GO:0006171

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Name cAMP biosynthetic process
Categary Process
Go Slim No
Go Link GO:0006171
Unique Molecular Interactions 300
Total Molecular Interactions 354
Total Single Events 2590
Pain Genes Associated 23

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for cAMP biosynthetic process. They are ordered first by their pain relevance and then by number of times they were reported for cAMP biosynthetic process. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT134363 Prkcg Regulation of ADCY2 1 0.00 0.14 1.7
2 INT102447 Binding of CALCA and CALCRL 2 0.26 0.33 1.67
3 INT298458 Binding of Calcrl and Adarb1 1 0.00 0.23 1.41
4 INT34393 Oprd1 Negative_regulation of Adcy1 1 0.36 0 1.27
5 INT65203 OPRL1 Negative_regulation of ADCY1 1 0.19 0 1.19
6 INT49955 OPRM1 Positive_regulation of ADCY1 1 0.21 0.31 1.19
7 INT65204 PNOC Negative_regulation of ADCY1 1 0.07 0 1.14
8 INT222516 Binding of Calcrl and Ramp1 5 0.17 0.11 1.12
9 INT62381 ADCY10 Positive_regulation of Localization of IGHG3 1 0.04 0.36 1.11
10 INT62380 ADCY10 Positive_regulation of IGHG3 1 0.03 0.36 1.11
11 INT53052 ANTXRL Negative_regulation of Negative_regulation of ADCY1 1 0.01 0.66 0.99
12 INT239539 Binding of CXCR2 and CALCRL 1 0.00 0.38 0.98
13 INT206857 Binding of Calca and Calcrl 4 0.37 1.9 0.95
14 INT52114 Oprd1 Regulation of ADCY1 2 0.05 0.46 0.9
15 INT141965 Binding of ADM and CALCRL 5 0.33 3.6 0.89
16 INT52390 OPRD1 Regulation of ADCY1 1 0.09 0.13 0.86
17 INT114324 RAF1 Positive_regulation of Phosphorylation of ADCY6 1 0.02 0.05 0.85
18 INT114323 Binding of ADCY6 and RAF1 1 0.02 0.05 0.85
19 INT80877 Negative_regulation of PCDHB17 Negative_regulation of ADCY1 1 0.01 0.08 0.84
20 INT80878 PCDHB17 Negative_regulation of ADCY1 1 0.01 0.08 0.84
21 INT141963 Binding of CALCRL and RAMP1 2 0.43 0.81 0.78
22 INT346133 RAMP2 Regulation of ADM 1 0.13 2.06 0.78
23 INT305034 Adcy8 Regulation of Localization of Adcy1 1 0.35 1.51 0.77
24 INT305033 Adcy1 Regulation of Localization of Adcy8 1 0.35 1.51 0.77
25 INT190788 Adcy8 Positive_regulation of Adcy1 1 0.23 0.77 0.77
26 INT65593 CALCA Negative_regulation of Positive_regulation of ADCY1 1 0.23 0.07 0.76
27 INT157063 SLC12A1 Negative_regulation of CALCRL 1 0.00 0.34 0.73
28 INT239538 Binding of CXCR4 and CALCRL 1 0.00 0.35 0.71
29 INT130356 Adcy10 Negative_regulation of Positive_regulation of Crp 1 0.13 0.23 0.71
30 INT123869 Binding of GNAS and OPRK1 1 0.00 0.37 0.7
31 INT209593 Negative_regulation of Adcy1 Negative_regulation of Positive_regulation of Ltp 1 0.10 0 0.69
32 INT74599 YY1 Negative_regulation of ADCY1 2 0.36 0.31 0.67
33 INT130357 Adcy10 Regulation of Fgg 1 0.03 0.2 0.66
34 INT130354 Adcy10 Regulation of Serpine1 1 0.17 0.2 0.66
35 INT190211 Adm Regulation of MMP12 1 0.29 0 0.65
36 INT281081 Prkaca Positive_regulation of Gene_expression of Adcy1 1 0.12 0 0.63
37 INT346141 ADM Positive_regulation of Gene_expression of ICAM1 1 0.19 1.75 0.63
38 INT281092 Adcy1 Positive_regulation of Mapk1 1 0.21 0 0.63
39 INT281078 Prkacb Positive_regulation of Gene_expression of Adcy1 1 0.03 0 0.63
