GO:0006275

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Name regulation of DNA replication
Categary Process
Go Slim No
Go Link GO:0006275
Unique Molecular Interactions 63
Total Molecular Interactions 94
Total Single Events 707
Pain Genes Associated 8

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for regulation of DNA replication. They are ordered first by their pain relevance and then by number of times they were reported for regulation of DNA replication. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT113844 CDKN1A Negative_regulation of CDK2 4 0.49 1.18 1.27
2 INT225158 Binding of CDK2 and CDKN1A 7 0.30 3.26 1.02
3 INT164265 TGM7 Negative_regulation of CDK2 1 0.26 1.08 0.53
4 INT177504 Gabrg1 Positive_regulation of PCNA 1 0.07 0.22 0.52
5 INT135755 Pomc Positive_regulation of Positive_regulation of Id3 1 0.17 0 0.5
6 INT135752 Pomc Positive_regulation of Id3 1 0.16 0 0.5
7 INT225160 Negative_regulation of Binding of CDK2 and CDKN1A 1 0.35 0 0.25
8 INT88410 BMP7 Negative_regulation of CDK2 1 0.35 0 0.14
9 INT184953 Binding of CDC6 and PCNA 1 0.05 0.19 0.13
10 INT129623 Bmp7 Positive_regulation of Gene_expression of Id3 1 0.37 0.31 0.08
11 INT129622 Id3 Positive_regulation of Gene_expression of Bmp7 1 0.25 0.31 0.08
12 INT166785 NSMAF Negative_regulation of Gene_expression of PCNA 1 0.30 1.26 0.08
13 INT88411 Positive_regulation of PDGFA Positive_regulation of CDK2 1 0.11 0 0.07
14 INT258021 Positive_regulation of Binding of CDK2 and CDKN1A 1 0.11 0.84 0.07
15 INT129626 Bmp7 Positive_regulation of Id3 1 0.25 0.25 0.07
16 INT88408 PDGFA Positive_regulation of CDK2 1 0.11 0 0.07
17 INT176224 Binding of CDKN1A and PCNA 4 0.08 2.52 0.03
18 INT326051 Csf2 Positive_regulation of PCNA 1 0.04 0.17 0.03
19 INT176286 Fasl Positive_regulation of Gene_expression of Pcna 1 0.02 0.81 0.03
20 INT326052 Epo Positive_regulation of PCNA 1 0.04 0.17 0.03
21 INT289608 Binding of CDK2 and CCNE2 5 0.06 4.89 0
22 INT219412 CDK2 Regulation of PCNA 1 0.20 0.11 0
23 INT253003 Pttg1 Regulation of Gene_expression of Id3 1 0.08 0.07 0
24 INT275231 Binding of ACVRL1 and AK3 1 0.01 0.72 0
25 INT269932 Pcna Negative_regulation of Cdkn2b 1 0.09 0.07 0
26 INT330697 PCNA Regulation of INCENP 1 0.00 0.3 0
27 INT326017 Binding of PCNA and HCC 1 0.00 0.99 0
28 INT214902 Binding of Pcna and Trib3 1 0.00 1.51 0
29 INT219405 CCNF Regulation of PCNA 1 0.20 0.11 0
30 INT325156 CDKN1B Negative_regulation of CDK2 1 0.49 0.11 0
31 INT176289 Pcna Positive_regulation of Phosphorylation of Esr1 1 0.01 0.67 0
32 INT219417 CCNA2 Regulation of PCNA 1 0.10 0.11 0
33 INT218976 Dlst Positive_regulation of Gene_expression of PCNA 1 0.05 0.06 0
34 INT176288 Binding of Cdk2 and Pcna 1 0.01 0.66 0
35 INT269926 Cdkn2b Negative_regulation of Pcna 1 0.08 0.07 0
36 INT219426 CDK2 Regulation of HNF4A 1 0.01 0.11 0
37 INT330698 PCNA Regulation of RB1 1 0.00 0.3 0
38 INT176291 Fasl Regulation of Gene_expression of Pcna 1 0.01 0.31 0
39 INT338970 Binding of ING1 and PCNA 1 0.11 0.98 0
