GO:0006182

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Name cGMP biosynthetic process
Categary Process
Go Slim No
Go Link GO:0006182
Unique Molecular Interactions 378
Total Molecular Interactions 556
Total Single Events 6024
Pain Genes Associated 25

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for cGMP biosynthetic process. They are ordered first by their pain relevance and then by number of times they were reported for cGMP biosynthetic process. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT11599 Calca Positive_regulation of Npr1 5 0.19 0.3 4.8
2 INT7022 Drd1a Positive_regulation of Npr1 6 0.05 0.26 4.32
3 INT111787 Cck Regulation of Gene_expression of Npr1 1 0.22 1.68 2.57
4 INT107812 Nppa Positive_regulation of Localization of Sst 1 0.48 0.54 2.51
5 INT240131 Binding of Crp and Nppb 7 0.07 11.53 2.12
6 INT33756 Akr1d1 Positive_regulation of Npr1 3 0.01 0 2.05
7 INT21261 Penk Negative_regulation of Npr1 1 0.02 0 2
8 INT7023 Negative_regulation of Drd1a Positive_regulation of Npr1 2 0.05 0.1 1.81
9 INT68709 Positive_regulation of Crh Regulation of Npr1 1 0.03 0 1.71
10 INT68710 Crh Regulation of Npr1 1 0.03 0 1.7
11 INT96296 Oprm1 Negative_regulation of Npr1 2 0.05 0.32 1.65
12 INT144213 Nppa Positive_regulation of Localization of Calca 1 0.71 2.8 1.65
13 INT33757 Hmmr Positive_regulation of Npr1 1 0.01 0 1.59
14 INT107815 Gene_expression of Sst Positive_regulation of Localization of Nppa 1 0.52 0.27 1.57
15 INT107813 Sst Negative_regulation of Localization of Nppa 1 0.44 0.2 1.46
16 INT291583 GUCY2C Regulation of Pde5a 1 0.00 1.12 1.45
17 INT266811 Binding of HRH1 and HTR2C 1 0.23 2.06 1.4
18 INT6466 Binding of Npr1 and Oprd1 1 0.01 0 1.37
19 INT31772 Ednra Positive_regulation of Nppa 1 0.05 0.13 1.33
20 INT31771 Penk Positive_regulation of Nppa 1 0.22 0.13 1.28
21 INT31773 Pdyn Positive_regulation of Nppa 1 0.12 0.13 1.27
22 INT143620 Ltp Positive_regulation of Npr1 1 0.01 0.16 1.26
23 INT342165 Binding of Aqp1 and Nav1 1 0.25 0.57 1.25
24 INT42554 Oprl1 Regulation of Npr1 2 0.06 0 1.22
25 INT62596 Binding of Edn1 and Nppa 1 0.27 1.77 1.22
26 INT13205 Oprd1 Negative_regulation of Npr1 2 0.01 0 1.16
27 INT13204 Binding of Npr1 and Akr1d1 1 0.00 0 1.14
28 INT7024 Regulation of Drd1a Positive_regulation of Npr1 1 0.04 0.07 1.13
29 INT33142 Pck1 Positive_regulation of Npr1 4 0.01 0.5 1.02
30 INT13502 Penk Positive_regulation of Npr1 1 0.02 0.19 1.01
31 INT13503 Regulation of Penk Positive_regulation of Npr1 1 0.02 0.19 1.01
32 INT7025 Positive_regulation of Drd1a Positive_regulation of Npr1 1 0.04 0.08 1.01
33 INT60208 Binding of Htr1a and Htr2c 2 0.52 0.25 1
34 INT42555 Oprl1 Negative_regulation of Npr1 1 0.02 0 0.99
35 INT28194 Nppb Positive_regulation of CYP2B6 1 0.50 0.05 0.88
36 INT28193 Nppb Positive_regulation of Positive_regulation of RYBP 1 0.29 0.05 0.88
37 INT111790 Penk Regulation of Gene_expression of Npr1 1 0.22 0.56 0.86
38 INT41156 Sst Negative_regulation of Npr1 1 0.05 0 0.84
39 INT29781 PDYN Negative_regulation of Npr1 1 0.00 0.22 0.84
40 INT298457 Binding of Calca and Npr1 1 0.01 0.39 0.77
41 INT166902 NPPB Positive_regulation of TRPA1 1 0.78 0.76 0.77
42 INT107810 Sst Positive_regulation of Localization of Nppa 1 0.42 0.14 0.77
43 INT21260 Positive_regulation of Drd1a Positive_regulation of Npr1 1 0.05 0 0.76
