GO:0006367

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Name transcription initiation from RNA polymerase II promoter
Categary Process
Go Slim No
Go Link GO:0006367
Unique Molecular Interactions 101
Total Molecular Interactions 131
Total Single Events 702
Pain Genes Associated 18

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for transcription initiation from RNA polymerase II promoter. They are ordered first by their pain relevance and then by number of times they were reported for transcription initiation from RNA polymerase II promoter. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT350342 Tbp Positive_regulation of Ltp 1 0.25 0.48 0.64
2 INT122823 ERCC2 Regulation of Negative_regulation of OPRM1 1 0.23 0.17 0.63
3 INT153657 PRKCA Negative_regulation of MED23 1 0.01 0.22 0.46
4 INT306828 Binding of E2F2 and E2F3 1 0.20 0.15 0.46
5 INT306824 Binding of E2F1 and E2F2 1 0.15 0.15 0.46
6 INT334180 Tdo2 Negative_regulation of Tbpl1 1 0.10 0.16 0.45
7 INT306830 E2F2 Regulation of C1orf61 1 0.02 0.48 0.36
8 INT306822 Binding of E2F2 and GOPC 1 0.05 0.53 0.35
9 INT262307 CAPNS1 Regulation of TAF9 1 0.04 1.23 0.33
10 INT142947 Binding of ERCC2 and OPRM1 1 0.05 0.3 0.32
11 INT213813 Binding of Tcf4 and Tfeb 1 0.14 0.81 0.24
12 INT186191 Binding of SCARB1 and TBP 1 0.03 2.57 0.24
13 INT213805 Binding of Tcf12 and Tcf4 1 0.00 0.79 0.23
14 INT100514 Binding of Oprl1 and Tbpl1 1 0.02 0 0.22
15 INT61976 TBP Negative_regulation of Tnf 1 0.24 1.17 0.17
16 INT190634 Binding of Lmo2 and Maz 1 0.14 0.59 0.16
17 INT156833 Binding of MED1 and TRPV6 1 0.32 0 0.15
18 INT156837 Binding of CYP24A1 and MED1 1 0.47 0 0.15
19 INT123194 Bmp6 Positive_regulation of TAF9 1 0.18 0.61 0.14
20 INT61965 TBP Negative_regulation of TNF 1 0.07 1.01 0.14
21 INT123193 Bmp6 Positive_regulation of Negative_regulation of TAF9 1 0.18 0.61 0.14
22 INT103557 Binding of ERCC2 and TP53 1 0.40 1 0.13
23 INT302156 AKT1 Positive_regulation of E2F2 1 0.02 0.88 0.13
24 INT241252 Binding of Pkd1 and Tbpl1 1 0.02 0.79 0.1
25 INT238392 RB1 Regulation of E2F2 1 0.01 0.36 0.08
26 INT238397 EID1 Regulation of E2F2 1 0.00 0.36 0.08
27 INT350345 Tbp Positive_regulation of Positive_regulation of Grin1 1 0.18 0 0.07
28 INT225490 Med1 Positive_regulation of Ppara 1 0.12 0.26 0.06
29 INT284449 Il11 Positive_regulation of TCF4 1 0.00 0.42 0.05
30 INT186192 Binding of SCARB2 and TBP 1 0.02 0.58 0.05
31 INT261393 Binding of Nsdhl and Med1 1 0.02 1 0.04
32 INT334278 Binding of Tbp and Tk1 1 0.13 0.12 0.03
33 INT334277 Binding of Mki67 and Tbp 1 0.12 0.12 0.03
34 INT236720 Binding of Ctnnd2 and Tcf4 3 0.24 2.8 0
35 INT238393 Binding of E2F2 and RB1 3 0.04 0.24 0
36 INT225585 Regulation of Binding of Med1 and Tpr 1 0.00 0.07 0
37 INT219409 CCNF Regulation of E2F2 1 0.22 0.11 0