40 INT315169 Egfr Negative_regulation of PCNA 1 0.03 0.84 0
41 INT253008 PTTG1 Regulation of Gene_expression of Id3 1 0.03 0.2 0
42 INT219407 Binding of ESR1 and PCNA 1 0.31 0.31 0
43 INT314688 Binding of CCNE1 and CDK2 1 0.04 1.41 0
44 INT253016 Binding of PTTG1 and Id3 1 0.04 0.07 0
45 INT315170 Erbb2 Negative_regulation of PCNA 1 0.03 0.84 0
46 INT219413 CDK2 Regulation of SKP2 1 0.23 0.11 0
47 INT188272 Binding of KITLG and PCNA 1 0.01 0.17 0
48 INT238394 Binding of PCNA and SRA1 1 0.00 0.07 0
49 INT269914 Tpt1 Negative_regulation of Pcna 1 0.08 0.07 0
50 INT176290 Fasl Positive_regulation of Pcna 1 0.02 0.44 0
51 INT271096 Pcna Positive_regulation of Akt1 1 0.00 0.34 0
52 INT176282 Binding of Pcna and p53-ps 1 0.00 0.69 0
53 INT219422 CCNE2 Regulation of PCNA 1 0.10 0.11 0
54 INT322544 Binding of CDK2 and Ccne1 1 0.16 0 0
55 INT322503 Negative_regulation of Binding of CDK2 and CCNE2 1 0.01 0.25 0
56 INT269952 Pcna Negative_regulation of Tpt1 1 0.09 0.07 0
57 INT286109 Binding of Pcna and Mutyh 1 0.30 0 0
58 INT238391 ELANE Positive_regulation of PCNA 1 0.01 0.07 0
59 INT177783 Binding of HDAC1 and PCNA 1 0.09 0.5 0
60 INT269916 Sox17 Positive_regulation of Pcna 1 0.16 0 0
61 INT342439 PPP2CA Negative_regulation of PRMT1 1 0.12 0.63 0
62 INT219419 CDK2 Regulation of E2F2 1 0.23 0.11 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for regulation of DNA replication. They are ordered first by their pain relevance and then by number of times they were reported in regulation of DNA replication. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT56749 Gene_expression of PCNA 219 0.77 111.25 18.42
2 INT88414 Negative_regulation of CDK2 30 0.57 18.4 3.96
3 INT86369 Positive_regulation of Gene_expression of PCNA 40 0.67 26.66 3.57
4 INT85078 Positive_regulation of PCNA 36 0.49 17.06 2.81
5 INT50558 Negative_regulation of PCNA 31 0.57 13.97 2.3
6 INT101572 Negative_regulation of Gene_expression of PCNA 24 0.53 13.87 2.21
7 INT112868 Gene_expression of Pcna 21 0.75 8.6 2.15
8 INT68952 Localization of PCNA 17 0.62 5.64 1.78
9 INT88412 Positive_regulation of CDK2 17 0.57 8.49 1.66
10 INT61643 Gene_expression of ACVRL1 9 0.51 9.04 1.03
11 INT106735 Phosphorylation of CDK2 11 0.79 4.03 1.02
12 INT61642 Binding of ACVRL1 5 0.31 7.03 0.87
13 INT111485 Gene_expression of Pcna 2 0.75 0 0.83
14 INT66992 Positive_regulation of Id3 2 0.43 0.23 0.78
15 INT105330 Gene_expression of CDK2 31 0.63 13.7 0.67
16 INT113846 Negative_regulation of Positive_regulation of CDK2 1 0.48 0.39 0.6
17 INT169957 Transcription of PCNA 7 0.34 0.94 0.55
18 INT111484 Positive_regulation of Gene_expression of Pcna 1 0.67 0 0.54
19 INT176264 Binding of PCNA 21 0.21 9.08 0.51
20 INT135747 Gene_expression of Id3 1 0.52 0 0.5
21 INT163285 Negative_regulation of Phosphorylation of CDK2 2 0.32 0.52 0.48
22 INT241674 Negative_regulation of Transcription of PCNA 1 0.11 0.33 0.47
23 INT139399 Regulation of Gene_expression of PCNA 14 0.56 6.06 0.43
