GO:0006306

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Name DNA methylation
Categary Process
Go Slim No
Go Link GO:0006306
Unique Molecular Interactions 132
Total Molecular Interactions 162
Total Single Events 2038
Pain Genes Associated 12

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for DNA methylation. They are ordered first by their pain relevance and then by number of times they were reported for DNA methylation. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT94203 SP5 Positive_regulation of FOS 1 0.25 1.41 1.72
2 INT73116 TYMS Negative_regulation of DNMT3B 1 0.24 0 1.6
3 INT73115 TYMS Negative_regulation of Positive_regulation of DNMT3B 1 0.24 0 1.6
4 INT115985 Cpe Positive_regulation of Binding of Gnas 1 0.00 0.17 1.28
5 INT70181 PRCP Positive_regulation of FOS 1 0.58 0.36 1.26
6 INT150191 CEACAM3 Positive_regulation of Gene_expression of FOS 1 0.34 0.14 1.16
7 INT130627 Gnas Regulation of Prkaca 1 0.00 0 1.13
8 INT94206 SP5 Regulation of Gene_expression of FOS 1 0.22 0.7 0.98
9 INT249347 Binding of FOS and JUN 4 0.19 6.15 0.89
10 INT124878 Gnat3 Negative_regulation of Gene_expression of FOS 1 0.09 0.16 0.85
11 INT124877 Gnat3 Negative_regulation of FOS 1 0.09 0.15 0.82
12 INT124876 Gnat3 Negative_regulation of Positive_regulation of FOS 1 0.09 0.15 0.82
13 INT341367 CRX Positive_regulation of Positive_regulation of FOS 1 0.04 0.83 0.8
14 INT186445 Creb1 Regulation of Transcription of FOS 1 0.49 0.44 0.73
15 INT186443 Phosphorylation of Creb1 Regulation of Transcription of FOS 1 0.49 0.44 0.73
16 INT186444 Creb1 Regulation of FOS 1 0.49 0.43 0.72
17 INT186442 Phosphorylation of Creb1 Regulation of FOS 1 0.49 0.43 0.72
18 INT123869 Binding of GNAS and OPRK1 1 0.00 0.37 0.7
19 INT66582 Binding of FOS and Rare2 1 0.00 0.07 0.69
20 INT62059 Positive_regulation of SCN5A Positive_regulation of Gene_expression of FOS 1 0.01 0.42 0.66
21 INT81916 HSF1 Positive_regulation of FOS 1 0.76 0.66 0.59
22 INT81918 HSF1 Negative_regulation of FOS 1 0.64 0.66 0.59
23 INT343913 Binding of FOS and Smad3 1 0.19 0.92 0.54
24 INT254768 DNMT1 Positive_regulation of Gene_expression of Apoe 1 0.02 0.05 0.49
25 INT65185 Binding of ATRX and Ssr1 1 0.03 1.68 0.49
26 INT150793 ZNF398 Negative_regulation of Gene_expression of DNMT1 1 0.07 0.46 0.48
27 INT343846 MAPK1 Positive_regulation of FOS 1 0.04 1.29 0.44
28 INT104016 RPGR Positive_regulation of Gene_expression of FOS 1 0.16 0 0.43
29 INT162041 F2 Positive_regulation of Positive_regulation of FOS 1 0.13 1.14 0.41
30 INT87605 Binding of FOS and Penk 1 0.07 0.78 0.4
31 INT87604 FOS Regulation of Penk 1 0.09 0.76 0.39
32 INT87603 Binding of FOS and Jund 1 0.03 0.77 0.39
33 INT70185 PRCP Positive_regulation of Gene_expression of FOS 1 0.05 0.1 0.37
34 INT142998 ATF7IP Negative_regulation of Binding of Cnr2 1 0.00 0.14 0.34
35 INT142999 ATF7IP Negative_regulation of Binding of Cnr1 1 0.00 0.14 0.34
36 INT109894 Drd2 Positive_regulation of FOS 1 0.01 0 0.33
37 INT285718 Binding of DNMT3B and Lbp 1 0.08 0.33 0.33
38 INT69378 Positive_regulation of Binding of FOS and MBTPS1 1 0.13 0.16 0.3
