GO:0006309

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Name DNA fragmentation involved in apoptotic nuclear change
Categary Process
Go Slim No
Go Link GO:0006309
Unique Molecular Interactions 504
Total Molecular Interactions 639
Total Single Events 7933
Pain Genes Associated 31

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for DNA fragmentation involved in apoptotic nuclear change. They are ordered first by their pain relevance and then by number of times they were reported for DNA fragmentation involved in apoptotic nuclear change. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT338167 Binding of CDKN2A and MC1R 1 0.42 6.14 5.76
2 INT155891 Nps Negative_regulation of Positive_regulation of Casp3 1 0.27 0.17 3.48
3 INT14687 Binding of Penk and Ppt1 1 0.41 0 2.46
4 INT106750 Pes1 Negative_regulation of Positive_regulation of Casp3 3 0.23 0 2.35
5 INT85252 Negative_regulation of Chi3l1 Positive_regulation of Casp3 1 0.01 0 2.26
6 INT85251 Chi3l1 Positive_regulation of Casp3 1 0.01 0 2.25
7 INT106753 Pes1 Negative_regulation of Gene_expression of Casp3 2 0.12 0 2.19
8 INT184262 Binding of AGER and HMGB1 1 0.34 4.49 2.17
9 INT146587 Npff Negative_regulation of Positive_regulation of Casp3 1 0.05 0.18 1.92
10 INT146586 Npff Negative_regulation of Gene_expression of Casp3 1 0.06 0.18 1.92
11 INT106751 Pes1 Negative_regulation of Casp3 2 0.23 0 1.54
12 INT137657 Gorasp2 Regulation of Binding of Casp3 1 0.09 0 1.52
13 INT156008 Bcl2 Regulation of Localization of Aifm1 1 0.17 1.92 1.47
14 INT167528 Ppt1 Negative_regulation of Gene_expression of Tac4 1 0.06 0.49 1.39
15 INT167529 Ppt1 Negative_regulation of Gene_expression of Trpv1 1 0.26 0.49 1.38
16 INT83707 Acyp2-ps1 Regulation of Casp3 1 0.17 0 1.28
17 INT73597 Positive_regulation of BAX Positive_regulation of Casp1 1 0.06 0.69 1.28
18 INT83705 Acyp2-ps1 Regulation of Positive_regulation of Casp3 1 0.17 0 1.28
19 INT42579 SOD1 Negative_regulation of POMC 1 0.16 0.43 1.27
20 INT73598 BAX Positive_regulation of Casp1 1 0.06 0.63 1.27
21 INT145315 D2Mit212 Regulation of Casp3 1 0.00 0 1.24
22 INT162163 CDKN2A Positive_regulation of PLD2 1 0.24 0 1.24
23 INT145316 D2Mit212 Regulation of Positive_regulation of Casp3 1 0.00 0 1.24
24 INT145317 D2Mit212 Positive_regulation of Casp3 1 0.01 0 1.22
25 INT93435 Binding of Casp3 and Cckbr 1 0.06 0.15 1.18
26 INT155892 Nps Negative_regulation of Casp3 1 0.27 0.06 1.16
27 INT155890 Nps Negative_regulation of Gene_expression of Casp3 1 0.27 0.05 1.15
28 INT112607 DNAJC15 Negative_regulation of Positive_regulation of Casp3 1 0.03 0.14 1.12
29 INT159235 H2-M3 Negative_regulation of Casp3 1 0.05 0 1.12
30 INT159236 H2-M3 Positive_regulation of Casp3 1 0.06 0 1.12
31 INT155894 Nps Regulation of Gene_expression of Casp3 1 0.33 0.07 1.09
32 INT74460 GTS Negative_regulation of Casp3 1 0.04 0.37 1.08
33 INT159237 Gpm6a Positive_regulation of Casp3 1 0.03 0 1.07
34 INT307047 Foxm1 Positive_regulation of Casp3 1 0.11 0.06 1.03
35 INT98556 Oprm1 Positive_regulation of Casp3 1 0.38 0.36 1.01
36 INT130232 Binding of Cat and Sod1 1 0.35 0.3 0.98
37 INT130231 Positive_regulation of Binding of Cat and Sod1 1 0.46 0.3 0.98
38 INT98180 Aap Positive_regulation of Positive_regulation of Casp3 1 0.00 1.08 0.97
39 INT155893 Nps Regulation of Casp3 1 0.24 0.08 0.95
40 INT73467 PTPLA Positive_regulation of Transcription of Myc 1 0.29 0.97 0.94
41 INT219154 Binding of HMGB1 and TLR4 2 0.17 4.45 0.93
