GO:0006259

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Name DNA metabolic process
Categary Process
Go Slim Yes
Go Link GO:0006259
Unique Molecular Interactions 91
Total Molecular Interactions 124
Total Single Events 1417
Pain Genes Associated 16

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for DNA metabolic process. They are ordered first by their pain relevance and then by number of times they were reported for DNA metabolic process. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT149680 Binding of Parp1 and Oprm1 1 0.53 0 1.66
2 INT19535 Binding of ADRA1D and ALB 3 0.42 0.8 1.15
3 INT86960 ADRA1D Negative_regulation of Prl 1 0.00 0 0.97
4 INT106457 SPOP Positive_regulation of Negative_regulation of ADRA1D 1 0.02 0.56 0.84
5 INT16491 Binding of ADRA1D and Serpinf2 1 0.02 0.78 0.78
6 INT16498 Binding of ADRA1D and LPA 1 0.10 0.78 0.78
7 INT16493 Positive_regulation of Binding of ADRA1D and Serpinf2 1 0.02 0.78 0.78
8 INT16497 Positive_regulation of Binding of ADRA1D and LPA 1 0.10 0.78 0.78
9 INT287132 Binding of NT5E and Comt 1 0.03 0.11 0.73
10 INT149684 Negative_regulation of Parp1 Positive_regulation of Oprm1 1 0.51 0 0.65
11 INT18231 Binding of ADRA1D and HP 2 0.14 0.17 0.64
12 INT149681 Parp1 Regulation of Transcription of Oprm1 1 0.67 0 0.63
13 INT149682 Parp1 Negative_regulation of Oprm1 1 0.47 0 0.6
14 INT149683 Parp1 Negative_regulation of Transcription of Oprm1 1 0.47 0 0.58
15 INT55873 Binding of ADRA1D and GNRH1 1 0.08 0 0.54
16 INT55872 Binding of ADRA1D and CRH 1 0.26 0 0.54
17 INT10944 Binding of ADRA1D and TRPV1 1 0.01 0 0.35
18 INT169612 OGFR Regulation of RAN 1 0.23 0.14 0.3
19 INT39317 Binding of ADRA1D and PTAFR 1 0.54 0.54 0.3
20 INT347562 Abat Positive_regulation of Mki67 1 0.03 0 0.3
21 INT123221 Binding of ADRA1D and TNFAIP6 1 0.03 0.76 0.25
22 INT287131 Negative_regulation of Binding of NT5E and Comt 1 0.03 0.06 0.23
23 INT119717 Binding of ADRA1D and F12 1 0.35 0.23 0.23
24 INT169611 Binding of RAN and OGFR 1 0.24 0.19 0.23
25 INT341378 Positive_regulation of Ros1 Positive_regulation of Parp1 1 0.01 1.08 0.22
26 INT126791 RASL12 Positive_regulation of ADRA1D 1 0.24 2.62 0.22
27 INT287693 Parp1 Positive_regulation of Positive_regulation of Nfkb1 1 0.07 0.54 0.2
28 INT6697 Binding of GLUL and Positive_regulation of Positive_regulation of ADRA1D 1 0.23 0.16 0.19
29 INT28432 ADRA1D Positive_regulation of MPG 1 0.54 0.2 0.19
30 INT45029 Binding of ADRA1D and CELA3B 1 0.32 0.17 0.17
31 INT22820 ADRA1D Regulation of ELANE 1 0.21 0 0.15
32 INT294109 Binding of DNASE1L3 and HTR1B 1 0.01 0 0.15
33 INT136605 Binding of OPRD1 and RAN 1 0.37 0.54 0.15
34 INT136606 Binding of RAN and DLL1 1 0.33 0.45 0.15
35 INT294108 Binding of DNASE1L3 and LMOD1 1 0.08 0 0.14
36 INT294106 Binding of DNASE1L3 and DRD5 1 0.02 0 0.14
37 INT336503 Parp1 Positive_regulation of Tubgcp2 1 0.11 0.52 0.13
38 INT336504 Parp1 Positive_regulation of Mcpt3 1 0.11 0.52 0.13
39 INT336506 Parp1 Positive_regulation of Cxcl2 1 0.16 0.52 0.13
40 INT336505 Parp1 Positive_regulation of Mcpt1 1 0.14 0.52 0.13
41 INT59807 ADRA1D Positive_regulation of PLCB1 1 0.33 0 0.13
42 INT59810 ADRA1D Positive_regulation of AGT 1 0.01 0 0.13
43 INT287130 Positive_regulation of Binding of NT5E and Comt 1 0.04 0 0.12