38 INT306827 Binding of E2F2 and NOLC1 1 0.07 0.05 0
39 INT204325 Binding of PPARGC1A and SIRT1 1 0.39 0.19 0
40 INT182402 E2F2 Regulation of CCNB1 1 0.00 0.09 0
41 INT217779 POLR2B Regulation of Gene_expression of RASGRP1 1 0.01 0.2 0
42 INT177262 Binding of MED1 and SV2A 1 0.23 0 0
43 INT225630 MED23 Positive_regulation of Localization of D0Nrs1 1 0.03 0.17 0
44 INT225645 Binding of TAF1 and Acp5 1 0.01 0 0
45 INT217785 POLR2B Regulation of Gene_expression of MAP3K3 1 0.06 0.2 0
46 INT326898 Positive_regulation of Tcf4 Regulation of PLD2 1 0.26 0.33 0
47 INT225641 Binding of MED23 and Acp5 1 0.39 0.14 0
48 INT306825 Positive_regulation of Binding of E2F2 and RB1 1 0.04 0.05 0
49 INT215345 Positive_regulation of Binding of Srebf1 and Tbp 1 0.05 0.16 0
50 INT326893 Binding of Tcf4 and Wnt3a 1 0.13 0 0
51 INT204322 Binding of ADIPOQ and Positive_regulation of Gene_expression of PPARGC1A 1 0.30 0.07 0
52 INT337408 Binding of TCF4 and KLF4 1 0.09 0 0
53 INT326899 Tcf4 Positive_regulation of PLD2 1 0.28 0.49 0
54 INT182399 E2F2 Regulation of CDK1 1 0.00 0.09 0
55 INT330696 Phosphorylation of RB1 Positive_regulation of Gene_expression of E2F2 1 0.01 1 0
56 INT215343 Binding of Srebf1 and Tbp 1 0.04 0.16 0
57 INT326895 Binding of PLD2 and Tcf4 1 0.27 0.39 0
58 INT326900 Tcf4 Regulation of PLD2 1 0.15 0.33 0
59 INT204326 SIRT1 Positive_regulation of PPARGC1A 1 0.51 0.19 0
60 INT225481 Binding of Med1 and Acp5 1 0.16 0 0
61 INT252900 PTTG1 Regulation of Gene_expression of TAF9 1 0.20 0.84 0
62 INT177286 Binding of CXADR and MED1 1 0.27 0 0
63 INT149429 ERCC2 Negative_regulation of Localization of IL8 1 0.05 0.38 0
64 INT225633 Binding of STL and MED23 1 0.02 0 0
65 INT250038 Binding of Alb and Tbpl1 1 0.03 0.28 0
66 INT219427 CCNE2 Regulation of E2F2 1 0.11 0.11 0
67 INT219408 CCNA2 Regulation of E2F2 1 0.11 0.11 0
68 INT306829 Binding of E2F2 and RBL1 1 0.09 0.06 0
69 INT227840 Binding of ERCC2 and ERCC6 1 0.11 0.66 0
70 INT297563 Binding of HSD11B1 and TBPL1 1 0.01 0.41 0
71 INT326892 Tcf4 Positive_regulation of Pld1 1 0.28 0.05 0
72 INT149431 ERCC2 Negative_regulation of Localization of Il6 1 0.14 0.2 0
73 INT227831 Binding of ERCC2 and PGBD3 1 0.07 0.23 0
74 INT182400 E2F2 Regulation of CDC25C 1 0.00 0.09 0
75 INT352860 Positive_regulation of POLR2B Positive_regulation of Positive_regulation of IKBKAP 1 0.03 0.74 0
76 INT326902 Binding of HNF4A and Tcf4 1 0.02 0.35 0
77 INT215342 Binding of Cebpg and Tbp 1 0.00 0.55 0
78 INT225541 Binding of Med1 and Tpr 1 0.00 0.07 0
79 INT252893 PTTG1 Positive_regulation of Gene_expression of TAF9 1 0.21 0.9 0
80 INT225634 Binding of TARBP2 and MED23 1 0.04 0.15 0
81 INT287874 Binding of TCF4 and TP53 1 0.02 0.54 0
82 INT225628 MED23 Positive_regulation of D0Nrs1 1 0.03 0.16 0