42 INT70802 Ngf Regulation of Ppt1 1 0.21 0.39 0.93
43 INT220031 Casp3 Positive_regulation of Gene_expression of Nos3 1 0.04 0 0.92
44 INT148806 Diablo Positive_regulation of Positive_regulation of Casp3 1 0.03 1.02 0.89
45 INT147885 Negative_regulation of Slc6a3 Positive_regulation of Positive_regulation of Casp3 1 0.13 0 0.88
46 INT116269 Binding of Myc and Mycbp2 1 0.19 0.5 0.87
47 INT307045 Tmie Negative_regulation of Positive_regulation of Casp3 1 0.01 0.29 0.85
48 INT116250 Vta1 Positive_regulation of Casp3 1 0.01 0 0.82
49 INT56236 Casp3 Positive_regulation of Gene_expression of RT1-Cl 1 0.00 0.45 0.82
50 INT266408 Binding of HMGB1 and Ager 1 0.01 2.57 0.76
51 INT307044 Tmie Regulation of Casp3 1 0.01 0 0.75
52 INT250959 Binding of HLA-B and SOD1 1 0.05 0.75 0.75
53 INT114860 Negative_regulation of Insrr Positive_regulation of Casp3 1 0.02 0.71 0.73
54 INT220033 Casp3 Positive_regulation of Gene_expression of Nos1 1 0.05 0.52 0.72
55 INT296097 Acsm3 Negative_regulation of SOD1 1 0.01 1.3 0.72
56 INT151559 Atp2a1 Negative_regulation of Positive_regulation of CASP3 1 0.06 0.68 0.66
57 INT129694 Binding of Casp3 and Casp9 1 0.35 0.86 0.65
58 INT296793 Akt1 Positive_regulation of Gene_expression of Bax 1 0.11 0.75 0.65
59 INT296790 Tlr9 Regulation of Bax 1 0.14 0.76 0.65
60 INT296791 Positive_regulation of Akt1 Positive_regulation of Gene_expression of Bax 1 0.11 0.8 0.65
61 INT351445 Binding of Vta1 and Positive_regulation of Casp3 1 0.01 0.39 0.64
62 INT106754 Pes1 Positive_regulation of Casp3 1 0.13 0 0.63
63 INT106752 Negative_regulation of Pes1 Positive_regulation of Casp3 1 0.12 0 0.63
64 INT11558 POMC Positive_regulation of CASP3 1 0.05 0 0.62
65 INT83706 Acyp2-ps1 Positive_regulation of Casp3 1 0.11 0 0.61
66 INT112699 Bid Regulation of Bax 1 0.25 0.51 0.61
67 INT114505 Negative_regulation of Hmmr Positive_regulation of Casp3 1 0.01 0.72 0.6
68 INT114506 Hmmr Positive_regulation of Casp3 1 0.01 0.72 0.6
69 INT133320 Penk Negative_regulation of Gene_expression of Casp3 1 0.11 0.91 0.6
70 INT163376 RYBP Positive_regulation of Gene_expression of Casp3 2 0.01 0.57 0.59
71 INT112399 Olr897-ps Regulation of Gene_expression of Casp3 1 0.03 0 0.54
72 INT118082 APP Positive_regulation of Casp3 1 0.00 0.5 0.54
73 INT74517 Binding of Casp3 and Cnrip1 1 0.31 0 0.51
74 INT234609 Binding of CASP3 and IMMT 1 0.00 0.5 0.5
75 INT274625 OPN1MW Positive_regulation of SOD1 1 0.19 0.29 0.5
76 INT114593 Il1b Positive_regulation of Gene_expression of Ppt1 1 0.05 0.06 0.48
77 INT351446 Gria2 Negative_regulation of Casp3 1 0.02 0.37 0.47
78 INT307048 Cnr1 Positive_regulation of Casp3 1 0.08 0 0.47
79 INT238638 Gopc Negative_regulation of Gene_expression of Bax 1 0.04 0.85 0.45
80 INT241914 SOD1 Positive_regulation of Ros1 1 0.00 0.76 0.44
81 INT116613 Lnpep Negative_regulation of Gene_expression of BAX 1 0.42 0.62 0.43
82 INT63152 Ppt1 Regulation of Gene_expression of Pd 1 0.01 0 0.43
83 INT116612 Lnpep Negative_regulation of BAX 1 0.42 0.62 0.42
84 INT114601 Il1b Positive_regulation of Transcription of Ppt1 1 0.35 0.1 0.41
85 INT57236 Casp3 Positive_regulation of Prl 1 0.09 0 0.41
86 INT121849 CASP8 Positive_regulation of CYCS 1 0.35 0.48 0.4
87 INT158032 Binding of CDKN2A and KRT20 1 0.28 0.59 0.4
88 INT121852 CASP8 Positive_regulation of Localization of CYCS 1 0.32 0.48 0.4
89 INT57235 Casp3 Positive_regulation of Localization of Prl 1 0.15 0 0.4
90 INT334533 Binding of Foxq1 and Ngf 1 0.05 0.8 0.38
