 0 0.03
72 INT252346 Binding of Apcs and Mthfd1 1 0.02 0.13 0.03
73 INT324798 Hmgb1 Positive_regulation of Positive_regulation of Mthfd1 1 0.04 0.16 0.03
74 INT311870 Positive_regulation of Binding of Cd8a and Mthfd1 1 0.00 0.32 0.03
75 INT241459 Gart Positive_regulation of Racgap1 1 0.01 0 0.03
76 INT253416 ATIC Negative_regulation of Phosphorylation of Eif4ebp1 1 0.00 0 0.03
77 INT253411 ATIC Negative_regulation of Eif4ebp1 1 0.00 0 0.03
78 INT253412 ATIC Negative_regulation of Rps6kb1 1 0.02 0 0.03
79 INT252339 Binding of Cd40 and Positive_regulation of Mthfd1 1 0.04 0.19 0
80 INT218308 Binding of HPRT1 and Grb10 1 0.26 0.07 0
81 INT189108 Mthfd1 Positive_regulation of H2 1 0.00 0.17 0
82 INT318544 Paics Regulation of Ecm1 1 0.00 1.43 0
83 INT143067 Mthfd1 Positive_regulation of Serpine1 1 0.00 0 0
84 INT189106 Mthfd1 Positive_regulation of Gene_expression of H2 1 0.00 0.17 0
85 INT252331 Binding of Cd40lg and Mthfd1 1 0.03 0.1 0
86 INT143066 Mthfd1 Regulation of Gene_expression of Plau 1 0.00 0 0
87 INT318103 Binding of UBC and Hprt 1 0.10 0.52 0
88 INT229884 Gart Regulation of AKT1 1 0.02 0.4 0
89 INT189112 Tap1 Positive_regulation of Gene_expression of Mthfd1 1 0.07 0.3 0
90 INT315941 Binding of Tlr4 and Mthfd1 1 0.05 0 0
91 INT252337 Mthfd1 Positive_regulation of Gene_expression of Cd80 1 0.04 0.1 0
92 INT284556 Tspan7 Positive_regulation of Mthfd1 1 0.00 1.66 0
93 INT355663 Binding of CA5P and OAS1 1 0.00 0.47 0
94 INT339288 Binding of Hprt1 and Il1 1 0.09 0.05 0
95 INT228285 Binding of Ptprc and Nt5e 1 0.06 0.25 0
96 INT143065 Mthfd1 Positive_regulation of Gene_expression of Serpine1 1 0.00 0 0
97 INT286884 Binding of Gopc and Mthfd1 1 0.02 0 0
98 INT293694 Binding of Ccl21a and Mthfd1 1 0.01 0 0
99 INT273495 GBP4 Negative_regulation of IMPDH1 1 0.03 0.2 0
100 INT314969 Binding of Lbr and Mthfd1 1 0.01 0 0
101 INT253410 ATIC Regulation of Lep 1 0.03 0.7 0
102 INT252333 Mthfd1 Positive_regulation of Gene_expression of Cd86 1 0.04 0.1 0
103 INT189114 Mtap1a Positive_regulation of Gene_expression of Mthfd1 1 0.01 0.3 0
104 INT284566 Tlr3 Positive_regulation of Mthfd1 1 0.17 2.43 0
105 INT228286 Binding of Cd14 and Nt5e 1 0.20 0.25 0
106 INT318100 Binding of Hprt and Ppia 1 0.32 0.52 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for purine nucleotide biosynthetic process. They are ordered first by their pain relevance and then by number of times they were reported in purine nucleotide biosynthetic process. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT21900 Gene_expression of Mthfd1 150 0.75 69.47 27.03
2 INT73252 Positive_regulation of Mthfd1 124 0.59 59.48 18.35
3 INT58449 Binding of Mthfd1 47 0.47 22.02 10.29
4 INT145888 Negative_regulation of Mthfd1 27 0.41 8.98 5.4
5 INT19391 Gene_expression of Nt5e 44 0.72 13.99 5.14
6 INT188588 Localization of Mthfd1 20 0.49 9.19 4.37
7 INT62784 Gene_expression of NT5E 46 0.65 15.95 3.72
8 INT188590 Positive_regulation of Gene_expression of Mthfd1 23 0.49 16.56 2.84
9 INT89026 Positive_regulation of Nt5e 12 0.49 7.25 2.67
10 INT19804 Negative_regulation of Hprt 18 0.59 20.6 2.17