44 INT147619 Npr1 Positive_regulation of Localization of Calca 1 0.03 0 0.75
45 INT57658 ASNA1 Positive_regulation of Npr1 1 0.00 0.15 0.74
46 INT169603 Nppb Regulation of Npr1 1 0.26 0.95 0.69
47 INT71988 Drd1a Regulation of Npr1 1 0.10 0 0.68
48 INT111555 Negative_regulation of Npr1 Negative_regulation of Positive_regulation of Creb1 1 0.02 0.58 0.66
49 INT6464 Sst Regulation of Negative_regulation of Npr1 1 0.01 0 0.64
50 INT6463 Oprd1 Regulation of Negative_regulation of Npr1 1 0.01 0 0.63
51 INT6465 Trh Regulation of Negative_regulation of Npr1 1 0.01 0 0.63
52 INT16412 Nppa Negative_regulation of Localization of LH 2 0.41 0.29 0.62
53 INT74395 Htr2b Negative_regulation of Pdyn 1 0.03 0 0.61
54 INT147049 CB Positive_regulation of Nppa 1 0.02 1.01 0.6
55 INT144864 Htr2b Positive_regulation of Localization of Gh1 1 0.48 0 0.58
56 INT101216 Pnoc Positive_regulation of Localization of Nppa 1 0.68 0.09 0.57
57 INT147040 Hmbs Negative_regulation of Nppa 1 0.07 0.95 0.55
58 INT107814 Nppa Positive_regulation of Positive_regulation of Sst 1 0.42 0.16 0.55
59 INT16643 Nppa Regulation of Rabep2 1 0.13 0.07 0.55
60 INT43075 Slc6a14 Regulation of Positive_regulation of Npr1 1 0.01 0 0.51
61 INT43076 Slc6a14 Regulation of Npr1 1 0.01 0 0.51
62 INT7120 Nppb Positive_regulation of Localization of Rab8a 1 0.08 0 0.51
63 INT55265 Ptgdr Negative_regulation of Npr1 1 0.01 0 0.46
64 INT16413 Nppa Regulation of Localization of LH 1 0.43 0.76 0.45
65 INT52679 Positive_regulation of Npr1 Positive_regulation of Positive_regulation of VSX1 1 0.00 0 0.45
66 INT25430 Gtf3a Regulation of Nppa 1 0.24 0.57 0.43
67 INT170157 NPPC Regulation of CSF2 1 0.12 1.36 0.42
68 INT309157 Aqp1 Positive_regulation of Bdnf 1 0.00 0.74 0.42
69 INT79486 Nppa Negative_regulation of NA 1 0.03 1.83 0.41
70 INT16411 Nppb Regulation of Localization of LH 1 0.34 0.49 0.41
71 INT131353 Binding of Npr1 and Nppb 1 0.27 1.73 0.4
72 INT131356 Binding of Nppa and Npr1 1 0.27 1.73 0.4
73 INT57649 Oprd1 Positive_regulation of Npr1 1 0.01 0.1 0.39
74 INT95999 Binding of Npr1 and Cnr1 1 0.05 0 0.39
75 INT71575 Negative_regulation of Nppb Positive_regulation of Gbf1 1 0.02 0.08 0.38
76 INT71574 Nppb Positive_regulation of Gbf1 1 0.02 0.08 0.38
77 INT16410 Nppb Negative_regulation of Localization of LH 1 0.37 0.21 0.38
78 INT169604 Nppb Positive_regulation of Npr1 2 0.52 2.52 0.37
79 INT154356 Binding of Nppc and ITS 1 0.00 0.85 0.35
80 INT32698 Nppa Regulation of Oxt 1 0.57 0.35 0.35
81 INT84085 Binding of Gucy1a2 and Nisch 1 0.00 0.22 0.35
82 INT32699 Nppa Regulation of Avp 1 0.28 0.35 0.35
83 INT240129 Binding of Nppb and Crp 1 0.21 1.02 0.32
84 INT46663 Guca2a Positive_regulation of Gucy2f 1 0.02 0 0.32
85 INT46664 GYPA Positive_regulation of Gucy2f 1 0.00 0 0.32
86 INT115261 Gene_expression of Nos2 Positive_regulation of Positive_regulation of Npr1 1 0.05 0.67 0.31
87 INT166901 NPPB Positive_regulation of Gene_expression of TRPA1 1 0.68 0.33 0.3
88 INT147041 Hmbs Negative_regulation of Negative_regulation of Nppa 1 0.05 0.51 0.3
89 INT30706 Nppa Positive_regulation of Localization of AVP 1 0.78 0.45 0.3
90 INT139778 Binding of AQP1 and GBE1 1 0.00 0.22 0.3
91 INT96436 Binding of Npr1 and Oprl1 1 0.05 0 0.29
92 INT136245 Gucy1a2 Positive_regulation of Nppa 1 0.06 0.22 0.27