39 INT70184 INSRR Positive_regulation of FOS 1 0.03 0.09 0.29
40 INT69382 Binding of FOS and MBTPS1 1 0.09 0.16 0.29
41 INT162044 F2 Positive_regulation of Localization of FOS 1 0.32 0.9 0.28
42 INT252795 IL8 Positive_regulation of Positive_regulation of FOS 1 0.01 0.75 0.25
43 INT252822 CCL2 Positive_regulation of Positive_regulation of FOS 1 0.04 0.75 0.25
44 INT228611 Binding of DNMT3B and LEP 1 0.04 0 0.25
45 INT252804 TNF Regulation of Positive_regulation of FOS 1 0.01 0.76 0.25
46 INT252786 CCL2 Regulation of Positive_regulation of FOS 1 0.05 0.75 0.25
47 INT252816 IL8 Regulation of Positive_regulation of FOS 1 0.01 0.75 0.25
48 INT252793 TNF Positive_regulation of Positive_regulation of FOS 1 0.02 0.76 0.25
49 INT264569 Binding of STS and ATF7IP 1 0.03 0.15 0.25
50 INT60194 Binding of CCK and FOS 1 0.36 0.09 0.25
51 INT254772 DNMT1 Positive_regulation of Apoe 1 0.02 0 0.25
52 INT254774 DNMT1 Positive_regulation of Localization of Apoe 1 0.01 0.31 0.23
53 INT254770 Regulation of Binding of DNMT1 and Igh-Dex 1 0.00 0 0.22
54 INT267812 Binding of ATF7IP and RLS 1 0.35 2.01 0.21
55 INT114043 Binding of CREM and FOS 1 0.04 0.17 0.19
56 INT254771 Binding of DNMT1 and Igh-Dex 1 0.00 0 0.19
57 INT148563 Ngf Positive_regulation of GNAS 1 0.06 0.07 0.16
58 INT69381 CNTN2 Positive_regulation of FOS 1 0.45 0 0.14
59 INT69385 MBTPS1 Positive_regulation of Binding of FOS 1 0.09 0 0.14
60 INT69380 CNTN2 Positive_regulation of Binding of FOS 1 0.49 0 0.14
61 INT287883 FOS Regulation of Gene_expression of EPHB2 1 0.01 0.87 0.14
62 INT69386 MBTPS1 Positive_regulation of Gene_expression of FOS 1 0.09 0 0.14
63 INT69388 CNTN2 Positive_regulation of Gene_expression of FOS 1 0.49 0 0.14
64 INT197712 Binding of HTLVR and ATF7IP 1 0.01 0.55 0.12
65 INT80619 KCNIP3 Negative_regulation of Transcription of FOS 1 0.63 0.08 0.12
66 INT255811 Binding of GNAS and MAPT 1 0.00 0.67 0.11
67 INT6674 Edn1 Positive_regulation of Gene_expression of FOS 1 0.08 0.19 0.1
68 INT255289 Snap25 Regulation of Gene_expression of Gnas 1 0.00 0 0.09
69 INT311083 DST Regulation of FOS 1 0.03 0.15 0.08
70 INT284303 Mir155 Negative_regulation of Gnas 1 0.00 0.49 0.08
71 INT306273 Binding of FOS and NFAT5 1 0.15 0.22 0.08
72 INT216129 SRF Positive_regulation of Gene_expression of FOS 1 0.28 0.32 0.07
73 INT228610 Binding of DNMT3B and ASPRV1 1 0.02 0 0.05
74 INT279885 Ctcf Regulation of H19 1 0.12 0 0
75 INT66341 LIF Positive_regulation of Gene_expression of FOS 1 0.11 1.07 0
76 INT241268 DNMT3B Positive_regulation of Gene_expression of DNMT1 1 0.19 0.67 0
77 INT183412 Dnmt3a Positive_regulation of Tbx15 1 0.05 0.27 0
78 INT249538 Binding of BDNF and GNAS 1 0.08 0 0
79 INT243318 MAPK3 Negative_regulation of FOS 1 0.04 0.14 0
80 INT284304 Binding of Adrb3 and Gnas 1 0.00 0.23 0
81 INT179302 Gene_expression of GNAS Negative_regulation of CA2 1 0.01 0 0
82 INT145148 Positive_regulation of Binding of EGFR and FOS 1 0.50 0.05 0
83 INT284918 RUNX1T1 Regulation of DNMT1 1 0.21 1.09 0
84 INT250658 FOS Positive_regulation of CCND1 1 0.03 0.6 0
85 INT284302 Mir155 Regulation of Gnas 1 0.00 0.64 0
