GO:0006302

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Name double-strand break repair
Categary Process
Go Slim No
Go Link GO:0006302
Unique Molecular Interactions 464
Total Molecular Interactions 599
Total Single Events 4347
Pain Genes Associated 42

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for double-strand break repair. They are ordered first by their pain relevance and then by number of times they were reported for double-strand break repair. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT206768 TP53 Positive_regulation of Ltp 2 0.01 5.83 10.21
2 INT42579 SOD1 Negative_regulation of POMC 1 0.16 0.43 1.27
3 INT130232 Binding of Cat and Sod1 1 0.35 0.3 0.98
4 INT130231 Positive_regulation of Binding of Cat and Sod1 1 0.46 0.3 0.98
5 INT73461 PTPLA Positive_regulation of Transcription of TP53 1 0.06 0.99 0.96
6 INT330629 TP53 Negative_regulation of Gene_expression of Fos 1 0.30 1.76 0.94
7 INT330630 Binding of TP53 and Car1 1 0.23 1.56 0.86
8 INT97057 Bcl2l1 Regulation of Gene_expression of Trp53 1 0.36 0.51 0.83
9 INT97058 Cpz Regulation of Gene_expression of Trp53 1 0.27 0.57 0.83
10 INT322266 Binding of LIG4 and NOS3 1 0.02 2.35 0.82
11 INT117412 RYBP Negative_regulation of LIG4 1 0.00 0.42 0.76
12 INT250959 Binding of HLA-B and SOD1 1 0.05 0.75 0.75
13 INT251729 Binding of FEN1 and EXOSC1 1 0.19 1.13 0.74
14 INT296097 Acsm3 Negative_regulation of SOD1 1 0.01 1.3 0.72
15 INT106601 ZNF398 Negative_regulation of Protein_catabolism of CIB1 1 0.02 0.21 0.7
16 INT101986 TP53 Positive_regulation of Gene_expression of GDF15 1 0.52 2.45 0.67
17 INT166402 CDKN1A Regulation of Gene_expression of TP53 1 0.27 0.83 0.61
18 INT160779 Cps1 Positive_regulation of ATM 1 0.01 0.94 0.53
19 INT254200 Mif Regulation of Trp53 1 0.02 0.96 0.52
20 INT274625 OPN1MW Positive_regulation of SOD1 1 0.19 0.29 0.5
21 INT322048 Prkdc Negative_regulation of Col7a1 1 0.00 0.45 0.5
22 INT132060 NBN Positive_regulation of Nos2 1 0.01 0.21 0.49
23 INT58578 Binding of RPA1 and TACR1 1 0.01 0 0.48
24 INT241914 SOD1 Positive_regulation of Ros1 1 0.00 0.76 0.44
25 INT302829 Mapkapk5 Positive_regulation of Trp53 1 0.07 0.81 0.43
26 INT250956 Positive_regulation of Binding of HLA-B and SOD1 1 0.07 0.38 0.38
27 INT353454 Binding of BRCA1 and IL17A 1 0.00 2.55 0.36
28 INT353452 Binding of AGRP and BRCA1 1 0.00 3.89 0.34
29 INT91814 Binding of TNF and TP53 1 0.14 2.2 0.32
30 INT166394 CDKN1B Regulation of Gene_expression of TP53 1 0.28 0.41 0.31
31 INT166396 IFI27 Regulation of Gene_expression of TP53 1 0.19 0.41 0.31
32 INT333917 MDM2 Positive_regulation of Protein_catabolism of Trp53 1 0.01 1.23 0.3
33 INT333918 HDAC1 Regulation of Trp53 1 0.03 1.24 0.3
34 INT56250 Binding of NBN and NCOR2 1 0.00 0 0.3
35 INT163761 MDM2 Positive_regulation of Gene_expression of TP53 1 0.40 0.86 0.3
36 INT166952 LYRM4 Positive_regulation of Gene_expression of TP53 1 0.05 0.75 0.28
37 INT286042 Binding of Tp53 and Wwox 1 0.04 2.05 0.28
38 INT216127 EGR1 Regulation of Transcription of TP53 1 0.06 0.21 0.28
39 INT302837 Binding of TNFRSF10D and Trp53 1 0.01 0.98 0.28
40 INT306267 Binding of INCENP and TP53 1 0.02 0.83 0.27
41 INT216128 EGR1 Regulation of TP53 1 0.11 0.21 0.27
42 INT352931 Prkaca Regulation of TP53 1 0.13 1.01 0.26