93 INT208499 Positive_regulation of Nkx1-1 Positive_regulation of Npr1 1 0.00 0 0.27
94 INT149358 Binding of Oprm1 and Positive_regulation of Positive_regulation of Npr1 1 0.00 0.09 0.26
95 INT83220 Gucy1a2 Positive_regulation of Positive_regulation of Glp1r 1 0.02 0 0.26
96 INT136246 Gucy1a2 Negative_regulation of Nppa 1 0.05 0.22 0.26
97 INT20587 Nppa Positive_regulation of Gfra1 1 0.02 0.32 0.26
98 INT47012 Regulation of Pck1 Positive_regulation of Npr1 1 0.01 0 0.26
99 INT32636 Slc12a3 Regulation of Localization of Nppa 1 0.00 0.41 0.23
100 INT170158 NPPA Positive_regulation of Gene_expression of NPPB 1 0.13 0.91 0.23
101 INT58305 AQP1 Regulation of Localization of TNF 1 0.10 0.16 0.22
102 INT58303 AQP1 Regulation of Gene_expression of IL1B 1 0.10 0.16 0.22
103 INT146993 Binding of NPPA and NPPC 1 0.27 0.82 0.22
104 INT32565 Nppa Regulation of Localization of CGA 1 0.00 0.07 0.22
105 INT131355 Npr1 Regulation of Nppb 1 0.39 0.88 0.22
106 INT131354 Npr1 Regulation of Nppa 1 0.40 0.88 0.22
107 INT342163 Nkx2-1 Regulation of Gene_expression of Aqp1 1 0.06 0.51 0.2
108 INT25089 Glul Positive_regulation of Npr1 1 0.00 0 0.2
109 INT21171 Nppa Regulation of Ren 1 0.35 0.35 0.19
110 INT32700 Nppa Negative_regulation of Oxt 1 0.40 0.16 0.19
111 INT32696 Nppa Negative_regulation of Avp 1 0.45 0.16 0.19
112 INT32697 Nppa Negative_regulation of Gene_expression of Oxt 1 0.40 0.16 0.19
113 INT32494 Nppa Negative_regulation of Localization of Avp 1 0.28 1.16 0.18
114 INT154355 Binding of Nppc and Npr1 1 0.19 0.43 0.18
115 INT29959 Ahsp Positive_regulation of Npr1 1 0.00 0.18 0.17
116 INT33141 Pck1 Regulation of Npr1 1 0.00 0.17 0.16
117 INT26367 POMC Regulation of Localization of NPPA 1 0.28 0.29 0.16
118 INT310595 Ros1 Positive_regulation of Npr1 1 0.03 0.84 0.16
119 INT30705 Nppa Negative_regulation of Localization of AVP 1 0.48 0.22 0.15
120 INT251435 Gnat3 Positive_regulation of NPR1 1 0.22 0.2 0.15
121 INT7296 Binding of HCLS1 and NPPA 1 0.02 1.65 0.15
122 INT85333 Aqp1 Positive_regulation of Negative_regulation of Tgfb1 1 0.25 0.67 0.15
123 INT327829 Aqp1 Regulation of Binding of Csf2 1 0.11 1 0.14
124 INT56181 sch Regulation of Positive_regulation of Nppa 1 0.07 0.08 0.14
125 INT109082 Adra2a Regulation of Nppa 1 0.21 0.56 0.14
126 INT173725 Binding of Gucy2c and Ccl4 1 0.08 0.53 0.12
127 INT184608 APC Regulation of Gene_expression of Nppa 1 0.06 1.11 0.12
128 INT170159 Negative_regulation of NPPC Regulation of CSF2 1 0.20 0.33 0.11
129 INT71755 Nppa Regulation of Localization of Alb 1 0.25 1.29 0.11
130 INT7302 Binding of NPPA and Nppa 1 0.13 1.25 0.11
131 INT42154 NPPA Regulation of Gene_expression of TUBA4A 1 0.04 0.68 0.1
132 INT25090 Negative_regulation of Glul Positive_regulation of Npr1 1 0.00 0 0.1
133 INT43284 Binding of Npr1 and Gcg 1 0.05 0 0.1
134 INT10906 Agt Regulation of Localization of Nppb 1 0.10 0.19 0.1
135 INT5627 Tfpi Positive_regulation of Localization of Nppa 1 0.31 0.07 0.1
136 INT42153 NPPA Regulation of TUBA4A 1 0.04 0.68 0.1
137 INT164428 Gsta3 Positive_regulation of Npr1 1 0.00 0 0.1
138 INT5626 Tfpi Positive_regulation of Transcription of Nppa 1 0.31 0.07 0.1
139 INT10904 Edn1 Regulation of Localization of Nppb 1 0.22 0.54 0.1
140 INT46240 Npr1 Positive_regulation of Localization of Avp 1 0.05 0 0.09
141 INT7295 HCLS1 Positive_regulation of NPPA 1 0.02 0.44 0.09
142 INT174093 Htr2c Regulation of Gene_expression of Csf2 1 0.00 0 0.09
143 INT174070 Htr2c Positive_regulation of Itpr3 1 0.00 0 0.09
144 INT9086 Binding of Nppa and Nppb 1 0.35 0.19 0.08
145 INT208937 Nfkb1 Positive_regulation of Gene_expression of Nppa 1 0.04 0.38 0.08
146 INT25269 Hmmr Negative_regulation of Npr1 1 0.01 0.63 0.08
147 INT91097 Ptprg Positive_regulation of Npr1 1 0.00 0.62 0.08
148 INT257226 Phosphorylation of Prkacb Positive_regulation of Npr1 1 0.00 0 0.08
149 INT222489 Npr2 Positive_regulation of Pde5a 1 0.00 0.16 0.07
150 INT50079 Binding of NPPA and SLC12A1 1 0.01 0.42 0.07
151 INT51719 Nppa Regulation of Regulation of Pomc 1 0.14 0.1 0.07
152 INT146721 Nppc Positive_regulation of Positive_regulation of Oprl1 1 0.16 0.34 0.07
153 INT50078 Binding of APOE and NPPA 1 0.30 0.42 0.07
154 INT91098 Gcgr Positive_regulation of Npr1 1 0.01 0.38 0.06
155 INT16414 Nppa Regulation of Nppb 1 0.24 0.26 0.05
156 INT43283 Gcg Positive_regulation of Npr1 1 0.07 0 0.05
157 INT222512 Nppa Positive_regulation of Localization of LH 1 0.02 0 0.05
158 INT122713 Guca2b Positive_regulation of RTCA 1 0.03 0.16 0.05
159 INT208945 Nkx2-5 Positive_regulation of Gene_expression of Nppa 1 0.03 0.33 0.05
160 INT171399 Binding of Npr1 and Prkcg 1 0.00 0.23 0.04
161 INT171401 Binding of Adcyap1 and Npr1 1 0.02 0.23 0.04
162 INT239402 Binding of NPPA and ASAP1 1 0.19 1.24 0.04
163 INT158391 Oxt Positive_regulation of Localization of Nppa 2 0.27 0.64 0.03
164 INT44815 Sct Positive_regulation of Npr1 1 0.06 0 0.03
165 INT325600 Nppa Positive_regulation of Pde2a 1 0.11 0.16 0.03
166 INT325586 Nppa Positive_regulation of Prkg1 1 0.28 0.16 0.03
167 INT177671 Vmn1r51 Positive_regulation of Localization of Nppa 1 0.01 0.24 0.03
168 INT253085 NPPA Positive_regulation of INS 1 0.32 0 0
169 INT10901 Edn1 Positive_regulation of Localization of Nppb 1 0.39 0.68 0
170 INT10903 Apoa2 Positive_regulation of Nppb 1 0.08 0.17 0
171 INT233506 Tlr4 Positive_regulation of Htr2b 1 0.06 0.09 0
172 INT10909 Edn1 Positive_regulation of Nppb 1 0.39 0.16 0
173 INT325589 Nppa Regulation of Cacna1c 1 0.05 0 0
174 INT14790 Nppa Regulation of Edn3 1 0.45 0.7 0
175 INT325595 Nppa Negative_regulation of Ang 1 0.25 0.46 0
176 INT10907 Apoa2 Positive_regulation of Localization of Nppb 1 0.09 0.23 0
177 INT14792 Edn3 Regulation of Nppa 1 0.17 0.17 0
178 INT239401 FIG4 Regulation of NPPA 1 0.17 2.24 0
179 INT256210 NPPB Regulation of PVR 1 0.24 1.14 0
180 INT325587 Binding of Ang and Nppa 1 0.21 0.24 0
181 INT354619 AR Positive_regulation of Gene_expression of Nppa 1 0.00 0.38 0
182 INT79900 NFE2L2 Positive_regulation of Gene_expression of AQP1 1 0.03 0 0
183 INT165146 Kiss1 Regulation of Nppa 1 0.42 0 0
184 INT325606 Negative_regulation of Nppa Negative_regulation of Ang 1 0.25 0.46 0
185 INT213049 Hdl1 Regulation of Gene_expression of Nppc 1 0.09 1 0
186 INT262498 Binding of Aqp1 and Cav1 1 0.03 0.56 0
187 INT325597 Nppa Regulation of Gopc 1 0.15 0 0
188 INT91095 Naf1 Positive_regulation of Npr1 1 0.01 0.18 0
189 INT325605 Pls1 Regulation of Nppa 1 0.00 0 0
190 INT325593 Pde2a Positive_regulation of Negative_regulation of Nppa 1 0.11 0 0
191 INT191984 Ide Positive_regulation of Nppc 1 0.04 0.13 0
192 INT11122 Nppa Negative_regulation of Thop1 1 0.20 0.4 0
193 INT325588 Nppa Regulation of Localization of Rgs2 1 0.32 0 0
194 INT247031 Npr1 Positive_regulation of Prkaca 1 0.00 0 0
195 INT98626 Aqp1 Positive_regulation of Aqp4 1 0.52 0 0
196 INT325604 Nppa Regulation of Car2 1 0.23 0 0
197 INT325584 Binding of Olfml3 and Nppa 1 0.01 0.1 0
198 INT10908 Avp Positive_regulation of Localization of Nppb 1 0.42 0.23 0
199 INT91096 Naf1 Positive_regulation of Binding of Npr1 1 0.02 0.19 0
200 INT256211 NPPB Regulation of PDAP1 1 0.28 1.14 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for cGMP biosynthetic process. They are ordered first by their pain relevance and then by number of times they were reported in cGMP biosynthetic process. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT1303 Negative_regulation of Npr1 278 0.55 35.1 156.78
2 INT4259 Positive_regulation of Npr1 262 0.70 49.37 123.11
3 INT5617 Localization of Nppa 266 0.81 83.51 83.89
4 INT5623 Positive_regulation of Nppa 174 0.70 69.96 52.33
5 INT5620 Positive_regulation of Localization of Nppa 105 0.70 30.23 36.45
6 INT6196 Regulation of Nppa 83 0.62 30.31 30.18
7 INT104567 Gene_expression of Aqp1 47 0.78 44.84 28.68
8 INT8205 Negative_regulation of Nppa 77 0.59 26.43 25.72
9 INT5622 Gene_expression of Nppa 101 0.78 49.46 25.31
10 INT7017 Regulation of Npr1 45 0.52 3.38 20.05
11 INT4260 Negative_regulation of Positive_regulation of Npr1 29 0.43 4.39 19.57
12 INT6461 Gene_expression of Npr1 35 0.75 10.38 17.58
13 INT5618 Regulation of Localization of Nppa 36 0.62 13.42 17.46
14 INT9299 Positive_regulation of Positive_regulation of Npr1 32 0.53 6.65 16.72
15 INT8989 Binding of Npr1 25 0.36 5.52 14.58
16 INT14764 Negative_regulation of Localization of Nppa 28 0.59 11.29 12.82
17 INT9083 Gene_expression of Nppb 74 0.78 70.96 12.19
18 INT11121 Positive_regulation of NPPA 64 0.70 34.09 11.96
19 INT9084 Positive_regulation of Nppb 74 0.70 69.77 11.85
20 INT18001 Positive_regulation of Htr2c 21 0.67 7.63 11.39
21 INT7132 Localization of NPPA 53 0.81 19.79 10.86
22 INT13606 Negative_regulation of Negative_regulation of Npr1 13 0.40 1.21 10.01
23 INT16356 Regulation of NPPA 33 0.62 13.24 9.53
24 INT131788 Positive_regulation of NPPB 87 0.67 86.1 8.81
25 INT26487 Positive_regulation of Npr1 17 0.70 10.01 8.78
26 INT56775 Binding of Htr2c 16 0.47 3.77 8.74
27 INT9032 Regulation of Htr2c 11 0.60 2.77 7.81
28 INT6210 Binding of Nppa 39 0.47 14.35 7.21
29 INT15156 Positive_regulation of Localization of NPPA 21 0.70 8.61 6.97
30 INT26489 Negative_regulation of Npr1 15 0.59 5.7 6.79
31 INT6565 Positive_regulation of Positive_regulation of Nppa 14 0.70 4.04 6.76
32 INT62950 Gene_expression of NPPB 73 0.75 65.91 6.54
33 INT6459 Regulation of Negative_regulation of Npr1 10 0.53 0.16 6.44
34 INT7021 Positive_regulation of Negative_regulation of Npr1 8 0.22 1.02 6.36
35 INT6195 Transcription of Npr1 9 0.69 3 5.94
36 INT49477 Gene_expression of Htr2c 12 0.75 3.26 5.73
37 INT7018 Positive_regulation of Gene_expression of Npr1 10 0.59 5.09 5.66
38 INT13706 Localization of Npr1 10 0.59 0.83 5.42
39 INT156134 Regulation of Gene_expression of Aqp1 5 0.59 7.2 5.3
40 INT85328 Negative_regulation of Aqp1 5 0.54 6.02 4.94
41 INT11064 Positive_regulation of NPR1 24 0.49 14.63 4.78
42 INT7298 Gene_expression of NPPA 35 0.70 18.23 4.76
43 INT49748 Binding of HTR2C 10 0.47 3.03 4.76
44 INT5624 Transcription of Nppa 19 0.69 8.52 4.72
45 INT79902 Gene_expression of AQP1 33 0.78 24.72 4.55
46 INT45159 Regulation of Nppb 16 0.54 13.57 4.46
47 INT5619 Positive_regulation of Gene_expression of Nppa 21 0.70 11.95 4.41
48 INT73434 Negative_regulation of Nppa 8 0.35 3.86 4.31
49 INT52402 Negative_regulation of Htr2c 7 0.42 1.46 4.21
50 INT28983 Regulation of Htr2b 3 0.22 0.26 3.96
51 INT16408 Negative_regulation of Nppb 14 0.53 5.49 3.74
52 INT85326 Positive_regulation of Aqp1 7 0.65 5.9 3.71
53 INT157056 Gene_expression of Gucy1a2 4 0.09 0.71 3.67
54 INT159472 Localization of NPPB 32 0.79 33.67 3.59
55 INT104570 Localization of Aqp1 8 0.77 5.83 3.51
56 INT63621 Transcription of Htr2c 6 0.52 0.62 3.49
57 INT9085 Localization of Nppb 32 0.81 15.1 3.47
58 INT55236 Regulation of Htr2c 6 0.44 3.31 3.36
59 INT240127 Binding of Nppb 19 0.37 22.42 3.3
60 INT16357 Negative_regulation of NPPA 23 0.58 12.37 2.98
61 INT6193 Regulation of Gene_expression of Nppa 6 0.45 2.02 2.93
62 INT54449 Positive_regulation of Transcription of Npr1 3 0.45 1.73 2.81
63 INT99104 Gene_expression of Npr1 5 0.78 3.31 2.8
64 INT65000 Positive_regulation of Positive_regulation of Htr2c 4 0.67 0.69 2.8
65 INT26205 Positive_regulation of Positive_regulation of NPR1 3 0.24 1.57 2.52
66 INT80463 Localization of Gucy1a2 4 0.07 0.49 2.5
67 INT20498 Negative_regulation of Positive_regulation of Nppa 9 0.59 4.5 2.43
68 INT11065 Gene_expression of NPR1 6 0.55 3.41 2.32
69 INT77309 Positive_regulation of Htr2c 3 0.49 2.72 2.25
70 INT64505 Localization of Htr2c 3 0.78 0.87 2.24
71 INT69020 Gene_expression of Htr2c 9 0.74 6.09 2.22
72 INT120752 Positive_regulation of Gene_expression of NPPB 17 0.67 16.4 2.21
73 INT2611 Negative_regulation of AQP1 17 0.39 10.04 2.15
74 INT141721 Binding of Aqp1 5 0.37 1.77 2.15
75 INT6460 Regulation of Gene_expression of Npr1 4 0.52 2.19 2.13
76 INT203308 Regulation of Aqp1 4 0.48 2.59 2.13
77 INT25461 Negative_regulation of Regulation of Nppa 2 0.43 0.22 1.97
78 INT84264 Regulation of NPPB 22 0.61 21.18 1.94
79 INT83218 Negative_regulation of Gucy1a2 6 0.24 0.82 1.9
80 INT50658 Positive_regulation of HTR2C 5 0.67 2.3 1.9
81 INT183450 Positive_regulation of GUCY2C 6 0.04 4.45 1.88
82 INT26370 Positive_regulation of Positive_regulation of NPPA 4 0.60 0.67 1.87
83 INT14413 Regulation of Positive_regulation of Npr1 7 0.62 0.71 1.78
84 INT74088 Negative_regulation of Positive_regulation of Htr2c 1 0.41 0 1.75
85 INT11098 Regulation of NPR1 5 0.37 1.39 1.74
86 INT55704 Positive_regulation of Gucy1a2 6 0.50 1.24 1.7
87 INT15155 Regulation of Localization of NPPA 8 0.62 2.67 1.65
88 INT43045 Negative_regulation of Regulation of Npr1 3 0.12 0.17 1.65
89 INT161217 Positive_regulation of Htr2b 1 0.67 2.55 1.58
90 INT26488 Regulation of Npr1 4 0.39 0.88 1.56
91 INT31921 Negative_regulation of Localization of Npr1 2 0.17 0 1.51
92 INT11057 Protein_catabolism of Nppa 11 0.94 3.34 1.47
93 INT6194 Regulation of Transcription of Npr1 2 0.05 0.08 1.46
94 INT211054 Positive_regulation of AQP1 3 0.33 4.53 1.41
95 INT67465 Positive_regulation of Regulation of Npr1 1 0.05 0.14 1.4
96 INT73432 Gene_expression of Nppa 32 0.59 21.04 1.39
97 INT327824 Positive_regulation of Gene_expression of Aqp1 4 0.67 5.4 1.37
98 INT73553 Gene_expression of Aqp1 23 0.67 4.65 1.34
99 INT53160 Gene_expression of HTR2C 3 0.75 0.62 1.3
100 INT272340 Transcription of Htr2c 1 0.52 2.77 1.28
101 INT78355 Negative_regulation of Gene_expression of Npr1 2 0.06 0.15 1.22
102 INT11099 Localization of NPR1 5 0.67 1.49 1.21
103 INT89756 Positive_regulation of Positive_regulation of Npr1 2 0.47 0.9 1.19
104 INT125338 Regulation of HTR2C 2 0.26 1.32 1.18
105 INT40170 Regulation of Localization of Npr1 2 0.05 0.12 1.16
106 INT161216 Positive_regulation of Gene_expression of Htr2b 1 0.49 1.87 1.16
107 INT81136 Binding of Npr1 6 0.48 1.45 1.15
108 INT161219 Gene_expression of Htr2b 4 0.75 2.01 1.14
109 INT131351 Positive_regulation of Gene_expression of Nppb 2 0.50 13.72 1.14
110 INT91427 Gene_expression of Gucy2c 2 0.37 0.18 1
111 INT166889 Positive_regulation of Gene_expression of AQP1 10 0.70 6.43 0.99
112 INT133846 Binding of NPPB 14 0.42 11.52 0.98
113 INT11100 Positive_regulation of Gene_expression of NPR1 2 0.37 1.49 0.98
114 INT16371 Positive_regulation of Gene_expression of NPPA 7 0.45 3.62 0.96
115 INT30157 Gene_expression of Htr2b 2 0.48 0 0.94
116 INT183362 Regulation of AQP1 3 0.23 1.49 0.92
117 INT23921 Negative_regulation of NPPB 13 0.58 16.19 0.9
118 INT29759 Negative_regulation of Negative_regulation of Nppa 3 0.58 1.5 0.9
119 INT11066 Negative_regulation of NPR1 5 0.27 0.89 0.88
120 INT72715 Positive_regulation of Nppc 4 0.39 1.55 0.87
121 INT15587 Protein_catabolism of NPPA 4 0.71 1.55 0.87
122 INT16587 Regulation of Negative_regulation of Nppa 3 0.53 0.84 0.82
123 INT42356 Negative_regulation of Binding of Npr1 1 0.32 0.37 0.82
124 INT32513 Regulation of Localization of NPR1 3 0.36 0.84 0.81
125 INT7297 Binding of NPPA 8 0.45 5.33 0.79
126 INT80118 Gene_expression of NPPC 2 0.68 4.14 0.77
127 INT16537 Regulation of Positive_regulation of Nppa 2 0.45 1.44 0.76
128 INT62702 Negative_regulation of HTR2C 2 0.42 1.14 0.75
129 INT5621 Positive_regulation of Transcription of Nppa 5 0.50 4.97 0.74
130 INT19316 Positive_regulation of Localization of Nppb 2 0.50 3.15 0.73
131 INT54452 Regulation of Regulation of Npr1 1 0.03 0 0.72
132 INT5569 Phosphorylation of Npr1 3 0.18 0.61 0.7
133 INT125261 Positive_regulation of Gene_expression of Htr2c 2 0.67 2.22 0.7
134 INT70530 Binding of NPR1 3 0.17 0.71 0.65
135 INT54167 Negative_regulation of Positive_regulation of NPPA 4 0.42 1.26 0.63
136 INT57127 Binding of Htr2b 2 0.36 0.05 0.63
137 INT272356 Positive_regulation of Transcription of Htr2c 1 0.45 1.66 0.63
138 INT109081 Localization of Nppa 9 0.59 2.72 0.61
139 INT254132 Positive_regulation of Localization of NPPB 2 0.40 2.9 0.58
140 INT51718 Positive_regulation of Negative_regulation of Nppa 3 0.47 0.79 0.57
141 INT100754 Negative_regulation of Binding of Htr2c 1 0.41 0.49 0.57
142 INT89855 Localization of Npr1 1 0.20 0.32 0.57
143 INT84084 Binding of Gucy1a2 2 0.08 0.38 0.56
144 INT7293 Negative_regulation of Binding of Nppa 5 0.43 1.4 0.55
145 INT139780 Binding of AQP1 7 0.32 4.62 0.54
146 INT91426 Positive_regulation of Gucy2c 1 0.37 0.06 0.54
147 INT183375 Binding of Nppa 14 0.38 8.95 0.51
148 INT230986 Positive_regulation of Transcription of Htr2c 1 0.45 0.25 0.49
149 INT70532 Regulation of Regulation of NPR1 1 0.12 0.31 0.49
150 INT19315 Phosphorylation of Nppb 2 0.55 0.23 0.47
151 INT5625 Regulation of Transcription of Nppa 2 0.26 0.29 0.46
152 INT174055 Negative_regulation of Htr2c 5 0.41 2.63 0.45
153 INT148156 Positive_regulation of Gene_expression of HTR2C 1 0.67 0.26 0.45
154 INT146313 Negative_regulation of Localization of HTR2C 1 0.42 0 0.45
155 INT19317 Regulation of Localization of Nppb 1 0.27 0.22 0.45
156 INT312826 Negative_regulation of Nppc 1 0.03 1.36 0.45
157 INT19592 Localization of AQP1 4 0.81 1.09 0.44
158 INT327786 Negative_regulation of Gene_expression of AQP1 3 0.29 4.21 0.44
159 INT146315 Positive_regulation of Localization of HTR2C 1 0.45 0 0.44
160 INT146314 Localization of HTR2C 1 0.68 0 0.44
161 INT65558 Regulation of Nppc 1 0.21 0.79 0.44
162 INT161218 Positive_regulation of Positive_regulation of Htr2b 1 0.67 0.69 0.43
163 INT166903 Negative_regulation of Gene_expression of NPPB 5 0.43 4.18 0.41
164 INT76874 Negative_regulation of Htr2b 1 0.07 0 0.41
165 INT6563 Positive_regulation of Regulation of Nppa 1 0.33 0.44 0.41
166 INT72717 Gene_expression of Nppc 8 0.51 6.25 0.39
167 INT116066 Positive_regulation of Nppc 1 0.02 0.44 0.39
168 INT32533 Negative_regulation of Gene_expression of Nppa 2 0.32 1.93 0.38
169 INT146994 Regulation of NPPC 2 0.22 1.46 0.37
170 INT203374 Positive_regulation of Regulation of Aqp1 2 0.36 0.91 0.37
171 INT70531 Negative_regulation of Negative_regulation of NPR1 1 0.19 0.24 0.37
172 INT59593 Regulation of Gene_expression of NPPA 2 0.41 2.51 0.36
173 INT42659 Positive_regulation of Localization of Npr1 1 0.10 0.36 0.34
174 INT242293 Positive_regulation of Positive_regulation of NPPB 5 0.56 2.92 0.33
175 INT211023 Positive_regulation of Gene_expression of Htr2c 2 0.45 2.03 0.33
176 INT32566 Positive_regulation of Localization of NPR1 1 0.58 0.17 0.33
177 INT170161 Localization of NPPC 2 0.62 2.06 0.32
178 INT80117 Positive_regulation of NPPC 3 0.61 0.6 0.31
179 INT131352 Regulation of Gene_expression of Nppb 2 0.40 3.18 0.31
180 INT293551 Regulation of Positive_regulation of Aqp1 1 0.13 0 0.31
181 INT252267 Positive_regulation of Positive_regulation of GUCY2C 1 0.03 0.59 0.3
182 INT72112 Positive_regulation of Positive_regulation of Gucy1a2 1 0.07 0 0.3
183 INT242985 Regulation of Gene_expression of Npr1 1 0.03 0.85 0.29
184 INT149920 Regulation of Gucy1a2 1 0.11 0.35 0.28
185 INT17158 Regulation of Protein_catabolism of Nppa 1 0.24 0.1 0.28
186 INT52742 Negative_regulation of Negative_regulation of Nppb 1 0.08 0.15 0.27
187 INT55703 Negative_regulation of Positive_regulation of Gucy1a2 1 0.31 0.28 0.27
188 INT159473 Regulation of Localization of NPPB 2 0.61 1 0.25
189 INT211029 Negative_regulation of Gene_expression of Htr2c 1 0.56 2.54 0.25
190 INT76401 Localization of Nppc 2 0.54 1.09 0.24
191 INT131350 Transcription of Nppb 2 0.72 4.61 0.24
192 INT57126 Transcription of Htr2b 1 0.33 0 0.24
193 INT80465 Regulation of Localization of Gucy1a2 1 0.03 0.49 0.23
194 INT170164 Regulation of Gene_expression of NPPC 1 0.37 0.94 0.23
195 INT62840 Negative_regulation of Binding of HTR2C 1 0.42 0 0.23
196 INT252264 Binding of GUCY2C 1 0.01 0.34 0.22
197 INT102607 Transcription of HTR2C 1 0.52 0.28 0.22
198 INT95576 Gene_expression of GUCY2C 4 0.42 1.78 0.21
199 INT10900 Positive_regulation of Positive_regulation of Nppb 3 0.41 3.53 0.21
200 INT16358 Positive_regulation of Negative_regulation of NPPA 2 0.41 0.83 0.21
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