40 INT281076 Adcy1 Positive_regulation of Mdk 1 0.07 0 0.62
41 INT116787 CALCRL Regulation of Trpv1 1 0.01 0 0.56
42 INT210830 OPRM1 Negative_regulation of ADCY1 1 0.00 0.06 0.55
43 INT32908 Binding of ADCY1 and Drd2 1 0.00 0 0.54
44 INT64744 OR5D2P Negative_regulation of ADCY1 1 0.00 0 0.54
45 INT108441 Adm Positive_regulation of Sst 1 0.40 0 0.54
46 INT333309 Binding of Htr1b and Adcy1 1 0.01 0 0.53
47 INT346146 ADM Positive_regulation of Gene_expression of PERP 1 0.02 1.54 0.51
48 INT93265 Binding of ADCY1 and OPRL1 1 0.13 0.17 0.51
49 INT327806 Binding of ADORA1 and ADORA2A 1 0.06 0.18 0.49
50 INT88889 Binding of HSPG2 and CALCRL 1 0.00 0 0.48
51 INT141964 Binding of ADM and RAMP1 1 0.30 2.63 0.47
52 INT89647 OPRM1 Regulation of ADCY1 1 0.09 0.09 0.47
53 INT108440 Adm Regulation of Localization of Sst 1 0.41 0 0.45
54 INT258584 ADORA3 Negative_regulation of ADCY1 1 0.02 0 0.44
55 INT111275 BRI3P1 Positive_regulation of Negative_regulation of ADCY1 1 0.06 0 0.44
56 INT89649 INSRR Regulation of ADCY1 1 0.00 0.07 0.44
57 INT111274 C2 Positive_regulation of Negative_regulation of ADCY1 1 0.14 0 0.44
58 INT73832 Pld1 Positive_regulation of ADCY1 1 0.00 0.16 0.44
59 INT48038 Adm Regulation of Calca 1 0.31 0.14 0.42
60 INT91545 Binding of HTR1B and CALCRL 1 0.01 0.09 0.41
61 INT68526 Binding of ADCY1 and DIO2 1 0.01 0.07 0.41
62 INT140140 Adcy1 Regulation of Regulation of Atf6b 1 0.14 0.34 0.41
63 INT346151 Binding of ADM and GPER 1 0.01 0.99 0.41
64 INT68527 Binding of ADCY1 and OPRD1 1 0.06 0.07 0.41
65 INT105170 OPRD1 Positive_regulation of Phosphorylation of ADCY1 1 0.08 0 0.41
66 INT11425 OR2A12 Positive_regulation of Negative_regulation of ADCY1 1 0.01 0 0.4
67 INT105169 RAF1 Regulation of Positive_regulation of ADCY1 1 0.12 0 0.4
68 INT124799 PRKCA Positive_regulation of Localization of ADCY6 1 0.19 0 0.4
69 INT346148 Binding of ADM and VTN 1 0.15 0.93 0.39
70 INT346150 Binding of ADM and FN1 1 0.10 0.93 0.39
71 INT346140 Positive_regulation of Binding of ADM and MMRN1 1 0.04 0.93 0.39
72 INT346139 Binding of ADM and MMRN1 1 0.03 0.93 0.39
73 INT346135 Positive_regulation of Binding of ADM and FN1 1 0.13 0.93 0.39
74 INT75149 Binding of CALCRL and ZNF594 1 0.00 0.08 0.39
75 INT346142 Positive_regulation of Binding of ADM and VTN 1 0.20 0.93 0.39
76 INT122188 Binding of Crh and Ucn2 2 0.22 0.29 0.38
77 INT136821 Binding of CALCRL and OGFR 1 0.02 0.36 0.38
78 INT151546 Adcy1 Positive_regulation of Atf2 1 0.36 0.37 0.37
79 INT151545 Adcy1 Positive_regulation of Regulation of Fmr1 1 0.48 0.37 0.37
80 INT151549 Regulation of Adcy1 Positive_regulation of Atf2 1 0.33 0.37 0.37
81 INT122189 Binding of Crhr1 and Ucn2 2 0.08 0.27 0.36
82 INT53257 CALCRL Negative_regulation of Binding of Agt 1 0.00 0 0.36
83 INT346145 Binding of ADM and TPX2 1 0.01 1.05 0.35
84 INT241776 Binding of AVP and Positive_regulation of ADCY1 1 0.06 0.54 0.32
85 INT224461 F2RL1 Positive_regulation of CALCRL 1 0.00 0.37 0.31
86 INT119334 Binding of Calcrl and Positive_regulation of Gpr182 1 0.19 0.13 0.3
87 INT119333 Binding of Ramp2 and Positive_regulation of Gpr182 1 0.18 0.13 0.3