86 INT241266 DNMT3B Positive_regulation of Gene_expression of GOPC 1 0.05 0.68 0
87 INT183413 Dnmt3a Positive_regulation of Gene_expression of Dnmt3b 1 0.10 0.28 0
88 INT241264 DNMT1 Positive_regulation of Gene_expression of DNMT3B 1 0.19 0.67 0
89 INT241257 DNMT3B Positive_regulation of OPCML 1 0.35 0.68 0
90 INT318132 Binding of ATRX and HBE1 1 0.00 1.47 0
91 INT241259 DNMT3B Positive_regulation of GOPC 1 0.05 0.68 0
92 INT182921 Binding of FOS and PITPNM1 1 0.03 0 0
93 INT183415 Dnmt3b Positive_regulation of Gene_expression of Dnmt3a 1 0.10 0.28 0
94 INT333558 CD14 Positive_regulation of FOS 1 0.04 0.09 0
95 INT253331 Binding of DNMT3B and SP140 1 0.04 0.17 0
96 INT183410 Dnmt3b Positive_regulation of Tbx15 1 0.05 0.27 0
97 INT231169 Gnas Positive_regulation of Gene_expression of Dmd 1 0.00 0.19 0
98 INT333562 IRF6 Positive_regulation of FOS 1 0.01 0.09 0
99 INT241265 DNMT1 Positive_regulation of OPCML 1 0.31 0.68 0
100 INT283201 Gm4658 Regulation of Gnas 1 0.00 0.56 0
101 INT241269 DNMT1 Positive_regulation of Gene_expression of GOPC 1 0.04 0.68 0
102 INT191135 Binding of DNMT3A and DNMT3B 1 0.09 0 0
103 INT342096 Binding of Polr2f and Ehmt1 1 0.00 0.73 0
104 INT57384 Binding of FOS and Creb1 1 0.29 0.59 0
105 INT241254 DNMT1 Positive_regulation of GOPC 1 0.04 0.68 0
106 INT108360 Prkaca Regulation of Phosphorylation of FOS 1 0.66 0 0
107 INT145151 Binding of EGFR and FOS 1 0.48 0.05 0
108 INT325836 Binding of Dnm2 and Gnas 1 0.00 0.22 0
109 INT325839 Binding of Dnm1 and Gnas 1 0.00 0.11 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for DNA methylation. They are ordered first by their pain relevance and then by number of times they were reported in DNA methylation. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT6665 Gene_expression of FOS 520 0.77 165.31 217.66
2 INT17459 Positive_regulation of Gene_expression of FOS 182 0.67 53.45 96.38
3 INT5356 Positive_regulation of FOS 153 0.69 54.21 56.74
4 INT17458 Negative_regulation of Gene_expression of FOS 98 0.57 36.77 55.69
5 INT48979 Regulation of Gene_expression of FOS 52 0.61 14.4 25.95
6 INT15246 Regulation of FOS 32 0.60 15.34 12.94
7 INT62919 Regulation of Gnas 22 0.43 5.61 9.55
8 INT48978 Negative_regulation of FOS 41 0.57 11.94 9.14
9 INT17333 Positive_regulation of Positive_regulation of FOS 17 0.67 6.06 8.4
10 INT47848 Negative_regulation of Positive_regulation of FOS 14 0.57 3.78 7.63
11 INT60196 Binding of FOS 33 0.47 13.11 6.95
12 INT5847 Transcription of FOS 31 0.69 11.11 6.41
13 INT11258 Gene_expression of Gnas 58 0.58 21.6 6.33
14 INT67635 Negative_regulation of Gnas 29 0.04 11.4 6.32
15 INT73117 Positive_regulation of DNMT3B 20 0.47 10.31 5.31
16 INT54911 Localization of FOS 20 0.78 3.27 4.56
17 INT98357 Binding of Gnas 11 0.41 1.87 4.35
18 INT32933 Gene_expression of GNAS 57 0.32 10.58 4.03
19 INT103350 Gene_expression of DNMT1 15 0.67 9.77 3.83
20 INT136106 Gene_expression of DNMT3B 30 0.58 8.43 3.7
21 INT85260 Negative_regulation of ATF7IP 14 0.41 7.08 3.17
22 INT121531 Negative_regulation of DNMT3B 13 0.36 3.46 3.05
23 INT133038 Binding of DNMT3B 26 0.40 5.97 2.83