83 INT177280 Binding of MED1 and FAUP1 1 0.01 0 0
84 INT225625 Binding of MED23 and Ncoa6 1 0.40 0.41 0
85 INT149432 ERCC2 Regulation of Localization of Il6 1 0.15 1.06 0
86 INT292149 Binding of GTF2B and SP1 1 0.03 0.4 0
87 INT149428 ERCC2 Regulation of Localization of IL8 1 0.05 0.53 0
88 INT219419 CDK2 Regulation of E2F2 1 0.23 0.11 0
89 INT204319 SIRT1 Regulation of Gene_expression of PPARGC1A 1 0.50 0.12 0
90 INT337406 Binding of TCF4 and TNIK 1 0.18 0 0
91 INT182405 E2F2 Regulation of CCNE2 1 0.00 0.09 0
92 INT326897 Tcf4 Positive_regulation of Gene_expression of PLD2 1 0.26 0.41 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for transcription initiation from RNA polymerase II promoter. They are ordered first by their pain relevance and then by number of times they were reported in transcription initiation from RNA polymerase II promoter. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT103899 Gene_expression of ERCC2 14 0.65 7.85 5.49
2 INT101168 Gene_expression of Tbpl1 23 0.75 10.88 5.38
3 INT174189 Gene_expression of E2F2 19 0.49 12.58 4.71
4 INT252968 Positive_regulation of TAF9 11 0.45 5.28 3.68
5 INT33661 Regulation of Tbpl1 7 0.44 5.36 3.26
6 INT252999 Gene_expression of TAF9 12 0.75 12.65 2.92
7 INT306835 Regulation of E2F2 1 0.39 2.52 2.62
8 INT175703 Negative_regulation of E2F2 6 0.38 3.47 2.44
9 INT9119 Negative_regulation of TAF9 4 0.42 5.21 2.16
10 INT262317 Binding of TAF9 7 0.31 9.67 2.15
11 INT283044 Regulation of Gene_expression of Tbpl1 3 0.15 3.87 2
12 INT103900 Positive_regulation of ERCC2 7 0.58 3.47 1.78
13 INT148237 Positive_regulation of Tbpl1 4 0.49 2.05 1.59
14 INT182427 Binding of E2F2 7 0.23 2.78 1.49
15 INT306857 Binding of E2F3 1 0.21 1.22 1.24
16 INT55315 Gene_expression of Tbp 32 0.74 14.6 1.17
17 INT142950 Protein_catabolism of ERCC2 2 0.25 1.45 1.14
18 INT260285 Gene_expression of E2F3 6 0.54 2.51 1.13
19 INT238440 Negative_regulation of Binding of E2F2 3 0.27 1.09 1.07
20 INT238433 Negative_regulation of Gene_expression of E2F2 2 0.27 1.01 1.07
21 INT306846 Negative_regulation of Binding of E2F3 1 0.24 0.65 0.94
22 INT306891 Negative_regulation of E2F3 1 0.25 0.65 0.94
23 INT52454 Localization of Tbp 7 0.76 2.53 0.91
24 INT52455 Negative_regulation of Tbp 3 0.25 1.75 0.91
25 INT7822 Binding of Tbpl1 2 0.47 0.11 0.89
26 INT137572 Gene_expression of Maz 3 0.66 10.9 0.85
27 INT306862 Regulation of Gene_expression of E2F2 1 0.17 0.19 0.85
28 INT283043 Positive_regulation of Gene_expression of Tbpl1 6 0.17 4.67 0.83
29 INT306834 Positive_regulation of Gene_expression of E2F3 2 0.29 1 0.82
30 INT306867 Positive_regulation of Gene_expression of E2F2 1 0.31 0.59 0.82
31 INT61971 Gene_expression of TBP 9 0.65 5.14 0.8
32 INT71876 Regulation of Tbp 4 0.43 1.03 0.8