88 INT339001 GSX1 Positive_regulation of ADCY1 1 0.01 0 0.29
89 INT141438 Gnai2 Positive_regulation of Localization of ADCY1 1 0.01 0.43 0.29
90 INT210828 POMC Positive_regulation of ADCY1 1 0.03 0.34 0.28
91 INT265831 BGN Positive_regulation of ADCY1 1 0.01 0.41 0.27
92 INT178578 Binding of PTHLH and CALCRL 1 0.01 0.68 0.27
93 INT93952 CGA Positive_regulation of ADCY1 1 0.03 0 0.27
94 INT63102 OXT Regulation of CALCRL 1 0.01 0.25 0.27
95 INT93953 Negative_regulation of CGA Positive_regulation of ADCY1 1 0.03 0 0.27
96 INT78780 Binding of Calca and Adm 1 0.32 0.07 0.26
97 INT78781 Binding of Adm and Calca 1 0.01 0.07 0.26
98 INT223042 AR Positive_regulation of ADCY1 1 0.01 0.41 0.25
99 INT223036 SLURP1 Regulation of Positive_regulation of ADCY1 1 0.00 0.42 0.25
100 INT85012 CALCA Regulation of CALCRL 1 0.05 0 0.24
101 INT85011 ADM Regulation of CALCRL 1 0.06 0 0.24
102 INT31466 Binding of SGCG and CALCRL 1 0.02 0 0.23
103 INT346134 ADM Regulation of Gene_expression of MMRN1 1 0.04 1.29 0.23
104 INT34499 ADRB3 Positive_regulation of ADCY1 1 0.07 0.19 0.23
105 INT78782 Binding of Adm and Adm 1 0.01 0.07 0.23
106 INT346143 ADM Regulation of Gene_expression of TPX2 1 0.02 1.29 0.23
107 INT354544 Avp Positive_regulation of ADCY1 1 0.24 2.23 0.22
108 INT224130 Positive_regulation of Adora2a Positive_regulation of ADCY1 1 0.01 0.11 0.22
109 INT196823 Adcy5 Positive_regulation of Prkaca 1 0.13 0 0.22
110 INT194404 Binding of RAMP2 and DCLK3 1 0.07 0 0.22
111 INT7332 CALM3 Positive_regulation of ADCY1 1 0.46 0.13 0.21
112 INT318357 Binding of Pmp2 and Adcy3 1 0.06 0.26 0.2
113 INT224133 Negative_regulation of Adora2b Positive_regulation of ADCY1 1 0.01 0.1 0.2
114 INT318356 Positive_regulation of Binding of Slc10a7 and Adcy3 1 0.17 0.26 0.2
115 INT318358 Positive_regulation of Binding of Pmp2 and Adcy3 1 0.08 0.26 0.2
116 INT224134 Adora2b Positive_regulation of ADCY1 1 0.01 0.1 0.2
117 INT318359 Binding of Slc10a7 and Adcy3 1 0.12 0.26 0.2
118 INT196822 Negative_regulation of Adcy5 Positive_regulation of Pde1a 1 0.01 0 0.19
119 INT196815 Adcy5 Positive_regulation of Pde1a 1 0.01 0 0.19
120 INT216841 TCIRG1 Negative_regulation of ADCY1 1 0.01 0.35 0.18
121 INT132264 Binding of SGCG and Calcrl 1 0.02 0.25 0.18
122 INT216842 ATP6V0A1 Negative_regulation of ADCY1 1 0.01 0.35 0.18
123 INT172254 Binding of ADM and TAS2R14 1 0.02 0 0.17
124 INT172251 CALCRL Positive_regulation of Gene_expression of RAMP1 1 0.04 0.07 0.17
125 INT74600 Negative_regulation of YY1 Negative_regulation of ADCY1 1 0.36 0.25 0.17
126 INT294110 Binding of CALCRL and GOPC 1 0.00 0 0.17
127 INT172232 CALCRL Positive_regulation of Gene_expression of NRP1 1 0.02 0.07 0.17
128 INT148563 Ngf Positive_regulation of GNAS 1 0.06 0.07 0.16
129 INT341815 Binding of ADORA2A and Aia1 1 0.00 1.29 0.15
130 INT261521 Binding of ADCY1 and GLUL 1 0.01 0.09 0.15
131 INT241772 AVP Positive_regulation of ADCY1 1 0.09 1.08 0.15
132 INT77122 WDTC1 Positive_regulation of Negative_regulation of ADCY1 1 0.06 0.39 0.15
133 INT294107 Binding of DMRT1 and CALCRL 1 0.00 0 0.15
134 INT172245 Binding of ADM and NCOR2 1 0.01 0 0.15