43 INT353448 BRCA1 Positive_regulation of CCL2 1 0.01 1.37 0.26
44 INT352930 Prkaca Regulation of Phosphorylation of TP53 1 0.13 1.02 0.26
45 INT125514 Positive_regulation of PRKDC Positive_regulation of Positive_regulation of NFKB1 1 0.07 0.44 0.26
46 INT353449 BRCA1 Positive_regulation of IL4 1 0.00 1.37 0.26
47 INT182325 TP53 Negative_regulation of Transcription of Birc5 1 0.01 1.34 0.26
48 INT353455 BRCA1 Positive_regulation of IL13 1 0.00 1.37 0.26
49 INT172975 Trp53 Positive_regulation of Cdkn1a 1 0.03 1.35 0.26
50 INT352893 PTGDS Regulation of TP53 1 0.16 1.02 0.26
51 INT125516 TP53 Regulation of GDF15 1 0.10 0.47 0.26
52 INT220635 Binding of Lrp1 and Kat5 2 0.09 0.71 0.25
53 INT337086 Mif Negative_regulation of Localization of Trp53 1 0.16 1.64 0.25
54 INT337091 Mif Negative_regulation of Positive_regulation of Trp53 1 0.16 1.64 0.25
55 INT198926 Binding of Apbb1 and Lrp1 5 0.12 2.18 0.24
56 INT156879 Gene_expression of TP53 Negative_regulation of Positive_regulation of PDF 1 0.45 0.9 0.24
57 INT181900 TP53 Negative_regulation of Gene_expression of NOS1 1 0.03 0.94 0.24
58 INT156881 TP53 Positive_regulation of Positive_regulation of PDF 1 0.49 0.89 0.24
59 INT229177 IFRD1 Regulation of TP53 1 0.13 0.68 0.23
60 INT226902 Padi3 Regulation of Trp53 1 0.06 0.69 0.22
61 INT229178 TP53 Regulation of ICAM1 1 0.07 0.9 0.21
62 INT182606 Binding of MSH2 and MSH3 1 0.12 1.4 0.21
63 INT309513 Binding of Xrcc6 and Htt 1 0.30 3.69 0.21
64 INT322017 RPA1 Positive_regulation of IL1B 1 0.00 0 0.21
65 INT156882 Binding of TP53 and PDF 1 0.39 0.77 0.21
66 INT156880 TP53 Positive_regulation of Gene_expression of PDF 1 0.49 0.75 0.21
67 INT305508 Binding of Sod1 and Slc17a6 1 0.03 1.1 0.2
68 INT132054 NBN Positive_regulation of NOS1 1 0.00 0.08 0.2
69 INT210887 Sst Positive_regulation of Gene_expression of Trp53 1 0.33 0.93 0.2
70 INT305511 Negative_regulation of Binding of Sod1 and Slc17a6 1 0.03 1.1 0.2
71 INT68510 Binding of ATM and PRLR 1 0.01 0 0.19
72 INT28562 SOD1 Negative_regulation of Pacs1 1 0.03 2.63 0.19
73 INT91862 RPA1 Negative_regulation of Transcription of ATG9B 1 0.03 0.46 0.19
74 INT193787 Positive_regulation of CXCR4 Positive_regulation of Positive_regulation of TP53 1 0.03 0.71 0.19
75 INT142853 Binding of TP53 and WISP2 1 0.33 1.43 0.19
76 INT251492 Binding of HSPD1 and SOD1 1 0.02 1.45 0.18
77 INT250949 Binding of KIR3DL2 and SOD1 1 0.24 0.55 0.18
78 INT179158 ATM Regulation of Gene_expression of GOPC 1 0.01 0 0.18
79 INT58579 Binding of INSRR and RPA1 1 0.00 0 0.18
80 INT179163 ATM Regulation of Gene_expression of IL13 1 0.01 0 0.18
81 INT179161 ATM Regulation of Gene_expression of IL6 1 0.02 0 0.18
82 INT179162 ATM Regulation of Gene_expression of IL8 1 0.01 0 0.18
83 INT102804 NFKB1 Regulation of TP53 1 0.35 0.77 0.17
84 INT102803 NFKB1 Regulation of Gene_expression of TP53 1 0.35 0.77 0.17
85 INT91812 Binding of FASLG and TP53 1 0.04 1.1 0.16
86 INT91811 Binding of FAS and TP53 1 0.21 1.1 0.16
87 INT266377 Binding of S100a11 and Trp53 1 0.02 0.89 0.15
88 INT311666 Binding of BCL2 and TP53 1 0.19 1.26 0.14
89 INT353451 Binding of BRCA1 and CRP 1 0.01 1.18 0.14
90 INT29207 Msh2 Regulation of POMC 1 0.02 0.1 0.14
91 INT252575 Rpe Negative_regulation of SOD1 1 0.03 2.39 0.14
92 INT240909 Hmgcr Regulation of Gene_expression of Sod1 1 0.03 0.53 0.14