33 INT7830 Regulation of Binding of Tbpl1 1 0.26 0 0.79
34 INT127329 Negative_regulation of Tbpl1 2 0.41 0.51 0.6
35 INT323004 Transcription of TAF9 1 0.05 0.79 0.54
36 INT61972 Negative_regulation of TBP 5 0.32 3.56 0.53
37 INT304623 Regulation of Regulation of Tbpl1 1 0.06 0.76 0.53
38 INT134070 Binding of ERCC2 3 0.27 0.76 0.51
39 INT250027 Localization of Tbpl1 1 0.43 0.61 0.48
40 INT250028 Regulation of Localization of Tbpl1 1 0.17 0.61 0.48
41 INT130141 Phosphorylation of POLR2B 1 0.29 0.57 0.47
42 INT175702 Positive_regulation of E2F2 2 0.43 0.46 0.46
43 INT283039 Negative_regulation of Transcription of Tbpl1 1 0.10 1.19 0.46
44 INT283038 Transcription of Tbpl1 1 0.12 1.19 0.46
45 INT153673 Negative_regulation of MED23 1 0.02 0.27 0.42
46 INT137574 Positive_regulation of Gene_expression of Maz 2 0.42 4.67 0.41
47 INT61975 Positive_regulation of TBP 5 0.28 4.01 0.4
48 INT103901 Regulation of ERCC2 1 0.23 0.51 0.4
49 INT350319 Negative_regulation of Localization of Tbp 1 0.20 0 0.4
50 INT322997 Localization of TAF9 1 0.05 1.2 0.4
51 INT145045 Gene_expression of Med1 29 0.65 5.37 0.39
52 INT233917 Gene_expression of MED1 2 0.20 0.17 0.38
53 INT137573 Binding of Maz 2 0.31 3.78 0.38
54 INT234421 Binding of TCF4 13 0.18 2.3 0.37
55 INT252969 Positive_regulation of Gene_expression of TAF9 5 0.67 5.22 0.32
56 INT238429 Transcription of E2F2 3 0.45 0.55 0.31
57 INT106734 Phosphorylation of MED1 4 0.74 1.65 0.28
58 INT98598 Negative_regulation of Positive_regulation of TCF4 1 0.22 0.57 0.28
59 INT98596 Positive_regulation of TCF4 3 0.26 1.13 0.27
60 INT215331 Positive_regulation of Tbp 8 0.66 1.73 0.26
61 INT114369 Positive_regulation of Tcf4 6 0.40 2.7 0.25
62 INT185282 Localization of E2F2 3 0.47 1.92 0.25
63 INT199276 Binding of Tbp 12 0.46 2.67 0.24
64 INT306879 Negative_regulation of Transcription of E2F2 1 0.37 0.07 0.24
65 INT190599 Positive_regulation of Maz 1 0.20 1.05 0.24
66 INT239796 Binding of TAF1 1 0.01 0.33 0.23
67 INT354941 Negative_regulation of Gene_expression of Tbp 1 0.17 0 0.21
68 INT114372 Negative_regulation of Tcf4 2 0.25 0.7 0.2
69 INT204348 Gene_expression of PPARGC1A 10 0.75 2.73 0.19
70 INT197429 Gene_expression of TCF4 6 0.33 3.8 0.18
71 INT61973 Positive_regulation of Gene_expression of TBP 2 0.49 1.5 0.18
72 INT61974 Positive_regulation of Negative_regulation of TBP 1 0.28 1.2 0.18
73 INT190558 Negative_regulation of Localization of Maz 1 0.21 0.61 0.17
74 INT190574 Localization of Maz 1 0.37 0.6 0.17
75 INT114370 Negative_regulation of Positive_regulation of Tcf4 1 0.10 0.63 0.17
76 INT210249 Gene_expression of Tcf4 14 0.66 4.32 0.16
77 INT106730 Regulation of Phosphorylation of MED1 2 0.24 0.7 0.16
78 INT106731 Negative_regulation of Phosphorylation of MED1 1 0.02 0.96 0.12