135 INT172236 Binding of ADM and APLNR 1 0.06 0 0.14
136 INT105913 Adm Negative_regulation of Adm 1 0.01 0 0.14
137 INT196811 Binding of Pde1a and Adcy5 1 0.01 0 0.14
138 INT13014 Avp Positive_regulation of Adcy5 1 0.00 0.07 0.13
139 INT72029 Binding of ADM and IAPP 1 0.12 0.26 0.13
140 INT61998 GNPTAB Positive_regulation of ADCY1 1 0.03 0 0.13
141 INT222465 Binding of Calcrl and Rxfp2 1 0.02 0 0.12
142 INT52711 BSG Regulation of ADCY1 1 0.01 0.1 0.12
143 INT122192 Binding of Crhr2 and Ucn2 1 0.02 0.23 0.11
144 INT141426 ANTXRL Negative_regulation of ADCY1 1 0.00 0.41 0.11
145 INT255811 Binding of GNAS and MAPT 1 0.00 0.67 0.11
146 INT206856 Binding of Adm and Calcrl 1 0.04 1.76 0.1
147 INT179343 Adm Positive_regulation of Pscs 1 0.33 0.51 0.1
148 INT96563 Binding of ADRA1D and UCN2 1 0.19 1.34 0.1
149 INT29223 Binding of NCOR2 and CALCRL 1 0.00 0 0.1
150 INT72302 Regulation of ADRA2C Regulation of ADCY1 1 0.02 0.14 0.09
151 INT72304 ADRA2C Regulation of ADCY1 1 0.02 0.14 0.09
152 INT346136 ADM Positive_regulation of ICAM1 1 0.20 0.92 0.08
153 INT100127 ADM Positive_regulation of PRL 1 0.28 0.51 0.08
154 INT346147 ADM Positive_regulation of Gene_expression of VCAM1 1 0.19 0.91 0.08
155 INT346149 ADM Positive_regulation of Gene_expression of SELE 1 0.22 0.85 0.07
156 INT83589 Binding of CALCRL and Trh 1 0.01 0.18 0.07
157 INT336993 Binding of PDIA3 and CALCRL 1 0.00 0 0.06
158 INT116388 Binding of Adm and Cpox 1 0.14 0.2 0.05
159 INT206897 Binding of HTR1A and Adm 1 0.02 0.87 0.05
160 INT207700 ADM Regulation of MSMB 1 0.18 0.69 0.04
161 INT323623 Binding of Adm and Edn1 1 0.04 0.77 0.03
162 INT289764 Pgf Regulation of Adcy3 1 0.12 0 0.03
163 INT289761 Adcy1 Regulation of Adcy3 1 0.09 0 0.03
164 INT264801 Binding of Crhr2 and UCN2 1 0.00 0 0.03
165 INT329340 UCN2 Positive_regulation of SOD1 1 0.02 1.12 0
166 INT261036 Adm Regulation of Gmcl1 1 0.04 0.4 0
167 INT249538 Binding of BDNF and GNAS 1 0.08 0 0
168 INT179302 Gene_expression of GNAS Negative_regulation of CA2 1 0.01 0 0
169 INT344893 Binding of ADCY1 and Ptger4 1 0.00 0 0
170 INT222502 Binding of Crhr1 and Ucn2 1 0.01 0.05 0
171 INT329341 UCN2 Positive_regulation of THAS 1 0.00 1.12 0
172 INT225085 Binding of ADM and Negative_regulation of LEP 1 0.16 1.04 0
173 INT270778 Binding of TNFSF11 and CALCRL 1 0.00 0.44 0
174 INT336989 Binding of GNAI1 and CALCRL 1 0.00 0 0
175 INT261034 Adm Positive_regulation of Gmcl1 1 0.03 0.4 0
176 INT339817 Binding of SRP72 and UCN2 1 0.12 0.08 0
177 INT277897 EGF Positive_regulation of CALCRL 1 0.00 0.77 0
178 INT206899 ESR1 Negative_regulation of Gene_expression of Calcrl 1 0.07 0.15 0
179 INT109249 Calcrl Regulation of Ramp1 1 0.28 0.22 0
180 INT337011 Binding of CALCRL and Agtrap 1 0.00 0 0
181 INT303004 Adm Positive_regulation of Gsk3b 1 0.04 0.97 0
182 INT344892 Binding of ADCY1 and Ptger2 1 0.01 0 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for cAMP biosynthetic process. They are ordered first by their pain relevance and then by number of times they were reported in cAMP biosynthetic process. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT6490 Negative_regulation of ADCY1 145 0.58 26.25 70.96
