GO:0006346

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Name methylation-dependent chromatin silencing
Categary Process
Go Slim No
Go Link GO:0006346
Unique Molecular Interactions 34
Total Molecular Interactions 42
Total Single Events 245
Pain Genes Associated 7

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for methylation-dependent chromatin silencing. They are ordered first by their pain relevance and then by number of times they were reported for methylation-dependent chromatin silencing. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT73116 TYMS Negative_regulation of DNMT3B 1 0.24 0 1.6
2 INT73115 TYMS Negative_regulation of Positive_regulation of DNMT3B 1 0.24 0 1.6
3 INT285718 Binding of DNMT3B and Lbp 1 0.08 0.33 0.33
4 INT228611 Binding of DNMT3B and LEP 1 0.04 0 0.25
5 INT228610 Binding of DNMT3B and ASPRV1 1 0.02 0 0.05
6 INT241268 DNMT3B Positive_regulation of Gene_expression of DNMT1 1 0.19 0.67 0
7 INT183412 Dnmt3a Positive_regulation of Tbx15 1 0.05 0.27 0
8 INT204325 Binding of PPARGC1A and SIRT1 1 0.39 0.19 0
9 INT273949 Binding of Crem and Smarca4 1 0.01 0 0
10 INT241266 DNMT3B Positive_regulation of Gene_expression of GOPC 1 0.05 0.68 0
11 INT318218 SIRT1 Positive_regulation of Binding of FOXO3 1 0.44 0.51 0
12 INT183413 Dnmt3a Positive_regulation of Gene_expression of Dnmt3b 1 0.10 0.28 0
13 INT241264 DNMT1 Positive_regulation of Gene_expression of DNMT3B 1 0.19 0.67 0
14 INT241257 DNMT3B Positive_regulation of OPCML 1 0.35 0.68 0
15 INT318219 SIRT1 Regulation of TBK1 1 0.03 0.43 0
16 INT241259 DNMT3B Positive_regulation of GOPC 1 0.05 0.68 0
17 INT183415 Dnmt3b Positive_regulation of Gene_expression of Dnmt3a 1 0.10 0.28 0
18 INT351982 Smarca4 Positive_regulation of Stk11 1 0.05 0.58 0
19 INT204326 SIRT1 Positive_regulation of PPARGC1A 1 0.51 0.19 0
20 INT318221 SIRT1 Positive_regulation of FOXO3 1 0.41 0.63 0
21 INT337637 SIRT1 Negative_regulation of TP53 1 0.23 1.49 0
22 INT253331 Binding of DNMT3B and SP140 1 0.04 0.17 0
23 INT204321 NOS3 Regulation of SIRT1 1 0.23 0.1 0
24 INT183410 Dnmt3b Positive_regulation of Tbx15 1 0.05 0.27 0
25 INT191135 Binding of DNMT3A and DNMT3B 1 0.09 0 0
26 INT318216 SIRT1 Positive_regulation of Gene_expression of FOXO3 1 0.36 0.52 0
27 INT318217 SIRT1 Regulation of TP53 1 0.07 0.43 0
28 INT204319 SIRT1 Regulation of Gene_expression of PPARGC1A 1 0.50 0.12 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for methylation-dependent chromatin silencing. They are ordered first by their pain relevance and then by number of times they were reported in methylation-dependent chromatin silencing. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT73117 Positive_regulation of DNMT3B 20 0.47 10.31 5.31
2 INT136106 Gene_expression of DNMT3B 30 0.58 8.43 3.7
3 INT121531 Negative_regulation of DNMT3B 13 0.36 3.46 3.05
4 INT133038 Binding of DNMT3B 26 0.40 5.97 2.83
5 INT157500 Localization of DNMT3B 12 0.73 2.21 1.38
6 INT46336 Regulation of DNMT3B 12 0.53 4.91 1.25
7 INT322088 Regulation of Regulation of DNMT3B 1 0.03 2.74 1.12
8 INT285716 Negative_regulation of Gene_expression of DNMT3B 1 0.21 0.96 0.96
9 INT241287 Positive_regulation of Gene_expression of DNMT3B 3 0.40 1.21 0.57
10 INT306690 Negative_regulation of Dnmt3b 1 0.00 0.56 0.39
11 INT204368 Gene_expression of SIRT1 17 0.76 4.48 0.3
12 INT300944 Regulation of DNMT3A 1 0.21 0.91 0.24
13 INT291670 Negative_regulation of Dnmt3a 1 0.31 0.7 0.14
14 INT204365 Positive_regulation of Gene_expression of SIRT1 8 0.68 2.9 0.13
15 INT191163 Transcription of DNMT3B 4 0.50 0.46 0.13
16 INT292609 Negative_regulation of Positive_regulation of DNMT3B 1 0.22 1.3 0.07
17 INT339991 Localization of SIRT1 1 0.34 0.3 0.06
18 INT318236 Negative_regulation of Gene_expression of SIRT1 1 0.42 0.59 0.05
19 INT183393 Gene_expression of Dnmt3a 3 0.43 1.08 0.04
20 INT291678 Regulation of Dnmt3a 1 0.28 0.48 0.04
21 INT260908 Positive_regulation of Smarca4 2 0.21 0.53 0.03
22 INT204367 Positive_regulation of SIRT1 13 0.68 4.17 0
23 INT204349 Regulation of SIRT1 8 0.61 1.99 0
24 INT204353 Transcription of SIRT1 3 0.68 0.67 0
25 INT284943 Gene_expression of DNMT3A 2 0.39 1.46 0
26 INT284947 Positive_regulation of Gene_expression of DNMT3A 2 0.25 1.29 0
27 INT191158 Transcription of DNMT3A 1 0.32 0.06 0
28 INT191157 Negative_regulation of Transcription of DNMT3B 1 0.19 0.06 0
29 INT191156 Binding of DNMT3A 1 0.16 0 0
30 INT204361 Negative_regulation of SIRT1 1 0.42 0.18 0
31 INT191160 Localization of DNMT3A 1 0.35 0 0
32 INT185991 Regulation of Gene_expression of DNMT3B 1 0.37 0 0
33 INT204371 Positive_regulation of Transcription of SIRT1 1 0.49 0.13 0
34 INT191152 Negative_regulation of Transcription of DNMT3A 1 0.20 0.06 0
35 INT318239 Regulation of Transcription of SIRT1 1 0.26 0.45 0
36 INT350520 Phosphorylation of SIRT1 1 0.25 0.72 0
37 INT204356 Regulation of Gene_expression of SIRT1 1 0.61 0.29 0
38 INT183396 Positive_regulation of Gene_expression of Dnmt3a 1 0.20 0.59 0
39 INT260913 Negative_regulation of Smarca4 1 0.18 0.29 0
40 INT273916 Binding of Smarca4 1 0.01 0 0
41 INT183391 Positive_regulation of Gene_expression of Dnmt3b 1 0.20 0.59 0
42 INT183398 Gene_expression of Dnmt3b 1 0.27 0.59 0
43 INT338263 Regulation of Gene_expression of DNMT3A 1 0.31 0.18 0
44 INT204331 Binding of SIRT1 1 0.47 0.39 0
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