24 INT101568 Negative_regulation of Pcna 1 0.41 5.24 0.42
25 INT129621 Gene_expression of Id3 5 0.75 2.3 0.36
26 INT139391 Regulation of PCNA 10 0.60 3.12 0.33
27 INT118955 Phosphorylation of PCNA 4 0.29 1.54 0.33
28 INT139741 Positive_regulation of Gene_expression of ACVRL1 2 0.38 1.33 0.28
29 INT106733 Regulation of CDK2 6 0.44 4.76 0.23
30 INT216124 Negative_regulation of Pcna 3 0.13 2.06 0.19
31 INT163284 Negative_regulation of Gene_expression of CDK2 5 0.32 1.6 0.16
32 INT189590 Positive_regulation of ACVRL1 3 0.08 1.3 0.16
33 INT200943 Negative_regulation of PPP2CA 1 0.10 0.13 0.14
34 INT238422 Positive_regulation of Positive_regulation of PCNA 4 0.20 2.92 0.13
35 INT256849 Regulation of Pcna 1 0.05 0.3 0.13
36 INT201462 Binding of CDK2 12 0.39 5.2 0.12
37 INT125588 Positive_regulation of Gene_expression of Pcna 5 0.49 1.57 0.11
38 INT201460 Positive_regulation of Gene_expression of CDK2 5 0.52 2.8 0.09
39 INT169428 Regulation of Gene_expression of CDK2 4 0.46 1.03 0.09
40 INT106732 Regulation of Phosphorylation of CDK2 2 0.44 0.8 0.09
41 INT302272 Localization of CDK2 2 0.30 1.09 0.09
42 INT129611 Positive_regulation of Id3 1 0.49 0.31 0.08
43 INT129617 Positive_regulation of Positive_regulation of Id3 1 0.49 0.31 0.08
44 INT129618 Positive_regulation of Gene_expression of Id3 1 0.39 0.31 0.08
45 INT129609 Regulation of Gene_expression of Id3 1 0.44 0.3 0.06
46 INT269893 Negative_regulation of Gene_expression of Pcna 2 0.18 0.86 0.04
47 INT273404 Positive_regulation of Localization of PCNA 2 0.36 0.09 0.03
48 INT201468 Negative_regulation of Binding of CDK2 2 0.17 1.1 0.03
49 INT306289 Regulation of Positive_regulation of PCNA 1 0.06 0.07 0.03
50 INT176239 Regulation of Gene_expression of Pcna 1 0.04 0.58 0.03
51 INT176250 Positive_regulation of Pcna 6 0.13 3.52 0
52 INT169427 Transcription of CDK2 2 0.09 0.42 0
53 INT169956 Positive_regulation of Transcription of PCNA 2 0.10 0.09 0
54 INT201643 Binding of Pcna 2 0.36 0 0
55 INT238425 Negative_regulation of Positive_regulation of PCNA 2 0.05 1.39 0
56 INT285901 Regulation of Transcription of CDK2 1 0.03 0.7 0
57 INT189611 Negative_regulation of Gene_expression of ACVRL1 1 0.06 0.29 0
58 INT341855 Positive_regulation of Positive_regulation of CDK2 1 0.06 0.51 0
59 INT271087 Phosphorylation of Pcna 1 0.01 0.65 0
60 INT342452 Gene_expression of PPP2CA 1 0.20 0.49 0
61 INT114219 Positive_regulation of Pcna 1 0.06 0.45 0
62 INT201631 Localization of Pcna 1 0.01 0.5 0
63 INT289620 Regulation of Binding of CDK2 1 0.28 0.22 0
64 INT297259 Regulation of ACVRL1 1 0.18 0.55 0
65 INT176244 Regulation of Pcna 1 0.02 0.31 0
66 INT342450 Positive_regulation of PPP2CA 1 0.15 1.07 0
67 INT325169 Regulation of Negative_regulation of CDK2 1 0.34 0.05 0
68 INT225187 Positive_regulation of Binding of CDK2 1 0.56 0.87 0
69 INT252988 Negative_regulation of Binding of PCNA 1 0.06 1.25 0
70 INT288825 Positive_regulation of Binding of PCNA 1 0.06 1.29 0
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