2 INT1599 Positive_regulation of ADCY1 146 0.67 30.05 64.9
3 INT106720 Positive_regulation of Adcy1 30 0.50 22.05 22.68
4 INT22068 Binding of CALCRL 53 0.41 6.14 17.32
5 INT12617 Regulation of ADCY1 41 0.61 7.38 15.94
6 INT42810 Gene_expression of CALCRL 53 0.77 10.87 15.42
7 INT130424 Negative_regulation of Adcy1 19 0.58 16.31 13.6
8 INT63104 Negative_regulation of CALCRL 29 0.37 13.62 12.42
9 INT11429 Gene_expression of ADCY1 26 0.74 5.89 11.93
10 INT40486 Positive_regulation of Positive_regulation of ADCY1 20 0.48 4.29 11.33
11 INT5464 Regulation of CALCRL 24 0.16 4.2 11.19
12 INT85015 Gene_expression of ADM 29 0.73 30.75 10.21
13 INT12620 Negative_regulation of Negative_regulation of ADCY1 16 0.44 2.98 10.1
14 INT5465 Positive_regulation of CALCRL 25 0.49 7.24 9.8
15 INT55038 Gene_expression of Adcy8 10 0.77 28.79 9.8
16 INT106719 Gene_expression of Adcy1 18 0.77 12.18 8.42
17 INT54681 Negative_regulation of Positive_regulation of ADCY1 16 0.38 2.7 8.14
18 INT11568 Gene_expression of ADORA2A 14 0.73 1.51 7.79
19 INT55034 Positive_regulation of Adm 27 0.61 14.1 6.13
20 INT55037 Positive_regulation of Adcy8 7 0.61 5.92 5.36
21 INT80881 Phosphorylation of ADCY1 7 0.69 1.22 5.29
22 INT109246 Gene_expression of Calcrl 16 0.75 4.71 5.19
23 INT78393 Gene_expression of Adm 16 0.78 8.4 4.92
24 INT14574 Positive_regulation of Negative_regulation of ADCY1 9 0.66 2.45 4.39
25 INT70756 Gene_expression of Adm 28 0.77 13.33 4.22
26 INT106721 Regulation of Adcy1 6 0.45 2.32 4.17
27 INT32933 Gene_expression of GNAS 57 0.32 10.58 4.03
28 INT119330 Binding of Calcrl 8 0.37 1.96 3.85
29 INT102452 Gene_expression of RAMP2 6 0.69 7.11 3.77
30 INT87408 Negative_regulation of ADCY2 3 0.01 0.1 3.68
31 INT87281 Localization of ADCY1 7 0.64 1.84 3.42
32 INT102451 Localization of CALCRL 9 0.69 0 3.25
33 INT128138 Positive_regulation of Positive_regulation of Adcy1 5 0.45 2.67 3.25
34 INT13179 Regulation of Positive_regulation of ADCY1 5 0.34 0.89 3.08
35 INT59309 Negative_regulation of Gene_expression of ADCY1 3 0.42 1.04 2.98
36 INT69641 Positive_regulation of ADCY2 5 0.32 0.18 2.87
37 INT30815 Binding of ADCY1 7 0.36 0.21 2.79
38 INT76875 Positive_regulation of Adm 12 0.58 3.36 2.72
39 INT80884 Positive_regulation of Phosphorylation of ADCY1 4 0.43 0.24 2.64
40 INT11426 Positive_regulation of Gene_expression of ADCY1 5 0.29 0.68 2.63
41 INT305030 Localization of Adcy8 2 0.75 8.18 2.63
42 INT55036 Regulation of Adcy8 3 0.44 0.85 2.56
43 INT77213 Transcription of ADORA2A 1 0.69 0 2.55
44 INT55039 Positive_regulation of Gene_expression of Adcy8 3 0.69 6.64 2.39
45 INT250727 Negative_regulation of ADM 3 0.38 8.32 2.26
46 INT179311 Transcription of GNAS 2 0.10 0.67 2.08
47 INT108903 Negative_regulation of GNAS 7 0.57 1.58 2.04
48 INT190783 Binding of Adcy1 3 0.35 1.35 2.03
49 INT141968 Positive_regulation of ADM 12 0.65 11.19 2
50 INT190782 Negative_regulation of Adcy8 3 0.58 4.37 1.84
51 INT94163 Negative_regulation of UCN2 11 0.57 6.86 1.75
52 INT102449 Binding of ADM 12 0.33 5.85 1.73
53 INT62972 Gene_expression of Adcy5 3 0.67 0.23 1.72
