GO:0006342

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Name chromatin silencing
Categary Process
Go Slim No
Go Link GO:0006342
Unique Molecular Interactions 36
Total Molecular Interactions 46
Total Single Events 545
Pain Genes Associated 9

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for chromatin silencing. They are ordered first by their pain relevance and then by number of times they were reported for chromatin silencing. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT227493 Binding of TCEA1 and SIRT2 1 0.01 1.55 1.93
2 INT144547 Binding of Mecp2 and Sin3a 1 0.40 0.87 0.76
3 INT135361 Prr14 Positive_regulation of Mecp2 1 0.24 0.15 0.64
4 INT135363 Mecp2 Positive_regulation of Mbd1 1 0.50 0.15 0.64
5 INT247265 Mecp2 Regulation of Fos 1 0.25 0.38 0.52
6 INT135360 Binding of Mecp2 and Aadac 1 0.03 0.19 0.51
7 INT227495 Regulation of Binding of TCEA1 and SIRT2 1 0.01 0.45 0.45
8 INT40208 Binding of Eef1a1 and Hils1 1 0.01 0.22 0.42
9 INT280479 Binding of Mecp2 and Sin3a 1 0.00 1.54 0.35
10 INT280475 Binding of Bdnf and Mecp2 1 0.11 0.92 0.22
11 INT280478 Mecp2 Negative_regulation of Gene_expression of Bdnf 1 0.13 0.94 0.22
12 INT280487 Negative_regulation of Binding of Mecp2 and Sin3a 1 0.00 0.77 0.18
13 INT318969 Mecp2 Regulation of Gene_expression of Bdnf 1 0.17 0.28 0.17
14 INT247266 Binding of Mecp2 and Fos 1 0.30 0.18 0.13
15 INT247267 Binding of Egr1 and Mecp2 1 0.12 0.18 0.13
16 INT247264 Mecp2 Positive_regulation of Gtf2i 1 0.02 0 0.08
17 INT248209 Camk2a Positive_regulation of Phosphorylation of Mecp2 1 0.52 0 0.08
18 INT332938 Suv39h1 Positive_regulation of Hist1h3f 1 0.06 0.12 0.03
19 INT204325 Binding of PPARGC1A and SIRT1 1 0.39 0.19 0
20 INT318218 SIRT1 Positive_regulation of Binding of FOXO3 1 0.44 0.51 0
21 INT318219 SIRT1 Regulation of TBK1 1 0.03 0.43 0
22 INT204326 SIRT1 Positive_regulation of PPARGC1A 1 0.51 0.19 0
23 INT318221 SIRT1 Positive_regulation of FOXO3 1 0.41 0.63 0
24 INT337637 SIRT1 Negative_regulation of TP53 1 0.23 1.49 0
25 INT304944 Positive_regulation of Binding of Tnp1 and Ca2 1 0.04 0.33 0
26 INT204321 NOS3 Regulation of SIRT1 1 0.23 0.1 0
27 INT225537 Binding of Paxip1 and Mll2 1 0.12 0 0
28 INT318216 SIRT1 Positive_regulation of Gene_expression of FOXO3 1 0.36 0.52 0
29 INT318217 SIRT1 Regulation of TP53 1 0.07 0.43 0
30 INT233117 Binding of SIRT2 and PAMR1 1 0.00 0 0
31 INT304945 Binding of Tnp1 and Ca2 1 0.03 0.97 0
32 INT233118 Binding of SIRT2 and AICDA 1 0.00 0.21 0
33 INT194925 Binding of CD22 and MLL2 1 0.08 0.18 0
34 INT204319 SIRT1 Regulation of Gene_expression of PPARGC1A 1 0.50 0.12 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for chromatin silencing. They are ordered first by their pain relevance and then by number of times they were reported in chromatin silencing. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT29988 Gene_expression of Mecp2 27 0.78 5.45 9.47
2 INT144539 Phosphorylation of Mecp2 3 0.82 6.18 6.2
3 INT135359 Positive_regulation of Mecp2 4 0.70 4.35 6.05
4 INT318967 Gene_expression of Mecp2 9 0.77 11.52 3.55
5 INT26696 Gene_expression of Hils1 4 0.21 1.18 2.38
6 INT13368 Binding of Hils1 5 0.23 0.46 2.14
7 INT144541 Negative_regulation of Gene_expression of Mecp2 3 0.42 1.43 1.9
8 INT180134 Gene_expression of SIRT2 70 0.11 6.95 1.84
9 INT247261 Negative_regulation of Mecp2 1 0.42 1.71 1.78
10 INT144538 Regulation of Phosphorylation of Mecp2 2 0.45 1.87 1.77
11 INT135355 Binding of Mecp2 4 0.37 0.83 1.72
12 INT144542 Positive_regulation of Phosphorylation of Mecp2 2 0.68 1.43 1.5
13 INT318963 Positive_regulation of Mecp2 5 0.50 1.78 1.49
14 INT247263 Regulation of Mecp2 4 0.60 1.31 1.32
15 INT41698 Localization of Hils1 3 0.16 0.54 1.29
16 INT18947 Negative_regulation of Hils1 3 0.04 1.11 1.27
17 INT280467 Negative_regulation of Mecp2 5 0.59 3.33 1.21
18 INT23415 Regulation of Hils1 2 0.27 0.29 1.18