93 INT353453 Binding of BRCA1 and IL4 1 0.00 1.18 0.14
94 INT103557 Binding of ERCC2 and TP53 1 0.40 1 0.13
95 INT132148 LTF Positive_regulation of TP53 1 0.44 0.56 0.13
96 INT153740 TNFRSF11A Positive_regulation of Vcp 1 0.04 1.15 0.13
97 INT103561 Binding of TP53 and Mc1r 1 0.03 1 0.13
98 INT342311 Binding of Tp53 and Positive_regulation of Gene_expression of BCL2 1 0.08 1.25 0.13
99 INT220639 Binding of Apbb1 and Ighd 1 0.12 0.31 0.12
100 INT220633 Binding of Kat5 and Ighd 1 0.09 0.32 0.12
101 INT83370 Binding of HRAS and TP53 1 0.30 0.59 0.11
102 INT350736 PRKDC Negative_regulation of CA2 1 0.02 0.16 0.11
103 INT350735 PRKDC Negative_regulation of ITPR3 1 0.01 0.16 0.11
104 INT266900 Gene_expression of Sod2 Negative_regulation of Gene_expression of Sod1 1 0.11 0.41 0.11
105 INT266386 Binding of S100a1 and Trp53 1 0.03 0.64 0.1
106 INT193782 Binding of TP53 and SDF2L1 1 0.00 0.67 0.1
107 INT262522 Binding of Trp53 and Foxo4 1 0.05 0.7 0.1
108 INT303815 Binding of Igfals and Tdp1 1 0.11 1.68 0.1
109 INT310743 TP53 Regulation of BAX 1 0.09 1.11 0.1
110 INT326126 Binding of S100A1 and TP53 1 0.04 1.34 0.09
111 INT352611 Trp53 Negative_regulation of Localization of Gli1 1 0.23 1.2 0.09
112 INT302168 YWHAQ Regulation of TP53 1 0.01 0.41 0.09
113 INT265466 CSPG4 Regulation of Phosphorylation of TP53 1 0.09 0.15 0.09
114 INT174133 Binding of Igfals and Sod1 3 0.19 3 0.08
115 INT246625 Sirt1 Positive_regulation of Negative_regulation of Trp53 1 0.10 0.96 0.08
116 INT303337 Binding of SOD1 and Igfals 1 0.06 1.27 0.08
117 INT346695 Negative_regulation of SOD1 Positive_regulation of Negative_regulation of Hist3h2a 1 0.00 0.41 0.08
118 INT188007 NLRP3 Regulation of Binding of TP53BP1 1 0.28 0.62 0.08
119 INT309511 Binding of Xrcc6 and Xrcc5 1 0.18 1.18 0.08
120 INT273520 NBN Positive_regulation of CDIPT 1 0.06 0.82 0.08
121 INT266394 Binding of S100a4 and Trp53 1 0.03 0.59 0.08
122 INT31986 NTS Positive_regulation of Binding of SOD1 1 0.16 0 0.08
123 INT266390 Binding of S100a6 and Trp53 1 0.04 0.51 0.07
124 INT245296 Trp53 Regulation of Gadd45a 1 0.05 0.43 0.07
125 INT266398 Binding of S100b and Trp53 1 0.06 0.92 0.07
126 INT220724 Binding of IGFALS and SOD1 1 0.06 2.1 0.06
127 INT302143 TP53 Regulation of Positive_regulation of CASP3 1 0.01 0.69 0.06
128 INT302155 TP53 Regulation of Positive_regulation of CASP9 1 0.02 0.7 0.06
129 INT204074 Tp53 Positive_regulation of Cdkn1b 1 0.00 0.59 0.06
130 INT140291 ROS1 Positive_regulation of TP53 1 0.52 1.27 0.06
131 INT190044 Binding of Msh2 and Msh6 2 0.32 0.77 0.05
132 INT262233 Nr1i2 Negative_regulation of SOD1 1 0.03 0.23 0.05
133 INT265459 Phosphorylation of TP53 Positive_regulation of Localization of CASP9 1 0.17 1.16 0.05
134 INT353450 Binding of BRCA1 and VEGFA 1 0.01 0.82 0.05
135 INT352618 Tpt1 Regulation of Trp53 1 0.06 0.54 0.05
136 INT286768 Binding of Trp53 and Tusc2 1 0.07 1.1 0.05
137 INT237085 Binding of Bnip3l and Vcp 1 0.31 3.53 0.05
138 INT352621 Gli1 Negative_regulation of Trp53 1 0.32 0.56 0.05
139 INT249201 PRKDC Regulation of Regulation of CYBB 1 0.01 0.09 0.05
140 INT181601 Binding of TP53 and WT1 1 0.30 0.9 0.05
141 INT265454 Phosphorylation of TP53 Positive_regulation of CASP9 1 0.17 1.16 0.05
142 INT345181 Gpr87 Regulation of Trp53 1 0.01 0.42 0.05