79 INT114901 Binding of TBP 6 0.17 2.45 0.11
80 INT236704 Binding of Tcf4 3 0.28 3.3 0.1
81 INT324246 Regulation of GTF2B 1 0.02 0.2 0.1
82 INT326846 Negative_regulation of Binding of Tcf4 1 0.25 0.26 0.1
83 INT234413 Transcription of TCF4 3 0.34 1 0.09
84 INT287943 Negative_regulation of Transcription of TCF4 1 0.15 0 0.09
85 INT287918 Negative_regulation of Binding of TCF4 1 0.15 0 0.09
86 INT252991 Regulation of TAF9 2 0.44 3.54 0.08
87 INT204332 Positive_regulation of PPARGC1A 7 0.67 1.42 0.07
88 INT156864 Positive_regulation of Phosphorylation of MED1 1 0.45 0 0.07
89 INT200136 Negative_regulation of ERCC2 1 0.37 1.91 0.07
90 INT257607 Regulation of Maz 1 0.27 2.07 0.06
91 INT178749 Regulation of TBPL1 1 0.01 0 0.04
92 INT309258 Localization of TBP 2 0.27 1.78 0.03
93 INT175888 Gene_expression of POLR2B 2 0.04 0.32 0.03
94 INT257610 Regulation of Gene_expression of Maz 1 0.31 0.19 0.03
95 INT268681 Binding of GTF2B 1 0.21 1.16 0.03
96 INT291906 Positive_regulation of Negative_regulation of ERCC2 1 0.40 0 0.03
97 INT285237 Localization of TBPL1 8 0.15 2.53 0
98 INT210244 Positive_regulation of Gene_expression of Tcf4 4 0.59 1.49 0
99 INT287187 Regulation of TBP 3 0.13 2.42 0
100 INT210250 Negative_regulation of Gene_expression of Tcf4 3 0.36 0.26 0
101 INT260292 Positive_regulation of E2F3 3 0.55 1.33 0
102 INT204372 Transcription of PPARGC1A 3 0.67 0.28 0
103 INT185289 Phosphorylation of E2F2 3 0.11 1.39 0
104 INT337481 Positive_regulation of Binding of TCF4 3 0.25 0.47 0
105 INT307189 Localization of Med1 3 0.53 0.32 0
106 INT298408 Transcription of POLR2B 3 0.12 2.78 0
107 INT175893 Regulation of POLR2B 2 0.08 1.34 0
108 INT210257 Regulation of Tcf4 2 0.27 0.59 0
109 INT225400 Positive_regulation of Gene_expression of Med1 2 0.35 0.82 0
110 INT236690 Transcription of Tcf4 2 0.41 0.98 0
111 INT204346 Positive_regulation of Transcription of PPARGC1A 2 0.49 0.28 0
112 INT225358 Negative_regulation of Gene_expression of Med1 2 0.30 1.16 0
113 INT297578 Regulation of Gene_expression of TBPL1 1 0.09 0.45 0
114 INT177336 Positive_regulation of Binding of MED1 1 0.24 0 0
115 INT337480 Phosphorylation of TCF4 1 0.40 0.06 0
116 INT211829 Protein_catabolism of TBP 1 0.17 0.09 0
117 INT175901 Negative_regulation of POLR2B 1 0.00 0.34 0
118 INT215318 Regulation of Localization of Tbp 1 0.43 0.58 0
119 INT307197 Negative_regulation of Med1 1 0.30 0.7 0
120 INT185288 Negative_regulation of Localization of E2F2 1 0.07 1.02 0
121 INT298404 Regulation of Transcription of POLR2B 1 0.05 1.02 0
122 INT215337 Positive_regulation of Gene_expression of Tbp 1 0.48 0.45 0
123 INT326839 Positive_regulation of Positive_regulation of Tcf4 1 0.29 0.4 0
124 INT292838 Gene_expression of TAF1 1 0.04 0.48 0
125 INT322322 Transcription of TBP 1 0.22 0.61 0