44 INT37489 Binding of ADRA1D and Alb 1 0.34 0.84 0.11
45 INT62775 Regulation of Binding of NT5E and OPRK1 1 0.03 0 0.1
46 INT62776 Binding of NT5E and OPRK1 1 0.02 0 0.1
47 INT96563 Binding of ADRA1D and UCN2 1 0.19 1.34 0.1
48 INT87038 Binding of ADRA1D and Col5a3 1 0.03 0.48 0.09
49 INT189957 Binding of LDHA and Pttg1 1 0.05 0.35 0.08
50 INT253193 Ros1 Regulation of Parp1 1 0.01 0.57 0.05
51 INT333841 Binding of Rad51 and Mir17 1 0.02 0.52 0.05
52 INT322358 Binding of Parp1 and Casp3 1 0.05 1.08 0.04
53 INT261962 Binding of Parp1 and El4 1 0.19 1.33 0.03
54 INT250796 Tlr4 Positive_regulation of Parp1 1 0.14 1 0.03
55 INT326045 Epo Positive_regulation of Mki67 1 0.16 0.18 0.03
56 INT326050 Csf2 Positive_regulation of Mki67 1 0.15 0.18 0.03
57 INT211335 Binding of MET and MKI67 1 0.02 1.6 0
58 INT225479 Binding of Parp1 and Acsl1 1 0.00 0 0
59 INT207817 Negative_regulation of Parp1 Positive_regulation of Atm 1 0.53 0.2 0
60 INT253003 Pttg1 Regulation of Gene_expression of Id3 1 0.08 0.07 0
61 INT211336 Binding of MKI67 and VEGFA 1 0.08 4.94 0
62 INT211333 Binding of HGF and MKI67 1 0.04 1.6 0
63 INT253004 Anapc1 Positive_regulation of Binding of Pttg1 1 0.47 0 0
64 INT207815 Parp1 Negative_regulation of Phosphorylation of Atm 1 0.42 0.15 0
65 INT207816 Parp1 Regulation of Positive_regulation of Atm 1 0.51 0.21 0
66 INT308927 Gtf2i Positive_regulation of Gene_expression of Parp1 1 0.24 0 0
67 INT191183 Binding of GRB2 and RECQL5 1 0.37 0.17 0
68 INT252889 Binding of PTTG2 and PTTG3P 1 0.06 0.08 0
69 INT98356 ADRA1D Positive_regulation of Positive_regulation of ESR1 1 0.02 0.05 0
70 INT186050 IFI27 Regulation of Gene_expression of MKI67 1 0.13 0.67 0
71 INT328422 Protein_catabolism of Neu1 Positive_regulation of Dnase2b 1 0.01 0.67 0
72 INT253020 Pttg1 Negative_regulation of THBS1 1 0.03 0.16 0
73 INT253019 APC Positive_regulation of Protein_catabolism of Pttg1 1 0.06 0 0
74 INT253012 APC Positive_regulation of Binding of Pttg1 1 0.06 0 0
75 INT170458 Binding of MKI67 and THY1 1 0.01 0 0
76 INT225614 Binding of XRCC5 and Parp1 1 0.09 0 0
77 INT341377 Gene_expression of Ros1 Positive_regulation of Parp1 1 0.01 1.03 0
78 INT233020 SFTPA1 Negative_regulation of Parp1 1 0.00 0.58 0
79 INT191186 Binding of EGFR and RECQL5 1 0.35 0.34 0
80 INT189956 TP53 Positive_regulation of Gene_expression of Pttg1 1 0.06 1.21 0
81 INT322363 TNF Positive_regulation of Positive_regulation of Parp1 1 0.02 1.54 0
82 INT252907 Binding of PTTG1 and PTTG2 1 0.07 0.08 0
83 INT207813 Atm Regulation of Gene_expression of Parp1 1 0.44 0.31 0
84 INT305543 Binding of Top2a and Trp53 1 0.37 0.91 0
85 INT251822 Binding of POLG and C10orf2 1 0.42 0.29 0
86 INT253005 Binding of Zic2 and Pttg1 1 0.02 0.57 0
87 INT252908 Binding of PTTG3P and GOPC 1 0.01 0.08 0
88 INT207814 Negative_regulation of Parp1 Positive_regulation of Positive_regulation of Atm 1 0.53 0.08 0
89 INT207812 Binding of Parp1 and Atm 1 0.54 0.99 0
90 INT253006 Anapc1 Positive_regulation of Protein_catabolism of Pttg1 1 0.51 0 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for DNA metabolic process. They are ordered first by their pain relevance and then by number of times they were reported in DNA metabolic process. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT10285 Binding of ADRA1D 102 0.47 25.82 31.11