143 INT193788 ITIH4 Regulation of Phosphorylation of TP53 1 0.07 0.45 0.05
144 INT262230 SOD1 Regulation of Nr1i2 1 0.02 0.3 0.05
145 INT190050 Binding of Msh2 and Pms2 2 0.32 0.49 0.04
146 INT352612 Trp53 Negative_regulation of Cd44 1 0.24 1.01 0.04
147 INT352669 PRKDC Positive_regulation of Memor1 1 0.00 1.02 0.04
148 INT240888 Sod1 Regulation of Gene_expression of Ins1 1 0.08 0.18 0.04
149 INT188006 NLRP3 Regulation of Gene_expression of TP53BP1 1 0.28 0.36 0.04
150 INT348022 Binding of Jun and Trp53 1 0.07 0.46 0.04
151 INT172214 BAX Positive_regulation of TP53 1 0.09 0.37 0.04
152 INT329230 Negative_regulation of ATIC Positive_regulation of Trp53 1 0.00 0.58 0.04
153 INT266897 Nfe2l2 Positive_regulation of Sod1 1 0.11 0.19 0.04
154 INT329228 ATIC Positive_regulation of Trp53 1 0.01 0.58 0.04
155 INT352619 Bcl2l12 Negative_regulation of Trp53 1 0.27 0.94 0.04
156 INT347416 Tlr4 Negative_regulation of SOD1 1 0.00 0.36 0.04
157 INT352613 Binding of Trp53 and Bcl2l12 1 0.23 0.94 0.04
158 INT188005 NLRP3 Regulation of TP53BP1 1 0.34 0.3 0.04
159 INT170457 RASGRP1 Regulation of TP53 1 0.02 0.58 0.04
160 INT201726 Mapk8 Positive_regulation of Positive_regulation of Trp53 1 0.00 0.41 0.04
161 INT260267 Binding of TFAM and TP53 2 0.37 2.1 0.03
162 INT240905 Gene_expression of Sod1 Negative_regulation of Phosphorylation of Creb1 1 0.32 0.1 0.03
163 INT355036 CKAP4 Regulation of Positive_regulation of TP53 1 0.08 0.4 0.03
164 INT240881 Gene_expression of Sod1 Positive_regulation of Phosphorylation of Foxo1 1 0.38 0.07 0.03
165 INT292416 SOD1 Regulation of Cat 1 0.01 0.45 0.03
166 INT266903 Binding of Sod2 and Trp53 1 0.05 0 0.03
167 INT211873 TP53 Positive_regulation of Transcription of CD40 1 0.03 1.44 0.03
168 INT234625 TP53 Positive_regulation of IGFBP3 1 0.29 0.74 0.03
169 INT352624 Trp53 Negative_regulation of CEL 1 0.01 1.01 0.03
170 INT265464 CSPG4 Regulation of Gene_expression of TP53 1 0.09 0.23 0.03
171 INT240875 Gene_expression of Sod1 Negative_regulation of Gene_expression of Pck1 1 0.33 0.27 0.03
172 INT314686 TP53 Regulation of Gene_expression of MDM2 1 0.21 0.96 0.03
173 INT229098 Binding of TP53 and IER3 1 0.01 1.47 0.03
174 INT314677 TP53 Regulation of Positive_regulation of CDKN2A 1 0.27 0.97 0.03
175 INT276389 Binding of Trp53 and KRT20 1 0.01 0.97 0.03
176 INT302134 TP53 Positive_regulation of Transcription of CDKN1A 1 0.04 0.28 0.03
177 INT314690 TP53 Regulation of Gene_expression of ZBTB7A 1 0.33 0.97 0.03
178 INT273519 NBN Negative_regulation of YOD1 1 0.03 0.56 0.03
179 INT221262 Binding of BRCA1 and CD4 1 0.22 0.81 0.03
180 INT240876 Gene_expression of Sod1 Negative_regulation of Pck1 1 0.33 0.27 0.03
181 INT211872 TP53 Positive_regulation of CD40 1 0.03 1.44 0.03
182 INT242015 Binding of Mdm2 and Trp53 3 0.16 5.74 0
183 INT290556 Binding of MLH1 and MSH2 3 0.34 2.74 0
184 INT234178 Binding of BRCA1 and BRCA2 2 0.40 1.52 0
185 INT239181 Gene_expression of Gh Negative_regulation of Sod1 1 0.24 0.33 0
186 INT313597 Binding of BRCA2 and TOX3 1 0.11 0.7 0
187 INT352615 Binding of Mdm4 and Trp53 1 0.30 1.36 0
188 INT356117 Binding of SORL1 and Apbb1 1 0.14 0.43 0
189 INT304029 Binding of PTEN and TP53 1 0.35 0.62 0
190 INT315395 Regulation of Binding of IFNA1 and Tp53 1 0.00 0.46 0
191 INT57107 Binding of Msh2 and Nts 1 0.22 0.22 0