91 INT250956 Positive_regulation of Binding of HLA-B and SOD1 1 0.07 0.38 0.38
92 INT266419 HMGB1 Positive_regulation of Ager 1 0.01 1.37 0.37
93 INT52960 Casp3 Negative_regulation of Positive_regulation of Ltp 1 0.02 0 0.37
94 INT145908 Pdyn Regulation of Positive_regulation of Casp3 1 0.14 0.94 0.37
95 INT172213 Binding of BAX and BCL2L1 3 0.22 4.02 0.35
96 INT176135 AKT1 Regulation of Localization of CYCS 1 0.43 2.16 0.35
97 INT204071 HP Positive_regulation of Gene_expression of CDKN2A 1 0.00 3.48 0.34
98 INT155061 Stat3 Negative_regulation of Bax 1 0.22 3.71 0.34
99 INT130803 MC1R Regulation of Positive_regulation of Cdkn2a 1 0.17 0.82 0.34
100 INT286708 Negative_regulation of Mapk1 Negative_regulation of Casp3 1 0.12 0 0.31
101 INT163762 MDM2 Positive_regulation of Gene_expression of BAX 1 0.27 0.86 0.3
102 INT166162 Ccr9 Negative_regulation of Positive_regulation of Casp3 1 0.18 1.49 0.28
103 INT237927 BCL2 Positive_regulation of BAX 2 0.24 2.22 0.26
104 INT237919 BAX Positive_regulation of Protein_catabolism of PARP1 1 0.03 1.41 0.26
105 INT148629 Binding of Cat and Casp3 1 0.08 0.09 0.26
106 INT147593 Binding of CDK4 and CDKN2A 1 0.42 0.23 0.26
107 INT147592 Positive_regulation of Binding of CDK4 and CDKN2A 1 0.44 0.23 0.26
108 INT327300 Binding of Hnrnpd and Myc 1 0.12 1.02 0.25
109 INT121249 Binding of ANXA5 and CASP3 1 0.36 0.67 0.25
110 INT149713 Binding of Casp3 and Fas 1 0.40 1.09 0.25
111 INT266421 Binding of HMGB1 and Il1 1 0.02 0.37 0.24
112 INT171049 Binding of FAS and Positive_regulation of Gene_expression of CASP3 1 0.04 1.41 0.24
113 INT266418 Binding of HMGB1 and Tlr4 1 0.09 0.37 0.23
114 INT169614 Binding of KPNA1 and OGFR 1 0.06 0.18 0.23
115 INT289998 CNTF Negative_regulation of Casp3 1 0.04 0.99 0.22
116 INT289981 Cntf Negative_regulation of Casp3 1 0.02 1.01 0.22
117 INT349344 Bdnf Negative_regulation of Casp3 1 0.13 0.96 0.22
118 INT289999 Binding of CNTF and Casp3 1 0.04 0.99 0.22
119 INT181675 Positive_regulation of Casp9 Positive_regulation of Casp3 1 0.06 0.51 0.2
120 INT315384 Adcyap1 Negative_regulation of Positive_regulation of Casp3 1 0.02 0.53 0.2
121 INT266423 Binding of HMGB1 and Mapk3 1 0.04 0.9 0.2
122 INT305508 Binding of Sod1 and Slc17a6 1 0.03 1.1 0.2
123 INT157083 Ghrl Regulation of Gene_expression of Ppt1 1 0.40 0 0.2
124 INT266410 Binding of HMGB1 and Mapk14 1 0.03 0.91 0.2
125 INT266416 Binding of HMGB1 and Mapk1 1 0.06 0.9 0.2
126 INT266414 Binding of HMGB1 and Mapk8 1 0.03 0.91 0.2
127 INT266404 Binding of HMGB1 and Thbd 1 0.06 0.3 0.2
128 INT305511 Negative_regulation of Binding of Sod1 and Slc17a6 1 0.03 1.1 0.2
129 INT181677 Casp9 Positive_regulation of Casp3 1 0.06 0.5 0.19
130 INT28562 SOD1 Negative_regulation of Pacs1 1 0.03 2.63 0.19
131 INT261387 Nsdhl Negative_regulation of Casp3 1 0.03 1.08 0.19
132 INT192219 CASP3 Regulation of ESR1 1 0.03 1.19 0.19
133 INT197618 Binding of Esr1 and Ppt1 1 0.01 0 0.18
134 INT251492 Binding of HSPD1 and SOD1 1 0.02 1.45 0.18
135 INT250949 Binding of KIR3DL2 and SOD1 1 0.24 0.55 0.18
136 INT351442 Gria2 Regulation of Gene_expression of Casp3 1 0.01 0 0.18
137 INT275400 Casp3 Positive_regulation of NDRG1 1 0.00 1.36 0.18
138 INT155063 Csf2 Negative_regulation of Gene_expression of Bax 1 0.27 1.46 0.18
139 INT247084 Binding of F7 and H1F0 1 0.00 0.38 0.17
140 INT155066 Csf2 Negative_regulation of Bax 1 0.12 1.89 0.17
141 INT349475 Regulation of Bax Regulation of Bcl2 1 0.07 1.35 0.17