24 INT108358 Phosphorylation of FOS 12 0.80 6.33 2.79
25 INT48980 Positive_regulation of Transcription of FOS 10 0.67 3.07 2.34
26 INT179311 Transcription of GNAS 2 0.10 0.67 2.08
27 INT108903 Negative_regulation of GNAS 7 0.57 1.58 2.04
28 INT9953 Positive_regulation of Gnas 10 0.34 3.21 1.51
29 INT121347 Binding of GNAS 8 0.13 3.99 1.47
30 INT162308 Phosphorylation of GNAS 3 0.01 1.71 1.4
31 INT157500 Localization of DNMT3B 12 0.73 2.21 1.38
32 INT148562 Positive_regulation of GNAS 13 0.16 5.31 1.32
33 INT46336 Regulation of DNMT3B 12 0.53 4.91 1.25
34 INT958 Negative_regulation of ATRX 6 0.58 2.92 1.25
35 INT322088 Regulation of Regulation of DNMT3B 1 0.03 2.74 1.12
36 INT17332 Regulation of Positive_regulation of FOS 6 0.44 0.78 1.11
37 INT69394 Positive_regulation of Binding of FOS 6 0.49 3.54 1.11
38 INT48982 Positive_regulation of Regulation of FOS 2 0.45 0.15 1.11
39 INT285716 Negative_regulation of Gene_expression of DNMT3B 1 0.21 0.96 0.96
40 INT59909 Binding of ATF7IP 4 0.36 2.83 0.9
41 INT179857 Gene_expression of ATF7IP 14 0.65 4.12 0.89
42 INT959 Regulation of ATRX 5 0.47 5.04 0.89
43 INT88179 Negative_regulation of Transcription of FOS 3 0.41 0.96 0.78
44 INT215783 Localization of Gnas 1 0.12 1.64 0.76
45 INT201859 Positive_regulation of Gene_expression of DNMT1 4 0.60 6.43 0.75
46 INT249551 Negative_regulation of Transcription of GNAS 1 0.06 0.16 0.6
47 INT241287 Positive_regulation of Gene_expression of DNMT3B 3 0.40 1.21 0.57
48 INT124875 Regulation of Localization of FOS 1 0.44 0.18 0.55
49 INT204928 Positive_regulation of ATF7IP 4 0.49 1.69 0.54
50 INT252719 Positive_regulation of Localization of FOS 1 0.06 1.47 0.49
51 INT81357 Regulation of Negative_regulation of Gnas 1 0.02 0.1 0.47
52 INT133283 Negative_regulation of Localization of FOS 2 0.41 0.29 0.46
53 INT146400 Positive_regulation of DNMT1 4 0.45 0.91 0.43
54 INT129477 Localization of ATF7IP 4 0.73 1.22 0.39
55 INT148519 Regulation of Regulation of FOS 1 0.44 1.74 0.39
56 INT306690 Negative_regulation of Dnmt3b 1 0.00 0.56 0.39
57 INT108357 Regulation of Phosphorylation of FOS 1 0.60 0.1 0.37
58 INT961 Positive_regulation of ATRX 3 0.53 1.99 0.36
59 INT179858 Negative_regulation of Gene_expression of ATF7IP 1 0.13 1.43 0.31
60 INT254763 Localization of DNMT1 1 0.05 0.2 0.29
61 INT244913 Regulation of Transcription of FOS 2 0.10 1.09 0.28
62 INT345260 Transcription of ATRX 1 0.31 0.28 0.28
63 INT962 Gene_expression of ATRX 2 0.59 1.72 0.27
64 INT284938 Regulation of DNMT1 2 0.22 1.17 0.24
65 INT300944 Regulation of DNMT3A 1 0.21 0.91 0.24
66 INT108902 Localization of GNAS 5 0.13 1.31 0.23
67 INT303912 Negative_regulation of Localization of ATF7IP 1 0.21 0.16 0.22
68 INT264577 Positive_regulation of Gene_expression of ATF7IP 2 0.17 0.68 0.19
69 INT208539 Positive_regulation of Gene_expression of Gnas 4 0.08 2.76 0.18
70 INT177433 Positive_regulation of Negative_regulation of FOS 1 0.38 0.63 0.17
71 INT273002 Regulation of ATF7IP 1 0.02 0.76 0.16
72 INT960 Negative_regulation of Positive_regulation of ATRX 1 0.45 0 0.15
73 INT291670 Negative_regulation of Dnmt3a 1 0.31 0.7 0.14