54 INT87289 Positive_regulation of Localization of ADCY1 3 0.43 0.36 1.65
55 INT289739 Positive_regulation of Adcy3 3 0.28 0.64 1.63
56 INT305029 Localization of Adcy1 2 0.70 5.94 1.63
57 INT80890 Negative_regulation of Phosphorylation of ADCY1 2 0.36 0.24 1.57
58 INT72310 Regulation of Regulation of ADCY1 6 0.24 1.24 1.55
59 INT13013 Positive_regulation of Adcy5 4 0.67 0.3 1.49
60 INT121347 Binding of GNAS 8 0.13 3.99 1.47
61 INT118988 Negative_regulation of Adm 3 0.10 1.05 1.41
62 INT162308 Phosphorylation of GNAS 3 0.01 1.71 1.4
63 INT148932 Localization of Calcrl 3 0.79 1.65 1.35
64 INT102228 Localization of Adm 9 0.69 1.58 1.34
65 INT148562 Positive_regulation of GNAS 13 0.16 5.31 1.32
66 INT169743 Regulation of Positive_regulation of Adm 1 0.37 0.38 1.32
67 INT252389 Negative_regulation of Gene_expression of ADM 2 0.38 4.78 1.3
68 INT106834 Negative_regulation of Negative_regulation of CALCRL 1 0.01 0.16 1.3
69 INT61429 Gene_expression of Adcy5 6 0.60 1.49 1.27
70 INT80887 Negative_regulation of Regulation of ADCY1 3 0.35 0.1 1.26
71 INT48037 Regulation of Adm 8 0.44 3.96 1.24
72 INT97474 Positive_regulation of UCN2 6 0.67 1.85 1.23
73 INT141969 Positive_regulation of Gene_expression of ADM 4 0.57 4.07 1.2
74 INT94162 Binding of UCN2 3 0.36 1.8 1.18
75 INT157064 Negative_regulation of Regulation of CALCRL 2 0.02 0.33 1.18
76 INT75891 Regulation of ADCY2 3 0.06 0.06 1.17
77 INT81757 Regulation of Gene_expression of Adm 6 0.44 2.86 1.16
78 INT119124 Positive_regulation of ADORA2A 4 0.35 0.96 1.14
79 INT295165 Negative_regulation of Adcy1 1 0.09 1.3 1.13
80 INT150838 Positive_regulation of Gene_expression of Adm 4 0.06 1.98 1.11
81 INT216849 Binding of ADORA2A 2 0.05 0 1.11
82 INT114326 Phosphorylation of ADCY6 2 0.70 0.05 1.11
83 INT124810 Gene_expression of ADCY6 6 0.65 0 1.06
84 INT144767 Gene_expression of UCN2 5 0.65 1.78 1.04
85 INT108347 Regulation of Adm 5 0.26 2.55 1.04
86 INT72868 Transcription of ADCY1 4 0.57 0.69 1.04
87 INT196743 Binding of Adcy5 1 0.25 0 1.04
88 INT51994 Positive_regulation of Gene_expression of CALCRL 4 0.03 0.13 1.02
89 INT86800 Positive_regulation of Binding of CALCRL 3 0.37 0 1.01
90 INT119125 Regulation of ADORA2A 2 0.31 0 1.01
91 INT190776 Negative_regulation of Gene_expression of Adcy1 3 0.43 0.96 0.93
92 INT225094 Localization of ADM 5 0.63 3.89 0.91
93 INT77215 Localization of ADORA2A 2 0.77 0 0.91
94 INT80871 Negative_regulation of Binding of ADCY1 1 0.03 0.1 0.91
95 INT118987 Localization of Adm 4 0.50 0.34 0.84
96 INT163889 Regulation of Gene_expression of Calcrl 3 0.21 1 0.84
97 INT151943 Negative_regulation of Positive_regulation of UCN2 2 0.42 0.55 0.82
98 INT305028 Positive_regulation of Positive_regulation of Adcy8 1 0.44 1.56 0.82
99 INT196762 Negative_regulation of Adcy5 5 0.39 1.49 0.8
100 INT3211 Positive_regulation of Calcrl 3 0.23 0.81 0.8
101 INT124814 Localization of ADCY6 1 0.65 0 0.78
102 INT61427 Gene_expression of Adcy3 6 0.55 0.53 0.77
103 INT119331 Gene_expression of Ramp2 2 0.60 0.19 0.75
104 INT196734 Positive_regulation of Adcy5 1 0.35 0 0.75
105 INT62973 Positive_regulation of Gene_expression of Adcy5 1 0.05 0.16 0.74