142 INT155232 TXNIP Regulation of BAX 1 0.23 0.15 0.17
143 INT96416 CYC1 Positive_regulation of Casp3 1 0.02 0.96 0.17
144 INT266422 HMGB1 Positive_regulation of Binding of Ager 1 0.01 0.92 0.16
145 INT336891 Epo Negative_regulation of Transcription of Bax 1 0.10 0.68 0.16
146 INT116268 Binding of Myc and Acsl1 1 0.08 0.19 0.16
147 INT149095 PITX2 Positive_regulation of Casp3 1 0.00 1.51 0.15
148 INT136855 Arf5 Positive_regulation of Cdkn2a 1 0.07 1.8 0.15
149 INT349476 Bax Regulation of Bcl2 1 0.07 1.33 0.15
150 INT294109 Binding of DNASE1L3 and HTR1B 1 0.01 0 0.15
151 INT292748 Akt1 Negative_regulation of Positive_regulation of Casp3 1 0.01 1.81 0.15
152 INT314856 Binding of Cdc7 and Cdkn2a 1 0.28 1.34 0.14
153 INT302146 CDKN2A Regulation of CDKN1B 1 0.11 0.51 0.14
154 INT130918 HMHA1 Positive_regulation of BAX 1 0.04 1.37 0.14
155 INT130922 HMHA1 Positive_regulation of Protein_catabolism of CYCS 1 0.06 1.39 0.14
156 INT294108 Binding of DNASE1L3 and LMOD1 1 0.08 0 0.14
157 INT302144 CDKN2A Regulation of CDKN1A 1 0.11 0.51 0.14
158 INT130917 HMHA1 Positive_regulation of CYCS 1 0.06 1.39 0.14
159 INT226205 Negative_regulation of Akt1 Positive_regulation of Casp3 1 0.04 0.71 0.14
160 INT266413 Positive_regulation of Binding of HMGB1 and Col4a1 1 0.02 1.05 0.14
161 INT266411 Binding of HMGB1 and Col4a1 1 0.01 1.05 0.14
162 INT252575 Rpe Negative_regulation of SOD1 1 0.03 2.39 0.14
163 INT294106 Binding of DNASE1L3 and DRD5 1 0.02 0 0.14
164 INT314852 Binding of Cdkn2a and Tgfbr3 1 0.28 1.15 0.14
165 INT240909 Hmgcr Regulation of Gene_expression of Sod1 1 0.03 0.53 0.14
166 INT273040 Vip Regulation of Bax 1 0.23 1.69 0.13
167 INT201722 Myc Regulation of Gene_expression of Ccnd1 1 0.03 0.79 0.13
168 INT320261 Binding of Myc and Ntrk2 1 0.01 0.36 0.13
169 INT201791 JUP Regulation of Gene_expression of Myc 1 0.49 0.8 0.13
170 INT278583 Ppt1 Negative_regulation of Gene_expression of Atp6v1e1 1 0.05 0 0.13
171 INT275397 Binding of ITIH4 and Casp3 1 0.02 0.64 0.13
172 INT273041 Adcyap1 Regulation of Bax 1 0.21 1.69 0.13
173 INT252631 Binding of Casp3 and Tnfrsf1a 1 0.10 0.69 0.13
174 INT275389 Binding of Casp3 and Htatsf1 1 0.00 0.64 0.13
175 INT342309 Apaf1 Positive_regulation of Casp9 1 0.02 1.1 0.13
176 INT334524 Sema3a Regulation of Foxq1 1 0.04 1.61 0.13
177 INT226192 Protein_catabolism of Bax Positive_regulation of Gtf3a 1 0.00 0.53 0.12
178 INT173200 PPA1 Positive_regulation of Myc 1 0.08 0.5 0.12
179 INT252632 Binding of Casp3 and Tradd 1 0.11 0.68 0.12
180 INT349345 Bdnf Negative_regulation of Positive_regulation of Casp3 1 0.13 1.02 0.12
181 INT201754 CASP8 Positive_regulation of Casp3 1 0.00 0.47 0.12
182 INT315391 IFNA1 Positive_regulation of Casp3 1 0.00 0.1 0.12
183 INT193697 Apaf1 Positive_regulation of CASP9 1 0.02 1.84 0.12
184 INT315390 Positive_regulation of IFNA1 Positive_regulation of Casp3 1 0.00 0.1 0.12
185 INT50903 Ppt1 Regulation of Tac4 1 0.18 0 0.11
186 INT285030 Binding of Bax and Slc25a4 1 0.03 0.84 0.11
187 INT142961 Binding of Nfkb1 and Casp3 1 0.00 1.02 0.11
188 INT234062 Nes Positive_regulation of Casp3 1 0.18 0.08 0.11
189 INT266900 Gene_expression of Sod2 Negative_regulation of Gene_expression of Sod1 1 0.11 0.41 0.11
190 INT50901 Ppt1 Regulation of Transcription of Tac4 1 0.18 0 0.11
191 INT265890 BCL2 Regulation of Gene_expression of BAX 1 0.04 1.08 0.1
192 INT265889 BAX Regulation of Gene_expression of BAD 1 0.06 1.08 0.1