11 INT57115 Negative_regulation of NT5E 8 0.57 4.35 2.03
12 INT89253 Regulation of Mthfd1 14 0.23 8.1 1.94
13 INT85178 Gene_expression of OAS2 10 0.21 4.17 1.93
14 INT157816 Positive_regulation of Positive_regulation of Mthfd1 5 0.33 3.73 1.93
15 INT3496 Negative_regulation of HPRT1 7 0.58 25.05 1.92
16 INT187492 Positive_regulation of ATIC 9 0.05 1.74 1.88
17 INT187489 Localization of ATIC 1 0.07 4.03 1.81
18 INT222031 Localization of Nt5e 16 0.75 3.1 1.73
19 INT88726 Gene_expression of HPRT1 36 0.78 10.12 1.58
20 INT241733 Negative_regulation of Nt5e 4 0.40 2.84 1.58
21 INT269141 Gene_expression of Oas1a 2 0.20 0 1.48
22 INT96420 Positive_regulation of NT5E 9 0.49 3.7 1.38
23 INT155036 Localization of NT5E 6 0.73 4.1 1.35
24 INT204772 Negative_regulation of Gene_expression of Mthfd1 10 0.15 3.48 1.29
25 INT187494 Gene_expression of ATIC 6 0.06 5.45 1.27
26 INT19803 Gene_expression of Hprt 15 0.67 4.81 1.03
27 INT18925 Gene_expression of Paics 3 0.52 1.25 0.93
28 INT195946 Gene_expression of Hprt1 9 0.75 1.03 0.89
29 INT37080 Negative_regulation of OAS2 4 0.05 1.3 0.89
30 INT303636 Gene_expression of OAS1 6 0.56 2.29 0.87
31 INT283402 Binding of Nt5e 10 0.30 2.53 0.85
32 INT96480 Negative_regulation of Positive_regulation of Mthfd1 5 0.30 0.99 0.83
33 INT239499 Positive_regulation of Positive_regulation of ATIC 1 0.05 0.53 0.77
34 INT287128 Protein_catabolism of NT5E 2 0.11 0.64 0.76
35 INT57008 Positive_regulation of HPRT1 11 0.50 2.81 0.74
36 INT294133 Regulation of Gene_expression of NT5E 4 0.12 1.36 0.71
37 INT188591 Positive_regulation of Binding of Mthfd1 3 0.26 0.9 0.69
38 INT93752 Positive_regulation of OAS2 2 0.13 0.67 0.64
39 INT127776 Regulation of Mthfd1 1 0.20 0.65 0.64
40 INT247550 Positive_regulation of Gene_expression of Nt5e 5 0.56 3.21 0.61
41 INT155035 Binding of NT5E 3 0.36 1.78 0.61
42 INT100941 Positive_regulation of Gene_expression of OAS2 2 0.16 0.53 0.6
43 INT287810 Regulation of Gene_expression of Mthfd1 4 0.17 2.14 0.58
44 INT187491 Phosphorylation of ATIC 6 0.07 1.67 0.49
45 INT168045 Negative_regulation of ATIC 3 0.10 1.2 0.48
46 INT158745 Regulation of Paics 1 0.24 0.58 0.48
47 INT213967 Positive_regulation of Localization of Mthfd1 4 0.30 2.52 0.46
48 INT251661 Phosphorylation of NT5E 2 0.21 1.59 0.46
49 INT96419 Positive_regulation of Gene_expression of NT5E 3 0.49 1.46 0.41
50 INT209498 Negative_regulation of Negative_regulation of Mthfd1 1 0.09 0 0.4
51 INT135888 Gene_expression of Prps1 1 0.03 0.21 0.34
52 INT287129 Regulation of NT5E 3 0.12 1.02 0.32
53 INT280121 Negative_regulation of Binding of Mthfd1 2 0.41 0.38 0.3
54 INT183814 Transcription of HPRT1 6 0.69 1.04 0.29
55 INT136760 Regulation of OAS2 1 0.01 0.21 0.27
56 INT49311 Binding of Hprt 3 0.26 0.95 0.26
57 INT88725 Regulation of HPRT1 5 0.62 1.28 0.24
58 INT88721 Positive_regulation of Gene_expression of HPRT1 7 0.49 2.16 0.21
59 INT283403 Phosphorylation of Nt5e 2 0.67 0.23 0.21
60 INT294138 Positive_regulation of Localization of NT5E 1 0.14 0.41 0.21
61 INT294141 Regulation of Localization of NT5E 1 0.12 0.42 0.21