2 INT825 Negative_regulation of ADRA1D 54 0.58 20.25 22.78
3 INT3593 Gene_expression of ADRA1D 70 0.75 29.48 20.87
4 INT6699 Positive_regulation of ADRA1D 65 0.70 22.72 20.31
5 INT7523 Regulation of ADRA1D 42 0.45 11.63 14.52
6 INT49866 Negative_regulation of Parp1 53 0.58 35.37 8.84
7 INT123813 Positive_regulation of Parp1 74 0.70 65.36 8.56
8 INT256 Localization of ADRA1D 11 0.78 2.91 6.85
9 INT131944 Gene_expression of Mki67 30 0.53 6.58 5.63
10 INT62784 Gene_expression of NT5E 46 0.65 15.95 3.72
11 INT27694 Positive_regulation of Positive_regulation of ADRA1D 10 0.70 1.52 3.57
12 INT79270 Gene_expression of MKI67 113 0.77 63.52 3.38
13 INT123815 Gene_expression of Parp1 42 0.67 27.82 3.02
14 INT107677 Positive_regulation of Parp1 7 0.45 9.77 3
15 INT19539 Positive_regulation of Gene_expression of ADRA1D 10 0.67 9.4 2.9
16 INT39344 Gene_expression of DNASE1L3 12 0.54 2.25 2.88
17 INT107674 Negative_regulation of Parp1 7 0.27 8.91 2.88
18 INT26705 Transcription of ADRA1D 6 0.67 3.99 2.74
19 INT263088 Positive_regulation of Mki67 15 0.19 2.13 2.57
20 INT65948 Binding of DNASE1L3 8 0.31 1.38 2.21
21 INT6521 Negative_regulation of Gene_expression of ADRA1D 4 0.57 3.19 2.14
22 INT57115 Negative_regulation of NT5E 8 0.57 4.35 2.03
23 INT131818 Binding of Parp1 14 0.46 8.74 1.76
24 INT99387 Positive_regulation of Negative_regulation of ADRA1D 1 0.07 0.54 1.74
25 INT63586 Regulation of Parp1 5 0.43 3.28 1.68
26 INT173754 Regulation of Mki67 4 0.06 1.04 1.61
27 INT6438 Positive_regulation of RAN 6 0.42 2.09 1.59
28 INT97053 Transcription of Parp1 3 0.66 2.04 1.43
29 INT189948 Gene_expression of Pttg1 106 0.76 104.68 1.41
30 INT96420 Positive_regulation of NT5E 9 0.49 3.7 1.38
31 INT155036 Localization of NT5E 6 0.73 4.1 1.35
32 INT26703 Positive_regulation of Transcription of ADRA1D 3 0.49 1.99 1.34
33 INT6520 Regulation of Gene_expression of ADRA1D 5 0.44 1.15 1.18
34 INT175508 Protein_catabolism of Parp1 30 0.85 30 1.09
35 INT123816 Positive_regulation of Gene_expression of Parp1 9 0.50 6.64 1.04
36 INT26881 Regulation of Binding of ADRA1D 3 0.44 1.05 0.94
37 INT263089 Positive_regulation of Gene_expression of Mki67 7 0.14 0.82 0.92
38 INT115845 Positive_regulation of Gene_expression of DNASE1L3 2 0.40 0.58 0.9
39 INT147616 Negative_regulation of Positive_regulation of Parp1 3 0.43 2.53 0.84
40 INT326044 Negative_regulation of Gene_expression of Mki67 2 0.12 0.08 0.83
41 INT17246 Negative_regulation of POLG 16 0.56 9.69 0.79
42 INT157610 Gene_expression of Parp1 4 0.58 2.16 0.77
43 INT291566 Localization of Mki67 2 0.13 0.7 0.77
44 INT287128 Protein_catabolism of NT5E 2 0.11 0.64 0.76
45 INT294133 Regulation of Gene_expression of NT5E 4 0.12 1.36 0.71
46 INT173749 Negative_regulation of Mki67 2 0.10 0.47 0.71
47 INT291567 Positive_regulation of Regulation of Mki67 1 0.03 0.6 0.68
48 INT155035 Binding of NT5E 3 0.36 1.78 0.61
49 INT123814 Positive_regulation of Positive_regulation of Parp1 9 0.50 9.32 0.57
50 INT56470 Regulation of MKI67 5 0.05 6.78 0.49
51 INT109867 Negative_regulation of Negative_regulation of Parp1 2 0.42 3.37 0.49
52 INT107676 Positive_regulation of Protein_catabolism of Parp1 1 0.10 0.91 0.48
53 INT61010 Negative_regulation of Regulation of ADRA1D 1 0.41 0 0.48