193 INT285023 Casp3 Negative_regulation of Casp7 1 0.07 0.44 0.1
194 INT310743 TP53 Regulation of BAX 1 0.09 1.11 0.1
195 INT174133 Binding of Igfals and Sod1 3 0.19 3 0.08
196 INT221653 Binding of Myc and Gopc 2 0.12 0.51 0.08
197 INT302178 CDKN1C Regulation of CDKN2A 1 0.09 0.26 0.08
198 INT303337 Binding of SOD1 and Igfals 1 0.06 1.27 0.08
199 INT346695 Negative_regulation of SOD1 Positive_regulation of Negative_regulation of Hist3h2a 1 0.00 0.41 0.08
200 INT302158 CDKN1A Regulation of CDKN2A 1 0.04 0.26 0.08

Single Events

The table below shows the top 100 pain related interactions that have been reported for DNA fragmentation involved in apoptotic nuclear change. They are ordered first by their pain relevance and then by number of times they were reported in DNA fragmentation involved in apoptotic nuclear change. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT22548 Positive_regulation of Casp3 483 0.70 258.78 213.07
2 INT65600 Positive_regulation of Casp3 376 0.70 198.44 128.03
3 INT14151 Gene_expression of Casp3 311 0.78 140.26 120.68
4 INT31116 Gene_expression of Casp3 192 0.78 78.21 57.43
5 INT22546 Positive_regulation of Gene_expression of Casp3 97 0.70 47.89 51.92
6 INT49552 Negative_regulation of Positive_regulation of Casp3 76 0.55 36.04 44.78
7 INT27493 Negative_regulation of Casp3 114 0.56 56.89 44.63
8 INT11560 Positive_regulation of CASP3 236 0.70 184.33 39.38
9 INT65597 Negative_regulation of Casp3 69 0.59 39.19 29.32
10 INT65598 Negative_regulation of Positive_regulation of Casp3 45 0.59 18.36 28.59
11 INT14575 Positive_regulation of Ppt1 60 0.70 9.97 27.4
12 INT90313 Negative_regulation of Gene_expression of Casp3 57 0.57 22.23 26.77
13 INT100423 Gene_expression of Bax 141 0.75 98.43 24.48
14 INT22549 Positive_regulation of Positive_regulation of Casp3 48 0.56 29.5 23.7
15 INT29704 Regulation of Casp3 51 0.56 22.13 22.79
16 INT4890 Gene_expression of Ppt1 51 0.77 8.93 21.83
17 INT4894 Transcription of Ppt1 34 0.67 5.93 21.06
18 INT73593 Gene_expression of BAX 173 0.76 147.81 20.94
19 INT78694 Positive_regulation of Gene_expression of Casp3 46 0.66 18.64 19.62
20 INT22547 Regulation of Gene_expression of Casp3 23 0.62 8.04 16.78
21 INT108588 Gene_expression of CASP3 126 0.78 84.49 16.2
22 INT78697 Negative_regulation of Gene_expression of Casp3 33 0.57 11.22 16.16
23 INT8794 Negative_regulation of Ppt1 35 0.57 6.44 14.52
24 INT109511 Gene_expression of Bax 133 0.78 113.22 14.36
25 INT94774 Regulation of CDKN2A 43 0.60 44.41 13.99
26 INT78472 Gene_expression of CDKN2A 223 0.78 173.76 13.61
27 INT31990 Positive_regulation of SOD1 124 0.69 67.79 12.52
28 INT14510 Gene_expression of SOD1 208 0.76 88.56 12.4
29 INT81626 Positive_regulation of Positive_regulation of Casp3 34 0.69 16.75 12.18
30 INT78695 Regulation of Casp3 24 0.44 9.43 10.48
31 INT29705 Regulation of Positive_regulation of Casp3 13 0.48 5.37 10.45
32 INT102110 Positive_regulation of Gene_expression of Bax 42 0.67 35.77 9.51
33 INT102106 Positive_regulation of Bax 48 0.67 30.62 9.28
34 INT73596 Positive_regulation of Gene_expression of BAX 43 0.67 40.97 9.22
35 INT105103 Regulation of Gene_expression of Casp3 11 0.39 3.15 9.22
36 INT24651 Positive_regulation of Transcription of Ppt1 12 0.47 2.88 8.42
37 INT78696 Regulation of Positive_regulation of Casp3 9 0.39 2.93 8.2
38 INT67037 Gene_expression of Sod1 121 0.78 59.32 7.99
39 INT73595 Positive_regulation of BAX 61 0.61 56.97 7.82
40 INT98178 Localization of Casp3 32 0.65 21.01 7.77