192 INT304020 AR Regulation of TP53 1 0.24 1.11 0
193 INT315221 Tpt1 Regulation of Positive_regulation of Trp53 1 0.33 1.04 0
194 INT203901 HIVEP1 Positive_regulation of Gene_expression of TP53 1 0.04 0.86 0
195 INT329340 UCN2 Positive_regulation of SOD1 1 0.02 1.12 0
196 INT306511 Binding of XRCC6 and Ung 1 0.00 0.78 0
197 INT279704 Binding of CIB1 and Positive_regulation of ITPR3 1 0.06 0.17 0
198 INT232006 Binding of Trp53 and Tsp1 1 0.06 0.75 0
199 INT333853 Binding of SOD1 and Gtf3a 1 0.00 0 0
200 INT314742 Binding of RAD51 and Brca2 1 0.06 1.05 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for double-strand break repair. They are ordered first by their pain relevance and then by number of times they were reported in double-strand break repair. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT28361 Gene_expression of TP53 443 0.78 384.86 28.8
2 INT65856 Positive_regulation of TP53 138 0.67 112.65 16.71
3 INT93361 Gene_expression of Trp53 208 0.78 175.35 16.65
4 INT80972 Gene_expression of Tp53 104 0.78 102.74 16.02
5 INT31990 Positive_regulation of SOD1 124 0.69 67.79 12.52
6 INT14510 Gene_expression of SOD1 208 0.76 88.56 12.4
7 INT169997 Positive_regulation of Gene_expression of Tp53 37 0.70 47.3 9.85
8 INT67037 Gene_expression of Sod1 121 0.78 59.32 7.99
9 INT57748 Positive_regulation of Gene_expression of TP53 85 0.69 79.55 7.49
10 INT97055 Positive_regulation of Gene_expression of Trp53 51 0.70 45.7 7.25
11 INT14903 Negative_regulation of SOD1 81 0.57 42.02 6.91
12 INT93359 Positive_regulation of Trp53 90 0.70 69.77 6.24
13 INT112545 Phosphorylation of TP53 28 0.80 14.13 5.93
14 INT60585 Regulation of TP53 59 0.59 54.55 5.21
15 INT137332 Positive_regulation of Gene_expression of Sod1 41 0.70 19.8 4.69
16 INT109972 Phosphorylation of Trp53 13 0.80 6.15 4.68
17 INT62684 Negative_regulation of TP53 66 0.58 66.09 4.62
18 INT57749 Negative_regulation of Gene_expression of TP53 39 0.56 36.79 4.45
19 INT26404 Positive_regulation of ATM 15 0.49 10.94 4.39
20 INT119063 Gene_expression of BRCA1 24 0.67 30.04 4.17
21 INT71602 Negative_regulation of Trp53 84 0.59 67.77 3.68
22 INT106618 Positive_regulation of CIB1 9 0.63 3.38 3.63
23 INT8103 Binding of TP53 46 0.44 40.2 2.96
24 INT221269 Binding of BRCA1 14 0.40 31.77 2.7
25 INT109969 Positive_regulation of Phosphorylation of Trp53 1 0.45 2.18 2.66
26 INT91899 Binding of Sod1 17 0.47 11.56 2.63
27 INT31989 Binding of SOD1 43 0.47 19.38 2.55
28 INT303796 Gene_expression of Tdp1 1 0.77 70.15 2.55
29 INT109968 Positive_regulation of Positive_regulation of Trp53 6 0.47 3.57 2.51
30 INT55952 Transcription of TP53 16 0.61 12.14 2.36
31 INT108148 Positive_regulation of Prkdc 2 0.16 0.49 2.31
32 INT130230 Positive_regulation of Sod1 3 0.67 1.63 2.3
33 INT117415 Negative_regulation of LIG4 4 0.04 1.59 2.17
34 INT96764 Positive_regulation of Gene_expression of SOD1 36 0.61 16.55 1.99
35 INT125080 Positive_regulation of Positive_regulation of TP53 21 0.58 16.16 1.98
36 INT106604 Protein_catabolism of CIB1 4 0.90 1.24 1.98
37 INT146793 Positive_regulation of Tp53 30 0.70 32.93 1.94
38 INT65855 Localization of TP53 18 0.76 17.08 1.89
39 INT69222 Positive_regulation of Sod1 15 0.61 8.19 1.87
40 INT145655 Transcription of Sod1 3 0.42 0.92 1.84
41 INT69221 Negative_regulation of Sod1 14 0.56 10.57 1.83