106 INT124813 Negative_regulation of ADCY6 1 0.37 0 0.73
107 INT124811 Positive_regulation of Negative_regulation of ADCY6 1 0.40 0 0.73
108 INT130425 Negative_regulation of Negative_regulation of Adcy1 2 0.43 0.57 0.65
109 INT36313 Localization of ADCY10 3 0.73 1.74 0.62
110 INT116247 Positive_regulation of Localization of Adm 1 0.04 0.17 0.62
111 INT116786 Negative_regulation of Localization of CALCRL 1 0.01 0 0.61
112 INT3209 Regulation of Calcrl 3 0.26 1.31 0.6
113 INT3210 Negative_regulation of Calcrl 1 0.03 0.64 0.6
114 INT249551 Negative_regulation of Transcription of GNAS 1 0.06 0.16 0.6
115 INT127930 Gene_expression of ADCY2 6 0.11 0.1 0.59
116 INT96689 Positive_regulation of Positive_regulation of CALCRL 1 0.01 0.08 0.59
117 INT94190 Positive_regulation of ADCY10 5 0.49 3.17 0.58
118 INT346182 Positive_regulation of Gene_expression of RAMP2 1 0.14 1.51 0.58
119 INT165848 Protein_catabolism of ADCY1 1 0.25 0.28 0.57
120 INT190778 Positive_regulation of Gene_expression of Adcy1 2 0.50 1.49 0.55
121 INT62384 Negative_regulation of ADCY10 2 0.42 0.18 0.55
122 INT165845 Positive_regulation of Transcription of ADCY1 1 0.26 0.36 0.55
123 INT74101 Negative_regulation of Adm 3 0.06 1.2 0.53
124 INT116785 Regulation of Localization of CALCRL 1 0.00 0 0.53
125 INT346181 Regulation of Gene_expression of ADM 1 0.35 1.67 0.52
126 INT333289 Positive_regulation of Binding of Adcy1 1 0.28 0 0.52
127 INT235847 Transcription of Adcy1 2 0.25 0.42 0.5
128 INT119326 Positive_regulation of Ramp2 1 0.42 0.2 0.48
129 INT110905 Regulation of Negative_regulation of ADCY1 1 0.59 0 0.48
130 INT116387 Binding of Adm 6 0.47 1 0.46
131 INT53256 Negative_regulation of Binding of CALCRL 4 0.03 0.33 0.45
132 INT235845 Positive_regulation of Transcription of Adcy1 1 0.13 0.43 0.44
133 INT71561 Positive_regulation of Gene_expression of Adm 4 0.61 2.67 0.43
134 INT336707 Negative_regulation of Gene_expression of Adcy8 1 0.58 3.17 0.43
135 INT207726 Regulation of ADM 4 0.40 2.14 0.42
136 INT346192 Negative_regulation of RAMP2 1 0.12 0.92 0.42
137 INT164178 Gene_expression of ADCY10 9 0.65 2.72 0.39
138 INT346173 Negative_regulation of Positive_regulation of ADM 1 0.38 1.02 0.39
139 INT124808 Positive_regulation of Localization of ADCY6 1 0.43 0 0.38
140 INT224479 Protein_catabolism of CALCRL 1 0.01 0.62 0.37
141 INT224502 Positive_regulation of Protein_catabolism of CALCRL 1 0.00 0.62 0.37
142 INT119123 Regulation of Positive_regulation of ADORA2A 1 0.31 0 0.35
143 INT150839 Regulation of Gene_expression of Adm 1 0.04 0.89 0.35
144 INT138362 Regulation of Negative_regulation of ADCY2 1 0.01 0 0.34
145 INT336709 Negative_regulation of Localization of Adcy1 1 0.35 0.88 0.34
146 INT164337 Localization of Adcy5 1 0.38 0 0.33
147 INT124812 Positive_regulation of ADCY6 1 0.43 0 0.33
148 INT290530 Binding of Ucn2 1 0.08 0.78 0.33
149 INT243867 Regulation of Negative_regulation of CALCRL 1 0.01 0 0.33
150 INT164338 Regulation of Adcy5 1 0.14 0 0.33
151 INT109245 Positive_regulation of Gene_expression of Calcrl 3 0.67 0.89 0.3
152 INT138363 Positive_regulation of Gene_expression of ADCY2 1 0.01 0 0.3