41 INT92138 Binding of CDKN2A 28 0.37 25.64 7.47
42 INT102107 Negative_regulation of Gene_expression of Bax 30 0.57 29.48 7.33
43 INT5774 Regulation of Ppt1 22 0.60 4.97 7.1
44 INT102814 Negative_regulation of CASP3 46 0.43 28.54 6.94
45 INT102749 Positive_regulation of Positive_regulation of CASP3 32 0.67 26.07 6.93
46 INT14903 Negative_regulation of SOD1 81 0.57 42.02 6.91
47 INT108585 Positive_regulation of Gene_expression of CASP3 35 0.70 28.37 6.45
48 INT98837 Positive_regulation of Bax 72 0.61 63.14 6.41
49 INT57232 Binding of Casp3 22 0.36 9.42 6.2
50 INT134544 Negative_regulation of Positive_regulation of CASP3 23 0.57 18.48 5.95
51 INT4888 Positive_regulation of Gene_expression of Ppt1 9 0.54 2.78 5.83
52 INT17892 Gene_expression of Myc 57 0.75 36.37 5.82
53 INT125467 Positive_regulation of Gene_expression of CDKN2A 35 0.63 39.07 5.56
54 INT13295 Positive_regulation of Cdkn2a 18 0.68 13.02 5.47
55 INT89794 Positive_regulation of CDKN2A 58 0.67 50.18 5.38
56 INT55353 Negative_regulation of Positive_regulation of Ppt1 9 0.57 0.31 5.37
57 INT145929 Regulation of Bax 20 0.60 18.12 5.35
58 INT109513 Positive_regulation of Gene_expression of Bax 37 0.67 29.52 5.06
59 INT137332 Positive_regulation of Gene_expression of Sod1 41 0.70 19.8 4.69
60 INT184269 Gene_expression of HMGB1 51 0.77 42.96 4.55
61 INT99504 Negative_regulation of Bax 19 0.56 8.89 4.44
62 INT101858 Negative_regulation of BAX 25 0.57 23.77 4.16
63 INT84686 Regulation of BAX 26 0.49 28.54 4.13
64 INT123752 Regulation of Bax 19 0.60 16.45 4
65 INT112692 Localization of Bax 31 0.80 20.97 3.98
66 INT184288 Localization of HMGB1 20 0.61 14.5 3.84
67 INT88805 Protein_catabolism of CASP3 24 0.86 18.38 3.7
68 INT164540 Localization of Aifm1 15 0.46 13.87 3.65
69 INT97126 Regulation of CASP3 9 0.40 8.15 3.6
70 INT55352 Regulation of Gene_expression of Ppt1 9 0.44 0.4 3.51
71 INT95119 Localization of CYCS 23 0.78 14.86 3.49
72 INT137634 Localization of Aifm1 17 0.80 11.8 3.45
73 INT124579 Localization of BAX 35 0.78 30.31 3.43
74 INT14857 Negative_regulation of Gene_expression of Ppt1 7 0.42 1.16 3.3
75 INT78471 Regulation of Gene_expression of CDKN2A 13 0.45 12.52 3.28
76 INT137656 Negative_regulation of Binding of Casp3 4 0.21 0.7 3.09
77 INT137961 Localization of Ppt1 1 0.64 2.89 3.09
78 INT141180 Gene_expression of Apaf1 6 0.74 5.77 2.98
79 INT39344 Gene_expression of DNASE1L3 12 0.54 2.25 2.88
80 INT36886 Transcription of Myc 6 0.69 3.16 2.86
81 INT78248 Negative_regulation of Cdkn2a 17 0.59 15.15 2.8
82 INT88852 Protein_catabolism of Casp3 28 0.65 23.57 2.74
83 INT91899 Binding of Sod1 17 0.47 11.56 2.63
84 INT73460 Positive_regulation of Gene_expression of Myc 26 0.67 20.44 2.61
85 INT31989 Binding of SOD1 43 0.47 19.38 2.55
86 INT184272 Binding of HMGB1 14 0.37 8.78 2.49
87 INT92141 Negative_regulation of CDKN2A 53 0.57 44.23 2.48
88 INT195005 Positive_regulation of Aifm1 11 0.29 7.92 2.46
89 INT131112 Phosphorylation of Casp3 7 0.63 4.1 2.46
90 INT338170 Regulation of Regulation of CDKN2A 1 0.44 0.96 2.46
91 INT102146 Phosphorylation of Bax 4 0.66 3.48 2.35
92 INT151574 Gene_expression of Aifm1 5 0.62 3.63 2.34
93 INT74237 Positive_regulation of Ppt1 3 0.49 2.92 2.32
94 INT31118 Localization of Casp3 17 0.73 11.55 2.3
95 INT130230 Positive_regulation of Sod1 3 0.67 1.63 2.3
96 INT65948 Binding of DNASE1L3 8 0.31 1.38 2.21
97 INT108589 Negative_regulation of Gene_expression of CASP3 13 0.57 10.52 2.14