19 INT180136 Localization of SIRT2 15 0.12 1.42 0.88
20 INT36494 Positive_regulation of Hils1 2 0.15 0.88 0.88
21 INT247262 Negative_regulation of Positive_regulation of Mecp2 1 0.42 0.85 0.8
22 INT180139 Protein_catabolism of SIRT2 11 0.14 1.1 0.72
23 INT318962 Negative_regulation of Gene_expression of Mecp2 2 0.43 0.5 0.7
24 INT183395 Localization of Mecp2 4 0.75 1.76 0.69
25 INT40069 Negative_regulation of Binding of Hils1 1 0.03 0.09 0.67
26 INT26695 Positive_regulation of Binding of Hils1 2 0.11 0.2 0.66
27 INT280463 Binding of Mecp2 3 0.37 4 0.63
28 INT247256 Negative_regulation of Phosphorylation of Mecp2 1 0.57 0.63 0.52
29 INT247259 Positive_regulation of Gene_expression of Mecp2 1 0.68 0.13 0.46
30 INT280468 Positive_regulation of Localization of Mecp2 3 0.50 1.76 0.45
31 INT318964 Negative_regulation of Localization of Mecp2 1 0.43 0.53 0.43
32 INT180142 Negative_regulation of SIRT2 10 0.07 0.19 0.41
33 INT180138 Negative_regulation of Gene_expression of SIRT2 2 0.07 0.19 0.41
34 INT280462 Positive_regulation of Phosphorylation of Mecp2 1 0.12 1.69 0.37
35 INT135356 Positive_regulation of Binding of Mecp2 1 0.50 0.1 0.36
36 INT204368 Gene_expression of SIRT1 17 0.76 4.48 0.3
37 INT92859 Positive_regulation of Positive_regulation of Hils1 1 0.03 0 0.3
38 INT338882 Regulation of Regulation of Mecp2 1 0.24 0.56 0.29
39 INT180144 Binding of SIRT2 57 0.06 1.29 0.27
40 INT248208 Phosphorylation of Mecp2 3 0.82 1.17 0.26
41 INT247260 Regulation of Gene_expression of Mecp2 1 0.60 0.06 0.21
42 INT41699 Positive_regulation of Localization of Hils1 1 0.11 0 0.2
43 INT175663 Positive_regulation of SIRT2 56 0.14 3.58 0.17
44 INT233124 Positive_regulation of Gene_expression of SIRT2 17 0.04 0.16 0.14
45 INT204365 Positive_regulation of Gene_expression of SIRT1 8 0.68 2.9 0.13
46 INT339991 Localization of SIRT1 1 0.34 0.3 0.06
47 INT318236 Negative_regulation of Gene_expression of SIRT1 1 0.42 0.59 0.05
48 INT332918 Localization of Suv39h1 1 0.73 0.11 0.03
49 INT204367 Positive_regulation of SIRT1 13 0.68 4.17 0
50 INT204349 Regulation of SIRT1 8 0.61 1.99 0
51 INT233125 Positive_regulation of Positive_regulation of SIRT2 4 0.04 0 0
52 INT204353 Transcription of SIRT1 3 0.68 0.67 0
53 INT180140 Regulation of SIRT2 3 0.04 0 0
54 INT233126 Regulation of Gene_expression of SIRT2 2 0.03 0 0
55 INT180146 Positive_regulation of Binding of SIRT2 2 0.08 0 0
56 INT233120 Regulation of Binding of SIRT2 1 0.03 0 0
57 INT304943 Negative_regulation of Tnp1 1 0.04 0.42 0
58 INT320943 Negative_regulation of Phosphorylation of Mecp2 1 0.43 0.33 0
59 INT204361 Negative_regulation of SIRT1 1 0.42 0.18 0
60 INT304942 Negative_regulation of Positive_regulation of Tnp1 1 0.04 0.42 0
61 INT194935 Binding of MLL2 1 0.10 0.17 0
62 INT204371 Positive_regulation of Transcription of SIRT1 1 0.49 0.13 0
63 INT320939 Transcription of Mecp2 1 0.69 0.2 0
64 INT328132 Regulation of Mecp2 1 0.40 1 0
65 INT301188 Regulation of Positive_regulation of SIRT2 1 0.03 1.05 0
66 INT318239 Regulation of Transcription of SIRT1 1 0.26 0.45 0
67 INT320952 Regulation of Gene_expression of Mecp2 1 0.45 0.87 0
68 INT320949 Negative_regulation of Binding of Mecp2 1 0.43 0.21 0
69 INT180143 Phosphorylation of SIRT2 1 0.13 0 0
70 INT225430 Gene_expression of Mll2 1 0.33 0 0
71 INT350520 Phosphorylation of SIRT1 1 0.25 0.72 0
72 INT204356 Regulation of Gene_expression of SIRT1 1 0.61 0.29 0
73 INT276275 Positive_regulation of Localization of SIRT2 1 0.04 0 0
74 INT276271 Transcription of SIRT2 1 0.05 0 0
75 INT304941 Positive_regulation of Tnp1 1 0.07 0.73 0
76 INT276273 Positive_regulation of Protein_catabolism of SIRT2 1 0.04 0.06 0
77 INT204331 Binding of SIRT1 1 0.47 0.39 0
78 INT233121 Negative_regulation of Positive_regulation of SIRT2 1 0.03 0.26 0
79 INT320950 Positive_regulation of Gene_expression of Mecp2 1 0.50 1.24 0
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