54 INT233013 Positive_regulation of Positive_regulation of Parp1 1 0.23 1.78 0.47
55 INT35592 Regulation of Regulation of ADRA1D 1 0.44 0 0.47
56 INT107675 Negative_regulation of Protein_catabolism of Parp1 1 0.08 0.91 0.47
57 INT107678 Protein_catabolism of Parp1 1 0.19 0.9 0.47
58 INT251661 Phosphorylation of NT5E 2 0.21 1.59 0.46
59 INT158837 Binding of POLG 4 0.37 4.69 0.44
60 INT157609 Regulation of Parp1 2 0.26 1.4 0.43
61 INT96419 Positive_regulation of Gene_expression of NT5E 3 0.49 1.46 0.41
62 INT189946 Positive_regulation of Gene_expression of Pttg1 14 0.68 23.72 0.38
63 INT9097 Positive_regulation of DNASE1L3 2 0.41 0.33 0.37
64 INT95655 Negative_regulation of Gene_expression of MKI67 5 0.41 3.66 0.36
65 INT19414 Positive_regulation of Localization of ADRA1D 2 0.49 0.89 0.35
66 INT186468 Positive_regulation of Protein_catabolism of Parp1 2 0.33 5.05 0.34
67 INT287690 Negative_regulation of Positive_regulation of Parp1 1 0.20 0.65 0.33
68 INT347561 Negative_regulation of Positive_regulation of Mki67 1 0.04 0 0.33
69 INT287129 Regulation of NT5E 3 0.12 1.02 0.32
70 INT118046 Regulation of RAN 2 0.34 0.14 0.29
71 INT157135 Positive_regulation of MKI67 10 0.60 7.51 0.28
72 INT44766 Negative_regulation of Binding of ADRA1D 2 0.42 0.71 0.27
73 INT127655 Localization of MKI67 6 0.73 3.72 0.26
74 INT287683 Regulation of Gene_expression of Parp1 1 0.21 0.64 0.26
75 INT39107 Positive_regulation of Binding of ADRA1D 1 0.49 0.52 0.25
76 INT138715 Gene_expression of POLG 12 0.66 6.97 0.23
77 INT294138 Positive_regulation of Localization of NT5E 1 0.14 0.41 0.21
78 INT294141 Regulation of Localization of NT5E 1 0.12 0.42 0.21
79 INT169619 Negative_regulation of RAN 1 0.28 0.2 0.21
80 INT207809 Positive_regulation of Negative_regulation of Parp1 2 0.50 1.01 0.2
81 INT169621 Gene_expression of RAN 1 0.44 0.18 0.19
82 INT93885 Positive_regulation of Gene_expression of MKI67 8 0.60 4.4 0.18
83 INT169582 Phosphorylation of POLG 2 0.54 1.98 0.18
84 INT102528 Regulation of Positive_regulation of ADRA1D 1 0.44 0.09 0.18
85 INT175532 Localization of Parp1 9 0.74 5.73 0.17
86 INT189945 Localization of Pttg1 3 0.73 3.02 0.16
87 INT250795 Negative_regulation of Gene_expression of Parp1 4 0.41 5.01 0.15
88 INT199856 Negative_regulation of Protein_catabolism of Parp1 2 0.41 1.46 0.15
89 INT236392 Regulation of Rad51 1 0.00 0.3 0.14
90 INT26455 Negative_regulation of Positive_regulation of ADRA1D 1 0.41 0.1 0.13
91 INT61502 Binding of Mki67 2 0.04 0.66 0.12
92 INT302679 Negative_regulation of Localization of POLG 1 0.39 0.99 0.11
93 INT186056 Binding of MKI67 6 0.48 4.44 0.1
94 INT302692 Localization of POLG 1 0.69 0.99 0.1
95 INT35610 Regulation of DNASE1L3 1 0.23 0.34 0.09
96 INT253175 Regulation of Positive_regulation of Parp1 2 0.52 0.97 0.08
97 INT24707 Protein_catabolism of ADRA1D 1 0.86 0.6 0.08
98 INT251829 Positive_regulation of POLG 1 0.53 1.5 0.08
99 INT268846 Negative_regulation of Top2a 6 0.29 3.06 0.07
100 INT175513 Positive_regulation of Localization of Parp1 2 0.23 2.23 0.07
101 INT282818 Negative_regulation of DNASE1L3 1 0.13 0.1 0.06
102 INT253176 Regulation of Gene_expression of Parp1 2 0.23 0.61 0.05
103 INT333807 Localization of Rad51 1 0.24 0.52 0.05
104 INT251827 Regulation of POLG 3 0.59 2.94 0.04
105 INT100664 Negative_regulation of MKI67 12 0.10 9.77 0