62 INT185899 Phosphorylation of HPRT1 1 0.68 0.66 0.21
63 INT283404 Positive_regulation of Phosphorylation of Nt5e 1 0.07 0.23 0.21
64 INT247566 Transcription of Nt5e 3 0.17 1.73 0.19
65 INT293693 Phosphorylation of Mthfd1 1 0.34 0.18 0.18
66 INT41497 Positive_regulation of Hprt1 2 0.49 0.25 0.16
67 INT110564 Transcription of Hprt 5 0.37 0.82 0.15
68 INT20012 Positive_regulation of OAS1 3 0.45 1.14 0.15
69 INT310770 Positive_regulation of Transcription of HPRT1 1 0.49 0.48 0.14
70 INT289385 Negative_regulation of Localization of Mthfd1 1 0.03 0.6 0.12
71 INT187490 Regulation of ATIC 1 0.04 0 0.11
72 INT190499 Regulation of OAS1 2 0.04 0.99 0.1
73 INT350591 Positive_regulation of Gart 1 0.11 0.96 0.1
74 INT88724 Regulation of Gene_expression of HPRT1 2 0.27 1.04 0.09
75 INT296642 Localization of Hprt1 1 0.68 0.18 0.09
76 INT187493 Binding of ATIC 1 0.04 0.07 0.08
77 INT247554 Negative_regulation of Negative_regulation of Nt5e 1 0.10 1.85 0.08
78 INT212593 Negative_regulation of IMPDH1 4 0.10 3.01 0.07
79 INT212587 Phosphorylation of IMPDH1 1 0.06 0.87 0.07
80 INT247552 Regulation of Nt5e 1 0.05 2.07 0.07
81 INT212597 Positive_regulation of Phosphorylation of IMPDH1 1 0.04 0.87 0.07
82 INT273506 Gene_expression of IMPDH1 5 0.18 0.45 0.06
83 INT233666 Transcription of Hprt1 2 0.67 0.76 0.05
84 INT96481 Regulation of Positive_regulation of Mthfd1 2 0.02 1.3 0.04
85 INT218301 Binding of HPRT1 2 0.36 0.27 0.04
86 INT283401 Positive_regulation of Binding of Nt5e 1 0.06 0.41 0.04
87 INT172322 Negative_regulation of Gene_expression of Nt5e 1 0.41 1.03 0.04
88 INT248181 Positive_regulation of Gene_expression of Hprt1 2 0.49 0 0.03
89 INT229871 Binding of Gart 1 0.05 0.43 0.03
90 INT188589 Transcription of Mthfd1 1 0.35 0.07 0.03
91 INT195973 Regulation of Gene_expression of Hprt 1 0.52 0.1 0.03
92 INT195947 Regulation of Gene_expression of Hprt1 1 0.44 0.1 0.03
93 INT283409 Positive_regulation of Transcription of Nt5e 1 0.07 0.06 0.03
94 INT261190 Regulation of Hprt 3 0.60 0 0
95 INT212915 Positive_regulation of Hprt 2 0.29 0.3 0
96 INT311975 Regulation of Gene_expression of OAS1 1 0.11 0.08 0
97 INT93751 Negative_regulation of Positive_regulation of OAS2 1 0.11 0.05 0
98 INT283405 Positive_regulation of Localization of Nt5e 1 0.07 0 0
99 INT304450 Positive_regulation of Gene_expression of Hprt 1 0.18 0 0
100 INT110565 Negative_regulation of Gene_expression of Hprt 1 0.20 0 0
101 INT311251 Protein_catabolism of Nt5e 1 0.53 0 0
102 INT283398 Negative_regulation of Binding of Nt5e 1 0.05 0.46 0
103 INT355666 Binding of OAS1 1 0.27 0.47 0
104 INT212590 Negative_regulation of Negative_regulation of IMPDH1 1 0.04 1.42 0
105 INT351508 Localization of HPRT1 1 0.41 0.1 0
106 INT350587 Negative_regulation of Gart 1 0.09 0.67 0
107 INT223030 Positive_regulation of Negative_regulation of HPRT1 1 0.46 0.69 0
108 INT329193 Regulation of Binding of NT5E 1 0.07 0.67 0
109 INT223031 Negative_regulation of Gene_expression of HPRT1 1 0.43 0.13 0
110 INT302709 Negative_regulation of Transcription of Hprt 1 0.30 0.5 0
Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox