GO:0006206

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Name pyrimidine base metabolic process
Categary Process
Go Slim No
Go Link GO:0006206
Unique Molecular Interactions 42
Total Molecular Interactions 70
Total Single Events 600
Pain Genes Associated 12

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for pyrimidine base metabolic process. They are ordered first by their pain relevance and then by number of times they were reported for pyrimidine base metabolic process. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT73116 TYMS Negative_regulation of DNMT3B 1 0.24 0 1.6
2 INT73115 TYMS Negative_regulation of Positive_regulation of DNMT3B 1 0.24 0 1.6
3 INT111828 UPB1 Positive_regulation of Oprm1 1 0.00 0.85 1.53
4 INT45891 Tyms Positive_regulation of Localization of Acot1 1 0.02 0 1.23
5 INT164722 Avp Regulation of NT5C 1 0.06 0.88 1.15
6 INT341897 Positive_regulation of NT5C3 Positive_regulation of Positive_regulation of Oxt 1 0.32 0.42 1.07
7 INT178576 CNTN2 Positive_regulation of DPYD 1 0.05 2.18 0.76
8 INT287132 Binding of NT5E and Comt 1 0.03 0.11 0.73
9 INT164721 Binding of NT5C and Acot1 1 0.04 0.45 0.65
10 INT164723 Binding of Avp and NT5C 1 0.07 0.45 0.65
11 INT63152 Ppt1 Regulation of Gene_expression of Pd 1 0.01 0 0.43
12 INT13715 PDYN Positive_regulation of TYMS 1 0.27 0 0.39
13 INT287131 Negative_regulation of Binding of NT5E and Comt 1 0.03 0.06 0.23
14 INT21576 NT5C3 Negative_regulation of Gene_expression of TIMP1 1 0.03 0.25 0.2
15 INT21578 NT5C3 Regulation of Gene_expression of IL4I1 1 0.01 0.24 0.19
16 INT48595 NT5C3 Positive_regulation of CA2 1 0.01 0 0.13
17 INT48594 NT5C3 Positive_regulation of NA 1 0.00 0 0.13
18 INT287130 Positive_regulation of Binding of NT5E and Comt 1 0.04 0 0.12
19 INT62775 Regulation of Binding of NT5E and OPRK1 1 0.03 0 0.1
20 INT62776 Binding of NT5E and OPRK1 1 0.02 0 0.1
21 INT301921 UCK2 Regulation of Gene_expression of FGF2 1 0.01 1.22 0.08
22 INT56584 B2M Regulation of CDA 1 0.00 0.39 0.05
23 INT331961 Binding of Tbxa2r and Tymp 1 0.03 0.07 0.03
24 INT331960 Positive_regulation of Binding of Esr1 and Tymp 1 0.00 0.15 0.03
25 INT331958 Binding of Esr1 and Tymp 1 0.00 0.15 0.03
26 INT337066 Binding of DPYD and FRA1E 1 0.19 0.8 0
27 INT339404 Binding of Ar and Tymp 1 0.10 0.06 0
28 INT339403 Negative_regulation of Binding of Ar and Tymp 1 0.12 0 0
29 INT339402 Binding of Dlat and Tymp 1 0.19 0 0
30 INT336713 Binding of CDA and GNPTAB 1 0.02 0.77 0
31 INT342252 Binding of Ercc1 and Tymp 1 0.29 1.24 0
32 INT339405 Negative_regulation of Binding of Dlat and Tymp 1 0.22 0 0
33 INT294880 DPYD Positive_regulation of Ephb1 1 0.00 0.53 0
34 INT339407 Negative_regulation of Binding of AR and Tymp 1 0.04 0 0
35 INT294828 DPYD Positive_regulation of PIK3CB 1 0.00 0.51 0
36 INT339406 Binding of AR and Tymp 1 0.03 0.06 0
37 INT342251 Binding of Trp53 and Tymp 1 0.21 1.01 0
38 INT331957 Tbxa2r Positive_regulation of Gene_expression of Tymp 1 0.04 0.08 0
39 INT147144 E2F1 Positive_regulation of Transcription of TYMS 1 0.26 0 0
40 INT294827 DPYD Positive_regulation of Gene_expression of REXO1 1 0.01 0.47 0
41 INT294831 DPYD Positive_regulation of Positive_regulation of RASGRP1 1 0.00 0.53 0
42 INT234144 Fig4 Negative_regulation of Transcription of Tyms 1 0.05 0.18 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for pyrimidine base metabolic process. They are ordered first by their pain relevance and then by number of times they were reported in pyrimidine base metabolic process. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT10261 Negative_regulation of Pd 16 0.42 5.55 7.4
2 INT125378 Gene_expression of UPB1 4 0.59 0.25 4.49
3 INT62784 Gene_expression of NT5E 46 0.65 15.95 3.72
4 INT114826 Gene_expression of Tymp 40 0.58 22.97 3.71
5 INT232667 Binding of Pd 17 0.16 20.76 3.58
6 INT63132 Positive_regulation of Pd 10 0.13 5.86 3.15
7 INT52911 Gene_expression of Tyms 10 0.42 2.24 2.66
8 INT3123 Localization of Tyms 6 0.78 0.85 2.6
9 INT63135 Transcription of Pd 5 0.04 1.91 2.59
10 INT213681 Gene_expression of TYMS 9 0.33 8.96 2.45
11 INT57115 Negative_regulation of NT5E 8 0.57 4.35 2.03
12 INT213676 Negative_regulation of Gene_expression of TYMS 2 0.08 1.95 1.83
13 INT174240 Negative_regulation of TYMS 12 0.57 6.35 1.82
14 INT48596 Positive_regulation of NT5C3 3 0.45 0.53 1.79
15 INT111112 Negative_regulation of UPB1 2 0.32 0.1 1.68
16 INT164720 Positive_regulation of Localization of NT5C 1 0.06 0.87 1.39
17 INT96420 Positive_regulation of NT5E 9 0.49 3.7 1.38
18 INT155036 Localization of NT5E 6 0.73 4.1 1.35
19 INT63136 Positive_regulation of Transcription of Pd 1 0.02 0 1.34
20 INT106261 Negative_regulation of DPYD 16 0.59 15.02 1.19
21 INT52912 Binding of Tyms 5 0.46 0.78 1.16
22 INT10262 Protein_catabolism of Pd 2 0.86 0.3 1.15
23 INT114827 Positive_regulation of Gene_expression of Tymp 13 0.45 5.69 1.11
24 INT94690 Gene_expression of DPYD 12 0.75 4.6 1.07
25 INT341885 Positive_regulation of Localization of NT5C3 1 0.49 0.41 1.07
26 INT231528 Localization of NT5C3 2 0.73 1.78 1.06
27 INT164416 Gene_expression of CDA 8 0.64 5.17 1.02
28 INT189991 Positive_regulation of Tymp 2 0.07 4.93 1.01
29 INT103240 Negative_regulation of Tyms 4 0.57 1.7 0.99
30 INT165982 Regulation of UPB1 1 0.33 0.08 0.9
31 INT63137 Regulation of Pd 10 0.12 4.01 0.81
32 INT63134 Regulation of Transcription of Pd 2 0.03 0.48 0.77
33 INT287128 Protein_catabolism of NT5E 2 0.11 0.64 0.76
34 INT178587 Positive_regulation of DPYD 4 0.50 4.7 0.74
35 INT138555 Negative_regulation of Tymp 3 0.39 3.31 0.74
36 INT63138 Negative_regulation of Positive_regulation of Pd 1 0.01 0 0.74
37 INT294133 Regulation of Gene_expression of NT5E 4 0.12 1.36 0.71
38 INT164717 Localization of NT5C 1 0.09 0.43 0.69
39 INT164718 Regulation of NT5C 3 0.19 1.36 0.62
40 INT25002 Negative_regulation of Protein_catabolism of Pd 1 0.02 0 0.62
41 INT63133 Gene_expression of Pd 13 0.18 5.31 0.61
42 INT155035 Binding of NT5E 3 0.36 1.78 0.61
43 INT271374 Localization of Tymp 3 0.23 1.87 0.6
44 INT164719 Regulation of Regulation of NT5C 1 0.03 0.44 0.58
45 INT58188 Localization of CDA 1 0.62 0.09 0.55
46 INT134902 Positive_regulation of Tymp 11 0.37 3.06 0.53
47 INT271377 Positive_regulation of Localization of Tymp 2 0.16 0.68 0.51
48 INT13717 Positive_regulation of TYMS 3 0.40 1.64 0.49
49 INT251661 Phosphorylation of NT5E 2 0.21 1.59 0.46
50 INT301932 Negative_regulation of UCK2 1 0.03 5.03 0.43
51 INT178586 Localization of DPYD 1 0.36 0.76 0.42
52 INT96419 Positive_regulation of Gene_expression of NT5E 3 0.49 1.46 0.41
53 INT94691 Binding of DPYD 2 0.47 0 0.39
54 INT331941 Binding of Tymp 7 0.27 4.57 0.37
55 INT154144 Gene_expression of Tymp 9 0.43 2.36 0.36
56 INT287129 Regulation of NT5E 3 0.12 1.02 0.32
57 INT331946 Negative_regulation of Tymp 1 0.06 0.08 0.32
58 INT138554 Positive_regulation of Negative_regulation of Tymp 1 0.13 0.7 0.28
59 INT301935 Gene_expression of UCK2 5 0.13 4.4 0.27
60 INT331944 Negative_regulation of Gene_expression of Tymp 1 0.04 0 0.26
61 INT248408 Positive_regulation of Gene_expression of Tymp 2 0.32 1.58 0.25
62 INT331943 Regulation of Tymp 1 0.04 0.7 0.25
63 INT248409 Negative_regulation of Gene_expression of Tymp 1 0.13 1.25 0.25
64 INT354743 Gene_expression of NT5C 1 0.20 1.72 0.25
65 INT237464 Positive_regulation of Negative_regulation of TYMS 2 0.20 0.53 0.23
66 INT354726 Binding of Tymp 1 0.30 1.08 0.23
67 INT294138 Positive_regulation of Localization of NT5E 1 0.14 0.41 0.21
68 INT294141 Regulation of Localization of NT5E 1 0.12 0.42 0.21
69 INT301934 Regulation of UCK2 1 0.02 1.74 0.19
70 INT21580 Negative_regulation of NT5C3 1 0.04 0.23 0.19
71 INT154134 Regulation of Tymp 4 0.09 1.19 0.17
72 INT284968 Positive_regulation of CDA 2 0.05 0.34 0.15
73 INT331952 Positive_regulation of Binding of Tymp 1 0.05 0.07 0.15
74 INT331955 Phosphorylation of Tymp 1 0.08 0.07 0.13
75 INT279806 Regulation of TYMS 2 0.05 1 0.12
76 INT284953 Protein_catabolism of CDA 1 0.07 1.18 0.1
77 INT331950 Positive_regulation of Positive_regulation of Tymp 1 0.05 0.3 0.1
78 INT331945 Regulation of Positive_regulation of Tymp 1 0.04 0.1 0.09
79 INT331947 Positive_regulation of Regulation of Tymp 1 0.05 0.07 0.09
80 INT23647 Negative_regulation of CDA 3 0.38 1.48 0.08
81 INT106363 Positive_regulation of Tyms 2 0.02 0.66 0.08
82 INT301933 Binding of UCK2 1 0.02 2.58 0.08
83 INT354744 Binding of NT5C 1 0.10 0.29 0.08
84 INT236887 Positive_regulation of Gene_expression of Pd 4 0.13 1.24 0.07
85 INT162255 Positive_regulation of Binding of Tyms 2 0.45 0.64 0.07
86 INT331949 Negative_regulation of Phosphorylation of Tymp 1 0.04 0.07 0.07
87 INT147148 Transcription of TYMS 2 0.30 0.5 0.06
88 INT237463 Regulation of Gene_expression of TYMS 1 0.12 0.51 0.06
89 INT234136 Transcription of Tyms 1 0.48 0.77 0.06
90 INT237466 Regulation of Transcription of TYMS 1 0.26 0.5 0.06
91 INT331951 Positive_regulation of Phosphorylation of Tymp 1 0.05 0 0.06
92 INT234129 Positive_regulation of Transcription of Tyms 1 0.35 0.12 0.06
93 INT288233 Localization of TYMS 2 0.22 2.17 0.04
94 INT288232 Binding of TYMS 2 0.11 2.77 0.04
95 INT331954 Regulation of Binding of Tymp 1 0.04 0 0.04
96 INT353312 Regulation of Positive_regulation of Tymp 1 0.09 0.15 0.04
97 INT181315 Regulation of DPYD 2 0.54 3.64 0
98 INT106364 Positive_regulation of Gene_expression of Tyms 2 0.01 0.65 0
99 INT331956 Protein_catabolism of Tymp 1 0.08 0.2 0
100 INT326142 Positive_regulation of Gene_expression of TYMS 1 0.16 2.47 0
101 INT147145 Negative_regulation of Transcription of TYMS 1 0.15 0 0
102 INT234130 Negative_regulation of Transcription of Tyms 1 0.30 0.13 0
103 INT223288 Protein_catabolism of DPYD 1 0.46 0.11 0
104 INT337068 Transcription of DPYD 1 0.60 0 0
105 INT154136 Regulation of Gene_expression of Tymp 1 0.01 0.26 0
106 INT303640 Gene_expression of NT5C3 1 0.07 0.73 0
107 INT315819 Regulation of Gene_expression of CDA 1 0.37 0.63 0
108 INT331942 Regulation of Gene_expression of Tymp 1 0.03 0.14 0
109 INT331953 Regulation of Protein_catabolism of Tymp 1 0.04 0.08 0
110 INT329193 Regulation of Binding of NT5E 1 0.07 0.67 0
111 INT234132 Regulation of Transcription of Tyms 1 0.19 0.16 0
112 INT234137 Regulation of Gene_expression of Tyms 1 0.19 0.16 0
113 INT236888 Negative_regulation of Transcription of Pd 1 0.03 0.64 0
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