42 INT113345 Positive_regulation of Phosphorylation of TP53 8 0.66 6.11 1.8
43 INT106615 Gene_expression of CIB1 4 0.70 1.61 1.76
44 INT86909 Negative_regulation of MSH2 9 0.41 12.65 1.7
45 INT107992 Gene_expression of MSH2 39 0.78 37.09 1.6
46 INT27293 Regulation of SOD1 21 0.53 15.73 1.55
47 INT64233 Regulation of Trp53 35 0.62 27.11 1.53
48 INT221422 Positive_regulation of BRCA1 5 0.23 12.63 1.53
49 INT91900 Localization of Sod1 12 0.77 6.62 1.51
50 INT120004 Transcription of Tp53 8 0.72 4.92 1.48
51 INT117101 Gene_expression of Sod1 18 0.67 7.93 1.47
52 INT58581 Binding of RPA1 8 0.44 1.68 1.44
53 INT101990 Negative_regulation of Positive_regulation of TP53 5 0.33 3.69 1.42
54 INT162469 Positive_regulation of Protein_catabolism of TP53 5 0.52 5.48 1.42
55 INT118155 Regulation of Positive_regulation of Prkdc 1 0.10 0.49 1.42
56 INT145658 Negative_regulation of Transcription of Sod1 1 0.34 0.15 1.42
57 INT172953 Binding of Trp53 33 0.37 20.76 1.41
58 INT93357 Regulation of Gene_expression of Trp53 15 0.62 13.4 1.41
59 INT162462 Protein_catabolism of TP53 8 0.86 7.89 1.41
60 INT145221 Binding of Tp53 10 0.37 8.59 1.37
61 INT121307 Gene_expression of Ercc1 4 0.73 12.69 1.37
62 INT119062 Negative_regulation of BRCA1 12 0.49 13.7 1.36
63 INT34140 Negative_regulation of Vcp 2 0.10 0.23 1.32
64 INT106617 Regulation of Protein_catabolism of CIB1 1 0.56 0.46 1.29
65 INT152255 Gene_expression of ATM 14 0.71 12.53 1.26
66 INT106619 Regulation of CIB1 1 0.41 0.51 1.23
67 INT125525 Positive_regulation of PRKDC 7 0.45 2.72 1.21
68 INT117100 Positive_regulation of Gene_expression of Sod1 5 0.60 1.18 1.2
69 INT174156 Localization of Trp53 16 0.72 13.52 1.18
70 INT116436 Negative_regulation of Phosphorylation of TP53 2 0.40 0.94 1.16
71 INT134661 Negative_regulation of Tp53 11 0.43 10.91 1.13
72 INT91872 Gene_expression of RPA1 9 0.77 5.28 1.12
73 INT159543 Localization of SOD1 29 0.75 8.62 1.06
74 INT129398 Negative_regulation of Gene_expression of SOD1 22 0.43 7.11 1.02
75 INT97052 Transcription of Trp53 12 0.64 6.52 1.01
76 INT166935 Gene_expression of Prkdc 10 0.65 3.14 0.9
77 INT106602 Positive_regulation of Gene_expression of CIB1 2 0.45 1 0.83
78 INT135836 Negative_regulation of Sod1 5 0.25 1.62 0.82
79 INT93356 Negative_regulation of Gene_expression of Trp53 28 0.53 20.61 0.8
80 INT147433 Gene_expression of BRCA2 7 0.62 7.02 0.79
81 INT102813 Regulation of Gene_expression of TP53 25 0.59 25.95 0.75
82 INT92142 Binding of MSH2 5 0.46 5.64 0.75
83 INT168245 Positive_regulation of Transcription of Tp53 2 0.70 2.63 0.75
84 INT125526 Gene_expression of PRKDC 5 0.58 4 0.74
85 INT251735 Binding of FEN1 1 0.17 1.13 0.74
86 INT162470 Negative_regulation of Protein_catabolism of TP53 1 0.32 1.24 0.74
87 INT129630 Regulation of Sod1 6 0.44 4.94 0.73
88 INT106609 Regulation of Gene_expression of CIB1 2 0.41 0.97 0.73
89 INT28561 Regulation of Gene_expression of SOD1 9 0.61 2.83 0.71
90 INT303799 Phosphorylation of Tdp1 1 0.82 22.84 0.71
91 INT25176 Regulation of Msh2 3 0.37 0.48 0.68
92 INT56251 Binding of NBN 4 0.38 3.16 0.62
93 INT93358 Negative_regulation of Positive_regulation of Trp53 9 0.41 3.95 0.6
94 INT53950 Phosphorylation of Tp53 8 0.61 9.4 0.6
95 INT303804 Localization of Tdp1 1 0.80 11.71 0.59