153 INT119325 Binding of Ramp2 1 0.33 0.12 0.29
154 INT327817 Negative_regulation of ADORA2A 1 0.17 1.83 0.27
155 INT200894 Positive_regulation of Adcy1 1 0.06 0.23 0.26
156 INT289743 Regulation of Positive_regulation of Adcy3 1 0.25 0 0.25
157 INT196792 Binding of Adcy5 1 0.35 0 0.25
158 INT289745 Positive_regulation of Positive_regulation of Adcy3 1 0.28 0 0.25
159 INT102450 Positive_regulation of Binding of ADM 1 0.29 0 0.24
160 INT122601 Transcription of Adm 1 0.29 0.73 0.24
161 INT122603 Positive_regulation of Transcription of Adm 1 0.26 0.74 0.24
162 INT108902 Localization of GNAS 5 0.13 1.31 0.23
163 INT51109 Gene_expression of Adcy1 2 0.09 0.15 0.23
164 INT150837 Positive_regulation of Regulation of Adm 1 0.06 0.64 0.23
165 INT102227 Protein_catabolism of Adm 1 0.30 0 0.21
166 INT130423 Regulation of Positive_regulation of Adcy1 1 0.05 0.1 0.21
167 INT339845 Phosphorylation of UCN2 1 0.23 0.31 0.2
168 INT127931 Positive_regulation of Gene_expression of ADCY6 2 0.49 0 0.17
169 INT285210 Regulation of Adcy3 1 0.28 0.07 0.14
170 INT206888 Negative_regulation of Gene_expression of Calcrl 2 0.26 0.83 0.13
171 INT127934 Regulation of ADCY6 1 0.09 0 0.13
172 INT127929 Regulation of Gene_expression of ADCY6 1 0.21 0 0.13
173 INT102229 Regulation of Localization of Adm 1 0.08 0 0.13
174 INT127928 Regulation of Gene_expression of ADCY2 1 0.08 0 0.13
175 INT340828 Regulation of ADCY10 1 0.06 5.17 0.11
176 INT196776 Negative_regulation of Negative_regulation of Adcy5 1 0.22 0 0.11
177 INT289728 Positive_regulation of Gene_expression of Adcy3 1 0.28 0 0.1
178 INT285212 Negative_regulation of Gene_expression of Adcy3 1 0.30 0.17 0.1
179 INT222603 Negative_regulation of Gene_expression of Ramp2 1 0.09 0 0.09
180 INT252444 Positive_regulation of Binding of ADCY1 1 0.03 0 0.09
181 INT127926 Negative_regulation of Gene_expression of ADCY2 1 0.06 0 0.08
182 INT329014 Localization of UCN2 2 0.23 0.14 0.07
183 INT127924 Transcription of ADCY6 1 0.18 0 0.07
184 INT127932 Regulation of Transcription of ADCY6 1 0.09 0 0.07
185 INT261031 Positive_regulation of Positive_regulation of Adm 1 0.05 1.14 0.07
186 INT112599 Regulation of Positive_regulation of Adm 1 0.22 0 0.06
187 INT179307 Regulation of GNAS 7 0.01 1.93 0.05
188 INT289737 Transcription of Adcy3 1 0.38 0 0.05
189 INT97893 Gene_expression of Ucn2 1 0.09 0.42 0.05
190 INT289730 Negative_regulation of Transcription of Adcy1 1 0.15 0 0.05
191 INT289732 Negative_regulation of Transcription of Adcy3 1 0.24 0 0.05
192 INT196788 Positive_regulation of Binding of Adcy5 1 0.22 0 0.05
193 INT97895 Positive_regulation of Gene_expression of Ucn2 1 0.06 0.43 0.05
194 INT252388 Transcription of ADM 1 0.03 0 0.04
195 INT323621 Binding of Adm 1 0.32 1.02 0.03
196 INT222632 Gene_expression of Ucn2 1 0.13 0 0.03
197 INT177312 Negative_regulation of Gene_expression of GNAS 2 0.05 0.46 0
198 INT225092 Positive_regulation of Localization of ADM 1 0.29 0.06 0
199 INT289446 Transcription of CALCRL 1 0.01 0.1 0
200 INT255830 Positive_regulation of Localization of GNAS 1 0.01 0.28 0
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