74 INT191163 Transcription of DNMT3B 4 0.50 0.46 0.13
75 INT258077 Negative_regulation of Gene_expression of DNMT1 2 0.30 1.27 0.12
76 INT258063 Negative_regulation of DNMT1 3 0.28 1.36 0.11
77 INT74442 Binding of ATRX 2 0.41 3.2 0.09
78 INT254762 Positive_regulation of Positive_regulation of DNMT1 1 0.04 0 0.09
79 INT273001 Positive_regulation of Negative_regulation of ATF7IP 1 0.02 0.09 0.09
80 INT107569 Transcription of Gnas 1 0.01 0 0.08
81 INT292609 Negative_regulation of Positive_regulation of DNMT3B 1 0.22 1.3 0.07
82 INT179307 Regulation of GNAS 7 0.01 1.93 0.05
83 INT183393 Gene_expression of Dnmt3a 3 0.43 1.08 0.04
84 INT277277 Regulation of Gene_expression of Gnas 2 0.00 0.33 0.04
85 INT291678 Regulation of Dnmt3a 1 0.28 0.48 0.04
86 INT284977 Binding of DNMT1 3 0.17 0.86 0
87 INT284943 Gene_expression of DNMT3A 2 0.39 1.46 0
88 INT177312 Negative_regulation of Gene_expression of GNAS 2 0.05 0.46 0
89 INT284945 Protein_catabolism of DNMT1 2 0.32 0.47 0
90 INT284947 Positive_regulation of Gene_expression of DNMT3A 2 0.25 1.29 0
91 INT342085 Positive_regulation of Ehmt1 1 0.01 0.4 0
92 INT255830 Positive_regulation of Localization of GNAS 1 0.01 0.28 0
93 INT191158 Transcription of DNMT3A 1 0.32 0.06 0
94 INT191157 Negative_regulation of Transcription of DNMT3B 1 0.19 0.06 0
95 INT191156 Binding of DNMT3A 1 0.16 0 0
96 INT265972 Positive_regulation of Gene_expression of ATRX 1 0.38 1.72 0
97 INT191160 Localization of DNMT3A 1 0.35 0 0
98 INT185991 Regulation of Gene_expression of DNMT3B 1 0.37 0 0
99 INT279864 Regulation of Ctcf 1 0.14 0.18 0
100 INT108359 Negative_regulation of Phosphorylation of FOS 1 0.42 0.07 0
101 INT202870 Negative_regulation of Negative_regulation of Gnas 1 0.01 0.53 0
102 INT343442 Protein_catabolism of FOS 1 0.86 0 0
103 INT272128 Positive_regulation of Localization of ATRX 1 0.14 0.46 0
104 INT179318 Regulation of Transcription of GNAS 1 0.01 0 0
105 INT191152 Negative_regulation of Transcription of DNMT3A 1 0.20 0.06 0
106 INT342075 Negative_regulation of Ehmt1 1 0.01 0.69 0
107 INT202861 Positive_regulation of Negative_regulation of Gnas 1 0.01 0.39 0
108 INT284993 Positive_regulation of Protein_catabolism of DNMT1 1 0.22 0.26 0
109 INT179310 Positive_regulation of Gene_expression of GNAS 1 0.01 0 0
110 INT351494 Positive_regulation of Protein_catabolism of GNAS 1 0.00 0.94 0
111 INT351518 Protein_catabolism of GNAS 1 0.01 1.29 0
112 INT183396 Positive_regulation of Gene_expression of Dnmt3a 1 0.20 0.59 0
113 INT255817 Positive_regulation of Positive_regulation of GNAS 1 0.01 0.85 0
114 INT343444 Negative_regulation of Regulation of FOS 1 0.42 0 0
115 INT183391 Positive_regulation of Gene_expression of Dnmt3b 1 0.20 0.59 0
116 INT249548 Negative_regulation of Positive_regulation of GNAS 1 0.06 0 0
117 INT183398 Gene_expression of Dnmt3b 1 0.27 0.59 0
118 INT338263 Regulation of Gene_expression of DNMT3A 1 0.31 0.18 0
119 INT272120 Localization of ATRX 1 0.27 1.36 0
120 INT279865 Transcription of Ctcf 1 0.36 0 0
121 INT343443 Positive_regulation of Protein_catabolism of FOS 1 0.49 0 0
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