96 INT48212 Binding of ATM 5 0.47 3.89 0.57
97 INT333877 Protein_catabolism of LIG4 2 0.03 2.03 0.57
98 INT160777 Transcription of CHEK2 1 0.52 1.03 0.57
99 INT160778 Transcription of ATM 1 0.40 1.03 0.57
100 INT221420 Positive_regulation of Gene_expression of BRCA1 2 0.24 2.17 0.55
101 INT162429 Negative_regulation of Gene_expression of Sod1 6 0.48 2.46 0.53
102 INT160776 Positive_regulation of Positive_regulation of ATM 2 0.43 0.94 0.53
103 INT124774 Binding of Vcp 4 0.44 3.4 0.52
104 INT25175 Gene_expression of Msh2 2 0.55 0.4 0.52
105 INT146545 Negative_regulation of Gene_expression of MSH2 17 0.56 18.87 0.51
106 INT286035 Negative_regulation of Gene_expression of Tp53 5 0.32 6.2 0.49
107 INT309465 Gene_expression of Xrcc6 24 0.59 5.49 0.43
108 INT121310 Positive_regulation of Ercc1 2 0.45 1.78 0.42
109 INT315892 Negative_regulation of Binding of ATM 1 0.07 1.41 0.4
110 INT154768 Negative_regulation of ATM 10 0.57 7.05 0.39
111 INT139976 Regulation of Tp53 7 0.44 6.49 0.39
112 INT219001 Gene_expression of ERCC1 12 0.54 3.77 0.38
113 INT58580 Positive_regulation of Binding of RPA1 2 0.43 0 0.38
114 INT158641 Positive_regulation of CHEK2 5 0.35 4.15 0.37
115 INT187472 Regulation of Gene_expression of Sod1 5 0.53 2.68 0.37
116 INT145220 Negative_regulation of Binding of Tp53 1 0.20 0.75 0.36
117 INT188016 Gene_expression of TP53BP1 6 0.64 5.54 0.35
118 INT303808 Positive_regulation of Gene_expression of Tdp1 1 0.69 9.07 0.35
119 INT105934 Gene_expression of APTX 1 0.00 0 0.35
120 INT353457 Positive_regulation of Binding of BRCA1 1 0.09 1.69 0.34
121 INT303811 Binding of Tdp1 1 0.37 8.69 0.33
122 INT221419 Regulation of BRCA1 5 0.35 6.18 0.31
123 INT123622 Negative_regulation of Vcp 5 0.42 2.51 0.3
124 INT93355 Negative_regulation of Negative_regulation of Trp53 2 0.41 0.92 0.3
125 INT179089 Protein_catabolism of Trp53 8 0.90 6.52 0.29
126 INT125524 Positive_regulation of Gene_expression of PRKDC 2 0.09 1 0.29
127 INT129632 Negative_regulation of Transcription of Sod1 1 0.43 0.69 0.28
128 INT129631 Transcription of Sod1 1 0.52 0.69 0.28
129 INT167438 Localization of ATM 3 0.55 1.61 0.27
130 INT180393 Positive_regulation of Gene_expression of Prkdc 3 0.49 1.17 0.26
131 INT166960 Positive_regulation of Negative_regulation of TP53 2 0.25 1.65 0.26
132 INT173223 Negative_regulation of BRCA2 7 0.54 6.79 0.25
133 INT129399 Transcription of SOD1 6 0.66 3.08 0.25
134 INT188021 Positive_regulation of TP53BP1 3 0.48 1.33 0.25
135 INT220604 Binding of Kat5 2 0.11 0.7 0.25
136 INT314729 Regulation of Localization of TP53 1 0.30 2.5 0.25
137 INT158642 Regulation of Positive_regulation of CHEK2 1 0.07 1.27 0.25
138 INT220582 Binding of Apbb1 2 0.14 0.69 0.24
139 INT179088 Positive_regulation of Regulation of Trp53 3 0.38 3.23 0.23
140 INT156886 Positive_regulation of Localization of TP53 1 0.48 0.87 0.23
141 INT327888 Localization of Prkdc 1 0.14 1.11 0.23
142 INT121311 Positive_regulation of Gene_expression of Ercc1 3 0.62 1.23 0.21
143 INT220727 Regulation of Binding of SOD1 1 0.42 1.46 0.21
144 INT238309 Negative_regulation of Gene_expression of Sod1 3 0.38 1.09 0.2
145 INT116432 Positive_regulation of Positive_regulation of SOD1 3 0.40 3.88 0.2
146 INT309493 Binding of Xrcc6 1 0.37 3 0.2
147 INT19359 Binding of BRCA2 5 0.47 2.63 0.19