106 INT235686 Gene_expression of Top2a 5 0.60 4.34 0
107 INT189944 Negative_regulation of Gene_expression of Pttg1 4 0.42 4.53 0
108 INT189947 Regulation of Pttg1 4 0.49 7.18 0
109 INT100663 Regulation of Gene_expression of MKI67 3 0.39 0.36 0
110 INT201870 Phosphorylation of MKI67 2 0.06 1.4 0
111 INT268847 Binding of Top2a 2 0.24 0.6 0
112 INT189951 Binding of Pttg1 2 0.44 1.16 0
113 INT266162 Transcription of POLG 2 0.68 0.76 0
114 INT189943 Negative_regulation of Pttg1 2 0.53 5.8 0
115 INT252948 Positive_regulation of Protein_catabolism of Pttg1 1 0.63 0.09 0
116 INT252949 Negative_regulation of Negative_regulation of Pttg1 1 0.39 0.34 0
117 INT252967 Localization of PTTG2 1 0.34 0.1 0
118 INT213941 Transcription of MKI67 1 0.03 0.75 0
119 INT175530 Regulation of Protein_catabolism of Parp1 1 0.09 1.36 0
120 INT296158 Negative_regulation of Rad51 1 0.17 0.11 0
121 INT252995 Gene_expression of PTTG2 1 0.33 0.1 0
122 INT328418 Protein_catabolism of Dnase2b 1 0.42 0.72 0
123 INT266161 Regulation of Negative_regulation of POLG 1 0.38 0.56 0
124 INT252952 Protein_catabolism of Pttg1 1 0.91 0.09 0
125 INT256916 Regulation of Gene_expression of Top2a 1 0.47 1.2 0
126 INT213943 Regulation of Transcription of MKI67 1 0.01 0.75 0
127 INT266164 Negative_regulation of Gene_expression of POLG 1 0.41 1.08 0
128 INT252944 Positive_regulation of Pttg1 1 0.46 2.53 0
129 INT252938 Phosphorylation of Pttg1 1 0.75 1.11 0
130 INT252972 Negative_regulation of Gene_expression of PTTG2 1 0.18 0.1 0
131 INT304335 Positive_regulation of Positive_regulation of Mki67 1 0.04 0 0
132 INT292884 Positive_regulation of Binding of MKI67 1 0.06 0.52 0
133 INT213942 Regulation of Positive_regulation of MKI67 1 0.01 0.63 0
134 INT266170 Negative_regulation of Transcription of POLG 1 0.36 1.43 0
135 INT252957 Regulation of Binding of Pttg1 1 0.41 0.64 0
136 INT251832 Positive_regulation of Positive_regulation of POLG 1 0.35 0.28 0
137 INT189950 Transcription of Pttg1 1 0.70 2.38 0
138 INT256921 Regulation of Top2a 1 0.21 1.28 0
139 INT252958 Positive_regulation of Localization of Pttg1 1 0.37 0 0
140 INT189949 Regulation of Gene_expression of Pttg1 1 0.60 6.84 0
141 INT207802 Regulation of Localization of Parp1 1 0.45 0.35 0
142 INT304337 Regulation of Positive_regulation of Mki67 1 0.02 0 0
143 INT136610 Binding of RAN 1 0.35 0.09 0
144 INT250717 Negative_regulation of Phosphorylation of MKI67 1 0.03 1.33 0
145 INT213936 Negative_regulation of Positive_regulation of MKI67 1 0.02 0.8 0
146 INT268845 Positive_regulation of Binding of Top2a 1 0.05 0.33 0
147 INT252978 Gene_expression of PTTG3P 1 0.28 0.09 0
148 INT118047 Regulation of Positive_regulation of RAN 1 0.07 0 0
149 INT273508 Negative_regulation of Gene_expression of Top2a 1 0.21 0.17 0
150 INT191212 Gene_expression of RECQL5 1 0.63 0.17 0
151 INT296159 Gene_expression of Rad51 1 0.11 0.11 0
152 INT329193 Regulation of Binding of NT5E 1 0.07 0.67 0
153 INT252946 Negative_regulation of Binding of Pttg1 1 0.34 0.29 0
154 INT282819 Localization of DNASE1L3 1 0.24 0 0
155 INT252955 Positive_regulation of Negative_regulation of Pttg1 1 0.40 1.1 0
156 INT183617 Protein_catabolism of MKI67 1 0.26 0.07 0
157 INT171768 Transcription of DNASE1L3 1 0.04 0 0
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