98 INT103966 Negative_regulation of Gene_expression of BAX 9 0.56 7.95 2.14
99 INT77627 Regulation of Gene_expression of BAX 14 0.44 15.09 2.12
100 INT98176 Positive_regulation of Localization of Casp3 7 0.33 6.85 2.12
101 INT154970 Localization of Bax 15 0.74 11.12 2.11
102 INT94772 Gene_expression of Cdkn2a 14 0.75 8.25 2.04
103 INT96764 Positive_regulation of Gene_expression of SOD1 36 0.61 16.55 1.99
104 INT98836 Transcription of Bax 6 0.69 5.04 1.96
105 INT134442 Transcription of Bax 14 0.67 7.6 1.9
106 INT135540 Negative_regulation of Bax 16 0.48 11.8 1.89
107 INT69222 Positive_regulation of Sod1 15 0.61 8.19 1.87
108 INT141191 Positive_regulation of Gene_expression of Apaf1 1 0.48 2.33 1.85
109 INT134443 Binding of Bax 10 0.47 5.62 1.84
110 INT145655 Transcription of Sod1 3 0.42 0.92 1.84
111 INT69221 Negative_regulation of Sod1 14 0.56 10.57 1.83
112 INT14862 Negative_regulation of Transcription of Ppt1 3 0.42 0 1.8
113 INT156005 Positive_regulation of Gene_expression of Aifm1 1 0.36 1.56 1.75
114 INT104883 Positive_regulation of Positive_regulation of Bax 4 0.45 4.05 1.74
115 INT144292 Binding of Ppt1 9 0.37 2.02 1.71
116 INT102532 Protein_catabolism of Casp3 24 0.64 16.78 1.64
117 INT198663 Positive_regulation of HMGB1 14 0.52 11.41 1.58
118 INT27293 Regulation of SOD1 21 0.53 15.73 1.55
119 INT184271 Positive_regulation of Gene_expression of HMGB1 7 0.41 6.17 1.53
120 INT91900 Localization of Sod1 12 0.77 6.62 1.51
121 INT110749 Gene_expression of Ppt1 9 0.34 0.51 1.49
122 INT106749 Negative_regulation of Negative_regulation of Casp3 6 0.34 5.12 1.48
123 INT117101 Gene_expression of Sod1 18 0.67 7.93 1.47
124 INT146785 Positive_regulation of Localization of Bax 7 0.69 6.16 1.47
125 INT340324 Regulation of Ppt1 1 0.13 1.17 1.47
126 INT105086 Positive_regulation of CYCS 9 0.49 5.82 1.45
127 INT109512 Negative_regulation of Gene_expression of Bax 12 0.42 8.04 1.44
128 INT140843 Regulation of Phosphorylation of Casp3 1 0.25 0.37 1.44
129 INT145658 Negative_regulation of Transcription of Sod1 1 0.34 0.15 1.42
130 INT78470 Negative_regulation of Gene_expression of CDKN2A 14 0.59 14.44 1.38
131 INT141037 Positive_regulation of Aifm1 3 0.45 3.32 1.38
132 INT164541 Negative_regulation of Localization of Aifm1 3 0.27 4.51 1.38
133 INT172452 Gene_expression of Myc 121 0.78 69.56 1.36
134 INT116265 Binding of Myc 9 0.36 4.28 1.36
135 INT171690 Transcription of Casp3 8 0.55 2.62 1.36
136 INT97943 Positive_regulation of Protein_catabolism of Casp3 7 0.28 7.4 1.35
137 INT4889 Regulation of Transcription of Ppt1 3 0.35 0.89 1.34
138 INT53316 Localization of Ppt1 5 0.65 1.59 1.32
139 INT112695 Negative_regulation of Protein_catabolism of Bax 3 0.36 1.72 1.3
140 INT63532 Positive_regulation of Positive_regulation of Ppt1 2 0.67 0 1.29
141 INT195013 Positive_regulation of Localization of Aifm1 1 0.27 4.18 1.29
142 INT154969 Positive_regulation of Localization of Bax 4 0.64 3.42 1.27
143 INT37646 Negative_regulation of Aifm1 2 0.47 1.28 1.26
144 INT117100 Positive_regulation of Gene_expression of Sod1 5 0.60 1.18 1.2
145 INT112693 Protein_catabolism of Bax 5 0.74 3.17 1.2
146 INT111340 Positive_regulation of Localization of CYCS 7 0.67 4.83 1.19
147 INT55351 Positive_regulation of Negative_regulation of Ppt1 3 0.45 0 1.19
148 INT219168 Positive_regulation of Localization of HMGB1 5 0.36 4 1.16
149 INT141179 Negative_regulation of Apaf1 2 0.41 1.53 1.14