126 INT307188 Transcription of Med1 1 0.48 0.7 0
127 INT326841 Negative_regulation of Transcription of Tcf4 1 0.25 0 0
128 INT204350 Negative_regulation of Transcription of PPARGC1A 1 0.41 0.1 0
129 INT257612 Transcription of Maz 1 0.48 1.7 0
130 INT297579 Gene_expression of TBPL1 1 0.16 0.45 0
131 INT204333 Regulation of PPARGC1A 1 0.26 0.34 0
132 INT308399 Gene_expression of MED23 1 0.58 1.26 0
133 INT225389 Regulation of Binding of Med1 1 0.17 0.07 0
134 INT177320 Binding of MED1 1 0.25 0 0
135 INT225457 Binding of Med1 1 0.35 0.28 0
136 INT352861 Positive_regulation of Transcription of POLR2B 1 0.04 0.73 0
137 INT204357 Positive_regulation of Positive_regulation of PPARGC1A 1 0.49 0.07 0
138 INT287939 Positive_regulation of Negative_regulation of TCF4 1 0.17 0.52 0
139 INT287916 Negative_regulation of TCF4 1 0.20 0.52 0
140 INT204347 Positive_regulation of Negative_regulation of PPARGC1A 1 0.49 0 0
141 INT204369 Negative_regulation of Positive_regulation of PPARGC1A 1 0.41 0.07 0
142 INT337485 Positive_regulation of Transcription of TCF4 1 0.25 0.26 0
143 INT210253 Regulation of Gene_expression of Tcf4 1 0.23 0.09 0
144 INT346970 Binding of POLR2B 1 0.03 0.36 0
145 INT257609 Positive_regulation of Transcription of Maz 1 0.35 0.74 0
146 INT308403 Negative_regulation of Gene_expression of MED23 1 0.42 1.31 0
147 INT352872 Positive_regulation of POLR2B 1 0.05 0.72 0
148 INT149430 Localization of ERCC2 1 0.43 0.76 0
149 INT215339 Positive_regulation of Positive_regulation of Tbp 1 0.48 0.42 0
150 INT287952 Positive_regulation of Gene_expression of TCF4 1 0.17 0.69 0
151 INT341851 Positive_regulation of MED1 1 0.01 0.5 0
152 INT204366 Positive_regulation of Gene_expression of PPARGC1A 1 0.67 1.44 0
153 INT334482 Regulation of Gene_expression of Med1 1 0.17 0.1 0
154 INT204337 Regulation of Gene_expression of PPARGC1A 1 0.44 0.48 0
155 INT204339 Binding of PPARGC1A 1 0.35 0.19 0
156 INT257608 Negative_regulation of Gene_expression of Maz 1 0.30 0.09 0
157 INT204329 Positive_regulation of Regulation of PPARGC1A 1 0.45 0.07 0
158 INT252984 Regulation of Gene_expression of TAF9 1 0.26 0.99 0
159 INT225468 Binding of MED23 1 0.47 0 0
160 INT236696 Positive_regulation of Transcription of Tcf4 1 0.08 0.98 0
161 INT204341 Negative_regulation of Gene_expression of PPARGC1A 1 0.41 0 0
162 INT326840 Positive_regulation of Binding of Tcf4 1 0.29 0.07 0
163 INT204351 Negative_regulation of PPARGC1A 1 0.42 0.25 0
164 INT334481 Negative_regulation of Localization of Med1 1 0.16 0.09 0
165 INT215323 Positive_regulation of Binding of Tbp 1 0.48 0.91 0
166 INT308401 Positive_regulation of MED23 1 0.45 1.27 0
167 INT215336 Positive_regulation of Localization of Tbp 1 0.48 0.57 0
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