148 INT174127 Positive_regulation of Positive_regulation of Sod1 2 0.45 4.9 0.19
149 INT303812 Regulation of Tdp1 1 0.45 3.32 0.19
150 INT221268 Localization of BRCA1 7 0.63 4.83 0.18
151 INT240279 Negative_regulation of Positive_regulation of SOD1 5 0.43 2.45 0.18
152 INT119061 Negative_regulation of Gene_expression of BRCA1 4 0.51 0.85 0.18
153 INT89690 Binding of Brca2 2 0.37 1.8 0.18
154 INT89689 Binding of Brca1 2 0.37 2.55 0.18
155 INT188019 Negative_regulation of TP53BP1 1 0.48 1.42 0.18
156 INT335731 Gene_expression of Vcp 1 0.73 12.21 0.18
157 INT182627 Regulation of MSH2 1 0.26 2.27 0.18
158 INT169875 Negative_regulation of Ercc1 3 0.43 3.07 0.17
159 INT319180 Regulation of Transcription of SOD1 1 0.21 0.3 0.17
160 INT300284 Regulation of Phosphorylation of Tp53 1 0.16 1.51 0.17
161 INT337078 Negative_regulation of Localization of Trp53 1 0.20 1.3 0.17
162 INT260849 Gene_expression of NBN 9 0.67 7.11 0.16
163 INT142384 Gene_expression of XRCC6 3 0.58 1.98 0.16
164 INT238306 Regulation of Gene_expression of Sod1 1 0.39 0.46 0.16
165 INT91870 Negative_regulation of Gene_expression of RPA1 1 0.58 0.4 0.16
166 INT179086 Positive_regulation of Negative_regulation of Trp53 5 0.50 4.78 0.15
167 INT125081 Positive_regulation of Binding of TP53 2 0.46 1.2 0.15
168 INT207805 Negative_regulation of Phosphorylation of Trp53 2 0.18 0.98 0.15
169 INT91871 Transcription of RPA1 1 0.69 0.38 0.15
170 INT286749 Regulation of Localization of Trp53 1 0.06 1.39 0.15
171 INT91866 Positive_regulation of Gene_expression of RPA1 1 0.69 0.38 0.15
172 INT204370 Negative_regulation of Binding of SOD1 4 0.41 0.82 0.13
173 INT89691 Regulation of Brca2 1 0.23 0.56 0.13
174 INT314356 Positive_regulation of Localization of SOD1 1 0.04 0.82 0.13
175 INT168244 Regulation of Transcription of Tp53 1 0.33 0.57 0.13
176 INT68177 Negative_regulation of APTX 1 0.20 0.33 0.13
177 INT278288 Regulation of Localization of ATM 1 0.09 0.95 0.13
178 INT309492 Positive_regulation of Gene_expression of Xrcc6 1 0.38 1.29 0.13
179 INT290726 Binding of Prkdc 1 0.03 1.05 0.13
180 INT237045 Positive_regulation of Vcp 7 0.62 6.96 0.12
181 INT182623 Localization of MSH2 3 0.77 5.49 0.12
182 INT167440 Regulation of ATM 2 0.20 0.68 0.12
183 INT229429 Localization of Sod1 2 0.65 0.8 0.12
184 INT187590 Gene_expression of Brca1 12 0.65 4.94 0.11
185 INT181745 Positive_regulation of MSH2 4 0.48 5.73 0.11
186 INT231413 Negative_regulation of NBN 3 0.46 4.6 0.11
187 INT208914 Regulation of Brca1 1 0.10 0.79 0.11
188 INT211717 Gene_expression of CHEK2 13 0.37 2.13 0.1
189 INT204330 Protein_catabolism of SOD1 8 0.84 4.75 0.1
190 INT268725 Positive_regulation of Negative_regulation of SOD1 3 0.35 2.41 0.1
191 INT177582 Regulation of Sod1 2 0.24 0.39 0.1
192 INT297456 Protein_catabolism of Tp53 1 0.11 0.72 0.1
193 INT41285 Regulation of Vcp 1 0.11 0.32 0.1
194 INT203330 Negative_regulation of Binding of Sod1 1 0.28 1.03 0.1
195 INT226076 Regulation of RPA1 1 0.25 0.43 0.1
196 INT111139 Localization of Tp53 4 0.45 2.4 0.09
197 INT194320 Localization of RPA1 2 0.06 0.17 0.09
198 INT352666 Regulation of PRKDC 1 0.01 0.36 0.09
199 INT321675 Gene_expression of Apbb1 1 0.32 1 0.09
200 INT252574 Negative_regulation of Regulation of SOD1 1 0.06 1.11 0.09
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