150 INT141181 Negative_regulation of Transcription of Apaf1 1 0.40 1.42 1.14
151 INT141182 Transcription of Apaf1 1 0.68 1.41 1.14
152 INT141189 Negative_regulation of Transcription of Bax 1 0.41 1.42 1.14
153 INT53028 Negative_regulation of CYCS 6 0.57 2.65 1.11
154 INT71848 Positive_regulation of Transcription of Myc 1 0.67 0.16 1.11
155 INT75698 Negative_regulation of Negative_regulation of Ppt1 1 0.42 1.01 1.11
156 INT75699 Negative_regulation of Ppt1 2 0.58 1.07 1.08
157 INT141036 Negative_regulation of Aifm1 1 0.00 1.26 1.07
158 INT159543 Localization of SOD1 29 0.75 8.62 1.06
159 INT102845 Localization of CASP3 7 0.81 2.81 1.06
160 INT42104 Regulation of Cdkn2a 4 0.44 5.67 1.06
161 INT129398 Negative_regulation of Gene_expression of SOD1 22 0.43 7.11 1.02
162 INT102070 Regulation of Gene_expression of Myc 4 0.60 2.68 0.96
163 INT175507 Regulation of Gene_expression of Bax 13 0.50 10.91 0.95
164 INT338168 Positive_regulation of Binding of CDKN2A 1 0.49 0.52 0.94
165 INT98134 Binding of BAX 17 0.39 11.45 0.93
166 INT31117 Binding of Casp3 14 0.23 5.27 0.93
167 INT17894 Regulation of Myc 10 0.60 5.65 0.93
168 INT47039 Regulation of SFRP1 14 0.62 7.44 0.92
169 INT115845 Positive_regulation of Gene_expression of DNASE1L3 2 0.40 0.58 0.9
170 INT55350 Regulation of Negative_regulation of Ppt1 2 0.60 0 0.86
171 INT137512 Positive_regulation of Positive_regulation of BAX 5 0.49 4.91 0.85
172 INT131105 Positive_regulation of Negative_regulation of Casp3 3 0.29 3.15 0.84
173 INT135836 Negative_regulation of Sod1 5 0.25 1.62 0.82
174 INT144697 Regulation of Gene_expression of Bax 8 0.37 9.5 0.81
175 INT1523 Binding of CYCS 4 0.47 0.53 0.8
176 INT82896 Transcription of BAX 3 0.67 4.61 0.8
177 INT195007 Positive_regulation of Gene_expression of Aifm1 1 0.40 4.75 0.79
178 INT195016 Gene_expression of Aifm1 8 0.45 5.92 0.78
179 INT144429 Positive_regulation of Cdkn2a 7 0.58 4.05 0.78
180 INT148984 Positive_regulation of Localization of BAX 6 0.48 5.29 0.77
181 INT181667 Regulation of Regulation of Casp3 1 0.22 1.7 0.77
182 INT129115 Negative_regulation of Cdkn2a 16 0.50 17.03 0.76
183 INT129630 Regulation of Sod1 6 0.44 4.94 0.73
184 INT28561 Regulation of Gene_expression of SOD1 9 0.61 2.83 0.71
185 INT129490 Negative_regulation of Protein_catabolism of Casp3 4 0.22 3.91 0.71
186 INT133484 Negative_regulation of Localization of CYCS 4 0.42 2.77 0.7
187 INT169216 Negative_regulation of Positive_regulation of CYCS 1 0.42 0.82 0.7
188 INT351454 Regulation of Transcription of Casp3 1 0.02 0.51 0.67
189 INT53022 Gene_expression of CYCS 5 0.65 4.01 0.66
190 INT131976 Positive_regulation of Protein_catabolism of CASP3 4 0.49 3.76 0.64
191 INT47038 Gene_expression of SFRP1 14 0.67 9.6 0.63
192 INT195017 Negative_regulation of Positive_regulation of Aifm1 3 0.24 1.48 0.63
193 INT251026 Negative_regulation of Phosphorylation of CDKN2A 5 0.42 5.02 0.62
194 INT177886 Positive_regulation of Gene_expression of Cdkn2a 3 0.67 3.42 0.62
195 INT147598 Negative_regulation of Positive_regulation of CDKN2A 3 0.41 1.47 0.59
196 INT63533 Negative_regulation of Negative_regulation of Ppt1 1 0.29 0 0.59
197 INT242061 Positive_regulation of Negative_regulation of Casp3 3 0.09 1.7 0.58
198 INT184277 Regulation of Localization of HMGB1 1 0.37 1.15 0.58
199 INT181673 Negative_regulation of Transcription of Casp3 3 0.34 0.61 0.55
200 INT242011 Localization of Cdkn2a 4 0.73 2.49 0.54
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